Mechanisms of action of the main types of IUDs. Modified, Schulman et al. [35].
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"8067",leadTitle:null,fullTitle:"Molecular Docking and Molecular Dynamics",title:"Molecular Docking and Molecular Dynamics",subtitle:null,reviewType:"peer-reviewed",abstract:"This book clearly explains the principles of in silico tools of molecular docking and molecular dynamics. It provides examples of algorithms and procedures proposed by different software programs for visualizing and identifying potential interactions in complexes of biochemical interest. The book is structured in six chapters, each of which discusses different molecular simulation methodologies and provides concrete examples of complexes interactions. In each chapter authors give an overview of the treated subject, a description of the methodologies used, and a discussion of the results. The authors describe computational ways to achieve a rational design of bioactive compounds with various therapeutic applications, including antitumoral agents, antitubercular drugs, nonsteroidal anti-inflammatory drugs, and radiopharmaceuticals.",isbn:"978-1-78984-092-6",printIsbn:"978-1-78984-091-9",pdfIsbn:"978-1-78985-262-2",doi:"10.5772/intechopen.77898",price:100,priceEur:109,priceUsd:129,slug:"molecular-docking-and-molecular-dynamics",numberOfPages:100,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"1d45bbc09e3ad00be279eea0df45abcc",bookSignature:"Amalia Stefaniu",publishedDate:"December 18th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/8067.jpg",numberOfDownloads:6568,numberOfWosCitations:8,numberOfCrossrefCitations:8,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:13,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:29,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 12th 2018",dateEndSecondStepPublish:"November 5th 2018",dateEndThirdStepPublish:"January 4th 2019",dateEndFourthStepPublish:"March 25th 2019",dateEndFifthStepPublish:"May 24th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"213696",title:"Dr.",name:"Amalia",middleName:null,surname:"Stefaniu",slug:"amalia-stefaniu",fullName:"Amalia Stefaniu",profilePictureURL:"https://mts.intechopen.com/storage/users/213696/images/system/213696.jpg",biography:"Amalia Stefaniu has a background in chemical engineering, acquiring her Bachelor’s degree at Politehnica University of Bucharest, Faculty of Engineering in Foreign Languages. She followed postgraduate academic studies with Drugs and Cosmetics specialization and she obtained a Masters degree in Biotechnologies and food safety. She completed her PhD in Exact Sciences - Chemistry Domain in 2011 at the University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry. She joined the National Institute for Chemical Pharmaceutical Research and Development, Bucharest in 2001, where she worked first as Chemical Research Engineer in the Pharmaceutical Biotechnologies domain. Her current position is Senior Research Scientist. Her research focuses on properties prediction, mathematical modeling, molecular docking, and therapeutic compounds design.",institutionString:"National Institute for Chemical - Pharmaceutical Research and Development",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"2",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1195",title:"Drug Discovery",slug:"pharmacology-toxicology-and-pharmaceutical-science-pharmacology-drug-discovery"}],chapters:[{id:"65421",title:"Introductory Chapter: Molecular Docking and Molecular Dynamics Techniques to Achieve Rational Drug Design",doi:"10.5772/intechopen.84200",slug:"introductory-chapter-molecular-docking-and-molecular-dynamics-techniques-to-achieve-rational-drug-de",totalDownloads:1313,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Amalia Stefaniu",downloadPdfUrl:"/chapter/pdf-download/65421",previewPdfUrl:"/chapter/pdf-preview/65421",authors:[{id:"213696",title:"Dr.",name:"Amalia",surname:"Stefaniu",slug:"amalia-stefaniu",fullName:"Amalia Stefaniu"}],corrections:null},{id:"65870",title:"Binding of Chlorinated Phenylacrylonitriles to the Aryl Hydrocarbon Receptor: Computational Docking and Molecular Dynamics Simulations",doi:"10.5772/intechopen.84818",slug:"binding-of-chlorinated-phenylacrylonitriles-to-the-aryl-hydrocarbon-receptor-computational-docking-a",totalDownloads:886,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:0,abstract:"The development of ligands capable of binding to the aryl hydrocarbon receptor (AhR) and hijacking its signaling pathway is of potential use for the design of novel agents against breast cancer. To guide the synthesis of new compounds and characterize their binding to the AhR, we employed homology modeling, ligand docking, and molecular dynamics simulations. As there is currently no crystallographic information available for the structure of the AhR’s ligand-binding PAS-B domain, a homology model was developed. The location of the binding site was identified by scanning the model for concave areas and comparing them to known ligand-binding sites in proteins related to the AhR, such as the CLOCK:BMAL1 transcriptional activator complex and the hypoxia-inducible factor-2α (HIF-2α). Docking of several chlorinated phenylacrylonitriles was performed with the modeling suite MOE, identifying π-π stacking, hydrophobic, and van der Waals interactions as the driving forces for binding, an observation consistent with the hydrophobic nature of the site. Molecular dynamics simulations with one of the compounds for 100 ns verified the overall stability of a docking-predicted pose and revealed the presence of interacting water molecules in the vicinity of the ligand. Given the buried location of the ligand in the core of the receptor, this observation was somewhat unexpected, but it explained a slight shift of the ligand pose seen during the simulation.",signatures:"Stefan Paula, Jennifer R. Baker, Xiao Zhu and Adam McCluskey",downloadPdfUrl:"/chapter/pdf-download/65870",previewPdfUrl:"/chapter/pdf-preview/65870",authors:[null],corrections:null},{id:"66926",title:"In Silico Drug Design and Molecular Docking Studies of Some Quinolone Compound",doi:"10.5772/intechopen.85970",slug:"-em-in-silico-em-drug-design-and-molecular-docking-studies-of-some-quinolone-compound",totalDownloads:1473,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:1,abstract:"Quinolones are an important class of heterocyclic compounds that possess interesting biological activities like antimicrobial, antitubercular, and antitumor. The objective of this study is to evaluate in silico the antitumoral and antimycobacterial activity of some quinolone derivatives by using CLC Drug Discovery Workbench Software. Docking studies were carried out for all ligands, and the docking scores were compared with the scores of standard drugs, topotecan and levofloxacin. The docking studies have been carried out to predict the most possible type of interaction, the binding affinities, and the orientations of the docked ligands at the active site of the target protein.",signatures:"Lucia Pintilie and Amalia Stefaniu",downloadPdfUrl:"/chapter/pdf-download/66926",previewPdfUrl:"/chapter/pdf-preview/66926",authors:[{id:"213696",title:"Dr.",name:"Amalia",surname:"Stefaniu",slug:"amalia-stefaniu",fullName:"Amalia Stefaniu"},{id:"94504",title:"Dr.",name:"Lucia",surname:"Pintilie",slug:"lucia-pintilie",fullName:"Lucia Pintilie"}],corrections:null},{id:"66756",title:"Virtual Screening of Sesquiterpenoid Pogostemon herba as Predicted Cyclooxygenase Inhibitor",doi:"10.5772/intechopen.85319",slug:"virtual-screening-of-sesquiterpenoid-pogostemon-herba-as-predicted-cyclooxygenase-inhibitor",totalDownloads:1013,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"To analyze the structural features that dictate the selectivity of the two isoforms of the cyclooxygenase (COX), the three-dimensional structure of COX-1/COX-2 was assessed by means of binding energy calculation by way of virtual molecular dynamic simulations using ligand sesquiterpenoid Pogostemon herba. This study was conducted to investigate the molecular interaction between ligand alpha-bulnesene (CID94275), alpha-guaiene (CID197152), seychellene (CID519743), and alpha-patchouli alcohol isomers (CID442384, CID521903, CID6432585, CID3080622, CID10955174, and CID56928117) to COX-1 and COX-2. Molecular docking tools proposed by Hex 8.0 were employed in this research. Discovery Studio Client 3.5 software tool and virtual molecular dynamic 1.9.1 software were also used to visualize the molecular interactions identified in this research. In order to calculate the binding energy of the molecular dynamic interaction, AMBER12 software was utilized. Results of the analysis on all sesquiterpenoid indicate that those compounds were the inhibitors of COX-1 and COX-2. Overall, the binding energy calculations (using PBSA Model Solvent) of alpha-patchouli alcohol (CID521903) and seychellene (CID519743) have been identified as the candidates of non-selective inhibitor; alpha-bulnesene (CID94275), alpha-guaiene (CID107152), and alpha-patchouli alcohol isomers (CID6432585, CID3080622, CID10955174, CID56928117) have been suggested as the candidates for a selective COX-1 inhibitor; whereas alpha-patchouli alcohol (CID442384) was the candidate for a selective COX-2 inhibitor.",signatures:"Sentot Joko Raharjo",downloadPdfUrl:"/chapter/pdf-download/66756",previewPdfUrl:"/chapter/pdf-preview/66756",authors:[null],corrections:null},{id:"65166",title:"Protein-Protein Docking Using Map Objects",doi:"10.5772/intechopen.83543",slug:"protein-protein-docking-using-map-objects",totalDownloads:832,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Protein-protein docking is a molecular modeling strategy to predict biomolecular complexes and assemblies. Traditional protein-protein docking is performed at atomic resolution, which relies on X-ray and NMR experiments to provide structural information. When dealing with biomolecular assemblies of millions of atoms, atomic description of molecular objects becomes very computational inefficient. This article describes a development work that introduces map objects to molecular modeling studies to efficiently derive complex structures through map-map conformational search. This method has been implemented into CHARMM as the EMAP command and into AMBER in its SANDER program. This development enables molecular modeling and simulation to manipulate map objects, including map input, output, comparison, docking, etc. Through map objects, users can efficiently construct complex structures through protein-protein docking as well as from electron microscopy maps according to low map energies. Using a T-cell receptor (TCR) variable domain and acetylcholine binding protein (AChBP) as example systems, we showed the application to model an energetic optimized complex structure according to a complex map. The map objects serve as a bridge between high-resolution atomic structures and low-resolution image data.",signatures:"Xiongwu Wu and Bernard R. Brooks",downloadPdfUrl:"/chapter/pdf-download/65166",previewPdfUrl:"/chapter/pdf-preview/65166",authors:[{id:"104593",title:"Dr.",name:"Xiongwu",surname:"Wu",slug:"xiongwu-wu",fullName:"Xiongwu Wu"},{id:"111719",title:"Dr.",name:"Bernard",surname:"Brooks",slug:"bernard-brooks",fullName:"Bernard Brooks"}],corrections:null},{id:"66152",title:"Computational Study of Radiopharmaceuticals",doi:"10.5772/intechopen.85140",slug:"computational-study-of-radiopharmaceuticals",totalDownloads:1054,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Radiopharmaceuticals contain radionuclides and pharmaceuticals. Research on radiopharmaceuticals has been increasing in recent years by increasing the importance of early diagnosis in diseases. It is generally accepted that investigation and development of new radiopharmaceuticals are time and resource consuming. Computational methods have provided exciting contributions to pharmaceutical research and development. The need for designing new radiopharmaceutical drugs enhances the importance of computational programs. At this point, the structure, chemical, physical and physicochemical properties of molecules should be predicted/evaluated by using computational methods. While these methods obtain useful estimates, they make it easier for researchers and clinicians to make the right choices. Also, by providing accurate and effective results, they contribute to reduce the cost of research and can be used to simulate complex biochemical situations before research helping us to avoid harmful effects of drugs. In this study, authors emphasis about radiopharmaceuticals and the computational tools related to the development of new radiopharmaceuticals.",signatures:"Emine Selin Demir, Emre Ozgenc, Meliha Ekinci, Evren Atlihan Gundogdu, Derya İlem Özdemir and Makbule Asikoglu",downloadPdfUrl:"/chapter/pdf-download/66152",previewPdfUrl:"/chapter/pdf-preview/66152",authors:[null],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"9236",title:"Cheminformatics and its Applications",subtitle:null,isOpenForSubmission:!1,hash:"3fed97d1719b8a321190c86985494a34",slug:"cheminformatics-and-its-applications",bookSignature:"Amalia Stefaniu, Azhar Rasul and Ghulam Hussain",coverURL:"https://cdn.intechopen.com/books/images_new/9236.jpg",editedByType:"Edited by",editors:[{id:"213696",title:"Dr.",name:"Amalia",surname:"Stefaniu",slug:"amalia-stefaniu",fullName:"Amalia Stefaniu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"671",title:"Drug Discovery and Development",subtitle:"Present and Future",isOpenForSubmission:!1,hash:"74072e600a9fb54b8257355a7954399e",slug:"drug-discovery-and-development-present-and-future",bookSignature:"Izet M. 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Intrauterine devices (IUDs) represent long-lasting reversible birth control method [1] with the greatest satisfaction among users [2]. However, this contraceptive use generated much heated discussion and debates, with exhaustive studies that are presented in the present chapter.
