Inventory of the volcanoes of the Jos Plateau, Nigeria.
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
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\r\n\tBiomimetics can be described as an innovative form of technology that imitates (or mimics) nature to improve human lives via creating desirable solutions. Indeed, it is the study of nature and natural phenomena, in an attempt to understand the principles and elucidate the underlying mechanisms, obtain ideas from nature, and apply concepts that may benefit science, engineering, pharmacy, dentistry, and medicine. Smart/Intelligent Biomaterials for tissue engineering and regenerative medicine is a fine example. Yet, biomimicry can go above and beyond the simplistic inspiration and use of natural properties as the basis for the innovation of new products. It bridges the gap between the lab and the industry, via the intra-disciplinary design and formulation of functional solutions combining knowledge, methods, techniques, and advances in the fields of chemistry, biology, architecture, engineering, medicine, pharmaceutics, dentistry, and biomedical engineering. Three-Dimensional Printing, Self-Healing nanoCoatings, biomechanical Carbon nanoTubes, Stimuli-sensitive and -responsive Cell/Drug Delivery Systems, and Robotics are good examples. Those are some of the topics that will be covered in this new book, with the objective to provide the interested reader, whether a student or an expert, with a practical reference approaching biomimetics from a realistic and translational perspective, discussing problems and offering solutions, via including studies from basics to the clinic to scale-up and industrial or go-to-market obstacles.
",isbn:"978-1-80356-897-3",printIsbn:"978-1-80356-896-6",pdfIsbn:"978-1-80356-898-0",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"173e62fa4d7bf5508cec3bdd8e3cb32d",bookSignature:"Prof. Ziyad S. Haidar",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11453.jpg",keywords:"BioMechanics, 3D Printing, BioInspired Chemistry, Adaptive Structure, Self-Healing, Bioinspired Thermal Control, Self-Organization, Visco-Elastic Materials, Artificial Intelligence, Implantable Devices, Molecule Recognition, In Vitro",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 5th 2022",dateEndSecondStepPublish:"June 16th 2022",dateEndThirdStepPublish:"August 15th 2022",dateEndFourthStepPublish:"November 3rd 2022",dateEndFifthStepPublish:"January 2nd 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"DDS, Cert Implantol, MSc OMFS, FRCS(C), with an MBA in HealthCare Organizations Management and Ph.D. in BioEngineering and nanoPharmaceuticals (McGill University, Montréal, Canada). Presently, a Full Professor, leading the BioMAT’X R&D&I HAIDAR LAB at the CiiB, UAndes, Santiago de Chile.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"222709",title:"Prof.",name:"Ziyad S.",middleName:null,surname:"Haidar",slug:"ziyad-s.-haidar",fullName:"Ziyad S. Haidar",profilePictureURL:"https://mts.intechopen.com/storage/users/222709/images/system/222709.jpg",biography:"Ziyad S. Haidar, DDS, Cert Implantol, MSC, FRCSc, MBA, Ph.D., is a Full Professor of Biomaterials and Tissue Engineering and the scientific director of the Facultad de Odontología (Faculty of Dentistry), Universidad de los Andes (UAndes), Santiago, Chile. He is also the founder and head of the Biomaterials, Pharmaceutical Delivery, and Cranio-Maxillo-Facial Tissue Engineering Laboratory (BioMAT\\'X R&D&I Chile – HAIDAR Lab). In addition, he serves as the head of innovation at the Centro de Investigación e Innovación Biomédica (CiiB), a faculty/theses member in the bioMedicine Doctoral (Ph.D. bioMedicina) Program at UAndes, and a visiting clinical and surgical professor at the MaxilloFacial Division of the Universidad de la Frontera and the Department of Head and Neck Surgery, Lautaru Hospital, both in Temuco, Chile.\n\nDr. Haidar is a trained dentist, implantologist, and an oral and maxillofacial surgeon with a Ph.D. in Nanobiomaterials, Pharmaceuticals, and Tissue Engineering from McGill University, Montréal, Canada. He completed a post-doctoral training residency in orthopedics at the Montréal Shriners Hospital, McGill University Health Center, Montréal, Canada. Before moving to Chile, he served as Associate Professor of Bioceramics and the Chair of Excellence in BioEngineering at the Université de Limoges, Limoges, France and was an assistant professor in the Department of Pharmaceutics and Pharmaceutical Chemistry (cross-appointment with the Department of BioEngineering), University of Utah, Salt Lake City, UT, USA. Between 2010 and 2012 Dr. Haidar served as an adjunct professor of Head and Neck Surgery and the scientific director of the joint Utah–Inha R&D Center, Inha University Hospital, Incheon, Seoul, South Korea. \n\nHe has won several prestigious awards from the International Bone and Mineral Society, Society for Biomaterials, Canadian Biomaterial Society, and the Canadian and Lebanese Societies of Plastic Surgeons, to name a few. His R&D&I focus on patient-oriented development and evaluation of bionanotechnology, biopolymers, bioceramics, and drug delivery systems for the repair, restoration, reconstruction, and regeneration of challenging craniofacial and orthopedic defects. Dr. Haidar is an international speaker with more than 125 publications, conference proceedings, textbooks, and patents to his credit. He is also an editorial board member of several national and international scientific journals and periodicals.",institutionString:"Universidad de los Andes, Santiago de Chile",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of the Andes",institutionURL:null,country:{name:"Chile"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"11",title:"Engineering",slug:"engineering"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"280415",firstName:"Josip",lastName:"Knapic",middleName:null,title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/280415/images/8050_n.jpg",email:"josip@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"10301",title:"Biomechanics and Functional Tissue Engineering",subtitle:null,isOpenForSubmission:!1,hash:"e4a8f12fb1e7fb4247e24710eefee7d1",slug:"biomechanics-and-functional-tissue-engineering",bookSignature:"Ziyad S. Haidar, Ibrokhim Y. Abdurakhmonov and Abdelwahed Barkaoui",coverURL:"https://cdn.intechopen.com/books/images_new/10301.jpg",editedByType:"Edited by",editors:[{id:"222709",title:"Prof.",name:"Ziyad S.",surname:"Haidar",slug:"ziyad-s.-haidar",fullName:"Ziyad S. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3828",title:"Application of Nanotechnology in Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"51a27e7adbfafcfedb6e9683f209cba4",slug:"application-of-nanotechnology-in-drug-delivery",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/3828.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"65639",title:"Is a Volcanic Eruption Possible in Nigeria?",doi:"10.5772/intechopen.84253",slug:"is-a-volcanic-eruption-possible-in-nigeria-",body:'An inventory of all the volcanic prone areas on the Jos and Biu Plateaux were carried out, followed by detailed update of the Geology of two major volcanic areas on the Jos Plateau volcanic provinces (Kassa and Kerang volcanoes). The geochemistry (major, trace and REEs compositions) of these volcanoes were determined and a few dating using 40Ar-39Ar technique were performed on the Kassa basalts. Hydrogeochemical investigations of the Pidong Volcanic Crater Lake have also been carried out to constraint the chemical element sources into the Lake. Also, 40Ar-39Ar dating of the basalts of the Kassa volcanic field has revealed young ages spanning from 2.5, 1.97, 1.66, 1.39 to 1.34 Ma confirming the recent but short interval and multiple successive episodes of eruptions associated with volcanic activity in the region. Similar ages in the range of 2.1–0.9 Ma have been reported from basaltic rocks from the Benue Trough and a dolerite dyke from the region [1]. These same range of ages (of 2.83–0 Ma) have been obtained on basaltic rocks from the near-by Cameroon Volcanic Line (CVL) [1]. The Jos Plateau basalts vary in composition from basalt proper to trachyandesitic varieties of alkaline basalt magma series and some tholeiitic affinity [2]. Contrarily to the general notion that volcanoes are only associated with plate margins alone, the volcanoes in Nigeria are emplaced within the continent, associated with mantle Hot Spots. Records of gas emissions at Lakes Monoun and Nyos in Cameroon Republic in 1984 and 1986 respectively destroyed lives and properties within 14 km radius to a large extent, affected some communities in Nigeria (Mambilla Plateau and Katsina-Ala River banks) [3]. This research attempts to provide answers as to whether it is possible that the dormant volcanoes in Nigeria with no recorded history of eruption could roar back to life? Some reported successive minor volcanic activities within the Cameroon Volcanic Line (CVL) (1909, 1922, 1954, 1959 and 1982) are pointers to the possibility of the reactivation of some dormant volcanoes in Nigeria.
