Overview of main theories related to post-M&A HR integration.
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As M&A activities continue to rise, ‘human factors’ are often blamed for disappointing M&A outcomes. A substantial body of literature has examined various facts of the integration models and HR issues [4, 5]. In particular, HR is recognised as one of the critical factors after the M&A period (post-M&As) for success or failure outcomes [6, 7, 8, 9]. However, research in this area is more focused on emotive moments in the initiation of M&As [10], little research literature has looked at post-integration from a human resource (HR) process perspective [11].
Chinese overseas mergers and acquisitions (M&As) have a relatively short history [12], beginning with the Go Global policy in 1999 [13]. The golden age for Chinese-Western M&A deals was made between 2005 and 2017 [14], after which the Chinese government changed its policies on overseas investments, and M&A activity dropped dramatically. There was significant interest among Chinese companies to acquire the advanced technology used by Western companies [15], along with their more modern management systems [16, 17], market resources, and innovation capacity [13]. High-income countries, particularly those of North America and Europe, attracted 65.6% of Chinese foreign direct investment outflows during this period [18]. However, only a small amount of these outward-bound investments by Chinese firms has shown successful performance after the M&As. [19, 20, 21, 22].
Very few studies have examined integration during and following Chinese overseas M&As [23], and they lack a clearly defined process or an overview of content involved in this important phenomenon [24]. Further, a consistent perspective regarding the human resource integration process (HRIP) is absent as are the interaction steps. While most studies on M&As consider the human factor critical for integration [24], few scholars have considered HRIP as a dual process that is undertaken simultaneously with integration as a whole. This study focused on the Chinese -Western overseas M&As, posits that complete integration is necessary for practitioners to realise more successful merger outcomes [25]. It propose to answer the critical question: What is the HRIP and what factors should be incorporated into the HRIP after cross-border M&As?
In order to perform the investigation over post-M&A integrations, where one firm has a dominant position over the other, and simplify the interactions and process [26]. Thirty interviews were conducted using the critical incident (CI) approach [27], with representatives of 13 Western firms acquired by Chinese companies during the period from 2010 to 2016 (including the Netherlands, Germany, United Kingdom, Canada, and Australia), to understand the process. Secondary data from newspaper articles, internal HR policies, and managerial documentation were also reviewed.
This study makes two main contributions to the field of interests. The first is to analyse with preliminary information from selected companies the HR integration process through integration leadership, change and restructuring, personnel resistance, and valuable personnel retention factors. This process influences the success or failure of the M&A integration stage. The second contribution is to present a framework that can determine the success or failure factors, the actions, and some examples of HR management and behaviour during the M&A process. This study focuses entirely on Chinese overseas M&As, where a business from an Eastern culture enters a Western culture environment. Therefore, the scope is limited to predefined national characters, and does not exhaust all possible types. A discussion of the validity of the proposed framework in other contexts is also presented in this paper.
Following Pablo’s [28] definition of integration, HR integration can be defined as the post-M&A change in an organisation’s technical, administrative, and cultural configuration [11]. Many studies have addressed the causes and outcomes of HRIP, and some studies have also focussed on the integration of HR management practices [11, 25]. For instance, the failure to find consistent relationships may stem from an over-emphasis on either the pre-M&A stage (characteristic of early research in strategic management) [29], the post-M&A stage (a focus of early cultural studies) [30], and strategic management research at the expense of the interconnection between the pre- and post-M&A stages [31, 32].
The integration of organisations is the process by which two companies are combined after an M&A is announced. Often, the degree of interaction and strategy between the two companies is defined before the integration begins [33]. Therefore, the decision-making process for HR factors in the pre-M&A stage is critical in understanding the integration process [34]. Following the literary traditions on human factors in post-M&As, four central themes have been studied: leadership [33] and the integration team [35]; change [36] and the restructuring process [37]; personnel resistance [3]; and valuable personnel retention [38].
There are few systemic or structured methodological frameworks available for the study of integration itself [25]. Although several researchers have focused on a process approach [39, 40, 41, 42], this perspective has not been widely taken up as anticipated. For example, Caiazza and Volpe [43] proposed a three-staged integration process: a multi-level due diligence negotiation, an organisational culture integration, and atmospheric competences [43]. Steigenberger [38] presented an integrative framework of the general process of business integration in an M&A, which underlines the interactions between the conditions and interventions that are critical for understanding M&A outcomes. Advocates of a process approach have focused on post-acquisition management rather than examining linkages throughout the entire M&A process [39, 44]. A multidisciplinary review is needed to examine all of the critical variables that appear throughout the M&A process. While some resources are considered prerequisites for the development of a firm, such as absorptive capability [45] and integration capability [35], two critical dimensions identified by Haspeslagh and Jemison [39] are essential: the need for strategic interdependence and the need for structural autonomy [46]. Gomes and Angwin [47] summarised the critical success factors for the pre- and post-M&A phases and their inter-relationships. Furthermore, no clear linkage between the steps of the post-M&A processes and human factors has been established [48].
Most studies have investigated the human side of M&As by focusing on influential human factors within organisations [45]. These include cultural fit, the relationship between management styles, cultural tolerance, and stress-related emotions experienced by employees during and after an M&A [49, 50, 51, 52]). Other works have investigated the importance of managerial practices, such as cultural learning interventions and communication initiatives [53, 54]; openness and willingness in leadership [55]; and transparency to trust between the acquirer and the employee [56]. Although integration of human resources is important, there is a dearth of studies on HRIP practices during M&As [32, 57, 58]. Further, the current understanding of when and how human resource integration leads to cross-border acquisition success is limited and extant literature does not investigate remedies for conflicts in cross-border acquisitions.
In this study, the link between the structural, processual, and strategic dimensions of integration is also expressed through the use in the strategy literature [59, 60, 61, 62]. Integration’s strategic dimension influences its structural dimension and specifies the direction for its processual dimension. Granlund [63] also suggests that structure and action are inseparable in post-merger integration (PMI). Table 1 presents an overview of leading theories related to post-M&A HR integration taken into consideration during this study.
Stage of integration | Criteria | Human resource factors | Citation |
---|---|---|---|
Pre-integration | Define HR integration strategies | Competitive advantage resource analysis | [64, 65, 66] |
Knowledge-based resource; | |||
Resource-based view | |||
Gap analysis | [67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78] | ||
Culture fit | |||
Organisational culture assessment | |||
Cultural distance | |||
Cultural clash | |||
Work alienation | |||
Integration capabilities Internal capabilities resources (if key personnel are available) | |||
Organisational constraints (union, policies, pension, contract, and change management) | |||
Legislation in the acquired country | [79, 80, 81, 82, 83, 84] | ||
Institutional theory and institutional constraints (internal and external legitimacy, liability of foreignness, and institutional dualism) | |||
Employment system, economic organisation and control, corporate governance regimes | |||
Choose the type of methodology | Acculturation modes (interaction, assimilation, separation, and deculturation) | [85, 86] | |
Acculturation modes (infusion type, interactive amalgamation type, and independent type) | [87] | ||
Define the level of HR integration | Overall integration (procedural integration, physical integration, managerial integration, and sociocultural integration) | [88] | |
Continuum from autonomy to absorption | [89] | ||
Integration (execution) | System integration | [11, 25, 46] | |
HR management philosophy and system (acquire directly or recruit new employees; agent-type integration) | Integration of HR management practice (deletion, adoption, and maintenance of HR practices) | ||
Knowledge transfer and the learning process; | |||
Personnel integration | [11, 25, 46, 54, 87, 90] | ||
Personnel changes | |||
(Personnel assimilation mode, manager accreditation system, and changes in managerial positions) | |||
Change management | [91] | ||
Perception of decision-maker | [92] | ||
Cultural rejection | [93] | ||
Post-integration (evaluation) | Employee retention | Key personnel retention; | [92, 94, 95, 96] |
Top management turnover and career patterns | |||
Performance evaluation | Opportunistic behaviour (hold-up, shrinking, and free-riding), goal setting, and cultural retrenchment | [97, 98] |
Overview of main theories related to post-M&A HR integration.
Despite the diverse methodologies used by the studies reviewed, elements related to integration were identified in relation to the three stages of the M&A: the pre-integration stage, the integration stage, and the evaluation stage [39]. A conceptual framework for post-M&A HR integration was proposed by Chang-Howe [99], which categorises the HRIP from pre-integration (HR due diligence and determining the factors of an integration strategy) to HR integration (system integration, personnel integration, and change management) and integration outcome (success and failure indicators). It offers a clear overview of all tasks and discusses HR functions in an M&A, however, the interactional relationship between the stages remains unclear.
This study posits that a more integrative approach is required. Therefore, introducing a design management control system [97] to design a human resource intergration process (HRIP). The post-M&A HRIP can be understood as a performance management control system for the combination of two existing HR systems and two organisational cultures. This management control system incorporates a combination of competitive advantages [30] to maximise outcomes. The methodology used provides a logical workflow for organising and guiding the development of an HRIP [100]. The most important considerations for an HR management system in M&As are the level and speed of integration [41], and HRIP should be assessed with the post-merger concepts of integration strategies [50], integration planning [18], resource-based theory, and institutional theory [71, 72]. These key elements provide the content for the framework that will be used to develop the HRIP in the sections below. Previous studies on M&A integration do not differentiate between post-merger and post-acquisition integration, therefore, we employ the neutral term post-M&A integration [48].
Three primary interviews were conducted at random with specialists from Chinese M&A consulting firms and investment banking firms. Using the data from these interviews, the potential M&A cases were selected and designed in the interview questions. The samples chose from commercially oriented companies since their segmentation toward business activities would have considerable similarities. These organisations feature a diverse collection of occupations and functions that show differences in the nature of work and the social context in which it is done [101]. To keep the sample concentrated and absolute, mergers and joint ventures were excluded from the study.
