Part of the book: Current Management of Malignant Melanoma
Part of the book: Recent Advances in the Biology, Therapy and Management of Melanoma
Recently, the non-coding RNAs (ncRNAs) have been classified in different categories, and its importance in regulating different cellular processes has been unravelled. The long non-coding RNAs (lncRNAs) can interact with DNA, other RNAs and proteins, including epigenetic modifiers. Some lncRNAs are related to genomic imprinting and are associated with chromatin-modifying complexes that can regulate gene transcription. It is well established that cancer cells have different epigenetic alterations and some of these modifications are associated with lncRNAs. Studies of cancer-associated lncRNAs have defined its function in the process of tumorigenesis, its impact on cell proliferation, cellular signalling, angiogenesis and metastasis. Therefore, having a better knowledge of their role might contribute to a better understanding of the diseases. In this chapter, we will discuss about lncRNA classification and functions, epigenetic marks and how they can guide transcription. Nevertheless, we will discuss how these mechanisms can interact and guide gene expression, as well as recently findings of dysregulation of lncRNAs in cancer.
Part of the book: Non-Coding RNAs