An understanding of the geology is important in studying natural hazards related to volcanism because the geology influences tectonic movement which leads to the disequilibrium of the ecosystem and other environmental components.
The Nigeria-Cameroon Volcanic Provinces lie within the Pan-African collision belt of West Africa (Figure 1). In Nigeria, the volcanic provinces (Jos Plateau, Biu Plateau, Benue Valley, etc.) are confined to the northeastern and central regions [4]. The volcanic provinces are characterized by numerous volcanic cones and lava flows consisting of alkaline olivine basalts together with less important trachyte and phonolite intrusive rocks [5].
Locations of the Jos and Biu Plateaux Volcanic Provinces, Nigeria.
Apparently, the large volcanic province of Nigeria suggests that volcanic activity during the Quaternary, was intense on the Jos Plateau, the Benue trough and along the northeast to southwest Cameroon line. Like the Jos Plateau volcanic regions, most of the main volcanic provinces such as the Bamenda Highlands, the Mambilla Plateau and the Adamawa Plateau are characterized by basement uplift [5].
The Cameroon Volcanic Line which extends from the Gulf of Guinea, Island of Annobon, Sao Tome and Principe and Fernando Po splits into two branches, one extending into northern Nigeria forming the Biu Plateau while the other extending eastward forming the Ngoude Plateau of Eastern Cameroun (Figure 1). Thus, in Nigeria, the volcanic provinces occur as relicts of volcanism in the form of scattered volcanic plugs and cones in some cases [5]. On the relatively uplifted Jos Plateau region, volcanic rocks are represented by volcanic cones and calderas [2].
Some of these cones generally rise only few hundred meters above the Plateau surface and are steep-sided with a central crater which may measure up to 450 m usually emerging at a breached in the crater wall. They are mainly built of basaltic scoria, volcanic ash, lava and with some variety of inclusions.
Reconnaissance visits were carried out to past volcanic eruption sites where a careful and systematic mapping of each of the volcanoes visited were carried out so as to determine its nature, size and composition. Other information acquired was their physical surface weathering features, morphology, outcrop patterns and the extent of vegetation cover.
Rock samples were collected for petrography, geochemistry and geochronology. Both petrographic and geochemical studies were done in the Department of Geology, University of Jos, Nigeria. 40Ar-39Ar dating on the basalts was done in Netherlands, Geological Survey Laboratory. For quality control, a duplicate geochemical analysis on the same basaltic rocks was carried out at the University of Cardiff, Wales using the Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES).
A constant monitoring of the Pidong Crater Lake through continuous water sampling 24–36 calendar months was done. The following physical parameters were recorded in the field using MT 806/pH/EC/TDS/Temp portable meter (pH, Temperature, Electrical Conductivity (EC), Total Dissolved Solids (TDS)). The water samples were collected in 100 ml polyethylene plastic bottles for cations and anion analysis. The sample for cations analysis was acidified with 0.1 M Nitric acid to prevent precipitating and bacterial growth. The following cations: Mg, Ca, Na, K, Cr, Ni, Co, Sc, V, Cu, Pb, Zn, Bi, Cd, Sn, W, Ma, As, Sb, Rb, Cs, Ba, Sr., Ga, Li, Ta, Nb, Hf, Zr, Y, Th, U, B, Fe & REEs were analyzed using ICP-MS method at Bureau Veritas Minerals Laboratory Limited, Canada while the anions: SO4, Cl, HCO3, NO3, F, Br and PO4 were carried out using colometry method at Maxxam Laboratory, Vancouver, Canada (subsidiary of Bureau Veritas Ltd).
Oxygen-18 (∂18O) and deuterium (∂2H), and (∂3H) and Carbon-14 (14C) isotopes of the Pidong Crater Lake, Bwonpe Volcanic Spring and rainfall were analyzed at Activation Laboratory Ontario, Canada using cavity Ring down spectroscopy (CRDS) model L11 02-1 California, USA with V-SMOW standards with typical standards deviation for 18O ± 0.1% and 1% for Tritium unit (TU).
Field investigations have revealed the existence of about 22 dormant volcanoes on the Jos Plateau region alone (Table 1) and are generally aligned in series of NNW–SSE trend [6, 7, 8] (Figure 2). None of these volcanoes have record of any activity in recent past [8, 9]. They are composed mainly of basaltic scoria and pyroclastic materials.
S. No. | Name/locality | Coordinates | Estimated population of people at risk | Type of volcano | Diameter of crater | Elevation (ASL) | Materials deposited |
---|---|---|---|---|---|---|---|
1 | Bum | 200,000 | Cone | Basaltic | |||
2 | Jal | 150,000 | Cone | Basaltic | |||
3 | Kwakwi | 250,000 | Cone | Basaltic | |||
4 | Miango volcano I | N09°51′.365″; E008°43′.961″ | For 1 & 2 250,000 | Cone | 350 m | 1297 m | Scoraceous basalt/pyoclastics |
5 | Miango volcano II | N09 51. 000′; E008 44″. 191′ | Cone | 650 m | 1303 m | ‘’ | |
6 | Kassa volcanoes | Highest Peak: N09°36′.119″; E008°53′.521″ | 100,000 | Cluster (6 overlapping volcanoes) | Average 300 m | Average 1342 m | Olivine basalt, scoria, tuff, breccia/volcanic bomb |
7 | Sha 1 | N09° 10′. 543″;E008° 47′. 955″; | 20,000 | Dome | 200 m | 1310 m | Pyroclastics (granite fragments/lava) |
8 | Sha 2 | N09°10′. 846″;E008° 48′. 05″; | 10,000 | Dome | 200 m | 1294 m | Weathered basaltic materials capped by iron concretions |
9 | Passakai | N09° 10′. 543″;E008° 47′. 955″ | 10,000 | Dome | 300 m | 1375 m | Lateritized |
10 | Wushik (Lakas) volcano | N09° 24′ 165″; E009° 10′ 554″ | 10,500 | Cone | 250 m | 1300 m | Scoria/pyroclastics |
11 | Kogul (Nyeis) volcano | N09° 22′ 573″;E009° 11′ 068″ | 80,000 | Cone | 250 m | 1250 m | Scoria/pyroclastics |
12 | Kerang I | N09° 20′ 286″;E009° 11′ 643″; | I to IV put together 200,000 | Cone | 600 m | 1400 m | Scoria/basaltic rocks with large phenocrysts of olivine, garnet and pyroxene |
13 | Kerang II | N09° 20′ 392″;E009° 11′ 502″; | Cinder Cone | 1000 m | 1450 m | Scoria/basaltic rocks with large phenocrysts of olivine, garnet and pyroxene | |
14 | Kerang III volcano (Swan junction) | N09° 20′ 306″;E009° 10′ 561″ | Cone | 1000 m | 1486 m | Scoria/pyroclastics | |
15 | Kerang IV | N09° 11′ 283″;E008° 12′ 547″ | Cluster (with 2 craters) | 1.5 km | 1372 m | Pulverised basement and lava | |
16 | Pidong volcano | N09° 17′ 650″;E009° 12′ 312″ | 50,000 | Crater Lake | 700 m | 1378 m | Scoria/pyroclastics |
17 | Jiblik volcano | N09° 16′ 591″;E009° 16′ 890″ | 100,000 | Cinder Cone | 1 km | 1228 m | Scoraceous basalt +garnet/pyroclastics |
18 | Kagu volcano | N09° 13′ 901″; 008° 16′ 383″ | 50,000 | Cone | 1 km | 1060 m | Scoraceous basalt/pyroclastics |
19 | Katul volcano | N09° 11′ 264″;E009° 15′ 795″ | 5000 | Cone | 700 m | 976 m | Scoraceous basalt/pyroclastics |
20 | Lakdak | 7000 | cone | Scoraceous basalt/pyroclastics |
Inventory of the volcanoes of the Jos Plateau, Nigeria.
