\r\n\tThere will be a chapter on secondary causes of sexual dysfunction disorders related to diabetes, cardiovascular disease, and obesity. A chapter on remedial measures to enhance sexual activity and maintain human relationships will be discussed. As there is a growing number of cancer survivors a chapter on cancer-related sexual dysfunction will be welcomed for including it.
",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"b988fda30a4e2364ee9d47e417bd0ba9",bookSignature:"Dr. Dhastagir Sultan Sheriff",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11889.jpg",keywords:"Sex, Sexual Response Cycle, Erection, Premature Ejaculation, Libido, Orgasm, Painful Intercourse, Psychological, Female, Lack of Desire, Erectile Disorders, Pain Disorders",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 8th 2022",dateEndSecondStepPublish:"May 6th 2022",dateEndThirdStepPublish:"July 5th 2022",dateEndFourthStepPublish:"September 23rd 2022",dateEndFifthStepPublish:"November 22nd 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dhastagir Sultan Sheriff is a life member of the European Society for Human Reproduction and Early Human Development, Association of Physiologists and Pharmacologists of India, member of the National Academy of Medical Sciences, New Delhi, and resource person for UNESCO for Medical and Bioethics. Dr. Sheriff has authored five books including a textbook on medical biochemistry with additional interest in human sexology. He has done extensive research in andrology, sex education, and counseling.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"167875",title:"Dr.",name:"Dhastagir Sultan",middleName:null,surname:"Sheriff",slug:"dhastagir-sultan-sheriff",fullName:"Dhastagir Sultan Sheriff",profilePictureURL:"https://mts.intechopen.com/storage/users/167875/images/system/167875.jpg",biography:"Dhastagir Sultan Sheriff is a life member of the European Society for Human Reproduction and Early Human Development, Association of Physiologists and Pharmacologists of India, member of the National Academy of Medical Sciences, New Delhi, and resource person for UNESCO for Medical and Bioethics. Dr. Sheriff has authored five books including a textbook on medical biochemistry with additional interest in human sexology. He had editorials written in the British Journal of Sexology, Journal of Royal Society of Medicine, Postgraduate Medicine, and Scientist. He was a former Rotarian, Citizen Ambassador, and was selected for the Ford Foundation Fellowship.",institutionString:"University of Benghazi",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Benghazi",institutionURL:null,country:{name:"Libya"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:null},relatedBooks:[{type:"book",id:"6934",title:"Psycho-Social Aspects of Human Sexuality and Ethics",subtitle:null,isOpenForSubmission:!1,hash:"44731b106aa0d1ab5c64a7394483c7d5",slug:"psycho-social-aspects-of-human-sexuality-and-ethics",bookSignature:"Dhastagir Sultan Sheriff",coverURL:"https://cdn.intechopen.com/books/images_new/6934.jpg",editedByType:"Edited by",editors:[{id:"167875",title:"Dr.",name:"Dhastagir Sultan",surname:"Sheriff",slug:"dhastagir-sultan-sheriff",fullName:"Dhastagir Sultan Sheriff"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7163",title:"Infertility, Assisted Reproductive Technologies and Hormone Assays",subtitle:null,isOpenForSubmission:!1,hash:"6db6e4ccb7088f17f819121f7eb6424d",slug:"infertility-assisted-reproductive-technologies-and-hormone-assays",bookSignature:"Dhastagir Sultan Sheriff",coverURL:"https://cdn.intechopen.com/books/images_new/7163.jpg",editedByType:"Edited by",editors:[{id:"167875",title:"Dr.",name:"Dhastagir Sultan",surname:"Sheriff",slug:"dhastagir-sultan-sheriff",fullName:"Dhastagir Sultan Sheriff"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. 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The efficiency of a converter should be excellent. The components constituting a converter are:
Capacitors, inductors and transformers with minimum losses,
Power semiconductors operating as switches.
The design of power converter consumes time with a significant cost. Performance is generally determined after testing converters at nominal operating points. Thus, simulation can substantially reduce development cost.
The development of specific software dedicated to simulation of power electronic systems (PSIM, SABER, PSCAD, “SimPowerSystems” toolbox of Simulink…) allows simulating fast and accurately the converter behavior. Unfortunately, the designers of converters don’t always have such available software. In many cases, they have to simulate power electronics devices for occasional need. So they don\'t want to buy the SimPowerSystems toolbox in addition to Matlab and Simulink. The purpose of this chapter is to present the ability to simulate power converters using only Simulink. Simulink is a graphical extension to MATLAB for representing mathematical functions and systems in the form of block diagram, and simulate the operation of these systems.
Traditionally two approaches are used to simulate power electronic systems:
The first, so called fixed topology, where semiconductors are impedances with low or high values based on their on-state or off-state. Equations system does not depend on the state of the semiconductor. Despite its simplicity, this approach raises problems of compromise between accuracy of the results and stability of numerical integration methods.
The second, so called variable topology, assimilates the switches to open-circuits or short-circuits. The system equations then depend on the state of the semiconductor. There are no accuracy problems but writing the equations of different configurations can be laborious as well as obtain switching conditions of the semiconductor.
In this chapter, we propose a method for simulating static converters with Simulink based on the variable topology approach where switching conditions of semiconductor are realized by switching functions.
This paragraph deals with the modelling of linear elements commonly encountered in the electrical energy conversion. Elementary linear dipoles are described by a system of linear differential equations. There are several different ways to describe linear differential equations. The state-space representation (SSR) is the most easy to use with Matlab. The SSR is given by equations (1) and (2).
where X is an n by 1 vector representing the state (commonly current through an inductance or voltage across the capacitance ), U is a scalar representing the input (voltage or current), and Y is a scalar representing the output. The matrices A (n by n), B (n by 1), and C (1 by n) determine the relationships between the state and input and output variables.
The commonly elementary dipoles encountered in power electronics are:
RL series dipole
RLC series dipole
RC parallel dipole
L in series with RC parallel dipole
The variation of the current through the dipole is governed by equation (3).
The RL series dipole is modelled by the scheme illustrated in figure 1.
The variation of the current through the dipole is governed by equation (4) and the variation of the voltage across the capacity is governed by equation (5).
Model of a RL series dipole
The RLC series dipole is modelled by the scheme illustrated in figure 2.
Model of a RLC series dipole
The variation of the voltage across the dipole is governed by equation (6).
The RC parallel dipole is modelled by the scheme illustrated in figure 3.
In a L in series with RC parallel dipole, the variation of the current through the inductance is governed by equation (7) and the variation of the voltage across the capacity is governed by equation (8).
The L in series with RC parallel dipole is modelled by the scheme illustrated in figure 4.
