Chapters authored
The Anticancer Profile of Benzimidazolium Salts and Their Metal Complexes
Cancer is the most lethal ailment throughout the world in the present era. The development of new anticancer remedies with minor unhealthful effects and an alternate mechanism is crucial. Benzimidazole is a distinguished heterocyclic compound and is now recognized as the privileged scaffold for new drug discovery. This chapter deals with the anticancer capability of benzimidazolium salts and their metal complexes. The benzimidazolium derivatives have been prepared by the introduction of aliphatic and aromatic groups at two nitrogen atoms of the benzimidazole ring. Other modifications include hybridization with other pharmacophores and the preparation of metal complexes. The potent derivatives presented in this review can serve as novel drug candidates against cancer.
Part of the book: Benzimidazole
Drug Metabolism: Phase I and Phase II Metabolic Pathways
Drug metabolism comprises the metabolism of endogenous and exogenous substances. During metabolism most drugs lose the pharmacological activity and are excreted from the body. Drug metabolic reactions are divided into two classes i.e. phase I and phase II metabolic reactions. The characterisation of drug metabolising enzyme is necessary in order to determine the toxic metabolites of drugs. The understanding of drug metabolism is essential for new drug design and development. The evaluation of pharmacokinetic properties is necessary to see whether they can be useful drug candidates. In this chapter we have discussed drug metabolic reaction and drug metabolising enzymes with the help of examples of drug molecules.
Part of the book: Drug Metabolism and Pharmacokinetics