Geological map of the 22 dormant volcanoes of the Jos Plateau showing sample locations. M = Miango volcanoes, K = Kassa volcanoes, S = Sura volcanoes, and G = Gu volcanoes.
Tables 1 and 2 present the inventory of the dormant volcanoes on the Jos Plateau and the Biu Plateau, respectively. From the NNW end are the Ganawuri volcanic line, Hoss volcanic line, Panyam (Sura) volcanic line and Gu (Jiblik) volcanic line (Figure 2). The Ganawuri line comprises from the north to south of the Bum, Jal, and Kwakwi volcanoes. The Hoss volcanic line consists of two volcanoes; Miango in the north and Hoss volcano in the south. The Miango line consists of five volcanoes from the north to the south viz.: Rukuba, Miango north, Miango south, Vom and Kassa volcanoes. The Southern-most end members are namely the Panyam and Gu volcanic lines. The Panyam volcanic line consists of seven volcanoes aligned in a NNE–SSW trending directions along a hypothetical fracture line [6, 10]; Dai volcano (referred to as Wushik volcano), Amshel volcano (referred to as Kugol volcano), Dutsin volcano, Kerang volcano, Tingyaras volcano, Ampang volcano (referred to as Mufil volcano), Pidong Crater Lake.
S/No. | Name/locality | Coordinates | Estimated population of people at risk | Type of volcano | Diameter of crater | Elevation (asl) | Materials deposited |
---|---|---|---|---|---|---|---|
1 | Tasha Village | N10°17′388″ E011°24′406″ | 5000 | Cluster of 3 volcanic cones. | 50 m | 426 m asl | Massive basaltic rocks |
2 | After Tasha Village | N10° 16′.661″ E011° 27′.143″ | 5000 | Dome | 427 m | Massive/vesicular basaltic rocks | |
3 | Tagwaye (twin) volcanoes (In Kwaya Kusar LGA of Borno State) | N10° 30′.530″ E011° 30′.402″ | 15,000 | 2 Cones | 200 m | 512 m | Olivine basalts/ Agglomerates. |
4 | Gadam Volcano (Kwayar Kusar LGA, Borno State) | N10° 31′.951″ E011° 53′.485″ | 30,000 | Cone | 250 m | 479 m. asl | Olivine Basalt |
5 | Location 5 | N10° 32′.876″ E011° 57′.751″ | Inhabited | Plug | 683 m | Basaltic boulders/Agglomerates/tuff | |
6 | Location 6 | N10° 30′. 279″ E011° 50′ 726″ | Inhabited | Dome | 826 m | Vesicular Basaltic boulders/Agglomerates/tuff | |
7 | TUM | N10° 36′. 254′ E012° 06′ 564″ | 10,000 | Dome | 643 m asl | Scoraceous basalt with olivine/zeolite/Columnar basalt. | |
8 | Wakama (a) (BCG Village) | N10° 36′.472′ E012° 07′ 126″ | 2500 | Cone | 1 km | 677 m | Scoraceous basalt |
9 | Wakama (b) | N10° 37′.211′ E012° 08′ 886″ | 2500 | Caldera | 10 km | 701 m | Scoraceous basalt |
10 | Gwamya Volcano | N10° 33′.496″ E012° 06′. 341″ | 6000 | Cone | 500 m | 752 m | Scoraceous basalt/pyroclastic pile |
11 | Tilla Volcanic Hill | N10° 32′.549″ E012° 08′.477″ | 2500 | Cone | 500 m | 910 m | Scoraceous basalt/pyroclastic pile |
12 | Tilla Crater Lake | N10° 32′.336″ E012° 07′. 945″ | 10,000 | Caldera | 2 km | 751 m | Scoraceous basalt/pyroclastic pile |
13 | Versu Volcano | N10° 39′.759″ E012° 08′.457″ | 3000 | Seasonal Crater Lake | 700 m | 782 m asl | Olivine basalt |
14 | Dragna Volcano | N10°27′.132″ E012°05′.820″ | 5000 | Caldera filled up by collapsed materials. | 3 km | 750 m asl | Weathered scoraceous basa Basalt |
15 | Marama Volcano | N10°27′.746″ E012°09′.093″ | 150,000 | Cone | 1 km | 735 m | Scoraceous basalt/pyroclastics |
16 | Gwaram volcanic hill | N10° 39′.214″ E012° 08′.092″ | 8000 | Cone | 1 km | 942 m | Boulders of scoriaceous basalt |
17 | Batadeka (i) Volcanic hill | N10° 41′. 673″ E012° 07′.707″ | 3000 | Cone | 700 m | 884 m | Weathered scoriaceous basalt |
18 | Batadeka (ii) Volcanic hill | N10° 42′. 067″ E012° 07′.542″ | 3000 | Cone | 1 km | 1053 m asl | Weathered scoriaceous basalt |
19 | Kwatla Crater Lake | N10° 42′.117″ E012° 06′.433″ | Inhabited | Seasonal Crater Lake | 1.5 km | 752 m asl | Weathered scoriaceous basalt |
20 | Maldau | N10° 43′.500 E012° 06′.979″ | Inhabited | Cone | 350 m | 907 m asl | |
21 | Buratai Volcanic Hill | N10° 53′.926″ E012° 02′.800′ | 5000 | Dome | 700 m | 718 m asl | Weathered scoriaceous basalt/ pyroclastics |
22 | Kona Uku Volcanic hills | N10° 49′.814″ E012° 07′.062″ | 10,000 | 3 Cones clustered together | 2 km | 879 m asl | Weathered scoriaceous basalt/ pyroclastics |
23 | Dutsen Kura (Bogur) Volcanic hill | N10° 49′.313″ E012° 05′.978″ | 5000 | Seasonal Crater Lake | 1.2 km | 1011 m asl | Weathered scoriaceous basalt/ pyroclastics |
24 | Kukuwa (Gabai lga Yobe State) | N11° 06′.387″ E011° 53′.689″ | 5000 | Plug | 200 m | 429 m asl | Columnar basalt |
25 | Kukuwa II | N11° 06′. 443″ E011° 53′. 534″ | 5000 | Several Plugs | 200 m | 435 m asl | Columnar basalt |
26 | Kurara Volcanic Hill(Garkida junction Adamawa State) | N10° 22′.460″ E012° 34′.284″ | 50,000 | Cone | 1 km | 661 m asl | Weathered scoriaceous basalt/pyroclastics |
27 | Song (Song-Gombi Road) | N9° 51′.036″ E012° 36′.383″ | 50,000 | Cone | 700 m | 477 m | Weathered scoriaceous basalt/pyroclastics |
28 | Song (Hawul Mountains) | N9° 49′.504″ E012° 37′.155″ | 10,000 | 4 different cones aligned N-S | 250 m each | 420-1000 m asl | Weathered scoriaceous basalt/pyroclastics |
Inventory of the volcanoes of the Biu Plateau, Nigeria.
