\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
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Abreu",middleName:null,surname:"Faria",fullName:"Leticia Abreu Faria",slug:"leticia-abreu-faria",email:"leticia.faria@ufra.edu.br",position:null,institution:{name:"Universidade Federal Rural da Amazônia",institutionURL:null,country:{name:"Brazil"}}},{id:"314484",title:"Mr.",name:"Elizeu Monteiro Pereira",middleName:null,surname:"Junior",fullName:"Elizeu Monteiro Pereira Junior",slug:"elizeu-monteiro-pereira-junior",email:"ta.elizeujr@gmail.com",position:null,institution:{name:"Universidade Federal Rural da Amazônia",institutionURL:null,country:{name:"Brazil"}}},{id:"314489",title:"Ms.",name:"Beatriz Martinelli",middleName:null,surname:"Lima",fullName:"Beatriz Martinelli Lima",slug:"beatriz-martinelli-lima",email:"biamartinelli13@gmail.com",position:null,institution:{name:"Universidade Federal Rural da Amazônia",institutionURL:null,country:{name:"Brazil"}}}]}},chapter:{id:"71453",slug:"advancement-of-nitrogen-fertilization-on-tropical-environmental",signatures:"Elizeu Monteiro Pereira Junior, Elaine Maria Silva Guedes Lobato, Beatriz Martineli Lima, Barbara Rodrigues Quadros, Allan Klynger da Silva Lobato, Izabelle Pereira Andrade and Letícia de Abreu Faria",dateSubmitted:"October 21st 2019",dateReviewed:"November 28th 2019",datePrePublished:"March 25th 2020",datePublished:"April 8th 2020",book:{id:"8004",title:"Nitrogen Fixation",subtitle:null,fullTitle:"Nitrogen Fixation",slug:"nitrogen-fixation",publishedDate:"April 8th 2020",bookSignature:"Everlon Cid Rigobelo and Ademar Pereira Serra",coverURL:"https://cdn.intechopen.com/books/images_new/8004.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"39553",title:"Prof.",name:"Everlon",middleName:"Cid",surname:"Rigobelo",slug:"everlon-rigobelo",fullName:"Everlon Rigobelo"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"158046",title:"Dr.",name:"Elaine Maria Silva Guedes",middleName:"Guedes",surname:"Lobato",fullName:"Elaine Maria Silva Guedes Lobato",slug:"elaine-maria-silva-guedes-lobato",email:"elaine.guedes@ufra.edu.br",position:null,institution:{name:"Universidade Federal Rural da Amazônia",institutionURL:null,country:{name:"Brazil"}}},{id:"313880",title:"Dr.",name:"Barbara",middleName:null,surname:"Rodrigues Quadros",fullName:"Barbara Rodrigues Quadros",slug:"barbara-rodrigues-quadros",email:"barbara.quadros@ufra.edu.br",position:null,institution:null},{id:"313881",title:"Dr.",name:"Izabelle",middleName:null,surname:"Pereira Andrade",fullName:"Izabelle Pereira Andrade",slug:"izabelle-pereira-andrade",email:"izabelle.andrade@ufra.edu.br",position:null,institution:null},{id:"314476",title:"Dr.",name:"Allan Klynger Da Silva",middleName:null,surname:"Lobato",fullName:"Allan Klynger Da Silva Lobato",slug:"allan-klynger-da-silva-lobato",email:"allan.lobato@ufra.edu.br",position:null,institution:{name:"Universidade Federal Rural da Amazônia",institutionURL:null,country:{name:"Brazil"}}},{id:"314477",title:"Dr.",name:"Leticia Abreu",middleName:null,surname:"Faria",fullName:"Leticia Abreu Faria",slug:"leticia-abreu-faria",email:"leticia.faria@ufra.edu.br",position:null,institution:{name:"Universidade Federal Rural da Amazônia",institutionURL:null,country:{name:"Brazil"}}},{id:"314484",title:"Mr.",name:"Elizeu Monteiro Pereira",middleName:null,surname:"Junior",fullName:"Elizeu Monteiro Pereira Junior",slug:"elizeu-monteiro-pereira-junior",email:"ta.elizeujr@gmail.com",position:null,institution:{name:"Universidade Federal Rural da Amazônia",institutionURL:null,country:{name:"Brazil"}}},{id:"314489",title:"Ms.",name:"Beatriz Martinelli",middleName:null,surname:"Lima",fullName:"Beatriz Martinelli Lima",slug:"beatriz-martinelli-lima",email:"biamartinelli13@gmail.com",position:null,institution:{name:"Universidade Federal Rural da Amazônia",institutionURL:null,country:{name:"Brazil"}}}]},book:{id:"8004",title:"Nitrogen Fixation",subtitle:null,fullTitle:"Nitrogen Fixation",slug:"nitrogen-fixation",publishedDate:"April 8th 2020",bookSignature:"Everlon Cid Rigobelo and Ademar Pereira Serra",coverURL:"https://cdn.intechopen.com/books/images_new/8004.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"39553",title:"Prof.",name:"Everlon",middleName:"Cid",surname:"Rigobelo",slug:"everlon-rigobelo",fullName:"Everlon Rigobelo"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11500",leadTitle:null,title:"Multi-Objective Optimization - Recent Advances, New Perspectives and Applications",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tThe scope of this book plans to reflect the recent advances, new perspectives, and applications utilizing multi-objective optimization techniques. It will present a comprehensive coverage platform of multi-objective optimization to supply the reader with an integrative view of the latest research. Multi-objective optimization techniques and algorithms are utilized widely in engineering, science, technology, and other fields. The proposed topics are numerous such as multi-objective optimization fundamentals and theory, multiple criteria decision-making, multi-objective programming, vector optimization, Pareto optimization, multi-objective Bayesian optimization, deep-learning optimization, nature and bio-inspired optimization, non-deterministic polynomial-time (NP)-complex, real-world search and optimization problems, multi-objective optimization applications, and case studies, advanced topics and future research, multi-objective optimization in machine learning, high-order and derivative-free optimization methods, machine learning algorithm, predictive modeling, multi-objective evolutionary, and artificial intelligence optimization techniques, conventional aggregation approaches, genetic algorithms (GAs), evolution strategies (ESs), differential evolution (DE), estimation of distribution algorithms (EDAs), multi-objective particle swarm optimization, multi-objective genetic algorithm, multi-objective GreyWolf optimization, and other recent nature-inspired algorithms. The proposed book will be useful for undergraduates, graduate students, researchers, professors, and field engineers. It aims to combine both theoretical coverage and real-world application concepts. It will provide sufficient and valuable knowledge of various multi-objective optimization techniques from traditional to recent advances. The book will not be limited to the mentioned topics only, but the authors have complete liberty to submit chapters from their current work related to optimization methods.