Model of a RC parallel dipole
Model of a L in series with RC parallel dipole
This part will be dedicated to the DC-DC converter modelling with Simulink. The input generator is a DC voltage source and the output generator is also a DC voltage source. The output voltage is always smoothed by a capacitor. Only the non-isolated DC-DC converters are studied in this paragraph. The switches are assumed ideal, as well as passive elements (L, C)
The buck converter circuit is illustrated in figure 5a. The most common strategy for controlling the power transmitted to the load is the intersective Pulse Width Modulation (PWM). A control voltage vm is compared to a triangular voltage vt. The triangular voltage vt determines the switching frequency ft. The switch T is controlled according to the difference vm – vt (figure 5b). Three operating phases are counted (figure 5c):
T state-on and D state-off
T state-off and D state-on
T and D state-off
Buck converter
The variation of the current through the capacitor C is governed by equation (10). The variation of the voltage across the capacity is governed by equation (11). Equation (12) describes the variation of the voltage across the inductance which depends on the operating phase. F is a logical variable equal to one if vm is greater than or equal to vt, F equal to zero if vm is less than vt. Sign(iL) is also a logical variable which is equal to one if iL is positive, sign (iL) equal to zero if iL is zero.
Simulink model of the open-loop buck converter is shown in figure 6 a. The Buck block is illustrated in figure 6 c. Equation (12) is modelled by blocks addition, multiplication and logic. The structure of the converter requires a current iL necessarily positive or zero. Also, the inductance current is modelled by an integrator block that limits the minimum value of iL to zero.
The PWM control block is illustrated in figure 6 b.
In the case of a resistive load, the load block is constituted by a gain block (value 1/R).
Buck converter described in Simulink
A closed-loop buck converter circuit is illustrated in figure 7 a. The measurement of the output voltage is realized by 2 resistances R1 and R2. The regulation is achieved by a PID controller. Simulink model of the closed loop converter is shown in figure 7 b. Simulink PID control block is illustrated in figure 7 c.
The parameters used for the closed-loop simulation are :
Vi = 12 V | L = 300 H | C = 5 F | R = 3 | ft = 50 kHz | ||
Output voltage measurement: | R1 = 10 k | R2 = 10 k | ||||
PID block : | Kp = 10 | Ti = 0.2 ms |
The voltage reference was fixed to 2.5 V. The simulation of the closed-loop buck converter is illustrated in figure 7 d. The list of configuration parameters used for is:
Modeling a closed loop DC / DC converter
In steady-state, Vref = Vmes = 2.5 V. From figure 7a, we deduce the theoretical value of Vo:
Simulation is in good agreement with theoretical value. From figure 7d, we deduce that the transient state last roughly 0.2 ms.
The boost converter circuit is illustrated in figure 8 a. The principle of the switch control is described in figure 5b Three operating phases are counted (figure 8c) :
T state-on and D state-off
T state-off and D state-on
T and D state-off
The variation of the voltage across the inductance L (equation 14) and the current through the capacity (equation 15) depend on the operating phase.
Simulink model of a open-loop boost converter is shown in figure 9a. The Boost block is illustrated in figure 9b. Equation (14), (15) and (16) are modeled by addition blocks, multiplication blocks and logic blocks. The structure of the converter requires a current iL necessarily positive or zero. Also, the inductance current is modeled by an integrator block that limits the minimum value of iL to zero.
The PWM control block is illustrated in figure 6 b.
In the case of a resistive load, the load block is constituted by a gain block (value 1/R).
Simulation example:
The parameters used for of an open-loop simulation are :
Vi = 12 V | L = 200 H | C = 50 F | R = 5 | ft = 50 kHz | |||
Control blok: | Vm = 0 |
The simulation of the open-loop boost converter is illustrated in figure 9 c. The list of configuration parameters used is:
Knowing that vt varies from – 1 V to + 1 V and vm = 0, we deduce that the duty cycle is equal to 0.5. In steady-state, we deduce theoretical value of Vo :
Simulation is in good agreement with theoretical value. From figure 9c, we deduce that the transient state last roughly 2.5 ms.
Boost converter
Boost converter described in Simulink
An inverter is a DC – AC power converter. This converter obtains AC voltage from DC voltage. The applications are numerous: power backup for the computer systems, variable speed drive motor, induction heating... In most cases, the dead times introduced into the control of the switches do not change the waveform of the inverter.
This paragraph is dedicated to the simulation of a three-phase inverter without taking into account the dead times introduced into the control of the switches.
A variable speed drive for AC motor is shown in figure 10. It consists on a continuous voltage source and a three-phase inverter feeding an AC motor.
In order to simplify the modelling, the electrical equivalent circuit of the AC motor is described by an inductance LM in series with a resistance RM. The motor runs with delta connection of the stator.
Electrical circuit
There are many strategies for controlling the switches. The most common control strategy is the intersective PWM. Its principle is reminded in figure 11. The switch control signals are generated by comparing three sinusoidal voltages (modulating) which are phase-shifted through 2/3 [rad] with a same triangular voltage waveform (carrier).
Three phase PWM control
Knowing the conduction intervals of the switches, it is then possible to determine the waveform of different voltages and currents.
The line to neutral voltage v10, v20 et v30 are dependent on the state of the switches. Examples:
The phase-phase voltage can be deduce from the line to neutral voltage:
u12 = v10 – v20\n\t\t\t\t
u23 = v20 – v30\n\t\t\t\t
u31 = v30 – v10\n\t\t\t\t
The input current ii is deduced from the current of switches K1, K3 and K5:
Simulink model of the three-phase inverter is shown in figure 12 a. The control block is illustrated in figure 12 b. It models a three phases PWM control. The inverter block is illustrated in figure 12 c.
In the case of a resistive load, the load block is constituted by a gain block (value 1/R).
The parameters used for of an open-loop simulation are :
Power Circuit : | VDC = 400 V | LM = 10 mH | RM = 5 |
Control blok: | ft = 20 kHz | Vt max = 1 V | Vt min = - 1 V |
fm = 50 Hz | Vm max = 0.5 |
The simulation of the open-loop three-phase inverter is illustrated in figure 13. The list of configuration parameters used is:
The relation between the amplitude of the sinusoidal voltage and the triangular voltage determines the maximum value of the fundamental line-line voltage of the inverter:
Neglecting the current harmonics, the maximum value of the line current is deduced from equation (22) :
Simulations are in good agreement with theoretical values.
Three phase inverter
Simulation example of a three-phase inverter with PWM control
Three-phase AC to DC converters are widely used in many industrial power converters in order to obtain continuous voltage using a classical three-phase AC-line. These converters, when they are used alone or associated for specific applications, can present problems due to their non-linear behaviour. It is then important to be able to model accurately the behaviour of these converters in order to study their influence on the input currents waveforms and their interactions with the loads (classically inverters and AC-motors).
Several studies have shown the importance to have tools to simulate the behaviour of complex power electronics systems (Ladoux et al., 2005), (Qijun et al. 2007), (Zuniga-Haro & Ramirez, 2009) and several methods have been also presented in order to reduce the simulation time or to improve the precision. Although constant topology methods have been developed (Araujo et al., 2002), variable topology methods seem to be very suitable for simulation of power-electronics converters (Terrien et al., 1999).