The Kerang twin volcanoes are located at Kerang town and its environs in the present Mangu Local Government Area, about 120 km from Jos, Plateau State (Figure 1). The Kerang I (Dustin) volcano has a peak of 1456 m above sea level and a crater diameter of 300 m. The volcanic pile consists of ash, lapilli, scoria, pumices, breccias, basalts, boulders, and pyroclastic materials of various sizes. The Kerang II (Kerang) volcano has three craters with a peak height of 1510 m above sea level with a crater diameter ranging from 600 m to 1 km (Table 1). This volcano (Kerang II) is the second largest volcano on the Jos Plateau compared to the Jiblik volcano which has a peak height of 1670 m above sea level. The volcanic pile of the Kerang II volcano is composed of ash, lapilli, scoria, breccias, bombs, basaltic boulders and pyroclastic materials (lapilli, granitic and lava flows).
The Pidong volcano (Maar) has a series of three craters and aligned along the general North-South trend of the Panyam Volcanic Line [10]. The Pidong Maar consists of a sequence of pyroclastic materials (mixture of large fragments of basement rocks/pyroclastics, scoria and ash) and indicative of violent eruption [9]. The Gu volcanic line consist of five volcanoes from NW to SW namely Jiblik, Kagu, Katul and Lagdak volcanoes. The volcanic cones are composed essentially of volcanic ash, lapilli, bombs, tuff agglomerates, basalts and scoria. Most of them occur as single cinder cones (like at Miango, Wushik, Kerang Swan junction, etc.) but rarely as clusters of two or more volcanoes (for example Jiblik, Kassa, Kerang twin volcanoes, Pidong, etc.)
Also, the relatively large sizes of some of these volcanoes (Miango, Kassa, Jiblik, Kerang, etc.) suggest that quite a large volume of ejecta materials were spewed out covering quite a large landmass (valleys and low-lying plains) as lava flows. Lava flows apparently from the Jiblik volcanic can be traces to several kilometers south of the Jos Plateau escarpment. If any of these volcanoes erupt today with the same intensity and volume presumed, a large expanse of land would be buried and about 2 million people living around these volcanoes are potentially at risk.
The volcanoes of the Biu Plateau (Table 2) present similar physical and petrographic characteristics as those of the Jos Plateau region. The volcanoes also form near linear alignments from the north to the south and extend right through the low-lying Basement complex into the sedimentary formations of the Benue valley (Garkida-Gombi-Song areas in Adamawa State). The volcanoes are simple and never in clusters, but with very large craters of greater than 1 km, (Caldera). The volcanoes extruded directly the basement rocks and therefore are of lower altitude above sea level relative to those of the Jos Plateau, which extruded the already high-level Younger Granite bodies.
Also, unlike the volcanoes of the Jos Plateau, those of Biu Plateau are constituted by a large volume of volcanic ash and pyroclastic materials (for example, at Gwamya, Tilla Crater Lake, Gadam, Batadeka, Buratai, Katla volcanoes, etc.) (Table 2), suggesting that there was a tremendous spewing of ejecta materials (ashes and gases) into the atmosphere prior to the violent eruptions and/or in-between the eruptions.
The major and trace elements geochemical compositions of the basaltic rock samples collected from the various volcanic cones in the Jos Plateau volcanic province are presented in Tables 3 and 4. The volcanic cones situated at the northern end of the volcanic line here referred to as the north-western group are represented by Miango (M1 & M2) and Kassa (K1–5), while the south-eastern end group are represented by Jiblik (G1 &G2), Tingyaras (S1), Ampang (S2), Pidong (S3), Wulshik (S4), Kugol (S5) and Kerang (S6).
Analyte symbol unit | SiO2 (%) | Al2O3 (%) | Fe2O3 (%) | MnO (%) | MgO (%) | CaO (%) | Na2O (%) | K2O (%) | TiO2 (%) | P2O5 (%) | LOI (%) | Total (%) | Al2O3/ TiO2 | CaO/ TiO2 | Al2O3/ CaO |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
M1 | 44.84 | 15.02 | 12.33 | 0.166 | 8.50 | 8.86 | 4.09 | 1.88 | 2.668 | 0.76 | <0.01 | 98.83 | 5.63 | 3.32 | 1.70 |
M2 | 43.80 | 15.01 | 12.61 | 0.166 | 8.54 | 8.32 | 3.40 | 1.87 | 2.727 | 0.74 | 1.5 | 98.68 | 5.50 | 3.05 | 1.80 |
G1 | 49.69 | 14.90 | 9.83 | 0.142 | 8.10 | 7.07 | 3.34 | 1.70 | 1.659 | 0.47 | 1.33 | 98.81 | 9.03 | 4.26 | 2.11 |
G2 | 64.21 | 14.74 | 5.60 | 0.087 | 2.37 | 3.91 | 3.29 | 3.54 | 1.124 | 0.43 | 0.96 | 100.3 | 13.11 | 3.48 | 3.77 |
S1 | 44.97 | 12.41 | 11.51 | 0.166 | 12.85 | 9.43 | 3.13 | 1.62 | 2.213 | 0.59 | 0.03 | 98.92 | 5.61 | 4.26 | 1.32 |
S2 | 44.77 | 12.48 | 11.34 | 0.165 | 12.74 | 9.39 | 2.96 | 1.50 | 2.194 | 0.57 | 0.47 | 98.58 | 5.69 | 4.28 | 1.33 |
S3 | 45.75 | 16.00 | 11.92 | 0.161 | 6.34 | 8.16 | 3.58 | 2.21 | 2.849 | 0.70 | 0.99 | 98.66 | 6.62 | 2.86 | 1.96 |
K1 | 46.99 | 13.99 | 11.36 | 0.630 | 8.36 | 9.47 | 3.74 | 1.53 | 2.176 | 0.60 | 0.52 | 98.95 | 6.43 | 4.35 | 1.48 |
K2 | 50.06 | 14.23 | 10.83 | 0.149 | 7.16 | 8.9 | 3.50 | 1.22 | 2.158 | 0.37 | <0.01 | 98.57 | 6.59 | 4.12 | 1.60 |
K3 | 48.02 | 18.07 | 10.42 | 0.164 | 3.30 | 7.74 | 5.28 | 2.80 | 2.516 | 0.84 | 0.12 | 99.27 | 7.18 | 3.08 | 2.33 |
K4 | 47.49 | 14.17 | 11.35 | 0.167 | 7.81 | 9.29 | 3.82 | 1.58 | 2.211 | 0.64 | 0.20 | 98.74 | 6.41 | 4.20 | 1.53 |
K5 | 47.05 | 13.87 | 11.28 | 0.160 | 8.17 | 9.36 | 3.55 | 1.59 | 2.17 | 0.64 | 0.67 | 98.52 | 6.39 | 4.31 | 1.48 |
S4 | 45.26 | 13.52 | 11.34 | 0.162 | 10.71 | 9.47 | 3.28 | 1.70 | 2.397 | 0.62 | 0.32 | 98.78 | 5.64 | 3.95 | 1.43 |
S5 | 44.77 | 12.82 | 11.40 | 0.166 | 11.50 | 9.58 | 2.83 | 1.65 | 2.318 | 0.61 | 1.08 | 98.73 | 5.53 | 4.13 | 1.34 |
S6 | 46.27 | 13.02 | 11.25 | 0.163 | 11.24 | 9.21 | 3.51 | 1.69 | 2.262 | 0.69 | 0.23 | 99.35 | 5.76 | 4.07 | 1.41 |
Major element compositions (in weight percentage) of volcanic rocks from the Jos Plateau Volcanic Province.