",isbn:"978-1-83768-147-1",printIsbn:"978-1-83768-146-4",pdfIsbn:"978-1-83768-148-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"842f84f308439c0a55c4e8e6a8fd9c01",bookSignature:"Dr. Adel El-Shahat",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11500.jpg",keywords:"Fundamentals and Theory, Multi-Objective Programming, Vector Optimization, Multicriteria Optimization, Pareto Optimization, Multi-Objective Bayesian Optimization, Deep-Learning Optimization, Machine Learning Algorithm, Evolutionary Algorithmic Frameworks, Genetic Algorithms, Evolution Strategies, Differential Evolution",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 24th 2022",dateEndSecondStepPublish:"July 28th 2022",dateEndThirdStepPublish:"September 26th 2022",dateEndFourthStepPublish:"December 15th 2022",dateEndFifthStepPublish:"February 13th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"17 days",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Adel El-Shahat is an Assistant Professor - Energy Program, School of Engineering Technology at Purdue University, USA. Dr. El-Shahat is the founder and director of Advanced Power Units and Renewable Distributed Energy Lab (A_PURDUE) for modeling, design, optimization, and control, and a member of the American Association for the Advancement of Science and the American Society for Engineering Education.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"193331",title:"Dr.",name:"Adel",middleName:null,surname:"El-Shahat",slug:"adel-el-shahat",fullName:"Adel El-Shahat",profilePictureURL:"https://mts.intechopen.com/storage/users/193331/images/system/193331.jpg",biography:"Dr. Adel El-Shahat received a B.Sc. in Electrical Engineering from Zagazig University, Egypt, in 1999. the M.Sc. in Electrical Engineering (Power and Machines) from Zagazig University, Egypt, in 2004, and the Ph.D. degree (Joint Supervision) from Zagazig University, Egypt, and The Ohio State University (OSU), Columbus, OH, USA, in 2011. He is currently an Assistant Professor - Energy Technology, School of Engineering Technology at Purdue University, USA. He is the Founder and Director of Advanced Power Units and Renewable Distributed Energy Lab (A_PURDUE). His research focuses on Modeling, Design, Multi-Objectives Optimization, Simulation, Analysis, and Control of various aspects such as Smart Nano & Micro- Grids; Electric Mobility & Transportation Electrification, Renewable Energy Systems; Wireless Charging of Electric Vehicles; Electric Vehicles; Special Purposes Electric Machines; Deep Learning Techniques; Distributed Generation Systems; Thermoelectric Generation; Special Power Electronics Converters; Power Systems; Energy Storage & Conservation; and Engineering Education. So far, He has 9 books, 5 chapters in books, 63 journal papers, 73 conference papers, and 106 other publications with his collaborators, and students related to his research interests. He has more than 20 years of working experience in academia and industry. He has experience in funding grant proposals, and He got some awards and recognitions due to his research work. He has good experience directing research for both graduate and undergraduate students for funded projects. He holds full-time academic positions at Purdue University, Georgia Southern University, the University of Illinois at Chicago, Ohio State University, USA, and Suez University, Egypt, along with some full-time and part-time positions in Egyptian companies as an electrical engineer, and consultant as a professional engineer. Additionally, He has distinguished professional training, and He is a Senior Member in the IEEE and IRED institutions along with 21 professional memberships in other societies. Finally, He served as a book editor for 4 books, and a reviewer for 8 books. He is a guest editor and editor-in-chief for three international journals. Also, He is a reviewer for other 35 international journals. Moreover, He served as invited conference sessions chair and reviewer for 31 international conferences along with other community and academic services.",institutionString:"Purdue University West Lafayette",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"Purdue University West Lafayette",institutionURL:null,country:{name:"United States of America"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"15",title:"Mathematics",slug:"mathematics"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"347258",firstName:"Marica",lastName:"Novakovic",middleName:null,title:"Ms.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"marica@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"6187",title:"Advanced Applications for Artificial Neural Networks",subtitle:null,isOpenForSubmission:!1,hash:"c7fb38ad3b189551aa9a91eaa3da04d1",slug:"advanced-applications-for-artificial-neural-networks",bookSignature:"Adel El-Shahat",coverURL:"https://cdn.intechopen.com/books/images_new/6187.jpg",editedByType:"Edited by",editors:[{id:"193331",title:"Dr.",name:"Adel",surname:"El-Shahat",slug:"adel-el-shahat",fullName:"Adel El-Shahat"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5703",title:"Electrical Resistivity and Conductivity",subtitle:null,isOpenForSubmission:!1,hash:"1610778635f74a85054885a032a5554a",slug:"electrical-resistivity-and-conductivity",bookSignature:"Adel El Shahat",coverURL:"https://cdn.intechopen.com/books/images_new/5703.jpg",editedByType:"Edited by",editors:[{id:"193331",title:"Dr.",name:"Adel",surname:"El-Shahat",slug:"adel-el-shahat",fullName:"Adel El-Shahat"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7211",title:"Electric Machines for Smart Grids Applications",subtitle:"Design, Simulation and Control",isOpenForSubmission:!1,hash:"6704a769e34bd70d714b589a67565018",slug:"electric-machines-for-smart-grids-applications-design-simulation-and-control",bookSignature:"Adel El-Shahat",coverURL:"https://cdn.intechopen.com/books/images_new/7211.jpg",editedByType:"Edited by",editors:[{id:"193331",title:"Dr.",name:"Adel",surname:"El-Shahat",slug:"adel-el-shahat",fullName:"Adel El-Shahat"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9290",title:"Applied Electromechanical Devices and Machines for Electric Mobility Solutions",subtitle:null,isOpenForSubmission:!1,hash:"2e50c2d9cf3922f5f8fff01aaef1053e",slug:"applied-electromechanical-devices-and-machines-for-electric-mobility-solutions",bookSignature:"Adel El-Shahat and Mircea Ruba",coverURL:"https://cdn.intechopen.com/books/images_new/9290.jpg",editedByType:"Edited by",editors:[{id:"193331",title:"Dr.",name:"Adel",surname:"El-Shahat",slug:"adel-el-shahat",fullName:"Adel El-Shahat"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"19449",title:"Mechanics of Cold Rolling of Thin Strip",doi:"10.5772/23344",slug:"mechanics-of-cold-rolling-of-thin-strip",body:'Cold rolled thin strip has a wide application in electronic and instrument industries, and its production has always been of major interest to the manufacturers and researchers in the area of metal plasticity. Thin strip rolling involves significant metal plasticity to produce a desired product. Iwamoto (2004), Stoughton & Yoon (2004) and Huh et al. (2004) were interested in dealing with the plastic deformation and plastic yielding of steel, and its micro-mechanics. With the need for higher quality and productivity in cold strip mill, mathematical models of cold rolling of a strip with a desired shape and dimension, both for mill set-up and for on-line control, have become a key issue in the steel rolling process. One major part of these models concerns the strip and roll deformation, plastically deformed strip shape and profile. The development of the roll deformation model can be divided into three groups, which includes simple beam model, slit beam model and finite element analysis model (Ginzburg, 1989). Stone & Gray (1965) modelled the roll deformation as the deflection of a simple beam on an elastic foundation. Shohet & Townsend (1968) proposed a slit beam deflection model, and then Edwards & Spooner (1973), Wang (1986) improved this theory and introduced a matrix method to solve the beam deflection considering strip plastic deformation. It has now been widely used in analysis of the roll deformation and strip shape and profile. Timoshenko & Goodier (1970), Jiang et al. (2003a, b, c), Komori (1998) and Lin & Lee (1997) used finite element model and numerical methods to analyse the strip rolling and to improve the simulation accuracy of the strip shape and profile. In order to improve the quality of the produced products, Kim & Oh (2003) used finite element method to analyse grain-by-grain deformation by crystal plasticity with couple stress, Simth et al. (2003) conducted a study of the effect of the transverse normal stress on sheet metal formability and Ho et al. (2004) developed integrated numerical techniques to predict springback in creep forming thick aluminum sheet components. Buchheit et al. (2005) performed simulations of realistic looking 3-D polycrystalline microstructures generated. The simulation on precipitate induced hardening in crystal plasticity was conducted (Han et al., 2004). Martin & Smith (2005) investigated the influence of the compressive through-thickness normal stress on sheet metal formability and tried to explore the ways to improve the sheet metal formability. However, the finite element analysis is rather complicated and may have a convergence problem, which is difficult to be used for on-line control of the thin strip rolling. An influence function method analysis considering the strip plastic deformation and roll deformation can be directly used in the control of strip rolling, especially in the control of the shape and profile of strip.
In practical rolling of thin strip, there is a phenomenon that the upper and lower work rolls may contact each other beyond the edges of strip if the strip is very thin and there is no work roll bending applied as shown in Fig. 1.
In this chapter, a modified semi-infinite body model was introduced to calculate the flattening of work roll/backup roll, work roll/strip, and the Foppl model (Ginzburg & Azzam, 1997) was employed to simulate the edge contact between the upper and down work rolls. Based on the theory of the slit beam, this special cold rolling of thin strip was calculated using an influence function method. The rolling force determined from the plasticity of metal forming was iterated in the simulation, and the analysis of the mechanics of the rolls is for dealing with the plasticity of this special rolling through factors such as the rolling force and torque, and the strip plastic deformation such as the strip shape and profile. A comparison of the forces and the strip shape with or without the work roll edge contact was carried out. The effects of the different rolling parameters, such as the reduction, strip width, friction coefficient and transverse friction distribution, on the mechanics and deformation of the cold rolling of thin strip were analyzed. The developed model is useful in improving the shape and flatness quality of thin strip in cold rolling process. Based on the developed method and research results, a comprehensive model which is suitable for considering the work roll edge contact or not can be obtained.
