Yi Guo

Beijing Tsinghua Chang Gung Hospital

My background and training is in the neurological surgery. I have direct experience in performing brain arteriovenous malformation (BAVM) surgeries. I am familiar with the clinical phenotype of BAVM. I was doing basic research on BAVM and spinal AVMs under Dr. Yuanli Zhao and Dr. Guihuai Wang’s supervision. During I was Ph.D candidate and postdoctoral fellow, my research interests are focused on searching the new angiogenic factor may be involved in aberrant angiogenesis and collagen subtypes change in abnormal vessels that may predict hemorrhagic stroke in patients with AVMs. Based on our preliminary results, we found the ratio of collagen type I / type III of abnormal vessels was increased when compared with the normal controlled vessels, this change may increase the abnormal vessels stiffness, together with hemodynamic stresses, it may be the hemorrhagic factor of BAVM. We found silent intralesional microhemorrhage is a novel hemorrhagic risk factor in unruptured BAVM. We also confirmed the distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation, revealed inflammation might be another risk rupture factor in BAVM. In traumatic brain injury research, I focused on clinical application of cisternostomy and basic research of glymphatic system. I finished resident training in the department of neurosurgery of Affiliated Hospital of Hebei University, and worked there as Attending and deputy director. After 2015, I worked in the department of neurosurgery of Beijing Tsinghua Changgung Hospital. My subspeciality is cerebrovascular and Trauma. B. Positions and Honors Research and Professional Experience 1998-2002 Resident, Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding, China 2002-2005 Master in Medical Science, Hebei Medical University, Shijiazhuang, China 2005-2007 Fellow, Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding, China 2007-2008 Fellow, Beijing College of Neurosurgery, China 2008-2015 Clinical Associate Professor, Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding, China 2009-2012 PhD, Beijing Tiantan Hospital, Capital Medical University, China 2011-2012 Research Neuroscientist, Center for Cerebrovascular Research, UCSF, USA 2014.6-2014.8 Visiting Scholar, Department of Neurosurgery, UCSF, USA 2014.8-2014.9 Visiting Scholar, Department of Neurosurgery, St. Joseph's Hospital and Medical Center, Phoenix, USA 2015-Present Clinical Associate Professor, Department of Neurosurgery, Tsinghua University Affiliated Beijing Tsinghua Changgung Hosptial. China. 2016-2018 Postdoctoral Fellow, School of Medicine, Tsinghua University. 2021-Present Deputy director, Department of Neurosurgery, Tsinghua University Affiliated Beijing Tsinghua Changgung Hosptial. China. Other Experience and Professional Memberships 1998-Present Member, Chinese Medical Association 2013-Present Reviewer for Asian Journal of Neurosurgery. 2014-Present Life member of Asian Congress of Neurosurgical Surgeons. 2018-Present Member of Western Returned Scholars Association (Overseas-educated Scholars Association of China) Honors and Awards 1993-1997 Clinical Medicine Departmental Scholarship, Chengde Medical College 2002-2003 Postgraduate Departmental Scholarship, Hebei Medical University 11/2010 Full Young Neurosurgeons (YNS) Sponsorship for 8th Asian Congress of Neurological Surgeons, Kuala Lumpur, Malaysia C. Relevant Peer-Reviewed Publications 1. Guo Y, Xu B, Sun Z, Wu Y, Shi W, Wang J, Meng X, Ge W, Wang G.Quantitative protein profiling and pathway analysis of spinal arteriovenous malformations.Microvasc Res. 2018 Jun 11. pii: S0026-2862(18)30041-4. 2. Di H, Zhang X, Guo Y, Shi Y, Fang C, Yuan Y, Wang J, Shang C, Guo W, Li C.Silencing LDHA inhibits proliferation, induces apoptosis and increases chemosensitivity to temozolomide in glioma cells. Oncol Lett. 2018 Apr;15(4):5131-5136. 