\r\n\tThe study of populations and plant communities in their different aspects; ecological, structural, functional and dynamic, it is essential to establish a posteriori models of forest and agricultural management.
\r\n\r\n\tFor this, the methodological approaches on the type of sampling are considered essential, since there are differences between the purely ecological and the phytosociological methods, despite the fact that both pursue the same objective.
\r\n\tAlthough the ecological method for the knowledge of the vegetation is widely extended, the phytosociological one is no less so, since in the European Union it has been developed as a consequence of policies on sustainability, through which regulations have been issued, such as the habitats directive.
\r\n\tOn the other hand, research on plant dynamics and knowledge of the landscape in an integral way, have multiplied in the last 30 years, which has favored a deep knowledge of the floristic and phytocenotic wealth, which is fundamental for agricultural management, livestock and forestry.
",isbn:"978-1-83969-386-1",printIsbn:"978-1-83969-385-4",pdfIsbn:"978-1-83969-387-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,hash:"0abf2a59ee63fc1ba4fb64d77c9b1be7",bookSignature:"Dr. Eusebio Cano Carmona, Dr. Ricardo Quinto Canas, Dr. Ana Cano Ortiz and Dr. Carmelo Maria Musarella",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/9662.jpg",keywords:"Climatic Factors, Bioclimate, Thermotype, Flora, Conservation, Phytocenosis, Plant Dynamics, Landscape, Cartography, Vegetation Series, Crops, Reforestation",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 23rd 2020",dateEndSecondStepPublish:"January 25th 2021",dateEndThirdStepPublish:"March 26th 2021",dateEndFourthStepPublish:"June 14th 2021",dateEndFifthStepPublish:"August 13th 2021",remainingDaysToSecondStep:"a month",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Cano Carmona and colleagues have directed 12 doctoral theses and more than 200 publications among articles, books, and book chapters. He has participated in national and international congresses with about 250 papers. He has held a number of different academic positions, including Dean of the Faculty of Experimental Sciences at the University of Jaen, Spain, and founder and director of the International Seminar on Management and Conservation of Biodiversity.",coeditorOneBiosketch:"Ricardo Jorge Quinto Canas is currently an Invited Assistant Professor in the Faculty of Sciences and Technology at the University of Algarve – Portugal, and a member of the Centre of Marine Sciences (CCMAR), University of Algarve. His current research projects focus on Botany, Vegetation Science (Geobotany), Biogeography, Plant Ecology, and Biology Conservation, aiming to support Nature Conservation.",coeditorTwoBiosketch:"Ana Cano Ortiz's fundamental line of research is related to botanical bioindicators. She has worked in Spain, Italy, Portugal, and Central America. It presents more than one hundred works published in various national and international journals, as well as books and book chapters; and has presented a hundred papers to national and international congresses.",coeditorThreeBiosketch:"Carmelo Maria Musarella is a biologist, specialized in Plant Biology. He is a member of the permanent scientific committee of the International Seminar on “Biodiversity Conservation and Management” guested by several European universities. He has participated in several international and national congresses, seminars, and workshops and presented oral communications and posters.",coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"87846",title:"Dr.",name:"Eusebio",middleName:null,surname:"Cano Carmona",slug:"eusebio-cano-carmona",fullName:"Eusebio Cano Carmona",profilePictureURL:"https://mts.intechopen.com/storage/users/87846/images/system/87846.png",biography:"Eusebio Cano Carmona obtained a PhD in Sciences from the\nUniversity of Granada, Spain. He is Professor of Botany at the\nUniversity of Jaén, Spain. His focus is flora and vegetation and he\nhas conducted research in Spain, Italy, Portugal, Palestine, the\nCaribbean islands and Mexico. As a result of these investigations,\nDr. Cano Carmona and colleagues have directed 12 doctoral theses\nand more than 200 publications among articles, books and book\nchapters. He has participated in national and international congresses with about\n250 papers/communications. He has held a number of different academic positions,\nincluding Dean of the Faculty of Experimental Sciences at the University of Jaen,\nSpain and founder and director of the International Seminar on Management and\nConservation of Biodiversity, a position he has held for 13 years. He is also a member of the Spanish, Portuguese and Italian societies of Geobotany.",institutionString:"University of Jaén",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Jaén",institutionURL:null,country:{name:"Spain"}}}],coeditorOne:{id:"216982",title:"Dr.",name:"Ricardo Quinto",middleName:null,surname:"Canas",slug:"ricardo-quinto-canas",fullName:"Ricardo Quinto Canas",profilePictureURL:"https://mts.intechopen.com/storage/users/216982/images/system/216982.JPG",biography:"Ricardo Quinto Canas, Phd in Analysis and Management of Ecosystems, is currently an Invited Assistant Professor in the Faculty\nof Sciences and Technology at the University of Algarve, Portugal, and member of the Centre of Marine Sciences (CCMAR),\nUniversity of Algarve. He is also the Head of Division of Environmental Impact Assessment - Algarve Regional Coordination\nand Development Commission (CCDR - Algarve). His current\nresearch projects focus on Botany, Vegetation Science (Geobotany), Biogeography,\nPlant Ecology and Biology Conservation, aiming to support Nature Conservation.\nDr. Quinto Canas has co-authored many cited journal publication, conference articles and book chapters in above-mentioned topics.",institutionString:"University of Algarve",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:{id:"203697",title:"Dr.",name:"Ana",middleName:null,surname:"Cano Ortiz",slug:"ana-cano-ortiz",fullName:"Ana Cano Ortiz",profilePictureURL:"https://mts.intechopen.com/storage/users/203697/images/system/203697.png",biography:"Ana Cano Ortiz holds a PhD in Botany from the University of\nJaén, Spain. She has worked in private enterprise, in university\nand in secondary education. She is co-director of four doctoral\ntheses. Her research focus is related to botanical bioindicators.\nDr. Ortiz has worked in Spain, Italy, Portugal and Central America. She has published more than 100 works in various national\nand international journals, as well as books and book chapters.\nShe has also presented a great number of papers/communications to national and\ninternational congresses.",institutionString:"University of Jaén",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Jaén",institutionURL:null,country:{name:"Spain"}}},coeditorThree:{id:"276295",title:"Dr.",name:"Carmelo Maria",middleName:null,surname:"Musarella",slug:"carmelo-maria-musarella",fullName:"Carmelo Maria Musarella",profilePictureURL:"https://mts.intechopen.com/storage/users/276295/images/system/276295.jpg",biography:"Carmelo Maria Musarella, PhD (Reggio Calabria, Italy –\n23/01/1975) is a biologist, specializing in plant biology. He\nstudied and worked in several European Universities: Messina,\nCatania, Reggio Calabria, Rome (Italy), Valencia, Jaén, Almeria\n(Spain), and Evora (Portugal). He was the Adjunct Professor\nof Plant Biology at the “Mediterranea” University of Reggio\nCalabria (Italy). His research topics are: floristic, vegetation,\nhabitat, biogeography, taxonomy, ethnobotany, endemisms, alien species, and\nbiodiversity conservation. He has authored many research articles published in\nindexed journals and books. He has been the guest editor for Plant Biosystems and a\nreferee for this same journal and others. He is a member of the permanent scientific\ncommittee of International Seminar on “Biodiversity Conservation and Management”, which includes several European universities. He has participated in several\ninternational and national congresses, seminars, workshops, and presentations of\noral communications and posters.",institutionString:'"Mediterranea" University of Reggio Calabria',position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"1",institution:null},coeditorFour:null,coeditorFive:null,topics:[{id:"5",title:"Agricultural and Biological Sciences",slug:"agricultural-and-biological-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"247865",firstName:"Jasna",lastName:"Bozic",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/247865/images/7225_n.jpg",email:"jasna.b@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6893",title:"Endemic Species",subtitle:null,isOpenForSubmission:!1,hash:"3290be83fff5bc015f5bd3d78ae9c6c7",slug:"endemic-species",bookSignature:"Eusebio Cano Carmona, Carmelo Maria Musarella and Ana Cano Ortiz",coverURL:"https://cdn.intechopen.com/books/images_new/6893.jpg",editedByType:"Edited by",editors:[{id:"87846",title:"Dr.",name:"Eusebio",surname:"Cano Carmona",slug:"eusebio-cano-carmona",fullName:"Eusebio Cano Carmona"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6418",title:"Hyperspectral Imaging in Agriculture, Food and Environment",subtitle:null,isOpenForSubmission:!1,hash:"9005c36534a5dc065577a011aea13d4d",slug:"hyperspectral-imaging-in-agriculture-food-and-environment",bookSignature:"Alejandro Isabel Luna Maldonado, Humberto Rodríguez Fuentes and Juan Antonio Vidales Contreras",coverURL:"https://cdn.intechopen.com/books/images_new/6418.jpg",editedByType:"Edited by",editors:[{id:"105774",title:"Prof.",name:"Alejandro Isabel",surname:"Luna Maldonado",slug:"alejandro-isabel-luna-maldonado",fullName:"Alejandro Isabel Luna Maldonado"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophanides",surname:"Theophile",slug:"theophanides-theophile",fullName:"Theophanides Theophile"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"878",title:"Phytochemicals",subtitle:"A Global Perspective of Their Role in Nutrition and Health",isOpenForSubmission:!1,hash:"ec77671f63975ef2d16192897deb6835",slug:"phytochemicals-a-global-perspective-of-their-role-in-nutrition-and-health",bookSignature:"Venketeshwer Rao",coverURL:"https://cdn.intechopen.com/books/images_new/878.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"29236",title:"Innovative Sustainable Companies Management: The Wide Symbiosis Strategy",doi:"10.5772/26727",slug:"innovative-sustainable-companies-management-the-wide-symbiosis-strategy",body:null,keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/29236.pdf",chapterXML:null,downloadPdfUrl:"/chapter/pdf-download/29236",previewPdfUrl:"/chapter/pdf-preview/29236",totalDownloads:1437,totalViews:83,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,dateSubmitted:"February 10th 2011",dateReviewed:"October 11th 2011",datePrePublished:null,datePublished:"February 24th 2012",dateFinished:null,readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/29236",risUrl:"/chapter/ris/29236",book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment"},signatures:"Francesco Fusco Girard",authors:[{id:"67656",title:"Prof.",name:"Francesco",middleName:null,surname:"Fusco Girard",fullName:"Francesco Fusco Girard",slug:"francesco-fusco-girard",email:"francesco.fuscogirard@gmail.com",position:null,institution:null}],sections:null,chapterReferences:null,footnotes:null,contributors:null,corrections:null},book:{id:"2016",title:"Sustainable Development",subtitle:"Policy and Urban Development - Tourism, Life Science, Management and Environment",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment",slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",publishedDate:"February 24th 2012",bookSignature:"Chaouki Ghenai",coverURL:"https://cdn.intechopen.com/books/images_new/2016.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"14569",title:"Prof.",name:"Chaouki",middleName:null,surname:"Ghenai",slug:"chaouki-ghenai",fullName:"Chaouki Ghenai"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"29220",title:"Sustainable System Modelling for Urban Development Using Distributed Agencies",slug:"sustainable-system-modelling-for-urban-development-using-distributed-agencies",totalDownloads:1762,totalCrossrefCites:0,signatures:"Bogart Yail Marquez, Ivan Espinoza-Hernandez and Jose Sergio Magdaleno-Palencia",authors:[{id:"67272",title:"Dr.",name:"Bogart",middleName:"Yail",surname:"Marquez",fullName:"Bogart Marquez",slug:"bogart-marquez"}]},{id:"29221",title:"European Policy for the Promotion of Inland Waterway Transport – A Case Study of the Danube River",slug:"european-policy-for-the-promotion-of-inland-waterway-transport-a-case-study-of-the-danube-river",totalDownloads:1705,totalCrossrefCites:1,signatures:"Svetlana Dj. Mihic and Aleksandar Andrejevic",authors:[{id:"67632",title:"Dr.",name:"Svetlana",middleName:null,surname:"Mihic",fullName:"Svetlana Mihic",slug:"svetlana-mihic"},{id:"136807",title:"Dr.",name:"Aleksandar",middleName:null,surname:"Andrejevic",fullName:"Aleksandar Andrejevic",slug:"aleksandar-andrejevic"}]},{id:"29222",title:"Sustainable Urban Development Through the Empowering of Local Communities",slug:"sustainable-urban-development-through-the-empowering-of-local-communities",totalDownloads:1443,totalCrossrefCites:0,signatures:"Radu Radoslav, Marius Stelian Găman, Tudor Morar, Ştefana Bădescu and Ana-Maria Branea",authors:[{id:"69700",title:"Prof.",name:"Radu",middleName:null,surname:"Radoslav",fullName:"Radu Radoslav",slug:"radu-radoslav"}]},{id:"29223",title:"Sustainable Urban Design and Walkable Neighborhoods",slug:"sustainable-urban-design-and-walkable-neighborhoods",totalDownloads:2765,totalCrossrefCites:0,signatures:"Theresa Glanz, Yunwoo Nam and Zhenghong Tang",authors:[{id:"69579",title:"Prof.",name:"Zhenghong",middleName:null,surname:"Tang",fullName:"Zhenghong Tang",slug:"zhenghong-tang"}]},{id:"29224",title:"Sustainable Tourism of Destination, Imperative Triangle Among: Competitiveness, Effective Management and