Companies were selected from five Western countries, the Netherlands, Germany, United Kingdom, Canada, and Australia. The Critical Incident (CI) approach [102] was used to collect primary data on the levels and patterns of post-M&A HRIPs. The interviewee’s experience during the M&A was used to identify critical events and the processes and challenges met within the course of the M&As [103].
Contact was made with managers through professional and personal networks, and the sample was populated using a snowball approach. The sample was limited to those to whom the best access was possible and 30 interviews were conducted with representatives of 13 privately owned companies during the period from 2017 to 2020. The companies represented sectors such as manufacturing, entertainment, energy, finance, mining, and insurance. Interviews were concentrated on individuals in top management roles or who were critical to the M&A integration.
HR integration is usually quite time-consuming, ranging from three months to two years. To collect relevant information and follow the development of cases, multiple interviews were conducted with the interviewees over the period 2017–2020. Six interviewees were transferred back to China after the integration, and four of them transferred to another location. The interviews were conducted in China, the Netherlands, United Kingdom, France, and Germany. In ten cases, interviews were conducted over the telephone, and the others were through face-to-face meetings in the country where the interviewees were located.
The interview questions were drawn from the literature on PMI, using the definitions of HRIP and patterns of HRIP from Yan [11]. The interview questions were developed in greater depth to identify and illustrate processes and critical factors in PMI. The questions covered the following topics:
The general process of HRIP in the company and the parties involved.
Exceptional events that occurred during the HRIP, as recalled by the interviewee.
Emotions and personal experiences related to these events, in particular, the reasons for the emotions.
Comparison of those experiences with other aspects of the interviewee’s professional life and knowledge.
The participants were approached with carefully designed, open-ended questions. The interviews began by asking them to describe their work, responsibilities, and duties within the organisation, to examine their self-awareness in relation to their work and to confirm their rank. We then enquired about their knowledge of post-M&A management. Further, we explored the interviewees’ emotions regarding post-M&A integration and their experience in the HRIP by using backtrack questions that explored sections of time. This sample and context provided an excellent opportunity to examine key events and integration challenges in acquired Western organisations.
This study followed the grounded theory approach [104] to collect the data in stages. The primary data were gathered using semi-structured interviews. Then, by adopting content analysis, we structurally analysed the interview records to discover the specific HRIP used during the post-M&A activities. Three additional interviews were held with management consultants specialising in M&As, in the early and later stages of the research to determine whether management behaviour patterns were unique or common.
Table 2 presents the characteristics of the positions held by the participants, industry sector, interview years, and other information. The final 30 candidates were selected using the criteria of position and management experience. Interviews were performed within and outside the company and lasted approximately 1 hour on average [105]. Personal information was kept confidential, and the data were stored anonymously [106]. Although we modified the interview protocols during each interview to take advantage of emerging themes [107], each set of protocols included questions on each member’s perception of his responsibility, management experience, leadership style, the experience of the HRIP, and experience in managing conflicts and difficult emotions in the M&A process. This set of questions allowed the similarities and differences among members’ perspectives to be observed.
Interview taken year | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Deal Country | Company No. | Integration strategy | Integration result | Acquired firm industry | Deal Year | Participant No. | Job Title Acquires side | Job Title Acquired side | 2017 | 2018 | 2019 | 2020 |
1 | HR Manager of the acquired company | 1st | ||||||||||
A | Fully integrate | Failure | Heavy vehicle Manufacture | 2012 | 2 | Chairman of the Acquired company | 1st | 2nd | ||||
3 | COO of the Acquired company | 1st | ||||||||||
B | Fully integrate | Failure | Entertainment | 2015 | 4 | Head of Youth Academy | 1st | |||||
Partly integrate | Success | General manager of the Acquired company | ||||||||||
C | Energy | 2013 | 5 | 1st | ||||||||
6 | HR Director of Acquirer company | 1st | 2nd | |||||||||
7 | Director of Business Development | 1st | ||||||||||
8 | Director of Technical Department | 1st | ||||||||||
9 | Board member of the Acquirer company | 1st | ||||||||||
The Netherland | D | Fully integrate | Success | Electric product wholesale | 2005 | 10 | Director of Business development | 1st | ||||
11 | General manager of the Acquired company | 1st | ||||||||||
12 | Head of Business development | 1st | ||||||||||
E | Fully integrate | Failure | Electric product wholesale | 2011 | 13 | Operational manager | 1st | |||||
14 | HRD of the Acquired Company | 1st | 2nd | 3rd | ||||||||
F | Fully integrate | Success with re-intergration | Insurance | 2015 | 15 | CEO of the Acquired Company | 1st | |||||
16 | Secretary of the Board | 1st | 2nd | |||||||||
Chemical Manufacturer | 2016 | 17 | CFO of the Acquired Company | 1st | 2nd | 3rd | ||||||
G | Fully integrated | On going | 18 | Sales director | 1st | |||||||
Energy | 2009 | 19 | GM of the Acquired Company | 1st | ||||||||
H | Fully integrate | Success | 20 | Office manager | 1st | |||||||
I | Entertainment | 2016 | 21 | HRD of the Acquired Company | 1st | 2nd | ||||||
Germany | Fully integrate | Success with re-intergration | 22 | Director | 1st | |||||||
23 | M&A manager | 1st | ||||||||||
J | Fully integrate | Failure | Electric product | 2017 | 24 | Project manager | 1st | |||||
K | On going | Payment | 2019 | 25 | HRD of the Acquirer Company | 1st | 2nd | |||||
UK | Fully integrate | 26 | Project manager | 1st | ||||||||
Canada | L | Partly integrate | Success with re-intergration | Energy | 2012 | 27 | M&A | 1st | ||||
28 | HRD of the Acquire Company | 1st | ||||||||||
Australia | M | Success with re-intergration | Mining | 2016 | 29 | HRD of the Acquire Company | 1st | |||||
Fully integrate | 30 | HR manager of the Acquire company | 1st |
Participant sample.
Iterative analysis was performed on the qualitative data, by moving back and forth between the raw data and an emerging theoretical structure [108, 109, 110]. Three significant steps are followed in this iteration: creating provisional categories and first-order codes, integrating first-order codes and creating theoretical categories, and delimiting theory by aggregating theoretical dimensions [101].
The date employed in the qualitative research software ATLAS.ti, which facilitated the analysis of qualitative data. Interview transcripts were entered as text files into ATLAS.ti and coded. These included phrases, terms, or descriptions offered by the participants, in response to the semi-structured interviews. Open coding (initial coding) [111] was used in the first set of the coding process. Each coder began by reading the transcripts to identify the answers to the given questions, then joint statements were drawn on to form provisional categories. First-order codes and exit interviews were broken into sets of themes, using a strategy called focused coding [111] (e.g. post-M&A HRIP). This stage of analysis allowed a comparison to be made to establish differences between answers on the same topic. Measurements and extensions of critical incidents toward the change from the old to the new employer and the difference in organisational cultures and personal leadership representations were also deciphered. Once these theoretical categories were generated, we looked for the underlying dimensions to understand how different categories fit together into a coherent picture [112]. We formed different conceptual frameworks or models that described the relationship between the themes and available organisational theories. Once we identified a possible framework, we re-examined the fit or misfit of the data with a tentative theoretical understanding (e.g. [104, 108]).
Figure 1 summarises the process, using Corley and Gioia’s [10, 113] data structure, which presents first-order categories, theoretical categories, and aggregate theoretical dimensions. The aggregate theoretical dimensions shown are the ones that best explain the critical indicators that influence successful outcomes and employee emotions in HRIPs.
Overview of data structure.
The rest of the manuscript discusses the findings, followed by a discussion on the process and constraints identified in the HRIP. We also propose a general theoretical model of HRIP as well as culturally specified values and attitudes that influence successful outcomes during post-M&A integrations. This research concludes with the discussion of the implications of the model, both in theory, related to HRIP and critical factors [114].
Following the fundamental argument of Jemison and Sitkin [40], M&A should be seen as a process with distinctive characteristics, which can affect important organisational activities and outcomes [100]. The results in the qualitative phase were divided into three significant steps: pre-integration (i.e. HR due diligence, choice of HRIP, and integration strategy), integration (i.e. systems integration, personnel integration, and change management), and evaluation (i.e. designed outcome and inconsistencies). As expressed by one interviewee ‘Each company has its own story, but overall, the problems are the same. First, you need to analyse what is there and what the priority is, and then what can be done’ (Participant 13). The combination of results of the current research with existing literature led to the development of the post-acquisition HRIP framework (Figure 2), which incorporates the HR integration strategy, HR system integration, personnel integration, and change management (Table 3).
HR integration process (HRIP).
Chinese firms tend to invest overseas, in countries with higher incomes, better technology, and advanced management methods [18]. In particular, Chinese companies that pursue M&As with Western companies seek to acquire knowledge, skills, and capabilities to enhance their competitive advantage, to enter Western markets. Therefore, the level of integration can be determined, depending on the absorptive capability of the acquiring company.
The pre-integration phase, took place in three steps, based on the findings: due diligence, HR analysis derived from broader business analysis, and HRIP strategy and planning.
According to Jansen and Groot [97], the management control cycle begins as soon as a control problem occurs and continues where there is a mismatch between performance and results. This identifies the nature of the poor fit between the acquired and acquiring companies. This may be caused by several factors, such as organisational constraints, cultural distance, and institutional constraints. Factors of this type should be identified during the due diligence process, in the pre-M&A phase, for later use as terminators for the integration strategy (level of integration, integration cost, and integration phase).