Edge contact of work rolls and Slit beam deflection mode for a 4-high rolling mill
As symmetry of the mill about the mid-span of the rolls, the calculation process involves one half of a roll system. Given in Fig. 1, one half of the roll barrel and the strip are divided into
As shown in Fig. 2, if
where
where the influence function,
Deformation of the roll from an arbitrary load distribution
The deflection of the work rolls due to bending and shear forces can be described as the vertical displacement of the work roll at element
where
The exact forms of the influence functions
where
The deformation of the backup roll can be expressed as the vertical displacement of the backup roll at the
where
where
As shown in Fig. 3, the infinite plane
where
Semi-infinite body model
Flattening between the work roll and strip
Given in Fig. 4, the projected arc of contact between the work roll and strip,
where
where
where
Fig. 5 shows the flattening between the backup roll and work roll. It can also be found from Foppl model (Ginzburg & Azzam, 1997) that the flattening contact width between the backup roll and work roll is far less than the diameters of the work roll and backup roll, and it is suitable to calculate the flattening according to a semi infinite body model (Wang, 1986).
Flattening between the backup roll and work roll
Assuming the contact pressure between the backup roll and work roll,
Distribution of contact pressure along the contact width
where
where
The work roll contacts at the edges outside the strip width are considered here as a new analysis of the cold rolling of thin strip. As shown in Fig. 7, the contact length between the upper and down work rolls due to strip plastic deformation,
where
Flattening between the upper and down work rolls
Under a rolling load, the deformation of the work roll, backup roll and the strip are described in Fig 8. Compatibility for the contact of the work roll and backup roll varies with the sum of the contour of the deformed work roll and backup roll, and the local flattening of the rolls. It can be calculated by the relationship
where
The contour of the work roll surface in contact with the strip is determined by the combined influence of the rolling load, machined and thermal crown and the local flattening between the work roll and strip. The exit thickness of the strip at any point is the same as the loaded gap height at that point. Thus, the compatibility for contact of the work roll and strip can be expressed as
where
Compatibility for contact of the work roll and backup roll, the work roll and strip, the upper and down work rolls
In the rolling of thin strip, the sides of work rolls beyond the strip width may touch and deform. The edge contacts between the upper and down work rolls affect the deformation of the roll and the strip. The compatibility for edge contact of the upper and down work rolls is calculated from the deformed work roll profile and the centreline value of the flattening between the work roll and strip, which is written as Eq. (20).
Static equilibrium of the work roll is obtained by summing vertically the load between the work roll and backup roll, the load between the work roll and strip, the load between the upper and down work rolls, and the load applied to the work roll by the work roll bending mechanism. It can be expressed as Eq. (21).
The iterative method was used to calculate the roll and strip deformation and the strip shape, as shown in Fig. 9.
The parameters used in the simulation for cold rolling of thin strip are as follows.
Work roll diameter: 63 mm | Work roll barrel: 249 mm |
Work roll crown: 0 | Poisson’s ratio of work roll: 0.3 |
Young’s modulus of work roll: 22000 Kg/mm2 | Distance between housing screw: 340 mm |
Backup roll diameter: 228 mm | Backup roll barrel: 249 mm |
Backup roll crown: 0 | Poisson’s ratio of backup roll: 0.3 |
Young’s modulus of backup roll: 22000 Kg/mm2 | Slab thickness of strip: 0.5 mm |
Central distance between bending cylinder: 340 mm | Entry thickness of strip: 0.30 mm |
Exit thickness of strip: 0.10 mm | Width of strip: 140 mm |
Back tension: 0 kN | Front tension: 0 kN |
Rolling speed: 1 m/s | Initial crown of strip at entry: 0.0 mm |
Friction coefficient: 0.1 | Work roll bending force: 0 kN/chock |
Defining point of strip crown from edge: 10 mm |
Flow chart of the roll and strip deformation and strip shape calculation
Deformation resistance equation for strip is written as Eq. (22).
The slab thickness is 0.5 mm and the exit thickness of strip is 0.12 mm. The front and back tension is zero. The effects of the different rolling parameters such as the reduction, strip width, friction coefficient and the friction distribution along the strip width, on the mechanics and deformation of the cold rolling of thin strip are analyzed when an influence of edge contact force of the work rolls is considered. In the calculation, a significant concern is the rolling force, which is determined from the plasticity of the metal forming. The calculated rolling force is employed first, and then the further iterations are carried out.
For carbon steel rolling, the rolling force is calculated by using Bland-Ford-Hill model (Wang, 1983) considering the strip plastic deformation.
where
where
where
where
where
where H and h are the entry and exit thickness of strip, respectively, C
where is the reduction and f the friction coefficient.
When the entry and exit thickness of strip is 0.2 mm and 0.12 mm respectively, friction coefficient 0.1, strip width 160 mm and the work roll bending force is zero. The calculated results such as the exit thickness distribution of strip along the strip width and the specific force distribution between the work roll and backup roll, between the upper and down work rolls, between the work roll and strip along the roll barrel with or without edge contact of the work rolls are shown in Fig. 10 and Table 2. It can be seen that the intermediate force closer to the edge of the roll barrel increases and the rolling force close to the side of the strip reduces due to the work roll edge contact. The maximum edge contact force at the edge of the roll barrel is larger than the backup work roll intermediate force, which will result in further wear of work rolls at this zone. The edge contact force between the upper and down work rolls is nearly 11 % of the rolling force. Due to the effect of the edge contact force of the work rolls, the crown of the strip reduces from 45.56 to 36.54 m, and the edge contact of the work rolls can improve the strip shape when there is no work roll bending force applied. When the cold thin strip is rolled, the edge contact effect may occur and its effect must be introduced for calculating the roll and strip deformation, strip shape, thus forming a new analysis feature of the rolling process.
Status | Rolling force (kN) | Intermediate force (kN) | Edge contact force (kN) | Crown of exit strip ( | Edge contact length (mm) |
Edge contact | 595.99 | 661.29 | 65.30 | 36.54 | 36.0 |
No edge contact | 620.25 | 620.25 | 0 | 45.56 | 0 |
Comparison of specific forces and strip crown with or without edge contact effect
Comparison of specific forces and exit thickness distribution with or without edge contact effect
When the exit thickness of strip is 0.12 mm, friction coefficient 0.1, strip width 160 mm and no work roll bending force is applied, the entry thickness of the strip are 0.15, 0.17 and 0.2 mm respectively. The effect of the reduction on the specific forces (rolling force, intermediate force and edge contact force) and the exit thickness distribution is shown in Fig. 11 and Table 3. It can be seen that with increasing entry thickness of strip, the rolling force and intermediate force increase significantly, and at the same time the edge contact force and edge contact length of the work rolls have a tendency to increase, which are caused by an increase of reduction. It can also be seen that the strip profile (strip crown) reduces significantly when the reduction decreases (see Table 3). In the simulation, it is found that when the entry thickness is less than 0.1425 mm, which indicates that the reduction is less than 15.8 %, the upper and down work rolls do not touch and the edge contact force is zero. Therefore, under a certain exit thickness of strip, the strip shape and profile become poor with an increase of the reduction although there is a tendency of an increase of the edge contact forces.
Effect of entry thickness on specific force and exit thickness distribution
Entry thickness (mm) | Rolling force (kN) | Intermediate force (kN) | Crown of exit strip ( | Edge contact force (kN) | Edge contact length (mm) |
0.15 | 401.30 | 408.09 | 23.62 | 6.79 | 13.0 |
0.17 | 504.11 | 536.81 | 29.67 | 32.69 | 27.0 |
0.20 | 595.99 | 661.29 | 36.54 | 65.30 | 36.0 |
Comparison of specific forces and strip profiles for different entry thickness
The effect of the strip widths on the work roll edge contact force is more complex. In the calculation, the strip entry and exit thickness are 0.17 mm and 0.12 mm respectively, the friction coefficient is 0.1 and the work roll bending force is zero. The strip widths of 80, 100, 120, 140, 160 and 180 mm were introduced in the analysis. The effect of the strip widths on the exit strip thickness distribution is shown in Fig. 12. It can be seen that with a narrower strip, the strip shape and profile are improved and the rolling force, intermediate force and edge contact force also reduce significantly (see Table 4). If the strip width is larger and more close to the edge of the rolls, the deflection of the work roll increases by a combined effect of the change of the distribution of the rolling force and intermediate force when the strip widths vary (see Fig. 13a and b), so the edge contact force and contact length of the work rolls increase accordingly, as shown in Fig. 13c. If the strip widths are less than 100 mm, the deflection of the work roll at the edge and the edge contact force will reduce with a narrower strip. It can be concluded that the strip width has a significant influence on the edge contact force and edge contact length of work rolls, which can result in an unstable work roll edge wear.