Proper Financing",slug:"sustainable-tourism-of-destination-imperative-triangle-among-competitiveness-effective-management-an",totalDownloads:3614,totalCrossrefCites:2,signatures:"Mirela Mazilu",authors:[{id:"72582",title:"Prof.",name:"Mirela",middleName:"Elena",surname:"Mazilu",fullName:"Mirela Mazilu",slug:"mirela-mazilu"}]},{id:"29225",title:"Croatian Tourism Development Model – Anatomy of an Un/Sustainability",slug:"croatian-tourism-development-model-anatomy-of-an-un-sustainability",totalDownloads:1923,totalCrossrefCites:1,signatures:"Lidija Petrić",authors:[{id:"72730",title:"Prof.",name:"Lidija",middleName:null,surname:"Petrić",fullName:"Lidija Petrić",slug:"lidija-petric"}]},{id:"29226",title:"Built Heritage and Sustainable Tourism: Conceptual, Economic and Social Variables",slug:"built-heritage-and-sustainable-tourism-conceptual-economic-and-social-variables",totalDownloads:1969,totalCrossrefCites:1,signatures:"Beatriz Amarilla and Alfredo Conti",authors:[{id:"74977",title:"Prof.",name:"Beatriz",middleName:null,surname:"Amarilla",fullName:"Beatriz Amarilla",slug:"beatriz-amarilla"},{id:"78428",title:"Prof.",name:"Alfredo",middleName:null,surname:"Conti",fullName:"Alfredo Conti",slug:"alfredo-conti"}]},{id:"29227",title:"Sustainability Challenges: Changing Attitudes and a Demand for Better Management of the Tourism Industry in Malaysia",slug:"sustainability-challenges-changing-attitudes-and-a-demand-for-better-management-of-the-tourism-indus",totalDownloads:3294,totalCrossrefCites:1,signatures:"Janie Liew-Tsonis and Sharon Cheuk",authors:[{id:"67670",title:"Dr.",name:"Janie",middleName:null,surname:"Liew-Tsonis",fullName:"Janie Liew-Tsonis",slug:"janie-liew-tsonis"},{id:"131050",title:"Ms.",name:"Sharon",middleName:null,surname:"Cheuk",fullName:"Sharon Cheuk",slug:"sharon-cheuk"}]},{id:"29228",title:"Sustainable Development Global Simulation: Analysis of Quality and Security of Human Life",slug:"sustainable-development-global-simulation-analysis-of-quality-and-security-of-human-life",totalDownloads:1285,totalCrossrefCites:1,signatures:"Michael Zgurovsky",authors:[{id:"67789",title:"Prof.",name:"Michael",middleName:null,surname:"Zgurovsky",fullName:"Michael Zgurovsky",slug:"michael-zgurovsky"}]},{id:"29229",title:"People, Places and History – Towards the Sustainability of Social Life in Traditional Environments",slug:"people-places-and-history-towards-the-sustainability-of-social-life-in-traditional-environments",totalDownloads:1367,totalCrossrefCites:0,signatures:"Oscar Fernández",authors:[{id:"70690",title:"Dr.",name:"Oscar",middleName:null,surname:"Fernandez",fullName:"Oscar Fernandez",slug:"oscar-fernandez"}]},{id:"29230",title:"Raise It, Feed It, Keep It – Building a Sustainable Knowledge Pool Within Your R&D Organization",slug:"raise-it-feed-it-keep-it-building-a-sustainable-knowledge-pool-within-your-r-d-organization",totalDownloads:1464,totalCrossrefCites:1,signatures:"Wiebke Schone, Cornelia Kellermann and Ulrike Busolt",authors:[{id:"71126",title:"Prof.",name:"Ulrike",middleName:null,surname:"Busolt",fullName:"Ulrike Busolt",slug:"ulrike-busolt"},{id:"78254",title:"Mrs.",name:"Wiebke",middleName:null,surname:"Schone",fullName:"Wiebke Schone",slug:"wiebke-schone"}]},{id:"29231",title:"Social Accounting Matrix – Methodological Basis for Sustainable Development Analysis",slug:"social-accounting-matrix-methodological-basis-for-sustainable-development-analysis",totalDownloads:2470,totalCrossrefCites:2,signatures:"Sasho Kjosev",authors:[{id:"77523",title:"Prof.",name:"Sasho",middleName:null,surname:"Kjosev",fullName:"Sasho Kjosev",slug:"sasho-kjosev"}]},{id:"29232",title:"Broadening Sustainable Development in Praxis Through Accountability and Collaboration",slug:"broadening-sustainable-development-in-praxis-through-accountability-and-collaboration",totalDownloads:1395,totalCrossrefCites:0,signatures:"Mago William Maila",authors:[{id:"70437",title:"Prof.",name:"Mago William",middleName:null,surname:"Maila",fullName:"Mago William Maila",slug:"mago-william-maila"}]},{id:"29233",title:"An Approach to Sustainable Development by Applying Control Science",slug:"an-approach-to-sustainable-development-by-applying-control-science",totalDownloads:1495,totalCrossrefCites:1,signatures:"Kazutoshi Fujihira",authors:[{id:"69662",title:"BSc.",name:"Kazutoshi",middleName:null,surname:"Fujihira",fullName:"Kazutoshi Fujihira",slug:"kazutoshi-fujihira"}]},{id:"29234",title:"Embedding Sustainable Development in Organizations Through an Integrated Management Systems Approach",slug:"embedding-sustainable-development-in-organizations-through-an-integrated-management-systems-approach",totalDownloads:2077,totalCrossrefCites:3,signatures:"Miguel Rocha and Cory Searcy",authors:[{id:"67964",title:"Dr.",name:"Miguel",middleName:null,surname:"Rocha",fullName:"Miguel Rocha",slug:"miguel-rocha"},{id:"77546",title:"Dr.",name:"Cory",middleName:null,surname:"Searcy",fullName:"Cory Searcy",slug:"cory-searcy"}]},{id:"29235",title:"Sustainable Development as an Aspect of Improving Economic Performance of a Company",slug:"sustainable-development-as-an-aspect-of-improving-economic-performance-of-a-company",totalDownloads:1424,totalCrossrefCites:0,signatures:"Tereza Kadlecová and Lilia Dvořáková",authors:[{id:"70009",title:"Dr.",name:"Tereza",middleName:null,surname:"Kadlecová",fullName:"Tereza Kadlecová",slug:"tereza-kadlecova"},{id:"76495",title:"Prof.",name:"Lilia",middleName:null,surname:"Dvořáková",fullName:"Lilia Dvořáková",slug:"lilia-dvorakova"}]},{id:"29236",title:"Innovative Sustainable Companies Management: The Wide Symbiosis Strategy",slug:"innovative-sustainable-companies-management-the-wide-symbiosis-strategy",totalDownloads:1437,totalCrossrefCites:0,signatures:"Francesco Fusco Girard",authors:[{id:"67656",title:"Prof.",name:"Francesco",middleName:null,surname:"Fusco Girard",fullName:"Francesco Fusco Girard",slug:"francesco-fusco-girard"}]},{id:"29237",title:"Innovation Ecosystem for Sustainable Development",slug:"innovation-ecosystem-for-sustainable-development",totalDownloads:2325,totalCrossrefCites:3,signatures:"Kayano Fukuda and Chihiro Watanabe",authors:[{id:"67348",title:"Dr.",name:"Kayano",middleName:null,surname:"Fukuda",fullName:"Kayano Fukuda",slug:"kayano-fukuda"},{id:"128853",title:"Prof.",name:"Chihiro",middleName:null,surname:"Watanabe",fullName:"Chihiro Watanabe",slug:"chihiro-watanabe"}]},{id:"29238",title:"Unraveling Stakeholders’ Discourses Regarding Sustainable Development and Biodiversity Conservation in Greece",slug:"unraveling-stakeholders-discourses-regarding-sustainable-development-and-biodiversity-conservation-i",totalDownloads:1441,totalCrossrefCites:0,signatures:"Evangelia Apostolopoulou, Evangelia G. Drakou, and John D. Pantis",authors:[{id:"68362",title:"Dr.",name:"Evangelia",middleName:null,surname:"Apostolopoulou",fullName:"Evangelia Apostolopoulou",slug:"evangelia-apostolopoulou"},{id:"78446",title:"Dr.",name:"Evangelia",middleName:null,surname:"Drakou",fullName:"Evangelia Drakou",slug:"evangelia-drakou"},{id:"78448",title:"Prof.",name:"John",middleName:null,surname:"Pantis",fullName:"John Pantis",slug:"john-pantis"}]},{id:"29239",title:"The Environment as a Factor of Spatial Injustice: A New Challenge for the Sustainable Development of European Regions?",slug:"the-environment-as-a-factor-of-spatial-injustice-a-new-challenge-for-the-sustainable-development-of-",totalDownloads:2311,totalCrossrefCites:3,signatures:"Guillaume Faburel",authors:[{id:"68153",title:"Prof.",name:"Guillaume",middleName:null,surname:"Faburel",fullName:"Guillaume Faburel",slug:"guillaume-faburel"}]}]},relatedBooks:[{type:"book",id:"896",title:"Sustainable Development",subtitle:"Energy, Engineering and Technologies - Manufacturing and Environment",isOpenForSubmission:!1,hash:"6918d8cf18ee74d746d53009e3c36249",slug:"sustainable-development-energy-engineering-and-technologies-manufacturing-and-environment",bookSignature:"Chaouki Ghenai",coverURL:"https://cdn.intechopen.com/books/images_new/896.jpg",editedByType:"Edited by",editors:[{id:"14569",title:"Prof.",name:"Chaouki",surname:"Ghenai",slug:"chaouki-ghenai",fullName:"Chaouki Ghenai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"29929",title:"Albedo Effect and Energy Efficiency of Cities",slug:"albedo-effect-and-energy-efficiency-of-cities",signatures:"Aniceto Zaragoza Ramírez and César Bartolomé Muñoz",authors:[{id:"78278",title:"Dr.",name:"Aniceto",middleName:null,surname:"Zaragoza",fullName:"Aniceto Zaragoza",slug:"aniceto-zaragoza"}]},{id:"29930",title:"Life Cycle Analysis of Wind Turbine",slug:"life-cycle-analysis-of-wind-turbine",signatures:"Chaouki Ghenai",authors:[{id:"14569",title:"Prof.",name:"Chaouki",middleName:null,surname:"Ghenai",fullName:"Chaouki Ghenai",slug:"chaouki-ghenai"}]},{id:"29931",title:"Sustainability Assessment of Technologies – An Integrative Approach",slug:"sustainability-assessment-of-technologies-an-integrative-approach",signatures:"Armin Grunwald",authors:[{id:"67340",title:"Prof.",name:"Armin",middleName:null,surname:"Grunwald",fullName:"Armin Grunwald",slug:"armin-grunwald"}]},{id:"29932",title:"Sustainable Engineering and Eco Design",slug:"sustainable-engineering-and-eco-design",signatures:"Chaouki Ghenai",authors:[{id:"14569",title:"Prof.",name:"Chaouki",middleName:null,surname:"Ghenai",fullName:"Chaouki Ghenai",slug:"chaouki-ghenai"}]},{id:"29933",title:"Assessing Long Term Sustainability of Global Supply of Natural Resources and Materials",slug:"assessing-long-term-sustainability-of-global-supply-of-natural-resources-and-materials",signatures:"K.V. Ragnarsdóttir, H.U. Sverdrup and D. Koca",authors:[{id:"72802",title:"Prof.",name:"Kristin",middleName:"Vala",surname:"Ragnarsdóttir",fullName:"Kristin Ragnarsdóttir",slug:"kristin-ragnarsdottir"}]},{id:"29934",title:"The Kaolin Residue and Its Use for Production of Mullite Bodies",slug:"the-kaolin-residue-and-its-use-for-production-of-mullite-bodies",signatures:"M.I. Brasileiro, A.W.B. Rodrigues, R.R. Menezes, G.A. Neves and L.N.L. Santana",authors:[{id:"30176",title:"Dr.",name:"Maria",middleName:"Isabel",surname:"Brasileiro",fullName:"Maria Brasileiro",slug:"maria-brasileiro"},{id:"43588",title:"Dr.",name:"André",middleName:null,surname:"Rodrigues",fullName:"André Rodrigues",slug:"andre-rodrigues"},{id:"43589",title:"Dr.",name:"Romualdo",middleName:null,surname:"Menezes",fullName:"Romualdo Menezes",slug:"romualdo-menezes"},{id:"43590",title:"Dr.",name:"Gelmires",middleName:null,surname:"Neves",fullName:"Gelmires Neves",slug:"gelmires-neves"},{id:"43591",title:"Dr.",name:"Lisiane",middleName:null,surname:"Santana",fullName:"Lisiane Santana",slug:"lisiane-santana"}]},{id:"29935",title:"Integrated Water Resources Management - Key to Sustainable Development and Management of Water Resources: Case of Malawi",slug:"integrated-water-resources-management-key-to-sustainable-development-and-management-of-water-resourc",signatures:"V. Chipofya, S. Kainja and S. Bota",authors:[{id:"79000",title:"Prof.",name:"Victor",middleName:null,surname:"Chipofya",fullName:"Victor Chipofya",slug:"victor-chipofya"}]},{id:"29936",title:"Conjunctive Use of Surface Water and Groundwater for Sustainable Water Management",slug:"conjunctive-use-of-surface-water-and-groundwater-for-sustainable-water-management",signatures:"H. Ramesh and A. Mahesha",authors:[{id:"78133",title:"Dr.",name:"Mahesha",middleName:null,surname:"Amai",fullName:"Mahesha Amai",slug:"mahesha-amai"},{id:"136977",title:"Dr.",name:"H.",middleName:null,surname:"Ramesh",fullName:"H. Ramesh",slug:"h.-ramesh"}]},{id:"29937",title:"Indicators of Traditional Ecological Knowledge and Use of Plant Diversity for Sustainable Development",slug:"indicators-of-traditional-ecological-knowledge-and-use-of-plant-diversity-for-sustainable-developmen",signatures:"Edmundo García-Moya, Columba Monroy-Ortiz, Angélica Romero-Manzanares and Rafael Monroy",authors:[{id:"78475",title:"Dr.",name:"Edmundo",middleName:null,surname:"García-Moya",fullName:"Edmundo García-Moya",slug:"edmundo-garcia-moya"},{id:"78491",title:"Dr.",name:"Angélica",middleName:null,surname:"Romero-Manzanares",fullName:"Angélica Romero-Manzanares",slug:"angelica-romero-manzanares"},{id:"78493",title:"Dr.",name:"Columba",middleName:null,surname:"Monroy-Ortiz",fullName:"Columba Monroy-Ortiz",slug:"columba-monroy-ortiz"},{id:"132008",title:"Dr.",name:"Rafael",middleName:null,surname:"Monroy",fullName:"Rafael Monroy",slug:"rafael-monroy"}]},{id:"29938",title:"An Economy-Environment Integrate Statistic System",slug:"an-economy-environment-integrate-statistic-system",signatures:"Giani Gradinaru",authors:[{id:"67489",title:"Dr.",name:"Giani",middleName:null,surname:"Gradinaru",fullName:"Giani Gradinaru",slug:"giani-gradinaru"}]},{id:"29939",title:"Sustainable Performance and Environmental Health in Brazil: How to Understand and Measure!",slug:"sustainable-performance-and-environmental-health-in-brazil-how-to-understand-and-measure-",signatures:"Márcio Ricardo Costa dos Santos",authors:[{id:"66956",title:"Dr.",name:"Marcio Ricardo",middleName:"Costa Dos",surname:"Santos",fullName:"Marcio Ricardo Santos",slug:"marcio-ricardo-santos"}]}]}]},onlineFirst:{chapter:{type:"chapter",id:"64138",title:"Melatonin and Its Indisputable Effects on the Health State",doi:"10.5772/intechopen.79817",slug:"melatonin-and-its-indisputable-effects-on-the-health-state",body:'\nMelatonin is a hormone (N-acetyl-5 methoxytryptamine) produced especially at night in the pineal gland which helps in the maintenance of the body’s hormone balance and regulation, in immune system integrity, and in circadian rhythm (daily metabolic balance). This gland functions as a biological clock and time keeper of the brain by secreting melatonin and many other neuropeptides at night, helps to govern the sleep-wake cycle and, in animals, seasonal rhythms of migration, mating, and hibernation. Secretion of melatonin is stimulated by the dark and inhibited by light. Melatonin levels start to be released at sunsets, where neural signals are triggered which stimulate the pineal gland to begin releasing the hormone.