Intrauterine contraception with various devices seems to have a long history, from the ancient Arabs who placed round smooth stones in the camels’ uteri to prevent conception during long journeys. In the late nineteenth century, intracervical devices have been used to prevent pregnancy or to induce abortion [3]. Still, the first medical communication on medical IUD was published in Germany, at the beginning of the twentieth century by Richter [4], who reported the results of intrauterine insertion of a metallic ring with catgut tied around it. In the 1920s, Ernest Graefenberg attached a silver wire to the ring for Roentgen visualization, but silver rings were rapidly abandoned as they led to gingival argyrosis. An alloy of copper, nickel, and zinc was used instead [5]. In 1959, the first paper was published who condemned the IUDs as dangerous because of the ineffectiveness, risk of infection, and carcinogenic potential [5]. The modern IUDs evolved from 1960 with a T-shaped product that configured better to the natural shape of the uterus [6]. By the mid-1960s, IUDs became a widely used method with fewer potential cardiovascular risks when compared to oral contraceptives [7]. In 1970, nearly 10% of women were using the Dalkon Shield IUD as a contraceptive method. Since then, the use of IUDs dropped because of the severe septic cases reported, along with the increased risk of pelvic inflammatory disease (PID) and infertility [8]. IUDs were even withdrawn from the US market between 1986 and 1988.
Since the introduction of the levonorgestrel 52 mg IUD in 2001, this intervention achieved a new, therapeutic, dimension—because of significant benefits in treating heavy menstrual bleeding and dysmenorrhea [7].
Today, IUDs are an important component of family planning, as they are used by one in 10 women in the USA and 9–24% of all contraceptives in European countries [9]. The highest rates of IUD use are recorded in Asia: 40% of women in China, 50% in Korea, and 56% in Uzbekistan [10], while the lowest rates are recorded in Africa. The trend of contraceptive method is declining as the use of injectable products is increasing [11]. From the beginning, the gynecologists were preferred for a safe insertion of the IUD, instead of general practitioners [3].
The two main types of IUDs are the copper non-hormonal device and the hormonal device.
There are a few types of
Other types of copper IUDs include the
The
Besides pure copper devices, there is also a gold IUD called
Silver was also being added on a copper device, to reduce fragmentation, and to prolong the lifespan of the device. The production of the initial
To reduce side effects of IUDs such as bleeding, pain, and expulsion,
Since 1976, medicated or
Other IUDs include the
In Austria and Israel, a
New IUDs, such as flexible VeraCept—that utilize a low-dose copper configuration of 175 mm2 surface area on a shape memory Nitinol frame—need clinical trials for validation of efficacy and tolerability [20] (Figures 1 and 2).
Various types of IUD. Copper devices presented in the upper row, from left to right: T Safe Cu380A®, Nova T380®, Flexi-T300®, Multiload Cu375®, GyneFix®, Ocon® Cooper intrauterine ball. In the middle row—hormonal IUDs: Mirena®, Skyla®, FibroPlant® frameless levonorgestrel-releasing device. In the lower row, other IUD types are presented, as the indomethacin-releasing cooper device AiMu® and the flexible, low copper dose VeraCept®.
General structure with stems, arms, and strings of the IUD. Normal location after proper IUD insertion in the middle of the endometrial cavity with no extension in the myometrium, both arms spread toward the uterine horns and the inferior part of the vertical body stem just above the isthmus.
Both copper and hormonal IUDs involve multiple mechanisms that provide contraceptive protection. The major described effect is represented by the induction of a
Besides the foreign body reaction, another mechanism of the
We underline that IUDs, whether hormonal or non-hormonal, do not provide protection against sexually transmitted diseases. Still, the historical association with pelvic inflammatory disease (PID) and tubal infertility is considered false [31, 32].
The indomethacin-releasing copper IUD contains a nonsteroidal anti-inflammatory agent, indomethacin, that do not interfere with copper ions [33, 34], aimed to reduce the menstrual blood flow and cramping that are frequently related by IUDs users [33] (Table 1).
Mechanisms of action | Type of intrauterine device | |
---|---|---|
Copper IUD | Hormonal levonorgestrel IUD | |
Foreign body reaction with toxic changes to sperm | + | + |
Copper ions spermicidal or cytotoxic | + | |
Thickened cervical mucus affecting sperm motility | + | |
Decreased number of fertilized ova in fallopian tubes | + | + |
Immune-inflammatory reaction with increased leukocytes | + | |
Altered cytotoxic cytokine and integrin profile | + | + |
Endometrial atrophy, decreased thickness, and secretions | + |
Mechanisms of action of the main types of IUDs. Modified, Schulman et al. [35].
Generally, all IUDs are well tolerated with high rates of continuation in all reversible contraception types [36]. All IUD types present potential side effects: uterus perforation and malposition, especially during the inserting technique; embedment and expulsion, as it is a foreign body, and menstrual pattern alterations (Figure 3). All patients should be counseled regarding the possibility of IUD expulsion as this is the most common complication following IUD insertion [37].
IUDs complications. (A): complete uterine perforation; (B): partial uterine perforation; (C): partial embedment into myometrium; (D): malposition; (E): expulsion after insertion.
The
Uterine
A rarely reported complication is the
Copper IUDs can cause
Regarding the
The
The major
Another IUD benefit is the fact that it can be used as an adjunctive treatment modality for intrauterine adhesions. Several studies have shown that IUD can be beneficial in patients with intrauterine adhesions or Asherman’s syndrome, especially when combined with other ancillary treatments [51].
Other noncontraceptive benefits of IUDs include the treatment of menorrhagia, anemia, dysmenorrhea and pelvic pain associated to endometriosis, and endometrial protection during hormone replacement [48]. Since 2009, when Food and Drug Administration (FDA) approved the hormonal IUD as treatment for heavy menstrual bleeding, hormonal IUDs became the most cost-effective alternative to hysterectomy/surgery for the respective patients, with improved hemoglobin concentration [52]. Studies report a decrease of the menstrual blood loss that varies between 74 and 97% at 12 months of use [53, 54]. First, an initial irregular bleeding pattern is noted by most users, but over time the menstrual blood loss is improved. In contrast with copper IUD, the hormonal IUD can also decrease dysmenorrhea [55].
In 30% of patient with deep endometriosis or adenomyosis, an improved control of chronic pelvic pain and dyspareunia is noted after at least 6 months of hormonal IUD use [56, 57].
As the main effect of hormonal IUDs is to decrease the local endometrial response to estrogen, several studies have suggested that this may lead to primary protection from endometrial cancer [58]. Hormonal IUDs can also be used as a component of combined hormone therapy in menopausal women [52].
The use of IUD contraception is considered a health benefit in special groups such as women with comorbidities, in postpartum, postabortion and lactating women, patients with prior thromboembolic events, bleeding diathesis, or under anticoagulation. Also, IUD contraception can be a preferable option in women with uterine fibroids after uterine artery embolization, endometrial ablation, or magnetic resonance-guided focused ultrasound.
However, the IUD does not protect from sexually transmitted diseases; therefore, caution must be considered when selecting IUD users.
