\r\n\tApplied and basic studies - Field studies and lab assays of fungicides can be discussed. We also look for examples of application methods, which may include timing of application, tools for application, fungicide compatibility, phytotoxicity, etc. Field trials have to have at least two years of data;
\r\n\tAdaptation of Integrated Plant Disease Management - How the IPM practice has been adapted in the field. Application of disease risk models, or use of fungicide application aids, which can be hardware or software. The introduction of a new tool for growers can also be included;
\r\n\tNovel fungicides - In addition to the traditional chemical approach, alternative materials (enzymes, oils, extracts, etc.), biological control agents, or plant defense activators can be discussed;
\r\n\tAdaptation of new technologies - Examples will be the use of unmanned vehicles, sensor technologies, advanced sprayers, or disease forecast systems for precision agriculture;
\r\n\tFungicide resistance - Unfortunately, we cannot ignore the fact that fungicide-resistant strains are widespread. Documentation of fungicide-resistant strains, the introduction of new technologies and methods can be discussed.
The importance of DVT prophylaxis is well understood from the high incidence of DVT in patients undergoing total knee arthroplasty (TKA). Studies have shown that without any mechanical or pharmacologic prophylaxis, asymptomatic DVT develops in 40–60% of the patients undergoing total hip and knee arthroplasties. Hence, there is a general consensus that these patients require regular prophylaxis even beyond discharge [1]. Venous thrombosis, including deep-vein thrombosis, occurs at an annual incidence of about 1 per 1000 adults and is higher in men than that in women in older age. DVT incidence varies according to the race and ethnicity. Asians have a very low incidence of deep-vein thrombosis due to the preferred vegetarian diet, low prevalence of obesity, hyperlipidemia, and Factor V Leiden mutation. Several meta-analysis studies have shown similar results of low DVT incidence in Asians [2]. Operating surgeon has to minimize the risk of occurrence of this complication and its associated morbidity and mortality. Surgeon’s choice of VTE prophylaxis should be based on a balance between safety and efficacy of a particular anticoagulant, with risk stratification of VTE or bleeding. Virchow’s triad of events—stasis, vascular endothelial injury, and hypercoagulability, increases the risk of deep-vein thrombosis (DVT). Patients who fulfill two of the three criteria are considered to be high-risk group. Most of the patients undergoing TKA are considered to be at high risk for DVT for the high incidence of endothelial injury during the surgery and the relative stasis during the postoperative period. Well’s criteria help us to stratify risk in these patients (Figure 1).
Well’s criteria for DVT risk stratification.
Patients without prior clinical suspicion also can develop DVT and fatal pulmonary embolism. Hence, it is therefore important to take appropriate preoperative screening and preventive measures for all these patients and to determine which of them warrant additional prophylaxis. Worldwide accepted guidelines on DVT prophylaxis have been produced by the American College of Chest Physicians (ACCP), American Academy of Orthopedic Surgeons (AAOS), and the National Institute for Health and Clinical Excellence (NICE). But the priority consideration is to diagnose the patients with high risk of developing DVT.
The risk factors for the development of DVT can be modifiable or nonmodifiable factors.
Modifiable factors include
Obesity: it is defined as BMI above 30. Obesity leads to a two- to threefold higher risk of venous thrombosis in men and women. The obese have a further increase in thrombosis risk when they are exposed to other thrombosis risk factors, such as exogenous contraceptive or postmenopausal hormones.
Homocysteine levels: elevated homocysteine has been consistently reported as a risk factor for venous thrombosis and levels can be reduced with B vitamin supplementation.
Nonmodifiable risk factors include the genetic factors which cause thrombophilic disorders. Protein C, protein S, and antithrombin deficiencies, Factor V Leiden mutation, and increased level of factor V, VII, VIII, IX, XI and von Willebrand factor are a few of the conditions that add up the risk of DVT.
Triggering factors are incidental situations which put patients into high risk of developing DVT, which cannot be avoided but can be tided over.
Hospitalization—either due to immobility, infection, surgery.
Surgery/trauma.
Immobility—due to stasis of blood flow as in cases of plaster casts, bed rest, and paresis of legs due to neurological conditions.
Cancer—increased risk due to cancer cells activating coagulation and tumors compressing veins causing hemostasis.
Travel—duration of any form of travel more than 4 h increases the risk by about twofold for several weeks after travel [3].
Apart from the history and the classic clinical symptoms and examination findings of pain, tenderness, and swelling of the leg, different techniques are employed to detect even small thrombi in the venous system.