Analyte symbol unit | Ba ppm | SR ppm | Y ppm | Sc ppm | Zr ppm | Be ppm | V ppm | Ba/Sr | Zr/Y |
---|---|---|---|---|---|---|---|---|---|
M1 | 619 | 840 | 25 | 19 | 234 | 2 | 161 | 0.74 | 9.36 |
M2 | 865 | 799 | 26 | 19 | 239 | 2 | 153 | 1.08 | 9.19 |
G1 | 518 | 637 | 18 | 15 | 205 | 2 | 122 | 0.81 | 11.39 |
G2 | 1215 | 723 | 26 | 12 | 328 | 3 | 121 | 1.68 | 12.62 |
S1 | 530 | 654 | 22 | 23 | 193 | 2 | 185 | 0.81 | 8.77 |
S2 | 554 | 646 | 21 | 22 | 190 | 2 | 178 | 0.86 | 9.05 |
S3 | 794 | 1098 | 24 | 15 | 228 | 2 | 174 | 0.72 | 12.00 |
K1 | 571 | 782 | 25 | 18 | 177 | 2 | 161 | 0.73 | 7.08 |
K2 | 551 | 460 | 43 | 20 | 155 | 2 | 171 | 1.20 | 3.06 |
K3 | 820 | 983 | 26 | 7 | 258 | 3 | 155 | 0.83 | 9.92 |
K4 | 672 | 758 | 38 | 19 | 176 | 2 | 164 | 0.89 | 4.63 |
K5 | 523 | 1095 | 24 | 18 | 177 | 2 | 157 | 0.48 | 7.36 |
S4 | 569 | 748 | 23 | 21 | 212 | 2 | 178 | 0.76 | 9.22 |
S5 | 585 | 697 | 23 | 23 | 204 | 2 | 180 | 0.84 | 8.84 |
S6 | 688 | 766 | 23 | 20 | 215 | 2 | 172 | 0.90 | 9.35 |
Trace elements compositions (in ppm) of the basaltic rocks from the Jos Plateau Volcanic Province.
Southeastern volcanoes: G1—basalt of Jiblik volcano; S1—basalt of Timjagha’as volcano; S2—basalt of Ampang volcano; S3—basalt of Pidong volcano; S4—basalt of Wushik volcano; S5—basalt of Kogul volcano; S6—basalt of Kerang volcano.
Northwestern volcanoes: M1—basalt of Miango North volcano; M2—basalt of Miango South volcano; K1—basalt of Kassa volcano; K2—basalt of Kassa volcano; K3—basalt of Kassa volcano; K4—basalt of Kassa volcano; K5—basalt of Kassa volcano.
Period | pH | Temperature (°C) | EC (μs/m) | Mg (mg/l) | Ca (mg/l) | Na (mg/l) | K (mg/l) | Zn (mg/l) | Fe (mg/l) | Cu (mg/l) | Al (mg/l) | SO4 (mg/l) | Cl (mg/l) | Alkalinity (CaCO3) (mg/l) | F (mg/l) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patterson (1986) report | 9.35 | 28.5 | 410 | 36.4 | 13.65 | 12.8 | 25.8 | 0.065 | 0.27 | <0.004 | — | <0.33 | 2.5 | 335 | — |
Present study (2013–2015) | 7.17 | 26.1 | 299 | 29.68 | 39.67 | 6.89 | 11.39 | 0.064 | 0.612 | 0.0039 | 0.456 | 1.03 | 5.67 | 141.5 | 0.249 |
Comparative hydrogeochemical data of 1986 and the present study.
The rocks display similar SiO2 wt% contents (44.84–50.06 wt%) for the north-western group of volcanoes (M1&2 and K1–5) and 45.26–46.25 wt% for S1–6 and 49.69 wt% for the Jiblik volcano (G1). However, the sample G2 from Jiblik with high SiO2 content of 64.21 wt% is exceptionally acidic and does not seem to be a basalt. Many of the rocks from the Kassa volcanoes (K1, K3, K4, and K5) display the highest SiO2 content (46.99–50.06 wt%) as opposed to those from Miango volcanoes (M1 &M2) and the southern volcanoes (S1–6) whose SiO2 contents are typical of a normal basalt (45.26–46.25 wt%).The Miango and the Kassa volcanoes display higher Fe2O3 contents (12.33–12.61 and 10.42–11.35 wt% respectively). The southern group (G1 & S1–6) displays lower Fe2O3 content; 9.83 wt% for the Jiblik volcano (G1); and a relatively higher but similar concentrations of between 11.25 and 11.92 wt% for the Panyam Volcanic line members (S1–6).
In general, the Al2O3 contents of all the basalts from the different volcanic cones are significantly high but vary narrowly inter/intra the volcanic cones (13.87–18.07 wt% for the north-western group and 12.41–18.07 wt% for the southern group (G1 & S1–6)). In terms of the MgO content, the southern group (S1–6) presents relatively higher values of between 10.71 and 12.58 wt% as against an average of 8.00 wt% for the northern group (M1–2 & K1–5). The CaO, Na2O, K2O and TiO2 contents for all the volcanoes vary narrowly; averagely 8; 3; 1.5 and 2 wt%, respectively.
Their Al2O3/TiO2 ratios vary narrowly and could be on that basis be subdivided into two groups; those with ratios between 5.53 and 5.69 and then those between 6.39 and 6.62 for the entire volcanic line (N-S) (Figure 3). This is further a reflection of the variations in Al2O3 contents of the basalts since TiO2 contents remain relatively constant. Similarly, their CaO/TiO2 and Al2O3/CaO ratios vary from 2.6 to 4.31 and 1.34–1.60 respectively. Such narrow difference in these ratios is expected from a low degree of magmatic differentiation of the same parent material by partial melting process (Figures 3 and 4).
Plot of SiO2 versus Al2O3/TiO2 ratios.
