Decrease of prevalence of
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"740",leadTitle:null,fullTitle:"Neck Dissection - Clinical Application and Recent Advances",title:"Neck Dissection",subtitle:"Clinical Application and Recent Advances",reviewType:"peer-reviewed",abstract:"Neck Dissection - Clinical Application and Recent Advances is a leading book in neck surgery and represents the recent work and experiences of a number of top international scientists. 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He has had many publications and contribution to science by advocating many surgical procedures and research in cancer surgery and flap reconstruction, TMJ surgery and maxillofacial injuries, orbit tumors and missile war injuries of the face with advancing surgery of war injuries of the face worldwide. He has contributed to research in cancer and has developed post graduate studies in maxillofacial surgery in Iraq. He is the Editor of Neck Dissection - Clinical Application and Recent Advances (February, 2012, IntechOpen), Surgical Reconstruction of the Temporomandibular Joint (2013), Germany, Editor of the book Disease of the TMJ, Surgical Reconstruction, Clinical & Experimental Studies (April, 2014, Science PG), Missile War Injuries of the Face, Maxillofacial Injuries in Road Traffic (book published by Science PG, 2014), and Jaw Lymphoma and Orofacial Tumors (2015, book published by Science PG), editor of the book "Bone Grafting - Recent Advances with Special References to Cranio-Maxillofacial Surgery" (December, 2018, IntechOpen), editor of the book Craniofacial Deformity and Normal Variations of Jaws Relationship (OMICS International, in press). He is Co-editor of the book Maxillofacial Surgery and Craniofacial Deformity (2020, IntechOpen). 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It is an important documentation of air quality and its impact on human health.",isbn:"978-1-78985-280-6",printIsbn:"978-1-78985-279-0",pdfIsbn:"978-1-78984-172-5",doi:"10.5772/intechopen.77883",price:100,priceEur:109,priceUsd:129,slug:"atmospheric-air-pollution-and-monitoring",numberOfPages:98,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"2538dc9777b41324f25fe3c6e26df425",bookSignature:"Abderrahim Lakhouit",publishedDate:"April 15th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/8052.jpg",keywords:null,numberOfDownloads:4590,numberOfWosCitations:0,numberOfCrossrefCitations:3,numberOfDimensionsCitations:5,numberOfTotalCitations:8,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"January 17th 2019",dateEndSecondStepPublish:"March 6th 2019",dateEndThirdStepPublish:"May 5th 2019",dateEndFourthStepPublish:"July 24th 2019",dateEndFifthStepPublish:"September 22nd 2019",remainingDaysToSecondStep:"3 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"250788",title:"Dr.",name:"Abderrahim",middleName:"A.L",surname:"Lakhouit",slug:"abderrahim-lakhouit",fullName:"Abderrahim Lakhouit",profilePictureURL:"https://mts.intechopen.com/storage/users/250788/images/system/250788.jpg",biography:"Dr. Abderrahim Lakhouit has a PhD in Civil and Environmental\nEngineering from the University of Sherbrooke, Quebec, Canada. He has two master’s degrees in Environmental Engineering\nand Renewable Energy and Energy Efficiency. He is an assistant\nprofessor at the University of Tabuk, Kingdom of Saudi Arabia.\nPreviously he worked as a teaching assistant at Canadian universities. Dr. Lakhouit is also a researcher and has published articles\nin international journals such as Chemosphere. He is an associate and guest editor\nas well as reviewer for many international journals, including Waste Management,\nEnvironments, and others. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"38946",title:"Toxoplasma gondii Infection in South-East Europe: Epidemiology and Epizootiology",doi:"10.5772/50831",slug:"toxoplasma-gondii-infection-in-south-east-europe-epidemiology-and-epizootiology",body:'Toxoplasmosis is a globally distributed parasitic zoonosis. Cats and other
This chapter reviews the epidemiology and epizootiology of
We analysed epidemiological data published in the last 20 years for all SEE countries except Bulgaria and Bosnia & Herzegovina for which none were available. Data in the published reports were obtained using a wide array of immunodiagnostic assays which may somewhat limit comparisons. Indeed, the tests in use have varied over time both among and within individual countries, and included the Sabin-Feldman test (SFT), complement fixation test (CFT), indirect fluorescence (IFAT) to direct agglutination (DA) and ELISA, whether in-house or commercial; the latter ones were obtained from various manufacturers. However, this limitation applies to any such review (Gilbert & Peckham, 2002), and moreover, the pattern of infection observed in the region despite the variety of tests with their different specificities, sensitivities, cut-offs etc., rather emphasizes the described trends.
The vast majority of epidemiological data on toxoplasmosis in SEE comes from studies in women of generative age, and a few from studies in immunocompromised patients.
Data on the prevalence of
Continuous monitoring of the prevalence of
Prevalence of
A decreasing trend of
It appears that, according to reports from the eastern part of the region, there is a north-to-south decrease in the infection prevalence (Table 1). For instance, in 1994, the prevalence ranged from 69% in southern Hungary (as a region neighbouring the SEE to the north) (Szénási et al., 1997), over 53% in Serbia (Bobić et al., 2003) to 26% in northern Greece (Diza et al., 2005). This trend was also evident within SEE in all years for which comparative data were available (2002: Serbia 36%, FYRoM 25%; 2004: Serbia 32%, Northern Greece 20%; 2007: Serbia 31%, Northern Greece 21%) (Cvetković et al., 2003; Diza et al., 2005; Bobić et al., 2007; Kansouzidou et al., 2008; Bobić et al., 2011). Moreover, a significant north-to-south decrease in the infection prevalence was also shown within Serbia itself (Bobić et al., 2003). The north-to-south decrease in the prevalence of infection within SEE suggests a possible influence of climatic conditions, which vary across the region from continental to Mediterranean, and over time as well.
1991 | 73% (1) | 69% (2) | ||
1992 | 70% (1) | 75% (2) | ||
1993 | 64% (1) | 58% (2) | ||
1994 | 69% (1) | 53% (2) | 26% (6) | |
2002 | 36% (3) | 25% (4) | ||
2004 | 32% | 20% | 20% (6) | |
2007 | 31% | 21% (7) |
Decrease of prevalence of
Seasonality of infection was examined in Slovenia (Logar et al., 2005) in the west and Serbia (Bobić et al., 2010) in the east. Both studies showed a strong seasonality, with significantly more cases of acute infection in the winter than in the summer months (Fig. 2). In Slovenia, seasonality of infection was attributed to "more frequent and closer contacts with potentially
Seasonality of
Accordingly, the decrease in the prevalence of
Toxoplasmosis is a major opportunistic infection causing life-threatening disease in immunocompromised individuals, which is considered to be a consequence of reactivation of previously latent infection. Although opportunistic infection due to
Although the population structure of
Strategies for the prevention of CT include general screening-in-pregnancy programs and health education, and countries with a low prevalence of infection generally opt for health education (Kravetz et Federman, 2005; Gilbert and Peckham, 2002), while those with a high prevalence adopt screening-in-pregnancy programs (Aspöck & Pollak, 1992; Thulliez, 1992). In the SEE, a systematic program for the prevention of CT based on serological screening of pregnant women and health education has been implemented in Slovenia, while no other country has a systematic prevention program (Logar et al, 2002). The changing pattern of infection across the region currently complicates the choice of prevention strategy. A decrease in the prevalence of infection in women of childbearing age implies a rising proportion of women susceptible to infection in pregnancy, which, in turn, may lead to an increase in the incidence of congenital infections. Indeed, an increase in the incidence of primary infections in pregnancy has been shown through systematic screening-in-pregnancy programs; in Austria, which has been screening all pregnant women ever since 1975, the decrease in
The decreasing prevalence of
Health education is an adequate preventive measure for uninfected immunocompromised patients too.
Epizootiological surveillance of
Throughout SEE, few data are available on
The data on strain isolation in animals are scarce; researchers in Bulgaria have reported isolation of both virulent and avirulent strains of
Earlier serological investigations of various animal species in SEE countries showed a prevalence of 37% for cattle, 30% for sheep, 26% for pigs, 17% for horses, 41% for dogs, 25% for cats, 52% for house mice and 20% for rats in Serbia, but except for pigs, they were carried out on samples of limited size (Šibalić, 1977). In Bulgaria, Nankov (1968) has shown a 15.7% prevalence in hares, and Arnaudov (1971, 1973) reported a prevalence of 32.6% for sheep and 27.2% for goats.