Since the introduction of IUDs, scientists manifested a concern that this contraception method may cause or facilitate gynecologic infection. In fact, the relationship between IUD and PID has a long and controversial history dating since 1940 [59]. Moreover, in the 1970s, the reputation of IUD was tarnished in many countries, as the use of a Dalkon Shield IUD was linked to several cases of potentially fatal pelvic sepsis [60]. Today, although there is common reserve regarding the PID incidence in the IUD users’ population, valuable research has shown that the risk of PID is no greater with IUD use than the general population [61]. WHO admits a risk of six times greater of PID in the first 20 days after the insertion of IUD [61]. One randomized trial found that the hormonal IUD might provide some protection against PID when compared to the group of copper IUD users and the group of IUD non-users [62]. Due to this risk, prophylactic antibiotics were proposed before IUD insertion, especially doxycycline and/or azithromycin. Multiple large, randomized control studies have demonstrated that the prophylactic antibiotic has no significant beneficial role in reducing the risk of PID before IUD insertion [63].
Tubal infertility was thought to be a consequence of IUD use. Specific research has been conducted and found that the past use of copper IUD did not increase the risk of tubal infertility [59]. Chlamydia infection is the primary cause of PID and tubal infertility in women who use or do not use IUD [31]. A cervix already infected with Chlamydia was considered to be a risk factor for placing an IUD, but proved to have no association with PID on later development [64].
In the past, IUD was perceived as a high risk factor for ectopic pregnancies (EPs). Actually, a pregnancy with an IUD in situ has an increased risk of being an EP, but the absolute risk of any pregnancy is extremely low in the group of IUD users, much lower than in the group of women with no contraception method [65, 66]. Another important aspect to highlight is that a history of previous EP does not represent a contraindication for IUD insertion [67].
Adolescents and nulliparous women represent a special group that was considered, in the past, not eligible for IUD contraception. Approximately half of adolescents have never heard of IUD contraception [68]. What is more, approximately one-third to one-half of health providers do not offer IUD contraception method to nulliparous women due to several myths and misconceptions [69]. Nowadays, there is sufficient evidence to support the use of IUDs in the nulliparous women as a suitable contraception method, regardless of all false myths and misconceptions including high risk of PID, tubal infertility, EP, gynecological neoplasia, difficulties of the insertion technique, and IUD expulsion [70].
There is a lack of awareness and understanding of IUD contraception by women worldwide, possibly due to lack of medical education and proper information. A frequent misconception of IUD use is that it increases the risk of genital cancer. Mandatory screening for cervical cancer is a requirement of many guidelines before IUD insertion. In fact, several epidemiological studies suggested that IUDs might protect against cervical carcinogenesis [71]. The role of hormonal IUD as a protective factor against endometrial hyperplasia is well known [58]. Accurate information regarding the use of hormonal IUD must underline the risk of ovarian cysts, but not ovarian cancer.
Female sexual dysfunction was thought to be determined by IUD but in fact has a multifactorial etiology and studies found no difference between IUD users or non-users [72].
IUD represents the choice method of contraception for many women as its effects are reversible after removal.
The insertion technique is easy and well tolerated by selected female patients after taking into consideration the contraindications, as well as the health benefits for women with anemia, menorrhagia, or dysmenorrhea [73]. First, it is advisable to have a documentation of a negative pregnancy test as a precaution. Also, exclusion of a possible Chlamydia or gonorrhea is advisable before an IUD is inserted [74]. The insertion can be performed at any time during the menstrual cycle [42]. In the past, the technique was preferred to be done during menses to exclude pregnancy, but this is associated with a higher risk of expulsion. Several studies found that the pain during the insertion is lower during the sixth and the tenth days of the menstrual cycle [26]. Regarding the insertion of a hormonal IUD, the appropriate timing is considered to be within the first 5 days of menstrual bleeding or immediately after childbirth, abortion, or switching from an alternative contraceptive method [42, 75]. Backup contraception is recommended for a period of 7 days after the hormonal IUD insertion and is not needed after the copper IUD insertion [48]. In cases of emergency contraception, the insertion of the copper IUD can be done within the 5 days of the unprotected intercourse to prevent pregnancy [25]. The use of a hormonal IUD has not been yet studied and so it is not recommended for emergency contraception. The removal of both the copper IUD and the hormonal IUD can be performed anytime preferably during the menstrual cycle. As mentioned before, antibiotic prophylaxis is not needed before IUD insertion or removal, even in patients at risk for endocarditis [76]. The insertion procedure is usually done by a trained provider in the office, and only in special circumstances, such as mentally limited patients and nulliparous young women, it can be done under sedation. The physician must discuss all risks and benefits of IUD with the patient and must obtain an informed consent. The use of misoprostol before IUD insertion to allow an easier procedure was proposed in 2007 [77]. However, more recent researches found no benefit but increased side effects with misoprostol, and no recommendation has been yet made [78, 79]. On the other hand, the use of a nonsteroidal anti-inflammatory drug, respectively, 600–800 mg of ibuprofen 1 h before the procedure can alleviate discomfort [80]. Also, the physician must educate the patient in locating the IUD threads after each menstruation and consulting earlier if incapacity to locate [80]. IUD insertion is similar for copper IUD and for hormonal IUD. The preparation before IUD insertion must include the determination of uterus position. This can be done by a bimanual examination or by an ultrasound examination. All proper equipment must be sterile and assembled before the procedure. The cervix and vagina must be cleansed with antiseptic solution. A speculum is used to visualize the cervix and a tenculum to stabilize the cervix. Local anesthesia is preferred with lidocaine gel in the cervical canal, or a paracervical block. The uterine depth must be verified using a hysterometer and the IUD is inserted as shown in the accompanying written material of any IUD. After proper insertion, the threads should be cut to a length of 3 cm. A post-procedure ultrasound should be performed to verify the IUD position [81]. The removal procedure should be considered anytime on patient request. If any contraindication appears or adverse effects persist, IUD can be easily removed by grasping the threads at the external os. Special conditions include impossibility to remove the IUD with a simple traction; deeply embedment IUD should be suspected and in such cases, hysteroscopy is mandatory. Cervical screening is performed the same as in IUD non-users. Colposcopy is performed the same, but excisional procedure for cervical dysplasia must be performed after IUD removal [81].
US evaluation of the pelvis, especially transvaginally, has become an important part of the gynecological care and is essential for the assessment of IUD position after insertion [81]. Moreover, the lack of a pelvic US examination before IUD insertion may predispose to malposition or serious complications such as perforation [82]. US assessment is cheap, easy to learn, perform and interpret, efficient, and without side effects [81]. A correct positioned IUD is visualized in the middle of the endometrial cavity with no extension in the myometrium, with both arms spread toward the uterine horns and the inferior part of the vertical body of the IUD just above the isthmic portion of the uterus [83] (Figure 4). The two-dimensional technique has some limits in the evaluation of the IUD position, as the most important plane for this purpose, the coronal plane, usually cannot be imagined. Three-dimensional (3D) assessment is also helpful to identify hormonal IUD, because of the lack of echogenicity (Figure 4B), unlike copper IUD that are easily identified due to its high echogenity.
Ultrasound image of hormonal IUD. (A) 2D image; (B) 3D rendering, with reconstruction of the coronal plane.
About 10% of IUDs are malpositioned and so the efficacy in contraception is significantly decreased. More than half of the patients with a malpositioned IUD are asymptomatic. Still, there are no general guidelines for a routine transvaginally US verification after IUD insertion [84]. The 3D US technique has the advantage to allow subsequent reconstruction of the coronal plane [83]. This approach provides a correct diagnosis regarding the malposition, expulsion, displacement, embedment, or perforation (Figure 5). It can also detect more specifically uncommon complications such as fragmentation and calcification [81]. So, 3D has become crucial as it is more sensitive in assessing symptomatic IUD users, but also for routine evaluation. However, familiarity with the transvaginal 2D/3D US techniques is essential.
Ultrasound image of a malpositioned copper IUD. (A) 2D image; (B) 3D rendering of the coronal plane showing copper IUD displacement; (C) 3D rendering showing copper IUD partial embedment into myometrium.
Patient satisfaction and acceptability are extremely important regardless of their contraceptive method. After a proper counseling regarding the risks and the benefits, women choose the appropriate most effective contraception option to prevent an undesired pregnancy. The
Another reason for discontinuation is represented by irregular
Most cases of discontinuation can be prevented by an accurate medical informed discussion between the user and the health provider prior to IUD insertion. Both types of IUD should be taken into consideration and the best decision must consider the benefits, but also all adverse effects. The most important disadvantage of IUD use is the fact that it does not offer protection from sexually transmitted diseases and condom should be used for this purpose. In rare cases, the male partner can feel the IUD retrieval strings or stem during intercourse and this may bother him. Strings can be cut shorter or in some cases the IUD can be removed and a new one inserted. Lack of medical education seems to be the main cause for the reduced uptake and continuation rates for intrauterine contraception among female patients [90].
Other contraception methods should be considered if
During the insertion procedure,
If the IUD is partially
A series of medical conditions, due to high maternal mortality rates approaching 50%, represent an imperative indication for the most reliable methods of contraception in women. Essure was introduced in 2002 as a new sterilization method for women who do not desire to preserve fertility or for those who have significant medical contraindications. Essure is composed of two intra-tubal stents that must be inserted into the proximal section of the fallopian tube. This procedure is done hysteroscopically using only oral analgesia or sedation [91]. The contraceptive effect is installed in 3 months after insertion due to mechanical obstruction and inflammation causing fibrosis [92]. Thus, an additional form of contraception must be used in the meantime other than IUD. The main advantages of Essure are represented by the fact that Essure is non-incisional, permanent birth control device [93]. The insertion procedure is ideally performed in the proliferative phase when the tubal ostia can be easily visualized and cannulated. Tubal stenosis and tubal spasm can determine the failure of placement, but also poor visualization [94]. The procedure success rate varies from 85 to 98% [95]. When inserted, there is a risk of vaso-vagal attacks of 1.85% [96]. The Essure contraindications are the uncertainty regarding ending fertility, suspected pregnancy, active or recent PID, uterine anomalies, less than a 6-week interval after delivery or miscarriage, patient unwilling to use other contraceptive methods for the first 3 months, prior tubal ligation, and current immunosuppressive therapy [97]. After 3 months post-insertion, an imaging method to verify the position of the Essure is recommended. Several studies have been done in order to establish the best imaging method between hysterosalpingogram (HSG), X-ray, or hysterosalpingo-contrast sonography. Still, all studies underline the importance of trained staff in assessing the appropriate Essure placement [93] (Figure 6). As complications, mild pain has been reported in most cases—80% of patients, while severe pain may be encountered in 17% [98]. Also, minor symptoms like cramping, nausea, and light bleeding or spotting can also occur in the first week [3]. Severe complications like tubal perforation and expulsion are rare. Essure is compatible with 1.5 T of magnetic resonance imaging (MRI), but special caution is indicated in 3 T MRI and with some techniques of endometrial ablation. In terms of efficacity, Essure has a 99.74% successful rate in permanent contraception after 5 years [97]. The minimal risk of pregnancy with Essure can be overcome by educating patients to respect the recommended instructions and comply to periodic follow-ups, including HSG protocol [98].
