Experimental and calculated 13C, 1H NMR chemical shifts (ppm) and 1JCH NMR coupling constants (Hz) of danon.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"8592",leadTitle:null,fullTitle:"Mesoporous Materials - Properties and Applications",title:"Mesoporous Materials",subtitle:"Properties and Applications",reviewType:"peer-reviewed",abstract:"The basic theme of this book is to understand the fundamentals and importance of porous functional materials, their properties, and significant applications like solar cells, batteries, photovoltaics, energy conversions, and mesoporous materials. This book covers the fundamentals of mesoporous materials, and various methods of synthesis, properties, and applications in different sectors.",isbn:"978-1-83880-650-7",printIsbn:"978-1-83880-649-1",pdfIsbn:"978-1-83880-687-3",doi:"10.5772/intechopen.79068",price:119,priceEur:129,priceUsd:155,slug:"mesoporous-materials-properties-and-applications",numberOfPages:130,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"9af59f637c67eec81a23db27d63c1353",bookSignature:"Manjunath Krishnappa",publishedDate:"May 29th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/8592.jpg",numberOfDownloads:7298,numberOfWosCitations:9,numberOfCrossrefCitations:11,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:23,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:43,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 13th 2018",dateEndSecondStepPublish:"August 29th 2018",dateEndThirdStepPublish:"October 28th 2018",dateEndFourthStepPublish:"January 16th 2019",dateEndFifthStepPublish:"March 17th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"202044",title:"Dr.",name:"Manjunath",middleName:null,surname:"Krishnappa",slug:"manjunath-krishnappa",fullName:"Manjunath Krishnappa",profilePictureURL:"https://mts.intechopen.com/storage/users/202044/images/system/202044.jpeg",biography:"Krishnappa Manjunath received masters degree from the Sri Venkateshwara University, Tirupathi. He received Ph.D. from Jain University, India in Chemistry under the guidance of Prof. T. Ramakrishnappa in 2016. During his Ph.D., he was awarded a prestigious ‘CNPq-TWAS’ fellowship in 2014 for 1-year internship and worked with Prof. Jairton Dupont, FRS at Laboratory of Molecular Catalysis, UFRGS, Brazil. In 2016, he joined at International Centre for Materials Science, JNCASR, Bangalore where he is currently working as Research Associate with Bharat Ratna Prof. C. N. R. Rao, FRS. His research interests mainly focus on ‘Investigations on aliovalent anion substitution in inorganic materials and their applications for water splitting reactions to generate hydrogen’. He authored more than 30 papers, mainly concerning advanced functional materials and nanomaterials for photocatalysis.",institutionString:"Jawaharlal Nehru Centre for Advanced Scientific Research",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Jawaharlal Nehru Centre for Advanced Scientific Research",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"156",title:"Composite Materials",slug:"materials-science-composite-materials"}],chapters:[{id:"65758",title:"Synthesis and Characterizations of Titanium Tungstosilicate and Tungstophosphate Mesoporous Materials",doi:"10.5772/intechopen.82405",slug:"synthesis-and-characterizations-of-titanium-tungstosilicate-and-tungstophosphate-mesoporous-material",totalDownloads:943,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The work reports a development approach for the synthesis of novel multi-components mesoporous materials of titanium tungstate (meso-TiW) titanium tungstosilicate (meso-TiWSi) and tungstophosphate (meso-TiWP) mixed oxides that have high surface area and ordered mesoporous structures at nanometer length scale. Using the solvent evaporation-induced self-assembly (EISA) new oxides of bi- and tri-component of meso-TiW, meso-TiWSi and meso-TiWP oxides with different compositions and porosity were achieved. The physicochemical properties of the mesoporous oxides were characterized by X-ray diffraction, BET surface area analyzer, scanning, and transmission electron microscopes. Subject to the oxide composition, the obtained meso-TiW, meso-TiWSi and meso-TiWP exhibits high surface area, ordered 2D hexagonal mesostructured with order channels extended over a large area. The produced meso-TiW, meso-TiWSi, and meso-TiWP adsorbents exhibit good adsorption efficiency for the removal of Pb(II), Cd(II) and Hg(II) ions from water solution due to the presence of high surface area and accessibility of surface active sites. The adsorption efficiency of these mesoporous oxide reaches up to 95% and is found to be dependent contact time and adsorbents dose. The synthesis strategy is particularly advantageous for the production of new complex (multi-component) inorganic mesoporous materials that might have an application in the field of environmental, catalysis or energy storage and production.",signatures:"Mohamed A. Ghanem, Abdullah M. Al-Mayouf and Mabrook S. Amer",downloadPdfUrl:"/chapter/pdf-download/65758",previewPdfUrl:"/chapter/pdf-preview/65758",authors:[{id:"277689",title:"Prof.",name:"Mohamed",surname:"Ghanem",slug:"mohamed-ghanem",fullName:"Mohamed Ghanem"},{id:"277698",title:"Prof.",name:"Abdullah M.",surname:"Al-Mayouf",slug:"abdullah-m.-al-mayouf",fullName:"Abdullah M. Al-Mayouf"},{id:"277700",title:"Mr.",name:"Mabrook S.",surname:"Amer",slug:"mabrook-s.-amer",fullName:"Mabrook S. Amer"}],corrections:null},{id:"65289",title:"Mesoporous Materials Prepared Using Cashew Nut Shell Liquid and Castor Oil as Surfactants",doi:"10.5772/intechopen.83695",slug:"mesoporous-materials-prepared-using-cashew-nut-shell-liquid-and-castor-oil-as-surfactants",totalDownloads:948,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Preparation of useful materials using renewable resources, which are not in competition with food production is of particular importance in the current efforts to replace non-renewable resources. One example of a potential renewable resource, which is attracting the attention of researchers in the preparation of useful materials is cashew nut shell liquid (CNSL). CNSL which is a by-product of cashew processing factories, is a mixture of four potential compounds, namely anacardic acid, cardanol, cardol and 2-methyl cardol. Among other potential applications, cashew nut shell liquid is a good template source for preparation of mesoporous materials. Heterogeneous catalysts prepared using CNSL templates are more efficient than those prepared using the commercially available templates. The pore sizes of mesoporous materials prepared using CNSL templates are large (up to 25 nm) enough to immobilize enzymes. Another renewable resource; castor oil, has also been reported to be a good template source for preparation of mesoporous materials. This chapter therefore is aimed at describing in detail the preparation, characterization and applications of mesoporous materials templated by cashew nut shell liquid and castor oil.",signatures:"James Mgaya and Egid Mubofu",downloadPdfUrl:"/chapter/pdf-download/65289",previewPdfUrl:"/chapter/pdf-preview/65289",authors:[{id:"280637",title:"Dr.",name:"James",surname:"Mgaya",slug:"james-mgaya",fullName:"James Mgaya"},{id:"280756",title:"Prof.",name:"Egid",surname:"Mubofu",slug:"egid-mubofu",fullName:"Egid Mubofu"}],corrections:null},{id:"65810",title:"Synthesis of MCM-41/ZIF-67 Composite for Enhanced Adsorptive Removal of Methyl Orange in Aqueous Solution",doi:"10.5772/intechopen.84691",slug:"synthesis-of-mcm-41-zif-67-composite-for-enhanced-adsorptive-removal-of-methyl-orange-in-aqueous-sol",totalDownloads:835,totalCrossrefCites:4,totalDimensionsCites:9,hasAltmetrics:0,abstract:"ZIF-67 and MCM-41/ZIF-67 composites were successfully synthesized with water solvent at room temperature. The amounts of MCM-41 added during synthesis were varied at 2.5, 5 and 10 (%w/w) toward the amount of ZIF-67, and the obtained solids were denoted as MC (2.5)/ZIF-67, MC (5)/ZIF-67, and MC (10)/ZIF-67, respectively. The X-ray diffraction (XRD) patterns of ZIF-67 and the composites showed characteristic peaks at 2θ of 7.32, 10.36, 12.69, 14.66, and 16.40°, similar to that of reported ZIF-67. The Fourier transform infra-red (FT-IR) spectra of all solids showed absorption bands at the same wavenumbers as reported for ZIF-67. The results of surface morphology analysis using scanning electron microscope (SEM) have shown that ZIF-67 and the composites have a cube shape, which is characteristic for the ZIF-67 standard. N2 adsorption-desorption data showed that the specific surface area of ZIF-67 and MC (5)/ZIF-67 were 1079.2 and 1011.2 m2/g, respectively, lower than that of MC (10)/ZIF-67 (1250.6 m2/g). However, results of thermal gravimetric analysis (TGA) showed that the thermal stability of MC (10)/ZIF-67 reached 357°C, higher than that of ZIF-67 (325°C). Performance of the composites as adsorbent of methyl orange (MO) in aqueous solution showed that the MC (5)/ZIF-67 had the highest adsorption capacity of 167.635 mg/g, and followed the pseudosecond-order adsorption kinetics and Langmuir isothermal adsorption.",signatures:"Ratna Ediati, Pramita Elfianuar, Eko Santoso, Dety Oktavia Sulistiono and Muhammad Nadjib",downloadPdfUrl:"/chapter/pdf-download/65810",previewPdfUrl:"/chapter/pdf-preview/65810",authors:[{id:"264494",title:"Ph.D.",name:"Ratna",surname:"Ediati",slug:"ratna-ediati",fullName:"Ratna Ediati"},{id:"264495",title:"BSc.",name:"Pramita",surname:"Elfianuari",slug:"pramita-elfianuari",fullName:"Pramita Elfianuari"},{id:"272868",title:"MSc.",name:"Eko",surname:"Santoso",slug:"eko-santoso",fullName:"Eko Santoso"},{id:"272870",title:"BSc.",name:"Dety Oktavia",surname:"Sulistiono",slug:"dety-oktavia-sulistiono",fullName:"Dety Oktavia Sulistiono"},{id:"278972",title:"MSc.",name:"Muhammad",surname:"Nadjib",slug:"muhammad-nadjib",fullName:"Muhammad Nadjib"}],corrections:null},{id:"64611",title:"Synthesis, Properties, and Their Potential Application of Covalent Organic Frameworks (COFs)",doi:"10.5772/intechopen.82322",slug:"synthesis-properties-and-their-potential-application-of-covalent-organic-frameworks-cofs-",totalDownloads:2356,totalCrossrefCites:2,totalDimensionsCites:7,hasAltmetrics:0,abstract:"Covalent organic frameworks (COFs) represent an emerging class of crystalline porous polymers, which are ingeniously assembled with organic building blocks through reversible covalent bonds. The well-defined crystalline porous structures, easy functional modification, high surface area, together with structural designability and diversity have offered the COFs superior potential in various applications, such as catalysis, gas adsorption and separation, and optoelectricity. Since the pioneer work of Omar Yaghi in 2005, this field has developed rapidly and attracted much attention from researchers with diverse expertise. In this chapter, we describe the basic design concepts, the recent synthetic advancements, and the frontiers of functional exploration in gas adsorption and storage. Special emphasis is placed on their potential application in heterogeneous catalysis field. Finally, the prospects of COFs and remaining issues in these fields are indicated.",signatures:"Lifeng Deng, Junfeng Zhang and Yanan Gao",downloadPdfUrl:"/chapter/pdf-download/64611",previewPdfUrl:"/chapter/pdf-preview/64611",authors:[{id:"171387",title:"Prof.",name:"Yanan",surname:"Gao",slug:"yanan-gao",fullName:"Yanan Gao"},{id:"265789",title:"BSc.",name:"Lifeng",surname:"Deng",slug:"lifeng-deng",fullName:"Lifeng Deng"},{id:"279899",title:"Mr.",name:"Junfeng",surname:"Zhang",slug:"junfeng-zhang",fullName:"Junfeng Zhang"}],corrections:null},{id:"65916",title:"Designed Mesoporous Materials toward Multifunctional Organic Silica Nanocomposites",doi:"10.5772/intechopen.84875",slug:"designed-mesoporous-materials-toward-multifunctional-organic-silica-nanocomposites",totalDownloads:1244,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Functionalized mesoporous silica materials (MSMs) using grafting (post-synthesis) and one-pot (co-condensation) synthesis methods of organic functional groups (periodic mesoporous organosilicas, PMOs) have been developed for many emerging applications. To improve the functions, designed MSMs have received particular attention using an organic motif as a molecule of surfactants for the template synthesis with a silica source in the sol-gel reaction. The resulting mesoporous silica materials can provide characteristic multifunctional nanocomposites consisting of a monomer for synthesizing polymer in the silicate nanochannels. Moreover, the nanocomposites can be also synthesized using a self-assembled organic motif for organizing one-dimensional structure in the silicate nanochannels. The resulting hybrid nanomaterials have been mainly reported to provide fluorescent properties. However, the utilization of phosphorescent nanocomposites for specific applications has not yet reported so far. By utilizing a self-assembled metal complex (organometallic), this chapter particularly highlights recent achievements of designed mesoporous silica materials for the fabrication of advanced luminescent nanostructures with phosphorescent properties where the potential applications will be discussed in detail for self-repairing and thermally resistive materials, metal ions sensors, template synthesis nanoparticles, and catalysts. Such better and novel performance can be only achieved using a designed template for the sol-gel synthesis of mesoporous silica nanocomposites.",signatures:"Hendrik O. Lintang and Leny Yuliati",downloadPdfUrl:"/chapter/pdf-download/65916",previewPdfUrl:"/chapter/pdf-preview/65916",authors:[{id:"264835",title:"Dr.",name:"Hendrik Oktendy",surname:"Lintang",slug:"hendrik-oktendy-lintang",fullName:"Hendrik Oktendy Lintang"},{id:"265656",title:"Dr.",name:"Leny",surname:"Yuliati",slug:"leny-yuliati",fullName:"Leny Yuliati"}],corrections:null},{id:"66506",title:"Mesoporous Materials for High-Performance Electrochemical Supercapacitors",doi:"10.5772/intechopen.85583",slug:"mesoporous-materials-for-high-performance-electrochemical-supercapacitors",totalDownloads:972,totalCrossrefCites:4,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Supercapacitors are very important kind of electrochemical energy storage devices. It differs from those of batteries and exhibit high power density. The energy storage in supercapacitors is influenced by many parameters like nature of electrode material, current collector, electrolyte, etc. among which most crucial is the morphology of the electrode. This makes most of the research works are targeting in designing suitable and high performing electrode materials by adopting new routes of synthesis, modifying the regular methods so on. Herein we discuss the fundamentals of supercapacitors, their design and approaches to obtain high-performance electrode materials.",signatures:"Ranganatha Sudhakar",downloadPdfUrl:"/chapter/pdf-download/66506",previewPdfUrl:"/chapter/pdf-preview/66506",authors:[{id:"271773",title:"Dr.",name:"Ranganatha",surname:"Sudhakar",slug:"ranganatha-sudhakar",fullName:"Ranganatha Sudhakar"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6513",title:"Cement Based Materials",subtitle:null,isOpenForSubmission:!1,hash:"7c92db3d5c64117861b425cb692b5695",slug:"cement-based-materials",bookSignature:"Hosam El-Din M. Saleh and Rehab O. Abdel Rahman",coverURL:"https://cdn.intechopen.com/books/images_new/6513.jpg",editedByType:"Edited by",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. 