During due diligence, risks that may occur in the M&A should also be identified. Once a risk is identified, methods of control should be chosen. Such methods should answer two questions: Should human resource management be integrated? and to what level should it be integrated? If integration is not necessary, an autonomy-based style of integration strategy should be chosen (i.e. preservation or holding).
The business strategy determines the HR strategy, which leads to an integration strategy. Therefore, the question of whether the company will merge or continue to operate as a separate company is determined by the overall business strategy. HR planning covers the previously identified risks from due diligence.
Once the integration strategy is determined, preparation begins. Often, the preparation will run in parallel with business negotiations and signed deals. ‘If you wait until the deal is signed off and then begin to prepare the integration, it will be too late’ (Participant 27). ‘We need to prepare the plan for the key personnel, who will stay and who need to leave, which will influence the organisational structures and later authorisations’ (Participant 14).
Communication plans will only be drawn up after the integration strategy and all other preparatory plans are fixed. ‘The preparatory plan is often aided by external consultants, but once the deal is closed, they will leave. You are, after all, left on your own to carry out the integration’ (Participant 27).
The acquisition process is so complex that managers often spend most of their time solving issues that were overlooked during the pre-M&A stage. Hence, the integration strategy and day-to-day management could be neglected. ‘HR integration begins the day after the deal is signed, and it sometimes lasts two to three years’ (Participant 27). Therefore, it is essential to offer a clear assessment of overall integration contents and steps. In this study, data were gathered on three aspects of the redefining processes utilised by acquired companies. Birkinshaw et al. [115] divided the post-acquisition process into task integration and human integration. During the integration phase, HR integration is implemented through three categories: HR system integration, personnel integration, and change management.
Systems integration concentrates on providing updated definitions for performance control and appraisal. When two existing management control systems need to be combined, or one needs to be replaced, system integration is a necessary step. System integration refers to task integration, which includes redefining organisational structures to fit the new business strategy; compliance checks of the acquirer’s internal and external requirements; and integration of two information technology (IT) systems. The findings revealed that for each M&A, the language barrier created a significant challenge between the Chinese acquirer and the acquired company. This includes language clashes in the vital areas of the IT system, internal control systems, and spoken language in the workplace. These language barriers aggravated the challenge of communication, both internally and externally. Participant 3 elaborated on this topic as:
Personnel integration includes changes to personnel in a post-M&A organisation that relates to key personnel allocation; the international transfer of key Chinese staff overseas, trilingual talent recruitment, and redundancy and reorganisation (layoffs). Control problems differ on two axes: the source of the problems may be on the individual or the organisational level, and it might manifest itself in behaviours or ideas [97]. Therefore, to promote integration, the focus should be on behaviours that are related to functional factors, namely, human resource systems and personnel allocation, as well as on ideas related to personal factors, such as emotions and cultures. ‘There is still a relationship between a boss and an employee. In fact, the transactional relationship in Western society is the same; only the Chinese understanding hides it more deeply’ (Participant 9).
The issues that most often arise from system and personnel integration revolve around the following two considerations: the organisational chart, the design of the organisation’s reporting line and the human resource needs based on the chart. ‘This analysis includes HR planning, including budgets, headcounts, layoff plans, and so on. If a layoff plan is included, a payoff plan should also be made’ (Participant 6). ‘The reorganisation of all manager positions merges between departments. If it is a complete company merge, the switch of the employment agreement should be taken into consideration’ (Participant 14).
Previous studies have devoted significant attention to the allocation of top management and the shift in organisational culture linked to the CEO’s identity, during post-M&A integration [116]. Further, studies have also focused on the impact of succession on organisational outcomes (Miller, 1993; Shen & Cannella, 2002; Zhang and Rajagopalan, 2004). This study found that the stability of new management is essential for the HRIP. Top management, including the CEO, CFO, and board of directors in acquired companies, are often replaced after the acquisition, by expatriates sent from the China-based headquarters, or recruited locally. Sometimes, due to multiple reasons (including change in organisational strategy, relocation delay, personal reasons, cultural misfit, and expectations mismatch), new management do not remain longer than one or two years. Frequent changes in top management (CEO, CFO, or critical positions within the company) creates management divisions within an organisation. Departments and stakeholders become disengaged because they lose interest in management decisions, and daily operations can progress without consulting them. Divisions between top management and operations limit the rollout of strategic decisions or new policies from the management level to the operational level. Hence, changes in strategy or new management policies are not implemented throughout the organisation. ‘Three CEOs remained within two years. Many policies were changed or were not implemented before they were changed again’ (Participant 21).
Management control produces a never-ending loop. Any unexpected incident can, and will, alter the process chosen to achieve the desired outcome. Therefore, change management is the greatest challenge in the post-M&A environment, and requires experienced and qualified human capital to manage the risk and process [117]. ‘The challenge for Chinese overseas M&A is how to develop the acquired company in the long term. The sustainability of the company is the most challenging for the Chinese owner’ (Chinese corporate owner and roundtable participant in response to the question, ‘What is the biggest challenge to managing a Chinese-owned Western company’?)
This research suggests that change management include the following elements: emotional influence, language barrier, cultural conflict, financial change, strategic change, unexpected legal constraint, and unexpected delays in the international transfer of key personnel [118].
Critical events, even if challenging, do not necessarily entail negative outcomes, as such events are recalled as disagreements over practices. Surprisingly, criticism is not usually perceived as having negative effects, but rather, as a motivating factor. The role of HR is to facilitate change and influence its direction, hence, attention should be paid to the linkages and interrelations among the three integration processes running in parallel, and their influence on each other. For instance, process redefinition in the category of systems integration, linked with international personnel transfer and reorganisation (personnel integration), will be influenced by legal constraints and the availability of expert talents in the market. This uncertainty is usually unforeseen before the integration process and, therefore, change management is both a challenge and a major part of HRIP tasks.
An important part of managing a control system is the feedback loop, controlling the designed outcome (i.e. integrated HR systems, cost efficiency, successful transfer of knowledge, combined advantage for both companies, and effective control and feedback) and influencing the failures (high cost, ineffective systems, negative emotions, loss of key personnel, lack of resources, and prolonged integration).
All control functions are linked to cost, therefore, the method of control directly influences outcomes and costs. The tighter the control, the higher the likelihood of designed outcome; however, the related cost is high. A typical profit-oriented organisation maintains a balance between functional behaviours and cost, however, maintaining control of other dysfunctional outcomes is challenging.
To achieve long-term success and ensure the continued development of the company, a few important HR management characteristics may be excluded, such as employee training, rewards, and compensation. The findings of this study have important implications for managers seeking to better manage post-M&A integration. Generally, in Chinese companies, less effort is made in training related to creativity, management skills, and culture. Moreover, mid- to long-term incentive plans are seen as weak areas for Chinese overseas human resource management. Findings from interviews and category coding show that the perceptions of critical events during integration among employees are primarily related to their emotional states. These events, even where they are challenging, do not entail negative outcomes. Conflict or difficulties due to changes caused by the acquisition should not be seen as challenges but as positive occurrences.
The challenges of integration are perceived as drivers of motivation and success. The high-performance orientation of a work team is the key driver of a successful integration outcome. Employees in the acquired company are more concerned with the opportunities for multi-cultural experiences. In particular, when action taken to solve the dilemma is justified, these employees’ discourses feature a performance orientation (even if the integration is not ultimately ideal).
Theoretical categories | Codes and interviewee numbers | |
---|---|---|
Internal capabilities and resources Organisational constraints Institutional constraints Cultural distance synergy potential The golden parachute of critical executives | To define the internal capabilities of the acquired company well and understand what available resources you have within your own company. (Nos. 15, 19, 27) The key points for HR due diligence are to determine what structures and risks the acquired company has and whether there are any compliance issues. (Nos. 27, 28, 29, 23, 17, 14) We overlooked the legal and government policies that impacted our deals. (No. 4) For Chinese companies, especially state-owned ones, government policies have a great impact on decision making. (Nos. 2, 27, 28, 15) We assess the acquired company to seek synergy potential. (Nos. 28, 24, 23, 21, 19, 15, 9) Cultural assessment and determination of cultural distance is critical during the HRDD process. (Nos. 14, 27, 21, 25, 23, 27, 29) The directors in the target company have already signed off on highly paid and well-protected exit clauses before the sale, or golden parachutes. (Nos. 27, 23) | |
Level of integration Integration cost Speed of integration | Integration can last from three months to two years. (Nos. 27, 23, 29) Determine how much effort you would like to put in and how much time you have. (Nos. 14, 21, 23, 27) How deep do you need to go and how many people need to be integrated? (Nos. 28, 29, 21, 14) | |
Run in parallel Executive replacement plan Design of the organisational structure Authorisation table design Communication plan | For HR, the work begins before the deal is made, and we run in parallel with the acquired company to prepare the transition. (Nos. 28, 25) Many plans have to be made in a limited time frame, including those for the organisational structure, the talent map, the authorisation table, and the communication plan. (Nos. 6, 14, 21, 23, 25, 27, 28) | |
Organisational structure Language barrier and communication channels Compliance/non-compliance Usability of IT systems | The organisational structure was redefined. (Nos. 21, 19, 25, 28, 29) Language (English or Chinese) often caused difficulties. (No. 7) There was no English version available in the internal system of the acquired company. No one expected that. (No. 15) The two ERP systems were just not comparable. (No. 3) I did not think compliance would be such a big issue. (No. 17) Performance control, resetting target and goals. (Nos. 21, 28) | |
Key personnel allocation International transfer (work permits) Reorganisation (layoff and recruitment) | People from the HQ were sent to the acquired company for key positions, for example: CFO, CEO, HR, and technical positions. (Nos. 2, 3, 4, 7, 8, 12, 16) Work permits are often difficult to arrange for overseas Chinese managers. (Nos. 20, 30, 16, 6). Layoffs were the number one task after the M&A, we had to let people go. (No. 28) Key positions need hiring, and we need fresh minds and talent for the new organisation. (Nos. 14,15, 21) | |
Cultural conflict Strategy change Unexpected legal & external constraints Unexpected delay of international transfer of key personnel | If one phrase is used to describe HR integration, it would be change management. (No. 28) The English of some Chinese colleagues is really not good. I cannot understand them. (No. 4) If all internal communication between Chinese colleagues is written in Chinese, we may feel left out. (Nos. 7, 12, 18, 22, 26) The decision-making process is quite one-way, and there are often significant cultural conflicts between Chinese and Western workers in relation to decision making and trust building. (Nos. 3, 1, 7, 12, 18, 22, 24, 26) The strategy of the company has changed over time. (No. 28) To survive, you will need for the company to become accustomed to the Chinese way of doing things. (No. 30) No one expected that the union would say no. (No. 4) We waited four months for the new CEO to arrive, but his visa was delayed. (No. 30) The HQ must decide whom to send over, and the key contact person changed a few times over three years. (No. 21) The person who was needed is pregnant. (No. 25) | |
Integrated HR systems Cost efficiency Successfully transfer of knowledge. Combined both companies advantage Effective control and feedback | It took us two years to integrate the two HR systems into one, it but functions pretty well now. (No. 14) The cost is much lower, and overhead costs are much more efficient. (No. 21) We set up a sharing platform and internal transfer systems for people to transfer between the China HQ and overseas locations. (Nos. 17, 11, 2, 21) Resources and talents are shared with HQ and worldwide, and we integrate the acquired company into our global scope. (Nos. 25) The internal system is linked, and the dates and results, as well as performance, can now be easily seen. (Nos. 18) We set up a clear communication and control channel to allow the employees to talk to us and get feedback, and the engagement is much higher than before. (No. 21) | |
High cost Ineffective systems Negative emotions Loss of key personnel Lack of resources Prolonged integration | Money was an issue; we needed have to wait until the Chinese manager made a decision. This is difficult sometimes for a Dutch company. (No. 4) Do we have qualified people or not? The financial manager they sent should be able to take responsibility. (No. 3) Chinese HR managers think trust issues during the HR integration process are not much of a problem. (Nos. 2, 6, 22, 29) We had three CEOs in two years. (No. 21) Almost all directors have left the company. (No. 28) Due to the current situation, we need to let the company run on its own for the time being. (No. 25) |
Coding results: Contents and processes of HR integration.