An overview of studies of
As in humans, and similar to the rest of Europe and elsewhere (Tenter et al., 2000; Hall et al., 2001), data on the prevalence in animals vary quite widely in SEE. The highest prevalence has been reported for cattle, sheep and goats (Table 2). While farming practices are similar throughout the SEE region, differences within the region mostly occur in the climatic conditions and terrain characteristics.
The single nation-wide survey on
Croatia | Goats | 79 | 13.9 | MAT (1:20) | Farms | Rajković-Janje et al., 1993 |
Goats | 100 | 4 | MAT (1:20) | Farms | ||
Σ Goats | 179 | 8.4 | MAT (1:20) | Σ | ||
Sheep | unknown | 11.6 (sheep) 9.4 (lambs) | DAT | Farms | Rajković-Janje et al., 1994 | |
Sheep | unknown | 0.5 | DAT | Nomadic | ||
Σ Sheep | 334 | 4.8 | DAT | Σ | ||
Sheep | unknown | 48.4 | ELISA | 10 farms | Marinculić et al., 1997 | |
Chickens | 716 | 0.4 | Bioassay | Abattoir | Kutičić & Wikerhauser, 2000 | |
Rats | 142 | 1.4 | Bioassay | Pig farms | Kutičić et al., 2005 | |
Mice | 86 | 0 | Bioassay | Pig farms + households | ||
Serbia | Cattle | 611 | 76.3 | MAT (1:25) | Farms + abattoir | Klun et al., 2006 |
Sheep | 511 | 84.5 | MAT (1:25) | Farms | ||
Pigs | 605 | 28.9 | MAT (1:25) | Farms + abattoir | ||
Horses | 250 | 30.8 | MAT (1:25) | Farms | Klun, 2005 | |
Sheep | 367 | 7.1 | unknown | Aborting sheep | Vidić et al., 2007 | |
Sheep | 30 | 36.7 | IFAT (1:20) | Farm | Lalošević et al., 2008 | |
Pigs | 488 | 9.2 | MAT (1:25) | Abattoir | Klun et al., 2011 | |
Goats | 356 | 74.7 | MAT (1:25) | Farms | Djokić et al., 2011 | |
Rats | 80 | 27.5 | MAT (1:25) | Urban | Vujanić et al., 2011 | |
Rats | 144 | 7.6 | Microscopy | |||
Mice | 12 | 3 | Microscopy | |||
Rats | 144 | 10.4 | Real-time PCR | |||
Mice | 12 | 83.3 | Real-time PCR | |||
Pigeons | 30 | 13.3 | MAT (1:25) | Urban (wild) | Personal observations | |
Bulgaria | Wild animals (7 species) | 643 | 0 – 16.7 | Agar gel micro precipitation | Wild | Arnaudov et al., 2003 |
Sheep | 380 | 48.2 | IHAT (1:10) | Farms | Prelezov et al., 2008 | |
Goats | 364 | 59.8 | IHAT (1:10) | |||
Greece (mainland) | Sheep | 840 | 53.4 | IFAT | Farms | Kontos et al., 2001 |
Sheep | 450 | 58.5 | ELISA | |||
Cattle | 105 | 20 | ELISA | Dairy farms | Diakou et al., 2005a | |
Sheep | 350 | 52.6 | ELISA | Mixed stock farms | Diakou et al., 2005b | |
Goats | 280 | 62.9 | ||||
Sheep | 184/182 | 52.2/50.5 | ELISA (a) | Organic farms | Ntafis et al., 2007 | |
Goats | 229/167 | 22.3/18 | ELISA (a) | |||
Horses/equids | 753/773 | 1.7/1.8 | ELISA (a) | Farms | Kouam et al., 2010 | |
Dogs | 2512 | 31.8 | ELISA | unknown | Haralabidis & Diakou, 1999 | |
Pigeons | 379 | 5.8 | ELISA | Domestic flocks | Diakou et al., 2011 | |
Pigeons | 50 | 0 | ELISA | Urban (wild) | ||
Σ Pigeons | 429 | 5.1 | ELISA | Σ | ||
which is consistent with reports on the rapid decrease of
The same study showed a prevalence of 85% in sheep in Serbia, of which 10% had high antibody levels of ≥1:1600, suggestive of acute infection. Although arbitrary, the cut-off of 1:1600 is even conservative since Dubey and Welcome (1988) had considered a titre of 1:1024 high. However, correlation with ovine abortions could not be established, since etiological laboratory diagnosis of ovine abortions in Serbia does not include diagnosis of
An outbreak of toxoplasmosis in sheep has recently been reported; massive abortions (60%) occurred in a flock of 500 dairy sheep in Northern Greece at 110-130 days of pregnancy, diagnosed upon observation of tissue cysts in brain smears of aborted fetuses, and by serological (ELISA) examinations of mother and fetal serum samples. The abortion rate declined immediately upon instituting sulfadimidine therapy (Giadinis et al., 2011).
In horses, who generally have lower seroprevalence values than small ruminants (van Knapen et al., 1982), a prevalence of 30.8% has been determined in a study in Serbia (Klun, 2005),
In pigs, an overall seroprevalence of 29% was established in Serbia (Klun et al., 2006). Of those seropositive, 4% were likely to be in the acute stage of infection, indicating continuous presence of infection reservoirs in the environment. Risk factors included age and farm type (Table 3). Since pigs are continuously exposed to infection, the increase in the risk of infection with age, ranging from 15% in market weight age pigs to 41% in adults, was expected, and repeated previous findings (Dubey et al., 1991; Dubey et al., 1995; Weigel et al., 1995; Damriyasa et al., 2004). Pigs on finishing type farms were four-fold more likely to be infected than those from farrow-to-finish farms. According to these results, it was proposed that a national strategy to reduce the level of
Cattle | Herd size | |||
Large (n"/>100) | 1.00 | |||
Small (n<10) | 2.19 | 1.28–3.75 | 0.004 | |
Type of housing | ||||
Stable only | 1.00 | |||
Access to outside pens | 0.37 | 0.21–0.67 | 0.001 | |
Access to pasture | 0.72 | 0.25–2.07 | 0.548 | |
Region | ||||
Northern Serbia | 1.00 | |||
Western Serbia | 2.04 | 1.10–3.79 | 0.024 | |
Central/Eastern Serbia | 0.97 | 0.32–2.90 | 0.951 | |
Belgrade District | 0.60 | 0.30–1.20 | 0.148 | |
Sheep | Farm type | |||
Private large (n"/>100) | 1.00 | |||
State-owned (n"/>100) | 4.18 | 2.18–8.00 | <0.001 | |
Private small (n<10) | 1.79 | 0.55–5.81 | 0.332 | |
Region | ||||
Northern Serbia | 1.00 | |||
Western Serbia | 4.66 | 1.18–18.32 | 0.028 | |
Central/Eastern Serbia | 0.82 | 0.25–2.73 | 0.748 | |
Pigs | Age group | |||
Market weight (<8 months) | 1.00 | |||
Adult (≥8 months) | 3.87 | 2.60–5.76 | <0.001 | |
Farm type | ||||
Farrow-to-finish | 1.00 | |||
Finishing | 3.96 | 1.97–7.94 | <0.001 | |
Risk factors for
A recent study on
On the other hand, the modern approach in farm management to provide for the welfare of the animals as well as organic food for human consumption is to develop animal-friendly (organic) farms. According to experiences from the Netherlands (Kijlstra et al., 2004), development of such farms may result in an increase in
A major reason for the control of
On the other hand, according to official statistical reports (RZS, 2006–2010), pork represents approximately 50% of all meat consumed in Serbia. Thus, although pigs were the least infected of the examined species, given the findings that the prevalence increases with age and reaches 41% in sows (Klun et al., 2006), pork consumption may significantly contribute to human infection. When used for cooking, pork is generally properly thermally processed, but in most of the SEE countries’ tradition mature pork is also highly valued for making delicatessen meat products. Raw or improperly cured sausages and ham are the source of small (family) epidemics of trichinellosis which, in spite of mandatory meat examination for
For most meat animals, although a trend is generally (worldwide) difficult to establish due to the scarcity of studies in most countries (no two time points), there is no visible reduction in the prevalence of
Ubiquitous contamination of the environment is also evident from the presence of
Existing strategies for the prevention of toxoplasmosis in countries which have been implementing them for years have led to a decrease in its incidence, but have not solved the problem of congenital infection. This clearly shows that new comprehensive strategies for the prevention of toxoplasmosis are needed. These should be based on accurate and validated data on (1) the routes and risk factors for human infection on local level, which will allow for a more efficient health education; (2) routes and risk factors for meat animal infection to diminish infection reservoirs; (3) environmental contamination. Epidemiological and epizootiological data presented in this chapter show how far along this road we have come, and more importantly, how far we still have to go to achieve successful prevention of
This work has been supported by project grant No. III 41019 from the Ministry of Education and Science of Serbia.