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Pereira and Fábio A. O. Fernandes",coverURL:"https://cdn.intechopen.com/books/images_new/7610.jpg",editedByType:"Edited by",editors:[{id:"211131",title:"Prof.",name:"António",surname:"Pereira",slug:"antonio-pereira",fullName:"António Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7277",title:"Optimum Composite Structures",subtitle:null,isOpenForSubmission:!1,hash:"d25c7d0dfa4679385ef2dbc2c0adefa1",slug:"optimum-composite-structures",bookSignature:"Karam Y. Maalawi",coverURL:"https://cdn.intechopen.com/books/images_new/7277.jpg",editedByType:"Edited by",editors:[{id:"18593",title:"Prof.",name:"Karam",surname:"Maalawi",slug:"karam-maalawi",fullName:"Karam Maalawi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7762",title:"Advances in Composite Materials Development",subtitle:null,isOpenForSubmission:!1,hash:"4b760434abfb3cca149e9ea09c887dbb",slug:"advances-in-composite-materials-development",bookSignature:"Dumitra Lucan",coverURL:"https://cdn.intechopen.com/books/images_new/7762.jpg",editedByType:"Edited by",editors:[{id:"20132",title:"Dr.",name:"Dumitra",surname:"Lucan",slug:"dumitra-lucan",fullName:"Dumitra Lucan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6847",title:"Characterizations of Some Composite Materials",subtitle:null,isOpenForSubmission:!1,hash:"f0869b3bb91cf9acb7e69004b1bd17ec",slug:"characterizations-of-some-composite-materials",bookSignature:"Hosam El-Din M. 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Her laboratory employs morphological, behavioral, and electrophysiological techniques to better understand sensory mechanisms by which larval and adult insects find host plants and detect plant-associated volatiles. Dr. Shields received a BS and Ph.D. from the University of Regina, Regina, Saskatchewan, Canada. A portion of her Ph.D. studies was carried out at the University of Alberta, Edmonton, Alberta, Canada. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"57798",title:"Spectral Calculations with DFT",doi:"10.5772/intechopen.71080",slug:"spectral-calculations-with-dft",body:'Early days of quantum chemistry go back to Thomas-Fermi and Thomas-Fermi-Dirac models of the electronic structure of atoms, which gave the concept of articulating some parts or all of the molecular energy as a functional of the electron density, and then comes the traditional Hartree-Fock (HF) theory [1]. HF theory was a simplest ab initio technique and among the first principles of quantum-chemical theories, being attained directly from the Schrodinger-wave equation that did not incorporate any pragmatic contemplations. Although such theories and techniques proved beneficial, it was density functional theory (DFT) that laid a demanding theoretical foundation in 1964 by an outstanding result established by Hohenberg and Kohn [2].
The Hohenberg-Kohn theorems state that the exact ground state energy of the system is produced by a unique functional of the electron density
where VKS is a local one-body potential defined as total density of the noninteracting system and is the same as the density of a real system.
The density functional theory (DFT) has become a powerful tool in computational chemistry owing to its usefulness. Spectroscopic analysis of chemical entities by this technique emerged as commanding implementation. Prediction of frequencies and spectral intensities by DFT calculations are indispensable nowadays for interpreting the experimental spectra of complex molecules. Much advancement has been made in the past decade to design new DFT approaches that can be employed into available quantum-chemical computational programs. For calculation of the molecular and electronic structures of ground-state systems and various spectral parameters related to NMR, ESR, UV-Vis and IR, various density functional practices are available now. Functionals available today can strive with best previous ab initio methods [5].
For experimental spectroscopists, theoretical computation of vibrational frequencies has become practically essential these days as specifically in problematic and uncertain cases it assists to assign and interpret experimental infrared/Raman spectra. Previously, the HF method was used in many studies to calculate vibrational frequencies, but it has long been identified that this approach miscalculates these frequencies even occasionally to a disturbing degree. Inadequate handling of electron correlation and anharmonicity of the vibrations are found to be the main contributions to error [6]. DFT largely overcome the errors as theoretical computations helped to interpret experimental conclusions depicting that using DFT these theoretical data can nearly be attained at the harmonic level. Calculation of optimized geometry, IR intensities, vibrational frequencies and Raman scattering activities can be done by employing different density functional approaches [7].
Taking NMR spectroscopy into consideration, DFT-based new methods are developed that are appropriate for the satisfactory hypothetical interpretation of NMR spectra of various chemical and biochemical systems. It is obvious that local geometrical and electronic structures influence magnetic resonance parameters, i.e., shielding tensors, nuclear spin-spin coupling parameters, hyperfine tensors and g-tensors. For speculations of NMR parameters, a practical approximation of the real system is depicted by a model system in which 50–100 atoms are treated with ab initio techniques. Over the last years, DFT advanced by the capability to include effects of electron correlation in a very effectual means to the forefront of field of calculating NMR parameters [8, 9].
Competent calculations of excited states properties are emerging field of interest for quantum chemists; hence, they are developing interesting solutions for these properties. Because of advancement of computations based on the time-dependent density functional theory (TD-DFT) [10] in recent years, calculations of electronic structures in the excited states have become a motivation of interest. A commanding method of carrying out exact quantum mechanical calculations of the intervalence absorption spectrum is provided by the time-dependent concept of electronic spectroscopy. A corporeal picture of the effects of the coupling of electronic and nuclear motions became available by employing calculations in the time realm due to reason that the time development of the wave-packet can be tracked and inferred as well [11]. Plentiful successes of this technique have been recently revised as electronic spectra are often calculated with TD-DFT. Vertical excitation energies, absorption wavelength and oscillator strength calculations can be performed by this technique [12].
The influence of vibrational spectroscopy as an analytical tool in several fields is obvious. Qualitative association of bands and specific structures or chemical groups is basic interpretation of vibrational spectra. In contrast to nuclear magnetic resonance where nuclear spin is associated with one peak or multiplet is proved advantageous, united motion of all of the nuclei in sample is reason for observed bands in vibrational spectra. For N nuclei, there are at most 3 N-6 experiential fundamental bands and so far the matrix of internuclear force interactions, i.e., the second derivative matrix in harmonic approximation, has (3 N-6)(3 N -5)/2 exclusive terms. The extraction of force constants from vibrational frequencies is yet an undetermined mathematical problem as many bands are not actually observed; e.g., there are overtones, combination bands and nonconformities from the harmonic approximation; hence, the problem seems obstinate [13].
For the ground state’s potential energy surface computation, discovery of effectual codes delivers a possible answer to the problem. A technique that will precisely determine the bonding, as well as intermolecular interactions, will be helpful for calculating vibrational spectra. The ground state properties and potential energies are accurately calculated by DFT approaches; therefore, DFT excellently and proficiently calculates the vibrational spectra from first principles [7]. The absolute values of the frequencies are high in contrast to experimental values while using DFT models as they seem to characterize the bonding pretty well and comparison with experimental trends is possible. DFT methods give sufficiently high accuracy of normal mode calculations as the restrictions of the harmonic approximation are often a foremost cause of divergence between theory and experiment. It is reasonable to outspread the approach by including molecular interactions after given achievement of the method employed to small molecules. There are two aspects that can be reasons for inconsistency, i.e., anharmonicity and hydrogen bonding, both result in a lower frequency for a specific normal mode than projected by harmonic approximation [14].
Computation of vibrational spectra of molecules in their ground and excited states can be done by using the Gaussian program. The program can also designate the dislocations of the molecule as it undergoes normal modes of vibrations along with prediction of spectral frequencies and intensities. The spectra can be produced from a list of frequencies and intensities employing a Gaussian broadening function as depicted in Eq. (2) [13]:
For each of the
Study of a molecular system behind calculating the vibrational frequencies [7]. If springs are considered Hookean, for example, equations of motion can readily be solved when force is proportional to the displacement and we can find that vibrational frequencies are associated with force constants and masses of atoms. For instance, in a simple molecule like CO where there is only one spring, the frequency is calculated as in Eq. (3).
where
Before calculating the second derivative of energy, the first step in quantum chemical calculations is optimization of molecular geometry. Vibrational frequency calculations are done after optimizing geometry by using the same method and basis set as used for calculating vibrational frequency. Model’s development is constructed on spontaneously rational values for interbond angles, bond distances and dihedral angles in the absence of experimental data. It is usually done by solving the following Schrodinger wave equation [15]:
where
The second derivative of energy regarding the position of nuclei is factor on which molecular frequencies hinge on. Hartree-Fock theory, DFT-B3LYP and other approaches make available the analytic second derivative of energy. Input for frequency calculation is given by the optimized energy [16]. These derivatives are estimated at the equilibrium geometry with origin at the middle of mass by manipulating a set of second derivatives of molecular energy U respecting the 3 N nuclear Cartesian coordinates of a coordinate system as in Eq. (5) [15].
Mass-weighted force constant matrix elements give:
where mi is mass of the nucleus in correspondence to coordinate Xi.
Then, set of 3
If coefficient of determinant vanishes, this set of consistent equations has a nontrivial explanation as follows:
This determinant is of order 3
Calculation of molecular harmonic vibrational frequencies is now done as follows [15]:
By solving Eq. (9), six of the
Zero-point energy is defined as the sum over all the vibrational modes for a molecule with maximum number of vibrational modes and calculated as:
Normal coordinate analysis gives comprehensive explanation of vibrational modes. It is termed a practice that calculates the vibrational frequencies involving observed frequencies of more preferably infrared and Raman harmonic frequencies to equilibrium geometry, force constants and atomic masses of an oscillating system. In assigning vibrational spectra, normal coordinate analysis proved beneficial, but reliable intramolecular force constants influence its predictive ability [17].
DFT syndicates accuracy with computational rapidity and user-friendliness for investigating the ground state characteristics in sturdily bound systems. Consistent highly reliable hybrid DFT methods (discussed in Section 3.1) make them more proficient and endearing. B3LYP functional [18] (discussed in hybrid methods of Section 3.1) is the most extensively used among all hybrid density functional methods as it is considered to give most exact vibrational frequencies of compounds only if calculated frequencies are scaled by a uniform scaling factor. Scaling is done to compensate for all probable causes of inaccuracy produced owing to electronic structure method–related inaccuracies, e.g., basis set insufficiencies and estimated handling of electron-correlation and nuclear motion treatment inaccuracies [19].
Gaussian is a most employed computational chemistry software program, whereas Gauss View is an inexpensive full featured graphical user interface for Gaussian. One can submit inputs to Gaussian and can observe output graphically, which is usually produced by Gaussian software via using Gauss View. For IR spectrum calculations in Gaussian, the following are the steps:
After predicting the number of vibrational modes and expected regions for frequencies for molecule by theoretical calculations, build molecule in Gauss View. Go to Calculate from Gauss View toolbar and select Gaussian. In the Job Type dialog box, select Opt + Freq and optimize to a ‘Minimum’ Calculate Force Constants-\'Never,’ Compute Raman- ‘Default,’ deselect any other option.