Plot of SiO2 versus Al2O3/CaO ratios.
Similarly, the rocks present subtle variations in incompatible element ratios Ba/Sr. and Zr/Y (0.73–0.90 and 8.77–9.35, respectively); all supportive of their subjection to low degree of magmatic differentiation and/or similar source.
In the SiO2 versus MgO wt% plot, the southern volcanoes overwhelmingly display higher MgO contents as opposed to the lower values for the northern group of volcanoes (Figure 5c). It is expected that the Kassa volcanoes (K1–5) which are more differentiated (by their higher SiO2 contents) than the others to present lower MgO contents but instead display similar MgO contents. This scenario is true of their Fe2O3 contents. However, there is a weak negative correlation between Fe2O3, MgO, TiO2 and MnO versus silica indicating a progressive decrease of these oxides with differentiation (Miango-Southern group-Kassa) corresponding to compositional variations related to the removal of different proportions of olivine/pyroxenes from the melt as it becomes more felsic (Figure 6a–d).
(a–f) Plots of SiO2 versus major oxides of the volcanic rocks of the Jos Plateau Volcanic Province.
province.
(a–d) Plots of SiO2 versus major oxides of the volcanic rocks of the Jos Plateau Volcanic Province.
The Kassa volcanoes in the northern group and those of the southern group exhibit higher CaO contents compared to lower CaO values at Miango (M1&M2) and also of the northern group. The observed high CaO content suggest the recrystallization of clinopyroxenes in the early stages of crystallization. In general, there is a positive correlation depicting a progressive increase of CaO with differentiation from Miango to the southern group to Kassa (Figure 5a–f). This increase is not visible at the level of one volcano but several of them put together. The high Fe2O3, MgO and CaO could be as a result of the bulk crystallization of olivine, pyroxene and plagioclase during the early stages of differentiation. The progressive increase in the contents of Al2O3 corresponds with the increase in the alkaline metals content (Na2O + K2O) suggesting the crystallization of plagioclase with increased degree of differentiation. The alkaline oxides (Na2O + K2O) are correspondingly highest in the most differentiated rocks (K1–5) (Figure 6d). In a silica versus total alkali diagram (Figure 7), the rocks fall within the alkaline field and are therefore classified as predominantly alkaline basalts. Only a few rocks fall in the sub-alkaline field which could be of tholeiitic character (high silica and Fe Contents). Furthermore, in a log (Zr/TiO2) versus SiO2 diagram (Figure 8), the bulk of the rocks fall in the alkaline field reaffirming their alkaline nature (Figure 9).
Silica versus Total Alkali diagram [
Plot of Log (Zr/TiO2) ratio versus SiO2 [
SiO2 versus Na2O + K2O classification diagram of basalts of the Jos Plateau volcanoes [
In respect to their Mg#, it varies very narrowly within the individual volcano signifying a subtle degree of differentiation (partial melting) and thus reflecting a low degree of magmatic differentiation and the consequent subtle compositional variations observed. However, for the entire volcanoes put together, the Mg# vary significantly from 27 to 56 suggesting formation of the rocks by fractional crystallization at larger scale. The southern volcanoes (S1–6) have the highest Mg# relative to those of the northern group (K1–5 and M1 & M2) (Figure 10a–d). When the rocks are plotted in Mg# versus Fe2O3 diagram (Figure 10b), a positive correlation is obtained indicating a progressive decrease in Fe2O3 with increasing degree of magmatic differentiation. The relatively similar Ba/Sr. and Zr/Y ratios for these rocks but with progressive decrease in Mg# lends credence to their derivation from the same magma reservoir by differentiation. It appears that the rocks with the highest Mg# (samples S1–6) present compositions that are close to that of the parent materials since the magma did not suffer high degree of differentiation giving rise to a variety of rocks. The subtle variation of Mg# and the incompatible element ratios highlighted above are supportive of the derivation of these basalts by partial melting process of a magma from the same source.
(a–d) Plot of some selected major oxides versus Mg# for the volcanic rocks of the Jos Plateau volcanic province.
The geochemical data plotted in the ternary diagram of Ti/100-Zr-Y*3 [12] show clearly that they were majorly emplaced within the continental crust (Figures 11 and 12). This fact distinct these basalts from those of the Island arc and the Mid Oceanic Ridge.
Log Zr (ppm) versus Log (Zr/Y) (ppm) diagram [
Ternary diagram of Ti/100 – Zr – Y*3 [
The incompatible elements when plotted in a spidergraph normalized to Chondrites in comparison with OIB (Figure 13) display a relatively similar pattern with slight enrichment in their incompatible elements. These characteristic features are typical of most alkali basaltic suites derived from a deeper mantle source akin to that of the OIB [12, 14, 16, 17, 18, 19].
Spidergraph plot of incompatible element compositions of basaltic rocks from the Plateau volcanoes normalized to OIB [
A sample by sample result is presented in Table 5. The Ar/Ar ages span between 1.3 and 2.5 Ma, confirm the earlier K-Ar ages of 2.1 and 1.9 ± 0.31 Ma reported by [1] on dolerites on the Jos Plateau. The short interval in the radiometric ages suggests volcanic eruptions occurred at discrete times, separated by short periods of non-activity at a mean age average of 0.55 Ma (CN3 = 2.500 ± 0.318 Ma and CN5 = 1.970 ± 0.173 Ma). This long period must have been dominated by profound erosion. The considerable long-time difference from the oldest to the youngest eruption suggests that there was relatively steady magma source overtime.
Comparative hydrogeochemical parameters of previous study [7] and this present study is presented in Table 5. It shows clearly that pH and alkalinity have decreased overtime from 9.35 to ≥7.0 and from 335 to 145 mg/l, respectively as well as increase in the concentrations of Cl from 2.5 to 5.6 mg/l; SO4 from <0.33 to 1.05 mg/l (Table 5).
In general, the major element concentrations in the Pidong Lake decrease in the order Mg > Ca > K > Na (Table 5). The highest concentrations of Mg (30 to ≤40 mg/l), Ca (21–25 mg/l), K (15 mg/l) Na (8–11 mg/l) are observed during the dry season (January–April) while lowest concentrations of Mg (16–25 mg/l), Ca (10–15 mg/l), K (4–7 mg/l) in the rainy season (August–October). The intermittent change of color of the Lake from clear blue to brown has been attributed to the increase in Fe concentrations into the Lake.
Figure 14 presents the REE patterns from the Crater Lake normalized to Chondrites. The REE concentrations are impoverished relative to Chondrite values (<1 × Chondrite). There are significant variations in the LREE (0.03–0.18 × Chondrite for La) relative to HREE (Gd-Lu). An important characteristic of the spectra is the similarities between the LREE patterns indicating similar source. The slight enrichment in LREE must have been influenced by fluid percolation through the host crustal materials (host granite basement) rich in these elements.
Spidergraph of rare earth elements (REEs) of Pidong Lake normalized to Chondrite [
The major anion concentrations from the lake vary in concentrations in the order of -HCO3 > Cl > SO4. The highest concentration of in the LREE range from <0.5 to 5.5 mg/l and 0.0675 to 0.0321 mg/l, respectively, and were observed during the dry season (October–April). The concentrations of HCO3, Cl and F could have been influenced by interacting percolating water and host rock chemistry.