In the last decade, global trade increased more than twice as fast as the global GDP and growth of FDI (foreign direct investment) outpaced the growth of global exports [1, 2]. According to WDI, Global trade volume accounted for 51% of global GDP in 2000, but as in 2019, it accounts for 60% of global GDP. Global FDI stock invested by global economies in 2019 were US$34 trillion at current price, which increased at significant pace considering that it was US$7.4 trillion in 2000.
This increase in global trade accompanied by a rapid growth of FDI intrigued a number of studies to investigate the role of FDI and trade on economic growth and the relationship between the FDI and trade. Most empirical studies find complementary relationship, while few find substitute effect of FDI on trade [2, 3, 4, 5, 6]. Some studies suggest the effect of FDI on trade depends on the type of FDI, type of industry, or income level of recipient countries [3, 7, 8]. While [3] finds complementary relationship between FDI and trade in most cases, he argues the impact of FDI on import is greater than export in developing countries in short term.
Despite the effect of FDI on export can be negative (or relatively smaller than on import) for developing countries, FDI inflow enables transfer of technology and managerial skills from developed countries, hence leading to positive spillover [9]. Hence, role of FDI and trade are particularly important for emerging countries and transition countries who opened its economy quite recently.
A number of literatures classify the transition into three types: Germany, Former Soviet Union, and East-Asian types [10, 11]. This study is interested in East-Asian type in specific, covering China, Vietnam, Cambodia, and Lao PDR. These countries transformed the economic system to capitalistic market system through reform and opening up. However, they maintain their political system of one-party communist system. This type is often referred to economic transition countries.
The case of the East Asian economic transition countries is interesting as they have shown fast economic growth soon after they transited their economic system from socialist regime to market-oriented regime. China, Cambodia, Lao PDR, and Vietnam initiated economic reforms in 1979, 1989, 1986, and 1986, respectively. However, most of existing empirical studies investigate the trade determinants of specific country or countries in same geographical area or in similar development level. There is limited empirical evidence about the determinants of East Asian economic transition countries’ regional trade development.
By examining the impact of FDI on trade of these East Asian economic transition countries, this paper provides more insight into the regional and global implications of FDI and trade in East Asian economic transition countries. Policy implications can be derived for the countries that have been experiencing economic transition such as Myanmar, Cuba and the country such as North Korea in the future. Therefore, through utilizing the panel fixed effect regression, this study investigates the impact of FDI on trade.
Empirical results show complementary effect between FDI and trade when estimated using FDI flow variable. To be specific, the effect of FDI on trade is shown the highest in the order of Vietnam, China, Cambodia, and Lao PDR although the coefficient of FDI is insignificant in Cambodia. When estimated using FDI stock variable, the complementary relationship between FDI and trade weakens, and even substitutability effect is found in China at significant level. Interestingly, the coefficient of FDI is positive and significant in Vietnam in both cases.
The rest of the paper is organized as follows. In Section 2, the paper briefly investigates the role, trend and relationship between the global trade and FDI with providing a related literature review. In Section 3, terminology related to economic transition and performance of trade and FDI of East Asian economic transition countries (China, Cambodia, Laos, and Vietnam) are reviewed. In addition, FDI policies of these countries are thoroughly analyzed. In Section 4, the paper provides empirical analysis and results in Section 5. Finally, Section 6 concludes the study with a discussion of our findings.
Globalization and trade liberalization have increased integration of the world economy through financial and trade flows [12]. Global trade increased more than twice as fast as the global GDP in the last decade and growth of FDI outpaced the growth in global exports [1, 2]. Figures 1 and 2 present the global FDI and trade trends from 1970 to 2019, former expressed in current billion US$ and latter expressed in a ratio of GDP. Global trade volume accounted for 27% ($767 billion) of global GDP in 1970, 38% ($8.7 trillion) in 1990, and 51% ($15.8 trillion) in 2000. But as in 2019, it accounts for 60% ($49 trillion) of global GDP. Total global FDI net inflow was $12 billion in 1970, passing $100 billion in 1987, reaching $1.4 trillion in 2000, and $2.1 trillion in 2016.
Trends of global FDI and trade (current billion US$). Source: World Bank.
Trends of global FDI and trade (% of GDP). Source: World Bank.
The figures show that increase in global trade has been accompanied by a rapid growth of FDI. While trade gradually increases during the period both in terms of GDP or current US$, FDI shows a more volatile trend than trade with more fluctuations. Both trade and FDI fell significantly during the global financial crisis in 2008, seemed to recover, but are slowing down and decreasing in recent years. In particular, current FDI inflow ($1.6 trillion in 2019) is far below the highest record point of $3.1 trillion in 2007.
Before investigating the relationship between FDI and trade, the role of trade and FDI in economic growth is briefly explained. In general, FDI and trade development are both regarded to positively contribute to economic growth although the trends of FDI and global trade are not always correlated [3]. Theoretically, FDI is considered as an important exogenous source that enables capital accumulation of recipient countries. Inflow of FDI enables the recipient country to create new job opportunities, improve infrastructure, increase productivity, and therefore promote economic growth. Especially for developing countries, FDI inflow enables transfer of technology and managerial skills from developed countries, hence leading to positive spillover [9].
A number of studies have investigated the casual relationship between the FDI and trade flows. Figure 3 presents the trend of the relationship between global FDI inflows and global trade volume during the period 1970–2019, both expressed in current billion US$. Clearly, the fitted line shows the complementary (positive) relationship between the two with some outliers. It is interesting that the lower the values of FDI and trade, more concentrated and fitted the values are to the fitted line. Referring from Figures 1 and 2, the low values are likely to present the early periods, therefore it can be implied that the variation increased over periods thus is harder to predict the relationship as time passes.
Relationship between global FDI and trade (% of GDP). Source: World Bank.
According to [3], global trade seems to generate FDI until the mid-1980s, but after this period, this cause-and-effect relationship reversed with FDI influencing the trade significantly. In addition, [3] finds that FDI outflow increases export of originating countries, and in recipient countries, import increases in short term, and export increases in long term. Nevertheless, he addresses that although FDI inflow can increase import rather than export, recipient country can still benefit from FDI by technology transfers, job creation, local subcontracting, and etc.
Likewise, the relationship between trade and FDI can be either complementary or substitute. Dinh and Hoai [4] investigate the impact of FDI and trade openness on economic growth in 22 Asia-Pacific developing countries from 1990 to 2011 using System GMM. They find that both FDI and trade openness positively contribute to economic growth in these countries and show complementary relationship. Further, [5] examine the effect of FDI on trade in Vietnam from 1990 to 2007 utilizing a gravity model. They show that there exists a complementary relationship between FDI and trade although the impact is not significant. Cantwell and Bella (2000) argue there is a complementary relationship between FDI and trade with a growing influence of MNCs in international trade. Cantwell and Bellak [6] investigate 21 empirical studies on impact of FDI on trade in emerging countries, and conclude trade and FDI work as a complement in emerging countries.
On the other hand, utilizing system GMM estimators, [13] argue the combined effect of FDI inflow with trade openness negatively affect the economic growth, while they positively contribute when taken separately. They also address the importance of role of economic institutions on FDI and trade openness. Strengthening the argument, using gravity model, [2] also find the substitutability relationship between trade and FDI inflow in Portugal during 2000 and 2013. Interestingly, some studies suggest the effect of FDI on trade depends on the type of FDI, type of industry, or income level of recipient countries [3, 7, 8].
Global trade, a key economic indicator to examine a nation’s health, is vital for developing countries, especially for the transition countries who opened its economy relatively recently, to attract investment, enhance competitiveness, and promote economic growth. It is influenced by various factors including factor endowments (land, labor, and capital), productivity, trade costs, trade policy (barriers to trade), exchange rate, inflation, tastes, and etc. Among the determinants of trade, productivity and factor endowments gained the most attention in the trade literature [14].