The Essure system and placement of the device.
Gravitational waves are ripples in the curvature of spacetime that propagate like waves, traveling outward from the source; they travel at the speed of light (299,792,458 m/s) and squeeze and stretch anything in their path as they pass. Do not confuse it with gravity waves that are waves generated when the force of gravity in a fluid medium or, when it is the case, at the interface between two different media, tries to restore equilibrium, as an example of these waves there are the wind waves on the interface between the atmosphere and the ocean.
Predicted in 1916 [1, 2] by Albert Einstein based on his theory of general relativity, [3] and detected in 2015, gravitational waves transport energy in the form of gravitational radiation, oscillation of spacetime itself. This theory predicts that the presence of mass causes spacetime to warp. When massive objects move around themselves, this curvature is altered, sending ripples of gravitation out of the universe carrying unbelievable amounts of energy. As these sources are very distant by the time, these disturbances catch up with us; they are almost imperceptible because they are weaker and gravitational waves interact very weakly with matter. Because of that, it was only a century after Einstein’s prediction that scientists developed a sensitive enough detector—a Laser Interferometer Gravitational-Wave Detector, some kilometers long interferometer and were able to confirm the existence of gravitational waves [4].
The existence of gravitational waves is also a consequence of the Lorentz covariance of general relativity since it brings the concept of a finite speed of propagation of gravity. Gravitational waves did not exist in the Newtonian theory of gravitation, which postulates that physical interactions propagate at infinite speed.
There was already indirect evidence of gravitational waves before its first direct detection. Measurements of the Hulse-Taylor binary system suggested that gravitational waves were more than a hypothetical concept. This system is one of the potential sources of detectable gravitational waves. These potential sources include binary compact star systems composed of white dwarfs, neutron stars, and black holes.
0ne way of thinking about gravitational radiation is as the messenger that carries information about changes in gravitational fields that attract one thing to another [5].
Several gravitational wave observatories (detectors) are under construction or in operation around the world [6]. In 2017, the Nobel Prize in Physics was awarded to Rainer Weiss, Kip Thorne, and Barry Barish for their role in detecting gravitational waves [7]. In these gravitational wave detectors and previous ones, the use of interferometry was essential for the operation of such a detector.
The possibility of gravitational waves was discussed in 1893 by Oliver Heaviside using the analogy between the inverse square law of distance in gravitation and electricity [7]. In 1905, Henri Poincaré proposed for the first time the existence of gravitational waves, which emanated from accelerated bodies and propagated at the same speed of light, this is dictated by the transformations of Lorentz [8] and implies an analogy that, accelerating electric charges produce electromagnetic waves, accelerating masses must emanate gravitational waves. When publishing his theory of gravitation (the general theory of relativity) in 1915, Einstein did not agree with Poincaré’s proposal, as in his theory there are not gravitational dipoles, essential for the emission in the electromagnetism theory. However, based on a weak field approximation, he concluded that there should be three kinds of gravitational waves (named by Hermann Weyl as longitudinally-longitudinally, transversely-longitudinally, and transversely-transverse).
These approximations made by Einstein were criticized by several researchers and even Einstein had doubts. In 1922, Arthur Eddington wrote a paper entitled: “The propagation of gravitational waves” [8], in which he showed that two of the three types of waves proposed by Einstein were only mathematical artifacts produced by the system of coordinates and they were not really waves. This also cast doubt on the physicality of the third type (transversely transverse); however, Eddington proved that these would travel at the speed of light in all coordinate systems, so he did not rule out their existence.
In 1956, Felix Pirani corrected the confusion caused by the use of several coordinate systems by reformulating gravitational waves as the manifestation of the Riemann tensor observables. The Pirani work was ignored at that time mainly because the scientific community was concerned with another issue of whether gravitational waves could transport energy. This question was solved by Richard Feynman using a thought experiment presented at the first conference for General Relativity in 1957 known as the Chapel Hill Conference. His argument, known as the sticky bead argument, presents that: if a gravitational wave passes orthogonally to the beaded rod (a rod if some bead), the effect of it is to deform the bead and the rod, but as the rod is longer, the bead moves beads over the rod; this movement causes friction and then heat, which meant the passing gravitational wave would have energy. Afterward, Hermann Bondi (who was skeptical of the existence of gravitational waves) published a more complete version of this argument.
After this conference, the scientific community took the existence of gravitational waves more seriously. Joseph Weber began to design and build a gravitational wave detector. It was the start of many gravitational wave detectors that are called Weber bars. Weber claimed to have detected gravitational waves in 1969 and 1970, the signals coming from the Galactic Center [9]. However, the high detection frequency quickly cast doubt on the validity of his observations, as the Milky Way’s implied rate of energy loss would drain our galaxy’s energy on a much shorter timescale than the galaxy’s inferred age. It got worse when in the middle of the 1970 decade, the build of other Weber bar experiments by other groups around the world failed to detect such signs. By the end of the 1970 decade, the consensus was that Weber’s detections were some kinds of noise.
The first indirect evidence of gravitational waves was discovered in 1974 by Russell Alan Hulse and Joseph Hooton Taylor Jr., using their discovery of the first binary pulsar. Results were published in 1979, showing the measure of the orbital period decay of the, so-called, Hulse-Taylor pulsar, which precisely describes the angular momentum and energy loss due to gravitational radiation emission predicted by general relativity. A discovery that gave them the 1993 Physics Nobel Prize.
This indirect detection of gravitational waves motivated further searches, despite Weber’s discredited result. Some groups continued to improve on Weber’s original concept. Using very low temperatures (cryogenic) for the bars, in high-vacuum systems and under vibrational isolation. There were many of these projects around the World. One of these groups built a Niobium bar resonant-mass gravitational wave detector [10]. In this detector, the vibrations caused by the passage of gravitational waves in the niobium bar are measured by a microwave parametric transducer. In this system, microwaves are pumped into a microwave cavity and the vibrations of the microwave cavity are connected to the niobium bar causing microwave signals in the microwaves to leave the cavity. This signal now must be amplified, but it mixes with the original microwave signal, which is too strong for the low-noise microwave amplifier; then the microwave carrier signal is removed by the use of an interferometer that cancels only the microwave carrier. A similar system can be seen in Figure 1. This is another use for interferometers in gravitational wave detectors; unfortunately, this kind of detector never made a detection, maybe because of a poor choice in the frequency range [11].
Schematics of a similar electronics of Niobè gravitational wave detector showing a microwave interferometer (between the cryogenic circulator and the cryogenic low-noise amplifier) used to cancel the microwave carrier signal that will degrade the performance of the cryogenic low-noise amplifier.
Other experimental groups pursued gravitational wave detection using laser interferometers. This idea of using appears to have been around for a long time by several independent groups, for example in 1962 ME Gertsenshtein and VI Pustovoit [12] and in 1966 by the group of Vladimir B. Braginskiĭ. The first prototype appeared in the 1970 decade built by Robert L. Forward and Rainer Weiss. In the following decades, increasingly sensitive detectors were constructed, culminating in LIGO and Virgo detectors.
After years and years of null results, the first detection of gravitational waves was made by LIGO on September 14, 2015, as the signal, named GW150914, probably came from the merger of two black holes [13, 14]. A year earlier, LIGO could have been brought down when scientists from the BICEP2 (Background Imaging of Cosmic Extragalactic Polarization 2) experiment claimed to have detected a weak signal in the CMB (Cosmic Microwave Background) that appeared like evidence of gravitational waves originating in the beginning universe. This evidence, according to researchers, could have been a smoking gun proof of the theory of cosmic inflation, which postulates that very shortly after the Big Bang (10−32 seconds after), the expanding universe experienced a period of very rapid expansion (a factor of 1026 times). This fast expansion would have created ripples over the CMB, the fossil cosmic radiation that fills the universe being the first detectable electromagnetic radiation in Universe history. However, the BICEP2 signal detected could be explained also by Milky Way dust, making the scientists withdraw the claim that gravitational waves had been detected.
The interferometry system essentially works by measuring the variations that occur in light beams, which are arranged along two different arms. This analysis occurs when we observe the variations and interferences in the return of the light beams, which overlap, since according to the Theory of Relativity light always travels the same distance using the same time, this is our ideal ruler, eliminating the error of a form of measurement that also suffers from the geometric variations caused by ripples. All this technology must be sensitive enough to be able to detect variations of less than a thousandth of a proton.
A powerful laser beam passes through the beam splitter allowing the two generated beams to have the same phase and to be separated perpendicularly by the arms of 4 km each; at the end, they are reflected by the mirrors [13]. Everything was designed so that normally the phases of the waves of the originally emitted light beam and the reflected one generate a destructive effect, so nothing is detected by the photodetector. For the occasion of a gravitational wave passing by the Earth, causing spacetime expand and contract infinitesimally in one direction, thus generating interference arising from the physical property of the wave behavior of light when the phases produce a more constructive effect, thus a signal is detected. Figure 2 shows the schematics of such a detector.
Schematics of a laser-interferometric GW detector.