But the point of interest is to prevent the occurrence of DVT rather than its detection. All these modalities are used to detect even a minute thrombus occurring in the system. Apart from the identification of high-risk patients, it would be better to screen all these patients for DVT preoperatively. So many studies have been done in this regard in different population using preoperative Doppler screening studies. According to the Scottish Arthroplasty Registry, the incidence of clinically significant VTE within 3 months of TKA is 1.79%, whereas that of fatal PE is 0.15% [5] and the asymptomatic DVT rates are much higher. Therefore, thromboprophylaxis use has been recommended for all patients undergoing TJA in Western population. Many other regional studies have shown that the incidence of DVT in patients undergoing TKA is so less to warrant a regular preoperative Doppler screening. However, it is said that a better modality to detect thrombi would be venography, which is not an appealing invasive procedure.
Numerous guidelines and recommendations suggest the use of various methods of thromboprophylaxis and methods to reduce the risk of development of modifiable factors. Pharmacological and mechanical prophylaxis methods are used, either in isolation or in combination, to reduce the risk of postoperative VTE.
ACCP 2012 guidelines recommend thromboprophylaxis for patients undergoing TJA for a minimum of 10–14 days. They prefer agents like low molecular weight heparin (LMWH), vitamin K antagonist, aspirin, fondaparinux, apixaban, dabigatran, or rivaroxaban. Regular Doppler screening during postoperative period is not recommended. But, prophylaxis is advocated as it is recognized that asymptomatic DVT can produce a fatal PE [6] (Figure 2).
Highlights of the recent ACCP guidelines for thromboprophylaxis.
The AAOS 2011 guidelines suggest pharmacologic agents and/or mechanical device for the prevention of VTE following joint replacement surgery. They did not recommend any specific agent or duration of thromboprophylaxis. Both guidelines support combined methods of chemoprophylaxis with mechanical device. Also, they discourage the regular Doppler screening for DVT postoperatively [7] (Figure 3).
Highlights of the recent AAOS guidelines for thromboprophylaxis.
Thromboprophylaxis methods can be broadly divided into three—pharmacological, mechanical, and multimodal measures. Pharmacological measures include early active mobilization, intermittent pneumatic compression device (IPCD), compression stockings, and active ankle pumps. Anticoagulants often used are unfractionated and low molecular weight heparins, vitamin K antagonists, and selective factor Xa inhibitor (e.g., fondaparinux).
The most recent amendments to the AAOS, ACCP, and Surgical Care Improvement Project (SCIP) clinical practice guidelines for VTE prophylaxis after total joint arthroplasty now include mechanical compression devices as modalities for VTE prophylaxis. Mechanical compressive devices increase the local blood flow in the lower extremities, decrease the concentration of the activated coagulation factors, and promote lymphatic drainage in adjacent tissues. It avoids the side effects of the anticoagulant drugs such as wound drainage, hematoma, and gastrointestinal and intracranial bleeding and also enhances the effects of anticoagulant.
The new oral anticoagulants and their mode of action.
The advantages of these agents are rapid onset of action, predictable anticoagulant response, no need for monitoring, wider therapeutic index, fewer drug–drug and drug-food interactions, reduced or comparable rates of thrombosis, bleeding, and other adverse events, and being orally administered, it is convenient and compliant. Many studies have come up with conflicting conclusion regarding these molecules.
Figure showing the characteristics of rivaroxaban.
Combining mechanical and pharmacological prophylaxis enables greater reduction of the risk of DTV. It also reduces the dosage of anticoagulants and thus the risk of bleeding, and achieves the same or even better thromboprophylaxis than monotherapy. Classifying patients into low or high risk of developing VTE is advocated. Low-risk patients received aspirin and intermittent calf compression, whereas high-risk patients received LMWH or warfarin and intermittent calf compression. All patients have to be mobilized within 24 h of surgery.
Few studies have advocated less potent pharmacological agents for low-risk patients and more potent agents for high-risk patients as the results showed negligible incidence of DVT, PE, and wound hematoma in both the groups [21]. Few recent studies show superior effects for aspirin in multimodal thromboprophylaxis when compared to warfarin [13, 14, 22].
The risks associated with thromboprophylaxis are mainly hemorrhage, wound hematoma, persisting wound drainage, failure of wound healing, risk of infection, and blood loss requiring transfusion. One of the main drawbacks of initiating thromboprophylaxis is the high incidence of major bleeding, reaching up to 4–7.9% [23]. More potent the prophylactic agent, more the incidence. Oral agents hence have lower bleeding rates [15]. A study on 290 patients post-TJA using 10-day course of inj. enoxaparin 30 mg twice daily showed high incidence of 3–5% of readmission, re-exploration, and prolonged hospitalization for wound drainage and bleeding [24]. There were increased rates of return to the operating room for wound complications, wound drainage for more than 7 days, and incidence of symptomatic DVT in 3.8% patients and nonfatal PE in 1.3% patients. Parvizi et al. reviewed 78 septic failure cases that underwent revision and showed a direct correlation between excessive anticoagulation and development of periprosthetic infection [25]. The occurrence of such complications after elective TJA due to the use of prophylactic agents is heartbreaking to most surgeons.