To examine the impact of FDI on trade, empirical studies on determinants of trade are investigated. Goswami [15] uses panel FMOLS (Fully Modified OLS) to examine the determinants of trade development of 5 South Asian countries (India, Pakistan, Bangladesh, Sri Lanka, and Nepal) from 1980 to 2010. Trade as a ratio of GDP is utilized as the dependent variable, while per capita income, average year of schooling (proxy for human capital), bank credit to private sector (proxy for financial development), tariff rate, FDI stock, exchange rate, and infrastructure index are utilized as explanatory variables. Effect of per capita income growth, human capital, infrastructure and financial development have shown significant positive on trade of South Asian countries, while the effect of exchange rate has shown significant negative.
Dauti [16] investigates the relationship between FDI and trade in the European region based on country characteristics, classifying into two groups of ten new members of EU and five South East European countries. Gravity model is utilized with FDI stock, GDP, skill and capital endowments and trade distances. Employing various static and dynamic panel estimation models, he finds positive impact of FDI on import, and negative impact of FDI on export. The coefficients of labor and capital endowments are shown positive and significant on both export and import. Interestingly, the impact of GDP per capita on export is shown negative and significant.
In the same line, [17] examine the trade determinants of 23 transition countries in Central and Eastern Europe countries using fixed effects, random effect, IV and GMM models from 2000 to 2015. FDI, GDP, investments (gross capital formation in a ratio of GDP), trade liberalization index (TLI), exchange rate are utilized as the trade determinants. FDI, investments, and TLI have shown positive impact on trade, while exchange rate and GDP have shown no significant effect. Using the result, they suggest transition countries to promote policies to improve human resources, business environment, governance, and infrastructure to increase export.
In addition, using ARDL (Autoregressive Distributed Lag) model, [18] analyze the determinants of trade in Finland for short-run and long-run from 1990 to 2019. Without using FDI as explanatory variable, they find the impacts of inflation, urbanization and exchange rate on trade balance are negative and significant, while the impacts of unemployment and GDP on trade balance are positive and significant for both for short-run and long-run.
Moreover, recent literature includes institutional factors as major determinants of trade balance [19, 20]. Employing GMM method, [19] investigate determinants of trade of 36 Sub-Saharan Africa (SSA) countries from 1996 to 2017. Not only FDI, but also regulatory quality, rule of law, inflation, population growth and access to sea are utilized as explanatory variables. Empirical result reveals that institutional determinants and FDI and access to sea lagged by one period enhances trade openness in SSA countries during the sample periods.
Furthermore, [21] studies the impact of FDI, exchange rate and trade openness on trade balance, which is measured by subtracting volume of import from volume of export. Using sample data covering over period during 2005 and 2018 in Vietnam, he finds the impact of FDI and trade openness on trade balance is negative and significant, while the exchange rate insignificantly influences trade balance.
Including the studies mentioned in this section, most empirical studies investigate the trade determinants of specific country or countries in same geographical area or in similar development level. There is limited empirical evidence about the determinants of East Asian economic transition countries’ regional trade development.
Transition generally implies a conversion of political ∙ economic system into reformation ∙ open-door system [10]. Political system transition refers to a transformation from communism system, where only 1 party is admitted, to a democratic system, where bases on a multi-party system. Economic system transition refers to a transformation from socialism system, where every economic decision is determined by the planned economy of the central government, to a capitalistic market system, where bases on a market mechanism.
However, it is not easy to clearly distinguish which form the transitions the countries in reality are following. A number of literatures classify the transition into three types: Germany, Former Soviet Union, and East-Asian types [10, 11]. This study is interested in East-Asian type in specific, covering China, Vietnam, Cambodia, and Lao PDR. These countries transformed the economic system to capitalistic market system through reform and opening up. However, they maintain their political system of one-party communist system. This type is often referred to economic transition countries.
Going through economic transition, these countries initiated trade liberalization and market-oriented reform process in late 1980s, intensifying further in 1990
GDP trends of east Asian transition countries. Source: World Bank.
Figure 4 shows the trends of GDP per capita (in constant 2010 US$) of four East Asian economic transition countries and the data was collected from the World Bank WDI (World Development Indicators). Among four countries, China has shown the fastest growth, increasing from $720 in 1990 to $8,254 in 2019. GDP per capita of China almost doubled in the last 10 years. In case of Cambodia, GDP per capita increased from $321 in 1994 to $1,269 in 2019 with a small decrease in 2009. GDP per capita of Lao PDR increased from $462 in 1990 to $1,840 in 2019. In Vietnam, it increased from $433 in 1990 to $2,082 in 2019. Although Cambodia, Lao PDR, and Vietnam had similar starting point in early 1990s, Vietnam shows the highest improvement in GDP per capita, followed by Lao PDR and Cambodia, respectively.
Table 1 demonstrates current (2019) social and economic situations of the sample countries. Although they are all economic transition countries having same economic and political systems in common, they differ in development level, population growth, unemployment rate, and etc. First of all, except Lao PDR, rest of the countries have access to sea. In addition, Lao PDR has the highest population growth rate, following by Cambodia, Vietnam, and China, respectively. Furthermore, four countries show similar level of income inequality shown as Gini index score. Moreover, China has the highest unemployment rate of 4.6%, following by Vietnam of 2.04%, Lao PDR of 0.62%, and Cambodia of 0.13%, respectively. Last but not least, although China has the highest GDP per capita, Cambodia and Vietnam show higher GDP growth rate than China.
China | Cambodia | Lao PDR | Vietnam | |
---|---|---|---|---|
16,830 | 4,583 | 8,173 | 8,397 | |
6.11 | 7.05 | 4.65 | 7.02 | |
2.90 | 2.46 | 3.32 | 2.80 | |
4.6 | 0.13 | 0.62 | 2.04 | |
38.5 | 37.9 | 36.4 | 35.7 | |
0.46 | 1.49 | 1.55 | 0.99 | |
O | O | X | O |
Country characteristics of China, Cambodia, Lao PDR, and Vietnam.
Source: World Bank World Development Indicators (WDI).
A number of studies investigate the major contributors of economic growth in East Asian economic transition countries, and often FDI inflows and trade liberalization are suggested as the main determinants [22, 23, 24, 25, 26, 27]. Nevertheless, the relationship between FDI and trade remains one of the hottest debates as was argued in Section 2.1.
Figure 5 shows the trend of FDI net inflows in current billion US$ of China, Cambodia, Lao PDR, and Vietnam, and Figure 6 shows the trend of trade in current billion US$ of the countries during the period 1990–2019. There are two y-axis in the figure, where left axis describes the status of China, while right axis describes the rest of the countries in both figures. Also, both figures are presented in the unit of current billion US$.
Trends of FDI net inflows. Source: World Bank.
Trends of trade volume. Source: World Bank.
For the FDI net inflows presented in Figure 5, every countries show improving trends with some fluctuations. Starting economic reforms in 1978, China’s FDI inflows gradually increased from $3.49 billion in 1990 to $235.36 billion in 2018, and reaching its record high of $290.928 billion in 2013.
While China shows fall in FDI inflow in recent years, FDI inflow in Vietnam has gradually increased since the implementation of the
In the case of Cambodia, who started the reform the last in 1989, FDI inflow was $33 million in 1992, remaining stable until the early 2000s, and rapidly increased since 2004 from $131 million to $3.663 billion in 2019.
Compared to other East Asian economic transition countries, FDI inflows in Lao PDR has shown relatively slow increase in the figure. Initiating economic reforms in 1986, FDI net inflows in Lao PDR started low as -$1.62 million in 1985, rising to $159.8 million in 1996, reaching the highest in 2017 of $1,693 million, and sharply decreased in 2019 of $557.2 million.
Compared to Figure 5, trends of trade volume of East Asian economic transition countries in Figure 6 increase in stable pace with less fluctuation and small volatility. Every countries has shown significant increase in trade volume over the period although the trends of Cambodia and Lao PDR seem not improved notably relative to China or Vietnam in the figure. Trade volume of Lao PDR started at $310 million in 1990, surpassing $1 billion in 1994, reached the highest of $13 billion in 2014, and shows a decrease afterwards.