The lubrication and friction of the strip is a key issue in cold rolling process. The values of the friction coefficient may change significantly in different cold rolling mills and different operating conditions. The effects of the different friction coefficients on the edge contact of the work rolls are shown in Table 5 and Fig. 14. The entry and exit thickness of strip are 0.17 and 0.12 mm respectively, the strip width is 160 mm, and no work roll bending force is applied. With an increase of friction coefficient, the rolling force, intermediate force and edge contact force of the work rolls increase significantly. On the other hand, the strip shape reduces to 25.91 m from 31.61 m when the friction coefficient increases from 0.07 to 0.13. Although a higher rolling force has a tendency to make the strip shape poorer, the increase of edge contact forces with friction coefficient has a major effect on the improvement of the strip profile. Therefore, when the friction coefficient increases, the edge contact force of the work rolls increases, which is helpful in improving the strip profile.
The friction coefficient along the strip width is not a constant due to the change along the strip width of operating parameters, i.e. the rolling force, reduction and rolling speed etc.
Effect of the strip widths on the distribution of exit strip thickness
Effect of the strip widths on the roll deflection and flattening (a), specific forces (b) and edge contact forces (c)
However, there are no reports on the effect of the friction variation along the strip width due to the complexity of this problem. In this section, the entry thickness of strip is 0.30 mm, exit thickness of strip 0.10 mm, strip width 140 mm, back tension 0 kN, front tension 0 kN, metal flow resistance is described by Eq. (22), and no work roll bending force is applied, and the different transverse friction coefficients were assumed to be constant f, parabolic increasing fi and parabolic decreasing fd along the strip width as shown in Fig. 15.
Width of strip (mm) | Rolling force (kN) | Intermediate Force (kN) | Crown of exit strip ( | Edge contact force (kN) | Edge contact length (mm) |
80 | 235.39 | 264.05 | 14.48 | 28.66 | 33.0 |
100 | 300.27 | 337.74 | 18.78 | 37.48 | 35.0 |
120 | 367.83 | 411.52 | 23.05 | 43.68 | 35.0 |
140 | 435.91 | 478.38 | 26.70 | 42.47 | 32.0 |
160 | 504.11 | 536.81 | 29.67 | 32.69 | 27.0 |
180 | 569.96 | 587.76 | 31.65 | 17.80 | 20.0 |
Comparison of specific forces and strip crowns with different strip widths
Effect of friction coefficient on exit thickness distribution and specific forces
Friction coefficient | Rolling force (kN) | Intermediate force (kN) | Crown of exit strip ( | Edge contact force (kN) | Edge contact length (mm) |
0.07 | 362.04 | 365.20 | 31.61 | 3.17 | 9.0 |
0.10 | 504.11 | 536.81 | 29.67 | 32.69 | 27.0 |
0.13 | 686.28 | 776.22 | 25.91 | 89.94 | 40.0 |
Comparison of specific forces and strip crowns with different friction coefficients
Distribution of friction coefficient along the strip width
The effects of the transverse friction on the strip profile and specific forces i.e. the rolling force, intermediate force and edge contact force are shown in Figs. 16 and 17. It can be seen that the transverse friction has a significant effect on the strip profile. As the friction coefficient at the edge of strip increases, the exit crown of strip reduces, which indicates that the strip shape becomes better. Thus the strip shape and profile of thin strip can be improved by increasing the edge friction along the strip width. It can also be seen that the rolling force P increases significantly with the friction coefficient at the edges of strip. The intermediate force Q and edge contact force P increase substantially with a higher friction coefficient at the edge of strip, and the length of edge contact also increases. Therefore, the length of edge contact can be determined from this developed model, which is helpful in understanding the feature of the thin strip rolling with work roll edge contact.
Effect of transverse friction on strip shape
In order to verify the simulation results, the clod rolling of thin strip was conducted in lab. When the rolling speed is 0.27 m/s, entry thickness of strip is 0.55 mm, exit thickness 0.12 - 0.17 mm, strip widths 100 - 160 mm, a low carbon steel was rolled on Hille 100 rolling mill, friction coefficient is 0.1, its deformation resistance as described in Eq. (30) replaces Eq. (22) in the simulation.
Effect of transverse friction on specific forces
Other rolling mill parameters are the same as above. Comparison of the calculated rolling forces with the measured values for various strip widths is shown in Fig. 18. It can be seen that the calculated rolling force increases with the strip width, and it is in good agreement with the measured value. Fig. 19 shows a comparison of the measured rolling force with the calculated rolling force under various strip widths and rolling speeds. It can be seen that the rolling force decreases significantly with an increase of the rolling speed. The variation of interference friction features between the roll and strip under various rolling speeds is the main reason for this result. The calculated rolling force is in good agreement with the measured value, which verifies the plastic deformation model we have developed for this thin strip rolling. At lower rolling speeds, the work roll edge contact force becomes higher.
Comparison of the calculated rolling forces with the measured values
Effects of the rolling speeds and strip widths on rolling forces
The average percentages of work roll edge contact force with respect to the total rolling force for various strip widths are 15.0 and 15.6 % for rolling speeds of 0.27 and 0.15 m/s, respectively. Therefore, the work roll edge contact force plays an important role in this rolling process.
A new model for rolling mechanics of thin strip in cold rolling has been developed successfully when the work rolls edge contacts. A strip plastic deformation-based model of the rolling force was employed in the calculation, and a modified semi-infinite body model was introduced to calculate the flattening between the work roll and backup roll, and the flattening between the work roll and strip, as well as a Foppl model was employed to calculate the edge contact between the upper and down work rolls. Based on the theory of the slit beam, the special rolling and strip deformation was simulated using a modified influence function method.
The calculated results show that the specific forces such as the rolling force, intermediate force and the shape and profile of the strip for this special rolling process are significantly different from the forces in the traditional cold rolling process, and those form a new theory of metal plasticity in metal rolling. The edge contact of the work rolls can improve the strip shape when no work roll bending force is applied. With an increase of reduction, the rolling force, intermediate force and edge contact force increase significantly, however the strip shape becomes poor. Strip width has a significant influence on the edge contact force and edge contact length of the work rolls, which can result in an unstable work roll edge wear. When the friction coefficient increases, the edge contact force between the two work rolls increases, this can improve the strip profile. The transverse friction has a significant effect on the rolling force, edge contact force and the length of edge contact. It affects the strip shape and profile significantly, which is helpful in improving the strip shape and profile by modifying transverse friction. The calculated rolling force increases when the strip width increases and the rolling speed decreases, and it is in good agreement with the measured value. At lower rolling speeds, the work roll edge contact force becomes higher as a percentage of the total rolling force.
B Width of strip
Fl Roll flattening
F Friction coefficient
H1 Slab thickness
H Entry thickness of strip
H Exit thickness of strip
k
k
k
Yw Roll deflection
Β Constant
The work was supported by Australian Research Council (ARC) Discovery-Project grant including an Australian Research Fellowship.
Tabu search is a meta heuristic problem solving approach used to solve combinatorial optimization problems. It was first proposed by Glover [1] and further developed by Hansen [2]. TS has now become an established search procedure and has been successfully applied to solve a wide spectrum of optimization problems [3, 4, 5, 6, 7, 8, 9].
TS uses a memory which allows it to remember the current best solution and also enables it to explore the previous solutions and to direct the search moves. The features of memory adaptation and exploration facilitate TS to find better solutions and discover new potential regions in the search space. The memory adaptation feature helps to realize its course of action to exploit the search space efficiently. The ability of TS to explore good solutions enables it to assimilate the intelligent search mechanisms to search for good solutions and to discover new potential regions. The use of adaptive memory helps TS to learn and creates a more flexible and effective search strategy compared with memory less methods, such as simulated annealing (SA) and genetic algorithms (GA).
The components of TS are explained as follows.
To optimize the function
The tabu list in TS maintains the data of the previously visited solutions. The list is included with the latest moves and it is altered dynamically as the search proceeds. The data in the tabu list helps to direct the move from the present solution to the next solution. At each iteration, the search process is maintained by updating the tabu list. The tabu list also avoids re-visiting of recent neighbors recorded in the list and thus save computational time.