\nMelatonin is synthesized from the amino acid tryptophan. Tryptophan (l-tryptophan) is an essential amino acid formed from proteins during digestion by the action of proteolytic enzymes. Tryptophan is converted to serotonin, a brain chemical involved with mood during the day and the latter finally converted to the indole melatonin (Figures 1 and 2). Melatonin occurs naturally in some foods but in fairly small amounts. Of all the plant-based foods, oats, sweet corn and rice are the richest source in melatonin, containing between 1000 and 1800 picograms while ginger, tomatoes, bananas and barley levels amount to 500 picograms per gram. In the human population, melatonin levels are highest in children and middle-aged adults and usually about 5–25 micrograms of melatonin are secreted each night. This amount tends to decline with age, a possible link with an age-related rise in difficulty sleeping and in the production of free radicals [1]. Synthetic melatonin and melatonin derived from bovine pineal glands are available as dietary supplements over-the-counter.
\nChemical structure of Tryptophan (A) and Melatonin (B).
The biosynthesis and metabolism process of melatonin. www.impactjournals.com/oncotarget.
Melatonin, stimulated by darkness and inhibited by light, is involved in synchronizing the body’s hormone secretions and in regulating their levels, setting the brain’s internal biological clock and hence controlling circadian rhythms (daily biorhythms) or sleep-wake. Melatonin regulates many neuroendocrine functions and can inhibit secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the anterior pituitary gland. When the timing or intensity of melatonin peak is disrupted (as in aging, stress, jet-lag, or artificial jet-lag syndromes), the biological clock is upset and many physiological and mental functions are adversely affected including the ability to think, remember, and make sound decisions can be profoundly hampered. Melatonin is also controls the timing and release of female reproductive hormones and hence helps determine when menstruation begins and ends (menopause), and the frequency and duration of menstrual cycles [1].
\nIn addition to its hormone actions, melatonin also has strong antioxidant properties and may scavenge and eliminate cell-damaging free radicals. The latter are chemical constituents that have an unpaired electron and cause lipid peroxidation, DNA damage and protein oxidation. Besides, it inhibits nitric oxide synthetase enzyme leading to reduction in the formation of peroxynitrite in tissues of brain. Melatonin stimulates the activities of antioxidant enzymes; glutathione peroxidase, superoxide dismutase and catalase. Melatonin is twice as effective at protecting cell membranes from lipid peroxidation as vitamin E and is five times more effective than glutathione for neutralizing hydroxyl radicals. As an antioxidant, it possibly helps to control or delay the development of heart disease, cancer and other conditions and may be effective in destroying malignant cells when combined with certain anticancer drugs. Since glutathione concentrations are not very high in the brain, both melatonin and adenosine may be particularly important in protecting brain cells [1].
\nTwo decades ago, melatonin was found to be a free radical scavenger [2]. However, abundant data ascertaining its ability to reduce oxidative stress have rapidly accumulated [3, 4]. The efficacy of melatonin in functioning in this subject is related to its direct free radical scavenging actions. Owing to its chemical formula, melatonin can interact with various forms of free radicals such as H2O2, •OH, singlet oxygen (1O2), superoxide anion (•O2−), peroxynitrite anion (ONOO−) and peroxyl radical (LOO•) [4]. The main photoproduct metabolites of melatonin degradation are potent antioxidants such as N1-acetyl-5-methoxykynuramine (AMK) or N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) [4]. Moreover, investigations on free radicals produced as a result of UV exposure, showed that by using cell-free melatonin-containing systems exposed to UV radiation (UVB: 60%, UVA: 30%) four metabolites were identified by HPLC and LC–MS: 2-OH-melatonin, 4-OH-melatonin, 6-OH-melatonin and AFMK [5]. Since these metabolites are potent antioxidants, this may suggest that, unlike other classic antioxidants, they do not induce prooxidant reactions. In addition, melatonin acts as a potent antioxidant through enhancing activity of antioxidant enzymes [6]. It should be noted that not only enzyme activity, but also gene transcription of antioxidant enzymes such as manganese superoxide dismutase (Mn-SOD), copper-zinc superoxide dismutase (Cu/Zn-SOD), glutathione peroxidase (GPx) and gamma-glutamyl cysteine synthetase (γ-GCS) were maintained by melatonin n brain of rat [4]. This continuing enhancement proposed a possible role of activation of melatonin receptors to modulate antioxidant enzymes regulation following stress signals [7]. Actually, there are some suggestions that melatonin-modified antioxidant enzymes expression following signal pathways of membrane, cytosolic and nuclear receptors [8].
\nIt should be mentioned that synthesis of melatonin is not only confined to the pineal gland, but also extends to various other organs including the skin [4]. After exposure to UV, melatonin is metabolized in the skin and in turn causes production of antioxidant melatonin metabolites in human keratinocytes. This antioxidant cascade can be suggested for the skin, the same as in several described melatonin-related antioxidant cascades in chemical or other tissue homogenate systems [9]. This cascade has been defined as the melatoninergic antioxidative system (MAS) of the skin (Figure 2) forming an important barrier organ and protecting it against UV-induced oxidative stress-mediated damaging events on the nuclear, subcellular, protein and cell morphology level [5]. Melatonin forms a defense mechanism against the multifaceted threats of environmental stress, especially UV, to which the skin is life-long exposed. Owing to its chemical structure, melatonin as well as its metabolites are strongly lipophilic, which renders them easily diffusible in every skin and cell compartment, therefore penetrating beyond the epidermis, namely to the dermis and the hair follicle [10]. When the skin is exposed to UV irradiation, the reactive hydroxyl radical is generated in the skin and reacts directly with melatonin [11]. The scavenging effect of melatonin to hydroxyl radicals causes decrease in the lipid peroxides, oxidation of protein and damage of mitochondrial DNA. Thus, the cascade of melatoninergic antioxidative is significant in decreasing the free radicals emerging from radiation of UV and subsequently performs, a very hopeful strategy to keep the skin versus stressor factor of environmental condition as well as causative agent for aging of skin and promotion of tumor.
\nAnother functional importance of melatonin is its potency to enhance, augment or neutralize the negative effects that stress, drugs and infections have on the body’s immune system. The decrease in melatonin secretion by age is so reliable that blood melatonin levels have been proposed as a measurement of biological age.
\nMelatonin is critical for the regulation of circadian and seasonal changes in various aspects of physiology and neuroendocrine functions [12]. The reduction in life span was detected in rats as a result of a pinealectomy [12], whereas prolongation in the life span occurs upon transfer of pineal gland grafting from young mice into thymus of old mice or into pinealectomized old mice which reveals the ability of melatonin to extend life span [12]. Analysis of available data on the effect of melatonin on longevity supports its geroprotective effect. We believe that melatonin biosafety is important for the study of it’s the long-term effects at different doses and in different strains and species (e.g., in rats). In adequately designed work (50 rats in each group), small doses of melatonin were supplemented at the night (2.5–3 mg/kg), slow the starting of age-associated disorders in function of estrous and elevated the animals survival. There are multiple evident on the melatonin suppressive effect on the growth of impulsive mammary carcinogenesis and that initiated in mice and rats as a results of chemicals and radiation [13, 14, 15], carcinogenesis induced in colon of rats by 1,2-dimethyl hydrazine [16], while, carcinogenesis induced in uterine cervix and vagina of mice by DMBA [16] and liver cancer induced in rats by N-nitrosodiethylamine [17]. In these cases, it was observed that melatonin exerted a positive effect in the treatment of advanced cancer patients [18]. Melatonin has a dual effect: it is potent geroprotector, suppressor of tumor growth in vivo and in vitro. There are no discrepancies between results of the carcinogenic and anticarcinogenic potential of melatonin since previous reports showed that other antioxidants, such as α-tocopherol has geroprotector and tumorigenic effects and could be powerful anticarcinogens as well. The data of melatonin supplementation to perimenopausal women are hopeful [19]. Simultaneously, there are actual results on the unfavorable impacts of melatonin [12] such as melatonin may produce infertility, damage of retina and hypothermia, it stimulates high blood pressure, diabetes, and cancer by suppressing sex drive in males. It was remark that melatonin may be harmful for people with cardiovascular risk factors and it should not be obtain by individuals who have immune-system or mental disorders, or by people administered steroids.
\nBecause of its properties as wide antioxidant and scavenger of free radical, melatonin may act as a preventative factor against damage induced by UV in the skin [5]. Clinically melatonin is worthy to protect damage of sun when it is taken before irradiation of UV [20]. These effects of melatonin as a protective agent versus damage induced by UV have in vitro studies powerful support [20, 21]. Melatonin counteracting the formation of polyamine levels so it enhances cell viability in UV-irradiated fibroblasts, and malondialdehyde accumulation while inhibited apoptosis cells [21].
\nRegarding to Ryoo et al. [22] study in fibroblasts exposed to UV, only 56% of the cells survived (140 mJ/cm2), while the survival rate of cells reached to 92.50% when preincubated with 1 nM melatonin which was paralleled with marked decrease in malondialdehyde and death of cells. Other experimental comparative study using fibroblasts treated by UV declared identical correlation in viability of cells using 100 nM melatonin [21]. Additionally, melatonin is considered as a powerful anti-apoptotic compound that inhibited caspase 9 and caspase 3 by suppresses mitochondria-dependent (intrinsic) apoptosis however, it does not inhibit receptor-dependent (extrinsic) pathway of apoptosis mediated by caspase 8 “[23]. UV irradiation is considered an immediate agent acted directly on skin, the oxidative stress resulting in all known successive, destruction events in the skin can distinctly, only be antagonized by antioxidants, melatonin which is already found at the target sites and at the same time of exposure to UV ([23]. Besides, there is clear evidence that the preventive actions of melatonin against photobiological distraction are ameliorated by the powerful antioxidative characteristic of this compound. Photodamage, is tightly connected with UV-induced generation of ROS and it was shown that melatonin is a markedly powerful free radicals scavenger compared with vitamin C or Trolox, a vitamin E analog [21].
\nTumor growth is showed to be inhibited by melatonin. Melatonin may be of a great value in patients with untreatable metastatic cancer, especially in ameliorating their life quality. Several experiments showed that the levels of melatonin may be connected with risk of breast cancer. Some chemotherapy drugs used to treat breast cancer may be enhanced also by melatonin. Supplementation of melatonin reduces luteinizing hormone concentrations leading to inhibition of ovulation in humans. Further, melatonin administration may aid menopausal women by eliciting and sustaining sleep. Levels of melatonin may have a role in the anorexia symptoms. It was found that melatonin was used in seasonal affective disorder (SAD), due to the disorder is considered to be produced by melatonin release at an inadequate time [1].
\nMelatonin immunopharmacological activity has been indicated in different models. Melatonin treatment elevates antibodies production of sheep erythrocytes and immune response to primary immunization with T-dependent antigens [24]. Melatonin is involved in complicated relationships between the endocrine and nervous systems [25]. There are membrane receptors of melatonin on helper (Th). Melatonin receptors activation results to an elevate the production of Th1 cytokines, such as γ-interferon, interleukin-1, and opioid cytokines (interleukin-4 and dinorphine) [25]. At physiological concentrations of melatonin, it induces release of interleukins-1, -6 and -12 in monocytes of human. These mediators can protect stress-stimulated immunodepression maintaining mice from virus- and bacteria caused lethal diseases [25]. It is useful noticing that γ-interferon and colony-inducing factors (CSFs) can stimulate melatonin release in the pineal gland [25].
\nIt is well accepted that melatonin is considered not only a hormone, but also protector for cells [26], implicated in modulation of immune system, processes of antioxidant and hematopoiesis [27]. Moreover, melatonin has a powerful oncostatic characters, through receptor-dependent and -independent mechanisms [28]. The melatonin receptors MT1 (encoded by MTNR1A) and MT2 (encoded by MTNR1B) are associated with the G-protein-coupled receptor (GPCR) group [26], and are mainly responsible for mediating melatonin downstream effects [29]. The antiproliferative effects melatonin may be due to melatonin–stimulated suppression in the uptake of linoleic acid [26]. Melatonin also demonstrated the probability to be used as adjuvant in therapies of cancer, through augmentation the effects of therapeutic drugs and decreased chemotherapies or radiation side effects [26].
\nSome studies recommended an inverse association between circadian melatonin level and breast cancer incidence. In addition, it was demonstrated high melatonin level up to ≤39.5 pg/mL in female showed high risk for breast cancer than females had high melatonin level > 39.5 pg/mL in a case–control study. Besides, in another five prospective case control, an inverse relationship was demonstrated between risk of breast cancer and the highest levels of aMT6s in urine [30, 31]. In controversy, in case–control study declared that high aMT6s level in urine level was markedly linked with a low breast cancer risk [26]. However, it was demonstrated that, no confirmation was detected between level of melatonin and its association with risk of breast cancer in four case–control studies. Regardless of menopausal status, there is no statistically significant differences was detected in urinary aMT6s level between British women with breast cancer and healthy one in a prospective nested case–control [26]. In postmenopausal women, there was no suggestion that high melatonin levels in urine were inversely associated with risk of breast cancer [32]. In the study of Brown et al. [33], did not document an overall correlation between melatonin levels in urine and the onset risk of breast cancer [33]. Simultaneously, no markedly relation was detected between level of aMT6s and risk of breast cancer (either totally or by status of menopausal) [34].