In case of Cambodia, trade volume shows a consistently increasing trend from $1.2 billion in 1993 to $33 billion in 2019. During the period, trade volume decreased only in 2009 from $13.8 billion in 2008 to $10.9 billion in 2009 attributed to the global financial crisis, but recovered afterwards by increasing its volume by $2 billion each year.
Although Lao PDR, Cambodia, and Vietnam had similar start in 1990, Vietnam shows the highest growth in trade volume from $5.26 billion in 1990 to $551 billion in 2019. Shown in the figure, it rapidly increases since 2009 similar to the case of Cambodia. Interestingly, major trading partners of Vietnam are the main foreign investors [7]. Although Vietnam shows rapid growth of trade compared to Cambodia and Lao PDR, the growth of import is faster than the export thus widening the gap between the import and export.
China’s trade volume started at $87.6 billion in the initial stage in 1990, has speed up its growth since 2000s with a decrease in 2009, 2015, 2016, and 2019. Both export and import decreased during the fluctuations, and the fluctuations are more significantly shown if demonstrated in a ratio of GDP. Interestingly, export volume accounted for 36% of GDP in 2006, but only 18.4% in 2019 although the volume increased from $991 billion in 2006 to $2,641 billion in 2019.
Trade and FDI data that were collected for Figures 5 and 6 are now presented in relationship in Figure 7 as FDI net inflows in x-axis, and trade volume in y-axis during 1990–2019. Similar to Figure 3, trade and FDI show proportional relationship for every four East Asian economic transition countries. Cambodia shows the best fit, following by Vietnam, and Lao PDR, respectively. China shows the worst fit with some significant outliers as the value of FDI increases.
Relationship between FDI and trade. Source: World Bank.
To promote economic growth, all four East Asian economic transition countries have put significant efforts to attract FDI in various ways. Countries provide various investment incentives to foreign investors, equally treat foreign and domestic investors, and established special economic zones for further engagement. In addition, apart from Lao PDR, rest of the countries have one unified central government agency responsible for promoting FDI. For foreign investors to begin investment in these countries, they should contact the administrative control tower for FDI that are summarized in Table 2.
Organization(s) | |
---|---|
| |
| |
| |
|
China first started to open up its economy by enacting the law for joint ventures in 1979 that granted a legal status for foreign investment and establishing four special economic zones (SEZs) in 1980. FDI promotion policies were modified several times and SEZ status were gradually extended to other industrial cities in 1984, 1985, 1990, and 1992 [29]. The
In Lao PDR, FDI promotion law was enacted in 1988 and was reformed several times, in 1994, 2004, 2009, and 2016 by the Investment Promotion Department (IPD) [28]. Reformation in 2009 has improved the foreign investment environment by equally treating domestic and foreign investors. Further, Special and Specific Economic Zones (SSEZ), where have independent investment procedures and provides one-stop-services for investors, was established in 2003 to attract more FDI in the country. The Ministry of Industry and Commerce (MoIC) and the Ministry of Planning and Investment (MPI) are the administrative control towers responsible for promoting FDI. Former operates administration process for general business activities, and the latter operates administration process for concession business activities and investment in SSEZ.
After devastating war in Cambodia, FDI promotion law was first initiated in 1994 to attract FDI to rehabilitate the destroyed infrastructure and enhance growth. The Council of the Development of Cambodia (CDC) plans, operates, inspects, evaluates, and also rehabilitates national investment system and projects. In 2005, the CDC established Cambodian Special Economic Zone Board (CSEZB) to plan and launch special economic zones that offer one-stop service, similar to Lao PDR’s SSEZ [32].
Vietnam started to attract FDI since enacting the Law of Foreign Investment in 1987. The law was reformed several times and was lastly revised in 2014. Export processing zones that provide special incentives were established in 1991 in accordance with the amended law of foreign investment. Anwar and Nguyen [5] argue FDI was a major factor that contributed the country transform from an agricultural based economy to an industrialized based economy. Similar to Lao PDR, MPI is responsible for promoting FDI in Vietnam, but more extensively. MPI in Vietnam not only plans, manages, and operates the national investment system, but also inspects overall investments in Vietnam. Major FDI related legislations and decrees of East Asian economic transition countries are summarized in Table 3.
Legislations and Decrees | Year of Enactment (Amendment) | |
---|---|---|
Law on Investment of the Kingdom of Cambodia | 1994 (2003) | |
Sub-decree on the Implementation of the Law on the Amendment to the Law on Investment on the Kingdom of Cambodia | 2005 | |
Sub-decree on the Organization and Functioning of the Council for the Development of Cambodia | 2005 | |
Law on Investment Promotion | 2009 | |
Decree on the Implementation of the Investment Promotion Law | 2011 | |
Law of Foreign Investment | 1987 (2014) | |
Law on Enterprises | 2005 (2014) | |
Decree on Guidelines for Some Articles of the Law on Investment | 2015 | |
Decree on Investment in the Form of Public-Private Partnership | 2015 | |
Law on Joint Ventures using Chinese and Foreign Investment | 1979 (1990) | |
Law on Enterprises Operated Exclusive with Foreign Capital | 1986 | |
The Foreign Investment Law (FIL) | 2020 |
FDI-related laws in China, Cambodia, Lao PDR, and Vietnam.
Source: author’s summary modified from [28].
The empirical analysis presented in this paper is based on a long panel data set which involves four East Asian economic transition countries over the period 1990–2019. In order to examine the effect of FDI on trade in East Asian economic transition countries (China, Cambodia, Lao PDR, and Vietnam) from 1990 to 2019, this paper utilizes OLS and panel within fixed effect model to take account of unobserved time invariant country-specific effects such as languages, trade distances, and geographical borders. Referring from reviewed literatures in Section 2.2, the general panel regression equation is as follows.
where
Hausman’s specification test was conducted to distinguish if there is a significant bias in a random effects or fixed effects. Based on the results of Hausman test, fixed effect model is consistent and favored over the random counterpart, hence, this study uses fixed effects transformation from the above equation by subtracting off the mean over time for each country so that demeaning transformation eliminates the
where
Table 4 describes the utilized variables, its source and expected signs. TRADE data is collected from WDI (World Development Indicators), and is the sum of exports and imports of goods and services. FDI data has been sourced from the UNCTAD (United Nations Conference on Trade and Development). FDI stock variable was utilized instead to FDI flows to avoid time lag and multicollinearity problems between trade and investment [3].
Variable | Definition | Expected sign | Source |
---|---|---|---|
Sum of exports and imports of goods and services (current $US) | Dependent variable | WDI | |
Inward FDI stock / FDI net inflows (current $US) | + | UNCTAD | |
GDP per capita (constant 2010 US$) | + | WDI | |
Expected years of schooling (of children) (years) | + | UNESCO | |
Real effective exchange rate (CPI based) | +/− | Brugel Datasets | |
Tariff rate, weighted mean, all products (%) | – | WDI | |
Domestic bank credit to private sector (% of GDP) | + | WDI | |
WTO accession (1 for country’s WTO accession, 0 otherwise) | + | WTO |
Variable description.
GDP, HUM, TAR, and FINA data are sourced from WDI, and EXC data are collected from the Brugel Datasets. Country’s WTO accession date is searched from the member information section of WTO website [35]. As countries have to refine its policies to comply with WTO trade principles, expected sign of WTO is positive. Further, expected impacts of FDI, GDP, HUM, and FINA on TRADE are also positive, while the expected sign of TAR is negative, and EXC can have both positive and negative impact on trade.
Table 5 presents summary statistics of collected variables for China, Cambodia, Lao PDR, and Vietnam from 1990 to 2019. Missing values of data are replaced with imputed values, where missing values between the collected values are replaced by its mean and missing values before and after the collected values are replaced by the first and last collected data.
Variable | Obs | Mean | S.D. | Min | Max |
---|---|---|---|---|---|
120 | 24.2179 | 2.6335 | 19.553 | 29.2805 | |
120 | 21.2765 | 2.8609 | 15.3087 | 26.3963 | |
120 | 9.205 | 2.8042 | 2.6064 | 14.3862 | |
120 | 6.991 | .7608 | 5.7754 | 9.0186 | |
120 | 2.2338 | .9369 | .506 | 4.003 | |
120 | 4.7187 | .1635 | 4.3531 | 5.0839 | |
120 | 2.3418 | .6133 | .5481 | 3.5016 | |
120 | 3.4407 | 1.2227 | .5197 | 5.11 | |
120 | .4583 | .5004 | 0 | 1 |
Summary statistics (1990–2019).