The increase in the concentrations of SO42−, Cl− (<0.33–1.03 and 2.5–5. 67 mg/l, respectively) as well as the decrease in Alkalinity and pH from 335 to 141.5 mg/l and 9.35 to ≈7.00, respectively. These variations in concentrations suggest a possible input of magmatic/fumaroles percolating upwards to shallow groundwater aquifers coming in contact with meteoric water.
The oxygen and hydrogen isotope composition and plot of ∂ 18O and ∂ 2H relative to SMOW line shows that the Pidong Crater Lake is of meteoric origin.
This work presents and affirms the existence of relicts of past volcanic eruptions (dormant volcanoes) in Nigeria (Jos and Biu Plateaux).
That these volcanic edifices were previous eruption sites suggest they are potential eruption sites. The proximity of these volcanic edifices to those of the Cameroon volcanic line, which has witnessed a series of volcanic activity, is worrisome.
The mafic lavas in both the Jos and the Biu Plateaux volcanic provinces display geochemical compositions that are characteristic of alkaline basalts
Petrologically, the basaltic rocks display compositions varying from basalt proper to basanite-tephrite-hawaiite, emplaced within the host crustal rocks (Basement rocks).
The chain of volcanoes evolved from the same basalt parent magma by crystal fractionation each cluster derived by partial melting of the same residual parent magma.
Recent 40Ar/39Ar dating of basalts from overlapping volcanic cones from the Jos Plateau province (ranging from 2.5 to 1.34 Ma) confirms the Quaternary age (Pleistocene epoch) of emplacement for these volcanoes and the intermittency of eruptions inter and intra the volcanic line in the provinces.
That these volcanic edifices were previous eruption sites suggest they are potential eruption sites. The proximity of these volcanic edifices to those of the Cameroon volcanic line, which has witnessed a series of volcanic activity, is worrisome. The volcanic eruption of Mount Vesuvius in Italy in the year 2004 known to have been dormant since 24 AD is a clarion call. Furthermore, the recent volcanic eruption in Iceland April 15, 2010 after 200 years of silence should increase the worry. All these information calls for further comprehensive work on these dormant volcanoes for risk assessment.
The minor intermittent fumarolic activities observed within the Pidong Crater Lake marked by the change in the water color from the normal bluish to brown-red color, (due to Fe-input) call for more comprehensive investigation of the volcano and further strengthen the idea of the possibility of the volcano roaring back to life.
This study is an on-going project on volcanoes in Nigeria, being embarked upon by three PhD scholars. It is being supported by STEP-B World Bank funding. Also, the Centre for Geodesy and Geodynamics, National Space Research and Development Agency (NASRDA) is well appreciated for providing funds for the field work.
We declare that there are no “conflict of interest.”
The authors are deeply indebted to the Geological Survey of Norway for dating the rocks. We express our deep thanks to anonymous reviewers of this manuscript, who have provided constructive criticisms which has improved the quality of the initial manuscript. Our profound gratitude goes to our project students who assisted in the sample collection.
alkali basalt above sea level million (106) years mid-ocean ridge basalt National Space Research and Development Agency ocean island basalt parts per billion (1/109) parts per million (1/106) standard mean ocean water inductively coupled plasma optical emission spectrometry stable isotope ratio expressed relative to a standard
Glycosylation is a critical process to maturate the glycoproteins and glycolipids. Many factors were demonstrated to regulate this process, including 1) nucleotide sugar donors, 2) glycosyltransferase enzymes, and 3) glycosidase enzymes. The activated nucleotide sugars, synthesized through the hexosamine biosynthesis pathway, are served as sugar donors for the glycosylation process. More than 200 glycosyltransferase (GT) and glycosidase (GA) enzymes, residing in the endoplasmic reticulum (ER) or Golgi apparatus, are responsible for the addition and removal of sugar onto the glycoconjugates [1]. There are two major types of protein core-glycosylation, including N-linked and O-linked glycosylation (Figure 1). Both N-linked and O-linked glycans are generally terminal-modified with sialic acid and fucose
Protein glycosylation. After transcription and translation, the proteins undergo N-linked glycosylation in endoplasmic reticulum or O-linked glycosylation in Golgi apparatus. Both N-linked glycans and O-linked glycans undergo peripheral modifications, fucosylation, and sialylation in the Golgi apparatus.
Recent evidence suggests the alteration of glycosylation in glioblastoma (GBM) [3, 4, 6, 7]. GBM-associated glycans and glycoconjugates, such as the cluster of differentiation 44 (CD44), CD133, and ephrin-A1, were discovered to play important roles in tumor progression, leading to the poor prognosis of patients [8, 9]. Defects of glycosylation in GBM tumors were found in glycoproteins, glycolipids, glycosaminoglycans, or proteoglycans. The alteration of protein glycosylation occurred in both N-linked and O-linked glycosylation. Besides, aberrant terminal glycan modification of sialylation or fucosylation was also observed in GBM [3]. Moreover, the glycans and glycosylation also exhibited the functional significance in glioma stem-like cells (GSC) by regulating the stem cell-related phenotypes [10, 11].
Not only in cancer cells, the tumor microenvironment (TME) was also presented with aberrant glycosylation [12, 13]. Glycosylation changes in TME were found to promote tumor progression, immunosuppression, and therapeutic resistance [14]. Therefore, it is proposed that glycosylation changes of TME might be an alternative target for the treatment of GBM.
This chapter collectively summarizes the recent information on glycan and glycosylation changes and their roles in GBM progression and therapeutic resistance. The information provided here may fulfill our understanding of the roles of glycosylation and its potential to be a target for the treatment of GBM.
The N-linked glycosylation transfers the oligosaccharide chain to the target polypeptide by forming the linkage between the
MGAT-1 | Hybrid N-linked oligosaccharide |
| [15] |
MGAT-5 | Biantennary or β1,6-GlcNAc-containing |
| [16, 17, 18] |
B4GalT-5 | Highly branched N-glycans |
| [19, 20, 21] |
B3GnT-8 | Polylactosamine on branched N-glycans |
| [22] |
GALNT-2 | O-GalNAc glycan |
| [23] |
GALNT-12 | O-GalNAc glycan |
| [24] |
FUT-8 | α1,6-fucosylated N-glycan |
| [25] |
ST3Gal-3 | α2,3-sialylated glycan |
| [18] |
Glycosyltransferases involved in the progression of GBM.
β1,3-N-acetylglucosaminyltransferase-8, B3GnT8; β1,4-Galactosyltransferase 5, B4GalT5; mannosylglycoprotein β-
An increase of bi-, tri-, and tetra-anternary N-linked glycans was found to be associated with the progression of GBM [15, 16, 17, 26]. The α1,6-mannosylglycoprotein-β-
A new subclass of
Another N-link-associated enzyme, a β1,3-
Inhibition of N-glycan synthesis by the specific siRNA or inhibitors significantly suppresses tumor growth, metastasis, and radioresistance of GBM [15, 16, 17, 18, 29, 30, 31]. This information suggested the potential of N-glycosylation to be a target for the treatment of GBM.