Also, timing of initiation of the prophylaxis is also debated. Two schools of thought are initiation of LMWH 12 h preoperative and 12 h postoperative. Earlier initiation of prophylaxis has shown greater efficacy in preventing DVT but also causes a higher incidence of bleeding. The decision about which agent and when to initiate chemoprophylaxis should be based on the balanced efficacy-bleeding ratio of the prophylactic agents [26].
There is still no consensus on the duration of the use of prophylaxis too. The recently released new AAOS guidelines do not provide a specific duration for prophylaxis [27]. Earlier ACCP guidelines advocated a minimum of 10 days of prophylaxis, with extended prophylaxis up to 35 days. AAOS advised different duration for different agents: LMWH/fondaparinux for 7–12 days and aspirin/warfarin for 6 weeks. Extended prophylaxis with only LMWH was effective post THA, but not TKA [28].
Ideal DVT prophylaxis method still remains an enigma. The choice is based on patient characteristics and surgeon’s experience. Aspirin is recognized as a primary chemoprophylactic agent with the adaptation of the recent ACCP guidelines by the Surgical Care Improvement Project (SCIP). They strongly endorse risk stratification for VTE prophylaxis and opined that aspirin will become the mainstay of prevention of VTE for the majority of patients after TJA. Thus, we could optimize outcomes for our patients, by preventing the feared VTE while limiting bleeding complications that can occur with other aggressive anticoagulants [29]. Identifying and stratifying the patients at risk for DVT remains a challenge. As a general consensus, it is taken that patients post TJA can receive aspirin as thromboprophylaxis without much risk. But, those patients at very high risk may need more potent agents and careful monitoring [30].
Further research is needed to identify patients at major risk and probability of VTE and bleeding. The current clinical guidelines provide an orthopedic surgeon with more latitude, and choices of VTE prophylaxis without emphasis on aggressive chemical, and often unneeded prophylaxis. The key to determining the appropriate chemical prophylaxis for patients is to balance safety and efficacy while minimizing bleeding. Modern arthroplasty surgeons advocate early postoperative mobilization and use of mechanical prophylaxis in combination with chemoprophylaxis according to the risk stratification, which of course seems to be a reasonable safer approach.
Non-communicable diseases (NCDs) as at 2015 already account for more than 80 percent of premature deaths in developing countries and the reported single largest preventable risk factor for NCDs is tobacco smoking [1]. The transition of tobacco hubs from the West to the African continent is of paramount importance, and Nigeria lies at the forefront of the shift from a tobacco-producing to a tobacco-consuming nation [2]. Smoking is the inhalation of the smoke of burning tobacco encased in cigarettes, pipes, and cigars. Most smokers begin smoking during their adolescent years, and they grow into the habit making nicotine addiction difficult to curb [3]. As these adolescents become adults, they serve as role models to youths, reinforcing a vicious cycle [3]. The health consequences of tobacco smoking depend on the duration and quantity of the smoking behaviour. Starting to smoke early in life increases the risk of NCDs and adolescent smokers are at greatest risk of future morbidity and mortality [4].
This chapter will highlight the prevalence and determinants of smoking in Nigeria, its measured effects on the health and well-being of the citizens, its economic burden, governmental and institutional efforts towards the control of tobacco smoking and the success, if any, of these measures.
There was an astronomic growth in the industry across the globe and consumption was freely rising until 1964 when it witnessed its first set back. The Surgeon General of the USA, Luther L. Terry (MD) issued the first warning dangers on cigarette smoking on January 11th 1964, relating the tar and nicotine content as causes of cancer. His Advisory Committee made their observations and conclusions based on the findings of more than 7,000 articles relating to smoking and disease available at that time in the biomedical literature [6]. They concluded that cigarette smoking was responsible for lung and laryngeal cancers in men, probable cause of lung cancer in women and the most important cause of chronic bronchitis.
The guided restrictions placed on the use of tobacco in Nigeria and other parts of the world were the results of the early steps taken by Luther L. Terry who insisted on warning labels on every cigarette pack [7] which forced tobacco industries to modifying their products by introducing filters and reducing the nicotine contents in their products. The warning labels transformed over years [7] and most developed countries made a stricter conditionality that forced many cigarette companies outside the shores of the US to the developing countries especially in Asia, Africa and South America where they found safe haven to establish their industries.