Before performing the estimations, F parameter test for fixed effects was conducted, which resulted in F statistic (F(3,109) = 112.25, P
Variables | (1) OLS | (2) FE | (3) China | (4) Lao PDR | (5) Vietnam | (6) Cambodia |
---|---|---|---|---|---|---|
lnFDI_flow | 0.611*** | 0.157*** | 0.197*** | 0.125*** | 0.217*** | 0.152 |
(0.0490) | (0.0365) | (0.0527) | (0.0290) | (0.0277) | (0.119) | |
lnHUM | 0.147 | 0.501*** | 0.315 | 0.345* | 0.307*** | 0.0887 |
(0.124) | (0.0898) | (0.244) | (0.189) | (0.0464) | (0.197) | |
lnGDP | 0.714*** | 0.693*** | 1.168*** | 1.281* | 2.276*** | −0.708** |
(0.155) | (0.144) | (0.270) | (0.619) | (0.216) | (0.268) | |
lnFINA | 0.286*** | 0.155** | −1.063*** | 0.276*** | −0.158 | 1.227*** |
(0.108) | (0.0601) | (0.307) | (0.0870) | (0.0953) | (0.191) | |
lnEXC | −1.394*** | 0.231 | 0.0104 | 0.280 | −0.373* | −3.346*** |
(0.383) | (0.235) | (0.331) | (0.301) | (0.186) | (0.785) | |
lnTAR | 0.0203 | −0.225** | −0.170 | 0.187 | −0.154** | 0.418 |
(0.166) | (0.102) | (0.117) | (0.196) | (0.0564) | (0.279) | |
WTO | 0.0133 | 0.0313 | 0.144 | 0.185 | −0.0936 | 0.0743 |
(0.162) | (0.107) | (0.106) | (0.136) | (0.0633) | (0.235) | |
Constant | 11.43*** | 13.81*** | 17.94*** | 7.539 | 6.524*** | 35.48*** |
(2.226) | (1.410) | (1.580) | (4.999) | (0.696) | (4.090) | |
Observations | 120 | 120 | 30 | 30 | 30 | 30 |
R-squared | 0.969 | 0.967 | 0.996 | 0.993 | 0.999 | 0.978 |
Number of countries | — | 4 | 1 | 1 | 1 | 1 |
Estimation results using FDI inflows.
Note: Standard errors in parentheses *** p < 0.01, ** p < 0.05, * p < 0.1.
Variables | (7) OLS | (8) FE | (9) China | (10) Lao PDR | (11) Vietnam | (12) Cambodia |
---|---|---|---|---|---|---|
lnFDI_stock | 0.0102 | 0.0165 | −0.278* | −0.0525 | 0.202*** | −0.114 |
(0.107) | (0.0466) | (0.155) | (0.105) | (0.0564) | (0.134) | |
lnHUM | 5.825*** | 5.251*** | 2.663*** | 8.276* | 4.124** | 13.64*** |
(1.351) | (0.770) | (0.823) | (4.792) | (1.752) | (3.843) | |
lnGDP | 0.368 | 0.731*** | 2.093*** | 1.182 | 2.676*** | 0.0875 |
(0.358) | (0.133) | (0.232) | (0.878) | (0.303) | (0.334) | |
lnFINA | 1.198*** | 0.422*** | −1.041*** | 0.206 | −0.348** | 0.544* |
(0.0962) | (0.0518) | (0.327) | (0.128) | (0.146) | (0.264) | |
lnEXC | −0.815 | 0.906*** | −0.211 | 1.949*** | −0.126 | −0.122 |
(0.606) | (0.241) | (0.338) | (0.611) | (0.316) | (0.838) | |
lnTAR | 0.151 | −0.0583 | 0.00835 | 0.258 | 0.00273 | 0.144 |
(0.233) | (0.109) | (0.137) | (0.236) | (0.107) | (0.207) | |
WTO | 0.275 | 0.128 | 0.0749 | 0.0838 | 0.121 | 0.183 |
(0.237) | (0.109) | (0.111) | (0.182) | (0.0878) | (0.174) | |
Constant | 9.927*** | 3.550* | 12.84*** | −11.43** | 0.203 | −2.854 |
(3.679) | (1.876) | (3.168) | (4.823) | (3.210) | (9.533) | |
Observations | 120 | 120 | 30 | 30 | 30 | 30 |
R-squared | 0.937 | 0.966 | 0.996 | 0.988 | 0.998 | 0.987 |
Number of countries | — | 4 | 1 | 1 | 1 | 1 |
Estimation results using FDI inward stocks.
Note: Standard errors in parentheses *** p < 0.01, ** p < 0.05, * p < 0.1.
In Table 6, the results of the OLS and fixed effect estimation for the Eq. (1) and (2) are presented utilizing FDI inflow as independent variable. Models (1) are (2) estimated regarding every four East Asian economic transition countries using OLS, and fixed effect, respectively, while Models (3), (4), (5), and (6) are estimated for each country.
Except Model (6), the impact of FDI_flow on TRADE is shown positive and significant in every model at the .01 level. For Model (1), one unit increase in FDI_flow is expected to increase TRADE by 0.611 units, holding all other variables constant. When time invariant effects are controlled in Model (2), the coefficient of FDI_flow decreases to 0.157, but stay at the .01 significance level. Among the four East Asian economic transition countries, the impact of FDI_flow on TRADE is show the highest in Vietnam, followed by China, Cambodia, and Lao PDR, respectively.
In Model (1), the sign of the coefficients of explanatory variables are shown as the study expected except for TAR. Although the coefficient of TAR is negative, it is insignificant. Also, when the time-invariant effects are controlled, the impact of TAR on TRADE is shown negative and significant in Models (2) and (5). This implies that increase in tariff rate negatively affects trade development of the country, especially in the case of Vietnam.
In addition, the coefficients of HUM are shown positive and significant in Models (2), (4) and (5) and positive but insignificant in other models. This indicates that human capital, proxied by the expected years of schooling, is important to improve trade development of the country. Interestingly, while the coefficients of GDP and FINA are shown positive and significant in most of the models, the coefficient of GDP is negative in Cambodia at the .05 level and the coefficient of FINA is negative and significant in China at the .01 level. This result suggest that GDP growth or financial development does not always promote trade in the economy.
Moreover, the coefficients of EXC are shown negative and significant in Models (1), (5), and (6), particularly high in Cambodia. This implies that increase in exchange rate deteriorates the trade of the economy in Cambodia by decreasing export volume as the price of domestic goods and services rises relatively to other foreign competitors. The impact of WTO accession is shown positive in every model except for Vietnam, but the coefficients are not significant.
Utilizing FDI stock as independent variable, the results of the OLS and fixed effect estimation are presented in Table 7. Contrary to the estimation results in Table 6, the coefficients of FDI_stock are positive but insignificant in Models (7) and (8). Even, it is shown negative and significant at .1 level in China, while it is positive at the 0.01 level in Vietnam. This result suggests that the relationship between the trade and FDI may significantly differ in empirical studies by the unit they are utilizing, and substitutability relationship could be found when FDI stock is used as explanatory variable.
In addition, the coefficients of HUM are shown positive and significant in every model, and the coefficients of GDP are also shown positive and significant in most models. Similar to Models (3) and (5) in Table 6, in Models (9) and (11), the coefficients of FINA are shown negative and significant in China and Vietnam. However, contrast to Table 6, the impact of exchange rate on trade is shown positive and significant in fixed effect model and in Lao PDR. This implies that the increase in exchange rate in Lao PDR is likely to increase imports in large amount. Last but not least, the coefficients of TAR and WTO are insignificant in every model in Table 7.
This study aims to investigate the relationship between trade and FDI in four East Asian economic transition countries, namely the China, Cambodia, Lao PDR and Vietnam. Complementary effect between FDI and trade is found when estimated using FDI flow variable. To be specific, the effect of FDI on trade is shown the highest in the order of Vietnam, China, Cambodia, and Lao PDR although the coefficient of FDI is insignificant in Cambodia. When estimated using FDI stock variable, the complementary relationship between FDI and trade weakens, and even substitutability effect is found in China at .1 significance level. Interestingly, the coefficient of FDI is positive and significant in Vietnam in both cases.
