Chapters authored
A Short Review of Hematopoietic Transplantation for AL Amyloidosis
AL amyloidosis is an uncommon disease with variable clinical presentations; as such, it is often initially unrecognized and diagnosis is therefore frequently delayed. As a result of diagnosis at a point in their disease when patients often have significant end-organ damage, aggressive therapy with major toxicities can be extremely challenging. Nonetheless, clinical data have been accumulating over the past several decades that have demonstrated that patients who were taken to high-dose therapy—typically using single-agent L-phenylalanine mustard—with autologous hematopoietic rescue, have a dramatically improved overall survival than otherwise. In this chapter, the critical clinical data that demonstrate this, and the risk-adjusted approach to optimize the outcome for patients, are reviewed.
Part of the book: Amyloidosis