There has been a growing body of research on the variables and processes that affect the success of cross-border acquisitions. However, the critical success factors and the reasons why acquisitions integration often fail are inadequately understood [119]. According to Gunkel et al. [51], mechanisms involved during the PMI process are still unclear to scholars, and practitioners may prevent exploitation of the potential synergy that can arise from sharing or transferring resources and skills. Secondly, cross-cultural conflicts and differences between the two companies may cause problems such as stress and negative attitudes toward the acquiring company and its management, including high turnover of the acquired top executives [120].
This research responds to these calls by providing insights into the process of integrating operating synergies. It empirically investigated the human resource integration processes (HRIP) to understand the dynamics of the post-M&A phase in a cross-cultural context. The HRIP presented in this research provide a clear overview of the primary human resources that are relevant to the post-phase of a cross-border M&A. However, the interactions among the constituents of the system and the interaction between the system and its environment are complex. Thus, focusing on the critical success factors facilitating the integration of tasks and the dissemination of skills of the acquired firms, is important. This study’s intent was to develop a better understanding of the parameters that make the post M&A HR integration process successful, in the context of cross-border acquisitions, thus contributing to a better understanding of the value-added creation process and synergy realisation in international M&As.
This study contributes to international management research and provides managerial implications regarding cross-border M&As in several ways. First, a framework for HRIP is proposed. This framework will assist both managers and policymakers to understand the integration approach dominantly used in Chinese cross-border M&As and benefit from the potential synergy in the wake of Chinese cross-border M&As [121].
The proposed framework (Figure 2) incorporates three theoretical perspectives, into an integrative model and addresses post-acquisition factors and issues. It is offered as a descriptive and analytical device rather than a prescriptive model, to highlight the management of the post-acquisition integration process illuminated in this study. Secondly, the framework presented can assist consultants and executives in conducting better assessments at all stages of the M&A, including screening, planning, and negotiation. Thus, it enhance the effectiveness of interventions carried out during a post-M&A HRIP. As such, this study emphasises the role of corporate HR integration analysis as an essential and influential milestone for the exploration of the international business environment [24]. Most importantly, an approach that centres on human resource integration could drive the development of organisational integration in a positive direction. Therefore, the framework proposed in this research has implications that extend beyond the limitations of the field of HR management.
Perhaps the most straightforward implications are those derived from a logical interpretation of a researcher’s findings. ([122], p. 257) This study develops insights into the HRIP in the post-M&A period of a Chinese-acquired Western company [123]. There are both theoretical and managerial implications to the finding.
The knowledge produced should not be taken to be general, but instead specific to two sets of societies in a certain context. This knowledge is local, in that, it may be true and useful for Chinese managers who seek to work in Western environments. It is difficult to evaluate the consequences that flow from the choice of the HRIP in the relatively short history of Chinese cross-border M&As [20], Company D was more willing to cooperate during the research process than the others and we took advantage of this by interviewing more candidates within the company compared with the other companie, it may created a bias to the findings and study. However, it is valuable to monitor the further developments of these M&As and measure organisational performance over time. ‘I think our top management underestimated the challenge of HR integration and overestimated the value of human capital when the deal was made’ (Participant 21). Hence, further studies on these companies in the course of time, will be beneficial.
The evidence collected in this research supports the conclusions of recent studies, which have shown that connecting the pre- and post-M&A stages may yield improved M&A performance in general [124]. These studies report that if both strategic fit (synergy potential) and organisational fit (cultural differences and the national culture of the acquiring company) factors are known, pre-mergers can be taken into account in the choice of the post-acquisition integration approach. M&A performance is superior in deals that did not take pre-acquisition factors into account in post-acquisition decisions.
This study identifies theoretical aspects that may provide direction for future research in the field of post-M&A integration:
On the macro-level, from a strategic perspective, a focus on the interactions and interrelations between the steps during the human resource integration process (HRIP) could be fruitful.
At the micro-level, the individual process that often are barriers to synergistic integration, has been overlooked, (e.g. management divisions) and is worth further study.
It should be noted that the conceptual framework was developed through qualitative research and would require further validation with quantitative research to test the theory on a broader scale. As more cases from other industries and countries become available, it suggests using quantitative methods to test the framework.
It is the hope that the theoretical integration and review in this paper can provide a clear organising framework for future work, and that the conceptual framework proposed in this research will benefit the creation of a future focus in this field.
In recent decades, the need to increase hatchery efficacy is increasing with demand for quality chicks. Therefore, during incubation, new techniques which are associated with embryo management are increasing with this demand. A possible reason is that the newly developed broiler genotypes have diverged considerably compared to traditional genotypes in terms of the biological, physiological, and biochemical requirements [1]. Thus, manipulation of different incubation conditions to meet the requirements of modern broiler genotypes is under continuous investigation. Incubation conditions have a significant effect on hatchability, chick quality and post-hatch performance in chicken. In addition, while the first quarter of incubation is critical to chicken embryogenesis [2], the last quarter is very significant to hatch and post hatch performance [3].
Incubation temperature is the most significant incubation condition [4] and there has been an increase in studies regarding thermal manipulation (TM). TM (i.e., increasing or lowering incubation temperature) and broiler chicken embryogenesis has been deeply studied by Collin A, Tzschentke B, Piestun Y, Yahav S, and Halevy O, and the technique enhances chick quality through improved body weight gain, increased expression of genes in the breast muscle, and thermotolerance. Earlier studies laid the foundation for implementation of TM between different days of embryogenesis in addition to key factors such as duration and strength of TM to enhance the chick’s ability to cope with environmental challenges of cold and heat stress during post-hatch period [5, 6, 7, 8, 9, 10].
In an earlier study, Yahav et al. [11] reported that TM at 39.5°C for 3 hours (h)/day (d) from embryonic age (E) E11–E16 improves the chicks’ thermotolerance acquisition. A similar effect was confirmed by [12, 13, 14, 15, 16] with TM at 39.5°C for 12 h/d from E7 to E16. Recent studies have also confirmed a long-lasting effect on thermotolerance acquisition in chicks at hatch or 1-day-old chicks, for instance, Piestun et al. [17] and David et al. [18] both with TM at 39.5°C for 12 h/d from E7 to E16, Al-Zghoul et al. [19] with TM at 38.5, 39, 39.5 and 40°C for 18 h/d from E12 to E18 and Al-Zghoul et al. [20] with TM at 39°C for 18 h/d from E10 to E18.
The effect of TM on hatchability in several studies has been reported to differ extensively, with hatchability after TM being higher [11, 21, 22], reduced [9, 12, 13, 23, 24], and not affected [25, 26]. Also, studies from different researchers have shown contradicting results on chick quality parameters, and hatch or chick weight after TM exposure was increased [22, 23, 27], decreased [28], and not affected [21, 25, 29].
Production of optimal quality chicks depends on controlling incubation conditions and understanding the insights into the complex interaction among them. Although various studies have reported the benefits of TM, results are still contradicting and depend on timing, duration, and level of TM. With this background, we systematically reviewed the recent literature regarding the effect of thermal manipulation on embryonic development, hatchability, and hatching quality of broiler chicks.
The search for potentially eligible publications was conducted using electronic databases Web of science, PubMed, and Scopus. The eligibility was based on the title, abstract, and keywords, and only included articles published in English language. Filters were applied in terms of publication date (2015-01-01 to 2021-09-30 in Web of Science, PubMed, and Scopus).