Other explanatory variables are also considered, which are human capital proxied by expected years of schooling, GDP, Domestic bank credit to private sector as a proxy for financial development, exchange rate, tariff rate, and WTO accession. Effects of GDP and human capital on trade are shown positive and significant in most cases except in Cambodia when FDI flow is utilized. Moreover, impact of financial development, tariff and exchange rate varies by model and country. Finally, the impact of WTO accession on trade is shown positive but insignificant, except for Cambodia, which shows negative coefficient when FDI stock is utilized.
These findings provide more insight into the regional and global implications of FDI and trade in East Asian economic transition countries. First, as impact of FDI on trade is shown positive, these countries should carefully promote FDI policies to maximize the benefits of FDI on trade and economic growth. Moreover, policy implications can be derived for the countries that have been experiencing economic transition such as Myanmar, Cuba and the country such as North Korea in the future.
This research was supported by the Korea University OJERI (OJEong Resilience Institute) of Korea.
The authors declare no conflict of interest.
IntechOpen implements a robust policy to minimize and deal with instances of fraud or misconduct. As part of our general commitment to transparency and openness, and in order to maintain high scientific standards, we have a well-defined editorial policy regarding Retractions and Corrections.
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\\n\\nA Correction will be issued by the Academic Editor when:
\\n\\n3.1. ERRATUM
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\\n\\n4. FINAL REMARKS
\\n\\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\\n\\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\\n\\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
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\\n\\nPolicy last updated: 2017-09-11
\\n"}]'},components:[{type:"htmlEditorComponent",content:'IntechOpen’s Retraction and Correction Policy has been developed in accordance with the Committee on Publication Ethics (COPE) publication guidelines relating to scientific misconduct and research ethics:
\n\n1. RETRACTIONS
\n\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\n\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\n\nPublishing of a Retraction Notice will adhere to the following guidelines:
\n\n1.2. REMOVALS AND CANCELLATIONS
\n\n2. STATEMENTS OF CONCERN
\n\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\n\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\n\n3. CORRECTIONS
\n\nA Correction will be issued by the Academic Editor when:
\n\n3.1. ERRATUM
\n\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\n\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n3.2. CORRIGENDUM
\n\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n4. FINAL REMARKS
\n\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\n\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\n\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\n\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
\n\nPolicy last updated: 2017-09-11
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K. Aremu",authors:[{id:"106996",title:"Dr.",name:"Shuaib",middleName:"Kayode",surname:"Aremu",slug:"shuaib-aremu",fullName:"Shuaib Aremu"}]},{id:"70727",doi:"10.5772/intechopen.90768",title:"Neuro-Olfactory Regulation and Salivary Actions: A Coordinated Event for Successful Blood-Feeding Behavior of Mosquitoes",slug:"neuro-olfactory-regulation-and-salivary-actions-a-coordinated-event-for-successful-blood-feeding-beh",totalDownloads:751,totalCrossrefCites:0,totalDimensionsCites:2,abstract:"The synergistic actions of the nongenetic and genetic factors are crucial to shape mosquitoes’ feeding behavior. Unlike males, adult female mosquitoes are evolved with unique ability to take blood meals from a vertebrate host for reproductive success which eventually makes them a potential vector. Processing and integration of chemical information in the neuro-olfactory system followed by salivary actions facilitate blood meal uptake process. Thus, deciphering the underlying molecular mechanism of odor sensing through the detection machinery (olfactory system), odor processing and decision-making by decision machinery (brain), and regulation of saliva secretion by the action machinery (salivary gland) is likely to reveal molecular pathways which can be targeted to disrupt mosquitoes’ feeding behavior. Here we summarize how smart actions of highly specialized neurosensory systems guide and manage feeding behavior associated complex events of (i) successful navigation to find a suitable host, (ii) making food choice decisions, and (iii) regulation of the salivary gland actions in mosquitoes.",book:{id:"8732",slug:"sino-nasal-and-olfactory-system-disorders",title:"Sino-Nasal and Olfactory System Disorders",fullTitle:"Sino-Nasal and Olfactory System Disorders"},signatures:"Tanwee Das De and Rajnikant Dixit",authors:[{id:"309585",title:"Dr.",name:"Tanwee",middleName:null,surname:"Das De",slug:"tanwee-das-de",fullName:"Tanwee Das De"}]}],mostDownloadedChaptersLast30Days:[{id:"70060",title:"Maxillofacial and Oral Aspects of Dysphagia",slug:"maxillofacial-and-oral-aspects-of-dysphagia",totalDownloads:971,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Oral cavity/mouth is first recipient of food. Food is broken down and prepared for initial phases of digestion. The oral preparatory phase is voluntary. In this phase, food is manipulated by the tongue and teeth. A bolus which is ready to swallow is prepared. Any disruption of oral cavity functions commonly due to oral infections, space infections, facial trauma, congenital-cleft lip and palate, temporo-mandibular joint disorders, salivary gland pathology, oral cancers, radiation therapy, etc., can cause dysphagia. In this chapter, we would explain the maxillofacial and oral aspects of dysphagia along with diagnosis and treatment aspects.",book:{id:"7844",slug:"voice-and-swallowing-disorders",title:"Voice and Swallowing Disorders",fullTitle:"Voice and Swallowing Disorders"},signatures:"Mohammed Basha",authors:null},{id:"70716",title:"Imaging in Sinonasal Disorders",slug:"imaging-in-sinonasal-disorders",totalDownloads:858,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Computed tomography (CT) is the “working horse” in sinonasal imaging and should always be the first choice. Magnetic resonance imaging (MRI) is complementary to CT when complications to rhinosinusitis or neoplasm are suspected. Imaging of the paranasal sinuses is common due to stuffy nose. In order to correct interpretation, proper imaging technique as well as knowledge of bony anatomy and variants and mucosal incidental findings are of outmost importance. Acute rhinosinusitis is very common and does not need imaging unless complications are suspected. In chronic rhinosinusitis, a CT examination is needed to find the cause and site of the mucociliary obstruction and to rule out other causes as odontogenic and fungal sinusitis and neoplasms.",book:{id:"8732",slug:"sino-nasal-and-olfactory-system-disorders",title:"Sino-Nasal and Olfactory System Disorders",fullTitle:"Sino-Nasal and Olfactory System Disorders"},signatures:"Heidi Beate Eggesbø",authors:[{id:"65505",title:"Dr.",name:"Heidi Beate",middleName:null,surname:"Eggesbø",slug:"heidi-beate-eggesbo",fullName:"Heidi Beate Eggesbø"}]},{id:"70261",title:"Sinusitis, Asthma and Headache",slug:"sinusitis-asthma-and-headache",totalDownloads:627,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Sinusitis is the infection of sinuses. Sinuses are four hollow cavities in face which are connected to nasal pathways to help moisten, warm and filter the air which we breathe in. Sinuses get irritated due to bacteria, virus and allergens. It is often associated with asthma and headache. Pressure in the sinuses is built by over production of mucous and leads to sinus headache. Asthma gets severe with the sinusitis as both are related to sino-nasal pathway. Treatment includes steroids, nasal decongestants, antibiotics and to avoid allergens which not only reduce the symptoms of asthma but also sinusitis. Acute sinusitis may turn into chronic sinusitis including narrowing of nasal passages, deviated septum and lumps in the nose (polyp). It can be treated with surgical procedures. The only way to prevent sinusitis is by precaution and medication. Post nasal drip may also associate with asthma causing bronchial constriction.",book:{id:"8732",slug:"sino-nasal-and-olfactory-system-disorders",title:"Sino-Nasal and Olfactory System Disorders",fullTitle:"Sino-Nasal and Olfactory System Disorders"},signatures:"Fozia Masood",authors:[{id:"302764",title:"Dr.",name:"Fozia",middleName:null,surname:"Masood",slug:"fozia-masood",fullName:"Fozia Masood"}]},{id:"71245",title:"Septoplasty: Endoscopic and Open Techniques",slug:"septoplasty-endoscopic-and-open-techniques",totalDownloads:955,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Septoplasty is one of the most commonly performed procedures by rhinologists. This article will provide a brief review of the surgical anatomy and the operative techniques of this procedure. Both endoscopic and open septoplasty procedures will be addressed. However, more than 15% of patients undergoing septoplasty fail to achieve symptomatic relief. Incomplete separation of the bony-cartilaginous junction and inadequate correction of the caudal septal deviation are the main reasons for persistent septal