Generally, the 19th Century was associated with improvement in health research which further revealed other adverse effects of smoking. Subsequently, its ban or reduction in use gained a global attention. Despite the known adverse consequences of tobacco consumption, it is only in the Kingdom of Bhutan (South Asian country) that the sales of tobacco are illegal [8].
Historically, the agenda for a national policy on tobacco control in Nigeria dates back to the pre independence era, it however was not until a decade after the 2005 signing of the World Health Organisation Framework Convention for Tobacco Control (WHO FCTC) [9, 10]. Economic challenge such as lack of fund and loss of employment by the citizens were some of the reasons cited for the delay in implementing the tobacco compliant policy. This is in difference to the observation by Egbe et al. in their 2017 report that focused on and implicated the tobacco industry as the major influence against the implementation of the WHO FCTC since 2005 when Nigeria ratified the FCTC, until 2015 when the National Tobacco Control Act (NTCA) was signed into law [9, 11].
Globally, it is estimated that the number of smokers will increase from the present prevalence of 1.3 billion to 1.6 billion people in 2025. Its associated mortality is estimated to increase to 8.3 million persons in 2030 from 4.8 million persons in 2006 [12]. In 1990, Obot reported a prevalence of 26.8% of current smokers and 4.7% of past smokers among Nigerian adults [13]. According to the 2012 GATS conducted in Nigeria, the overall prevalence of adults who currently smoked was 3.7% [(3.1 million people): 7.2% - males; 0.3% - females)] [14]. The average age at initiation of daily smoking, according to the report showed that majority began after 16 years old [14]. More recent studies among medical, pharmacy and nursing students in South-west Nigeria had life time prevalence of 17.9% and 5.04% for lifetime and current smokers [15]. The undergraduate university students study in Ilorin, North-central Nigeria recorded a similar result, 17.1 and 5.7 prevalence for lifetime and current smokers respectively [16]. The male to female prevalence ratio among current smokers were 3.8:1, male 7.7% and female 2.0%. The mean age at initiation of smoking for males (15.5 ± 2.9, range 10–22 years) was not significantly different from that of females (15.6 ± 3.3, range 10–19 years). A common factor in all the Nigerian studies is male predominance among all categories of smokers [9, 13, 15, 16]. The gender difference may be attributed to societal perception as most African communities see smoking as a sign of masculinity or even specific to manhood and vigour, while social values discourages smoking among women. This is also true in some other African studies such as Ghana [17] and Sudan [18]. Few Nigerian studies and findings from systematic review studies conducted across Sub-Saharan African countries shows no consistent disparity in smoking prevalence between rural and urban populations [19, 20]. Hence, tobacco control policies should be strengthened across all Nigerian societies regardless of geography or existing health or socioeconomic inequalities.
A substantial body of literature has emerged over the last few decades which examined the determinants of smoking behaviour in an economic framework of demand incorporating cigarette prices. Most studies in Nigeria were focused mainly on the determinants without much emphasis on the effect of cigarette pricing. Some of the determinants highlighted include the age of onset, peer group, parental influences, media influence etc. The Nigeria climate and weather favours the cultivation of tobacco in large commercial scale, especially in the South-western part of the country. This agricultural setting may influence tobacco smoking, but little is known about the influence of tobacco leave plantation (agricultural setting) on the incidence and prevalence of tobacco among children and adults in Nigeria.
One important determinant of cigarette smoking with perhaps the highest immediate and long term consequences is the age. Early age at debut implies that the smoker will not only have longer time over which his/her tolerance levels can increase but also that the period of exposure to cigarette smoking with subsequent complications will be high. On the average, at the turn of thirty years of age, the rate of decline in the functional capacities of human organ-system is at about 0.1% annually. This modest decline is lost and the downward trend as high as 1% annual decline is seen in those with one form of existing morbidities or harmful lifestyle practices such as cigarette smoking.