The developed strings used in the literature search from three databases included: (thermal OR temperature) AND (manipulation) AND (incubation OR embryogenesis OR embryo development) AND (broiler OR chickens OR poultry).
The identified studies from each database were exported to Microsoft Excel workbook to document bibliographic information (author names, title, and publication year). The same software was used to manage and exclude duplicate studies. Thereafter, the reviewers examined the titles and abstracts, followed by examining the full version of the selected potential studies. At this point, each study was read to extract the aimed set of information. Therefore, the eligibility criteria for the final study selection included:
Animal materials are broiler chickens.
Study that entirely manipulated incubation temperatures (i.e., studies involving eggshell temperature manipulation or that combined incubation temperatures with other strategies were excluded).
Study reports TM age and a control group.
Study reports at least one of the following: hatchability, hatch rate, embryo mortality rate, body weight at hatch, body temperature at hatch, and chick quality.
The initial literature search identified a total of 229 articles (125 in Web of Science, 59 in PubMed, and 45 in Scopus database). After the elimination of 89 duplicate articles, 140 studies were available for analysis. Other 72 studies were excluded after evaluating the titles, thus a total of 68 articles were eligible for abstract screening. At this point, 30 studies were excluded because they did not meet the defined criteria, which resulted in 38 studies being available for full-text evaluation. From this, 7 studies were removed based on the previously defined criteria. Finally, 31 studies were selected and included in the definitive systematic review as shown in Figure 1.
A flowchart of the summarized study search procedure.
Table 1 summarizes the information that was extracted from the final selected studies. The studies in the systematic review were published between 2015 and 2021, and 31 papers were finally included. Intermittent TM profile (3–18 h/d) was used in most studies (24 papers, 77%) compared with continuous (24 h/d) (6 papers, 19%), and a combination of both intermittent and continuous in only one study [17], in which no depressing effect of intermittent (12 h/d) TM between E7 and E16 on embryogenesis was reported, however, continuous (24 h/d) reduced embryo weight from E16 to E21.
Reference | Control group temperature profile | TM profile | TM age/embryonic day (E) | Outcome |
---|---|---|---|---|
Piestun et al. [17] | 37.8°C | Intermittent (12 hours (h)), continuous (24 h)/day (d) at 39.5 °C | E7–E16 | There was no negative effect of intermittent TM on embryo development. Continuous TM negatively affected embryo weight, and significantly decreased the ratio of embryo weight to egg weight from E16 to E21. |
Al-Zghoul et al. [19] | 37.8°C | 39°C for 9, 12, and 18 h/d | E12–E18 | TM significantly reduced hatchability compared to control. |
Al-Zghoul et al. [30] | 37.8°C | 39°C for 9, 12, or 18 h/d | E12–E18 | 1-d-old chick body temperature was higher in 9 h TM than the other TM and control groups. |
Wilsterman et al. [26] | 37.5°C | 38.6°C | E0–E5, E5–E18 | They found no differences in hatchability and hatch weight among the groups. |
Rajkumar et al. [31] | 37.5°C | 39.5°C for 3 h/d | E16–E18 | TM did not have a significant effect on hatchability and hatch weight. |
Janisch et al. [32] | 37.8°C | High (38.8°C) and low (36.8°C) | E7–E10, E10–E13 | Low TM resulted in significant increase in hatch weight compared with high TM and the control group. |
Krischek et al. [33] | 37.8°C | High (38.8°C) and low (36.8°C) | E7 and E10, E10 and E13 | Low TM significantly decreased embryo weights (body, liver, heart) compared to high TM and control, which were similar at some level. |
Aminoroaya et al. [34] | 37.6°C | 39°C for 3 h/d | E12–E14, E15–E17 | TM did not significantly affect hatch weight and there was no significant difference among the groups in hatchability. |
Elmehdawi et al. [35] | 37.4°C | 38.4°C | E18–E20 | TM did not negatively affect hatchability, chick weight, chick length, rectal temperature, and chick quality score compared to control. |
Almeida et al. [36] | 37.5°C at 60% RH | Low (36°C), or high (39°C) at 60% RH | E13–E21 | Differences between control and high TM were not significant for incubation period but it was longer in cold TM treatment. Differences between control and low TM treatment for hatchability were not significant but it increased in high TM group. |
Al-Zghoul et al. [37] | 37.8°C | 39°C for 9, 12, and 18 h | E12–E18 | TM slightly increased embryonic body weight in comparison to control on E18. No significant difference between TM groups was observed from E12 to E16. |
Narinç et al. [38] | 37.8°C at 55% RH | 39.6 °C at 60% RH for 6 h/d | E0–E8, E10–E18 | TM significantly lowered hatchability and chick quality but lowest in late TM treatments compared with control. No statistically significant difference was observed between TM and control groups for hatch weight. |
Morita et al. [39] | 37.5°C | Low 36°C and high 39°C | E13–E21 | TM did not have a significant effect on hatch weight compared with control. Hatchability was increased in high TM but lower and similar in low TM and control treatments. |
Al-Rukibat et al. [40] | 37.8°C | 38.5°C and 40°C | 6 h at E16, 9 h at E17, and 12 h at E18 | TM did not influence hatchability. |
Zaboli et al. [41] | 37.8°C | 39.5°C for 12 h/d | E7–E16 | TM reduced hatchability by 4%, reduced hatch weight, and delayed hatch time (6 h later) compared with control. |
Al-Zghoul [42] | 37.8°C | 38.5, 39, 39.5, and 40°C for 18 h/d | E12–E18 | 1-d-old chick body temperature was higher with TM at 38.5°C than the other TM and control groups. |
Vinoth et al. [43] | 37.5°C | 40.5°C for 3 h/d | E15–E17 | TM had no significant effect on hatchability. 1-d-old chick weight did not differ between the groups. |
Al-Zghoul et al. [44] | 37.8°C | 39.5°C for 18 h/d | E10–E18 | There was no difference between the groups in hatchability, but hatch weight was significantly reduced in TM group compared with control. |
Al-Zghoul and El-Bahr [45] | 37.8°C | 38.5, 39, 39.5, and 40°C for 18 h/d at 56% RH | E12–E18 | While TM at 38.5 and 39°C did not influence the hatchability, TM 39.5 and 40°C lowered hatchability compared with control group. Similar embryonic weights were found for all the groups. |
Dalab and Ali [46] | 37.8°C | 39°C for 18 h/d | E7–E11, E11–E15, E15–E18, E7–E18 | TM significantly influenced the hatchability. Early TM significantly improved hatchability versus control. Late and long TM adversely affected hatchability and chick quality compared with control. |
David et al. [18] | 37.8°C | 39.5°C for 12 h/d | E7–E16 | Significantly decreased hatch body temperature was found in TM chickens. |
Saleh and Al-Zghoul [47] | 37.8°C | 39°C for 18 h/d | E10–E18 | TM significantly reduced hatchability but did not significantly affect body weight of 1-d-old chicks compared to control. |
Amjadian and Shahir [48] | 37.8°C | 39.5°C for 3 h/d | E11–E16 | There was no significant effect of TM on hatchability and embryonic mortality and TM did not influence chick body weight and hatch body temperature. |
Saleh et al. [49] | 37.8°C | 39°C for 18 h/d | E10–E18 | No significant difference was identified in embryonic mortality, hatchability, and hatch weight between the control and TM treatment. TM led to significantly decreased hatch body temperature. |
Tarkhan et al. [50] | 37.8°C | 39°C for 18 h/d | E10–E18 | TM significantly reduced hatchability and body temperature in 1-d-old chicks compared with control but no significant increase in weight was found in 1-d-old chicks between the groups. |
Nyuiadzi et al. [51] | 37.6°C | 37.6°C at 56%, and interruption of 15°C for 30 min at 81% RH. | E18–E19 | No significant effect of TM on hatchability was observed. At hatching, body temperature was higher in TM than in control chicks, but hatch weight was not affected by TM. |
Basaki et al. [52] | 37.5°C | Low (33°C) and high (41°C) for 3 h/d | E15–E17 | Survival rate, embryos with deformities, hatchability, and hatch weight were not significantly different between groups. |
Rocha et al. [2] | 37.5°C | Low (36°C) and high (39°C) for 6 h/d | E0–E5 | Hatch weight in low TM chicks was higher than control and high TM. |
Khaleel et al. [53] | 37.8°C | 36 and 39°C for 18 h/d | E7–E16 | TM did not significantly affect hatchability. |
Brannan et al. [54] | 37.5°C | 39.5°C for 12 h/d | E7–E16 | TM increased and decreased embryo mortality and hatchability, respectively but had no influence on hatch weight. |
Yalcin et al. [55] | 37.8°C | 38.8°C for 6 h/d | E10–E14 | TM did not affect relative embryo weight on E19 and hatchability but found strain differences in hatch weight. |
Overview of thermal manipulation studies during incubation of broiler chicken eggs.
Among the 24 intermittent TM studies, 20 articles reported the TM effect on hatchability, of which 65% found no significant effect, 30% being reduced, and a comparative study by Dalab and Ali [46] reported increased and decreased hatchability at different embryonic age. Meanwhile, embryo and/or hatch weight and chick quality were reported in 18 articles, of which 12 (67%) found no significant effect, three studies reported increased [2, 38, 50], and three reported reduced effect of TM on embryo and/or hatch weight and chick quality [42, 45, 46].
Embryo mortality was reported in four of 24 intermittent TM studies, of which three studies observed no significant difference in embryo mortality between intermittent TM and control groups [48, 49, 52]. However, Brannan et al. [54] identified increased embryo mortality in intermittent TM groups compared with control group.