deviation after primary septoplasty. In revised septoplasty, correction of the caudal septal deviation can be done by proper correction of the cartilaginous curvature and strengthening of the structure using a batten graft.",book:{id:"8732",slug:"sino-nasal-and-olfactory-system-disorders",title:"Sino-Nasal and Olfactory System Disorders",fullTitle:"Sino-Nasal and Olfactory System Disorders"},signatures:"Yi-Tsen Lin",authors:[{id:"311313",title:"Dr.",name:"Yi-Tsen",middleName:null,surname:"Lin",slug:"yi-tsen-lin",fullName:"Yi-Tsen Lin"}]},{id:"70540",title:"Swallowing Disorders in Cervical Facial Tumors",slug:"swallowing-disorders-in-cervical-facial-tumors",totalDownloads:722,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"We review current state of the art protocols on swallowing disorders associated to cervical facial tumors. The clinician needs to translate physiology notions to bedside diagnosis. Facing such a case the ENT surgeon must follow several key steps: thorough history taking, barium transit, endoscopy evaluation of swallowing, high resolution diagnosis imaging. Afterwards surgical treatment plan should take into consideration the need to careful dissection of vascular and nervous structures. Dysphagia may present from initial diagnosis or after surgical resection of the tumor or during radiation and chemotherapy. We discuss the use of various staging scales or questionnaires for assessing quality of life. We illustrate the importance of swallowing disorders management with various cases of tumors at the level of skull base, pharynx, salivary glands, larynx, esophagus, etc. There are various solutions for dysphagia ranging from nasogastric feeding tube placement to percutaneous endoscopic gastrostomy to specially designed exercises. Sometimes the surgeon neglects these disorders and focuses on airway management. However, the rule should be to encourage swallowing as soon as possible after surgery. A good nutritional status is necessary for a positive prognosis in swallowing disorders. Team effort in tertiary oncology units is the key in supporting such complex cases.",book:{id:"7844",slug:"voice-and-swallowing-disorders",title:"Voice and Swallowing Disorders",fullTitle:"Voice and Swallowing Disorders"},signatures:"Daniela Vrinceanu and Mihai Dumitru",authors:null}],onlineFirstChaptersFilter:{topicId:"1098",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"May 11th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!1,editor:null,editorTwo:null,editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},{id:"6",title:"Viral Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",isOpenForSubmission:!0,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:null,institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:2,paginationItems:[{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"80546",title:"Streptococcal Skin and Skin-Structure Infections",doi:"10.5772/intechopen.102894",signatures:"Alwyn Rapose",slug:"streptococcal-skin-and-skin-structure-infections",totalDownloads:48,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}}]},overviewPagePublishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"6667",title:"Influenza",subtitle:"Therapeutics and Challenges",coverURL:"https://cdn.intechopen.com/books/images_new/6667.jpg",slug:"influenza-therapeutics-and-challenges",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"105e347b2d5dbbe6b593aceffa051efa",volumeInSeries:1,fullTitle:"Influenza - Therapeutics and Challenges",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. 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He obtained a Master’s degree in Public Health and PhD in Public Health and Epidemiology. He has a background in Clinical Medicine and has taken courses at higher diploma levels in public health from University of Transkei, Republic of South Africa, and African Medical and Research Foundation (AMREF) in Nairobi, Kenya. Dr. Kasenga worked in different places in and outside Malawi, and has held various positions, such as Licensed Medical Officer, HIV/AIDS Programme Officer, HIV/AIDS resource person in the International Department of Diakonhjemet College, Oslo, Norway. He also managed an Integrated HIV/AIDS Prevention programme for over 5 years. He is currently working as a Director for the Health Ministries Department of Malawi Union of the Seventh Day Adventist Church. Dr. Kasenga has published over 5 articles on HIV/AIDS issues focusing on Prevention of Mother to Child Transmission of HIV (PMTCT), including a book chapter on HIV testing counseling (currently in press). Dr. Kasenga is married to Grace and blessed with three children, a son and two daughters: Happy, Lettice and Sungani.",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}]}]},openForSubmissionBooks:{paginationCount:3,paginationItems:[{id:"11580",title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",hash:"1806716f60b9be14fc05682c4a912b41",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"March 23rd 2022",isOpenForSubmission:!0,editors:[{id:"258334",title:"Dr.",name:"Carlos Eduardo",surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11579",title:"Animal Welfare - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11579.jpg",hash:"12e4f41264cbe99028655e5463fa941a",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 1st 2022",isOpenForSubmission:!0,editors:[{id:"51520",title:"Dr.",name:"Shao-Wen",surname:"Hung",slug:"shao-wen-hung",fullName:"Shao-Wen Hung"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11578",title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",hash:"3731c009f474c6ed4293f348ca7b27ac",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 3rd 2022",isOpenForSubmission:!0,editors:[{id:"225390",title:"Dr.",name:"Asghar Ali",surname:"Kamboh",slug:"asghar-ali-kamboh",fullName:"Asghar Ali Kamboh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:2,paginationItems:[{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"80546",title:"Streptococcal Skin and Skin-Structure Infections",doi:"10.5772/intechopen.102894",signatures:"Alwyn Rapose",slug:"streptococcal-skin-and-skin-structure-infections",totalDownloads:48,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}}]},subseriesFiltersForOFChapters:[{caption:"Bacterial Infectious Diseases",value:3,count:1,group:"subseries"},{caption:"Viral Infectious Diseases",value:6,count:1,group:"subseries"}],publishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"10795",title:"Plant Stress Physiology",subtitle:"Perspectives in Agriculture",coverURL:"https://cdn.intechopen.com/books/images_new/10795.jpg",slug:"plant-stress-physiology-perspectives-in-agriculture",publishedDate:"April 28th 2022",editedByType:"Edited by",bookSignature:"Mirza Hasanuzzaman and Kamran Nahar",hash:"c5a7932b74fe612b256bf95d0709756e",volumeInSeries:11,fullTitle:"Plant Stress Physiology - Perspectives in Agriculture",editors:[{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",institutionURL:null,country:{name:"Bangladesh"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7999",title:"Free Radical Medicine and Biology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7999.jpg",slug:"free-radical-medicine-and-biology",publishedDate:"July 15th 2020",editedByType:"Edited by",bookSignature:"Kusal Das, Swastika Das, Mallanagouda Shivanagouda Biradar, Varaprasad Bobbarala and S. 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His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"217323",title:"Prof.",name:"Guang-Jer",middleName:null,surname:"Wu",slug:"guang-jer-wu",fullName:"Guang-Jer Wu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217323/images/8027_n.jpg",biography:null,institutionString:null,institution:null},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/148546/images/4640_n.jpg",biography:null,institutionString:null,institution:null},{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",biography:null,institutionString:null,institution:null},{id:"242491",title:"Prof.",name:"Angelica",middleName:null,surname:"Rueda",slug:"angelica-rueda",fullName:"Angelica Rueda",position:"Investigador Cinvestav 3B",profilePictureURL:"https://mts.intechopen.com/storage/users/242491/images/6765_n.jpg",biography:null,institutionString:null,institution:null},{id:"88631",title:"Dr.",name:"Ivan",middleName:null,surname:"Petyaev",slug:"ivan-petyaev",fullName:"Ivan Petyaev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Lycotec (United Kingdom)",country:{name:"United Kingdom"}}},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",slug:"smita-rai",fullName:"Smita Rai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",slug:"swati-sharma",fullName:"Swati Sharma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",slug:"touseef-fatima",fullName:"Touseef Fatima",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424836",title:"Dr.",name:"Orsolya",middleName:null,surname:"Borsai",slug:"orsolya-borsai",fullName:"Orsolya Borsai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",country:{name:"Romania"}}},{id:"422262",title:"Ph.D.",name:"Paola Andrea",middleName:null,surname:"Palmeros-Suárez",slug:"paola-andrea-palmeros-suarez",fullName:"Paola Andrea Palmeros-Suárez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Guadalajara",country:{name:"Mexico"}}}]}},subseries:{item:{id:"15",type:"subseries",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",slug:"azhar-rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",slug:"sergey-sedykh",fullName:"Sergey 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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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