In Method section, select ground state (HF, Restricted or DFT Restricted and B3LYP according to required calculation) and select a basis set, Charge-0 and Spin-Singlet. Insert SCF = Tight in the Additional Keywords section and if your calculation is in vacuo, select ‘None’ in the Solvation dialog box. Submit the calculation.
Open the output file of the optimized structure in Gauss View. Verify that the optimization calculation has converged by checking that the maximum force, RMS force, maximum displacement and RMS displacement parameters are all converged.
Go to Results and select the ‘Vibrations’ option. View the IR spectrum by pressing the ‘Spectrum’ button and check out whether the number of modes are in accordance with theoretical calculations or not. Each vibrational mode can be visualized by highlighting it in the ‘Display Vibrations’ table and pressing the ‘Start’ button.
NMR is based on the principle that the energy of a system containing nuclear or electron magnetic moments arising from the spin of a particle, in the existence of an external stationary magnetic field, depends upon the direction of the magnetic moment with respect to the external field. One can thus measure the energy difference for different directions of the electronic magnetic moment (electronic Zeeman effect) or of nuclear magnetic moment (nuclear Zeeman effect) by employing a suitable oscillating external magnetic field as a probe [20].
NMR parameters are considered as quantities which are determined shifts, indirect spin-spin coupling constant and direct dipole-dipole coupling constants. This electronic structure in turn confidentially interrelated to local and global geometry and hence internal flexibility and intramolecular interactions influences NMR parameters. Chemical shifts along with spin-spin coupling constants found an average experimentally in comparison to those values belonging to all geometrical arrangements arising throughout the sequence of NMR experiment. Unfortunately, chemical shifts are generally found to be dependent on the internal dynamics or on the intermolecular interactions in various descriptions. Consequently, for obtaining structural information, most experimental NMR techniques imply coupling constants or the nuclear Overhauser effect instead of chemical shifts. However, ab initio calculations provide the understanding to structure-chemical shifts or spin-spin coupling constant associations, which can make the experimental data interpretation much easier in this sense. That is the reason that highly capable and steadfast computational calculations are in high demand [21].
As commonly noted that, when results of sufficient quality are attainable by employing various strategies based on wave function properties. These procedures are restricted to small- and medium-sized systems unfortunately. With the advancements of density functional methods, it is possible to acquire pertinent results even for larger molecules, such as fragments of proteins and nucleic acids [22] where the electron correlation effects are indirectly accounted through the exchange-correlation functional. DFT-based NMR calculations have seen a rapid expansion during the last 10 years—that is perhaps best designated with the word explosion. Since the publication of these calculations, methods have already entered the standard repertoire of quantum chemistry in short time length. More comprehensive and technical as well as more general reviews are available as theoretical portrayal of NMR chemical shifts based on the more traditional ab initio procedures has seen a marvelous progress as well [23]. For NMR calculations, density functional theory (DFT) is recently proved to substitute the traditional Hartree-Fock (HF) and post-HF methods [24]. Inclusion of electron correlation effects in a very efficient way to calculate NMR parameters is a rather new field of application in DFT over the last years.
Total energy
In Eq. (11), the
The XC potential VXC is the functional derivative of the XC energy EXC with respect to the density, ρ. The inclusion of magnetic fields is another extension, which can be introduced. Obviously, this is essential to all the properties to be introduced. The magnetic field
where
Quality of the description centers exclusively on precision of the approximation to Exc as mentioned earlier that obvious form of the exchange-correlation functional (Exc) is not identified yet. Unfortunately, there is no systematic mode of improving exchange-correlation functionals although the pursuit for improved and better functionals is at the very core of DFT. Prevailing XC functionals can be roughly categorized into three distinct groups [28] as several approximations used for Exc are as follows:
The idea of a nonvariating electron gas laid the foundation of this model, which approximates Exc in turn written as:
The generalized gradient approximations (GGA) for Exc are not lone functions of local density ρ(r) but also functions of the gradient of charge density ∇ρ(r) in comparison to LDA. They can be generically inscribed as:
α and β denote to “up” and “down” spin, respectively, in Eq. (17). Now,
The GGA exchange functional’s representatives are functionals by Becke, 1988 (B or B88) [18] and by Perdew and Wang, 1986 (P or PW86) [29] and are the most familiar ones. Perdew and Wang also established the PW91 exchange-correlation functional [30] comprising exchange and correlation contributions; if used separately, both functionals are symbolized by PW91. The exchange fragment of PW91 is analogous to B88 and the correlation part is a modified form of P86. Currently, possibly the most prevalent correlation functional accounts to contributions of Lee et al. (LYP) [31]. Because of presence of some indigenous components, it differs from the other GGA functionals.
Exchange-correlation functionals in which exchange part is composed of particular Hartree-Fock exchange and pure density functionals for exchange are called hybrid functionals. These functionals consist of a mixture of Hartree-Fock exchange with DFT exchange and correlation in other words as depicted in Eq. (19).
An illustrative example of the above-mentioned hybrid representations is Becke’s three-parameter hybrid functional (B3), depicted in Eq. (20). [18], and exchange energy is being calculated by using this (B3) functional. If correlation functional LYP or PW91 is assumed for
B3LYP uses this formulation, with LYP for
The most basic DFT calculations of NMR chemical shifts were done years ago in which very small basis sets were employed and inappropriate approximation to the exchange-correlation (XC) functional was done due to which point of practical applicability was lost. Also in any handling of magnetic fields, another central exertion that surfaces is the so-called gauge problem [28] be it in DFT or otherwise.
The gauge requirement should disappear just as any anticipation value together with NMR possessions that can only hinge on the values of observable quantities. Certainly, this is the case for particular solutions of, for example, the KS equations, Eq. (12a, b) where large (immeasurable) basis sets are employed. A strong dependence on the choice of gauge is of main concern for approximate solutions with smaller (infinite) basis sets. Current applications of DFT for calculating NMR chemical shifts have used density functional theory individual gauge for localized orbitals (DFTIGLO) method [9] and gauge including atomic orbitals (GIAO) approach [32].
One appraises matrix fundamentals of the Hamiltonian in terms of a basis of field-dependent atomic orbitals (AO) in the GIAO method. By insertion of an intricate phase factor denoting the position of basis function, which is usually nucleus, the basic functions are made obviously dependent on the magnetic field. Such orbitals are termed as London atomic orbitals (LAO) or the gauge including atomic orbitals (GIAO). Matrix elements involved in GIAOs only differentiate in the vector potentials is the essence of idea, in that way entirely eradicating the reference to a complete gauge origin. Employment of field-dependent GIAOs as basic functions [33] is possibly the best solution to the gauge problem.
where
Working equations for the NMR shielding tensor (
where
where
The use of disseminated gauge origins was depicted by the individual gauge for localized orbitals method (IGLO) [9], which was the first to empower the organized learning of nuclear shielding in larger systems. Evaluation of shielding tensor in terms of localized molecular orbitals (MO) is the idea of approach. To minimalize the absolute value of paramagnetic involvement, individual gauge origins of shielding tensor are selected. In the IGLO method, local phase factors are involved to molecular orbital in comparison to the GIAO approach where a phase factor is associated to each atomic orbital. In computational analysis point of view, IGLO approach is less challenging in contrast to the GIAO method since the use of distinct approximations of derivative two-electron integrals by this approach is most probable. By using localized orbitals, previously mentioned approximations are empowered; hence, it is important to select an appropriate basis set in an IGLO calculation [35]. According to IGLO approach, it is possible to allot comparable exponential prefactors to other objects, e.g., to localized MOs as a replacement for GIAO method. In IGLO method, specific integrals are easier to estimate analytically. Gauge difficulty has been resolute recently by retaining numerical integration or by techniques that were used in geometry optimization measures.
Highly appropriate ab initio calculations of spin-spin coupling constants are still very infrequent and usually deal with the simplest molecules only in comparison to excessive advancement in concept and computer codes for shielding tensor scheming. Shielding tensors are the reasons behind sensitivity of nuclear spin spin coupling constants to the correlation effects and basis set quality [36]. There are four significant contributions which causes other problems to the nuclear spin-spin coupling constants, are enlisted as follows:
Fermi contact (FC),
Paramagnetic spin orbit (PSO)
Spin dipolar (SD)
Diamagnetic spin orbit (DSO)
HF calculations of the spin-spin coupling constants of large molecules lead to deprived contract with experimental numbers and further empirical scaling has to be done. On the other hand, the use of post–Hartree-Fock methods and prolonged basis sets for demanding handlings of all the four contributions is very inefficient and time-consuming.
In DFT, only a single paper by Fukui [23] published years ago was worthy initially, where the blend of finite perturbation theory (FPT) and the LCAO-Xa method was employed and only calculations of the FC contribution to the spin-spin coupling constant were carried out, which gave somewhat poor results likely as too poor basis set in combination with the Xa potential was used. As in Ref. [37], a new method to calculate the nuclear spin-spin coupling tensor using DFT procedure is developed sideways to the shielding tensor calculations in accordance. The portrayal of calculations follows Ref. [37]. By meaning, the nuclear spin-spin coupling tensor
The orientationally averaged value of the nuclear spin-spin coupling tensor (
Since calculations for TMS are encompassed in many software, DFT-B3LYP-GIAO is the 6-311 + G(2d.p) [38], a suitable basis set, which easily determines the chemical shifts relative to TMS. The use of smaller 6-31 + G(d,p) basis set for calculations is most suitable for students compared to larger basis sets such as the 6-311 + G(2d,p) or even the very large 6-311++G(3df,3pd) basis sets that are employed for research purposes on small molecules. Many of the movements necessitate much less than 3 hours fixed for a standard research laboratory session even while using the larger basic sets. First of all, in this method, the structure is optimized in all the cases, and then to establish that either optimized structure is at least a local minimal or not, vibrational frequencies are determined. After the complete optimization of the structure, shielding constants are calculated using the GIAO method. Calculations for chemical shifts are carried out by subtracting the value of the screening constant (σ), which is calculated from the value of the screening constant calculated for TMS using the same level of theory [38].
Basic considerations in NMR calculations are as follows: first, how many types of protons are there in molecule and which are they and second, how many NMR signals are expected to see and in which regions. In the case of an NMR spectrum calculation, geometry optimization calculation is needed first of all and then optimized structure is used to perform NMR spectrum calculation using the same method and basis set.
Follow the calculations in Section 2.1.5 till step i for geometry optimization calculations and then follow steps used to perform an HNMR spectrum calculation of the optimized structure with the same method and basis set.
Press the Calculate button in the Gauss View toolbar and select Gaussian. In the Job Type dialog box, select ‘NMR’ and ‘GIAO method. Submit the calculation after checking all parameters. Open the output file and select the NMR option from Results.
In the ‘SCF GIAO magnetic shielding dialog box, select ‘H’ option in Element drop-down list, and in the Reference list, select the calculation method earlier used. The number of peaks of magnetic shielding observed is noted. Infer calculated spectrum and compare it with theoretical calculations. With this, multiplicity of the peaks, temperature at which NMR experiment is simulated and width of the NMR peaks can be discussed.
Open the log file and search for or scroll to the line “SCF GIAO Magnetic Shielding tensor (ppm).” For simple NMR experiments, the signals are found at the chemical shifts, which appear after the heading “isotropic.” All other numbers relate to the directionality of the NMR signals.
As classic DFT is concerned with ground stationary state and applications, i.e., UV-vis spectroscopy, photochemistry, NLO and others, comprise either electronic excited states or time-dependent electronic characteristics, which are in agreement with time-dependent density functional theory (TD-DFT). From classic paper of Runge and Gross [39], formal TD-DFT is traced back, which strained to firm up former efforts on the same topic. Therefore, Runge-Gross TD-DFT is two decades younger than Hohenberg Kohn-Sham theory [2], which is about stationary ground state as mentioned earlier. Four theorems proposed in the Runge-Gross paper. First, Runge-Gross theorem states that external potential up to an additive function of time is regulated by time-dependent charge density,
Various chemical and physical molecular properties provide basis for electronic spectra. Different chemical and physical effects can easily be computationally investigated by modifying the spectral characteristics of molecules as many stimulating chemical problems are included in both ground and excited states of molecules. As for ground state properties of atoms, molecules and solids, DFT gave an effective explanation; hence, in order to designate photochemical and photophysical procedures, DFT formalism has to be expanded to excited states. So, for excited state calculations, time-dependent DFT (TD-DFT) is established as an operative tool [40] as it provides first principle technique for calculating excitation energies and various response-related characteristics in density functional outline.