In this chapter, an original and simple method is developed to model and simulate AC-DC converters taking into account overlap phenomenon with continuous and discontinuous conduction modes using Matlab-Simulink. The diodes are assumed ideal (vd = 0 when the diode is state-on, id = 0 when the diode is state-off)
If the electrical network is considered as ideal (no line inductance) and the conduction is maintained continuous, (id>0), the modelling of the converters can be realised very simply by a functional approach (commutation functions) where the switches are opened or closed. An example is presented in figure 14.
Basic model of a single-phase rectifier.
In this chapter, the proposed approach is completely different from the approach based on commutation functions. It permits to simulate accurately the commutation in the six-pulse AC-DC converter, even under unbalanced supply voltages (the influence of voltages unbalances on AC harmonic magnitudes currents has been demonstrated (de Oliveira & Guimaraes, 2007) or line impedances conditions.
The overlap phenomenon and the unbalance of line impedances can be taken into account by modifying the commutation functions to correspond to the real behaviour of the rectifiers in these conditions. Indeed, the commutations are not instantaneous. Several contributions have already been proposed in scientific literature to refine the modelling of rectifiers. Most of these contributions show good simulation results but the analytical models used are complex and not reflecting precisely the real behaviour of the converter (Hu & Morrison, 1997), (Arrillaga et al., 1997). Some methods have been developed in order to model and simulate power factor corrected single-phase AC-DC converters (Pandey et al., 2004).
The six-pulse AC-DC converter is illustrated in figure 15a. Inductances Li characterize the line inductances and Lo characterizes the output inductance. The AC-DC converter modelling is based on the variable topology approach. The diodes are modelled by an ideal model which traduces the state of the switch:
vD = 0 when the diode is state-on;
iD = 0 when the diode is state-off.
There are 13 operating phases:
1 phase of discontinuous conduction mode (P0)
All the diodes are state-off (figure 15b)
6 phases of classical conduction P1 to P6 (figure 15c)
6 phases of overlap O1 to O6 (figure 15d)
Six-pulse diode rectifier.
Naturally, the method is equivalent under unbalanced conditions but the mathematical expressions of the different variables are more complex.
As an example, we will consider the following succession of phases: P0, P1, O1, P2, O2, P3…:
To shift from phase P0 (diodes state-off) to phase P1 (D1 D5 state-on), the voltage across diodes D1 and D5 have to be equal to zero.
To shift from phase P1 (D1 D5 state-on) to overlap phase O1 (D1 D5 D6 state-on), the voltage across the diode D6 has to be equal to zero.
To shift from overlap phase O1 (D1 D5 D6 state-on) to phase P2 (D1 D6 state-on), the current through the diode D5 has to be equal to zero.
And so forth …
This mode corresponds to the case where io = 0 (figure 15b). In this case, all diodes are opened. Equation (24) describes this mode.
Let’s take example of the continuous conduction mode P1. From the figure 15c, we can write equations (25), (26) and (27) :
We obtain the di/dt corresponding to the other continuous conduction modes by making circular permutations of indexes. For example, for conduction mode P2: D1 and D6 are state-on. The indexes s and t are permuted as presented below:
Let’s take example of the overlap phase O1. From the figure 15c, we can write equations (30) and (31) :
The expression of the di/dt as a function of the device parameters is more complicated to obtain here than in the case of a classical operating phase. Equations have been detailed in (Batard et al., 2007) and the final result is recalled below:
We obtain the di/dt corresponding to the other overlap modes by making circular permutations of indexes. For example, for overlap mode O2: D1, D2 and D6 are state-on. The indexes r and t are permuted and the sign of vs and dio/dt are changed:
The simulink model of the six-pulse diode rectifier is illustrated in figure 16 a. The resistive load is modelled as a gain. The internal structure of the diodes rectifier block is presented in figure 16 b. Four different blocks can be seen on this scheme.
The first one called MF1 is a Matlab function which computes each diode voltage. The inputs of this block are the initial phase and the three-phase network voltages.
The second one called MF2 is also a Matlab function which computes the new operating phase and each inductance di/dt. Its computing algorithm is shown in figure 16 d. The new operating phase depends on the initial phase, the diode voltages and currents.
The third, called “Initial Phase” extract the operating phase of the MF2 block, this operating phase becomes the initial phase of the next calculation step (the Simulink block "memory" is used).
The Current block computes each diode current which permits to obtain the DC current and the line currents.
Diode rectifier model
The internal structure of the Current block is shown in figure 16 c. The originality of our approach is the calculation of the values of each diode current with the values of di/dt of inductances Li and Lo. We use then six integrator blocks (one for each diode). The integrator blocks are set to limit their minimal output value to zero (lower saturation limit), this feature permits to avoid the problem of accurate determination of the instant when diodes currents reach to zero.
It is then possible to determinate the output current of the rectifier (io = iD1 + iD2 + iD3) and the input line currents (ir = iD1 – iD4, is = iD2 – iD5, it = iD3 – iD6).
Simulations and experimental waveforms related to figure 15 are shown in figure 17. The simulation parameters are adjusted as follows:
URMS = 230 V ; R = 58 ; Li =800 H ; Lo = 800 mH
It can be seen that the simulated waveforms are very close to the experimental ones. The overlap interval 1 is equivalent for simulation and experimental results (1 0.7 ms).
Comparison of Simulation and Experimental Waveforms in a six-pulse diode rectifier
The list of configuration parameters used for Matlab simulation is:
Using a PC with an Intel core 2 duo CPU running at 2.19 GHz with 1 Go de RAM, the simulation time was 4 s.
This model has also been tested with a load constituted of an inverter and an induction machine. The results of this test have validated operations for discontinuous conduction mode. For the same configuration parameters, the simulation time was 5 s.
The Simulink model of the controlled rectifier is very close to the Simulink model of the diode rectifier. Only the condition to turn the thyristor on is different to the condition to turn the diode on. For an ideal thyristor, it is recalled that the thyristor turn-on if its voltage is positive and if a current pulse is sent to the gate.
To illustrate the modelling of controlled rectifier with Simulink, let\'s look at one of the principles of speed control of DC machines.
Let us consider the electrical scheme presented on figure 18 a. It represents a DC motor fed by a six-pulse rectifier. The electrical equivalent circuit of the DC motor is described by an inductance La in series with a resistance Ra in series with an induced voltage Va which characterizes the electromotive force, as illustrated in figure 18 b.
Controlled rectifier with inductive load
The thyristor are modelled by an ideal model which traduces the state of the switch:
VT = 0 when the thyristor is state-on
IT = 0 when the thyristor is state-off
Similar to the diode rectifier, there are 13 operating phases to describe:
1 phase of discontinuous conduction mode (P0)
All the thyristor are state-off
6 phases of classical conduction P1 to P6 (figure 15c)
6 phases of overlap O1 to O6 (figure 15d)
The different operating phases are illustrated in figure 15. The equations that governs an operating phase are the same whatever we work on a diode rectifier or a controlled rectifier.
The simulink model of the controlled rectifier with inductive load is presented in figure 19. It consists of four blocks:
Input Voltage block characterizes the mains supply,
teta_r block models the thyristor control,
Controlled rectifier block computes the different operating phases.