\nIn other types of cancer, it was found that, the men with low level of aMT6s in the urine below the median first morning connected with a four time increase in risk of in comparison with those with levels above the median. In addition, a case–control study showed that patients with high melatonin-sulfate levels or a high melatonin-sulfate/cortisol ratio were less likely to have prostate cancer or advanced stage prostate. It was found that the serum melatonin levels in women with ovarian cancer were significantly lower compared with control subjects (p < 0.05), demonstrating that decline in circulating melatonin level might contribute to the pathogenesis of ovarian cancer in a retrospective study [35].
\nIt is worth mentioning that, the assessment melatonin levels are not equals, since concentrations of melatonin were determined in various sample as urine, plasma or serum. Also, the concentration of melatonin in human modifies with circadian rhythm; however, it has not been demonstrated which the best time for the sample collection could demonstrate the effects of melatonin. These variations might incorporate in the discrepancy of researches.
\nResearch relating melatonin’s effects on breast cancer is the serious, may be due to that melatonin has reported to attenuate various endocrine physiological biomarkers. Novel works showed that melatonin exhibited antiproliferative action against in vitro cell line of breast cancer [26], and suppressed mammary tumors development in rats [26]. Several melatonin mechanisms as anticancer were identified as it is apoptosis inducer [36], antiestrogenic effect through signaling pathway of ERα and decreased activity of aromatase enzyme [36], attenuation of receptors of melatonin [26], suppression on invasion [37] and angiogenesis [38].
\nProstate cancer is the second most cancer type recorded and the fifth leading cause of cancer mortality in men [26]. It was found that melatonin at pharmacological concentrations could inhibit cell growth of both androgen-dependent and androgen-independent prostate cancer [26], through a range of mechanisms.
\nOne of the leading causes of death among women with genital tract disorders is ovarian cancer [39]. Even though various surgical techniques and chemotherapies have been useful for treatment of ovarian carcinoma, the prognosis remains lacking [40]. In recent years, a few studies have reported the anticancer effect of melatonin on cancer of ovary.
\nCervical cancer is considered the principle leading reason of female tumor worldwide, [41]. The melatonin effect on cervical cancer has been detected in insufficient works.
\nVisceral obesity is a risk factor of endometrial cancer, as it is associated with chronic inflammatory process [42]. Ciortea et al. [42] reported that the combinational treatment of melatonin and estrogen in ovariectomized rats was linked with lower body weight, less intra-retroperitoneal fat, reduction in endometrial proliferation, and less appearance of cellular atypia compared with estrogen replacement treatment. These results show that melatonin supplementation could be used in the prophylaxis of endometrial cancer in menopause women [42].
\nOral cancer is a common type of human head and neck cancers, and the majority of the cases involve oral squamous cell carcinoma [26]. In several in vitro studies, melatonin has shown remarkable effect on oral cancer.
\nIt was reported that melatonin presented effect on oral cancer cell lines as an anti-metastatic action (HSC-3 and OECM-1), through modulation of expression and activity of MMP-9, which was occurred by decreasing acetylation of histone [26]. Also, melatonin could minimize SCC9 and SCC25 cell lines viabilities (both tongue carcinoma), and exhibit suppressive effect on the pro-metastatic ROCK- 1gene expression and HIF-1α pro-angiogenic genes as well as VEGF in SCC9 cell line [43]. Overall, inhibitory effect of melatonin was demonstrated on some oral cancer cells, and its mechanisms of action mainly involved inhibitory effect on metastasis and its related angiogenesis.
\nCancer of liver is considered the common reason of death globally, and hepatocellular carcinoma (HCC) is contributed to the most common type of cancer (70–80%), occurrence in developing countries [44]. Treatment with surgery still remains the most pronounced way for HCC patients, however it is only occurs in a few cases, thus it is necessary to find efficient chemotherapeutic drug [45]. Hence, several studies pointed out to the effects of melatonin on hepatocellular carcinoma. Melatonin modulates the changes produced by N-nitrosodiethylamine-initiated cancer of liver and ameliorates biomarkers of liver enzymes (ALT, AST), levels of antioxidant, as well as the disturbance in circadian clock in mice [46, 47].
\nSO, melatonin exerts its anti-liver cancer effects mainly due to its anti- pro-apoptotic activity (via COX-2/PI3K/AKT pathway attenuation, modulates the ratio of Bcl-2/Bax, as well as it activates ER stress), anti-angiogenesis and anti-invasive effects.
\nRenal cancer is considered the third high cancer accounts for 3% with predominance of a male (3 male/1 female) [26].
\nLung cancer is a principal cause of cancer-related death. For instance, lung cancer is the second most frequent type of cancer in males with approximately 17,330 new cases identified in 2016 in Brazil [26]. Non-small-cell lung cancer (NSCLC) is a main form of cancer of lung [26], and the literatures have suggested that the disturbance of rhythm of melatonin could elevate the incidence of NSCLC [26]. In different researches, melatonin due to mainly because melatonin showed to enhance the effects of it enhances radiotherapy and chemotherapeutic drugs.
\nGastric cancer causes a mortality rate ranking second among malignant tumors worldwide one of the most frequent forms of cancer worldwide [26]. It was recorded that there were 951,600 new cases and 723,100 deaths from gastric cancer in 2012 worldwide [26]. Melatonin has been reported to inhibit gastric cancer through various mechanisms in numerous studies.
\nPancreatic cancer is a highly fatal disease with a relatively low 5-year survival rate [48]. It responds poorly to radiotherapy and chemotherapy because the tumor cells are challenging to apoptosis [49].
\nColorectal cancer is one of the major causes responsible for cancer death worldwide [26], and in several studies, melatonin recorded anticancer potency for various colorectal cancers. Overall, melatonin could be a new tempting therapeutic strategy for colorectal cancer, since it could regulate carcinogenesis, development, and progression of colorectal cancer. The underlying mechanisms involve multiple signaling pathways, including regulation of Ca MKII, ET-1, Nrf2 signaling pathways, and induction of aberrant crypt foci (ACF).
\nThe presenting results on the melatonin genomic effect is rather few. In a study of cytogenecity, it was found that a decrease in the gene activity of ribosomes as a result of a pinealectomy in rats [12]. Menendez-Pelaez et al. [50] declared that melatonin treatment reduces mRNA level in the synthesis porphyrin, and 5- aminolevulinate synthase, in the Syrian hamsters Harderian glands. Melatonin declines mRNA levels of histone H4 and stopped age-attributed mRNA Bcl-2 reduction, in mice thymocytes [12]. Also, melatonin elevated some antioxidant enzymes mRNA (Mn-SOD, Cu,Zn-SOD) in Syrian hamsters Harderian gland [12]. Supplementation of melatonin produced significant enhancement in relative levels of mRNA for Mn-SOD, Cu,Zn-SOD and glutathione peroxidase in cerebral cortexes of rat [12]. Melatonin (1 nM) markedly modulates the mRNA of gonadotropin-releasing hormone. It was observed that melatonin regulate transforming growth factor-α gene expression level, macrophage-colony stimulating factor (M-CSF), tumor necrosis factor-α (TNFα) the stem cell factor in PEC, and interleukin-1β, M-CSF, TNFα, interferon-γ, and the stem cell factor in splenocytes [12]. These results are appropriate with results that the SCN is the main site for the exogenous melatonin effect on the amplitude rhythm of the endogenous melatonin [51]. Medication with melatonin suppressed the development of mammary tumor and regulated HER-2/neu onco gene in transgenic HER-2/neu mice [52].
\nMarked melatonin effect was noticed on some oncogenesis- associated genes expression [12]. Further, myeloblastosis oncogene-like 1 (Mybl1) expression was adjusted by melatonin. On the other hand, melatonin showed a great effect on a large number of genes attributed to exchange of calcium, as cullins, Kcnn4 and Dcamkl1, calmodulin, calbindin, Kcnn2 and Kcnn4. Meanwhile, cullin-1 expression in the heart of mouse is down regulated, that of cullin-5 is significantly upregulated, and cullins-2 and -3 expression are significantly not deformed. Six members of cullin family are included, and are implicated in ubiquinone-mediated protein destruction necessary for cell-cycle through the G1 and S phases. Nevertheless, cullin-1, but not other members of the cullin family, is responsible for cell proliferation and differentiation [53]. It is believe that melatonin may effect on expansion of tumor by intermediating with binding of calcium and preventing the MAPs/calmodulin and tubulin/calmodulin complexes formation to stop degradation of cytoskeletal [54]. Peutz-Jeghers syndrome, which is associated with high risk of tumor development in multiple localizations is associated with at least one of these, Stk11 kinase with an unclear function, has anticarcinogenic effects and mutations [55]. Eventually, these data present undeviating evidence for the different effect of melatonin on the expression of different genes in vivo. Specific gene expression profiles are connected with the aging process in animals and humans [12]. Lund et al. [56] have detected a reduction in gene expression of heat shock protein while an elevation in the insulin-like genes expression, resulting in a decline in gene expression of insulin signaling during aging. Pletscher et al. [57], showed that down regulation of a large number of genes implicated in cell growth and maintenance following caloric restriction. Weindruch et al. [58], declared that in mice, the process of aging is describe by the high level of reactive oxygen species in both the skeletal muscle and brain, inhibition in the genes expression of biosynthetic enzyme and genes implicated in turnover of protein. Hence, caloric restriction stimulated genes are implicated in the metabolism of fatty acid, glycolysis, and gluconeogenesis. Presented results on the melatonin effects on gene expression, mainly genes of mitochondria, suggest that some of them may be accountable for the hormone capacity to block disorders resulting from aging. Further studies are need in this direction.
\nPattern of melatonin secretion, mediated by photoperiod, directly affect reproductive function which was recorded in several evidence-based researches. The daily light/dark (LD) cycle is considered the main physiological melatonin role, so, the variation in the duration of signal of melatonin occurs in attribution to the night length. The variation in melatonin signal duration is used to synchronize neuroendocrine rhythms with the annual variation in day-length in seasonal mammals. In addition, fetal and newborn animals use the maternal signal of melatonin to entrain endogenous circadian rhythms before direct photic information is presented. It was found that, very marked effect for exogenous melatonin was detected in modulating reproductive function in different organisms, depending on the animal age, melatonin supplementation time [59].
\nThe data presented above exhibited that the antigonadal effects of melatonin in humans are apparently much less significant than in some seasonally breeding mammalian species. This is due to humans are not ‘seasonally breeding’. Recently, accumulated evidences declared the efficacy of melatonin in attenuation the reproductive function in human. The suppressive effect of melatonin at the level of CNS have decreased daring growth. During development of human, such suppressive action of melatonin on GnRH function gradually reduced due to a down regulation in the functional of melatonin receptors expression. In other adult rodents, melatonin does not have noticeable action on the functioning of pituitary, whereas the association between the release of melatonin release and the functions of hypothalamic, involving the release of GnRH, are right. These actions are markedly significant in coinciding the external photoperiods and functions of reproduction through well not characterized mechanisms. The circadian rhythm regulated genes are considered seriously players in regulation of gene throughout different organism, especially for regulatory genes of cell-cycle and apoptotic genes. Melatonin may have also ameliorating effectiveness against human disorders attributed to reproductive function. Such as illumination intensity during the night actually decreases circulating levels of melatonin and reconstruct the suprachiasmatic nuclei circadian pacemaker, leading to the elevation in risk of breast cancer, which may be due to down-regulating gonadal synthesis of steroids, by acting on receptor sites within the neuroendocrine reproductive axis or altered estrogen receptor function [59]. Consequently, in the right circumstances, melatonin may be quite beneficial for reproductive health.
\nDisorder in the system of dopamine has also been noticeably associated with psychosis and schizophrenia. Dopamine proceeds in the frontal lobe and regulating the information coming in from other parts of the brain. Normalization in the dopamine flow may produce interrupted or discontinuous cogitation as in schizophrenia. Schizophrenia is described by both ‘positive ‘(additional experience and behavior) and ‘negative symptoms’ (lack in experience or behavior). Symptoms of positive response are classifying under the psychosis term and identically involve disorders of illusions, deliriums, and intellect. Symptoms of negative response may involve unsuitable emotional manifestation, lack of speech and stimulus. Some drugs, as cocaine, prevent dopamine return into the brain, coherently, dopamine buildup in the synapse, producing drug-initiated psychosis or schizophrenia [1].
\nMelatonin can produce sleepiness if given during the day. Additional, side effects that have been documented upon melatonin supplementation including cramps of stomach, vertigo, a continuous pain in the head, touchiness, moodiness, reduced sexual desire, enlargement of breast in the men and reduction in the count of sperm.
\nSo, melatonin should not take during operating machine or drive. Further, melatonin could interrupt with human fertility and also melatonin should be not used for pregnant or nursing women. Utilization of melatonin by person who already have an augmentation level of melatonin as children, teenagers, pregnant and lactating women can result in melatonin overdose. MAOI drugs inhibit melatonin breakdown from the body, so people should not take melatonin with these drugs to prevent melatonin overdose.
\nMelatonin causes drug–drug interaction with antidepressants, such as Prozac (inhibitor of serotonin) or Nardil (inhibitor of monoamine oxidase). Melatonin Interaction with these kinds of drugs can produce heart attack, confusion, sweating, shaking, and fever, lack of coordination, elevated blood pressure, diarrhea, and convulsions [1].
\nMelatonin is considered as a potent geroprotector, anticarcinogen, and inhibitor of tumor growth in vivo and in vitro, and in some models it may induce tumors and promote tumor growth. An important mechanism of melatonin is its impact on hemopoiesis involves the stimulation of melatonin on opioid receptors of bone marrow. Hence, we confirm further experimental studies and clinical trials which are necessary to estimate both the effectiveness and the safety for humans. Some antioxidants, including natural ones (e.g., α-tocopherol), have both geroprotector and tumorigenic potential and could be potent anticarcinogens as well. The results of administration of melatonin to perimenopausal women are promising. There are no contradictions between data on the carcinogenic and anticarcinogenic potential of melatonin but there are real data on the adverse effects of melatonin. Melatonin might own some ameliorating actions on human disorders that are contributed to the reproductive function. Such as lighting intensity during the night decreased the levels of circulating melatonin resulting in high risk of breast cancer [60]. Therefore, in the optimum condition, melatonin may have significant beneficial reproductive effects.