There are classically one or more low energy excited states for a molecule that can be designated as valence-MO-valence-MO single electronic excitations and replicated in spectra. Energies of excited determinants are essential for multiplet energy calculation such as employing spin-orbital number (i) to the empty spin-orbital number (j). Accordingly, specific states are denoted as π → π*, n → π* transitions. Relative easiness of character sometimes smoothes the process of concluding wave functions for these states. The calculation of the dynamic answer of charge density proposes a rigorous direction to time-dependent simplification of DFT formalism. The poles of dynamic polarizability regulate excitation energies permitting the determination of electronic excitation spectrum in typical dipole approximation [41]. The poles’ strengths are provided by oscillator strengths (fi) or by transition dipole moment (μi) consistently also termed as intensity of the optical transitions.
Electronic absorption spectra calculation is foremost applicability of TD-DFT after the geometry got optimized by using linear response theory. First, the Hohenberg-Kohn theorem statement that dynamic linear response of a system of N-electrons is determined by the ground-state charge density was discussed earlier but no applied mean was found to build this response. A productive procedure was provided by TD-DFT from which absorption spectra can be calculated by following steps [42]:
where ωI and fI are corresponding vertical excitation energies and conforming oscillator strength.
Finally, spectrum was obtained employing Eq. (31) also termed as Lorentzian broadened stick spectrum:
Such a procedure has been executed in many computer codes, e.g., in Octopus code [43], and has benefited that absorption spectrum of a very huge molecule over a wide range of energies can be calculated even though using only reasonable spectral resolution. This function parallels to optical absorption spectrum, e.g., calculating spectra of benzene [44] by TD-DFT approach depicted in Figure 1.
Absorption spectra of benzene.
It is an important point to note that TD-DFT calculations not only give excitation energies (ω) but also provide respective oscillator strengths. Oscillator strengths are actually pure numbers in a complete basis set [42].
Obviously, ω = EI − E0 is an excitation energy in the case of |I〉〈0| and ω = E0 − EI is a de-excitation in the case of |0〉〈I|. To more simply relate the molar extinction coefficient (ε) in an absorption experimentation, Eq. (32) has been consciously expressed in Gaussian instead of atomic units. In SI units, frequency spectrum is assumed to first approximation [42] by:
where S(ν) is a spectral shape function usually a Gaussian whose full width at half maximal is determined through experiment with area normalized to unity, whereas NA depicts the Avogadro’s number.
Absorption spectrum frequently results by excitations having larger oscillator strength because absorption peaks are often scaled with oscillator strength (fI) of the excitation. Excitations with small oscillator strength (fI) are also omitted from final spectrum while fundamentally working on oscillator strength carrying subspace so that absorption spectrum is possibly calculated with less excitations in a fixed energy space. A common problem considered is that a large number of excitations have to be estimated with the purpose of covering energy space of concentration, while figure of absorption spectrum is determined by only some of them because of their greater oscillator strength (fI) [45].
Another detailed DFT method is presented, proposed in ref. [46], to calculate UV absorption spectra. The integration is completed over real
where
As high harmonic generation is possible with TD-DFT methods, emission spectra [48] are calculated by:
Absorption spectrum is the fundamental property of a system. One working on absorption spectra calculations is mainly concerned with the lowest excited states commonly. Though, excitations over a broader energy range may be essential, consequentially requiring very challenging calculations while working for large molecular complexes and high density of states (DOS) materials [49]. Hence, for large systems approximate, precise and efficient computational methods have to be looked for. LR-TD-DFT is extensively employed to compute absorption spectra of larger systems as well [50]. To estimate the absorption spectrum in full LR-TD-DFT context, a two-sided Lanczos process is proposed in Ref. [51]. To acquire an accurate estimation of absorption spectrum, a more standard Lanczos algorithm with an appropriately selected inner product was employed.
Density response of a system by applying an external time-dependent perturbation in linear response formulation of TD-DFT (LR-TD-DFT) is usually studied as [52]:
In chemistry, LR-TD-DFT equations are articulated in matrix arrangement using the Kohn-Sham basic formulation. First-order density response δρ(
In Fourier space, it is represented as:
The connection between Kohn-Sham response function and particular density response function is efficiently stated in terms of the inverse of their conforming Fourier transform time, t2 − t1 as follows:
In summary, locating excitation energies of the interacting system is problematic, and poles of the response function give the way to calculate excitation energies.
Actually, χ(ω) has poles at correct excitation energies ωI. From this point, calculations for absorption spectra follow the route as explained in Section 4.1. Computation of the dynamic dipole polarizability [α(ω)] is a noninteracting response of specific interest in calculating absorption spectra, which is a response function that relays external potential to the change in dipole as depicted in Section 4.1. The Fourier transform of the dynamic dipole polarizability can be written as in Eq. (29). Excitation energies (ωI) are calculated by poles of the dynamic polarizability [53], while the oscillator strengths are determined by residual (fI) [52].
Calculating the absorption spectrum with LR-TD-DFT method also includes resolving a non-Hermitian eigenvalue problem; therefore, the absorption spectrum is attained as [50]:
TD-DFT method in Gaussian makes it practical to study excited state systems since it produces results that are comparable in accuracy to ground-state DFT calculations. Natural transition orbitals (NTOs) can be a helpful way of obtaining a qualitative description of electronic excitations. They do so by transforming the ordinary orbital representation into a more compact particle (occupied) to empty hole (unoccupied) [54].
First step follows the calculations presented in Section 2.1.5 till step i for geometry optimization calculations and then follow steps used to perform TD-DFT calculation of the optimized structure for UV-Visible spectral calculations. Solvent can be added using TD (singlets, nstates).
Calculate the absorption spectrum. Compare the calculated absorption spectra (lambda max) with the experiment taking f > 0.0. Basis set/methods can be changed to generate spectrum in good agreement with theoretical assumption.
Generating NTOs:
Run an excited state calculation, saving the checkpoint file.
Examine the calculation results to determine the excited state of interest.
Run a single point calculation to generate the NTOs for the desired excited state. This step can be repeated to view focusing excited state.
In our work [55], we have synthesized 1,3-diisobutyl thiourea (C9H20N2S) and its vibrational analysis was carried out using DFT methods. Theoretical calculations for vibrational spectra analysis using DFT B3LYP/6–311G method were done in gaseous state, while experimental calculations were done in solid state. Geometry of compound was optimized using Gaussian employing DFT/B3LYP method with the 6–311G basis set. Optimized geometry of compound was compared with crystal structure of compound that depicted the support for the crystal structure (Figure 2). DFT results for vibrational analysis were compared with experimental analysis, which were found in good agreement with each other (Figure 3) [55].
Crystal structure (ORTEP plot) of 1,3-diisobutyl thiourea compound.
Comparative vibrational spectra of compound in gaseous state (theoretical, calculated using B3LYP/6–311G method) and in the solid state (experimental).
Sundaraganesun et al., calculated structure, harmonic frequencies and vibrational mode assignments for 2-chlorobenzoic acid using HF and DFT methods employing the 6-311++G(d,p) basis set. The results of the molecular structure and vibrational frequencies obtained on the basis of calculations in Gaussian are critically equated with experimental IR data recorded in gas phase (Figures 4 and 5) [56].
Numbering system implemented for 2-chlorobenzoic acid.
Graphic correlation between the experimental and calculated wavenumber obtained by the
Alver et al. carried out NMR spectroscopic study, and DFT calculations of GIAO NMR shieldings and 1J spin-spin coupling constants of 1,9-diaminononane (danon, C9H22N2) were done. 1H, 13C NMR chemical shifts and 1JCH coupling constants of danon are calculated by means of B3LYP method, and 6-311++G(d,p) basis set is used. Comparison between the experimental and the theoretical results illustrates that density functional B3LYP method is able to deliver suitable results for expecting NMR properties (Table 1, Figures 6 and 7) [57].
Nuclei | Experimental (ppm) | B3LYP (ppm) |
---|---|---|
C3, C7 | 28.2 | 31.1 |
C4, C6 | 30.5 | 34.6 |
C5 | 30.6 | 34.9 |
C2, C8 | 33.2 | 37.9 |
C1, C9 | 42.4 | 48.9 |
H16, 17, H24, 25 | 1.3 | 1.2 |
H18, 19, H22, 23, H20, 21 | 1.3 | 1.3 |
H30, 31, H32, 33 | 1.5 | 1.2 |
H14, 15, H26, 27 | 1.5 | 1.3 |
H12, 13, H28, 29 | 2.6 | 2.5 |
1J(CnHn) | Experimental (Hz) | B3LYP (Hz) |
---|---|---|
C2H14H15, C8H26H27 | 122.4 | 118.2 |
C3H16H17, C7H24H25 | 122.9 | 119.1 |
C4H18H19, C6H22H23 | 123.8 | 119.7 |
C5H20H21, C1H12H13, C9H28H29 | 135.2 | 132.1 |
Experimental and calculated 13C, 1H NMR chemical shifts (ppm) and 1JCH NMR coupling constants (Hz) of danon.
Optimized molecular structure of danon.
Plot of the calculated vs. the experimental 13C NMR chemical shifts (ppm) and 1J coupling constants (Hz) of danon.
This chapter focused on the use of DFT-based methods for spectral calculations, i.e., of vibrational, NMR and electronic calculations. Vibrational spectral generation depends upon Gaussian broadening function, while vibrational frequencies are calculated by determining the second derivative of energy after geometry optimization. Vibrational frequencies and zero-point energy for maximum vibration can be calculated theoretically as well. B3LYP density functional hybrid method is proposed to give more exact values of vibrational frequencies. The calculation of NMR parameters on DFT grounds depends upon exchange correlation functional, i.e., LDA, GGA and mostly employed hybrid functional B3LYP. The GIAO and IGLO methods are used to solving gauge problems in NMR shielding tensor calculations. Nuclear spin-spin coupling constants can be calculated on theoretical grounds, whereas DFT-B3LYP-GIAO method is employed for chemical shift calculations. For electronic spectral calculations, TD-DFT is employed for excited state measurements. Vertical excitations, oscillator strength and intensity of absorption are calculated using TD-DFT theoretical methods. Linear response function incorporation to TD-DFT approach has proved helpful to study electronic density and absorption spectrum calculations of larger systems. Gaussian software is most employed for IR, NMR and UV spectral calculations.
Racial or ethnic minorities (REM) in the United States (US) are particularly vulnerable to experiencing mental illness. The US Census Bureau describes the term “race” as people who identify as “White, Black or African American, American Indian or Alaska Native, Asian, Native Hawaiian or Other Pacific Islander, or Other Race” and ethnicity as “Hispanic or Latino or “Not Hispanic or Latino.” [1]. While REM report the lowest lifetime risk of mental illness and fewer psychological concerns as compared to non-Hispanic Whites, they are more likely to experience persistent illness [2]. For example, experiences of depression among Blacks and Hispanics are reported as lower than Whites, yet Blacks and Hispanics indicate more persistent symptomatology. In a 2020 screening for most prevalent mental health concerns of Americans (
Social determinants of health (e.g., health disparities, racial discrimination, racialized violence) exacerbate REM’s experiences of mental illness as well as their access to treatment and services [2, 3, 5, 7]. REM are also least likely to access culturally competent care and when they do seek the treatment they are improperly assessed, misdiagnosed, and receive poor care [6, 7, 8]. And thus, when REM seek treatment it is essential that counselors are culturally competent and use culturally appropriate interventions. Practitioners are trained and encouraged to utilize evidence-based treatments (EBTs), demonstrated in eliciting therapeutic change in providing care and treatment to their clients [9]. The cultural relevance of EBTs is debated and prescriptive clinical practice is criticized; some practitioners argue for more inclusive and culturally sensitive use of EBTs [10, 11]. Like most EBTs, the efficacy of mindfulness-based interventions has been investigated primarily on White people. Mindfulness-Based Stress Reduction (MBSR) is an evidence-based intervention shown to reduce stress for a few REM groups [12, 13]. A culturally adapted MBSR program has the potential to treat REM suffering from mental health conditions and improve quality of life.
REM are particularly vulnerable to experiencing mental health conditions. In the year 2020, about 331.4 million people live in the US and the racial or ethnic statistics show a composition where 61.6% identify as White, 18.7% as Hispanic or Latino/a, 12.4% as Black or African American, 10.2% as two or more races, 6% as Asian, 1.1% as American Indian/Alaska Native, and 0.2% as Native Hawaiian/Other Pacific Islander [1]. Though there are more people who identify as White than all REM groups combined, research suggests that REM are at a significantly higher risk of experiencing mental health conditions in part due to the impact of social determinants of health [8, 14].
The Hispanic or Latino population differs in ethnicity and culture, which makes this population unique. Skin tones vary considerably, and it is not uncommon for non-Hispanic or -Latino/a people to confuse someone of Hispanic descent, as being White American or African American. Because of the significant differences, it is important to understand that while all Hispanics may encounter mental health disparities some groups of Hispanics are affected at even greater rates than others. Overall little difference in the prevalence of mental health disorders exists between Hispanic or Latinos/as and non-Hispanic Whites. One major issue Hispanic children grapple with is suicidality. Hispanic youth are more likely to consider, plan, and attempt suicide than both Black and White youth [15]. However, when comparing Hispanics born in the US with Hispanics who identify as foreign-born, the data shows that US-born Hispanics experience mental health disorders more frequently [16]. As seen many times in the marginalized populations, Hispanics are not likely to seek therapy due to lack of access, resources, stigma, and discrimination and if they do seek therapy, it is often when their condition is at its worst [17, 18]. Instead of seeking treatment, Hispanics are more likely to adopt unhealthy coping behaviors (e.g., excessive alcohol consumption, poor eating habits, smoking, and illicit drugs), which affect the body negatively and can lead to serious and life-threatening medical conditions [18, 19].