This is not so straightforward, as the gravitational wave passes through the detector, the gravitational wave also changes the spacetime between the two mirrors, if this space was made of some material, the length of this material will also change by the gravitational wave, but the passage of gravitational wave does not change the speed of light, then the laser will travel in a shorter time in one arm and a larger time in the other arm then changing the interference pattern in the photodetector.
The fact that there are two observatories is a way of circumventing the possibility of confusing the detection of small earthquakes or some other local source of noise since when detecting a signal, this signal will be compared with that detected by the other observatory. It is only confirmed that this jolt was generated by gravitational waves if the generated signal has the same characteristics, for example, exactly the same profile in frequencies, since the observatories are exactly the same. Importantly, this all takes place in a vacuum, thus ensuring that the light will not have an unstable medium that could alter it in some way. Among the improvements to the observato-ries, the laser was updated to generate a higher frequency, there was an implementation of fused silica in the mirrors to reduce random mirror movements, and also their suspension was improved to reduce thermal noise and seismic isolation, making the observatories more sensitive for detection [14].
In 1974, the most plausible indirect detection of gravitational waves was made by Joseph Taylor, Jr. and Russell Alan Hulse, when observing pulsars surrounding a neutron star (neutron stars are less dense cousins of black holes). That is the Hulse-Taylor binary, a pair of stars, which is a pulsar [15]. The characteristics of its orbit can be deduced from the Doppler shift of radio signals emitted by the pulsar. Each of the stars is about 1.4 M (M being the mass of the Sun) and the radius of their orbits is around 0.013 of the distance between Earth and Sun, smaller than the diameter of the Sun. The combination of smaller separation and bigger masses means that the energy emitted by the Hulse and Taylor binary will be much larger than the energy emitted by the Earth and Sun system by a factor of approximately 1022 times.
Information about the orbit can be used to estimate the amount of energy and angular momentum that would be emitted in the form of gravitational radiation. As the energy is emitted, the pulsars must get closer to each other. Measurements in the Hulse-Taylor system were performed over 30 years ago. The change in the orbital period corresponds to the prediction of gravitational radiation, assumed by general relativity to be within 1 part in 500. Russell Hulse and Joe Taylor, in 1993, were awarded the Physics Nobel Prize for this remarkable work, which was the first indirect evidence of gravitational radiation. This binary system, from the present until the time of the merger, is estimated to have a lifespan of a few hundred million years [16].
After that scientists were motivated to prove its existence. In the mid-1990s they were simulating the Black Hole merger, until the arrival of the Laser Interferometer Gravitational-Wave Observatory (LIGO) and the Italian Gravitational Wave Interferometer Detector (Virgo) at the end of the 20th century made slow progress needing much improvement. The challenge was not the physics itself or the equipment only, but the math behind it. Einstein’s equations are called constraint equations, in which the solutions must always satisfy specific conditions, which is difficult since there are 10 equations with thousands of terms [17]. These simulations were necessary as the detectors needed a set of templates for the detected signal in order to establish the source of the signal, but using numerical relativity the set of these templates is still being built. Just to remember that Bayesian statistics is used in the detection.
In late 2015, researchers from the LIGO (Laser Interferometer Gravitational-Wave Observatory) project observed “distortions in spacetime” caused by a pair of black holes, about 30 solar masses each, in the process of merging [14, 17]. The signal was detected in the two LIGO sites on September 14, 2015 at 6:50:45 a.m. PDT, the event was named GW150914. The signal oscillated from 35 Hz to 250 Hz, with a time difference of 7 × 10−3 s between the detection of each observatory, and a maximum amplitude of 1.0 × 10−21. Thus, coinciding with the shape predicted by Einstein almost exactly 100 years ago for an encounter of massive bodies, in the case of black holes that surround each other until they meet and merge, thus resulting in a significant warping in spacetime. To the relief of many, the merger took place at a distance of ~1.3 billion light-years from Earth. The masses of the initial black holes were 29 M and 36 M, (solar mass, M, approximately 1.99 × 1030 kg); the mass of the resulting black hole was 62M, and approximately 3.0 Mc2 of energy was converted into gravitational waves to the rest of the Cosmos [14]. The signal of this measurement can be seen in Ref. [14]: the detected signal measured in the two observatories (located in Hanford, WA e Livingston, LA) are shown. First row shows the signal detected in the interferometers; it is shown a difference in time signal over the signal at the Louisiana observatory due to difference in the signal arrival time. Second row shows the expected signal of signal for the optimal source template previously calculated. Third row shows the residuals from rows 1 and 2. Row 4 shows the signal in the frequency domain against time.
In June 2016, the second burst of gravitational waves from merging black holes was announced, suggesting that such detections will soon become routine and part of a new kind of astronomy [18].
On June 1, 2017, for the third time, scientists announced that they had detected the infinitesimal reverberations of spacetime [19].
The interferometric gravitational wave detectors are very complex machines, besides being very big vacuum systems, need to have very powerful lasers, and so on. The interferometer must be set in a dark fringe condition, but the mirrors are con-nected to the ground by the suspension, so they vibrate what could change the dark fringe condition. Then a very good suspension that attenuates the vibrations is used, Figure 3 shows an example of such suspension (this example is about the LIGO detector). The Italian detector Virgo has a more sophisticated suspension which makes this detector more sensitive at lower frequencies.
Schematics side view of the mirror suspension system of the LIGO detector showing the electrostatic actuator which is used to keep the detector locked in.
The Virgo suspension is more complex, it is composed of an inverted pendulum and 6 masses suspended by its center, plus a collection of 18 LVDTs (Linear Variable Displacement Transducers), 5 accelerometers, 23 coils, three piezoelectric devices and 21 motor drivers. All these devices together are called the super attenuator. With a super attenuator for every suspended mirror.
These details show that it is very difficult to keep the interferometer locked in, it also depends on active systems.
But how sensitive the interferometer must be to make such measurements. The first measurement of gravitational waves was of displacement 10−18, as the arms are 4 km long, and the variation in length was 4 x 10−15. As the power inside the arms is 100 kW with an input power of 20 W, has a recycling factor of 5000 which makes the real sensitivity of the interferometer close to 10−12 m.
The Gravitational wave interferometric detector successfully detected gravitational waves with unprecedented sensibilities, for the position of the mirror the measurement precision was done in an order of 10−18 meters over square root of Hz. For such achievement, the mirror position should be stable for a factor of 10−13 m r.m.s.
The author acknowledges Conselho de Pesquisa e Desenvolvimento Cientifico (CNPq, Brazil) for Grant #312454/2021-0 and Fundacao de Amparo a Pesquisa do Estado de Sao paulo (FAPESP) Grant #2013/26258-4.
The authors declare no conflict of interest.
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\\n\\nCo-founded by Alex Lazinica and Vedran Kordic: “We are passionate about the advancement of science. As Ph.D. researchers in Vienna, we found it difficult to access the scholarly research we needed. We created IntechOpen with the specific aim of putting the academic needs of the global research community before the business interests of publishers. Our Team is now a global one and includes highly-renowned scientists and publishers, as well as experts in disseminating your research.”
\\n\\nBut, one thing we have in common is -- we are all scientists at heart!
\\n\\nSara Uhac, COO
\\n\\nSara Uhac was appointed Managing Director of IntechOpen at the beginning of 2014. She directs and controls the company’s operations. Sara joined IntechOpen in 2010 as Head of Journal Publishing, a new strategically underdeveloped department at that time. After obtaining a Master's degree in Media Management, she completed her Ph.D. at the University of Lugano, Switzerland. She holds a BA in Financial Market Management from the Bocconi University in Milan, Italy, where she started her career in the American publishing house Condé Nast and further collaborated with the UK-based publishing company Time Out. Sara was awarded a professional degree in Publishing from Yale University (2012). She is a member of the professional branch association of "Publishers, Designers and Graphic Artists" at the Croatian Chamber of Commerce.
\\n\\nAdrian Assad De Marco
\\n\\nAdrian Assad De Marco joined the company as a Director in 2017. With his extensive experience in management, acquired while working for regional and global leaders, he took over direction and control of all the company's publishing processes. Adrian holds a degree in Economy and Management from the University of Zagreb, School of Economics, Croatia. A former sportsman, he continually strives to develop his skills through professional courses and specializations such as NLP (Neuro-linguistic programming).
\\n\\nDr Alex Lazinica
\\n\\nAlex Lazinica is co-founder and Board member of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his Ph.D. in Robotics at the Vienna University of Technology. There, he worked as a robotics researcher with the university's Intelligent Manufacturing Systems Group, as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and, most importantly, co-founded and built the International Journal of Advanced Robotic Systems, the world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career since it proved to be the pathway to the foundation of IntechOpen with its focus on addressing academic researchers’ needs. Alex personifies many of IntechOpen´s key values, including the commitment to developing mutual trust, openness, and a spirit of entrepreneurialism. Today, his focus is on defining the growth and development strategy for the company.
\\n"}]'},components:[{type:"htmlEditorComponent",content:"Our business values are based on those any scientist applies to their research. We have created a culture of respect and collaboration within a relaxed, friendly and progressive atmosphere, while maintaining academic rigour.
\n\nCo-founded by Alex Lazinica and Vedran Kordic: “We are passionate about the advancement of science. As Ph.D. researchers in Vienna, we found it difficult to access the scholarly research we needed. We created IntechOpen with the specific aim of putting the academic needs of the global research community before the business interests of publishers. Our Team is now a global one and includes highly-renowned scientists and publishers, as well as experts in disseminating your research.”
\n\nBut, one thing we have in common is -- we are all scientists at heart!
\n\nSara Uhac, COO
\n\nSara Uhac was appointed Managing Director of IntechOpen at the beginning of 2014. She directs and controls the company’s operations. Sara joined IntechOpen in 2010 as Head of Journal Publishing, a new strategically underdeveloped department at that time. After obtaining a Master's degree in Media Management, she completed her Ph.D. at the University of Lugano, Switzerland. She holds a BA in Financial Market Management from the Bocconi University in Milan, Italy, where she started her career in the American publishing house Condé Nast and further collaborated with the UK-based publishing company Time Out. Sara was awarded a professional degree in Publishing from Yale University (2012). She is a member of the professional branch association of "Publishers, Designers and Graphic Artists" at the Croatian Chamber of Commerce.