The information is stored in tabu list as recency-based short-term memory (RSM) and a frequency-based long-term memory (FRM). When the search proceeds, the nearly better solution to the present solution is sorted as tabu, and added to the recency-based tabu list. As fresh solutions enter the list, older solutions are removed from the bottom. Long-term memory relies on the frequency of a solution that is visited. When the tabu list is filled with the highest number of elements in the frequency based tabu list, the solution with the smallest frequency index will be replaced.
These strategies are used to create neighbors that have higher likelihood of finding optimal solutions based on the data in the tabu list. Intensification strategies are used to search potential areas in detail around the areas that are found good in the past. Intensification strategies are generally employed based on long term memory whose components are used to create neighbors for search intensification [4, 6, 10]. Diversification strategies are used to search the complete viable region, thus restricting the search getting trapped in local optima. These strategies promote probing unvisited regions by creating solutions radically different from those searched earlier [4]. A frequency-based tabu list is used to keep track of the search area.
During the generation of neighbor solutions, the difference between the present and fresh neighbor solution is managed by using a coefficient,
Here
The TS conditions at times prevent moves leading to unvisited solutions. Aspiration criterion is a condition that can override the tabu status of a certain move. To avoid certain missing solutions during the search, the aspiration criterion in certain cases may invalidate the tabu property and maintains an appropriate balance between diversification and intensification [4, 10, 11].
An aspiration criterion that is designed based on a sigmoid function as given by
where
A stopping criterion is needed to terminate the search when the optimum is reached. The stopping criterion can be in the form of fixing the number of iterations or specifying a threshold for convergence of solution. The criteria like the maximum time termination [6] and termination-on convergence criteria [10] are also used as stopping criteria for the search process. The termination-on-convergence criteria is expressed by Lin and Miller [10] as.
where
The flow chart of TS algorithm is shown in Figure 1. Tabu Search begins with an initial solution
Flow chart of the TS algorithm.
TS is implemented using the following steps.
Starts with an initial solution xo
Find the best solution, x* and define tabu list
Neighbor’s generations and neighborhood search
Define a neighborhood structure with respect to the solution space
Change the present solution to form a neighborhood of possible solutions
TS explore neighbor solution at each iteration
Searches entire neighborhood and select enhanced solution
Tabu list
Majority of the recent solutions are in tabu list
Older solutions are discarded
Short-term memory and long-term memory
Recency-based short-term memory (RSM)
Frequency-based long-term memory (FRM)
Intensification and Diversification
To search potential areas
To search whole feasible region
Aspiration criterion
To explore unvisited solutions
To evade feasible missing solutions
Stopping criteria
According iterations
Stopping on convergence
The determination of open-loop time varying control policies that maximize or minimize a given performance index is referred as optimal control. The optimal control policies that guarantee the product property requirements and the operational constraints can be computed off-line, and are executed on-line in such a way that the process is operated in accordance with these control policies. Achievement of product quality is a major issue in polymerization processes since the molecular or morphological properties of a polymer product majorly influences its physical, chemical, thermal, rheological and mechanical properties as well as polymer applications. In a free radical copolymerization, composition drifts caused by variations in reactivities of comonomers can be mitigated by continuous addition of more reactive monomer while maintaining a constant mole ratio. The end use properties of the polymer product such as flexibility, strength and glass transition temperature are affected by the copolymer composition. Further, the molecular weight (
In the past, various methods have been reported for optimal control of polymerization reactors [12, 13, 14, 15, 16]. Most of the studies are based on classical methods of optimization such as Pontryagin’s maximum principle [17], which has been applied to solve the optimal control problems of different polymerization reactors [18, 19, 20, 21, 22, 23]. However, the classical methods have certain limitations for optimal control of polymerization reactors and these drawbacks have been discussed in literature [24]. The stochastic and evolutionary optimization methods are found beneficial over the conventional gradient-based search techniques because of their ability in locating the global optimum of multi-modal functions and searching design spaces with disjoint feasible regions.
The general open-loop optimal control problem of a lumped parameter batch/semi-batch process with fixed terminal time can be stated as follows. Find a control vector
Subject to
In the above,
A multistage optimization results due to the natural extension of a single stage optimization. In a system involving multiple stages, the output from one stage becomes the input to the subsequent stage. The multistage dynamic optimization procedure can be referred elsewhere [24]. This type of optimization needs special techniques to split the problem into computationally manageable units. In multistage dynamic optimization, the optimal control problem of the entire batch duration is divided into finite number of time instants referred to as discrete stages. The control variables and the corresponding state variables that satisfy the objective function are evaluated in stage wise manner.
In this work, a multistage dynamic optimization strategy with sequential implementation procedure is presented for optimal control of polymerization reactors. The procedure for solving the optimal control problem is similar to that of the dynamic programming based on the principle of optimality [25]. The meta heuristic features of tabu search (TS) are exploited by implementing this strategy on a semi-batch styrene–acrylonitrile (SAN) copolymerization reactor. The procedure involves in discretizing the process into
1. The optimum value of the objective function,
2. The value of the objective function,
3. Recursive generalization of the above procedure for the
In this procedure,
The solution copolymerization of styrene and acrylonitrile taking place in a semi-batch reactor is considered as a test bed for sequential implementation of the dynamic optimization strategy. The xylene is the solvent and AIBN is the initiator for the reaction. The feed which is a mixture of monomers, solvent, and initiator enters the reactor in semi-batch mode. The reactor initial volume is 1.01 L. The initially set design parameters are the solvent mole fraction
Initiation:
Propagation:
Combination termination:
Disproportionation termination:
Chain Transfer:
where
The molecular weight (
where
More details on modeling equations, reaction kinetics and numerical data pertaining to this system can be referred elsewhere [24].
The polymerization process model [24] is in the form of the general expression in Eq. (5). The set of state variables,
and
In the above,
The desired values of copolymer composition (
Here
These constraints on operating variables are selected by taking into consideration of reaction rate, heat transfer limitation and reactor safety. Determination of temperature policy,
The design and implementation of tabu search for optimal control of copolymerization reactor is explained as follows. The total span of reaction time in SAN copolymerization reactor is split into finite number of time instants referred to discrete stages. The total time of reaction is fixed at 300 min. The duration of reaction time is divided into 19 stages with 20 time points, each stage having a duration of 15 min. Thus the discrete control sequences of feed flow rate,
The control sequences are located at equal distances. Initially, the control vector is specified as constant value at each of the discrete stages. The control input at the beginning of the first stage is chosen as the lower bound of the input space. The elements of tabu search for computing the optimal control policies are specified as follows. The sizes of both recency and frequency based tabu lists are set as 50. The sizes of these lists are chosen such that they prohibit revisiting of un-prosperous solutions in the search process. An intensification procedure in the form of a sine function is used. The oscillation period
Multistage dynamic optimization of copolymerization reactor using tabu search.
Tabu search (TS) is designed and applied to compute the optimal control policies that meet the single and multiple objectives of SAN copolymerization reactor. The dual control policies of
Dual control policies and objectives: (a) Temperature policy, (b) Feed rate policy, (c) Molecular weight as an objective, and (d) Copolymer composition as an objective.
Strategy | Control Policy | Computational efficiency | Normalized absolute error | Memory storage, k | |
---|---|---|---|---|---|
Convergence time (sec) | Implementation time (sec) | ||||
TS | T | 1.89 | 16.83 | 0.000566 | 2224 |
U | 2.19 | 13.81 | 0.01379 | 2076 | |
T & u | 4.25 | 19.21 | 0.007535 | 3084 |
Computational efficiencies of TS strategy.
Tabu search is applied to determine the parameters of kinetic and film thickness models through the validation of the mathematical models of the process with the help of measured data acquired from an experimental fixed bed anaerobic biofilm reactor used in the treatment of pharmaceutical industry wastewater.
The schematic of a laboratory scale fixed bed biofilm reactor setup used for industry waste water treatment is shown in Figure 4. The description of the experimental unit, its auxiliary items and the packing specifications are given as follows.
Experimental biofilm reactor setup.