The load block represents the motor resistance Ra and the induced voltage Va.
The motor inductance La is regrouped with the output line inductance Lo to have a single output inductor Loeq.
Simulink model of the controlled rectifier with inductive load
The structure of the rectifier block is presented on figure 20 a. Four different blocks can be seen on this scheme: the first one called “Control T” is used for the control of the thyristor gate. The second one called MF1 is used to compute the inductances state and voltage. The third called Current computes inductances currents. Then, the Initial Phase block computes the initial state for next computing phase.
The computing algorithm has been created in accordance with figure 20 b. For each computing step, the new operating phase is calculated. This phase is a function of the initial phase, the sign of the inductance currents and the diode voltages. For each operating phase, the value of each inductance di/dt is calculated and permits to know the diodes currents with the integrator function.
The current block is strictly identical to the current block shown in figure 16.
The control device for thyristor T1 is presented in figure 21. The switch-on of T1 is delayed of r after urt has reached to zero (block "Delay 1"). The control thus carried out is a pulse train (the width of a pulse is computed by block "Delay 2").
The same principle is applied to the other thyristor.
Structure of the rectifier block
Simulations and experimental waveforms related to the electrical circuit presented in figure 18 are shown in figure 22. The simulation parameters are adjusted as follows:
URMS = 230 V ; Ra = 4 ; Va = 145 V; Li = 800 H ; Loeq = 800 mH
The list of configuration parameters used for Matlab simulation is:
Control of thyristor T1
Comparison of Simulation and Experimental Waveforms
We can see that simulation results are in good agreement with experimental waveforms. The overlap delays are equivalent for simulation and experimental results.
This chapter has shown that it is possible to simulate many electrical power converters only using Simulink toolbox of Matlab, thus avoiding the purchase of expensive and complex dedicated software. The simulation method is based on the variable topology approach where switching conditions of semiconductor are realized by switching functions.
The first part of this chapter is dedicated to the modelling of linear loads: RL series, RLC series and L in series with RC parallel dipoles are considered. The second part deals with the simulation of DC-DC converters. The buck converter is first studied: after describing the operating phases, open-loop and closed-loop models are presented. A simulation is realised for closed-loop model showing good agreement with theoretical values. The third part shows how to model three-phases DC-AC converters. The electrical circuit and his complete Simulink model are presented and simulation results on RL series load with PWM control are shown. The fourth part presents the modelling of a six-pulse AC-DC converter which is frequently used in industrial applications. The complete model of this converter and his Simulink equivalent circuit are accurately described taking into account overlap phenomenon. A simulation result on RL series load is presented and compared to experimental result. The similarity of the two results shows the validity of the proposed model. The fifth part extends the method to controlled rectifier. The structure studied here is a six-pulse thyristor rectifier feeding a DC motor. The difference with the diode rectifier is presented with the introduction of a thyristor control block in the simulation. Simulations results are showed in continuous condition mode and are in good agreement with experimental results.
Many of the results presented in this chapter are computed with short simulation times (few seconds). This can be achieved thanks to the simplicity of the proposed method. The power electronics converters presented are used alone but the method can be easily extended to cascaded devices allowing the simulation of complex power electronic structures such as, for example, active filters with non-linear loads.
Lobectomy is removal of an individual lobe by ligating its contributing pulmonary artery, pulmonary vein, and lobar bronchi. Indications for pulmonary lobectomy include malignancy, to diagnose pathology of a nodule or mass, traumatic injury, broncho-pleural fistula, and bronchiectasis.
Detailed surgical techniques are beyond the realm of this chapter and have been explained in other chapters. Broadly speaking, it is open or minimally invasive lung resection. Minimally invasive techniques have shown benefit when compared with open thoracotomy. Several systematic reviews have reported faster recovery and shorter hospital stay with minimally invasive technique [1, 2, 3, 4, 5, 6, 7]. Older patients are independent sooner with minimally invasive procedures compared with larger chest incisions despite the extent of surgery being similar internally.
The post-operative mortality rates after a major thoracic surgical procedure can range from 2 to 5%. The cardiopulmonary morbidity can range between 20 to 40% and this can result in prolonged hospital stay and increased cost. There are several patients related and procedure related risk factors which can indicate a high risk of postoperative complications.
The patient related risk factors include:
ASA (American Society of Anaesthesiologists) physical status ≥ 3
S-MPM (Surgical mortality probability model) ≥ 6 points
RCRI (Revised cardiac risk index) > 2 points
ThRCRI (Thoracic RCRI) >1.5 points
ARISCAT (Assess Respiratory Risk in Surgical patients in Catalonia risk index) > 45 points
Preoperative FEV1< 60%
Predictive-DLCO < 30%
The Procedure-related risk factors include:
High risk procedure
Major intraoperative complications like refractory hypotension, myocardial ischemia, cardiac arrhythmia, major haemorrhage, and bronchial aspiration
Low level of hospital and operative expertise
Emergency operation
It is usually advisable to shift any of the above patients to ICU for post-operative monitoring.
While patient is intubated, regular suctioning is helpful for secretion clearance, avoid lung collapse and development of pneumonia. After extubation, chest physiotherapy, incentive spirometry and ambulation are important to promote secretion clearance.
Usually, patients are extubated in theatre or recovery post operatively. If they continue to be ventilated, aim is to minimize barotrauma by using low tidal volume ventilation and moderate levels of PEEP (less than 10 cm water). Significant air trapping and auto-PEEP is not uncommon in patients with emphysema. Adequate tidal volume and expiratory time and avoiding excess PEEP will help in preventing air trapping. Ventilator should be weaned as soon as possible to prevent nosocomial infection and promote patient participation in early mobilisation and physiotherapy.
In selected patients, high-flow nasal cannula oxygen therapy may be used cautiously to treat hypoxemia after extubation in the early postoperative period [8]. While not routinely used after pulmonary resection, continuous positive airway pressure (CPAP) is reasonable if otherwise indicated (e.g., obstructive sleep apnoea). In small studies, CPAP appears to improve oxygenation without increasing air leakage through the chest drain or the incidence of other postoperative complications [9, 10].
It is important to maintain adequate intravascular volume to maintain adequate cardiac output. Fluid therapy is aimed at maintaining low or low-normal cardiac filling pressures. Restrictive fluid strategy may reduce pulmonary complications and facilitate early extubation. While the fluid regimen should be individualized to optimize cardiac output and oxygen delivery, excessive fluid administration (i.e., >3 L in the 24 hours of the perioperative period) is associated with acute lung injury and delayed recovery after open thoracic surgery [11, 12, 13, 14, 15, 16, 17]. In one study, the risk of acute lung injury increased for each 500 mL increment of perioperative fluid (odds ratio [OR] 1.17, 95% CI 1.00–1.36). [12]
Invasive cardiac monitoring is usually not needed beyond first 24 hours. In our practice, we prefer to give bolus dose of intravenous fluids rather than continuous maintenance fluid.
The combination of general anaesthesia and thoracic epidural analgesia can cause hypotension. Rather than administering additional fluid to support BP in a euvolemic patient, we suggest using an infusion of a low dose of a vasopressor agent typically noradrenaline to maintain adequate Mean Arterial Pressure.