Hatch or chick body temperature was reported in eight of 24 intermittent TM studies, which included no significant effect [48, 52], increased [30, 42, 51], and reduced [18, 49, 50].
From the six continuous TM studies, the application increased [39], and had no significant effect on hatchability [26, 35, 36] compared with control groups. Moreover, continuous TM increased [32], decreased [33] and had no significant effect on embryo, chick weight, or chick quality [26, 35, 39]. Furthermore, Elmehdawi et al. [35] reported no negative effect of continuous TM on hatch body temperature compared with control treatment.
In all the studies, the set standard incubation temperature was the control treatment, which was compared to TM treatments. 37.8°C was used as the standard incubation temperature in most studies (20 papers, 65%), followed by 37.5°C (8 papers, 26%). Only Aminoroaya et al. [34], Nyuiadzi et al. [51], and Elmehdawi et al. [35] used 37.6 and 37.4°C, respectively.
While most studies (23 papers, 74%) only used high-temperature TM (i.e., 1–3°C above the set standard incubation temperature), 7 papers were comparative studies of low and high-temperature TM, and only one study used low-temperature TM at 37.6°C but on 18 and 19 d of incubation, embryos were subjected to short cold exposure of 15°C for 30 minutes [51]. The above authors found no significant effect of TM from E18 to E19 on hatchability and hatch weight, but hatch body temperature was elevated compared with control group (37.6°C). In addition, studies involving low-temperature TM, the adjustments varied between 1 and 4.5°C below the set standard incubation temperature.
Three studies compared various high-temperature TM; both 38.5 and 40°C did not have any effect on hatchability [40]. Meanwhile, Al-Zghoul and El-Bahr [44] compared 38.5, 39, 39.5, and 40°C for 18 h/d from E12 to E18 and observed that 38.5 and 39°C did not impact hatchability however, 39.5 and 40°C reduced hatchability compared with control group (37.8°C). The latter TM setup was used by Al-Zghoul [42], who reported increased 1-d-old chick body temperature at 38.5°C compared with other TM and control treatments.
Three studies compared TM duration, which Al-Zghoul et al. [19] and Al-Zghoul et al. [37] identified depressed hatchability and increased embryo body weight on E18, respectively, at 39°C regardless of TM duration (9, 12, or 18 h/d) from E12 to E18. Using similar TM profile to Al-Zghoul et al. [19], Al-Zghoul et al. [37], and Al-Zghoul et al. [45] reported elevated body temperature in 1-d-old chicks at 9 h/d TM duration compared with other TM durations and control (37.8°C) treatment.
Among the seven comparative studies, low-temperature TM resulted in increased hatch weight [2, 32], reduced embryo weights [33], and both low and high-temperatures were not significantly different in hatch weight, embryo mortality, and deformed embryos [52]. Meanwhile, high-temperature TM resulted in higher hatchability [36, 39], and both low and high-temperature treatments did not impact and significantly differ in hatchability [52, 53]. Furthermore, continuous TM was used in most comparative studies [32, 33, 36, 39] compared with intermittent [2, 52, 53].
The main RH used in control and low-temperature TM studies was 56% and, 65% in high-temperature TM studies. In Table 1, we only reported RH of four studies (four papers, 14%) that used the different RH protocol from the above.
The embryonic age at the time of TM varied between E7 and E18 in most studies (24 papers, 77%), followed by E18–E20 and E0–E8 (three papers each) and one study by Morita et al. [39] reported the timing of TM from E13 to E21, which resulted in no significant influence on hatch weight but higher hatchability in high-temperature TM than low-temperature treatments.
Only seven studies compared embryo age at the timing of TM; hatchability and hatch weight were not affected by high-temperature TM at E0–E5 and E5–E18 [26], and E12–E14 and E15–E17 [34]. Also, Al-Rukibat et al. [40] showed no effect on hatchability after TM at 38.5 or 40°C for 6 h at E16, 9 h at E17 and 12 h at E18. However, TM at 39°C for 18 h/d at early embryonic age (E7–E11) significantly enhanced hatchability but in late (E11–E18) and long-term (E7–E18) negatively affected hatchability and chick quality compared with control (37.8°C) [46]. Janisch et al. [32] reported significant increase in hatch weight with low-temperature TM between (E7–E10) and (E10–E13) and Krischek et al. [33] found a significant decrease in embryo weights at low-temperature TM at E7–E10 and E10–E13 compared with high-temperature and control treatments (37.8°C). Narinç et al. [38] identified significantly depressed hatchability and chick quality in late (E10–E18) TM compared with early (E0–E8) and control (37.8°C) treatments however, all treatments were not statistically different in hatch weight.
This present review used a methodological approach to conduct a comprehensive literature search, which enabled a logical interpretation of the recent results obtained from broiler chicken incubation published studies. Thus, the effects of thermal manipulation on incubation performance, hatchability and hatching quality of broiler chicks could be examined.
The hatchery industry is expected to change dramatically with increasing demand for quality chicks and production efficacy. It is well established that incubation conditions significantly influence incubation and post-hatch performance besides, hatching quality in chickens [4]. During perinatal stage (critical period), incubation conditions may result in persistent variations in the epigenetic programming of different body systems and their roles in chickens [56]. One condition of interest is incubation temperature, which when manipulated by short or long-term may induce epigenetic adaptation thus enhancing development and maturation of particular body systems and their functions, which begins during the early periods of embryonic development [10].
TM is well known for inducing improved thermotolerance acquisition (thermoregulatory functions) in chickens, which is evidenced by reduced body temperature at hatch and during the first days post-hatch. Intermittent manipulation in incubation temperature between different embryonic ages resulted in thermoregulatory functions being boosted; 3 h of 39.5°C/d from E16 to E18 [21], 39.5°C for 12 h/d at E7–E16 [15, 16, 24], and 60 minutes exposure to 15°C at E18–E19 [57]. In our review, the similar effect was confirmed by [49, 50] at 38.5–39.5°C for 18 h/d from E10 to E18 and, David et al. [18] at 39.5°C for 18 h/d from E7 to E16. It’s clear that thermotolerance acquisition in broiler chickens can be enhanced by application of TM between E7 to E18, a period that is termed the critical stage and, the ideal embryonic age for TM.
It is scientifically proven that successful TM should be between E7 and E18, a period which enables efficient alternation in threshold stimulus of the regulatory systems during the development and maturing of the thermoregulatory mechanism (hypothalamus-hypophysis-thyroid axis) and the stress control (hypothalamus-hypophysis-adrenal axis) [9, 11, 12, 58]. It is clearly reported that thermotolerance acquisition is improved via reduced plasma triiodothyronine (T3) concentrations and basal metabolism, accompanied with lowered body temperature [15, 16, 24]. In addition, T3 is the thyroid hormone of interest in the last week of incubation because it is vital for increasing extra energy requirements during hatching [14].
However, some recent studies have reported that TM increased [30, 51] and had no influence on hatch body temperature [48, 52]. These differences may be associated with the possible elevation or similarity in hormones that regulate metabolism (T3) and growth (GH) leading to elevated or similar metabolic rate and heat production, accompanied with elevated and similar body temperature in thermal manipulated chickens and both thermal manipulated and control treatments, respectively [36, 39].
Short-term (intermittent) alteration in incubation temperature during varying age of embryogenesis can boost muscle growth and development at hatch and in the first weeks post-hatch (early period (E0–E5) [22]; mid-term (E16–E18) [59]; long-term (E12–E18 and E10–E21) [60]). In the current review, the similar effect was identified with short and long-term TM (36.8°C for 24 h/d from E7 to E13 [32]; 39°C for 9–18 h/d from E10 to E18 [37, 50]; 36.°C for 6 h/d from E10 to E5 [2]), which was indicated by increased embryo, hatch and 1-day-old chick weight. In addition, it is evidenced that TM has significant effect on proliferation and differentiation of satellite cells, and thus growth and development of embryonic and chick muscles [61].
TM at 39.5°C for 12 or 24 h/d from E7 to E16 result in accelerated myoblast proliferation and cell differentiation, which is evidenced by increased myoblast number (25–48%) in the pectoral muscle and increased expression of myogenin in embryonic muscles, respectively [17]. Similarly, Al-Zghoul et al. [37] and Al-Zghoul and El-Bahr [44] found upregulation of MyoD, myogenin, insulin-like growth factor 1 (IGF-1), and growth hormone (GH) after TM at 38.5–39°C for 9–18 h from E12 to E18 in embryos and 1-d-old chicks. Furthermore, a linear increase in embryo breast muscle weight with embryonic age was observed but significantly elevated in the TM-treated embryos compared with controls during the second quarter of embryogenesis. The interpretation of the above findings explains the possible reasons for elevated embryo, hatch and 1-day-old chick weight after TM. However, the ability of myoblasts to proliferate declined in the embryos after TM compared with embryos incubated at 37.8°C in the last quarter of incubation [17]. Furthermore, Piestun et al. [59] reported increased muscle hypertrophy in thermal manipulated embryos at 39.5°C for 3 or 6 h/d from E16 to E18. This was evidenced by upregulation of myogenin, and IGF-1 mRNA expressions in TM embryos compared with control treatment.
Studies by Zaboli et al. [41], Al-Zghoul et al. [45], and Dalab and Ali [46] reported depressed embryo, hatch, or chick weight due to intermittent high-temperature TM, which partially agrees with Piestun et al. [14]. However, Piestun et al. [14] reported that only continuous (24 h) elevation in incubation temperature (39.5°C) from E7 to E16 negatively affected embryo growth and development and hatch weight. Although the above variation could have resulted from differences in factors such as breed or strain, flock age, incubation layout, and embryo age at the time of TM, the contradicting results due to TM length may suggest a strong gap for continuous studies on the length of TM.