The reactor consists of a QVF glass column of 1 m height and 0.1016 m internal diameter. A Teflon perforated plate of thickness 3 mm is provided at the base of the column to support the packing material. Two openings fitted with valves made of Teflon are provided at the bottom of the reactor so that one valve is used to control the flow rate of influent pumped into the reactor and the other valve is used to discharge the excess sludge accumulated. The top of the column has a provision to place a thermometer to measure the temperature. Three sampling ports are placed at equal distances along the side of the column to withdraw samples. The temperature of the column is maintained by varying the voltage through the 0.2 kW heating tape connected to a dimmer-stat. The column is insulated with 1.0 in. asbestos rope. The entire setup is supported by a 1.0 in. M.S. pipeline structure. The column and the packing specifications are given elsewhere [27].
The experimental setup shown in Figure 4 is used to conduct experiments for anaerobic treatment of pharmaceutical industry wastewater involving different packing materials with varying organic loading rates and feed rates, and different hydraulic retention times. The influent kept in a 2
The wastewater procured from a typical pharmaceutical industry is a complex medium and its composition is reported elsewhere [28]. Substrates of varying COD concentrations are prepared using the wastewater in order to use them as feed solutions for biofilm reactor experiments. Once the biological activity of the bed is detected, the diluted industry wastewater solution equivalent to three bed volumes is sent to the reactor by an electronic dosing pump. NaHCO3 is added to maintain the pH of the feeding solution at 7.2. Different experiments are conducted for treating the pharmaceutical industry wastewater using the feed solutions having the COD concentrations of 4,980 mg/l, 11,860 mg/l, 23,460 mg/l and 40,720 mg/l. The hydraulic retention time (HRT) of each experiment is varied from 2 to 12 days based on the substrate concentration of the feed solution. Each experimental run subsequent to attainment of its HRT is allowed to continue for 13 days so as the operation reaches stable state condition by that time.
Thirteen experiments are conducted using the different feed solutions prepared from the pharmaceutical industry wastewater. The reactor is provided with the sampling ports to withdraw samples at bed heights of 0.25 m, 0.5 m and 0.75 m from the bottom. Samples collected from the three sampling ports of the column as well as from the effluent water are analyzed for COD, BOD, TVA, TA, pH etc. The stable state condition of each experiment is observed with respect to the minimal variation in reactor effluent pH, alkalinity and COD concentrations. Thus 13 experiments are conducted under different feed stream conditions. The data corresponding to the influent and effluent COD concentrations, HRT and OLR of all experiments are given elsewhere [28].
The application of mathematical models to biofilm reactors suffers due to lack of availability accurate kinetic models and uncertainty in model parameters. Therefore, appropriate selection of kinetic model and accurate determination of its parameters is required for successful modeling of biofilm reactors. The biological reaction rates are generally represented by Monod kinetics and also occasionally by Contois and Haldane models. In the past, efforts have been made to determine the parameters of kinetic models of biofilm reactors, mostly experimentally [29, 30, 31]. Various researchers [32, 33, 34, 35] have reported that numerical evaluation of kinetic parameters is an attractive alternative to the experimental methods for biofilm processes. By numerical approach, the parameters of the kinetic models of biofilm processes are determined as a consequence of the validation of their mathematical models with the aid of measured data. The approach of determining the model parameters such that the behavior of the process model approximates the observed process behavior is known as inverse modeling.
Mathematical models of varying complexities involving different types of kinetic and film thickness models are used to represent the wastewater treatment process in the biofilm reactor.
This model accounts the rate of mass transfer to be proportional to the concentration difference between the interface and the bulk fluid. This model assumes no accumulation of the component at the interface under steady state condition. The differential equation governing the fluid phase is given by.
with the boundary condition:
In this model, the substrate concentration in the bulk fluid varies only in the axial direction.
The differential equation governing the solid phase is given by.
with the boundary conditions:
The superscript ‘
This model considers the variation of the substrate concentration in bulk fluid in both the axial and radial directions. The substrate transfer occurring through the biofilm is characterized by physical diffusion and reaction, and this process is described by second order differential equation. Pressure losses along the length of the reactor are neglected. The differential equation governing the bulk fluid phase is given by.
where
The substrate mass transport occurring from the bulk fluid to the biofilm surface across the diffusion layer is defined by
where Sc is Schmidt number (
where
Various kinetic models can be used to represent the bioprocess kinetics [28], of which the Haldane and Edward models are given as follows.
This rate expression is generally valid when the substrate concentration is high. According to this model, the substrate consumption rate,
where
This model considers substrate inhibition, according to which the substrate consumption rate,
The biofilm thickness (
where
To facilitate the solution of mathematical models, the height of the column (1 m) is divided into 50 equal steps, each step representing 0.02 m. In one dimensional model, the fluid phase equation (Eq. (27)) along with its boundary condition (Eq. (28)) is solved for each height step in the axial direction by using Runge–Kutta (RK) 4th order method. The solid phase equation for the biofilm (Eq. (29)) is solved for each segment using orthogonal collocation on finite elements (OCFE) [36]. Two finite elements, each with four internal collocation points are considered for OCFE implementation. In two dimensional model, the fluid phase equation (Eq. (31)) is transformed to ODE by finite difference technique and the resulting equation along with its boundary condition is solved by using 4th order RK method for each height step of the axial direction. The solution for solid phase equation of this model is same as in one dimensional model.
The implementation procedure of tabu search is given in Section 1.3. In this work, tabu search is used to determine the parameters of kinetic and film thickness models in association with the validation of the mathematical models using the data of measurements obtained from an experimental fixed bed anaerobic biofilm reactor. The parameter estimation via inverse modeling is carried out by defining an objective function,
where
Parameter estimation by tabu search is performed by devising different modeling configurations to represent the biofilm reactor. These configurations involve the Edward kinetics and Haldane kinetics with substrate inhibition along with the two and three parameter film thickness expressions. The modeling configuration that is formed by 1D model along with Haldane kinetics and two parameter film thickness expression is referred to 1D-Haldane-2film. Other modeling configurations are formed and abbreviated in the same manner. The effectiveness of these modeling configurations are assessed by comparing the model predictions with experimental data and further by means of performance measures such as cost function (CF) and model efficiency (ME) [28]. A conventional optimization method called Nelder–Mead optimization (NMO) [37, 38] is also employed for comparison with the tabu search. The results are analyzed to find the better suitability of mathematical models using the quantitative performance measures (CF and ME). These results evaluated for 1D and 2D models with Haldane and Edward kinetics involving two film and three film expressions indicate the better suitability of 2D model over 1D model. When the results are analyzed to assess the better suitability optimization algorithm, the analysis of results of different modeling configurations indicate the effectiveness of TS over NMO. The results evaluated to find the usefulness of kinetic models indicate the better suitability of Edward kinetics over Haldane kinetics. The results analyzed to assess the film thickness expressions indicate the appropriateness of the three parameter film thickness expression over two parameter expression. The iterative convergence of parameters estimated by TS and NMO are shown in Figure 5. The comparison of the prediction results of 2D model with Edward kinetics and three parameter film thickness expression evaluated using TS and NMO with those of experimental results are shown in Figure 6. The analysis of the results show the better performance of TS over NMO for inverse modeling of biofilm reactor. From these results, it is found that the TS involving 2D model, Edward kinetics and three parameter film thickness expression better represents the fixed bed biofilm reactor involved in the treatment of pharmaceutical industry wastewater.
Iterative convergence of parameter estimates by TS and NMO: (a) kinetic parameters, (b) film thickness parameters.
Comparison of experimental results with model predicted substrate conversions of 2D model with Edward kinetics.