Thoracotomy induces severe postoperative pain which can cause respiratory complications, such as hypoxia, atelectasis, and pulmonary infections. In addition, inadequate pain control can lead to post-thoracotomy pain syndrome, which may continue for many years; therefore excellent analgesia after lung surgery is vital. This will allow deep breathing, coughing and early mobilisation.
It is well established that VATS offers the benefit of major pulmonary resection with decreased early postoperative pain, decreased need for opioid analgesia, decreased hospital stay, and faster recovery and return to preoperative activities [18, 19]. Minimally invasive lung resection confers an improved short-term quality of life and decreased chronic pain as documented in several studies [20, 21, 22, 23].
Guidelines on postoperative analgesia published by the American Society of Regional Analgesia and Pain Medicine and the American Society of Anaesthesiologists’ Committee on Regional Anaesthesia emphasise the importance of multimodal agents which work on different pain pathways and use of systemic and local-regional analgesia to support opioid-sparing strategies and reduce systemic side effects.
Administration routes are multiple including intravenous, subcutaneous, and oral preparations. The most habitual way is the patient-controlled analgesia (PCA) transitioning to oral opioids once patient has resumed oral intake. Common agents for PCA are morphine, fentanyl, and oxycodone. Other common opioids are codeine and tramadol. Basal infusion of opioids, with or without PCA, must be limited in opioid-naive patients because of the increased risk of side effects, including hypotension, respiratory depression, itching, nausea, vomiting, ileus, confusion, and sedation.
With Non-steroidal anti-inflammatory drugs (NSAIDs) the use of opioids is reduced but more risk of kidney injury, gastric bleeding, and effect on platelets aggregation. In our practice, nonsteroidal drugs are usually avoided if concomitant pleurodesis is performed. Paracetamol is an acetanilide derivative which can be given both orally and intravenously. Paracetamol acts by inhibiting substance P action and central prostaglandin synthesis. N-methyl-D-aspartate (NMDA) antagonists Ketamine is another opioid sparing agent, but side effects include hallucinations and restricted mobility with continuous intravenous infusion. Gabapentinoids may help reducing neuropathic pain after thoracic surgery. Literature indicates that preoperative administration of gabapentinoids may also reduce postoperative pain and opioid usage.
Thoracic epidural analgesia (TEA) is considered the gold standard technique in pain management, usually recommended as first line after thoracic surgery. It provides better pain relief than opioid PCA treatment and permits a faster recovery. Local anaesthetics added to opioids in TEA increase analgesia efficacy. Major deterrent to epidural use is its invasiveness. Other side effects could be sympathetic blockade, respiratory depression, and urinary retention.
Thoracic paravertebral block (TPVB) is commonly used, especially with VATS approach. It is often proposed as an alternative to TEA because results in term of pain control are comparable to TEA, with fewer side effects. Pain in the very immediate post-operative period can be covered with a single shot of TPVB but to have a longer analgesic effect, a continuous TPVB analgesia with a catheter placed in the paravertebral space should be considered.
Intercostal nerve block is a very well-known technique, especially to treat pain after thoracotomy. Both the single-shot technique and the continuous infusion are possible with infusion more effective after thoracic surgery. The continuous infusion of local anaesthetic in the intercostal space provides pain relief comparable to TEA, until approximately the 5th postoperative days after open surgery.
Serratus anterior plane block (SAPB) is a thoracic wall nerve block that covers the lateral cutaneous branch of the intercostal nerves from T2 to T9. The SAPB provides more hemodynamic stability compared with TEA after thoracotomy and reinforces PCA analgesia reducing pain and opioid use. In patients undergoing VATS, the loco-regional techniques help in both reducing pain and opioid consumption in the first 24–48 hours after intervention.
Postoperative antibiotic prophylaxis after lobectomy is controversial. Deguchi et al has shown that prophylactic antibiotic administration in both intraoperative and postoperative periods reduced the incidence of pneumonia after pulmonary lobectomy for non-small cell lung cancer [24]. A prospective randomized double-blind trial of flash cefuroxime versus forty-eight- hour cefuroxime in pulmonary surgery has shown the benefit of reducing the rate of deep infections and particularly the rate of empyema [25]. However, a double blind, placebo controlled, randomized trial by Oxman et al has shown not to reduce the number of infectious complications compared with preoperative prophylaxis only [26]. In our institution, 24 hours of antibiotic post operatively is usually prescribed based on local microbiologic susceptibility.
Early introduction of nutrition helps in recovery post operatively. Inadequate calorie and protein intake during critical illness is associated with poor clinical outcomes. Nutritional risk screening should be performed within 24–48 hours of hospital admission to identify patients at high risk of malnutrition. Nutrition Risk in the Critically Ill (NUTRIC score) and Nutritional Risk Screening 2002 (NRS 2002) have been extensively studied as screening tools. Once a patient is identified as at risk, formal nutritional assessment by a trained healthcare professional should be performed. An enteral formula with appropriate macronutrient and micronutrient composition may assist patients in meeting nutritional goals. Conventionally, enteral nutrition is encouraged to help maintain gut structure and function including that of the T-cell associated lymphoid tissues and neutrophil activation [27]. The ASPEN guidelines published recently suggest feeding between 12 and 25 kcal/kg in the first 7–10 days of ICU stay with protein intake 1.2–2 kcal/kg/day [28]. Parenteral nutrition is usually not needed in postoperative patients with pulmonary lobectomy. However, if enteral feed is not tolerated, parenteral nutrition may be considered.
Incidence of acute kidney injury has been reported in 6–10% patients undergoing lung resection surgery with more complicated intra-hospital course. Hence, maintain normovolemia, normal cardiac output, avoid nephrotoxic medications and monitor urine output along with renal function.
These typically incorporate aspects of preoperative, intraoperative, and postoperative care to reduce morbidity. Specific Enhanced Recovery Protocols for thoracic surgery have shown benefits in reduced opioid use, less fluid administration, decreased pulmonary and cardiac morbidity, and reduced hospital length of stay [29, 30, 31].
Following lobectomy, one or more chest tubes are placed in the thoracic cavity. Chest tubes are typically placed through a separate incision when a thoracotomy is performed. When a minimally invasive technique is performed, chest tubes can also be placed directly through the port sites. In a trial that randomly assigned 40 patients to thoracic drainage using the same intercostal space as the thoracotomy incision or traditional chest drainage using a separate incision, the mean lengths of hospital or intensive care unit stay, pain scores, and complications (including infection) were similar between the groups [32].
Postoperative management of chest tubes is directed by postoperative imaging, presence or absence of air leak and the volume and/or character of drainage. Following both open and minimally invasive techniques, typically the chest tube is connected to suction in the immediate postoperative period for at least 12 hours, then disconnect the suction leaving the chest tube to water seal.