Age of smoking debut is around 15 years in Nigeria and by age 17, a persistent smoking pattern is already established and a significant 15% smoking prevalence among the adolescents [21, 22]. The male to female prevalence ratio among current smokers were 3.8:1, male 7.7% and female 2.0%. The mean age at initiation of smoking for males (15.5 ± 2.9, range 10–22 years) was not significantly different from that of females (15.6 ± 3.3, range 10–19 years) [16]. The driving force for the onset age of smoking among Nigerian children depends on the population being under study, whether out-of-school youths or in-school youths. For the out-of-school youths, psychosocial factors such as belonging to a polygamous home, low level of fathers’ education, feeling loneliness in the face of weak family bonds and harsh survival realities plays an initial dominant factor, coupled with peer pressure with the attendant high prevalence of smoking among the group [20, 23]. Since these psychosocial problems are usually due to physical, emotional and sexual abuse and neglect, they usually resort to tobacco smoking or other forms of substance abuse as a coping mechanism to ameliorate their condition. And among the in-school youths, the onset age of smoking is influenced by peer pressure and media influences. Additional risk factors in both groups are family conditions, such as low parental education, polygamy, not living with parents, having a parent who smokes and having divorced or separated parents [20]. Older studies in Nigeria and other developing countries in Africa were in agreement with the findings regarding early initiation of the youths into the act of cigarette smoking. Early commencement of smoking in high schools within Nigeria was reported in several works in this field [24, 25, 26]. The path to addiction commonly commences from this stage (the initiation phase) and by the age of 21 (in the university), the cigarette uptake process is mostly completed [27]. This trend of early initiation into cigarette smoking has been related to the highly addictive nature of cigarette and tobacco related substances.
Studies suggest that age at smoking initiation is related to subsequent aspects of smoking behaviour, such as cigarette consumption, nicotine dependence and smoking cessation [28]. Breslau predicted that the probability of smoking cessation among adults is inversely related to age at initiation [29].
Reports have shown that initiation into smoking and other dangerous life styles majorly occurs at the adolescent age [24, 25, 26, 30]. The disease burden emanating from chronic cigarette smoking is quite enormous. A recent report placed the current cost of medical treatment and low productivity emanating from cigarette smoking in Nigeria at five hundred and ninety-one million dollars ($591 M) per annum [31]. This is capable of significantly eroding the gains and advantages of a young population in growing economy like ours. Therefore the policy formulators must painstakingly exercise every right to inform and protect this group of individuals at all times.
Environmental factors also known as behavioural factors that are important in smoking prevalence can be found in the familiar (shared) or individual-specific (unshared) environment. The familiar environment is more likely to influence a smoker if anyone in his immediate environment is smoking such the parent(s). Parental influence could be direct (when the parent is a smoker) or indirectly (when parents are uninvolved in the affairs of their children).
A study in Port Harcourt Nigeria attributed 6.3% of the adolescent smokers, in their recent survey, to parental influence [32]. This factor ranked fourth behind Experimental exposition, Peer Influence and Advertisement. They reiterated the role of parents in moulding the characters of their children/wards against cigarette smoking, a factor though not as strong as peer influences and experimental expositions [32]. There is also some contribution by religiosity and the culture of the region which can influence the family/societal values and traditions and in the long run an individual’s smoking habit.
A study among secondary school students in the Southwest Nigeria established a very strong relationship between the students smoking behaviour and those of their parents among other factors [24]. The study posited that parental influence (p = 0.002856) played significant role in the adoption of smoking behaviour by youths. They further advised that enlightenment and rehabilitation programmes targeted against cigarette smoking should also involve parent smokers to ensure effective outcome [24].
The peer influence has been observed to have a higher influence on smoking initiation and persistence [33, 34]. Powell et al., used the peer effect model in their study on tobacco control policies and youth smoking behaviour; to establish that peer effects play a significant role in youth smoking decisions [35].
The numbers of hours people watch television have also been shown to influence the smoking habits and initiation [26]. Television programs depicting tobacco usage may encourage smoking among adolescents, however the converse was observed in an Iraq study [36]. Although bans have prevented direct tobacco advertising on television, studies have indicated the widespread portrayal of smoking on television on prime-time programming, movies, music videos, and sporting events. Rarely is smoking portrayed as a negative influence or unattractive, thus making television an indirect means of smoking advertising [33].
The presence of legislation against smoking also determines smoking habits. This will limit the availability and youth access to cigarettes, elevate the age of onset of smoking, ensure a smoke-free indoor air and thus reduce the adverse effects of tobacco on the smoker and passive smokers. Chaloupka studied the effects of limits on youth access on smoking rates controlling for their enforcement and compliance [38]. He found that most state and local tobacco control policies did not have statistically significant effects on youth smoking except when strong restrictions exist. However, the combined effect of all non-tax policies on smoking participation was significant [37, 38]. Studies have concluded that strong smoking restrictions significantly reduced both smoking prevalence and average daily cigarette consumption among young adults [39, 40]. In fact a strict enforcement against cigarette smoking for 20 years in Brazil resulted in a 50% cut in prevalence of smoking among the young adults [40]. This is probably why in developed countries, where there is strong political will against the act of smoking, a decreasing prevalence of smoking is being documented [35].