Black or African Americans suffer from mental health conditions at about the same rate as Whites. However, they consistently are misdiagnosed and underexamined due to culturally incompetent practitioners, and thus left untreated [20]. In fact, Black or African Americans are less likely than White Americans to seek counseling or treatment and more likely to struggle including persistent emotional distress with feelings that life requires too much effort, worthlessness, hopelessness, and despair [21]. Furthermore, the report of somatic or physical complaints is common for Black people, as is, often failing to recognize that the underlying cause of their complaints is likely connected to an untreated or undiagnosed mental illness. Like Hispanics, Black or African Americans are not likely to seek treatment and when they do, the condition is severe or in crisis and may require intensive treatment (e.g., hospitalization) [6]. Only one in three Black or African Americans who need mental health treatment will obtain it. Undoubtedly, apprehension to seeking treatments likely influences the prevalence of depression that exists among Black or African Americans. For some, depression is accompanied by suicidal thoughts. As of 2019, the 2nd leading cause of death among Black or African Americans between ages 15 and 24 is suicide. Poverty is a social determinant that exacerbates the prevalence of mental illness and impacts access to treatment. For Black Americans, living below poverty increases the risk of experiencing serious psychological distress at three times a higher rate than when not living in poverty. Lastly, because Black or African Americans are relentless targets of violent crimes, discrimination, and racialized violence, the likelihood of developing a traumatic stress disorder is higher than the general population [21].
Asians are a diverse group that includes many distinct cultures, nationalities, diverse countries of origin, and mental health challenges. Asian Americans and Pacific Islanders comprise about 6.1% of the US population and of that nearly 15% reported experiencing a mental illness in the last year [22]. According to the American Psychological Association, Asian Americans are less prone than White Americans to seek help for any mental health or emotional concerns they experience [23]. Attempting and completing suicide is a prevalent issue within the Asian community and is identified as the 10th leading cause of death for Asian Americans. Women between the ages of 15 and 24 as well as 65 and older have the highest suicides rates across all racial and ethnic groups [24]. Asian Americans reported the increased vulnerability to mental health conditions are due to a range of factors including parental pressure to excel academically, discrimination, cultural attitudes as it relates to mental health care, difficulty with balancing cultures, and difficulty developing their sense of self while navigating multiple cultures [25]. Social determinants of health that exacerbate mental health conditions include discrimination, prejudice, racialized violence, problems related to immigration, cultural trauma, and model minority myth/stereotypes [22, 26]. Systemic barriers that serve as obstacles to treatment include misdiagnoses or under-diagnosing due to culturally incompetent practitioners, lack of multilingual services in healthcare, poor access to health insurance, and treatment costs [22, 26]. Because talking about mental health concerns are usually considered taboo, it is more likely for Asian American to seek support within their personal network.
Though American Indians and Alaskan Natives only make up 1.3% of the US population, over 19% indicated experiencing a mental health condition in the last year [27]. In fact, they report experiences of psychological distress at a rate of 1.5 times higher than all other racial groups. Historically, American Indians survived systemic trauma, such as forced relocation and family separation, death by way of war, and sickness and death due to exposure to infectious diseases, which likely impacts their mental health as well [28]. American Indians and Alaskan Natives have a substantially higher rate than the other racial or ethnic groups of experiencing post-traumatic stress disorder, suicide, substance use disorder, and attachment disorders [29]. Children and adolescents have the highest rates of suicidality as those between ages 15-19 have double the death rate than non-Hispanic Whites [27]. Furthermore, American Indians and Alaskan Natives use and abuse substances at younger ages and at higher rates than all other racial groups [7]. Major depression episodes and self-reported depression are three times higher than the US population. Additionally, American Indians and Alaskan Natives are still dealing with the consequences of past trauma and current detrimental policies as well as other social determinants, such as high poverty (e.g., 26.6% live in poverty), and other irreversible setbacks [27]. American Indians and Alaskan Natives are also twice as likely to experience unemployment their White counterparts. The cultural mistrust that exists is understandable yet has a negative effect on seeking mental health treatment, which in turn significantly increases the risk of mental illness. Systemic barriers that affect help-seeking include poverty rate, lack of access due to distance and language barriers, and lack of health insurances coverage [29].
Native Hawaiians and Pacific Islanders are yet another marginalized group that experienced historical trauma and are still coping as well as healing from the effects of the trauma today. The extent of the mental health disparity for this marginalized group is understudied, and thus, the prevalence of mental illness is a work in progress [26]. What is known is 10.1 % of Native Hawaiians and Pacific Islanders reported experiencing psychological distress as compared to 12.7% of non-Hispanic Whites. The leading cause of death between the ages of 15–24 among Native Hawaiians and Pacific Islanders was suicide in 2019 [30, 31]. Social determinants that exacerbate mental illness include multigenerational trauma, discrimination, poverty, housing inequities, and disparities in education and social capital [30, 31]. Like the other racial groups, there are several systemic barriers that exist to serve as an obstacle in receiving mental health treatment. One of the main barriers include the lack of access to care and health insurance [30]. In fact, Native Hawaiians and Pacific Islanders are three times less likely than non-Hispanic Whites to receive mental health services as well as prescriptions that treat psychological disorders. Although Native Hawaiian and Pacific Islanders do not report serious psychological distress at higher rates than Whites, male Native Hawaiian/Pacific Islanders between the ages of 25–44 report higher rates of death by suicide than White Americans [30].
Multiracial/Mixed Race populations are unique because they are most likely to struggle with identity development and feelings of ostracization, which directly affects their mental health [32, 33]. Adolescents who identify as multiracial or mixed are at a higher risk of suicide, substance use, and depression as compared to adolescents who identify with being in a single race or ethnic category [33, 34]. Additionally, mixed-race adolescents are at a higher risk than White adolescents of having overall poor mental health and to have significantly fewer protective factors [34]. The main social determinants that multiracial or mixed-raced people experience that exacerbates mental health include familial discrimination, racial discrimination, and racial identity invalidation [35].
Risk factors known to contribute to the prevalence and vulnerability of mental illness within REM communities are vast, and entail coping with significant life events, while simultaneously managing systemic barriers that are unique to their race. Examples of life events experienced by the majority include bereavement, a lack of access due to finances or distance, and poverty, while examples of unique systemic barriers include having minimal or inaccurate knowledge about mental health care, cultural mistrust, cultural attitudes towards mental health care, stigma, and lack of proper assessment and care due to multicultural incompetence, and social determinants (e.g., racial or ethnic discrimination, implicit bias, racialized violence, etc.) [14, 23, 36]. Common cultural barriers are discussed in the next section. As there is diversity among REM, there is also diversity in the risk factors that make these groups vulnerable to mental illness.
There are a variety of systemic barriers that REM minorities experience when seeking mental health treatment. A few common barriers are cultural mistrust, stigma, lack of access or knowledge of treatment, and financial difficulties [5, 37]. Cultural mistrust, also known as healthy cultural paranoia, refers to an inclination of distrust or skepticism that people of color have about White people when interacting within multiple contexts, such as education, healthcare, business, criminal justice system, etc [38]. The cultural mistrust that exists in communities of color stems from a history of racism, violence, and other social oppressions, which continue to inform US systems (e.g., medicine, education), industries (e.g., healthcare), and policies [38]. Even within the history of medical research, oppression was prevalent, such as the inhumane treatment conducted on REM minorities for the sake of medical advances. The US has a long history of marginalizing Black and Brown people for experimentation. In the 1840s, Dr. Marion Sims, “the father of gynecology” performed several surgeries on female slaves without anesthesia to better understand the female reproductive system [39].
Several historical studies revealed how the science and medical communities dissected and mutilated Black Americans and other ethnic minorities for decades under the guise of medical treatment and development. The Tuskegee Syphilis Experiment withheld antibiotics and without consent, which allowed the disease to run its course on groups of Black men serving as participants. During the 1970s, the University of Southern California-Los Angeles Medical Center sterilized Puerto Rican women by misinforming and forcing them into participation [39]. As a mechanism of scientific experimentation, REM developed a healthy skepticism about the true motive of White people in Western medicine and the intent of science, which continues to exist today [39]. As a result, REM attitudes toward seeking treatment for physical or mental health problems are informed by distrust, which in turn makes them reluctant to obtain help. As well, as racism and oppression continue to be embedded in US medical science, providers without cultural competence, humility, and sensitivity further marginalize REM through the improper assessment and treatment of REM. “Over 30% of Black people, 20% of Latinx people, and 23% of Indigenous people report avoiding medical care because of experiences of personal discrimination due to their race or ethnicity in health care settings” [40]. The fears of seeking help due to cultural insensitivity are transmitted across generations. Thus, cultural mistrust serves as a direct systemic barrier for REM’s decision-making about seeking treatment, which exacerbates mental illness in these communities.
When exploring the multidimensional nature of mental health stigma within communities of color, it is essential to exercise sensitivity and to understand that communicating intimate, familial issues to a stranger can feel like one is crossing cultural boundaries. Mental health stigma refers to derogatory or demeaning attitudes one has about mental illness; it is described as a) personal stigma, b) self-stigma (e.g., internalized attitudes), or c) institutional stigma (e.g., reflected in systemic or mainstream society) [41]. Cognitive processes, stereotypes, affective processes, prejudices, and behavioral processes, or discrimination inform one’s experience of stigma as the “stigmatizer” or the “stigmatized” [42]. There are differences in how mental health stigma affects REM and their mental health [42]. Among some Asian Americans, stigma may include upholding the “save face” mentality by not seeking psychological treatment to protect their family’s reputation [43]. Stigma may derive from individuals in their own community given the constant flow of misinformation about mental illnesses [41]. In some REM communities, people who choose to seek help may become the object of ridicule in their communities, which can lead to even more reluctance or apprehension to seek treatment [42]. To avoid shame and denial, some Black or African Americans may abuse substances as a means to cope with mental illness instead of seeking help [44]. In order to address the stigma that exists in these communities, there must be increased awareness and easier access to education about mental illness and mental healthcare.
There is a complex relationship between the utilization of mental health treatment and poverty-stricken neighborhoods [21, 27]. The adverse social conditions in certain geographic locations contribute to the vulnerability or manifestation of some psychological disorders [45]. As REM are more likely to reside in impoverished neighborhoods, they are more likely to lack accessibility to the education or resources needed to access psychological treatment [45]. Many Native Americans, for example, live in rural or isolated areas that do not offer the needed services, and transportation can be a deterrent to seeking treatment if one does not have a car or needs to spend a long time traveling to receive services [43]. Black or African Americans living in rural areas may believe there are better resources available in larger, more urban cities and may think the resources provided in their rural communities are either of poor quality or nonexistent [46].
Financial barriers play a considerable role in people’s reluctance to seek therapy. Some individuals are fearful they cannot afford mental health treatment and may never get help. While some REM lack the health insurance coverage necessary to see mental health professionals, others may have health insurance but may reside in a community where the majority of practitioners are self-pay only [47]. Due to a lower percentage of Latino/a with access to health insurance coverage, they are unable to financially afford mental health services [48]. As compared to their White counterparts, Black or African Americans and Latino/as earn lower incomes, receive less education, are least likely to have health insurance coverage, are more likely to be underinsured, and have a higher probability of being involved with the public- or social-service agencies [47]. And thus, each of these systemic barriers has an impact on the capacity to seek and obtain mental health services. These barriers need to be addressed on a systemic scale so that policy and funding can be allocated for the development of a mental health system that is inclusive and representative of all ethnic minorities.
In the US, nationwide health disparities and systemic barriers impede REM access to quality mental health services [49, 50]. REM are less likely to seek and engage in mental health services as compared to their White counterparts [49, 50, 51]. Additionally, those who opt to engage in mental health services believe that evidence-based is culturally appropriate, or report dissatisfaction from treatment engagement [49, 51, 52]. Evidence-based practices (EBPs) are defined as the combination of empirical research, clinical expertise, and the lived experiences, values, and identities of participants [9, 11, 53, 54]. Evidence-based treatments (EBTs) refer directly to the clinical interventions, supported by scientific research, that are implemented to promote positive therapeutic outcomes [9, 49, 53, 54]. EBTs are often utilized to treat anxiety disorders, depression, posttraumatic stress, trauma, chronic pain, eating disorders, and other mental health conditions [52, 55, 56, 57, 58, 59, 60]. Examples of clinical interventions include Cognitive Behavioral Therapy (CBT), Narrative Exposure Therapy (NET), Eye Movement Desensitization and Reprocessing (EMDR), and Cognitive Processing Therapy (CPT) [52, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69].