The decision to place a chest tube to suction versus water seal alone, if a postoperative pleural leak is present, is controversial. Multiple randomized trials have compared outcomes for patients assigned to chest tubes placed to water seal or to suction following lung resection following a brief period of suction [33, 34, 35, 36, 37, 38]. A meta-analysis that included 7 RCTs found no difference in duration of air leak, incidence of prolonged air leak, duration of chest tubes and duration of hospital stay when chest tubes were placed to suction rather than water seal [39].
Chest tubes must be evaluated multiple times every day to ensure patency of the tubes, and to assess for their on-going requirement. We leave the chest tubes in position as long as there is any air leak, or the draining fluid effluent volume is >300 mL/day.
Pulmonary complications following thoracic surgery are the most common cause of morbidity followed by cardiovascular-related morbidity, and the incidence of these complications increase with increasing age. In general, complications related to minimally invasive thoracic procedures are similar to those of the open surgical approaches. Common complications following lung resection include arrhythmias, postoperative atelectasis, respiratory failure, bleeding, surgical site infection, prolonged postoperative air leak, and bronchopleural fistula.
In a secondary analysis of the American College of Surgeons Oncology Group (ACOSOG) Z0030 trial [40], the incidence of respiratory failure requiring ventilation was 3.7% and Adult Respiratory Distress Syndrome was 0.3%. Pulmonary complications such as atelectasis, bronchospasm and pneumonia can lead to respiratory failure. In a retrospective study of nearly 17,000 patients undergoing lung resection surgery, 3.5% required re-intubation. Risk factors for reintubation included age, male gender, clinically significant comorbidities (or ASA physical status ≥4), tobacco use, and prolonged duration of surgery [41].
Pulmonary oedema can be seen in 1–5% patients after pulmonary lobectomy. It is a noncardiogenic and non-infectious pulmonary oedema caused by increased permeability and diffuse alveolar damage. The treatment of this pulmonary oedema is to “keep the patient dry”, early reintubation or trial of non-invasive ventilation in cases of respiratory failure. In addition, administration of inotropic/vasopressor drugs, while restricting fluid intake as mentioned above.
Supraventricular tachyarrhythmia is more common than ventricular rhythm disturbances after noncardiac thoracic surgery. Atrial fibrillation (AF) is the most common arrhythmia occurring in 10–20% of patients after lobectomy and occurs most commonly in first four days postoperatively. Risk factors for AF after lung cancer surgery are increasing age, increasing extent of operation, male sex, non-black race and stage II or greater tumour [42].
Extensive guidelines are available from the American Association for Thoracic Surgery [43]. There are some prevention strategies which help reduce the postoperative atrial fibrillation. These strategies include correction of magnesium when abnormal and also avoiding beta-blockade withdrawal for those chronically on these medications. It may be reasonable to administer diltiazem to patients with preserved cardiac function who are not on beta blockers preoperatively or to give post-operative amiodarone to reduce incidence of post-operative AF. Simple treatment strategies to control AF includes the optimization of fluid balance, correct electrolytes and treat triggering factors (bleeding, pulmonary embolism, pneumothorax, pericardial processes, airway issues, myocardial ischemia, or infection). For hemodynamically unstable patient with the new onset post-operative AF of less than 48 hours duration, emergency DC cardioversion is indicated. For hemodynamically stable patient, rate control strategy is reasonable. Agents commonly used are beta blockers, non-dihydropyridine calcium channel blockers or digoxin. Rhythm control with antiarrhythmic drugs and/or DC cardioversion can be useful for patients with hemodynamically stable new onset AF who have recurrent or refractory AF, continued symptoms, intolerance to rate control medications, or ventricular rates that cannot be adequately controlled. For rhythm control, amiodarone is the most common drug used. Other agents which can be used are sotalol and flecainide.
Post lobectomy haemorrhage is rare but most common indication for reoperation. In a recent single centre retrospective review [44], out of 1960 lobectomies, haemorrhage occurred in 2.1% cases, leading to reoperation in 1.4% and non-operative management in 0.8% cases. The median time for reoperation was 17 hours.
Persistent postoperative air leak, defined arbitrarily as pulmonary leak of more than seven days, occurs in 10–15% of patients following lobectomy. Persistent air leaks are more common in patients with severe COPD. Management is often conservative with on-going chest tube drainage or home discharge with one way flutter valve. Most air leaks seal within two weeks with conservative care. Postoperatively, patients should be extubated as soon as possible to reduce intrapulmonary pressure. Other treatments including injection of talc, other sclerosing agents and autologous blood may be helpful to close a persisting air leak. In more difficult cases, intrabronchial valves have been proposed to close alveolar pleural fistulas.
Bronchopleural fistula, which is a direct communication of the bronchus and the pleural space, is a major complication of lung resection and occurs in 1–2% of lobectomies. Management requires reoperation for bronchial closure, pleural space drainage, and sterilization.
Injury to the diaphragm, liver, or spleen may occur, particularly during port placement with consequent morbidity.
ICU management of patients with pulmonary lobectomy is required for two main reasons: post-operative setting or acute complications following surgery. Careful pre-operative assessment of patients is mandatory to reduce post-operative morbidity and mortality. The requirement of ICU depends upon the patient and on local specifics. Several cardiac and respiratory complications can happen in ICU following admission after pulmonary lobectomy. Prevention and early recognition, as well as interdisciplinary cooperation are essential to obtain the best patient centred outcome.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. 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With examples from selected protected areas in Southern Africa, this chapter highlights studies on detected climate changes particularly rainfall and temperature, outlines the predicted and observed impacts of climate change and variability on wildlife resources in savannah ecosystems and highlights the adaptation and mitigation strategies and implications for conservation. Literature indicates that Southern Africa is characterised by highly variable, erratic and unpredictable rainfall and increasing temperature coupled with an increasing trend in climate-related extreme events such as frequent droughts, cyclones and heat waves. Drought, in particular, has led to death in several wildlife species. This has implications on long-term survival of the species. Changes in rainfall and temperature patterns influence habitat quality and consequently abundance of distribution of wildlife species. Large herbivores such as elephants and hippopotamus in particular are vulnerable to climate change due to their ecology, whereas other species are less vulnerable. Climate-related extreme events, coupled with other anthropogenic stressors, interact to influence changes in abundance and distribution of wildlife resources. Understanding the influence of these climatic factors on wildlife resources is vital for adaptive management and protection of biodiversity.",book:{id:"5934",slug:"selected-studies-in-biodiversity",title:"Selected Studies in Biodiversity",fullTitle:"Selected Studies in Biodiversity"},signatures:"Olga L. 