\nEpidemiological studies concerning the association between body circadian melatonin levels and cancer incidence led to controversial results, which were either significant association or no association at all. The effects of melatonin on cancers have been investigated, with a focus on hormone-dependent cancers. Different experimental works have suggested the ameliorative effect of melatonin in numerous types of metastatic tumors, including breast, ovarian, prostate, oral, gastric, and colorectal cancers. The mechanisms contributed with this improvement role of melatonin include various pathways of molecular origin, which are implicated with the activity of antioxidant enzymes, attenuation of MT1 and MT2 melatonin receptors, apoptosis regulation, metabolism of tumor, angiogenesis inhibition, invasion and metastasis, and initiation of epigenetic alteration. In different clinical trials, melatonin exhibited the capability to augment the treatment effect of chemotherapeutic drugs, and might help in enhancing the cancer patient’s life quality. Collectively, melatonin is considered a promising hormone for cancers prevention and treatment. So, it could be concluded that extensive future work may be occur which involves the effect of melatonin on autophagy and mitophagy, other mechanisms of molecular origin implicated in its anticancer effect. Melatonin improves also chemotherapeutic drugs, which should be further determined on a large scale of drugs. The oncostatic effects of melatonin on some type of cancers, dosage and safety of long-term supplementation of melatonin must be also further elucidated.
\nThe authors declared no conflict of interest.
IntechOpen celebrates Open Access academic research of women scientists: Call Opens on February 11, 2018 and closes on March 8th, 2018.
",metaTitle:'Call for Applications: "IntechOpen Women in Science 2018" Book Collection',metaDescription:"IntechOpen celebrates Open Access academic research of women scientists: Call Opens on February 11, 2018 and closes on March 8th, 2018.",metaKeywords:null,canonicalURL:"/page/women-in-science-book-collection-2018/",contentRaw:'[{"type":"htmlEditorComponent","content":"On February 9th, 2018, which marks the official celebration of UNESCO’s International Day of Women and Girls in Science, we have announced we are seeking contributors for the upcoming “IntechOpen Women in Science 2018” Book Collection. The program aims to support women scientists worldwide whose academic needs include quality assurance, peer-review, fast publishing, collaboration among complementary authors, immediate exposure, and post-publishing citations reporting.
\\n\\nAPPLYING FOR THE “INTECHOPEN WOMEN IN SCIENCE 2018” OPEN ACCESS BOOK COLLECTION
\\n\\nWomen scientists can apply for one book topic, either as an editor or with co-editors, for a publication of an OA book in any of the scientific categories that will be evaluated by The Women in Science Book Collection Committee, led by IntechOpen’s Editorial Board. Submitted proposals will be sent to designated members of the IntechOpen Editorial Advisory Board who will evaluate proposals based on the following parameters: the proposal’s originality, the topic’s relation to recent trends in the corresponding scientific field, and significance to the scientific community.
\\n\\nThe submissions are now closed. All applicants will be notified on the results in due time. Thank you for participating!
\\n"}]'},components:[{type:"htmlEditorComponent",content:"On February 9th, 2018, which marks the official celebration of UNESCO’s International Day of Women and Girls in Science, we have announced we are seeking contributors for the upcoming “IntechOpen Women in Science 2018” Book Collection. The program aims to support women scientists worldwide whose academic needs include quality assurance, peer-review, fast publishing, collaboration among complementary authors, immediate exposure, and post-publishing citations reporting.
\n\nAPPLYING FOR THE “INTECHOPEN WOMEN IN SCIENCE 2018” OPEN ACCESS BOOK COLLECTION
\n\nWomen scientists can apply for one book topic, either as an editor or with co-editors, for a publication of an OA book in any of the scientific categories that will be evaluated by The Women in Science Book Collection Committee, led by IntechOpen’s Editorial Board. Submitted proposals will be sent to designated members of the IntechOpen Editorial Advisory Board who will evaluate proposals based on the following parameters: the proposal’s originality, the topic’s relation to recent trends in the corresponding scientific field, and significance to the scientific community.
\n\nThe submissions are now closed. All applicants will be notified on the results in due time. Thank you for participating!
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{sort:"featured,name"},profiles:[{id:"6700",title:"Dr.",name:"Abbass A.",middleName:null,surname:"Hashim",slug:"abbass-a.-hashim",fullName:"Abbass A. Hashim",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/6700/images/1864_n.jpg",biography:"Currently I am carrying out research in several areas of interest, mainly covering work on chemical and bio-sensors, semiconductor thin film device fabrication and characterisation.\nAt the moment I have very strong interest in radiation environmental pollution and bacteriology treatment. The teams of researchers are working very hard to bring novel results in this field. I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. I have served as the editor for many books, been a member of the editorial board in science journals, have published many papers and hold many patents.",institutionString:null,institution:{name:"Sheffield Hallam University",country:{name:"United Kingdom"}}},{id:"54525",title:"Prof.",name:"Abdul Latif",middleName:null,surname:"Ahmad",slug:"abdul-latif-ahmad",fullName:"Abdul Latif Ahmad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"20567",title:"Prof.",name:"Ado",middleName:null,surname:"Jorio",slug:"ado-jorio",fullName:"Ado Jorio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal de Minas Gerais",country:{name:"Brazil"}}},{id:"47940",title:"Dr.",name:"Alberto",middleName:null,surname:"Mantovani",slug:"alberto-mantovani",fullName:"Alberto Mantovani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12392/images/7282_n.png",biography:"Alex Lazinica is the founder and CEO of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his PhD studies in Robotics at the Vienna University of Technology. Here he worked as a robotic researcher with the university's Intelligent Manufacturing Systems Group as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and most importantly he co-founded and built the International Journal of Advanced Robotic Systems- world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career, since it was a pathway to founding IntechOpen - Open Access publisher focused on addressing academic researchers needs. Alex is a personification of IntechOpen key values being trusted, open and entrepreneurial. Today his focus is on defining the growth and development strategy for the company.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"19816",title:"Prof.",name:"Alexander",middleName:null,surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19816/images/1607_n.jpg",biography:"Alexander I. Kokorin: born: 1947, Moscow; DSc., PhD; Principal Research Fellow (Research Professor) of Department of Kinetics and Catalysis, N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.\r\nArea of research interests: physical chemistry of complex-organized molecular and nanosized systems, including polymer-metal complexes; the surface of doped oxide semiconductors. He is an expert in structural, absorptive, catalytic and photocatalytic properties, in structural organization and dynamic features of ionic liquids, in magnetic interactions between paramagnetic centers. The author or co-author of 3 books, over 200 articles and reviews in scientific journals and books. He is an actual member of the International EPR/ESR Society, European Society on Quantum Solar Energy Conversion, Moscow House of Scientists, of the Board of Moscow Physical Society.",institutionString:null,institution:{name:"Semenov Institute of Chemical Physics",country:{name:"Russia"}}},{id:"62389",title:"PhD.",name:"Ali Demir",middleName:null,surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62389/images/3413_n.jpg",biography:"Dr. Ali Demir Sezer has a Ph.D. from Pharmaceutical Biotechnology at the Faculty of Pharmacy, University of Marmara (Turkey). He is the member of many Pharmaceutical Associations and acts as a reviewer of scientific journals and European projects under different research areas such as: drug delivery systems, nanotechnology and pharmaceutical biotechnology. Dr. Sezer is the author of many scientific publications in peer-reviewed journals and poster communications. Focus of his research activity is drug delivery, physico-chemical characterization and biological evaluation of biopolymers micro and nanoparticles as modified drug delivery system, and colloidal drug carriers (liposomes, nanoparticles etc.).",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"61051",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"100762",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"St David's Medical Center",country:{name:"United States of America"}}},{id:"107416",title:"Dr.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Texas Cardiac Arrhythmia",country:{name:"United States of America"}}},{id:"64434",title:"Dr.",name:"Angkoon",middleName:null,surname:"Phinyomark",slug:"angkoon-phinyomark",fullName:"Angkoon Phinyomark",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/64434/images/2619_n.jpg",biography:"My name is Angkoon Phinyomark. I received a B.Eng. degree in Computer Engineering with First Class Honors in 2008 from Prince of Songkla University, Songkhla, Thailand, where I received a Ph.D. degree in Electrical Engineering. My research interests are primarily in the area of biomedical signal processing and classification notably EMG (electromyography signal), EOG (electrooculography signal), and EEG (electroencephalography signal), image analysis notably breast cancer analysis and optical coherence tomography, and rehabilitation engineering. I became a student member of IEEE in 2008. During October 2011-March 2012, I had worked at School of Computer Science and Electronic Engineering, University of Essex, Colchester, Essex, United Kingdom. In addition, during a B.Eng. I had been a visiting research student at Faculty of Computer Science, University of Murcia, Murcia, Spain for three months.\n\nI have published over 40 papers during 5 years in refereed journals, books, and conference proceedings in the areas of electro-physiological signals processing and classification, notably EMG and EOG signals, fractal analysis, wavelet analysis, texture analysis, feature extraction and machine learning algorithms, and assistive and rehabilitative devices. I have several computer programming language certificates, i.e. Sun Certified Programmer for the Java 2 Platform 1.4 (SCJP), Microsoft Certified Professional Developer, Web Developer (MCPD), Microsoft Certified Technology Specialist, .NET Framework 2.0 Web (MCTS). I am a Reviewer for several refereed journals and international conferences, such as IEEE Transactions on Biomedical Engineering, IEEE Transactions on Industrial Electronics, Optic Letters, Measurement Science Review, and also a member of the International Advisory Committee for 2012 IEEE Business Engineering and Industrial Applications and 2012 IEEE Symposium on Business, Engineering and Industrial Applications.",institutionString:null,institution:{name:"Joseph Fourier University",country:{name:"France"}}},{id:"55578",title:"Dr.",name:"Antonio",middleName:null,surname:"Jurado-Navas",slug:"antonio-jurado-navas",fullName:"Antonio Jurado-Navas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/55578/images/4574_n.png",biography:"Antonio Jurado-Navas received the M.S. degree (2002) and the Ph.D. degree (2009) in Telecommunication Engineering, both from the University of Málaga (Spain). He first worked as a consultant at Vodafone-Spain. From 2004 to 2011, he was a Research Assistant with the Communications Engineering Department at the University of Málaga. In 2011, he became an Assistant Professor in the same department. From 2012 to 2015, he was with Ericsson Spain, where he was working on geo-location\ntools for third generation mobile networks. Since 2015, he is a Marie-Curie fellow at the Denmark Technical University. His current research interests include the areas of mobile communication systems and channel modeling in addition to atmospheric optical communications, adaptive optics and statistics",institutionString:null,institution:{name:"University of Malaga",country:{name:"Spain"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:5766},{group:"region",caption:"Middle and South America",value:2,count:5227},{group:"region",caption:"Africa",value:3,count:1717},{group:"region",caption:"Asia",value:4,count:10367},{group:"region",caption:"Australia and Oceania",value:5,count:897},{group:"region",caption:"Europe",value:6,count:15789}],offset:12,limit:12,total:118188},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"dateEndThirdStepPublish"},books:[{type:"book",id:"10270",title:"Fog Computing",subtitle:null,isOpenForSubmission:!0,hash:"54853b3034f0348a6157b5591f8d95f3",slug:null,bookSignature:"Dr. Isiaka Ajewale Alimi, Dr. Nelson Muga, Dr. Qin Xin and Dr. Paulo P. Monteiro",coverURL:"https://cdn.intechopen.com/books/images_new/10270.jpg",editedByType:null,editors:[{id:"208236",title:"Dr.",name:"Isiaka",surname:"Alimi",slug:"isiaka-alimi",fullName:"Isiaka Alimi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9662",title:"Vegetation Index and Dynamics",subtitle:null,isOpenForSubmission:!0,hash:"0abf2a59ee63fc1ba4fb64d77c9b1be7",slug:null,bookSignature:"Dr. Eusebio Cano Carmona, Dr. Ricardo Quinto Canas, Dr. Ana Cano Ortiz and Dr. Carmelo Maria Musarella",coverURL:"https://cdn.intechopen.com/books/images_new/9662.jpg",editedByType:null,editors:[{id:"87846",title:"Dr.",name:"Eusebio",surname:"Cano Carmona",slug:"eusebio-cano-carmona",fullName:"Eusebio Cano Carmona"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10543",title:"Psychology and Patho-physiological Outcomes of Eating",subtitle:null,isOpenForSubmission:!0,hash:"2464b5fb6a39df380e935096743410a0",slug:null,bookSignature:"Dr. Akikazu Takada and Dr. Hubertus Himmerich",coverURL:"https://cdn.intechopen.com/books/images_new/10543.jpg",editedByType:null,editors:[{id:"248459",title:"Dr.",name:"Akikazu",surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9659",title:"Fibroblasts - Advances in Cancer, Autoimmunity and Inflammation",subtitle:null,isOpenForSubmission:!0,hash:"926fa6446f6befbd363fc74971a56de2",slug:null,bookSignature:"Ph.D. Mojca Frank Bertoncelj and Ms. Katja Lakota",coverURL:"https://cdn.intechopen.com/books/images_new/9659.jpg",editedByType:null,editors:[{id:"328755",title:"Ph.D.",name:"Mojca",surname:"Frank Bertoncelj",slug:"mojca-frank-bertoncelj",fullName:"Mojca Frank Bertoncelj"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10536",title:"Campylobacter",subtitle:null,isOpenForSubmission:!0,hash:"c4b132b741dd0a2ed539b824ab63965f",slug:null,bookSignature:"Dr. Guillermo Téllez and Associate Prof. Saeed El-Ashram",coverURL:"https://cdn.intechopen.com/books/images_new/10536.jpg",editedByType:null,editors:[{id:"73465",title:"Dr.",name:"Guillermo",surname:"Téllez",slug:"guillermo-tellez",fullName:"Guillermo Téllez"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!0,hash:"a5308884068cc53ed31c6baba756857f",slug:null,bookSignature:"Dr. Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:null,editors:[{id:"165328",title:"Dr.",name:"Vahid",surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10765",title:"Environmental Management",subtitle:null,isOpenForSubmission:!0,hash:"e5ba02fedd7c87f0ab66414f3b07de0c",slug:null,bookSignature:"Dr. John P. Tiefenbacher",coverURL:"https://cdn.intechopen.com/books/images_new/10765.jpg",editedByType:null,editors:[{id:"73876",title:"Dr.",name:"John P.",surname:"Tiefenbacher",slug:"john-p.-tiefenbacher",fullName:"John P. Tiefenbacher"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10567",title:"Uncertainty Management in Engineering - Topics in Pollution Prevention and Controls",subtitle:null,isOpenForSubmission:!0,hash:"4990db602d31f1848c590dbfe97b6409",slug:null,bookSignature:"Prof. Rehab O. Abdel Rahman and Dr. Yung-Tse Hung",coverURL:"https://cdn.intechopen.com/books/images_new/10567.jpg",editedByType:null,editors:[{id:"92718",title:"Prof.",name:"Rehab",surname:"Abdel Rahman",slug:"rehab-abdel-rahman",fullName:"Rehab Abdel Rahman"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8977",title:"Protein Kinase - New Opportunities, Challenges and Future Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"6d200cc031706a565b554fdb1c478901",slug:null,bookSignature:"Dr. Rajesh Kumar Singh",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",editedByType:null,editors:[{id:"329385",title:"Dr.",name:"Rajesh",surname:"Singh",slug:"rajesh-singh",fullName:"Rajesh Singh"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10582",title:"Chemical Vapor Deposition",subtitle:null,isOpenForSubmission:!0,hash:"f9177ff0e61198735fb86a81303259d0",slug:null,bookSignature:"Dr. Sadia Ameen, Dr. M. Shaheer Akhtar and Prof. Hyung-Shik Shin",coverURL:"https://cdn.intechopen.com/books/images_new/10582.jpg",editedByType:null,editors:[{id:"52613",title:"Dr.",name:"Sadia",surname:"Ameen",slug:"sadia-ameen",fullName:"Sadia Ameen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10814",title:"Anxiety, Uncertainty, and Resilience During the Pandemic Period - Anthropological and Psychological Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"2db4d2a6638d2c66f7a5741d0f8fe4ae",slug:null,bookSignature:"Prof. Fabio Gabrielli and Dr. Floriana Irtelli",coverURL:"https://cdn.intechopen.com/books/images_new/10814.jpg",editedByType:null,editors:[{id:"259407",title:"Prof.",name:"Fabio",surname:"Gabrielli",slug:"fabio-gabrielli",fullName:"Fabio Gabrielli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10519",title:"Middleware Architecture",subtitle:null,isOpenForSubmission:!0,hash:"c326d436ae0f4c508849d2336dbdfb48",slug:null,bookSignature:"Dr. Mehdia Ajana El Khaddar",coverURL:"https://cdn.intechopen.com/books/images_new/10519.jpg",editedByType:null,editors:[{id:"26677",title:"Dr.",name:"Mehdia",surname:"Ajana El Khaddar",slug:"mehdia-ajana-el-khaddar",fullName:"Mehdia Ajana El Khaddar"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:14},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:3},{group:"topic",caption:"Business, Management and Economics",value:7,count:1},{group:"topic",caption:"Chemistry",value:8,count:7},{group:"topic",caption:"Computer and Information Science",value:9,count:6},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:7},{group:"topic",caption:"Engineering",value:11,count:15},{group:"topic",caption:"Environmental Sciences",value:12,count:2},{group:"topic",caption:"Immunology and Microbiology",value:13,count:3},{group:"topic",caption:"Materials Science",value:14,count:5},{group:"topic",caption:"Mathematics",value:15,count:1},{group:"topic",caption:"Medicine",value:16,count:24},{group:"topic",caption:"Neuroscience",value:18,count:1},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:2},{group:"topic",caption:"Physics",value:20,count:2},{group:"topic",caption:"Psychology",value:21,count:4},{group:"topic",caption:"Social Sciences",value:23,count:2},{group:"topic",caption:"Technology",value:24,count:1},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:1}],offset:12,limit:12,total:101},popularBooks:{featuredBooks:[{type:"book",id:"9385",title:"Renewable Energy",subtitle:"Technologies and Applications",isOpenForSubmission:!1,hash:"a6b446d19166f17f313008e6c056f3d8",slug:"renewable-energy-technologies-and-applications",bookSignature:"Tolga Taner, Archana Tiwari and Taha Selim Ustun",coverURL:"https://cdn.intechopen.com/books/images_new/9385.jpg",editors:[{id:"197240",title:"Associate Prof.",name:"Tolga",middleName:null,surname:"Taner",slug:"tolga-taner",fullName:"Tolga Taner"}],equalEditorOne:{id:"186791",title:"Dr.",name:"Archana",middleName:null,surname:"Tiwari",slug:"archana-tiwari",fullName:"Archana Tiwari",profilePictureURL:"https://mts.intechopen.com/storage/users/186791/images/system/186791.jpg",biography:"Dr. Archana Tiwari is Associate Professor at Amity University, India. Her research interests include renewable sources of energy from microalgae and further utilizing the residual biomass for the generation of value-added products, bioremediation through microalgae and microbial consortium, antioxidative enzymes and stress, and nutraceuticals from microalgae. She has been working on algal biotechnology for the last two decades. She has published her research in many international journals and has authored many books and chapters with renowned publishing houses. She has also delivered talks as an invited speaker at many national and international conferences. Dr. Tiwari is the recipient of several awards including Researcher of the Year and Distinguished Scientist.",institutionString:"Amity University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Amity University",institutionURL:null,country:{name:"India"}}},equalEditorTwo:{id:"197609",title:"Prof.",name:"Taha Selim",middleName:null,surname:"Ustun",slug:"taha-selim-ustun",fullName:"Taha Selim Ustun",profilePictureURL:"https://mts.intechopen.com/storage/users/197609/images/system/197609.jpeg",biography:"Dr. Taha Selim Ustun received a Ph.D. in Electrical Engineering from Victoria University, Melbourne, Australia. He is a researcher with the Fukushima Renewable Energy Institute, AIST (FREA), where he leads the Smart Grid Cybersecurity Laboratory. Prior to that, he was a faculty member with the School of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. His current research interests include power systems protection, communication in power networks, distributed generation, microgrids, electric vehicle integration, and cybersecurity in smart grids. He serves on the editorial boards of IEEE Access, IEEE Transactions on Industrial Informatics, Energies, Electronics, Electricity, World Electric Vehicle and Information journals. Dr. Ustun is a member of the IEEE 2004 and 2800, IEC Renewable Energy Management WG 8, and IEC TC 57 WG17. He has been invited to run specialist courses in Africa, India, and China. He has delivered talks for the Qatar Foundation, the World Energy Council, the Waterloo Global Science Initiative, and the European Union Energy Initiative (EUEI). His research has attracted funding from prestigious programs in Japan, Australia, the European Union, and North America.",institutionString:"Fukushima Renewable Energy Institute, AIST (FREA)",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"National Institute of Advanced Industrial Science and Technology",institutionURL:null,country:{name:"Japan"}}},equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8985",title:"Natural Resources Management and Biological Sciences",subtitle:null,isOpenForSubmission:!1,hash:"5c2e219a6c021a40b5a20c041dea88c4",slug:"natural-resources-management-and-biological-sciences",bookSignature:"Edward R. Rhodes and Humood Naser",coverURL:"https://cdn.intechopen.com/books/images_new/8985.jpg",editors:[{id:"280886",title:"Prof.",name:"Edward R",middleName:null,surname:"Rhodes",slug:"edward-r-rhodes",fullName:"Edward R Rhodes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9027",title:"Human Blood Group Systems and Haemoglobinopathies",subtitle:null,isOpenForSubmission:!1,hash:"d00d8e40b11cfb2547d1122866531c7e",slug:"human-blood-group-systems-and-haemoglobinopathies",bookSignature:"Osaro Erhabor and Anjana Munshi",coverURL:"https://cdn.intechopen.com/books/images_new/9027.jpg",editors:[{id:"35140",title:null,name:"Osaro",middleName:null,surname:"Erhabor",slug:"osaro-erhabor",fullName:"Osaro Erhabor"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7841",title:"New Insights Into Metabolic Syndrome",subtitle:null,isOpenForSubmission:!1,hash:"ef5accfac9772b9e2c9eff884f085510",slug:"new-insights-into-metabolic-syndrome",bookSignature:"Akikazu Takada",coverURL:"https://cdn.intechopen.com/books/images_new/7841.jpg",editors:[{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8558",title:"Aerodynamics",subtitle:null,isOpenForSubmission:!1,hash:"db7263fc198dfb539073ba0260a7f1aa",slug:"aerodynamics",bookSignature:"Mofid Gorji-Bandpy and Aly-Mousaad Aly",coverURL:"https://cdn.intechopen.com/books/images_new/8558.jpg",editors:[{id:"35542",title:"Prof.",name:"Mofid",middleName:null,surname:"Gorji-Bandpy",slug:"mofid-gorji-bandpy",fullName:"Mofid Gorji-Bandpy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9668",title:"Chemistry and Biochemistry of Winemaking, Wine Stabilization and Aging",subtitle:null,isOpenForSubmission:!1,hash:"c5484276a314628acf21ec1bdc3a86b9",slug:"chemistry-and-biochemistry-of-winemaking-wine-stabilization-and-aging",bookSignature:"Fernanda Cosme, Fernando M. Nunes and Luís Filipe-Ribeiro",coverURL:"https://cdn.intechopen.com/books/images_new/9668.jpg",editors:[{id:"186819",title:"Prof.",name:"Fernanda",middleName:null,surname:"Cosme",slug:"fernanda-cosme",fullName:"Fernanda Cosme"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7847",title:"Medical Toxicology",subtitle:null,isOpenForSubmission:!1,hash:"db9b65bea093de17a0855a1b27046247",slug:"medical-toxicology",bookSignature:"Pınar Erkekoglu and Tomohisa Ogawa",coverURL:"https://cdn.intechopen.com/books/images_new/7847.jpg",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoglu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8620",title:"Mining Techniques",subtitle:"Past, Present and Future",isOpenForSubmission:!1,hash:"b65658f81d14e9e57e49377869d3a575",slug:"mining-techniques-past-present-and-future",bookSignature:"Abhay Soni",coverURL:"https://cdn.intechopen.com/books/images_new/8620.jpg",editors:[{id:"271093",title:"Dr.",name:"Abhay",middleName:null,surname:"Soni",slug:"abhay-soni",fullName:"Abhay Soni"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9660",title:"Inland Waters",subtitle:"Dynamics and Ecology",isOpenForSubmission:!1,hash:"975c26819ceb11a926793bc2adc62bd6",slug:"inland-waters-dynamics-and-ecology",bookSignature:"Adam Devlin, Jiayi Pan and Mohammad Manjur Shah",coverURL:"https://cdn.intechopen.com/books/images_new/9660.jpg",editors:[{id:"280757",title:"Dr.",name:"Adam",middleName:"Thomas",surname:"Devlin",slug:"adam-devlin",fullName:"Adam Devlin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9122",title:"Cosmetic Surgery",subtitle:null,isOpenForSubmission:!1,hash:"207026ca4a4125e17038e770d00ee152",slug:"cosmetic-surgery",bookSignature:"Yueh-Bih Tang",coverURL:"https://cdn.intechopen.com/books/images_new/9122.jpg",editors:[{id:"202122",title:"Prof.",name:"Yueh-Bih",middleName:null,surname:"Tang",slug:"yueh-bih-tang",fullName:"Yueh-Bih Tang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9043",title:"Parenting",subtitle:"Studies by an Ecocultural and Transactional Perspective",isOpenForSubmission:!1,hash:"6d21066c7438e459e4c6fb13217a5c8c",slug:"parenting-studies-by-an-ecocultural-and-transactional-perspective",bookSignature:"Loredana Benedetto and Massimo Ingrassia",coverURL:"https://cdn.intechopen.com/books/images_new/9043.jpg",editors:[{id:"193200",title:"Prof.",name:"Loredana",middleName:null,surname:"Benedetto",slug:"loredana-benedetto",fullName:"Loredana Benedetto"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9731",title:"Oxidoreductase",subtitle:null,isOpenForSubmission:!1,hash:"852e6f862c85fc3adecdbaf822e64e6e",slug:"oxidoreductase",bookSignature:"Mahmoud Ahmed Mansour",coverURL:"https://cdn.intechopen.com/books/images_new/9731.jpg",editors:[{id:"224662",title:"Prof.",name:"Mahmoud Ahmed",middleName:null,surname:"Mansour",slug:"mahmoud-ahmed-mansour",fullName:"Mahmoud