CBT is an empirically supported therapeutic treatment that is guided by the basic principle that exposing, challenging, and reshaping distorted thoughts, modifying behavioral patterns, and managing affective processes can increase positive coping skills and improve mental health [70]. Research demonstrates the effectiveness of CBT in the treatment of a variety of mental health conditions, to name a few: anxiety, depression, stress, substance use disorders, and chronic pain management with people throughout their lifespan [56, 71].
NET is a short-term, trauma-focused, therapeutic treatment that was originally developed for those experiencing trauma due to exposure to disaster, war, and torture [63, 72]. A significant component of NET is the perception that trauma is not an isolated event but is interwoven into an overlapping network of various traumas that contribute to distorted sensory and cognitive information and can lead to the development of posttraumatic stress [63, 72, 73]. NET assists individuals in processing these traumas through creating a narrative that chronologically maps traumatic events across their lifetime, rather than focusing on a single traumatic event [63, 73]. NET is effective in the treatment of posttraumatic stress disorder (PTSD), anxiety, depression, insomnia, and other trauma-related disorders [72, 73, 74, 75].
EMDR is an empirically supported therapeutic intervention that was developed in the late 1980’s when researcher, Francine Shapiro, observed that engaging in saccadic eye movements, while recalling traumatic memories, significantly reduced the intensity of anxiety associated with these disturbing thoughts [65, 76]. EMDR is proven to be effective in mitigating the impact of traumatic stress, anxiety, and depression through aiding participants in processing dysfunctional memories and developing more adaptive cognitive processes [52, 66, 76, 77, 78].
CPT is an evidence-based cognitive therapy that is commonly utilized to treat PTSD [79]. CPT provides participants with psychoeducation about trauma, stress, and cognitive skill-building to aid in the identification of “stuck points” that form distorted thought processes that contribute to symptoms of posttraumatic stress [79, 80].
Despite widespread acceptance in the treatment of trauma and other mental health conditions, EBTs are often critiqued for a lack of cultural relevance [11, 81]. Historically, REM have been underrepresented in the scientific research that informs the efficacy of these interventions [49, 53, 54, 82, 83]. Researchers believe that this underrepresentation compromises the efficacy of these treatments among minority populations, and may negatively influence participant engagement, outcomes, and treatment satisfaction [49, 53]. Researchers investigate and address this disparity through the implementation of culturally competent programmatic modifications to traditional EBTs [52, 60, 79, 84, 85]. And thus, it is essential that practitioners be conscientious of cultural factors that inform REM perceptions of mental illness, the nature of their presenting concerns, and their desire or propensity to seek help; the EBTs that are utilized will not account for or address the nuances these individuals experience.
In one empirical study, researchers modified CBT interventions to be culturally inclusive for Mexican American women struggling with binge eating disorders. Findings suggested the eating habits of Latina women were significantly affected by both the cultural meaning of food and cultural beliefs surrounding help-seeking behaviors [60]. The women were less likely to be motivated by thinness ideals than their White counterparts and were more likely to engage in binge eating behaviors due to food signifying love, community, and other factors of their culture. In other words, the Latinas’ experiences were informed by cultural beliefs that implied they should be considerate of others before caring for themselves, which made them less likely to engage in treatment for their eating disorders [60]. Adaptations for the CBT intervention included guiding participants in navigating culturally specific social interactions about food, assisting participants in navigating culturally relevant healthy food options, and advocating for culturally competent service delivery.
Furthermore, it is necessary to implement cultural modifications to meet the unique needs of specific populations, such as refugee survivors [64]. Another common EBT, NET, is often used with diverse populations, such as refugees who experience trauma by exposure to war, torture, political unrest, anxiety, and depression [63, 64, 74, 75]. In another investigation of the cultural appropriateness of EBTs, NET was empirically examined and modified to address the specific needs of Cambodian survivors. The research adapted a NET intervention to meet the needs of Cambodian survivors of the Khmer Rouge genocide [86]. The adaptation included the implementation of traditional spiritual practices, such as chanting, protection rituals, and the presence of Buddhist monks to supplement the traditional NET intervention format [86]. The participants were responsive to this treatment approach.
It is common for some investigators to examine the efficacy of traditional EBTs on specific minoritized populations. For example, one study attempted to examine the efficacy of a traditional EMDR intervention with Black or African American clients [52]. Several themes emerged that inform future adaptions to EMDR as an efficacious intervention for Black or African American clients. More specifically, the findings indicated the participants had insufficient psychoeducation on EMDR, which contributed to fear, uncertainty, and feelings of powerlessness regarding participation in the intervention. Additionally, the participants lacked trust and felt they were unable to identify with the White treatment providers who administered the intervention [52]. Combine these findings with Black or African Americans’ experience of systemic barriers; not only will they be less likely to seek treatment, but also their mental health conditions will deteriorate. An example of a study where researchers made cultural adjustments to an EMDR intervention to meet the needs of Syrian refugees includes implementing a translation of program materials into the local language, adjusting to a scheduled time (preferred evening schedules), and providing a discreet location for intervention services to decrease the possibility of stigmatization for receiving mental health services [55].
Spanish-speaking Latino populations face unique barriers when treated with EBTs. Shortages of Spanish-speaking clinicians, lack of access to bilingual program material, and limited protocol about culturally appropriate adaptations to EBTs are examples of unique barriers that Spanish-speaking Latino populations experience that can exacerbate their mental health or deter them from seeking help [85]. When seeking to culturally adapt a CPT intervention to meet the needs of Spanish-speaking Latinos managing PTSD, one study found that participants reported a lack of language accessibility of materials, difficulty understanding psychological terms, and poor integration of cultural values in program materials to be challenging [85]. Findings from a similar empirical study identified comparable barriers when adapting a CPT intervention for Native American women diagnosed with Human Immunodeficiency Virus (HIV), PTSD, and who were engaged in high-risk sexual activities [87]. These barriers included difficulty understanding scientific language presented in program materials as well as lack of spiritual and cultural relevance. Another CPT intervention was modified to address the needs of Kurdish trauma survivors living in Iraq [84]. Adaptations to the CPT manual and materials included the removal of American cultural idioms, reduction of psychological terms, translation of materials into Kurdish language, adjustment of language to create greater accessibility across literacy levels, and implementation of culturally appropriate case examples.
Today, researchers advocate for more culturally competent clinicians and propose cultural modifications to EBTs to help improve outcomes for REM who are participants in these interventions [52, 57]. As well, more REM need to be invited to participate in clinical trials when examining the efficacy of EBTs. Challenging clinicians to be creative in their clinical work, such as using clinical tools like the Multidimensional Model for Developing Cultural Competence (MMDCC) to guide practice can also improve psychological outcomes for REM clients [88]. The components of the MMDCC include cultural awareness, cultural knowledge, cultural knowledge of behavioral health, and cultural skill development and the components examine how these factors intersect at the individual, clinical, and organizational levels. Additionally, adaptations of intervention language are widely accepted as a culturally competent adjustment to EBPs [89]. There is presently no universal protocol for the culturally competent modification of EBTs [57, 89].
MBSR was originally developed to reduce psychological and emotional stressors experienced by people with chronic health issues [12, 90]. MBSR has been administered to a wide range of populations in different settings, such as hospitals, schools, and prisons [90]. An advantage of MBSR is its format as a group training program that are led by either one or two trained instructors who facilitate group sessions [91, 92]. In order for MBSR to be most effective, instructors should have competency in teaching the program, embody qualities of mindfulness, commit to good practice, and be engaged in the learning process [90].
For participants, a potential benefit of MBSR is the shared experience of addressing various psychosocial stressors in a supportive group setting. Specifically, MBSR is administered as an 8 to 10-week training program intended to reduce stress through the systematic application of mindful-based practices [12, 91, 92]. Groups can range from 10 to 40 participants who meet weekly for a 2.5 hour MBSR training session. Activities for each session often include mindfulness meditation, mindful awareness, yoga, and mindfulness practice for stressful events [12, 92]. As a requirement of MBSR, participants are assigned a 45-minute homework task. These daily homework assignments include practicing different mindful-based exercises learned in each session. Mindfulness is developed through regular and repeated practice, which helps people readily access the techniques during stressful events [92].
The application of MBSR is an effective non-pharmacological method toward managing stress deriving from chronic physical illnesses (e.g., cancer, diabetes, hypertension, HIV) [93]. In fact, studies found that the practice of MBSR enhances coping skills while being used as an alternative medical treatment for clinical patients [92, 93]. For treatment of physical health conditions, reportedly MBSR decreases patient complaints of sensory pain, physical impairment, and medical symptoms. Furthermore, even non-clinical populations indicate improved quality of life after participating in MBSR [12, 92]. Overall, empirical findings suggest that MBSR can be utilized as a healthy coping strategy to manage a range of physical ailments.
In terms of mental health treatment, MBSR is found to be an effective approach in reducing symptoms related to anxiety disorders (e.g., generalized anxiety, social anxiety, panic attacks); more specifically, symptoms that relate to worrying and future-oriented cognitions [94, 95]. Furthermore, individuals with anxiety disorders report improvements in transdiagnostic symptoms (e.g., emotion dysregulation, avoidance, cognition) after completing a course of MBSR [94]. These participants indicated that MBSR was a beneficial activity to reduce their anxiety, helped them feel at ease, and gave them the confidence to do more activities. Based on these findings, MBSR is a clinical intervention that can be utilized to guide individuals toward change and acceptance of their anxiety [94].
Although, the clinical efficacy of MBSR extends beyond the treatment of various anxiety disorders and physical ailments. Among both clinical and non-clinical groups, MBSR has been found to be moderately effective at reducing depressive symptoms and psychological distress [12, 92, 96]. Moreover, MBSR is shown to decrease depressive symptoms and slightly improved cognitions among individuals with mild cognitive impairment. These results indicate that MBSR can be used as a supplemental treatment for mild to moderate depressive disorders [96].
Additionally, the effectiveness of MBSR as an alternative treatment for clinical ailments may be attributed to neurological change. In one study, neuroimaging data indicated increased connectivity in the visual and auditory networks of participants who completed an 8-week course of MBSR [97]. Likewise, the increased neurological connectivity was associated with improved attentional focus, sensory processing, and awareness of sensory experiences [97]. Similar neuroimaging studies found increased connectivity in the hippocampal region of participants after completing MBSR [98]. As a result, the findings suggested increased hippocampal connectivity from mindfulness may improve stress resilience and fear extinction (e.g., worry) [98]. And thus, MBSR as a clinical treatment promotes beneficial neurological growth and regeneration, which positively affects physical and mental health outcomes.
The efficacy of MBSR as an EBT for physical and mental health conditions is well documented. However, there is a dearth of research that promotes mindfulness-based interventions as a treatment for REM populations. There are a few studies that demonstrate MBSR as a potential culturally appropriate treatment for a wide range of clinical ailments. For example, Native American, Latinx, and Black communities often uphold values that honor the mind-body and spiritual connection. Mindfulness-based techniques are inclusive of historical, social, and cultural perspectives or ideologies, which align with the needs of REM communities. And thus, the mindfulness-based interventions can promote communal coping (e.g., community or collectively) and healing (e.g., prayer, meditation, other spiritual rituals) [99].
In another example, MBSR can serve to reduce health disparities for Black or African American females experiencing the stress or traumatic stress deriving from sexism and racism [100]. In turn, MBSR can help Black women overcome harmful cultural or racialized stereotypes such as the Superwoman schema and the Strong Black woman script. A recent investigation found that prediabetic Black or African Americans notable decreases in diabetes risk (i.e., lower A1C) after completing an MBSR program [13]. These participants reported increases in spiritual well-being and reductions in perceived stress, BMI, and fat. These studies indicate that MBSR served as a culturally appropriate treatment for African Americans experiencing psychosocial stressors.
The benefits of mindfulness-based interventions (MBI) such as MBSR and mindfulness-based cognitive therapy (MBCT) have also been examined for REM and age demographics. A recent study found that culturally adapted mindfulness-based interventions for Latinx populations were correlated with improvements in depression, stress, and chronic illness [101]. Similarly, MBSR and MBCT were found to reduce depressive and anxiety symptoms among various Asian communities [102]. After participating in MBSR, low-income older African Americans reported decreased stress, depression, and anger and decreased blood pressure [103, 104]. Findings also indicated that young African Americans with HIV that completed MBSR experienced decreased hostility and improvements in social relationships, academic achievement, and physical health [105]. Thus, there is evidence that mindfulness-based interventions are culturally sensitive and inclusive, which aligns with the needs of REM coping with mental health conditions.
REM are at a particularly high risk of experiencing mental health conditions. Social determinants of health, such as poverty, racialized violence, or discrimination exacerbate REM mental health and quality of life. REM are less likely than White people to seek and receive treatment. Furthermore, REM are more likely to experience systemic barriers, such as cultural mistrust, mental health stigma, lack of access, and lack of financial resources, further complicating their willingness and capacity to seek treatment. While EBTs are identified as empirically supportive to treatments for a range of mental health conditions, there is skepticism about their cultural appropriateness and relevance for REM populations. Clinicians must be culturally competent and use clinical tools (e.g., Multidimensional Model for Developing Cultural Competence) to assist in promoting cultural competence. Practitioners must be conscientious and knowledgeable about the pitfalls of EBTs when working with REM. Mindfulness-based techniques, such as MBSR, are culturally sensitive and inclusive of historical, social, and cultural ideologies that align with the needs of REM. MBSR has the potential to offer holistic coping given its effectiveness in promoting neurological, physical, and psychological healing.