In the current review, TM did not influence embryo, hatch, or chick weight in 67% of the intermittent TM studies that reported the above parameter. This result has been attributed to a possible similarity in plasma T3, T4, and GH leading to similar metabolic growth rate and heat production, which result in incubation duration and chick body weight being similar in both thermal manipulated and control treatments [36, 39].
Interestingly, Janisch et al. [32] and Rocha et al. [2] observed increased hatch weight at low-temperature TM compared with high-temperatures. This result may be associated with the variations based on factors such embryo age at TM, strain, and incubation temperature profile. However, it is well established that yolk weight is a critical factor that accounts for 20% of hatch weight [62]. At low incubation temperatures, nutrient metabolic rate, and the embryo’s ability to draw liquids from the yolk sac are reduced, which result in increased yolk weights at hatch [63], and consequently, elevated hatch weight.
The effect of TM on hatchability in the present review is contradictive, with 65% of 20 studies that reported hatchability found no significant effect, 30% being reduced, and a comparative study by Dalab and Ali [46] reported increased and decreased hatchability with intermittent TM at different embryonic age. Also, earlier studies regarding TM and hatchability have shown contradicting results, for instance, Yahav et al. [11] and Piestun et al. [22] reported significantly increased hatchability with TM at 39.5°C for 3 h/d from E8 to E10 and 38.1°C for 24 h/d from E0 to E5, respectively. Yahav et al. [29] identified no effect on hatchability at 38.5°C for 3 h/d from E8 to E10. Piestun et al. [24] found decreased hatchability with TM at 39.5°C for 12 h/d from E7 to E16.
It is well documented that hatchability is depressed by overheating embryos however, length, strength, and embryo age at the time of high-temperature TM determine the effects of the application on hatchability [25]. Reduced hatchability has been associated with reduction in corticosterone concentrations at internal pipping after TM at 39°C for 2 h/d from E13 to E17 [64]. Continuous TM at 39.5°C from E7 to E16 depressed embryonic growth and development, which was accompanied by lower hatchability compared with intermittent and control treatments [14]. Low hatchability was associated with reduced development of pipping muscle (musculus complexus) on E18 and E19 day, which muscle is stated to have a significant role during hatching [14].
Meanwhile, embryo mortality rate and incubation duration or hatching time have been associated with hatchability. Brannan et al. [54], for instance, revealed increased embryonic mortalities (mid and late) after TM, which periods of development overlap with the plateau in eggshell temperature during TM at 39.5°C from E7 to E16, consequently, reduced hatchability. In addition, the above authors stated that fluctuating effect of TM on hatchability is associated with harmful levels of incubator temperature on embryo development besides, flock age, genotype, incubation design, etc. Almeida et al. [36] reported longer incubation period at low-temperature TM, which was followed by reduced hatchability compared with standard incubation and high TM.
Furthermore, reduced hatchability is linked to decreased chick quality, which is a well-known indicator for incubation challenges and investigated for assessment of incubation conditions [65]. While Elmehdawi et al. [35] identified no negative effect of high-temperature (38.4°C) TM from E18 to E20 on hatchability and chick quality, Dalab and Ali [46] observed lower hatchability and chick quality after TM at 39°C for 18/h from E15 E7 to E18. Similar to hatchability, the effect of exposure of embryos to low or high temperatures on chick quality is thought to depend on length and level of TM besides the stage of embryo development at the timing of TM [25].
Tzschentke [10] reported that slight increase in incubation temperature is expected to yield no depressing effects of TM in the last stages of embryogenesis, a period in which the development of mechanisms that regulates temperature in peripheral and central nervous systems, besides other body systems and their roles are completed. This could be the possible reason for no significant effect of TM on hatchability in most studies in the current review.
Studies by Morita et al. [39] and Amjadian and Shahir [48] identified that exposure of embryos to high temperatures increased eggshell temperature in comparison to standard incubation temperature. The eggshell temperature reflects embryo body temperature [66]. The air temperature and heat transfer between the egg and the incubator affect embryo body temperature, however, the correlation between heat production by the embryo and heat loss by the incubator determine the embryo temperature [67, 68]. It is established that the rate of chicken embryo heat production is proportional to increase in embryo development thus embryo body temperature reflects embryo development [69]. This could explain the longer incubation duration for low-temperature TM compared with control and high-treatments observed by Almeida et al. [36] and Morita et al. [39]. Earlier, Willemsen et al. [70] found significantly higher eggshell temperature (41.1°C) in high-temperature (40.6°C) compared with 35.5°C in low-temperature (34.6°C) thermal manipulated embryos, which was significantly reduced in comparison to 38.3°C of control temperature (37.6°C) from E17 to E18. Similarly, Piestun et al. [24] found that eggshell temperature was higher in thermal manipulated eggs at 39.5°C compared with standard incubation (37.8°C), accompanied by elevated hatching process of 6 h earlier. However, between E19 and E21, the eggshell temperature decreased although both the thermal treated and untreated eggs were placed in the same hatcher. Delay in hatching period has been linked to depressed metabolism in embryos after exposure to lower incubation temperatures than the standard [25].
In the current review, 65% of studies used 37.8°C as the standard incubation temperature, which also acted as the control treatment. During TM, any elevation in incubation temperature (above 37.8°C), RH is adjusted to 65% to eliminate excessive water loss from the eggs [14]. In addition, setting RH at 60% from E0 to E21 was thought to reduce the influence of RH on embryogenesis and embryonic mortality [36].
Thermal manipulation is an important approach that has been deeply studied due to its role in alleviating the effects of heat stress on broiler chickens. The success of this application depends on duration and strength of exposure in addition to embryo age at the timing of TM. The ideal embryonic stage for TM is between E7 and E18, in which thermoregulatory roles are enhanced. While intermittent TM has no adverse effects on embryonic development, hatchability, and hatching quality of broiler chicks, continuous TM depresses the above parameters. High-temperature (39–39.5°C) TM accelerates hatching time, shortens the incubation period, but has no significant effect on embryoinc development, hatchability and chick quality compared to low TM and incubation at standard temperature (37.8°C). Interestingly, in some studies, TM below 37.8°C was shown to increase chick weight at hatch compared with TM above 37.8°C. Furthermore, there is need for more comparative studies between low and high-temperature TM and the duration of TM because on addition to the available studies being insufficient, their results are also controversial. Additionally, a meta-analysis to provide an insight into contradicting results of TM application is thought of as a sound option. Also, there is need to continue studies on TM to identify the exact duration and intensity of TM and embryonic age to obtain higher hatchability and improved chick quality.
The author declares no conflict of interest.
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Al Hadithi"},{id:"16314",title:"Prof.",name:"Agustin",middleName:null,surname:"Jimenez",slug:"agustin-jimenez",fullName:"Agustin Jimenez"},{id:"16315",title:"Prof.",name:"Fernando",middleName:null,surname:"Matia",slug:"fernando-matia",fullName:"Fernando Matia"}]},{id:"13973",doi:"10.5772/13879",title:"Fuzzy Maximum Power Point Tracking Techniques Applied to a Grid-Connected Photovoltaic System",slug:"fuzzy-maximum-power-point-tracking-techniques-applied-to-a-grid-connected-photovoltaic-system",totalDownloads:3869,totalCrossrefCites:4,totalDimensionsCites:5,abstract:null,book:{id:"39",slug:"fuzzy-controllers-theory-and-applications",title:"Fuzzy Controllers",fullTitle:"Fuzzy Controllers, Theory and Applications"},signatures:"Neson Diaz, Johann Hernández and Oscar Duarte",authors:[{id:"16158",title:"BSc.",name:"Nelson",middleName:null,surname:"Diaz",slug:"nelson-diaz",fullName:"Nelson Diaz"},{id:"18354",title:"PhD.",name:"Oscar",middleName:null,surname:"Duarte",slug:"oscar-duarte",fullName:"Oscar Duarte"},{id:"18355",title:"MSc.",name:"Johann",middleName:null,surname:"Hernandez",slug:"johann-hernandez",fullName:"Johann Hernandez"}]},{id:"63709",doi:"10.5772/intechopen.80424",title:"Energy Efficient Speed Control of Interior Permanent Magnet Synchronous Motor",slug:"energy-efficient-speed-control-of-interior-permanent-magnet-synchronous-motor",totalDownloads:1244,totalCrossrefCites:5,totalDimensionsCites:5,abstract:"In this chapter, methods for the structural realization of a speed control system for the interior permanent magnet synchronous motor (IPMSM) using the “maximum torque per ampere” (MTA) and “maximum torque per volt” (MTV) optimal control strategies are considered. In the system in constant torque region, is a technique for adapting the speed controller to the presence of the reactive motor torque component, which improves the quality of the transient processes, is proposed. It is also recommended to approximate the dependence of the flux-forming current component on the motor torque by the “dead zone” nonlinearity, which will simplify the optimal control algorithm and avoid solving the fourth-degree algebraic equation in real time. For the speed control with field weakening technique, a novel system is recommended. In this system, the control algorithms are switched by the variable of the direct stator current component constraint generated in accordance with the MTA law: the upper limit is calculated in accordance with the “field weakening control” (FWC) strategy, and the lower limit in accordance with the MTV strategy. The steady-state stator voltage constraint is implemented through the variable quadrature stator current component limitation. The effectiveness of the proposed solutions is confirmed by the simulation results.",book:{id:"7485",slug:"applied-modern-control",title:"Applied Modern Control",fullTitle:"Applied Modern Control"},signatures:"Olga Tolochko",authors:[{id:"249845",title:"Dr.",name:"Tolochko",middleName:null,surname:"Olga",slug:"tolochko-olga",fullName:"Tolochko Olga"}]},{id:"62036",doi:"10.5772/intechopen.78786",title:"Development of a Genetic Fuzzy Controller and Its Application to a Noisy Inverted Double