Tabu search is a stochastic optimization method used to solve global optimization problems. The effectiveness of tabu search for modeling and optimization is explored with the applications concerning to chemical and environmental systems of varying complexities. The meta heuristic Tabu search (TS) is designed and applied to determine the optimal control policies of a SAN copolymerization reactor and inverse modeling of a biofilm reactor. The computational efficiencies of TS are evaluated in terms of execution times, normalized absolute error values and memory storage requirements. The results of polymerization reactor show the usefulness of TS in determining the optimal temperature and feed rate policies to maintain the objectives
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\\n\\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\\n\\nLicense
\\n\\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\\n\\nPeer Review Policies
\\n\\nAll scientific works are Peer Reviewed prior to publishing. Read more
\\n\\nOA Publishing Fees
\\n\\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\\n\\nDigital Archiving Policy
\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n\\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\\n\\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\\n\\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\\n\\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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This chapter will focus on usage of virtual reality in occupational therapy, history and recent developments, types of virtual reality technologic equipment, pros and cons, usage for pediatric, adult and geriatric people and recent research and articles.",book:{id:"5711",slug:"occupational-therapy-occupation-focused-holistic-practice-in-rehabilitation",title:"Occupational Therapy",fullTitle:"Occupational Therapy - Occupation Focused Holistic Practice in Rehabilitation"},signatures:"Orkun Tahir Aran, Sedef Şahin, Berkan Torpil, Tarık Demirok and\nHülya Kayıhan",authors:[{id:"172938",title:"Prof.",name:"Hulya",middleName:null,surname:"Kayihan",slug:"hulya-kayihan",fullName:"Hulya Kayihan"},{id:"183079",title:"Ph.D.",name:"Sedef",middleName:null,surname:"Şahin",slug:"sedef-sahin",fullName:"Sedef Şahin"},{id:"196848",title:"M.Sc.",name:"Orkun Tahir",middleName:null,surname:"Aran",slug:"orkun-tahir-aran",fullName:"Orkun Tahir Aran"},{id:"197159",title:"Mr.",name:"Tarık",middleName:null,surname:"Demirok",slug:"tarik-demirok",fullName:"Tarık Demirok"},{id:"197312",title:"M.Sc.",name:"Berkan",middleName:null,surname:"Torpil",slug:"berkan-torpil",fullName:"Berkan Torpil"}]},{id:"61806",doi:"10.5772/intechopen.78312",title:"Executive Functions and Neurology in Children and Adolescents",slug:"executive-functions-and-neurology-in-children-and-adolescents",totalDownloads:1759,totalCrossrefCites:3,totalDimensionsCites:5,abstract:"This chapter discusses the theoretical and methodological issues of creating a developmental perspective on executive function (EF) in childhood and adolescence. Focusing on school periods, this section outlines the development of the basic components of EF—inhibition, working memory, and attention. Cognitive and neurophysiological evaluations show that despite the emergence of EF in the first few years of life, it continues to grow significantly in childhood and adolescence. The components vary slightly according to their developmental sequence. The chapter links findings to long-standing developmental issues (i.e. developmental sequences and processes) and suggests the necessary research to establish a developmental framework covering early childhood throughout adolescence.",book:{id:"6772",slug:"occupational-therapy-therapeutic-and-creative-use-of-activity",title:"Occupational Therapy",fullTitle:"Occupational Therapy - Therapeutic and Creative Use of Activity"},signatures:"Gokcen Akyurek",authors:[{id:"197265",title:"Dr.",name:"Gokcen",middleName:null,surname:"Akyurek",slug:"gokcen-akyurek",fullName:"Gokcen Akyurek"}]},{id:"55024",doi:"10.5772/intechopen.68463",title:"Occupational Therapy in Oncology and Palliative Care",slug:"occupational-therapy-in-oncology-and-palliative-care",totalDownloads:2699,totalCrossrefCites:1,totalDimensionsCites:4,abstract:"Cancer is a chronic disease that may occur in both children and adults. Occupational therapy focuses on the activity limitations and participation problems in their life. Oncology rehabilitation involves in helping an individual with cancer to regain maximum physical, psychological, cognitive, social, and vocational functioning with the limits up to disease and its treatments in an interdisciplinary team concept. These treatment options are associated with the risk of some side effects, including fatigue, pain, cognitive problems, decrease in bone density and muscle endurance, weight loss, and stress- or anxiety-related psychosocial problems. Occupational therapy approaches are a holistic view in a client center and use training in activities of daily living, assistive technology, education of energy conservation techniques, and management of treatment-related problems, such as pain, fatigue, and nausea. In palliative and hospice care, occupational therapists support clients with cancer by minimizing the secondary symptoms related to cancer and its treatments. At the end of life, occupational therapy offers to identify the roles and activities that are meaningful and purposeful to the client with cancer and try to determine the barriers that limit their performance. Clients with cancer who have childhood cancer or adult cancer can face problems about body structure and functions, activity, and participation, which may limit their participation to their daily life.",book:{id:"5711",slug:"occupational-therapy-occupation-focused-holistic-practice-in-rehabilitation",title:"Occupational Therapy",fullTitle:"Occupational Therapy - Occupation Focused Holistic Practice in Rehabilitation"},signatures:"Sedef Şahin, Semin Akel and Meral Zarif",authors:[{id:"183079",title:"Ph.D.",name:"Sedef",middleName:null,surname:"Şahin",slug:"sedef-sahin",fullName:"Sedef Şahin"},{id:"183078",title:"Dr.",name:"Burcu Semin",middleName:null,surname:"Akel",slug:"burcu-semin-akel",fullName:"Burcu Semin Akel"},{id:"198859",title:"Dr.",name:"Meral",middleName:null,surname:"Zarif",slug:"meral-zarif",fullName:"Meral Zarif"}]},{id:"56049",doi:"10.5772/intechopen.69101",title:"Measurement of Participation: The Role Checklist Version 3: Satisfaction and Performance",slug:"measurement-of-participation-the-role-checklist-version-3-satisfaction-and-performance",totalDownloads:2823,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"Participation in society is an area of interest to both clinicians and population researchers. Measurement of participation is therefore important, yet differences in definition, in terms of both content and scope, have made general agreement on one instrument tool elusive. What is recognized is the need for a theoretically based tool that captures both the insider and the outsider perspective. The outsider perspective, inclusive of the generally held views of a society, supports the utility for aggregating population data, whereas the insider perspective provides the internally held views of an individual needed for client-centered treatment planning. The Role Checklist Version 3 modifies one of the most commonly used assessment tools in occupational therapy practice, has good preliminary psychometric properties, and is theoretically consistent with both the ICF and the Model of Human Occupation. The Model of Human Occupation is the most widely used theoretical model in occupational therapy. This chapter provides an overview of the theoretical development, empirical testing, and implications for use of this participation measure by occupational therapists along with implications for population researchers.",book:{id:"5711",slug:"occupational-therapy-occupation-focused-holistic-practice-in-rehabilitation",title:"Occupational Therapy",fullTitle:"Occupational Therapy - Occupation Focused Holistic Practice in Rehabilitation"},signatures:"Patricia J. Scott, Kelsey McKinney, Jeff Perron, Emily Ruff and Jessica\nSmiley",authors:[{id:"195495",title:"Dr.",name:"Patricia J",middleName:null,surname:"Scott",slug:"patricia-j-scott",fullName:"Patricia J Scott"},{id:"208801",title:"Dr.",name:"Kelsey G.",middleName:null,surname:"McKinney",slug:"kelsey-g.-mckinney",fullName:"Kelsey G. McKinney"},{id:"208802",title:"Mr.",name:"Jeffrey M.",middleName:null,surname:"Perron",slug:"jeffrey-m.-perron",fullName:"Jeffrey M. Perron"},{id:"208803",title:"Dr.",name:"Emily G.",middleName:null,surname:"Ruff",slug:"emily-g.-ruff",fullName:"Emily G. Ruff"},{id:"208804",title:"Dr.",name:"Jessica L.",middleName:null,surname:"Smiley",slug:"jessica-l.