There are no acknowledgments to disclose for this work.
There are no conflicts of interest pertaining to the authors to report or special circumstances for this work.
Thank you to all the authors who came together to get our message out. I would like to express my sincerest gratitude to the students who helped me.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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by",editors:[{id:"7153",title:"Prof.",name:"Gustavo",middleName:null,surname:"Morari Do Nascimento",slug:"gustavo-morari-do-nascimento",fullName:"Gustavo Morari Do Nascimento"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2328",title:"Clay Minerals in Nature",subtitle:"Their Characterization, Modification and Application",isOpenForSubmission:!1,hash:"112c3a1f61e5fe575b0a49a9013ebe88",slug:"clay-minerals-in-nature-their-characterization-modification-and-application",bookSignature:"Marta Valaškova and Gražyna Simha Martynkova",coverURL:"https://cdn.intechopen.com/books/images_new/2328.jpg",editedByType:"Edited by",editors:[{id:"128173",title:"Dr.",name:"Marta",middleName:null,surname:"Valaskova",slug:"marta-valaskova",fullName:"Marta 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With an increasing understanding of clay structure, montmorillonite is realized viable for an enhanced performance in a variety of materials and products in the areas of catalysis, food additive, antibacterial function, polymer, sorbent, etc. Significant development in the use and application of montmorillonite is seen in recent time. This chapter provides an overview of montmorillonite, structure, and properties and particularly discusses its recent utilization in important materials. Montmorillonite is introduced in terms of its natural sources, chemical structure, physical and chemical properties, and functional utilization. The important physical and chemical properties are summarized as particle and layered structure, molecular structure and cation exchange effect, barrier property, and water sorption. This is followed by the important functional utilizations of montmorillonite based on the effects of its chemical structure. The important functional utilization of montmorillonite includes food additive for health and stamina, for antibacterial activity against tooth and gum decay, as sorbent for nonionic, anionic, and cationic dyes, and the use as catalyst in organic synthesis. The environment concerns, to date, do not indicate the adversity for particles used as additive. Studies will be useful which are clearly based on any montmorillonite structure to describe environmental effects.",book:{id:"6561",slug:"current-topics-in-the-utilization-of-clay-in-industrial-and-medical-applications",title:"Current Topics in the Utilization of Clay in Industrial and Medical Applications",fullTitle:"Current Topics in the Utilization of Clay in Industrial and Medical Applications"},signatures:"Faheem Uddin",authors:[{id:"228107",title:"Prof.",name:"Faheem",middleName:null,surname:"Uddin",slug:"faheem-uddin",fullName:"Faheem Uddin"}]},{id:"38850",doi:"10.5772/47790",title:"Clay Minerals from the Perspective of Oil and Gas Exploration",slug:"clay-minerals-from-the-perspective-of-oil-and-gas-exploration",totalDownloads:16109,totalCrossrefCites:18,totalDimensionsCites:45,abstract:null,book:{id:"2328",slug:"clay-minerals-in-nature-their-characterization-modification-and-application",title:"Clay Minerals in Nature",fullTitle:"Clay Minerals in Nature - Their Characterization, Modification and Application"},signatures:"Shu Jiang",authors:[{id:"138867",title:"Dr.",name:"Shu",middleName:null,surname:"Jiang",slug:"shu-jiang",fullName:"Shu Jiang"}]},{id:"38859",doi:"10.5772/51237",title:"Vermiculite: Structural Properties and Examples of the Use",slug:"vermiculite-structural-properties-and-examples-of-the-use",totalDownloads:4803,totalCrossrefCites:8,totalDimensionsCites:44,abstract:null,book:{id:"2328",slug:"clay-minerals-in-nature-their-characterization-modification-and-application",title:"Clay Minerals in Nature",fullTitle:"Clay Minerals in Nature - Their Characterization, Modification and Application"},signatures:"Marta Valášková and Gražyna Simha Martynková",authors:[{id:"128173",title:"Dr.",name:"Marta",middleName:null,surname:"Valaskova",slug:"marta-valaskova",fullName:"Marta Valaskova"}]},{id:"38858",doi:"10.5772/50172",title:"Role of Clay Minerals in Chemical Evolution and the Origins of Life",slug:"role-of-clay-minerals-in-chemical-evolution-and-the-origin-of-life",totalDownloads:4774,totalCrossrefCites:19,totalDimensionsCites:34,abstract:null,book:{id:"2328",slug:"clay-minerals-in-nature-their-characterization-modification-and-application",title:"Clay Minerals in Nature",fullTitle:"Clay Minerals in Nature - Their Characterization, Modification and Application"},signatures:"Hideo Hashizume",authors:[{id:"142318",title:"Dr.",name:"Hideo",middleName:null,surname:"Hashizume",slug:"hideo-hashizume",fullName:"Hideo Hashizume"}]},{id:"49766",doi:"10.5772/62082",title:"Charging Behavior of Clays and Clay Minerals in Aqueous Electrolyte Solutions — Experimental Methods for Measuring the Charge and Interpreting the Results",slug:"charging-behavior-of-clays-and-clay-minerals-in-aqueous-electrolyte-solutions-experimental-methods-f",totalDownloads:3140,totalCrossrefCites:9,totalDimensionsCites:20,abstract:"We discuss the charging behavior of clays and clay minerals in aqueous electrolyte solutions. Clay platelets exhibit different charging mechanisms on the various surfaces they expose to the solution. Thus, the basal planes have a permanent charge that is typically considered to be independent of pH, whereas the edge surfaces exhibit the amphoteric behavior and pH-dependent charge that is typical of oxide minerals. Background electrolyte concentration and composition may affect these two different mechanisms of charging in different ways. To guide and to make use of these unique properties in technical application, it is necessary to understand the effects of the various master variables (i.e. pH and background salt composition and concentration). However, how to disentangle the various contributions to the charge that is macroscopically measurable via conventional approaches (i.e. electrokinetics, potentiometric titrations, etc.) remains a challenge. The problem is depicted by discussing in detail the literature data on kaolinite obtained with crystal face specificity. Some results from similar experiments on related substrates are also discussed. As an illustration of the complexity, we have carried out extensive potentiometric mass and electrolyte titrations on artificial clay samples (Na-, Ca-, and Mg-montmorillonite). A wide variety of salts was used, and it was found that the different electrolytes had different effects on the end point of mass titrations. In the case of a purified sample (i.e. no acid-base impurities), the end point of a mass titration (the plateau of pH achieved for the highest concentrations of solid), in principle, corresponds to the point of zero net proton and hydroxide consumption, at which in ideal systems, such as oxide minerals, the net proton surface charge density is zero. To such concentrated (dense) suspensions of clay particles, aliquots of salts can be added and the resulting pH indicates the specificity of a given salt for a given clay particle system. In the experimental data, some ambiguity remains, which calls for further detailed and comprehensive studies involving the application of all the available techniques to one system. Although, right now, the overall picture appears to be clear from a generic point of view (i.e. concerning the trends), clearly, in a quantitative sense, huge differences occur for nominally identical systems and only such a comprehensive study will allow to proof the current phenomenological picture and allow the next step to be taken to understand the fine details of the complex clay-electrolyte solution interfaces.",book:{id:"5073",slug:"clays-clay-minerals-and-ceramic-materials-based-on-clay-minerals",title:"Clays, Clay Minerals and Ceramic Materials Based on Clay Minerals",fullTitle:"Clays, Clay Minerals and Ceramic Materials Based on Clay Minerals"},signatures:"Tajana Preocanin, Ahmed Abdelmonem, Gilles Montavon and\nJohannes Luetzenkirchen",authors:[{id:"111676",title:"Prof.",name:"Tajana",middleName:null,surname:"Preocanin",slug:"tajana-preocanin",fullName:"Tajana Preocanin"},{id:"176270",title:"Dr.",name:"Johannes",middleName:null,surname:"Luetzenkirchen",slug:"johannes-luetzenkirchen",fullName:"Johannes Luetzenkirchen"},{id:"180461",title:"Dr.",name:"Ahmed",middleName:null,surname:"Abdelmonem",slug:"ahmed-abdelmonem",fullName:"Ahmed Abdelmonem"},{id:"180462",title:"Dr.",name:"Gilles",middleName:null,surname:"Montavon",slug:"gilles-montavon",fullName:"Gilles Montavon"}]}],mostDownloadedChaptersLast30Days:[{id:"60931",title:"The Importance of Clay in Geotechnical Engineering",slug:"the-importance-of-clay-in-geotechnical-engineering",totalDownloads:5282,totalCrossrefCites:8,totalDimensionsCites:11,abstract:"Clay is a very important material in geotechnical engineering, because it is often observed in geotechnical engineering practice. Generally, this soil type has numerous problems due to its low strength, high compressibility and high level of volumetric changes. Clay needs to be improved before it can be used in road construction, dams, slurry walls, airports and waste landfills. Improved gradation, a reduction in plasticity and swelling potential, as well as an increase in strength and workability, generally improve the stability of clay. Clay is a fine-grained soil, but not all fine-grained soils are clay. Clay minerals are very electrochemically active; thus, they affect soil microstructures. Due to these characteristics, many important soil problems related to clay have been observed in the past, the importance of which is understood. In this chapter, the properties of clay, as well as the use of clay in geotechnical engineering and geotechnical studies on clay, are examined.",book:{id:"6561",slug:"current-topics-in-the-utilization-of-clay-in-industrial-and-medical-applications",title:"Current Topics in the Utilization of Clay in Industrial and Medical Applications",fullTitle:"Current Topics in the Utilization of Clay in Industrial and Medical Applications"},signatures:"Nazile Ural",authors:[{id:"227767",title:"Associate Prof.",name:"Nazile",middleName:null,surname:"Ural",slug:"nazile-ural",fullName:"Nazile Ural"}]},{id:"61845",title:"Montmorillonite: An Introduction to Properties and Utilization",slug:"montmorillonite-an-introduction-to-properties-and-utilization",totalDownloads:5506,totalCrossrefCites:44,totalDimensionsCites:78,abstract:"Clay mineral is an important material available in nature. With an increasing understanding of clay structure, montmorillonite is realized viable for an enhanced performance in a variety of materials and products in the areas of catalysis, food additive, antibacterial function, polymer, sorbent, etc. Significant development in the use and application of montmorillonite is seen in recent time. This chapter provides an overview of montmorillonite, structure, and properties and particularly discusses its recent utilization in important materials. Montmorillonite is introduced in terms of its natural sources, chemical structure, physical and chemical properties, and functional utilization. The important physical and chemical properties are summarized as particle and layered structure, molecular structure and cation exchange effect, barrier property, and water sorption. This is followed by the important functional utilizations of montmorillonite based on the effects of its chemical structure. The important functional utilization of montmorillonite includes food additive for health and stamina, for antibacterial activity against tooth and gum decay, as sorbent for nonionic, anionic, and cationic dyes, and the use as catalyst in organic synthesis. The environment concerns, to date, do not indicate the adversity for particles used as additive. Studies will be useful which are clearly based on any montmorillonite structure to describe environmental effects.",book:{id:"6561",slug:"current-topics-in-the-utilization-of-clay-in-industrial-and-medical-applications",title:"Current Topics in the Utilization of Clay in Industrial and Medical Applications",fullTitle:"Current Topics in the Utilization of Clay in Industrial and Medical Applications"},signatures:"Faheem Uddin",authors:[{id:"228107",title:"Prof.",name:"Faheem",middleName:null,surname:"Uddin",slug:"faheem-uddin",fullName:"Faheem Uddin"}]},{id:"49271",title:"Ceramic Materials Based on Clay Minerals in Cultural Heritage Study",slug:"ceramic-materials-based-on-clay-minerals-in-cultural-heritage-study",totalDownloads:3187,totalCrossrefCites:5,totalDimensionsCites:9,abstract:"The artifacts belonging to the ceramic heritage are mostly based on all clay types used by humans over the ages, because the sources of clays were easily available and people were interested to produce ceramics and pottery. This is the reason why the conservation of cultural heritage is of great concern. Ceramics (Greek κεράμιον Keramion) is a material obtained by shaping and firing clay. In the Romanian history, many ceramic pieces, of great diversity, have been discovered, and most of them are used in traditional households. Ceramic materials based on clay minerals in cultural heritage (ceramic heritage) involve techniques of characterization of raw materials and ceramic objects based on clays, discovered in different archaeological sites, leading to some results about the production technology, provenance, authentication, and