Pendulum",slug:"development-of-a-genetic-fuzzy-controller-and-its-application-to-a-noisy-inverted-double-pendulum",totalDownloads:761,totalCrossrefCites:3,totalDimensionsCites:3,abstract:"Fuzzy logic is used in a variety of applications due to its universal approximator attribute and non-linear characteristics. The tuning of the parameters of a fuzzy logic system, viz. the membership functions and the rulebase, requires a lot of trial and error. This process could be simplified by using a heuristic search algorithm like genetic algorithm (GA). In this chapter, we discuss the design of such a genetic fuzzy controller that can control an inverted double pendulum. GA improves the fuzzy logic controller (FLC) with each generation during the training process to obtain an FLC that can bring the pendulum to its inverted position. After training, the effectiveness of the FLC is tested for different scenarios by varying the initial conditions. We also show the effectiveness of the FLC even when subjected to noise and how the performance improves when the controller is tuned with noise.",book:{id:"6806",slug:"fuzzy-logic-based-in-optimization-methods-and-control-systems-and-its-applications",title:"Fuzzy Logic Based in Optimization Methods and Control Systems and Its Applications",fullTitle:"Fuzzy Logic Based in Optimization Methods and Control Systems and Its Applications"},signatures:"Anoop Sathyan and Kelly Cohen",authors:[{id:"200834",title:"Dr.",name:"Kelly",middleName:null,surname:"Cohen",slug:"kelly-cohen",fullName:"Kelly Cohen"},{id:"243285",title:"Dr.",name:"Anoop",middleName:null,surname:"Sathyan",slug:"anoop-sathyan",fullName:"Anoop Sathyan"}]}],mostDownloadedChaptersLast30Days:[{id:"75699",title:"Data Clustering for Fuzzyfier Value Derivation",slug:"data-clustering-for-fuzzyfier-value-derivation",totalDownloads:276,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The fuzzifier value m is improving significant factor for achieving the accuracy of data. Therefore, in this chapter, various clustering method is introduced with the definition of important values for clustering. To adaptively calculate the appropriate purge value of the gap type −2 fuzzy c-means, two fuzzy values m1 and m2 are provided by extracting information from individual data points using a histogram scheme. Most of the clustering in this chapter automatically obtains determination of m1 and m2 values that depended on existent repeated experiments. Also, in order to increase efficiency on deriving valid fuzzifier value, we introduce the Interval type-2 possibilistic fuzzy C-means (IT2PFCM), as one of advanced fuzzy clustering method to classify a fixed pattern. In Efficient IT2PFCM method, proper fuzzifier values for each data is obtained from an algorithm including histogram analysis and Gaussian Curve Fitting method. Using the extracted information form fuzzifier values, two modified fuzzifier value m1 and m2 are determined. These updated fuzzifier values are used to calculated the new membership values. Determining these updated values improve not only the clustering accuracy rate of the measured sensor data, but also can be used without additional procedure such as data labeling. It is also efficient at monitoring numerous sensors, managing and verifying sensor data obtained in real time such as smart cities.",book:{id:"9976",slug:"fuzzy-systems-theory-and-applications",title:"Fuzzy Systems",fullTitle:"Fuzzy Systems - Theory and Applications"},signatures:"JaeHyuk Cho",authors:[{id:"329648",title:"Prof.",name:"JaeHyuk",middleName:null,surname:"Cho",slug:"jaehyuk-cho",fullName:"JaeHyuk Cho"}]},{id:"62600",title:"Introductory Chapter: Which Membership Function is Appropriate in Fuzzy System?",slug:"introductory-chapter-which-membership-function-is-appropriate-in-fuzzy-system-",totalDownloads:1893,totalCrossrefCites:31,totalDimensionsCites:52,abstract:null,book:{id:"6806",slug:"fuzzy-logic-based-in-optimization-methods-and-control-systems-and-its-applications",title:"Fuzzy Logic Based in Optimization Methods and Control Systems and Its Applications",fullTitle:"Fuzzy Logic Based in Optimization Methods and Control Systems and Its Applications"},signatures:"Ali Sadollah",authors:[{id:"147215",title:"Dr.",name:"Ali",middleName:null,surname:"Sadollah",slug:"ali-sadollah",fullName:"Ali Sadollah"}]},{id:"63216",title:"The Design and Development of Control System for High Vacuum Deoxygenated and Water-Removal Glove Box with Cycling Cleaning and Regeneration",slug:"the-design-and-development-of-control-system-for-high-vacuum-deoxygenated-and-water-removal-glove-bo",totalDownloads:1034,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This study proposed a high vacuum deoxygenated and water removal glove box control system. Through parameter setting, the system can automatically perform various glove box cleaning operations and quickly reach the micro-oxygen and micro-water concentration requirements. In addition, two sets of reaction tanks are built in the system, and the hardware pipeline switching design and monitoring software control are used to provide two sets of reaction tanks to execute the cycling cleaning and cycling regeneration operation procedures synchronously, which can effectively solve the problem of interruption of the experimental process, improve the efficiency of its cleaning operations, and greatly reduce the manpower and material costs of the glove box operation. In addition, the system can automatically record the relevant data during various operations for the analysis of glove box monitoring effectiveness.",book:{id:"7485",slug:"applied-modern-control",title:"Applied Modern Control",fullTitle:"Applied Modern Control"},signatures:"Ming-Sen Hu",authors:[{id:"248986",title:"Associate Prof.",name:"Ming-Sen",middleName:null,surname:"Hu",slug:"ming-sen-hu",fullName:"Ming-Sen Hu"}]},{id:"63072",title:"Fuzzy Controller-Based MPPT of PV Power System",slug:"fuzzy-controller-based-mppt-of-pv-power-system",totalDownloads:1894,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The power demand has been increasing day by day due to population growth, new industrial development, etc. Meeting power demand is one of the challenge factors for fossil fuel-based power generation alone as well as the environmental issue of carbon footprint. Consequently, there is a need to concentrate on alternate energy sources to meet the power demand. In this chapter, the photovoltaic (PV) cell operation under various weather conditions is analysed, and based on the performance, the MPPT controller is developed by using fuzzy logic controller. The proposed system has been modelled in MATLAB environment, and the system performance has been analysed. Finally, the simulation results are evaluated and compared with IEEE 1547 standard for proving the effectiveness of the proposed system.",book:{id:"6806",slug:"fuzzy-logic-based-in-optimization-methods-and-control-systems-and-its-applications",title:"Fuzzy Logic Based in Optimization Methods and Control Systems and Its Applications",fullTitle:"Fuzzy Logic Based in Optimization Methods and Control Systems and Its Applications"},signatures:"M. Venkateshkumar",authors:[{id:"243101",title:"Dr.",name:"M",middleName:null,surname:"Mven",slug:"m-mven",fullName:"M Mven"}]},{id:"62654",title:"Fuzzy Information Measures with Multiple Parameters",slug:"fuzzy-information-measures-with-multiple-parameters",totalDownloads:937,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Information theory deals with the study of problems concerning any system. This includes information processing, information storage, information retrieval and decision making. Information theory studies all theoretical problems connected with the transmission of information over communication channels. This includes the study of uncertainty (information) measures and various practical and economical methods of coding information for transmission. In this chapter, the introduction of a new generalised measure of fuzzy information involving two real parameters is given. The proposed measure satisfies all the necessary properties of being a measure. Some additional properties of the proposed measure have also been studied. Further, the monotonic nature of generalised fuzzy information measure with respect to the parameters is studied and validity of the same is checked by constructing the computed tables and plots on taking different fuzzy sets and different values of the parameters. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). With consideration of all organ systems (e.g., brain, heart, lung, gut, skeletal and smooth muscle, liver, pancreas, kidney, eye) and the interactions thereof, this Physiology Series will address the goals of resolving (1) Aging physiology and chronic disease progression (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling, and (3) how changes in plasma membrane produced by lipid peroxidation products can affect aging physiology, covering new research in the area of cell, human, plant and animal physiology.",coverUrl:"https://cdn.intechopen.com/series/covers/10.jpg",latestPublicationDate:"May 14th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:49,paginationItems:[{id:"80495",title:"Iron in Cell Metabolism and Disease",doi:"10.5772/intechopen.101908",signatures:"Eeka Prabhakar",slug:"iron-in-cell-metabolism-and-disease",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:null,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81756",title:"Alteration of Cytokines Level and Oxidative Stress Parameters in COVID-19",doi:"10.5772/intechopen.104950",signatures:"Marija Petrusevska, Emilija Atanasovska, Dragica Zendelovska, Aleksandar Eftimov and Katerina Spasovska",slug:"alteration-of-cytokines-level-and-oxidative-stress-parameters-in-covid-19",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}}]},overviewPagePublishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. 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She is also the Global Harmonization Initiative (GHI) Ambassador to Sri Lanka.",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. Her research interests include microalgal biotechnology with an emphasis on microalgae-based products.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}]},{type:"book",id:"7953",title:"Bioluminescence",subtitle:"Analytical Applications and Basic Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7953.jpg",slug:"bioluminescence-analytical-applications-and-basic-biology",publishedDate:"September 25th 2019",editedByType:"Edited by",bookSignature:"Hirobumi Suzuki",hash:"3a8efa00b71abea11bf01973dc589979",volumeInSeries:4,fullTitle:"Bioluminescence - Analytical Applications and Basic Biology",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/185746/images/system/185746.png",biography:"Dr. Hirobumi Suzuki received his Ph.D. in 1997 from Tokyo Metropolitan University, Japan, where he studied firefly phylogeny and the evolution of mating systems. 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The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:null,institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda",middleName:"R.",surname:"Gharieb",fullName:"Reda Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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