Ahmed Mansour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:5229},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10065",title:"Wavelet Theory",subtitle:null,isOpenForSubmission:!1,hash:"d8868e332169597ba2182d9b004d60de",slug:"wavelet-theory",bookSignature:"Somayeh Mohammady",coverURL:"https://cdn.intechopen.com/books/images_new/10065.jpg",editors:[{id:"109280",title:"Dr.",name:"Somayeh",middleName:null,surname:"Mohammady",slug:"somayeh-mohammady",fullName:"Somayeh Mohammady"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9644",title:"Glaciers and the Polar Environment",subtitle:null,isOpenForSubmission:!1,hash:"e8cfdc161794e3753ced54e6ff30873b",slug:"glaciers-and-the-polar-environment",bookSignature:"Masaki Kanao, Danilo Godone and Niccolò Dematteis",coverURL:"https://cdn.intechopen.com/books/images_new/9644.jpg",editors:[{id:"51959",title:"Dr.",name:"Masaki",middleName:null,surname:"Kanao",slug:"masaki-kanao",fullName:"Masaki Kanao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9385",title:"Renewable Energy",subtitle:"Technologies and Applications",isOpenForSubmission:!1,hash:"a6b446d19166f17f313008e6c056f3d8",slug:"renewable-energy-technologies-and-applications",bookSignature:"Tolga Taner, Archana Tiwari and Taha Selim Ustun",coverURL:"https://cdn.intechopen.com/books/images_new/9385.jpg",editors:[{id:"197240",title:"Associate Prof.",name:"Tolga",middleName:null,surname:"Taner",slug:"tolga-taner",fullName:"Tolga Taner"}],equalEditorOne:{id:"186791",title:"Dr.",name:"Archana",middleName:null,surname:"Tiwari",slug:"archana-tiwari",fullName:"Archana Tiwari",profilePictureURL:"https://mts.intechopen.com/storage/users/186791/images/system/186791.jpg",biography:"Dr. Archana Tiwari is Associate Professor at Amity University, India. Her research interests include renewable sources of energy from microalgae and further utilizing the residual biomass for the generation of value-added products, bioremediation through microalgae and microbial consortium, antioxidative enzymes and stress, and nutraceuticals from microalgae. She has been working on algal biotechnology for the last two decades. She has published her research in many international journals and has authored many books and chapters with renowned publishing houses. She has also delivered talks as an invited speaker at many national and international conferences. Dr. Tiwari is the recipient of several awards including Researcher of the Year and Distinguished Scientist.",institutionString:"Amity University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Amity University",institutionURL:null,country:{name:"India"}}},equalEditorTwo:{id:"197609",title:"Prof.",name:"Taha Selim",middleName:null,surname:"Ustun",slug:"taha-selim-ustun",fullName:"Taha Selim Ustun",profilePictureURL:"https://mts.intechopen.com/storage/users/197609/images/system/197609.jpeg",biography:"Dr. Taha Selim Ustun received a Ph.D. in Electrical Engineering from Victoria University, Melbourne, Australia. He is a researcher with the Fukushima Renewable Energy Institute, AIST (FREA), where he leads the Smart Grid Cybersecurity Laboratory. Prior to that, he was a faculty member with the School of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. His current research interests include power systems protection, communication in power networks, distributed generation, microgrids, electric vehicle integration, and cybersecurity in smart grids. He serves on the editorial boards of IEEE Access, IEEE Transactions on Industrial Informatics, Energies, Electronics, Electricity, World Electric Vehicle and Information journals. Dr. Ustun is a member of the IEEE 2004 and 2800, IEC Renewable Energy Management WG 8, and IEC TC 57 WG17. He has been invited to run specialist courses in Africa, India, and China. He has delivered talks for the Qatar Foundation, the World Energy Council, the Waterloo Global Science Initiative, and the European Union Energy Initiative (EUEI). His research has attracted funding from prestigious programs in Japan, Australia, the European Union, and North America.",institutionString:"Fukushima Renewable Energy Institute, AIST (FREA)",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"National Institute of Advanced Industrial Science and Technology",institutionURL:null,country:{name:"Japan"}}},equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8985",title:"Natural Resources Management and Biological Sciences",subtitle:null,isOpenForSubmission:!1,hash:"5c2e219a6c021a40b5a20c041dea88c4",slug:"natural-resources-management-and-biological-sciences",bookSignature:"Edward R. Rhodes and Humood Naser",coverURL:"https://cdn.intechopen.com/books/images_new/8985.jpg",editors:[{id:"280886",title:"Prof.",name:"Edward R",middleName:null,surname:"Rhodes",slug:"edward-r-rhodes",fullName:"Edward R Rhodes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9671",title:"Macrophages",subtitle:null,isOpenForSubmission:!1,hash:"03b00fdc5f24b71d1ecdfd75076bfde6",slug:"macrophages",bookSignature:"Hridayesh Prakash",coverURL:"https://cdn.intechopen.com/books/images_new/9671.jpg",editors:[{id:"287184",title:"Dr.",name:"Hridayesh",middleName:null,surname:"Prakash",slug:"hridayesh-prakash",fullName:"Hridayesh Prakash"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9313",title:"Clay Science and Technology",subtitle:null,isOpenForSubmission:!1,hash:"6fa7e70396ff10620e032bb6cfa6fb72",slug:"clay-science-and-technology",bookSignature:"Gustavo Morari Do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/9313.jpg",editors:[{id:"7153",title:"Prof.",name:"Gustavo",middleName:null,surname:"Morari Do Nascimento",slug:"gustavo-morari-do-nascimento",fullName:"Gustavo Morari Do Nascimento"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9888",title:"Nuclear Power Plants",subtitle:"The Processes from the Cradle to the Grave",isOpenForSubmission:!1,hash:"c2c8773e586f62155ab8221ebb72a849",slug:"nuclear-power-plants-the-processes-from-the-cradle-to-the-grave",bookSignature:"Nasser Awwad",coverURL:"https://cdn.intechopen.com/books/images_new/9888.jpg",editors:[{id:"145209",title:"Prof.",name:"Nasser",middleName:"S",surname:"Awwad",slug:"nasser-awwad",fullName:"Nasser Awwad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9027",title:"Human Blood Group Systems and Haemoglobinopathies",subtitle:null,isOpenForSubmission:!1,hash:"d00d8e40b11cfb2547d1122866531c7e",slug:"human-blood-group-systems-and-haemoglobinopathies",bookSignature:"Osaro Erhabor and Anjana Munshi",coverURL:"https://cdn.intechopen.com/books/images_new/9027.jpg",editors:[{id:"35140",title:null,name:"Osaro",middleName:null,surname:"Erhabor",slug:"osaro-erhabor",fullName:"Osaro Erhabor"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10432",title:"Casting Processes and Modelling of Metallic Materials",subtitle:null,isOpenForSubmission:!1,hash:"2c5c9df938666bf5d1797727db203a6d",slug:"casting-processes-and-modelling-of-metallic-materials",bookSignature:"Zakaria Abdallah and Nada Aldoumani",coverURL:"https://cdn.intechopen.com/books/images_new/10432.jpg",editors:[{id:"201670",title:"Dr.",name:"Zak",middleName:null,surname:"Abdallah",slug:"zak-abdallah",fullName:"Zak Abdallah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7841",title:"New Insights Into Metabolic Syndrome",subtitle:null,isOpenForSubmission:!1,hash:"ef5accfac9772b9e2c9eff884f085510",slug:"new-insights-into-metabolic-syndrome",bookSignature:"Akikazu Takada",coverURL:"https://cdn.intechopen.com/books/images_new/7841.jpg",editors:[{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"9550",title:"Entrepreneurship",subtitle:"Contemporary Issues",isOpenForSubmission:!1,hash:"9b4ac1ee5b743abf6f88495452b1e5e7",slug:"entrepreneurship-contemporary-issues",bookSignature:"Mladen Turuk",coverURL:"https://cdn.intechopen.com/books/images_new/9550.jpg",editedByType:"Edited by",editors:[{id:"319755",title:"Prof.",name:"Mladen",middleName:null,surname:"Turuk",slug:"mladen-turuk",fullName:"Mladen Turuk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10065",title:"Wavelet Theory",subtitle:null,isOpenForSubmission:!1,hash:"d8868e332169597ba2182d9b004d60de",slug:"wavelet-theory",bookSignature:"Somayeh Mohammady",coverURL:"https://cdn.intechopen.com/books/images_new/10065.jpg",editedByType:"Edited by",editors:[{id:"109280",title:"Dr.",name:"Somayeh",middleName:null,surname:"Mohammady",slug:"somayeh-mohammady",fullName:"Somayeh Mohammady"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9313",title:"Clay Science and Technology",subtitle:null,isOpenForSubmission:!1,hash:"6fa7e70396ff10620e032bb6cfa6fb72",slug:"clay-science-and-technology",bookSignature:"Gustavo Morari Do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/9313.jpg",editedByType:"Edited by",editors:[{id:"7153",title:"Prof.",name:"Gustavo",middleName:null,surname:"Morari Do Nascimento",slug:"gustavo-morari-do-nascimento",fullName:"Gustavo Morari Do Nascimento"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9888",title:"Nuclear Power Plants",subtitle:"The Processes from the Cradle to the Grave",isOpenForSubmission:!1,hash:"c2c8773e586f62155ab8221ebb72a849",slug:"nuclear-power-plants-the-processes-from-the-cradle-to-the-grave",bookSignature:"Nasser Awwad",coverURL:"https://cdn.intechopen.com/books/images_new/9888.jpg",editedByType:"Edited by",editors:[{id:"145209",title:"Prof.",name:"Nasser",middleName:"S",surname:"Awwad",slug:"nasser-awwad",fullName:"Nasser Awwad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8098",title:"Resources of Water",subtitle:null,isOpenForSubmission:!1,hash:"d251652996624d932ef7b8ed62cf7cfc",slug:"resources-of-water",bookSignature:"Prathna Thanjavur Chandrasekaran, Muhammad Salik Javaid, Aftab Sadiq",coverURL:"https://cdn.intechopen.com/books/images_new/8098.jpg",editedByType:"Edited by",editors:[{id:"167917",title:"Dr.",name:"Prathna",middleName:null,surname:"Thanjavur Chandrasekaran",slug:"prathna-thanjavur-chandrasekaran",fullName:"Prathna Thanjavur Chandrasekaran"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9644",title:"Glaciers and the Polar Environment",subtitle:null,isOpenForSubmission:!1,hash:"e8cfdc161794e3753ced54e6ff30873b",slug:"glaciers-and-the-polar-environment",bookSignature:"Masaki Kanao, Danilo Godone and Niccolò Dematteis",coverURL:"https://cdn.intechopen.com/books/images_new/9644.jpg",editedByType:"Edited by",editors:[{id:"51959",title:"Dr.",name:"Masaki",middleName:null,surname:"Kanao",slug:"masaki-kanao",fullName:"Masaki Kanao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10432",title:"Casting Processes and Modelling of Metallic Materials",subtitle:null,isOpenForSubmission:!1,hash:"2c5c9df938666bf5d1797727db203a6d",slug:"casting-processes-and-modelling-of-metallic-materials",bookSignature:"Zakaria Abdallah and Nada Aldoumani",coverURL:"https://cdn.intechopen.com/books/images_new/10432.jpg",editedByType:"Edited by",editors:[{id:"201670",title:"Dr.",name:"Zak",middleName:null,surname:"Abdallah",slug:"zak-abdallah",fullName:"Zak Abdallah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9671",title:"Macrophages",subtitle:null,isOpenForSubmission:!1,hash:"03b00fdc5f24b71d1ecdfd75076bfde6",slug:"macrophages",bookSignature:"Hridayesh Prakash",coverURL:"https://cdn.intechopen.com/books/images_new/9671.jpg",editedByType:"Edited by",editors:[{id:"287184",title:"Dr.",name:"Hridayesh",middleName:null,surname:"Prakash",slug:"hridayesh-prakash",fullName:"Hridayesh Prakash"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8415",title:"Extremophilic Microbes and Metabolites",subtitle:"Diversity, Bioprospecting and Biotechnological Applications",isOpenForSubmission:!1,hash:"93e0321bc93b89ff73730157738f8f97",slug:"extremophilic-microbes-and-metabolites-diversity-bioprospecting-and-biotechnological-applications",bookSignature:"Afef Najjari, Ameur Cherif, Haïtham Sghaier and Hadda Imene Ouzari",coverURL:"https://cdn.intechopen.com/books/images_new/8415.jpg",editedByType:"Edited by",editors:[{id:"196823",title:"Dr.",name:"Afef",middleName:null,surname:"Najjari",slug:"afef-najjari",fullName:"Afef Najjari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9731",title:"Oxidoreductase",subtitle:null,isOpenForSubmission:!1,hash:"852e6f862c85fc3adecdbaf822e64e6e",slug:"oxidoreductase",bookSignature:"Mahmoud Ahmed Mansour",coverURL:"https://cdn.intechopen.com/books/images_new/9731.jpg",editedByType:"Edited by",editors:[{id:"224662",title:"Prof.",name:"Mahmoud Ahmed",middleName:null,surname:"Mansour",slug:"mahmoud-ahmed-mansour",fullName:"Mahmoud Ahmed Mansour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"66",title:"Economic Development",slug:"economic-development",parent:{title:"Business, Management and Economics",slug:"business-management-and-economics"},numberOfBooks:5,numberOfAuthorsAndEditors:89,numberOfWosCitations:2,numberOfCrossrefCitations:12,numberOfDimensionsCitations:18,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicSlug:"economic-development",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10215",title:"Circular Economy",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"161dc2ffcd5ef7e5f8144938ed7fe477",slug:"circular-economy-recent-advances-new-perspectives-and-applications",bookSignature:"Tao Zhang",coverURL:"https://cdn.intechopen.com/books/images_new/10215.jpg",editedByType:"Edited by",editors:[{id:"185487",title:"Associate Prof.",name:"Tao",middleName:null,surname:"Zhang",slug:"tao-zhang",fullName:"Tao Zhang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9030",title:"Perspectives on Economic Development",subtitle:"Public Policy, Culture, and Economic Development",isOpenForSubmission:!1,hash:"8167ab72010ab459c0fc080da946ae8c",slug:"perspectives-on-economic-development-public-policy-culture-and-economic-development",bookSignature:"Ryan Merlin Yonk and Vito Bobek",coverURL:"https://cdn.intechopen.com/books/images_new/9030.jpg",editedByType:"Edited by",editors:[{id:"196259",title:"Dr.",name:"Ryan Merlin",middleName:null,surname:"Yonk",slug:"ryan-merlin-yonk",fullName:"Ryan Merlin