Furthermore, individual-specific environmental factors include factors like mood and general state of health play significant role. Depressed individuals tend to smoke more and a history of major depressive disorder is associated with a lower chance to quit smoking [41]. Personal feeling of insecurity, insomnia, loneliness and feeling of grandeur all increase affiliation to cigarette smoking. On the other hand, sudden diagnosis of an ailment can encourage a current smoker to quit.
Some people may associate a particular status with smoking. They feel that smoking brings respect and is an acknowledgment of superiority. Finally, defiance to authority can be a factor that influences smoking. Some children tend to show disagreement/rebellion against parents, teachers or designated authorities through smoking [36]. These factors cannot be quantified and may confound with one another.
Cigarette smoke is a complex mixture of chemicals. It is believed that the reason why people smoke is due to the active ingredient in the tobacco, nicotine which acts as a stimulant and a relaxant through its effects on the central nervous system, adrenals and the sympathetic nervous system [42, 43]. When a cigarette is smoked, nicotine-rich blood passes from the lungs to the brain within seven seconds and immediately stimulates the release of many chemical messengers including acetylcholine, norepinephrine, epinephrine, vasopressin, arginine, dopamine, autocrine agents, and beta-endorphin [42, 43]. This release of neurotransmitters and hormones is responsible for most of the effects of nicotine. Nicotine appears to enhance concentration and memory due to the increase of acetylcholine. It also appears to enhance alertness due to the increases of acetylcholine and norepinephrine. Arousal is increased by the resultant elevated level of norepinephrine. Pain is reduced by the increases of acetylcholine and beta-endorphin. Anxiety is reduced by the increased beta-endorphin. Nicotine also extends the duration of positive effects of dopamine and increases sensitivity in brain reward systems [44, 45]. This is one of the key reasons why cigarette is very addictive.
Some smoke components, such as carbon monoxide (CO), hydrogen cyanide (HCN), and nitrogen oxides, are gases. Others, such as formaldehyde, acrolein, benzene, and certain N-nitrosamines, are volatile chemicals contained in the liquid-vapour portion of the smoke aerosol. Still others, such as nicotine, phenol, polyaromatic hydrocarbons (PAHs), and certain tobacco-specific nitrosamines (TSNAs) are contained in the submicron-sized solid particles that are suspended in cigarette smoke. In view of this chemical complexity, cigarette smoke has been shown to have multiple and highly diverse effects on human health. These adverse effects have been documented in literature to involve every organ in the human body culminating in various cancers, chronic obstructive pulmonary airway disease to various cardiovascular diseases. It has also been linked with auditory problems [46] while in India and China it has been associated with increased prevalence in pulmonary tuberculosis [47].
The use of tobacco has been reported to be associated with increased chronic lung diseases, asthma, angina depression, arthritis, diabetes, hypertension and cerebrospinal accidents [45, 46, 47, 48, 49, 50, 51]. The adverse economic effect of tobacco smoking is huge [5, 52, 53]. In the United States, an estimated $96 billion per annum were being incurred from tobacco use and related medical expenses due to loss of productivity and over $2 billion would be saved annually from healthcare insurance if all smokers in the US were to quit smoking [54].
The Youths are the most effective groups targeted by public/health policy makers and economists for smoking prevention programmes, since almost all first use of cigarettes occur at this age and the development of addictive habits also begins at this age. Health policy designed to discourage the use of Tobacco products especially in this age group was signed and approved by many countries including Nigeria, under the aegis of the WHO Framework Convention on Tobacco Control (WHO FCTC) of 2005. The WHO Framework Convention on Tobacco Control (FCTC), was adopted by the 56th World Health Assembly on May 21, 2003, and implemented on February 27, 2005. In this treaty, WHO recommends a four-pronged strategy for the control of smoking. The first prong advocates a ban on all forms of advertising and an increase in public health information with special attention to youths. By 2008, WHO revealed a six evidenced-based policy package known as “MPOWER” through which the FCTC could be implemented. This acronym stands for (i) Monitor tobacco use and prevention policy, (ii) Protect people from tobacco smoke, (iii) Offer help to quit tobacco use, (iv) Warn people about the dangers of tobacco, (v) Enforce bans on tobacco advertising, promotion and sponsorship, and (vi) Raise taxes on tobacco.
The MPOWER also seeks to enhance price and excise tax policy, smoke-free indoor air laws, laws restricting access of minors to tobacco (including retail tobacco licencing), advertising and promotion restrictions on tobacco products, requirements for warning labels on tobacco products, and requirements for product ingredient disclosure [55]. It provides a practical measure for countries wishing to reduce demand for tobacco in line with WHO FCTC [55]. According to the 2013, WHO Report on the Global Tobacco Epidemic, a third of the world’s population is covered by at least one measure of the MPOWER at the highest level. Turkey is the only country at present protecting its entire population with all MPOWER measures at the highest level [56].
