There are two mast cameras (Mastcam) onboard the Mars rover Curiosity. Both Mastcams are multispectral imagers with nine bands in each. The right Mastcam has three times higher resolution than the left. In this chapter, we apply some recently developed deep neural network models to enhance the left Mastcam images with help from the right Mastcam images. Actual Mastcam images were used to demonstrate the performance of the proposed algorithms.