historical appartenance on Romanian territory. The chemical composition of ancient ceramics and pigments decorating them, excavated from different Romanian archaeological sites, suggested a chemical composition of ceramic based on clay minerals (kaolinite, illite, and smectite), while the pigments belonging to them contained red pigments (hematite or ocher), manganese oxides (brown pigments), and magnetite or carbon of vegetable origin (black-pigmented layers).",book:{id:"5073",slug:"clays-clay-minerals-and-ceramic-materials-based-on-clay-minerals",title:"Clays, Clay Minerals and Ceramic Materials Based on Clay Minerals",fullTitle:"Clays, Clay Minerals and Ceramic Materials Based on Clay Minerals"},signatures:"Rodica-Mariana Ion, Radu-Claudiu Fierăscu, Sofia Teodorescu, Irina\nFierăscu, Ioana-Raluca Bunghez, Daniela Ţurcanu-Caruţiu and\nMihaela-Lucia Ion",authors:[{id:"137269",title:"Dr.",name:"Radu Claudiu",middleName:null,surname:"Fierascu",slug:"radu-claudiu-fierascu",fullName:"Radu Claudiu Fierascu"},{id:"171504",title:"Prof.",name:"Rodica-Mariana",middleName:null,surname:"Ion",slug:"rodica-mariana-ion",fullName:"Rodica-Mariana Ion"},{id:"176479",title:"Dr.",name:"Sofia",middleName:null,surname:"Teodorescu",slug:"sofia-teodorescu",fullName:"Sofia Teodorescu"},{id:"176480",title:"Dr.",name:"Irina",middleName:null,surname:"Fierascu",slug:"irina-fierascu",fullName:"Irina Fierascu"},{id:"176481",title:"Dr.",name:"Ioana Raluca",middleName:null,surname:"Bunghez",slug:"ioana-raluca-bunghez",fullName:"Ioana Raluca Bunghez"},{id:"176482",title:"Prof.",name:"Daniela",middleName:null,surname:"Turcanu-Carutiu",slug:"daniela-turcanu-carutiu",fullName:"Daniela Turcanu-Carutiu"},{id:"176483",title:"Dr.",name:"Mihaela-Lucia",middleName:null,surname:"Ion",slug:"mihaela-lucia-ion",fullName:"Mihaela-Lucia Ion"}]},{id:"62742",title:"Development of Clay Nanoparticles Toward Bio and Medical Applications",slug:"development-of-clay-nanoparticles-toward-bio-and-medical-applications",totalDownloads:1963,totalCrossrefCites:8,totalDimensionsCites:14,abstract:"Clay nanoparticles are among the most applicable and cost-affordable materials, all of which have a variety of applications in case of medical science. In this chapter, key characteristics of the clay nanoparticles along with their major groups, structure, morphology, and physicochemical properties were evaluated. Thereafter, the applications of clay nanoparticles in the field of nanocomposite, polymeric matrices, and medicine were investigated, while specimen production procedures were also reviewed. The main focus of this chapter is to investigate the applications of clay nanoparticles in bio- and medical science. In fact, organically modified clay nanoparticles (organoclays) are an attractive class of hybrid organic–inorganic nanomaterials with potential applications in case of polymer nanocomposites, rheological properties modification, and drug delivery carrier.",book:{id:"6561",slug:"current-topics-in-the-utilization-of-clay-in-industrial-and-medical-applications",title:"Current Topics in the Utilization of Clay in Industrial and Medical Applications",fullTitle:"Current Topics in the Utilization of Clay in Industrial and Medical Applications"},signatures:"Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Sarvenaz Salahi,\nMojgan Hosseini, Ali Mohammad Amani and Aziz Babapoor",authors:[{id:"208535",title:"M.Sc.",name:"Seyyed Alireza",middleName:null,surname:"Hashemi",slug:"seyyed-alireza-hashemi",fullName:"Seyyed Alireza Hashemi"},{id:"217960",title:"Mr.",name:"Seyyed Mojtaba",middleName:null,surname:"Mousavi",slug:"seyyed-mojtaba-mousavi",fullName:"Seyyed Mojtaba Mousavi"},{id:"217961",title:"Dr.",name:"Ali Mohammad",middleName:null,surname:"Amani",slug:"ali-mohammad-amani",fullName:"Ali Mohammad Amani"}]},{id:"38850",title:"Clay Minerals from the Perspective of Oil and Gas Exploration",slug:"clay-minerals-from-the-perspective-of-oil-and-gas-exploration",totalDownloads:16117,totalCrossrefCites:18,totalDimensionsCites:45,abstract:null,book:{id:"2328",slug:"clay-minerals-in-nature-their-characterization-modification-and-application",title:"Clay Minerals in Nature",fullTitle:"Clay Minerals in Nature - Their Characterization, Modification and Application"},signatures:"Shu Jiang",authors:[{id:"138867",title:"Dr.",name:"Shu",middleName:null,surname:"Jiang",slug:"shu-jiang",fullName:"Shu Jiang"}]}],onlineFirstChaptersFilter:{topicId:"669",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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",coverUrl:"https://cdn.intechopen.com/series/covers/23.jpg",latestPublicationDate:"August 1st, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"280770",title:"Dr.",name:"Katherine K.M.",middleName:null,surname:"Stavropoulos",slug:"katherine-k.m.-stavropoulos",fullName:"Katherine K.M. Stavropoulos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRdFuQAK/Profile_Picture_2022-05-24T09:03:48.jpg",biography:"Katherine Stavropoulos received her BA in Psychology from Trinity College, in Connecticut, USA and her Ph.D. in Experimental Psychology from the University of California, San Diego. She completed her postdoctoral work at the Yale Child Study Center with Dr. James McPartland. Dr. Stavropoulos’ doctoral dissertation explored neural correlates of reward anticipation to social versus nonsocial stimuli in children with and without autism spectrum disorders (ASD). She has been a faculty member at the University of California, Riverside in the School of Education since 2016. Her research focuses on translational studies to explore the reward system in ASD, as well as how anxiety contributes to social challenges in ASD. She also investigates how behavioral interventions affect neural activity, behavior, and school performance in children with ASD. She is also involved in the diagnosis of children with ASD and is a licensed clinical psychologist in California. 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She has run and participated in several funded and non-funded projects on the teaching of Science, Social Sciences, and ICT in education. She also has the experience of participating in five Erasmus+ projects.",institutionString:"University of Crete",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}},editorThree:null},{id:"90",title:"Human Development",coverUrl:"https://cdn.intechopen.com/series_topics/covers/90.jpg",isOpenForSubmission:!0,annualVolume:11974,editor:{id:"191040",title:"Dr.",name:"Tal",middleName:null,surname:"Dotan Ben-Soussan",slug:"tal-dotan-ben-soussan",fullName:"Tal Dotan Ben-Soussan",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBf1QAG/Profile_Picture_2022-03-18T07:56:11.jpg",biography:"Tal Dotan Ben-Soussan, Ph.D., is the director of the Research Institute for Neuroscience, Education and Didactics (RINED) – Paoletti Foundation. Ben-Soussan leads international studies on training and neuroplasticity from neurophysiological and psychobiological perspectives. As a neuroscientist and bio-psychologist, she has published numerous articles on neuroplasticity, movement and meditation. She acts as an editor and reviewer in several renowned journals and coordinates international conferences integrating theoretical, methodological and practical approaches on various topics, such as silence, logics and neuro-education. 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She is a member of the Coordination and Scientific Committees of the doctoral program “Tropical Knowledge and Management” (NOVA), Master in Biotechnology (UEM), and Master in Conservation Biology (GNP); and a national expert for Food and Nutrition Security and Sustainable Agriculture - High-Level Policy Dialogue EU-Africa. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:229,paginationItems:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",biography:"Dr. Aneesa Moolla has extensive experience in the diverse fields of health care having previously worked in dental private practice, at the Red Cross Flying Doctors association, and in healthcare corporate settings. She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",country:{name:"Spain"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\r\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\r\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Orthodontist, Assoc Prof in the Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. Her knowledge of English is at an advanced level.",institutionString:null,institution:null},{id:"332914",title:"Dr.",name:"Muhammad Saad",middleName:null,surname:"Shaikh",slug:"muhammad-saad-shaikh",fullName:"Muhammad Saad Shaikh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jinnah Sindh Medical University",country:{name:"Pakistan"}}},{id:"315775",title:"Dr.",name:"Feng",middleName:null,surname:"Luo",slug:"feng-luo",fullName:"Feng Luo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sichuan University",country:{name:"China"}}},{id:"344229",title:"Dr.",name:"Sankeshan",middleName:null,surname:"Padayachee",slug:"sankeshan-padayachee",fullName:"Sankeshan Padayachee",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"315727",title:"Ms.",name:"Kelebogile A.",middleName:null,surname:"Mothupi",slug:"kelebogile-a.-mothupi",fullName:"Kelebogile A. Mothupi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"423519",title:"Dr.",name:"Sizakele",middleName:null,surname:"Ngwenya",slug:"sizakele-ngwenya",fullName:"Sizakele Ngwenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"337613",title:"Mrs.",name:"Tshakane",middleName:null,surname:"R.M.D. Ralephenya",slug:"tshakane-r.m.d.-ralephenya",fullName:"Tshakane R.M.D. Ralephenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419270",title:"Dr.",name:"Ann",middleName:null,surname:"Chianchitlert",slug:"ann-chianchitlert",fullName:"Ann Chianchitlert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419271",title:"Dr.",name:"Diane",middleName:null,surname:"Selvido",slug:"diane-selvido",fullName:"Diane Selvido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419272",title:"Dr.",name:"Irin",middleName:null,surname:"Sirisoontorn",slug:"irin-sirisoontorn",fullName:"Irin Sirisoontorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}}]}},subseries:{item:{id:"4",type:"subseries",title:"Fungal Infectious Diseases",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11400,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null,series:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188"},editorialBoard:[{id:"302145",title:"Dr.",name:"Felix",middleName:null,surname:"Bongomin",slug:"felix-bongomin",fullName:"Felix Bongomin",profilePictureURL:"https://mts.intechopen.com/storage/users/302145/images/system/302145.jpg",institutionString:null,institution:{name:"Gulu University",institutionURL:null,country:{name:"Uganda"}}},{id:"45803",title:"Ph.D.",name:"Payam",middleName:null,surname:"Behzadi",slug:"payam-behzadi",fullName:"Payam Behzadi",profilePictureURL:"https://mts.intechopen.com/storage/users/45803/images/system/45803.jpg",institutionString:"Islamic Azad University, Tehran",institution:{name:"Islamic Azad University, Tehran",institutionURL:null,country:{name:"Iran"}}}]},onlineFirstChapters:{paginationCount:10,paginationItems:[{id:"82804",title:"Psychiatric Problems in HIV Care",doi:"10.5772/intechopen.106077",signatures:"Seggane Musisi and Noeline Nakasujja",slug:"psychiatric-problems-in-hiv-care",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82817",title:"Perspective Chapter: Microfluidic Technologies for On-Site Detection and Quantification of Infectious Diseases - The Experience with SARS-CoV-2/COVID-19",doi:"10.5772/intechopen.105950",signatures:"Andres Escobar and Chang-qing Xu",slug:"perspective-chapter-microfluidic-technologies-for-on-site-detection-and-quantification-of-infectious",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82667",title:"Perspective Chapter: Analysis of SARS-CoV-2 Indirect Spreading Routes and Possible Countermeasures",doi:"10.5772/intechopen.105914",signatures:"Cesare Saccani, Marco Pellegrini and Alessandro Guzzini",slug:"perspective-chapter-analysis-of-sars-cov-2-indirect-spreading-routes-and-possible-countermeasures",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82559",title:"Perspective Chapter: Bioinformatics Study of the Evolution of SARS-CoV-2 Spike Protein",doi:"10.5772/intechopen.105915",signatures:"Črtomir Podlipnik, Radostina Alexandrova, Sebastian Pleško, Urban Bren and Marko Jukič",slug:"perspective-chapter-bioinformatics-study-of-the-evolution-of-sars-cov-2-spike-protein",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82521",title:"Challenges in Platelet Functions in HIV/AIDS Management",doi:"10.5772/intechopen.105731",signatures:"Gordon Ogweno",slug:"challenges-in-platelet-functions-in-hiv-aids-management",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82552",title:"Perspective Chapter: SARS-CoV-2 Variants - Two Years Post-Onset of the Pandemic",doi:"10.5772/intechopen.105913",signatures:"Adekunle Sanyaolu, Aleksandra Marinkovic, Stephanie Prakash, Chuku Okorie, Abdul Jan, Priyank Desai, Abu Fahad Abbasi, Jasmine Mangat, Zaheeda Hosein, Kareem Hamdy, Nafees Haider, Nasar Khan, Rochelle Annan, Olanrewaju Badaru, Ricardo Izurieta and Stella Smith",slug:"perspective-chapter-sars-cov-2-variants-two-years-post-onset-of-the-pandemic",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82367",title:"Spatial Variation and Factors Associated with Unsuppressed HIV Viral Load among Women in an HIV Hyperendemic Area of KwaZulu-Natal, South Africa",doi:"10.5772/intechopen.105547",signatures:"Adenike O. 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We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. 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