Global Adults Tobacco Survey (GATS) report, a component of the Global Tobacco Surveillance System (GTSS), an initiative of the WHO is used by countries to collect data on adult tobacco use and MPOWER measures [14]. In Nigeria, the 2012 survey report which targeted adults aged 15 and older, showed a generally below average indices to the MPOWER measures [14]. This was compounded by the prolonged delay in signing the tobacco smoking bill into law and currently the procrastination in the operationalization and enforcement of the law.
One of the factors that influence consumers in a market economy is price, and the law of demand that defines the typical relationship between price and quantity demanded states that ‘consumers will demand more of a particular product at a lower price, and less at a higher price’ [37]. This may not entirely apply to cigarette smoking due the associated addiction. The price elasticity of demand measures the responsiveness or sensitivity of the quantity demanded of a particular product to changes in its price [37]. In relation to smoking, there is need to understand how price adjustment will affect the demand for cigarettes. Hence, this will help define the influence of price adjustment as control measure for control of cigarette smoking among the youths.
With effective control measures in place, the rate of tobacco consumption has been stabilised in developed nations between 1970 and 2000. Unfortunately, there has been tremendous increase in consumption rate in the developing countries. Leder and Esson had projected that within the next 25 years the rate of smoking would have increased by 60% and 100% respectively in countries of Medium and Low level human developments respectively [55]. Fifty percent of the mortality from cigarette smoking was projected to involve the productive age groups (35–69 years) which is a great set back to the socioeconomic development of these countries. Nigeria being a part of the WHO FCTC and in the bid to curb this trend, it is necessary to find out the impact of this anti-smoking policy on smoking behaviour of young people.
It will be sufficed to say that; passive smoking is also a challenge in Nigeria as overall prevalence in the home was 24.1%, while it stands at 43.0% in non-home areas including public places [57]. The health impact of this is also enormous which include but not limited to lung cancers, stroke, triggering of asthmatic conditions, TB infections and progression to TB diseases, stroke, chronic obstructive pulmonary diseases, cardiovascular diseases [58]. In 2008, Federal Capital Territory (FCT), Abuja passed most comprehensive public ban on smoking, followed by Lagos State [57]. This ban outlawed smoking in all communal areas including restaurants, bars and workplaces. The National Tobacco Act later provide new opportunities for broad scale reduction in passive smoking exposure in public places at the national level.
In Nigeria, the first law on tobacco regulation was in the Section 6 of the Nigeria (Constitution) Order-in Council of 1954 but it was essentially designed to make provisions for licencing and payment of duties of Tobacco importation. Presently, the only law in-place which also legislates on the consumption and advertisement of tobacco is the “Tobacco Smoking (Control) Decree No. 20 of 1990”. It prohibits smoking in public places including schools, public transportation, stadium, theatres, medical establishment etc. It also stipulates restrictions on tobacco advertisements and provides penalties for smokers, sellers and advertisers that do not conform to the provisions [20]. Unfortunately a smoking age limit and the restriction of cigarette sales to or by minor are not provided for in this law. The presence of the so called warnings like: “The Federal Ministry of health warns that Tobacco smoking is dangerous to health” or “Smokers are liable to die young”; appear insufficient since the minors do not understand the implications. The enforcement of the existing law is another questionable issue. The agitations on the existing inefficient anti-smoking laws in Nigeria culminated in the recent commencement of legislative process for the review of the present Tobacco Smoking (Control) Decree No. 20 of 1990. This bill sort for an act to repeal the Tobacco smoking Control Act 1990, CAP. T6 Laws of the Federation and to enact the National Tobacco Control bill 2012 to provide for the regulation and control of production, manufacturing, sale, advertising, promotion and sponsorship of tobacco products in Nigeria and other related matters. The public hearing was held at the National Assembly Complex on 15th October 2014. It was finally passed into law by the legislatures and received the presidential assent on May 27th 2015. The Nigeria National Tobacco Control Act of 2015, was passed to domesticate the WHO FCTC; however, implementation has been poor as most public places are yet to be smoke free, and no funds have been dedicated for tobacco law enforcement. Currently the bureaucratic processes involving the operationalization of the Act is ongoing. The operationalization of this Act needed to be given a deserved attention as report shows half of adolescent smokers become regular smoking adults, and a further half of this population is expected to die of tobacco-associated illnesses, further highlighting the great burden smoking in young poses and the need to end this habit [20]. Hopefully, when the law becomes effectively operationalised and implementation enforced, it will help in reducing the tides of smoking with its attendant health risk.