3. Jing L, Su W, Guo Y, Sun Z, Wang J, Wang G. Microsurgical treatment and outcomes of spinal arteriovenous lesions: Learned from consecutive series of 105 lesions.J Clin Neurosci. 2017 Dec;46:141-147. 4. Wang X, Hao Q, Zhao Y, Guo Y, Ge W. Dysregulation of cell-cell interactions in brain arteriovenous malformations: A quantitative proteomic study. Proteomics Clin Appl. 2017 May;11(5-6). 5. Xu B, Tian R, Wang X, Zhan S, Wang R, Guo Y, Ge W. Protein profile changes in the frontotemporal lobes in human severe traumatic brain injury. Brain Res. 2016 Apr 8. pii: S0006-8993(16)30199-8. doi: 10.1016/j.brainres.2016.04.008. 6. Yang L, Guo Y, Wen D, Yang L, Chen Y, Zhang G, Fan Z. Bone fracture enhances trauma brain injury. Scandinavian Journal of Immunology. 2016,83(1):26-32.. 7. Zhao Q, Guo Y, Yang D, Yang T, Meng X. Serotonin Transporter Gene 5-HTTLPR Polymorphism as a Protective Factor Against the Progression of Post-Stroke Depression. Mol Neurobiol. 2015 Feb 21. PMID: 25700622. 8. Ma L, Guo Y, Zhao YL, Su H. The role of macrophage in the pathogenesis of brain arteriovenous malformation. Int. J. Hematol Res. 2015; 1(2):52-56. 9. Guo Y, Tihan T, Kim H, Hess C, Lawton MT, Young WL, Zhao YL, Su H. Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation. Neuroimmunol Neuroinflammation. 2014; 1(3): 148-153. 10. Cherian Y, Ghuo Y, Munakomi S. Cisternostomy – Replacing the age old Decompressive hemicraniectomy ?. Asian J Neurosurg. 2013; 8(3): 132-138. 11. Cooke DL, Su H, Sun ZhD, Guo Y, Guo D, Saeed MM, Hetts SW, Higashida RT, Dowd CF, Young WL, Halbach VV. Endovascular biopsy: Evaluating the feasibility of harvesting endothelial cells using detachable coils. Interv Neuroradiol. 2013 Dec 20;19(4):399-408 12. Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen FX, Jun K, van Rooijen N, Gressens P, Young WL, Su H. Bone Fracture Exacerbates Murine Ischemic Cerebral Injury. Anesthesiology. 2013 Jun;118(6):1362-1372. PMID: 23438676. 13. Chen W, Guo Y, Walker EJ, Shen F, Jun K, Oh SP, Degos V, Lawton MT, Tihan T, Davalos D, Akassoglou K, Nelson J, Pile-Spellman J, Su H, Young WL. Reduced Mural Cell Coverage and Impaired Vessel Integrity After Angiogenic Stimulation in the Alk1-deficient Brain. Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):305-10. PMID: 23241407. (SCI,IF=5.533) 14. Guo Y, Qumu SW, Nacar OA, Yang JY, Du J, Belen D, Pan L, Zhao YL. Human brain arteriovenous malformations are associated with interruptions in elastic fibers and changes in collagen content. Turk Neurosurg. 2013;23(1):10-5. PMID: 23344861. 15. Guo Y, Saunders T, Su H, Kim H, Akkoc D, Saloner DA, Hetts SW, Hess C, Lawton MT, Bollen AW, Pourmohamad T, McCulloch CE, Tihan T, Young WL; for the University of California, San Francisco Brain Arteriovenous Malformation (UCSF bAVM) Study Project. Silent Intralesional Microhemorrhage as a Risk Factor for Brain Arteriovenous Malformation Rupture. Stroke. 2012 May;43(5):1240-6 PMID: 22308253. 16. Hasan DM, Amans M, Tihan T, Hess C, Guo Y, Cha S, Su H, Martin A, Lawton MY, Neuwelt E, Saloner D, Young WL. Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation. Transl Stroke Res. 2012 Jul;3(Supplement 1):166-173. 17. Guo Y, Su H, Kim H, Lawton MT, Bollen A, Young WL. (Abstract). Inflammatory cell infiltration correlates with hemosiderin deposition (intra lesion hemorrhage) in surgical excised unruptured human brain arteriovenous malformations. International Stroke Conference, New Orleans, LA 2012. 18. Guo Y, Qumu SW, Yang JY, Du J, Pan L, Zhao YL. (Abstract). Histologic Changes of Collagen-elastic Network in Cerebral Arteriovenous Malformations. 8th Asian Congress on Neurological Surgeons, Kuala Lumpur, Malaysia 2010.