Yonk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8150",title:"Elements of Bioeconomy",subtitle:null,isOpenForSubmission:!1,hash:"f5a930b0695ff23259fe96f219ff9a15",slug:"elements-of-bioeconomy",bookSignature:"Krzysztof Biernat",coverURL:"https://cdn.intechopen.com/books/images_new/8150.jpg",editedByType:"Edited by",editors:[{id:"155009",title:"Prof.",name:"Krzysztof",middleName:null,surname:"Biernat",slug:"krzysztof-biernat",fullName:"Krzysztof Biernat"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6008",title:"Taxes and Taxation Trends",subtitle:null,isOpenForSubmission:!1,hash:"ab59d9449969c67a1365d8b852094898",slug:"taxes-and-taxation-trends",bookSignature:"Jolanta Iwin-Garzy?ska",coverURL:"https://cdn.intechopen.com/books/images_new/6008.jpg",editedByType:"Edited by",editors:[{id:"203547",title:"Prof.",name:"Jolanta",middleName:null,surname:"Iwin-Garzyńska",slug:"jolanta-iwin-garzynska",fullName:"Jolanta Iwin-Garzyńska"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5819",title:"Research and Development Evolving Trends and Practices",subtitle:"Towards Human, Institutional and Economic Sectors Growth",isOpenForSubmission:!1,hash:"7e551ea4bdbca2454d3f7abb2837814d",slug:"research-and-development-evolving-trends-and-practices-towards-human-institutional-and-economic-sectors-growth",bookSignature:"Soha Maad",coverURL:"https://cdn.intechopen.com/books/images_new/5819.jpg",editedByType:"Edited by",editors:[{id:"7692",title:"Dr.",name:"Soha",middleName:null,surname:"Maad",slug:"soha-maad",fullName:"Soha Maad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:5,mostCitedChapters:[{id:"66110",doi:"10.5772/intechopen.84770",title:"Gold Recovery Process from Primary and Secondary Resources Using Bioadsorbents",slug:"gold-recovery-process-from-primary-and-secondary-resources-using-bioadsorbents",totalDownloads:1159,totalCrossrefCites:2,totalDimensionsCites:3,book:{slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Katsutoshi Inoue, Durga Parajuli, Manju Gurung, Bimala Pangeni, Kanjana Khunathai, Keisuke Ohto and Hidetaka Kawakita",authors:[{id:"198951",title:"Prof.",name:"Keisuke",middleName:null,surname:"Ohto",slug:"keisuke-ohto",fullName:"Keisuke Ohto"},{id:"259238",title:"Dr.",name:"Hidetaka",middleName:null,surname:"Kawakita",slug:"hidetaka-kawakita",fullName:"Hidetaka Kawakita"},{id:"289372",title:"Dr.",name:"Katsutoshi",middleName:null,surname:"Inoue",slug:"katsutoshi-inoue",fullName:"Katsutoshi Inoue"},{id:"298633",title:"Dr.",name:"Bimala",middleName:null,surname:"Pangeni",slug:"bimala-pangeni",fullName:"Bimala Pangeni"},{id:"298634",title:"Dr.",name:"Manju",middleName:null,surname:"Gurung",slug:"manju-gurung",fullName:"Manju Gurung"},{id:"298635",title:"Dr.",name:"Kanjana",middleName:null,surname:"Khunathai",slug:"kanjana-khunathai",fullName:"Kanjana Khunathai"},{id:"298636",title:"Dr.",name:"Durga",middleName:null,surname:"Parajuli",slug:"durga-parajuli",fullName:"Durga Parajuli"}]},{id:"68007",doi:"10.5772/intechopen.85036",title:"Overview of the Process of Enzymatic Transformation of Biomass",slug:"overview-of-the-process-of-enzymatic-transformation-of-biomass",totalDownloads:770,totalCrossrefCites:3,totalDimensionsCites:3,book:{slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Namita Singh, Anita Devi, Manju Bala Bishnoi, Rajneesh Jaryal, Avni Dahiya, Oleksandr Tashyrev and Vira Hovorukha",authors:[{id:"278205",title:"Prof.",name:"Namita",middleName:null,surname:"Singh",slug:"namita-singh",fullName:"Namita Singh"},{id:"282352",title:"Dr.",name:"Anita",middleName:null,surname:"Devi",slug:"anita-devi",fullName:"Anita Devi"},{id:"282353",title:"MSc.",name:"Avni",middleName:null,surname:"Dahiya",slug:"avni-dahiya",fullName:"Avni Dahiya"},{id:"282354",title:"MSc.",name:"Manju Bala",middleName:null,surname:"Bishnoi",slug:"manju-bala-bishnoi",fullName:"Manju Bala Bishnoi"},{id:"282355",title:"Dr.",name:"Oleksandr",middleName:null,surname:"Tashyrev",slug:"oleksandr-tashyrev",fullName:"Oleksandr Tashyrev"},{id:"282356",title:"Dr.",name:"Rajneesh",middleName:null,surname:"Jaryal",slug:"rajneesh-jaryal",fullName:"Rajneesh Jaryal"},{id:"282939",title:"Dr.",name:"Vira",middleName:null,surname:"Hovorukha",slug:"vira-hovorukha",fullName:"Vira Hovorukha"}]},{id:"55744",doi:"10.5772/intechopen.69369",title:"Smart Microgrids: Optimizing Local Resources toward Increased Efficiency and a More Sustainable Growth",slug:"smart-microgrids-optimizing-local-resources-toward-increased-efficiency-and-a-more-sustainable-growt",totalDownloads:778,totalCrossrefCites:0,totalDimensionsCites:2,book:{slug:"research-and-development-evolving-trends-and-practices-towards-human-institutional-and-economic-sectors-growth",title:"Research and Development Evolving Trends and Practices",fullTitle:"Research and Development Evolving Trends and Practices - Towards Human, Institutional and Economic Sectors Growth"},signatures:"Wilfried Elmenreich, Tamer Khatib and Andrea Monacchi",authors:[{id:"163771",title:"Dr.",name:"Wilfried",middleName:null,surname:"Elmenreich",slug:"wilfried-elmenreich",fullName:"Wilfried Elmenreich"},{id:"197214",title:"Dr.",name:"Andrea",middleName:null,surname:"Monacchi",slug:"andrea-monacchi",fullName:"Andrea Monacchi"}]}],mostDownloadedChaptersLast30Days:[{id:"59430",title:"Taxation and Economic Growth in a Resource-Rich Country: The Case of Nigeria",slug:"taxation-and-economic-growth-in-a-resource-rich-country-the-case-of-nigeria",totalDownloads:2439,totalCrossrefCites:0,totalDimensionsCites:0,book:{slug:"taxes-and-taxation-trends",title:"Taxes and Taxation Trends",fullTitle:"Taxes and Taxation Trends"},signatures:"Ojijo Odhiambo and Oluwatosin Olushola",authors:[{id:"203736",title:"Mr.",name:"Ojijo",middleName:null,surname:"Odhiambo",slug:"ojijo-odhiambo",fullName:"Ojijo Odhiambo"},{id:"206483",title:"Mr.",name:"Oluwatosin",middleName:null,surname:"Olushola",slug:"oluwatosin-olushola",fullName:"Oluwatosin Olushola"}]},{id:"66376",title:"Biotechnology in Agricultural Policies of Sub-Saharan Africa",slug:"biotechnology-in-agricultural-policies-of-sub-saharan-africa",totalDownloads:523,totalCrossrefCites:0,totalDimensionsCites:1,book:{slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Joel W. Ochieng and Anthony Ananga",authors:[{id:"74792",title:"Dr.",name:"Joel W.",middleName:null,surname:"Ochieng",slug:"joel-w.-ochieng",fullName:"Joel W. Ochieng"},{id:"299783",title:"Dr.",name:"Anthony",middleName:null,surname:"Ananga",slug:"anthony-ananga",fullName:"Anthony Ananga"}]},{id:"70993",title:"Economic, Social, and Environmental Dimensions of Development in Sudan",slug:"economic-social-and-environmental-dimensions-of-development-in-sudan",totalDownloads:363,totalCrossrefCites:0,totalDimensionsCites:0,book:{slug:"perspectives-on-economic-development-public-policy-culture-and-economic-development",title:"Perspectives on Economic Development",fullTitle:"Perspectives on Economic Development - Public Policy, Culture, and Economic Development"},signatures:"Elwasila Mohamed",authors:null},{id:"59443",title:"Tax Practitioner Compliance",slug:"tax-practitioner-compliance",totalDownloads:871,totalCrossrefCites:0,totalDimensionsCites:0,book:{slug:"taxes-and-taxation-trends",title:"Taxes and Taxation Trends",fullTitle:"Taxes and Taxation Trends"},signatures:"Minjo Kang",authors:[{id:"218836",title:"Dr.",name:"Minjo",middleName:null,surname:"Kang",slug:"minjo-kang",fullName:"Minjo Kang"}]},{id:"55744",title:"Smart Microgrids: Optimizing Local Resources toward Increased Efficiency and a More Sustainable Growth",slug:"smart-microgrids-optimizing-local-resources-toward-increased-efficiency-and-a-more-sustainable-growt",totalDownloads:775,totalCrossrefCites:0,totalDimensionsCites:2,book:{slug:"research-and-development-evolving-trends-and-practices-towards-human-institutional-and-economic-sectors-growth",title:"Research and Development Evolving Trends and Practices",fullTitle:"Research and Development Evolving Trends and Practices - Towards Human, Institutional and Economic Sectors Growth"},signatures:"Wilfried Elmenreich, Tamer Khatib and Andrea Monacchi",authors:[{id:"163771",title:"Dr.",name:"Wilfried",middleName:null,surname:"Elmenreich",slug:"wilfried-elmenreich",fullName:"Wilfried Elmenreich"},{id:"197214",title:"Dr.",name:"Andrea",middleName:null,surname:"Monacchi",slug:"andrea-monacchi",fullName:"Andrea Monacchi"}]},{id:"71401",title:"Budget Deficit and the Federal Government Debt in Malaysia",slug:"budget-deficit-and-the-federal-government-debt-in-malaysia",totalDownloads:411,totalCrossrefCites:1,totalDimensionsCites:1,book:{slug:"perspectives-on-economic-development-public-policy-culture-and-economic-development",title:"Perspectives on Economic Development",fullTitle:"Perspectives on Economic Development - Public Policy, Culture, and Economic Development"},signatures:"Mohamed Aslam and Raihan Jaafar",authors:null},{id:"68007",title:"Overview of the Process of Enzymatic Transformation of Biomass",slug:"overview-of-the-process-of-enzymatic-transformation-of-biomass",totalDownloads:767,totalCrossrefCites:3,totalDimensionsCites:3,book:{slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Namita Singh, Anita Devi, Manju Bala Bishnoi, Rajneesh Jaryal, Avni Dahiya, Oleksandr Tashyrev and Vira Hovorukha",authors:[{id:"278205",title:"Prof.",name:"Namita",middleName:null,surname:"Singh",slug:"namita-singh",fullName:"Namita Singh"},{id:"282352",title:"Dr.",name:"Anita",middleName:null,surname:"Devi",slug:"anita-devi",fullName:"Anita Devi"},{id:"282353",title:"MSc.",name:"Avni",middleName:null,surname:"Dahiya",slug:"avni-dahiya",fullName:"Avni Dahiya"},{id:"282354",title:"MSc.",name:"Manju Bala",middleName:null,surname:"Bishnoi",slug:"manju-bala-bishnoi",fullName:"Manju Bala Bishnoi"},{id:"282355",title:"Dr.",name:"Oleksandr",middleName:null,surname:"Tashyrev",slug:"oleksandr-tashyrev",fullName:"Oleksandr Tashyrev"},{id:"282356",title:"Dr.",name:"Rajneesh",middleName:null,surname:"Jaryal",slug:"rajneesh-jaryal",fullName:"Rajneesh Jaryal"},{id:"282939",title:"Dr.",name:"Vira",middleName:null,surname:"Hovorukha",slug:"vira-hovorukha",fullName:"Vira Hovorukha"}]},{id:"58324",title:"How Does a Welfare State achieves Fiscal Sustainability? A Study of the Impact of Tax Equity",slug:"how-does-a-welfare-state-achieves-fiscal-sustainability-a-study-of-the-impact-of-tax-equity",totalDownloads:819,totalCrossrefCites:0,totalDimensionsCites:0,book:{slug:"taxes-and-taxation-trends",title:"Taxes and Taxation Trends",fullTitle:"Taxes and Taxation Trends"},signatures:"Ko Hyejin",authors:[{id:"204292",title:"Ph.D.",name:"Hyejin",middleName:null,surname:"Ko",slug:"hyejin-ko",fullName:"Hyejin Ko"}]},{id:"66110",title:"Gold Recovery Process from Primary and Secondary Resources Using Bioadsorbents",slug:"gold-recovery-process-from-primary-and-secondary-resources-using-bioadsorbents",totalDownloads:1158,totalCrossrefCites:2,totalDimensionsCites:3,book:{slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Katsutoshi Inoue, Durga Parajuli, Manju Gurung, Bimala Pangeni, Kanjana Khunathai, Keisuke Ohto and Hidetaka Kawakita",authors:[{id:"198951",title:"Prof.",name:"Keisuke",middleName:null,surname:"Ohto",slug:"keisuke-ohto",fullName:"Keisuke Ohto"},{id:"259238",title:"Dr.",name:"Hidetaka",middleName:null,surname:"Kawakita",slug:"hidetaka-kawakita",fullName:"Hidetaka Kawakita"},{id:"289372",title:"Dr.",name:"Katsutoshi",middleName:null,surname:"Inoue",slug:"katsutoshi-inoue",fullName:"Katsutoshi Inoue"},{id:"298633",title:"Dr.",name:"Bimala",middleName:null,surname:"Pangeni",slug:"bimala-pangeni",fullName:"Bimala Pangeni"},{id:"298634",title:"Dr.",name:"Manju",middleName:null,surname:"Gurung",slug:"manju-gurung",fullName:"Manju Gurung"},{id:"298635",title:"Dr.",name:"Kanjana",middleName:null,surname:"Khunathai",slug:"kanjana-khunathai",fullName:"Kanjana Khunathai"},{id:"298636",title:"Dr.",name:"Durga",middleName:null,surname:"Parajuli",slug:"durga-parajuli",fullName:"Durga Parajuli"}]},{id:"67691",title:"The Use of Waste Management Techniques to Enhance Household Income and Reduce Urban Water Pollution",slug:"the-use-of-waste-management-techniques-to-enhance-household-income-and-reduce-urban-water-pollution",totalDownloads:484,totalCrossrefCites:1,totalDimensionsCites:1,book:{slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Olayiwola A. Akintola, Olufunmilayo O. Idowu, Suraju A. Lateef, Gbenga A. Adebayo, Adekemi O. Shokalu and Omolara I. Akinyoola",authors:[{id:"293178",title:"Dr.",name:"Olayiwola A.",middleName:null,surname:"Akintola",slug:"olayiwola-a.-akintola",fullName:"Olayiwola A. Akintola"},{id:"297217",title:"Dr.",name:"Olufunmilayo O.",middleName:null,surname:"Idowu",slug:"olufunmilayo-o.-idowu",fullName:"Olufunmilayo O. Idowu"},{id:"297218",title:"Dr.",name:"Suraju A.",middleName:null,surname:"Lateef",slug:"suraju-a.-lateef",fullName:"Suraju A. Lateef"},{id:"297219",title:"Dr.",name:"Gbenga A.",middleName:null,surname:"Adebayo",slug:"gbenga-a.-adebayo",fullName:"Gbenga A. Adebayo"},{id:"297221",title:"Dr.",name:"Adekemi O.",middleName:null,surname:"Shokalu",slug:"adekemi-o.-shokalu",fullName:"Adekemi O. Shokalu"},{id:"297222",title:"Mrs.",name:"Omolara I.",middleName:null,surname:"Akinyoola",slug:"omolara-i.-akinyoola",fullName:"Omolara I. Akinyoola"}]}],onlineFirstChaptersFilter:{topicSlug:"economic-development",limit:3,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[{type:"book",id:"10176",title:"Microgrids and Local Energy Systems",subtitle:null,isOpenForSubmission:!0,hash:"c32b4a5351a88f263074b0d0ca813a9c",slug:null,bookSignature:"Prof. Nick Jenkins",coverURL:"https://cdn.intechopen.com/books/images_new/10176.jpg",editedByType:null,editors:[{id:"55219",title:"Prof.",name:"Nick",middleName:null,surname:"Jenkins",slug:"nick-jenkins",fullName:"Nick Jenkins"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:8,limit:8,total:1},route:{name:"profile.detail",path:"/profiles/315275/nicky-kisku",hash:"",query:{},params:{id:"315275",slug:"nicky-kisku"},fullPath:"/profiles/315275/nicky-kisku",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()