\n\nAdrian Assad De Marco
\n\nAdrian Assad De Marco joined the company as a Director in 2017. With his extensive experience in management, acquired while working for regional and global leaders, he took over direction and control of all the company's publishing processes. Adrian holds a degree in Economy and Management from the University of Zagreb, School of Economics, Croatia. A former sportsman, he continually strives to develop his skills through professional courses and specializations such as NLP (Neuro-linguistic programming).
\n\nDr Alex Lazinica
\n\nAlex Lazinica is co-founder and Board member of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his Ph.D. in Robotics at the Vienna University of Technology. There, he worked as a robotics researcher with the university's Intelligent Manufacturing Systems Group, as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and, most importantly, co-founded and built the International Journal of Advanced Robotic Systems, the world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career since it proved to be the pathway to the foundation of IntechOpen with its focus on addressing academic researchers’ needs. Alex personifies many of IntechOpen´s key values, including the commitment to developing mutual trust, openness, and a spirit of entrepreneurialism. Today, his focus is on defining the growth and development strategy for the company.
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Xavier Malcata"}]},{id:"30642",doi:"10.5772/34423",title:"Meiofauna as a Tool for Marine Ecosystem Biomonitoring",slug:"meiofauna-as-a-tool-for-marine-ecosystem-monitoring",totalDownloads:3908,totalCrossrefCites:22,totalDimensionsCites:83,abstract:null,book:{id:"1689",slug:"marine-ecosystems",title:"Marine Ecosystems",fullTitle:"Marine Ecosystems"},signatures:"Maria Balsamo, Federica Semprucci, Fabrizio Frontalini and Rodolfo Coccioni",authors:[{id:"100075",title:"Prof.",name:"Maria",middleName:null,surname:"Balsamo",slug:"maria-balsamo",fullName:"Maria Balsamo"},{id:"104309",title:"Dr.",name:"Federica",middleName:null,surname:"Semprucci",slug:"federica-semprucci",fullName:"Federica Semprucci"},{id:"104311",title:"Dr.",name:"Fabrizio",middleName:null,surname:"Frontalini",slug:"fabrizio-frontalini",fullName:"Fabrizio Frontalini"},{id:"104313",title:"Prof.",name:"Rodolfo",middleName:null,surname:"Coccioni",slug:"rodolfo-coccioni",fullName:"Rodolfo Coccioni"}]},{id:"35136",doi:"10.5772/29571",title:"Transmission Biology of the Myxozoa",slug:"transmission-biology-of-the-myxozoa",totalDownloads:2719,totalCrossrefCites:35,totalDimensionsCites:64,abstract:null,book:{id:"2052",slug:"health-and-environment-in-aquaculture",title:"Health and Environment in Aquaculture",fullTitle:"Health and Environment in Aquaculture"},signatures:"Hiroshi Yokoyama, Daniel Grabner and Sho Shirakashi",authors:[{id:"78409",title:"Dr.",name:"Hiroshi",middleName:null,surname:"Yokoyama",slug:"hiroshi-yokoyama",fullName:"Hiroshi Yokoyama"},{id:"83562",title:"Dr.",name:"Daniel",middleName:"Stefan",surname:"Grabner",slug:"daniel-grabner",fullName:"Daniel Grabner"},{id:"122643",title:"Dr.",name:"Sho",middleName:null,surname:"Shirakashi",slug:"sho-shirakashi",fullName:"Sho Shirakashi"}]},{id:"24078",doi:"10.5772/26795",title:"Photobacterium damselae subsp. damselae, an Emerging Pathogen Affecting New Cultured Marine Fish Species in Southern Spain",slug:"photobacterium-damselae-subsp-damselae-an-emerging-pathogen-affecting-new-cultured-marine-fish-speci",totalDownloads:3789,totalCrossrefCites:19,totalDimensionsCites:45,abstract:null,book:{id:"612",slug:"recent-advances-in-fish-farms",title:"Recent Advances in Fish Farms",fullTitle:"Recent Advances in Fish Farms"},signatures:"A. Labella, C. Berbel, M. Manchado, D. Castro and J.J. Borrego",authors:[{id:"67855",title:"Prof.",name:"Juan J.",middleName:null,surname:"Borrego",slug:"juan-j.-borrego",fullName:"Juan J. Borrego"},{id:"71146",title:"Dr.",name:"Alejandro",middleName:null,surname:"Labella",slug:"alejandro-labella",fullName:"Alejandro Labella"},{id:"71148",title:"Dr.",name:"Concepcion",middleName:null,surname:"Berbel",slug:"concepcion-berbel",fullName:"Concepcion Berbel"},{id:"71149",title:"Dr.",name:"Manuel",middleName:null,surname:"Manchado",slug:"manuel-manchado",fullName:"Manuel Manchado"},{id:"71151",title:"Dr.",name:"Dolores",middleName:null,surname:"Castro",slug:"dolores-castro",fullName:"Dolores Castro"}]}],mostDownloadedChaptersLast30Days:[{id:"35141",title:"Antibiotics in Aquaculture – Use, Abuse and Alternatives",slug:"antibiotics-in-aquaculture-use-abuse-and-alternatives",totalDownloads:19347,totalCrossrefCites:137,totalDimensionsCites:293,abstract:null,book:{id:"2052",slug:"health-and-environment-in-aquaculture",title:"Health and Environment in Aquaculture",fullTitle:"Health and Environment in Aquaculture"},signatures:"Jaime Romero, Carmen Gloria Feijoo and Paola Navarrete",authors:[{id:"72898",title:"Dr.",name:"Jaime",middleName:null,surname:"Romero",slug:"jaime-romero",fullName:"Jaime Romero"},{id:"79684",title:"Dr.",name:"Paola",middleName:null,surname:"Navarrete",slug:"paola-navarrete",fullName:"Paola Navarrete"},{id:"83411",title:"Dr.",name:"Carmen",middleName:null,surname:"Feijoo",slug:"carmen-feijoo",fullName:"Carmen Feijoo"}]},{id:"69948",title:"Floating Cage: A New Innovation of Seaweed Culture",slug:"floating-cage-a-new-innovation-of-seaweed-culture",totalDownloads:970,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Eucheumatoid cultivation continues to expand with a variety of methods that can increase production. This chapter will discuss an innovation in seaweed cultivation of the genus Eucheuma, which is the prime marine commodity in the tropical regions of the world. Research conducted during 2015-2017 and 2019 in Southeast Sulawesi Province, Indonesia, provided an overview of the use of floating cage that showed very significant growth results. The research result showed that the growth rates of Eucheuma denticulatum and Kappaphycus alvarezii in floating cage seemed faster and resulted in better thallus morphology. Daily production of E. denticulatum and K. alvarezii that were cultivated in floating cage was higher than daily production of E. denticulatum and K. alvarezii cultivated on longline. Specific growth rate (SGR) of E. denticulatum and K. alvarezii cultivated by using floating cage method was also higher than E. denticulatum and K. alvarezii cultivated by using longline method. Moreover, the cultivation by using floating cages produces good growth rates with no effect of herbivore attacks.",book:{id:"8928",slug:"emerging-technologies-environment-and-research-for-sustainable-aquaculture",title:"Emerging Technologies, Environment and Research for Sustainable Aquaculture",fullTitle:"Emerging Technologies, Environment and Research for Sustainable Aquaculture"},signatures:"Ma’ruf Kasim, Abdul Muis Balubi, Ahmad Mustafa, Rahman Nurdin, Rahmad Sofyan Patadjai and Wardha Jalil",authors:[{id:"309893",title:"Prof.",name:"Maruf",middleName:null,surname:"Kasim",slug:"maruf-kasim",fullName:"Maruf Kasim"},{id:"313040",title:"MSc.",name:"Abdul Muis",middleName:null,surname:"Balubi",slug:"abdul-muis-balubi",fullName:"Abdul Muis Balubi"},{id:"313041",title:"MSc.",name:"Wardha",middleName:null,surname:"Jalil",slug:"wardha-jalil",fullName:"Wardha Jalil"},{id:"313042",title:"MSc.",name:"Ahmad",middleName:null,surname:"Mustafa",slug:"ahmad-mustafa",fullName:"Ahmad Mustafa"},{id:"313043",title:"MSc.",name:"Rahman",middleName:null,surname:"Nurdin",slug:"rahman-nurdin",fullName:"Rahman Nurdin"},{id:"313044",title:"MSc.",name:"Rahmat Sofyan",middleName:null,surname:"Patadjai",slug:"rahmat-sofyan-patadjai",fullName:"Rahmat Sofyan Patadjai"}]},{id:"62842",title:"Integrated Rice and Aquaculture Farming",slug:"integrated-rice-and-aquaculture-farming",totalDownloads:1915,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"The burning problems like scarcity of food for ever-growing human population in the present world are addressed by adapting various methods for production of protein, carbohydrate, oils and other food materials. One of the methods to produce high amount of food is integrated farming including rice-aquaculture farming, which produces protein and carbohydrate as major components besides others. Rice-aquaculture farming produces grain (carbohydrate) and animal protein without affecting the quality and quantity of rice yield on the same piece of land and renders additional financial gain besides main crop (rice) like conventional monoculture. The aquatic species grown in the integrated culture are mainly distinct types of fishes, selected crustaceans and other selected species. Profitable rice-aquaculture integrated farming is popular in Asian countries than in Western countries. However, the integrated rice-aquaculture farming has its own limitations. The type of methods, culture species, influencing factors, and pros and cons of rice-aquaculture integrated farming are discussed in the present chapter.",book:{id:"7229",slug:"aquaculture-plants-and-invertebrates",title:"Aquaculture",fullTitle:"Aquaculture - Plants and Invertebrates"},signatures:"Pamuru Ramachandra Reddy and Battina Kishori",authors:[{id:"242524",title:"Dr.",name:"Ramachandra Reddy",middleName:null,surname:"Pamuru",slug:"ramachandra-reddy-pamuru",fullName:"Ramachandra Reddy Pamuru"},{id:"255022",title:"Dr.",name:"Kishori",middleName:null,surname:"Battina",slug:"kishori-battina",fullName:"Kishori Battina"}]},{id:"24074",title:"Embryonic and Larval Development of Freshwater Fish",slug:"embryonic-and-larval-development-of-freshwater-fish",totalDownloads:7462,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"612",slug:"recent-advances-in-fish-farms",title:"Recent Advances in Fish Farms",fullTitle:"Recent Advances in Fish Farms"},signatures:"Faruk Aral, Erdinç Şahınöz and Zafer Doğu",authors:[{id:"25600",title:"Prof.",name:"Faruk",middleName:null,surname:"Aral",slug:"faruk-aral",fullName:"Faruk Aral"},{id:"29132",title:"Dr.",name:"Zafer",middleName:null,surname:"Dogu",slug:"zafer-dogu",fullName:"Zafer Dogu"},{id:"39952",title:"Dr.",name:"Erdinc",middleName:null,surname:"Sahinoz",slug:"erdinc-sahinoz",fullName:"Erdinc Sahinoz"}]},{id:"68966",title:"Novel Biofloc Technology (BFT) for Ammonia Assimilation and Reuse in Aquaculture In Situ",slug:"novel-biofloc-technology-bft-for-ammonia-assimilation-and-reuse-in-aquaculture-in-situ",totalDownloads:1948,totalCrossrefCites:2,totalDimensionsCites:8,abstract:"Ammonia is one of the most harmful risks for success of fish and shrimp