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Given, the obvious risk of loss of diversity, it is increasingly necessary to take actions concerning preservation, in which safety features are necessary for measuring the variation of diversity in space and time. The aim of this study was to evaluate the structure and diversity in the arboreal component and natural regeneration in an area of Araucaria Forest in Southern Brazil. The vegetation sampling was performed by analyzing 180 subunits of 10 × 10 m, where all the arboreal individuals and natural regeneration were inventoried. Different alpha and beta indexes of diversity were calculated. The Margalef, Shannon, and the Beta indexes were underestimated, possibly influenced by the size of sample unit. Index Menhinick represented the diversity in a very real form, even in small sampling units. The indexes of Simpson and MacIntosh denote low dominance and the equity indexes showed high uniformity in species.",book:{id:"5934",slug:"selected-studies-in-biodiversity",title:"Selected Studies in Biodiversity",fullTitle:"Selected Studies in Biodiversity"},signatures:"Maria Raquel Kanieski, Solon Jonas Longhi and Philipe Ricardo\nCasemiro Soares",authors:[{id:"219216",title:"Dr.",name:"Maria Raquel",middleName:null,surname:"Kanieski",slug:"maria-raquel-kanieski",fullName:"Maria Raquel Kanieski"},{id:"220250",title:"Dr.",name:"Solon Jonas",middleName:null,surname:"Longhi",slug:"solon-jonas-longhi",fullName:"Solon Jonas Longhi"},{id:"220251",title:"Dr.",name:"Philipe Ricardo",middleName:null,surname:"Casemiro Soares",slug:"philipe-ricardo-casemiro-soares",fullName:"Philipe Ricardo Casemiro Soares"}]},{id:"46541",title:"Ecosystem Biodiversity of India",slug:"ecosystem-biodiversity-of-india",totalDownloads:3492,totalCrossrefCites:1,totalDimensionsCites:4,abstract:null,book:{id:"3821",slug:"biodiversity-the-dynamic-balance-of-the-planet",title:"Biodiversity",fullTitle:"Biodiversity - The Dynamic Balance of the Planet"},signatures:"Vivek Khandekar and Anita Srivastava",authors:[{id:"51372",title:"Dr.",name:"Anita",middleName:null,surname:"Srivastava",slug:"anita-srivastava",fullName:"Anita Srivastava"},{id:"170148",title:"Dr.",name:"Vivek",middleName:null,surname:"Khandekar",slug:"vivek-khandekar",fullName:"Vivek Khandekar"}]},{id:"38697",title:"Floral and Avifaunal Diversity of Thol Lake Wildlife (Bird) Sanctuary of Gujarat State, India",slug:"floral-and-avifaunal-diversity-of-thol-lake-wildlife-bird-sanctuary-of-gujarat-state-india",totalDownloads:4012,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"2719",slug:"biodiversity-enrichment-in-a-diverse-world",title:"Biodiversity Enrichment in a Diverse World",fullTitle:"Biodiversity Enrichment in a Diverse World"},signatures:"Jessica P. Karia",authors:[{id:"142623",title:"Dr.",name:"Jessica",middleName:null,surname:"Karia",slug:"jessica-karia",fullName:"Jessica Karia"}]},{id:"38612",title:"Soil Fauna Diversity - Function, Soil Degradation, Biological Indices, Soil Restoration",slug:"soil-fauna-diversity-function-soil-degradation-biological-indices-soil-restoration",totalDownloads:7791,totalCrossrefCites:27,totalDimensionsCites:59,abstract:null,book:{id:"3007",slug:"biodiversity-conservation-and-utilization-in-a-diverse-world",title:"Biodiversity Conservation and Utilization in a Diverse World",fullTitle:"Biodiversity Conservation and Utilization in a Diverse World"},signatures:"Cristina Menta",authors:[{id:"145410",title:"PhD.",name:"Cristina",middleName:null,surname:"Menta",slug:"cristina-menta",fullName:"Cristina Menta"}]}],onlineFirstChaptersFilter:{topicId:"841",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82587",title:"Introductory Chapter: Factors That Affect Biodiversity and Species Richness of Ecosystems - A Review",slug:"introductory-chapter-factors-that-affect-biodiversity-and-species-richness-of-ecosystems-a-review",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.105890",abstract:null,book:{id:"10763",title:"Biodiversity of Ecosystems",coverURL:"https://cdn.intechopen.com/books/images_new/10763.jpg"},signatures:"Levente Hufnagel and Ferenc Mics"},{id:"81863",title:"Exploiting the Attributes of Biocontrol Agent (Neochetina bruchi) as a Potential Ecosystem Engineer’s",slug:"exploiting-the-attributes-of-biocontrol-agent-neochetina-bruchi-as-a-potential-ecosystem-engineer-s",totalDownloads:8,totalDimensionsCites:0,doi:"10.5772/intechopen.104775",abstract:"The biodiversity of lakes is continuously declining and diverse communities are being substituted by monoculture of invasive Eichhornia crassipes, resulting in a slew of environmental cascade effects. The ability of the Neochetina bruchi to self-perpetuate is a desirable aspect of biological control since it decreases the population to a reasonable level, making the approach more sustainable. N. bruchi is often referred to as “ecological engineers” because of the number of services it provides to the environment and enables herbicide application to be substantially reduced. Despite the presence of highly effective weevils against this weed, its effect on water hyacinth in association with the nutrients present in sites, is likely to vary with levels of disturbance caused by natural and anthropogenic factors. Understanding the aspects that determine the performance of these eco-engineers as valuable management tools will help to guide future endeavors. Our objective is to better comprehend their utility and limitations, along with critical knowledge gaps, to further enhance future applications.",book:{id:"10763",title:"Biodiversity of Ecosystems",coverURL:"https://cdn.intechopen.com/books/images_new/10763.jpg"},signatures:"Prerna Gupta and Sadhna Tamot"},{id:"80833",title:"Comparison of the Effectiveness of Different Tags in the Sea Urchin Paracentrotus lividus (Lamarck, 1816)",slug:"comparison-of-the-effectiveness-of-different-tags-in-the-sea-urchin-paracentrotus-lividus-lamarck-18",totalDownloads:61,totalDimensionsCites:0,doi:"10.5772/intechopen.102594",abstract:"The marking of sea urchins was implemented with the main objective of being able to individually identify the urchins in the natural environment once released. In addition, it’s very useful to monitor individuals in studies of growth, movements, development, population dynamics, etc., that develop in the natural environment. Numerous different marking methodologies have been tested for sea urchins, either by physical marking (external and internal labels) or by using chemical marking methods consisting of the use of fluorochromes, which adhere to the calcified structures of the urchin. In this work, 5 different physical marks were used to mark 400 urchins of the Paracentrotus lividus species, which were kept for a month at the ECIMAT facilities in Toralla island. The efficacy of the methods used in each case was analyzed, comparing the survival rate and the tag retention rate of the tagged urchins obtained with each tagging methodology.",book:{id:"10763",title:"Biodiversity of Ecosystems",coverURL:"https://cdn.intechopen.com/books/images_new/10763.jpg"},signatures:"Noelia Tourón, Estefanía Paredes and Damián Costas"},{id:"79769",title:"Elucidation of Some Ecological Traits of Carabids (Coleoptera: Carabidae) Inhabiting Kakuma Campus Grassland, Kanazawa City, Japan",slug:"elucidation-of-some-ecological-traits-of-carabids-coleoptera-carabidae-inhabiting-kakuma-campus-gras",totalDownloads:46,totalDimensionsCites:0,doi:"10.5772/intechopen.101658",abstract:"Although adult feeding habits and food requirements are currently and reasonably well known for many coleopteran species, still some carabid species are with peculiar feeding guilds. Although many studies have shown a relationship between morphology of mandibles and feeding behavior in different taxal group, still many aspects concerning the feeding behavior of carabids are promising. An assemblage of carabid species was collected from Kakuma Campus grassland in Kanazawa City, Japan. These species