-smiley",fullName:"Jessica L. Smiley"}]},{id:"55018",doi:"10.5772/intechopen.68315",title:"Psychomotor Therapy for Patients with Severe Mental Health Disorders",slug:"psychomotor-therapy-for-patients-with-severe-mental-health-disorders",totalDownloads:2274,totalCrossrefCites:3,totalDimensionsCites:3,abstract:"Psychomotor therapy is defined as a method of treatment based on a holistic view of the human being that is derived from the unity of body and mind. Assessments (observation and/or evaluation) are essential to achieving concrete psychosocial objectives methodically. Psychomotor therapy uses movement, body awareness and a wide range of movement activities to optimize movement behaviour as well as the cognitive, affective and relational aspects of psychomotor functioning (i.e. the relationships between physical movements and cognitive and social-affective aspects). Consequently, the approach to this type of therapy integrates the physical, cognitive and emotional aspects of functioning in relation to the capacity of being and acting in a psychosocial context in order to achieve clearly defined goals in consultation with the patients. Psychomotor therapy framework consists of three different approaches: a health-related approach, a psychosocial approach and a psychotherapeutic approach, which can be embedded in several psychotherapeutic approaches. Through the implementation of both systematically planned evaluations and individually targeted interventions in group, the psychomotor therapist strives to broaden the general action competences and specific skills and to stimulate a positive self-image and personal well-being in balanced social relationships. Today, there is sufficient evidence that psychomotor therapy has a major contribution to both well-being and mental health of patients with severe psychiatric problems. In Flemish psychiatric hospitals, psychomotor therapy is imbedded in different treatment programmes. In this chapter, the theory behind this approach and some practical examples will be provided.",book:{id:"5711",slug:"occupational-therapy-occupation-focused-holistic-practice-in-rehabilitation",title:"Occupational Therapy",fullTitle:"Occupational Therapy - Occupation Focused Holistic Practice in Rehabilitation"},signatures:"Michel Probst",authors:[{id:"196227",title:"Prof.",name:"Michel",middleName:null,surname:"Probst",slug:"michel-probst",fullName:"Michel Probst"}]}],mostDownloadedChaptersLast30Days:[{id:"55080",title:"Life Skills in Occupational Therapy",slug:"life-skills-in-occupational-therapy",totalDownloads:6076,totalCrossrefCites:4,totalDimensionsCites:1,abstract:"Occupational therapy is a health profession that uses the purposeful activities to achieve multiple and complex rehabilitation aims. The main goals of the occupational therapy are to support the reintegration of individuals in daily living skills as well as to increase their independence and autonomy. Interventions of occupational therapists have primarily focused on self-care, productivity, and leisure time activities. Since the life skills includes a wide range of abilities that enable a person to perform personal care and more complicated tasks such as traveling, shopping, community participation etc., occupational therapists provide life skills training programs to meet the needs of the clients. This chapter aims to contribute to the current understanding and practices of life skills from an occupational therapy perspective. The chapter starts with a brief discussion of the importance of life skills in occupational therapy. After this introduction, the first part takes a look at the definition of life skills and identifies core components of life skills. The second part describes assessment and interventions of life skills. The third one gives an overview about school life skills programs for children and adolescents. Finally, the last part explains some life skills programs in people with disadvantages.",book:{id:"5711",slug:"occupational-therapy-occupation-focused-holistic-practice-in-rehabilitation",title:"Occupational Therapy",fullTitle:"Occupational Therapy - Occupation Focused Holistic Practice in Rehabilitation"},signatures:"Hatice Abaoğlu, Özge Buket Cesim, Sinem Kars and Zeynep Çelik",authors:[{id:"197551",title:"Dr.",name:"Hatice",middleName:null,surname:"Abaoğlu",slug:"hatice-abaoglu",fullName:"Hatice Abaoğlu"},{id:"205199",title:"Dr.",name:"Sinem",middleName:null,surname:"Kars",slug:"sinem-kars",fullName:"Sinem Kars"},{id:"205200",title:"Dr.",name:"Zeynep",middleName:null,surname:"Celik",slug:"zeynep-celik",fullName:"Zeynep Celik"},{id:"205203",title:"Ms.",name:"Özge Buket",middleName:null,surname:"Cesim",slug:"ozge-buket-cesim",fullName:"Özge Buket Cesim"}]},{id:"62493",title:"Occupational Therapy in Forensic Settings",slug:"occupational-therapy-in-forensic-settings",totalDownloads:2543,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"It is necessary for a person to comply with the expectations of society and the rules of law to which these expectations are secured. Offenders turn back to the community after the penalty was executed by isolating from society and some occupations. An occupational imbalance is seen in the individuals, during this penalty period and afterward, because of limited occupational participation. As an occupational being, this affects their physical, mental and psychological well-being. Imprisonment is an important practice in criminal law to punish criminals. This may be necessary for the protection of society from criminals, but successful integration into a community after exiting the prison is the most important factor in preventing recidivism. Occupational therapy focuses on health and well-being by using meaningful and purposeful occupations. Occupation involves any activity that people perform or participate in, such as giving care to themselves or others, working, learning, playing games, and interacting with others. From this perspective, the role of occupational therapists in forensic settings is to determine the abilities of these individuals to congregate their deprived freedoms and use them to train them for an independent and autonomous life; to provide a professional orientation, career counseling, and self-esteem; to gain some habits for physical, spiritual and moral life and to reinforce.",book:{id:"6772",slug:"occupational-therapy-therapeutic-and-creative-use-of-activity",title:"Occupational Therapy",fullTitle:"Occupational Therapy - Therapeutic and Creative Use of Activity"},signatures:"Esma Ozkan, Sümeyye Belhan, Mahmut Yaran and Meral Zarif",authors:null},{id:"70122",title:"Parkinson’s Disease Rehabilitation: Effectiveness Approaches and New Perspectives",slug:"parkinson-s-disease-rehabilitation-effectiveness-approaches-and-new-perspectives",totalDownloads:2083,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Parkinson’s disease has been considered one of the most important and common neurodegenerative diseases in the world. Its motor and nonmotor signs determine a huge functional loss, leading the individuals to lose their independence. Although the treatment requires a pharmacological approach, physical therapy has confirmed its importance in this process. Today, neurorehabilitation is indispensable to increase many of the cardinal signs of the disease. Using traditional or technological approaches, physical therapy has reached good results in improving motor and nonmotor functions, as well as the quality of life of Parkinsonians. However, it is important to develop and to fortify the physical therapy approach so that we can provide stronger evidence about our practice.",book:{id:"7543",slug:"physical-therapy-effectiveness",title:"Physical Therapy Effectiveness",fullTitle:"Physical Therapy Effectiveness"},signatures:"Luciana Auxiliadora de Paula Vasconcelos",authors:[{id:"98546",title:"Dr.",name:"Luciana Auxiliadora",middleName:null,surname:"De Paula Vasconcelos",slug:"luciana-auxiliadora-de-paula-vasconcelos",fullName:"Luciana Auxiliadora De Paula Vasconcelos"}]},{id:"62210",title:"Occupational Therapy’s Role in the Treatment of Children with Autism Spectrum Disorders",slug:"occupational-therapy-s-role-in-the-treatment-of-children-with-autism-spectrum-disorders",totalDownloads:2756,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Occupational therapists (OT) offer a wide range of therapies for individuals with ASD on the basis of specific deficits and difficulties. This chapter explores the role that OT plays, and the expertise, in relation to the interdisciplinary team. In addition, it discusses and presents empirical support for several therapeutic approaches commonly used by OTs working with individuals with ASD.",book:{id:"6772",slug:"occupational-therapy-therapeutic-and-creative-use-of-activity",title:"Occupational Therapy",fullTitle:"Occupational Therapy - Therapeutic and Creative Use of Activity"},signatures:"Bryan M. Gee, Amy Nwora and Theodore W. Peterson",authors:null},{id:"55049",title:"Community Participation in People with Disabilities",slug:"community-participation-in-people-with-disabilities",totalDownloads:2436,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Despite the fact that participation is an important building and a valuable target, the conceptualization, identification and measurement methods vary widely. This chapter tried to gain an insider’s perspective from the obstacles that summarize what meaning participation means, how to characterize it, and what prevents and supports participation. Participation is seen as a right and a responsibility attributed to and attributed to both the person and the community. Participation does not take place in a vacuum; the environment dynamically influences participation. The effects of this conceptual framework are discussed for change at the level of evaluation, research and systems to support the participation of the people with disability.",book:{id:"5711",slug:"occupational-therapy-occupation-focused-holistic-practice-in-rehabilitation",title:"Occupational Therapy",fullTitle:"Occupational Therapy - Occupation Focused Holistic Practice in Rehabilitation"},signatures:"Gokcen Akyurek and Gonca Bumin",authors:[{id:"32431",title:"Prof.",name:"Gonca",middleName:null,surname:"Bumin",slug:"gonca-bumin",fullName:"Gonca Bumin"},{id:"197265",title:"Dr.",name:"Gokcen",middleName:null,surname:"Akyurek",slug:"gokcen-akyurek",fullName:"Gokcen Akyurek"}]}],onlineFirstChaptersFilter:{topicId:"198",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo, Ph.D., is a professor in the Department of Engineering, University of Naples “Parthenope,” Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino and Southern Lazio, Italy. Her research interests include multi-criteria decision analysis, industrial plants, logistics, manufacturing, and safety. She serves as an associate editor for the International Journal of the Analytic Hierarchy Process and is an editorial board member for several other journals. 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Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. 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She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. 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His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. 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