culture. There is no effective solution for harmlessness of ammonia in traditional aquaculture operations except exchanging water, which would bring negative effects on environment, or fixing expensive equipment. Biofloc technology (BFT) that appeared in recent years supplies a novel solution for this issue without exchanging huge water and fixing equipment. This technology could assimilate ammonia almost in real time with many other supplemental benefits. Because of the very high nutritional value for fish and shrimp, bioflocs, the by-product of BFT, could also be reused as a complemented food in situ or a gradient for feedstuff to replace expensive fishmeal or be processed to pellet diet to feed fish and shrimp directly. However, some aspects with regard to the effective use of biofloc as a food source for fish and shrimp, such as high lipid content, productivity, and palatability, need to be further researched in detail.",book:{id:"8928",slug:"emerging-technologies-environment-and-research-for-sustainable-aquaculture",title:"Emerging Technologies, Environment and Research for Sustainable Aquaculture",fullTitle:"Emerging Technologies, Environment and Research for Sustainable Aquaculture"},signatures:"Hai-Hong Huang",authors:[{id:"305215",title:"Dr.",name:"Hai-Hong",middleName:null,surname:"Huang",slug:"hai-hong-huang",fullName:"Hai-Hong Huang"}]}],onlineFirstChaptersFilter:{topicId:"32",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:18,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He is on the editorial board of several international peer-reviewed journals and has published many papers. Additionally, he has participated in many international and national congresses, seminars, and workshops with oral and poster presentations. He is an active member of many local and international organizations.",institutionString:"İskenderun Technical University",institution:{name:"İskenderun Technical University",country:{name:"Turkey"}}},{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",biography:"Dr. Sergey Tkachev is a senior research scientist at the Institute of Fundamental Medicine and Biology, Kazan Federal University, Russia, and at the Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia. He received his Ph.D. in Molecular Biology with his thesis “Genetic variability of the tick-borne encephalitis virus in natural foci of Novosibirsk city and its suburbs.” His primary field is molecular virology with research emphasis on vector-borne viruses, especially tick-borne encephalitis virus, Kemerovo virus and Omsk hemorrhagic fever virus, rabies virus, molecular genetics, biology, and epidemiology of virus pathogens.",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",country:{name:"Russia"}}},{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",biography:"Amlan K. Patra, FRSB, obtained a Ph.D. in Animal Nutrition from Indian Veterinary Research Institute, India, in 2002. He is currently an associate professor at West Bengal University of Animal and Fishery Sciences. He has more than twenty years of research and teaching experience. He held previous positions at the American Institute for Goat Research, The Ohio State University, Columbus, USA, and Free University of Berlin, Germany. His research focuses on animal nutrition, particularly ruminants and poultry nutrition, gastrointestinal electrophysiology, meta-analysis and modeling in nutrition, and livestock–environment interaction. He has authored around 175 articles in journals, book chapters, and proceedings. Dr. Patra serves on the editorial boards of several reputed journals.",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",country:{name:"India"}}},{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",biography:"László Babinszky is Professor Emeritus, Department of Animal Nutrition Physiology, University of Debrecen, Hungary. He has also worked in the Department of Animal Nutrition, University of Wageningen, Netherlands; the Institute for Livestock Feeding and Nutrition (IVVO), Lelystad, Netherlands; the Agricultural University of Vienna (BOKU); the Institute for Animal Breeding and Nutrition, Austria; and the Oscar Kellner Research Institute for Animal Nutrition, Rostock, Germany. In 1992, Dr. Babinszky obtained a Ph.D. in Animal Nutrition from the University of Wageningen. His main research areas are swine and poultry nutrition. He has authored more than 300 publications (papers, book chapters) and edited four books and fourteen international conference proceedings.",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"201830",title:"Dr.",name:"Fernando",middleName:"Sanchez",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201830/images/5017_n.jpg",biography:"I am a professor at UANL since 1988. My research lines are the development of reproductive techniques in small ruminants. We also conducted research on sexual and social behavior in males.\nI am Mexican and study my professional career as an engineer in agriculture and animal science at UANL. Then take a masters degree in science in Germany (Animal breeding). Take a doctorate in animal science at the UANL.",institutionString:null,institution:{name:"Universidad Autónoma de Nuevo León",country:{name:"Mexico"}}},{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. He works as a Senior Clinician at the Veterinary Teaching Hospital of UTAD (HVUTAD) with a role in clinical activity in the area of livestock and equine species as well as to support teaching and research in related areas. He teaches as an Invited Professor in Reproduction Medicine I and II of the Master\\'s in Veterinary Medicine degree at UTAD. Currently, he holds the position of Chairman of the Portuguese Buiatrics Association. He is a member of the Consultive Group on Production Animals of the OMV. He has 19 publications in indexed international journals (ISIS), as well as over 60 publications and oral presentations in both Portuguese and international journals and congresses.",institutionString:"University of Trás-os-Montes and Alto Douro",institution:{name:"University of Trás-os-Montes and Alto Douro",country:{name:"Portugal"}}},{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"283019",title:"Dr.",name:"Oudessa",middleName:null,surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/283019/images/system/283019.png",biography:"Dr. Kerro Dego is a veterinary microbiologist with training in veterinary medicine, microbiology, and anatomic pathology. Dr. Kerro Dego is an assistant professor of dairy health in the department of animal science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. He received his D.V.M. (1997), M.S. (2002), and Ph.D. (2008) degrees in Veterinary Medicine, Animal Pathology and Veterinary Microbiology from College of Veterinary Medicine, Addis Ababa University, Ethiopia; College of Veterinary Medicine, Utrecht University, the Netherlands and Western College of Veterinary Medicine, University of Saskatchewan, Canada respectively. He did his Postdoctoral training in microbial pathogenesis (2009 - 2015) in the Department of Animal Science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. Dr. Kerro Dego’s research focuses on the prevention and control of infectious diseases of farm animals, particularly mastitis, improving dairy food safety, and mitigation of antimicrobial resistance. Dr. Kerro Dego has extensive experience in studying the pathogenesis of bacterial infections, identification of virulence factors, and vaccine development and efficacy testing against major bacterial mastitis pathogens. Dr. Kerro Dego conducted numerous controlled experimental and field vaccine efficacy studies, vaccination, and evaluation of immunological responses in several species of animals, including rodents (mice) and large animals (bovine and ovine).",institutionString:"University of Tennessee at Knoxville",institution:{name:"University of Tennessee at Knoxville",country:{name:"United States of America"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",country:{name:"Spain"}}},{id:"309529",title:"Dr.",name:"Albert",middleName:null,surname:"Rizvanov",slug:"albert-rizvanov",fullName:"Albert Rizvanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309529/images/9189_n.jpg",biography:'Albert A. Rizvanov is a Professor and Director of the Center for Precision and Regenerative Medicine at the Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU), Russia. He is the Head of the Center of Excellence “Regenerative Medicine” and Vice-Director of Strategic Academic Unit \\"Translational 7P Medicine\\". Albert completed his Ph.D. at the University of Nevada, Reno, USA and Dr.Sci. at KFU. He is a corresponding member of the Tatarstan Academy of Sciences, Russian Federation. Albert is an author of more than 300 peer-reviewed journal articles and 22 patents. He has supervised 11 Ph.D. and 2 Dr.Sci. dissertations. Albert is the Head of the Dissertation Committee on Biochemistry, Microbiology, and Genetics at KFU.\nORCID https://orcid.org/0000-0002-9427-5739\nWebsite https://kpfu.ru/Albert.Rizvanov?p_lang=2',institutionString:"Kazan Federal University",institution:{name:"Kazan Federal University",country:{name:"Russia"}}},{id:"210551",title:"Dr.",name:"Arbab",middleName:null,surname:"Sikandar",slug:"arbab-sikandar",fullName:"Arbab Sikandar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210551/images/system/210551.jpg",biography:"Dr. Arbab Sikandar, PhD, M. Phil, DVM was born on April 05, 1981. He is currently working at the College of Veterinary & Animal Sciences as an Assistant Professor. He previously worked as a lecturer at the same University. \nHe is a Member/Secretory of Ethics committee (No. CVAS-9377 dated 18-04-18), Member of the QEC committee CVAS, Jhang (Regr/Gen/69/873, dated 26-10-2017), Member, Board of studies of Department of Basic Sciences (No. CVAS. 2851 Dated. 12-04-13, and No. CVAS, 9024 dated 20/11/17), Member of Academic Committee, CVAS, Jhang (No. CVAS/2004, Dated, 25-08-12), Member of the technical committee (No. CVAS/ 4085, dated 20,03, 2010 till 2016).