were represented by five subfamilies and nine tribes where the highest number of tribes (3 tribes) was confined to subfamily Harpalinae. The collected carabid assemblage was subjected to mandibular analysis and being categorized into two main groups; carnivorous and omnivorous species. Homologies among mandibular characteristics and functional adaptations of the mandible were also proposed to explore how the interaction network of carabids can affect their behavior in different habitats.",book:{id:"10763",title:"Biodiversity of Ecosystems",coverURL:"https://cdn.intechopen.com/books/images_new/10763.jpg"},signatures:"Shahenda Abu ElEla Ali Abu ElEla, Wael Mahmoud ElSayed and Nakamura Koji"},{id:"79313",title:"The Diversity of Endophytic Aspergillus",slug:"the-diversity-of-endophytic-aspergillus",totalDownloads:132,totalDimensionsCites:0,doi:"10.5772/intechopen.99717",abstract:"In plants, endophytic fungi and plant are closely related, endophytic fungi can use substances in plants as nutrients to survive. In return, they bring many benefits to the plant, playing an important role in protecting the host plant against the harmful effects of insects, harmful microorganisms or environmental disadvantages. Recently, secondary fungi metabolites, especially endophytic fungi, are gaining interest because they can produce many bioactive metabolites with antibacterial, anticancer and antioxidant properties. Some endophytic fungi are noted as Aspergillus, Penicllium, Fusarium due to the production of many metabolites for biological effects such as antibacterial, antiviral, anticancer, etc. in which Aspergillus species product many compounds have properties antibacterial such as terrequinon A, terrefuranon, Na-acetyl aszonalemin, etc.",book:{id:"10763",title:"Biodiversity of Ecosystems",coverURL:"https://cdn.intechopen.com/books/images_new/10763.jpg"},signatures:"Vo Thi Ngoc My and Nguyen Van Thanh"},{id:"79203",title:"Soil Biodiversity and Root Pathogens in Agroecosystems",slug:"soil-biodiversity-and-root-pathogens-in-agroecosystems",totalDownloads:158,totalDimensionsCites:0,doi:"10.5772/intechopen.99317",abstract:"Soil ecosystem is a living and dynamic environment, habitat of thousands of microbial species, animal organisms and plant roots, integrated all of them in the food webs, and performing vital functions like organic matter decomposition and nutrient cycling; soil is also where plant roots productivity represent the main and first trophic level (producers), the beginning of the soil food web and of thousands of biological interactions. Agroecosystems are modified ecosystems by man in which plant, animal and microorganisms biodiversity has been altered, and sometimes decreased to a minimum number of species. Plant diseases, including root diseases caused by soil-borne plant pathogens are important threats to crop yield and they causes relevant economic losses. Soil-borne plant pathogens and the diseases they produce can cause huge losses and even social and environmental changes, for instance the Irish famine caused by Phytophthora infestans (1845–1853), or the harmful ecological alterations in the jarrah forests of Western Australia affected by Phytophthora cinnamomi in the last 100 years. How can a root pathogen species increase its populations densities at epidemic levels? In wild ecosystems usually we expect the soil biodiversity (microbiome, nematodes, mycorrhiza, protozoa, worms, etc.) through the trophic webs and different interactions between soil species, are going to regulate each other and the pathogens populations, avoiding disease outbreaks. In agroecosystems where plant diseases and epidemics are frequent and destructive, soil-borne plant pathogens has been managed applying different strategies: chemical, cultural, biological agents and others; however so far, there is not enough knowledge about how important is soil biodiversity, mainly microbiome diversity and soil food webs structure and function in the management of root pathogens, in root and plant health, in healthy food production, and maybe more relevant in the conservation of soil as a natural resource and derived from it, the ecosystem services important for life in our planet.",book:{id:"10763",title:"Biodiversity of Ecosystems",coverURL:"https://cdn.intechopen.com/books/images_new/10763.jpg"},signatures:"María del Pilar Rodríguez Guzmán"}],onlineFirstChaptersTotal:12},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:331,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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His research interests and specialties include financial econometrics, financial economics, international economics and finance, housing markets, financial markets, among others.",institutionString:null,institution:{name:"University of Southampton",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"86",title:"Business and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/86.jpg",isOpenForSubmission:!0,annualVolume:11970,editor:{id:"128342",title:"Prof.",name:"Vito",middleName:null,surname:"Bobek",slug:"vito-bobek",fullName:"Vito Bobek",profilePictureURL:"https://mts.intechopen.com/storage/users/128342/images/system/128342.jpg",biography:"Dr. Vito Bobek works as an international management professor at the University of Applied Sciences FH Joanneum, Graz, Austria. 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Dr. Bobek is also a co-founder of the Academy of Regional Management in Slovenia.",institutionString:"Universities of Applied Sciences FH Joanneum, Austria",institution:{name:"Universities of Applied Sciences Joanneum",institutionURL:null,country:{name:"Austria"}}},editorTwo:{id:"293992",title:"Dr.",name:"Tatjana",middleName:null,surname:"Horvat",slug:"tatjana-horvat",fullName:"Tatjana Horvat",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hXb0hQAC/Profile_Picture_1642419002203",biography:"Tatjana Horvat works as a professor for accountant and auditing at the University of Primorska, Slovenia. She is a Certified State Internal Auditor (licensed by Ministry of Finance RS) and Certified Internal Auditor for Business Sector and Certified accountant (licensed by Slovenian Institute of Auditors). At the Ministry of Justice of Slovenia, she is a member of examination boards for court expert candidates and judicial appraisers in the following areas: economy/finance, valuation of companies, banking, and forensic investigation of economic operations/accounting. 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His teaching interests revolve around global economies and markets while his research focuses on topics related to development and growth, global business decisions, and the economics of technical innovation.",institutionString:null,institution:{name:"University of Houston",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},{id:"88",title:"Marketing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/88.jpg",isOpenForSubmission:!0,annualVolume:11972,editor:{id:"203609",title:"Associate Prof.",name:"Hanna",middleName:null,surname:"Gorska-Warsewicz",slug:"hanna-gorska-warsewicz",fullName:"Hanna Gorska-Warsewicz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSD9pQAG/Profile_Picture_2022-06-14T11:58:32.jpeg",biography:"Hanna Górska-Warsewicz, Ph.D. is Associate Professor at Warsaw University of Life Sciences and Head of Department of Food Market and Consumption Research. She specializes in the subject of brands, brand equity, and brand management in production, service, and trade enterprises. She combines this subject with marketing and marketing management in both theoretical and practical aspects. Prof. Hanna Górska-Warsewicz also analyzes brands in the context of trademarks, legal regulations and the protection of intangible. She is an author or co-author of over 200 publications in this field, including 8 books. 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His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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