The health hazards of smoking and the impact on quality of life should be part of focus on tobacco control initiatives for youths. Former smokers should be involved in active antismoking campaigns and the factors that made them quit should be taken into consideration when designing anti-smoking measures.
Tobacco smoking poses a huge burden to Nigerian youths (the most populous country in Africa) and the high prevalence and various determinants were reported. Following the 2003 World Health Organisation (WHO) Framework Convention on Tobacco Control (FCTC), Nigeria ratified the convention agreement in 2005, and in 2015 signed into law the National Tobacco Control (NTC) Act that regulates all aspects of tobacco control including advertising, packaging, and smoke-free areas. A thriving tobacco market raises serious public health concerns, particularly for a country with a relatively weak health system.
Careful implementation of smoke-free legislation (targeted at reversing tobacco epidemic) beyond the national level to state and local levels may complement successful measures like taxes, health education and media campaigns. Besides, Nigeria needs to develop comprehensive surveillance systems to monitor the production, sales, and consumption of cigarettes to effectively achieve control targets. It is imperative that all stakeholders engage in concerted efforts in tobacco control strategies.
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In the description of the chemical analysis and the chemical pollutant removal methods, the evaluation of the unsuitableness or suitableness toward some of the Green Chemistry principles are also accompanied. 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This review merely focusing on eco-friendly protocol which replace the traditional method of synthesis followed in chemistry to synthesize lifesaving drugs, with prevention outgoing waste from industries. GC and chemical engineering or green engineering (GE) should produce eco-friendly chemical process for drug design which likely to be spread rapidly in next few decades. 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A case study is subsequently proposed, applying this methodology to a cross-comparison on the results of five contemporary experiments on HRTF learning. The objective is to propose a set of steps and metrics to allow for a systematic assessment of participant performance (baseline, learning rates, foreseeable performance plateau limits, etc.) to ease future inter-study comparisons.",book:{id:"10370",title:"Advances in Fundamental and Applied Research on Spatial Audio",coverURL:"https://cdn.intechopen.com/books/images_new/10370.jpg"},signatures:"David Poirier-Quinot, Martin S. Lawless, Peter Stitt and Brian F.G. Katz"},{id:"81356",title:"Wind Turbine Aerodynamics and Flow Control",slug:"wind-turbine-aerodynamics-and-flow-control",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.103930",abstract:"Aerodynamics is one of the prime topics in wind turbine research. In aerodynamics, the design of a flow control mechanism lays the foundation for an efficient power output. Lift generation in the airfoil section leading to rotary motion of blade and transfer of mechanical to electrical power generation through gearbox assembly. The primary objective of a flow control mechanism in wind turbine blades is to delay the stall and increase the lift, thereby an efficient power generation. Flow control is classified into active and passive flow control mechanisms. Active flow control works on an actuation mechanism that comes into action when required during varied operating conditions. Passive flow control devices are designed, developed, and fixed on the surface to extract the required output through effective flow control. Vortex generators are the simplest, most cost-effective and efficient passive flow control devices. These devices influence the power of wind turbine blades in various ways, such as placement of generator along the chord, distance between pairs of a generator, angle of inclination of a generator with the blade surface, the height of generator. 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Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. 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This group of bio-inspired metaheuristics solves multiple optimization problems by applying the metaphor of natural selection. It so far has solved problems such as resource allocation, routing, schedule planning, and engineering design. Moreover, in the field of machine learning, evolutionary computation has carved out a significant niche both in the generation of learning models and in the automatic design and optimization of hyperparameters in deep learning models. This collection aims to include quality volumes on various topics related to evolutionary algorithms and, alternatively, other metaheuristics of interest inspired by nature. For example, some of the issues of interest could be the following: Advances in evolutionary computation (Genetic algorithms, Genetic programming, Bio-inspired metaheuristics, Hybrid metaheuristics, Parallel ECs); Applications of evolutionary algorithms (Machine learning and Data Mining with EAs, Search-Based Software Engineering, Scheduling, and Planning Applications, Smart Transport Applications, Applications to Games, Image Analysis, Signal Processing and Pattern Recognition, Applications to Sustainability).",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11421,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"111683",title:"Prof.",name:"Elmer P.",middleName:"P.",surname:"Dadios",slug:"elmer-p.-dadios",fullName:"Elmer P. 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Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:287,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/427636",hash:"",query:{},params:{id:"427636"},fullPath:"/profiles/427636",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()