\n\nDr. Arbab Sikandar contributed in five days hands-on-training on Histopathology at the Department of Pathology, UVAS from 12-16 June 2017. He received a Certificate of appreciation for contributions for Popularization of Science and Technology in the Society on 17-11-15. He was the resource person in the lecture series- ‘scientific writing’ at the Department of Anatomy and Histology, UVAS, Lahore on 29th October 2015. He won a full fellowship as a principal candidate for the year 2015 in the field of Agriculture, EICA, Egypt with ref. to the Notification No. 12(11) ACS/Egypt/2014 from 10 July 2015 to 25th September 2015.; he received a grant of Rs. 55000/- as research incentives from Director, Advanced Studies and Research, UVAS, Lahore upon publications of research papers in IF Journals (DR/215, dated 19-5-2014.. He obtained his PhD by winning a HEC Pakistan indigenous Scholarship, ‘Ph.D. fellowship for 5000 scholars – Phase II’ (2av1-147), 17-6/HEC/HRD/IS-II/12, November 15, 2012. \n\nDr. Sikandar is a member of numerous societies: Registered Veterinary Medical Practitioner (life member) and Registered Veterinary Medical Faculty of Pakistan Veterinary Medical Council. The Registration code of PVMC is RVMP/4298 and RVMF/ 0102.; Life member of the University of Veterinary and Animal Sciences, Lahore, Alumni Association with S# 664, dated: 6-4-12. ; Member 'Vets Care Organization Pakistan” with Reference No. VCO-605-149, dated 05-04-06. :Member 'Vet Crescent” (Society of Animal Health and Production), UVAS, Lahore.",institutionString:"University of Veterinary & Animal Science",institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311663/images/13261_n.jpg",biography:null,institutionString:null,institution:{name:"National Dairy Research Institute",country:{name:"India"}}},{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",country:{name:"United Kingdom"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",biography:"Samir El-Gendy is a Professor of anatomy and embryology at the faculty of veterinary medicine, Alexandria University, Egypt. Samir obtained his PhD in veterinary science in 2007 from the faculty of veterinary medicine, Alexandria University and has been a professor since 2017. Samir is an author on 24 articles at Scopus and 12 articles within local journals and 2 books/book chapters. His research focuses on applied anatomy, imaging techniques and computed tomography. Samir worked as a member of different local projects on E-learning and he is a board member of the African Association of Veterinary Anatomists and of anatomy societies and as an associated author at local and international journals. Orcid: https://orcid.org/0000-0002-6180-389X",institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"246149",title:"Dr.",name:"Valentina",middleName:null,surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246149/images/system/246149.jpg",biography:"Valentina Kubale is Associate Professor of Veterinary Medicine at the Veterinary Faculty, University of Ljubljana, Slovenia. Since graduating from the Veterinary faculty she obtained her PhD in 2007, performed collaboration with the Department of Pharmacology, University of Copenhagen, Denmark. She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. She is a member of Slovenian Biochemical Society, The Endocrine Society, European Association of Veterinary Anatomists and Society for Laboratory Animals, where she is board member.",institutionString:"University of Ljubljana",institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",biography:"Dr. Fonseca-Alves earned his DVM from Federal University of Goias – UFG in 2008. He completed an internship in small animal internal medicine at UPIS university in 2011, earned his MSc in 2013 and PhD in 2015 both in Veterinary Medicine at Sao Paulo State University – UNESP. Dr. Fonseca-Alves currently serves as an Assistant Professor at Paulista University – UNIP teaching small animal internal medicine.",institutionString:null,institution:{name:"Universidade Paulista",country:{name:"Brazil"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",biography:"María de la Luz García Pardo is an agricultural engineer from Universitat Politècnica de València, Spain. She has a Ph.D. in Animal Genetics. Currently, she is a lecturer at the Agrofood Technology Department of Miguel Hernández University, Spain. Her research is focused on genetics and reproduction in rabbits. The major goal of her research is the genetics of litter size through novel methods such as selection by the environmental sensibility of litter size, with forays into the field of animal welfare by analysing the impact on the susceptibility to diseases and stress of the does. Details of her publications can be found at https://orcid.org/0000-0001-9504-8290.",institutionString:null,institution:{name:"Miguel Hernandez University",country:{name:"Spain"}}},{id:"350704",title:"M.Sc.",name:"Camila",middleName:"Silva Costa",surname:"Ferreira",slug:"camila-ferreira",fullName:"Camila Ferreira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/350704/images/17280_n.jpg",biography:"Graduated in Veterinary Medicine at the Fluminense Federal University, specialist in Equine Reproduction at the Brazilian Veterinary Institute (IBVET) and Master in Clinical Veterinary Medicine and Animal Reproduction at the Fluminense Federal University. She has experience in analyzing zootechnical indices in dairy cattle and organizing events related to Veterinary Medicine through extension grants. I have experience in the field of diagnostic imaging and animal reproduction in veterinary medicine through monitoring and scientific initiation scholarships. I worked at the Equus Central Reproduction Equine located in Santo Antônio de Jesus – BA in the 2016/2017 breeding season. I am currently a doctoral student with a scholarship from CAPES of the Postgraduate Program in Veterinary Medicine (Pathology and Clinical Sciences) at the Federal Rural University of Rio de Janeiro (UFRRJ) with a research project with an emphasis on equine endometritis.",institutionString:null,institution:null},{id:"41319",title:"Prof.",name:"Lung-Kwang",middleName:null,surname:"Pan",slug:"lung-kwang-pan",fullName:"Lung-Kwang Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41319/images/84_n.jpg",biography:null,institutionString:null,institution:null},{id:"125292",title:"Dr.",name:"Katy",middleName:null,surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/125292/images/system/125292.jpeg",biography:"Katy Satué Ambrojo received her Veterinary Medicine degree, Master degree in Equine Technology and doctorate in Veterinary Medicine from the Faculty of Veterinary, CEU-Cardenal Herrera University in Valencia, Spain.Dr. Satué is accredited as a Private University Doctor Professor, Doctor Assistant, and Contracted Doctor by AVAP (Agència Valenciana d'Avaluació i Prospectiva) and currently, as a full professor by ANECA (since January 2022). To date, Katy has taught 22 years in the Department of Animal Medicine and Surgery at the CEU-Cardenal Herrera University in undergraduate courses in Veterinary Medicine (General Pathology, integrated into the Applied Basis of Veterinary Medicine module of the 2nd year, Clinical Equine I of 3rd year, and Equine Clinic II of 4th year). Dr. Satué research activity is in the field of Endocrinology, Hematology, Biochemistry, and Immunology in the Spanish Purebred mare. She has directed 5 Doctoral Theses and 5 Diplomas of Advanced Studies, and participated in 11 research projects as a collaborating researcher. She has written 2 books and 14 book chapters in international publishers related to the area, and 68 scientific publications in international journals. Dr. Satué has attended 63 congresses, participating with 132 communications in international congresses and 19 in national congresses related to the area. Dr. Satué is a scientific reviewer for various prestigious international journals such as Animals, American Journal of Obstetrics and Gynecology, Veterinary Clinical Pathology, Journal of Equine Veterinary Science, Reproduction in Domestic Animals, Research Veterinary Science, Brazilian Journal of Medical and Biological Research, Livestock Production Science and Theriogenology, among others. Since 2014 she has been responsible for the Clinical Analysis Laboratory of the CEU-Cardenal Herrera University Veterinary Clinical Hospital.",institutionString:null,institution:null},{id:"201721",title:"Dr.",name:"Beatrice",middleName:null,surname:"Funiciello",slug:"beatrice-funiciello",fullName:"Beatrice Funiciello",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201721/images/11089_n.jpg",biography:"Graduated from the University of Milan in 2011, my post-graduate education included CertAVP modules mainly on equines (dermatology and internal medicine) and a few on small animal (dermatology and anaesthesia) at the University of Liverpool. After a general CertAVP (2015) I gained the designated Certificate in Veterinary Dermatology (2017) after taking the synoptic examination and then applied for the RCVS ADvanced Practitioner status. After that, I completed the Postgraduate Diploma in Veterinary Professional Studies at the University of Liverpool (2018). My main area of work is cross-species veterinary dermatology.",institutionString:null,institution:null},{id:"291226",title:"Dr.",name:"Monica",middleName:null,surname:"Cassel",slug:"monica-cassel",fullName:"Monica Cassel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/291226/images/8232_n.jpg",biography:'Degree in Biological Sciences at the Federal University of Mato Grosso with scholarship for Scientific Initiation by FAPEMAT (2008/1) and CNPq (2008/2-2009/2): Project \\"Histological evidence of reproductive activity in lizards of the Manso region, Chapada dos Guimarães, Mato Grosso, Brazil\\". Master\\\'s degree in Ecology and Biodiversity Conservation at Federal University of Mato Grosso with a scholarship by CAPES/REUNI program: Project \\"Reproductive biology of Melanorivulus punctatus\\". PhD\\\'s degree in Science (Cell and Tissue Biology Area) \n at University of Sao Paulo with scholarship granted by FAPESP; Project \\"Development of morphofunctional changes in ovary of Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae)\\". She has experience in Reproduction of vertebrates and Morphology, with emphasis in Cellular Biology and Histology. She is currently a teacher in the medium / technical level courses at IFMT-Alta Floresta, as well as in the Bachelor\\\'s degree in Animal Science and in the Bachelor\\\'s degree in Business.',institutionString:null,institution:null},{id:"442807",title:"Dr.",name:"Busani",middleName:null,surname:"Moyo",slug:"busani-moyo",fullName:"Busani Moyo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gwanda State University",country:{name:"Zimbabwe"}}},{id:"439435",title:"Dr.",name:"Feda S.",middleName:null,surname:"Aljaser",slug:"feda-s.-aljaser",fullName:"Feda S. 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Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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