Golgi-resident glycosyltransferases are responsible for the synthesis of O-glycans
In GBM, the alteration of O-linked glycosylation played a significant role in the tumor progression and therapeutic resistance [23, 24]. The significance of GALNT enzymes in the progression of GBM has been revealed, suggesting their possibility of being a new target for GBM treatment (Table 1). GALNT-2 was demonstrated to promote the migration and invasion of cancer cells [23]. Expression of GALNT-12 was associated with poor prognosis of GBM patients as it promotes cancer cell proliferation, migration, and invasion
α2,3-sialylation | ST3Gal-1, ST3Gal-2, ST3Gal-3, ST3Gal-4, ST3Gal-5, ST3Gal-6 | Sia-α2,3-Gal |
α2,6-sialylation | ST6Gal-1 and ST6Gal-2 | Sia-α2,6-Gal |
ST6GalNAc-1, ST6GalNAc-2, ST6GalNAc-3, ST6GalNAc-4, ST6GalNAc-5, and ST6GalNAc-6 | Sia-α2,6-GalNAc | |
α2,8-sialylation | ST8Sia1, ST8Sia2, ST8Sia3, ST8Sia4, ST8Sia5, and ST8Sia6 | Sia-α2,8-Sia |
Sialylation and the associated enzymes and glycan structures.
Sialyltransferase, ST; Galactose, Gal;
The terminal glycan modification by fucose, called “Fucosylation,” is controlled by the fucosyltransferase (FUT) enzymes. In human, 13 FUTs are classified according to their activities into 1) α1,2-FUTs (FUT-1 and FUT-2), 2) α1,3-FUTs (FUT-3, FUT-4, FUT-5, FUT-6, FUT-7, FUT-9, FUT-10, and FUT-11), 3) α1,4-FUTs (FUT-3 and FUT-5), 4) α1,6-FUTs (FUT-8), and 5) O-FUTs (Pofut-1 and Pofut-2) [34]. Altered expression of FUTs and the fucosylated-glycans were found to associate with tumor development and progression [5, 35]. In GBM, the aggressiveness and malignant phenotypes GBM were associated with fucosylated Lewis antigens’ expression [36]. The enzyme FUT-8, responsible for α-1,6-fucosylation of N-glycans, was discovered to promote the growth, migration, and invasion of GBM cells [25]. Inhibition of fucosylation by the inhibitor-2F-peracetyl-fucose could sensitize the effect of temozolomide (TMZ), suggesting the potential of FUT-8 to be a target for GBM treatment [25].
Sialylation is a modification of glycoproteins and glycolipids by sialic acid (Sia). There are 20 sialyltransferase enzymes (STs) responsible for three types of sialylations: 1) α2,3-sialylation, 2) α2,6-sialylation, and 3) α2,8-sialylation (Table 2) [37, 38].
Sialylation was demonstrated to involve in the stemness maintenance of GSC and tumor progression, suggesting its possibility to be a promising target for the treatment of GBM [39, 40]. An α-2,3 sialylation was found to promote the progression, while α-2,6 sialylation suppresses the GBM. Inhibition of α-2,3 or enhancement of α-2,6 sialylation significantly suppresses the metastatic ability of GBM cells [41, 42, 43]. Using lectin from
In addition, sialidases or neuraminidases (NEU), the enzymes that remove terminal Sia from the oligosaccharide chain of glycoproteins and glycolipids, were also altered in GBM. The overexpression of NEU3 significantly suppresses cancer cells’ migration and invasion ability by promoting focal adhesions through calpain-dependent proteolysis [44]. NEU4 was found to be upregulated in GSC, and suppression of NEU4 significantly reduces cell survival and stemness properties of the cells [45].
Altered syntheses of gangliosides, glycosaminoglycans, and proteoglycans were observed to play significant roles in GBM [46, 47, 48, 49, 50, 51, 52]. The GD3-gangliosides, heparan sulfate (HS) glycosaminoglycans, and their responsible enzymes were found to be altered in GBM and proposed as a potential GBM marker [46, 47, 48]. Glycosaminoglycans played essential roles in the communication between GBM cells and their TME. Alteration of HS synthesis by ablation of heparanase (HPSE) results in the significant reduction of tumor cell adhesion and invasion [48]. This information implied that HS is an important factor in promoting GBM invasion; it is therefore possibly proposed as a therapeutic target for GBM.
Alteration of proteoglycan synthesis was found to associate with the development and progression of GBM [49, 50, 51, 52]. Expression of tumor-associated proteoglycans and their related enzymes were found to facilitate the tyrosine kinase signaling pathway, which benefits the progression of GBM, suggesting their potential as a promising prognostic marker and target for GBM treatment [49]. The elevation of neuro-glial proteoglycan-NG2 was associated with the invasiveness of GBM [50]. NG2 was found to control the vascular morphology and functions, suggesting its role in facilitating metastasis
Alteration of glycosylation was predominantly observed in either cancer cells or TME in GBM. Both core-glycosylation and peripheral glycan modifications were important factors in regulating the tumor development, progression, and therapeutic resistance. Several strategies have been proposed to target glycans and glycosylation for the treatment of GBM.
Suppression of glycosylation using specific interferences or inhibitors is a potential strategy to target glycosylation [54, 55]. However, there is a limitation to using the broad-spectrum glycosylation inhibitors for cancer treatment as they also affect the neighboring non-tumor cells. Targeting glycosylation of a particular glycoprotein or glycoconjugate is a possible strategy for cancer treatment. In GBM, interference of hyaluronic acid synthesis by methylumbelliferone (4-MU), an inhibitor of hyaluronic acid synthase capable of crossing the blood-brain barrier (BBB), was found to significantly inhibit the proliferation of GBM [56].
The short peptide is recently applicable for targeting or suppressing the specific glycoform of a particular glycoprotein in cancer cells. The deglycosylated form of brevican (dg-Bcan), an ECM-associated glycoprotein upregulated in GBM, was explicitly bound by a small 8-amino acid dg-Bcan-Targeting Peptide (BTP). The radiolabeled-BTP could be internalized into the cancer cell, suggesting its potential to be used as an imaging agent to detect GBM [57]. Further studies to apply this peptide for the treatment of GBM by conjugating it with chemo-drugs or other substances are noteworthy.
Based on the sugar preferential of lectins, the plant lectins were widely used to determine the expression of GBM-associated glycans as well as the functional analyses either
DBA | GalNAc-modified glycan |
| [11] | |
---|---|---|---|---|
GSL-I | βGal/GalNAc |
| [58] | |
LCA | Core-fucosylated biantennary N-glycans |
| [26] | |
MAL-II | α-2,3 sialylated glycans |
| [39] | |
E-PHA | Bisecting β1,4-GlcNAc N-glycans |
| [18, 59, 60] | |
RCA-I | Highly branched N-glycans |
| [19, 21] |
Lectins used in GBM studies.
The
In conclusion, glycans and glycosylation have been identified to play significant roles in GBM progression and therapeutic resistance. Targeting glycans and glycosylation is possibly an alternative strategy for the treatment of GBM; however, further studies to target specific glycosylation of a particular glycoconjugate are still needed. In addition, the clinical studies or trials on the potential of using glycans and glycosylation as a target for GBM treatment are still a large gap that needs to be further evaluated.
The author would like to thank the supports from the National Research Council of Thailand and Khon Kaen University, Thailand.
The author declares no conflict of interest.
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landscape from the natural ones by exploiting a combination of amplitude and phase changes in satellite radar images. At a first step, ERS and Envisat data stacks are processed using COS software developed by the company SARMAP. Various features related to amplitude and phase as well as to their changes are then extracted from images of the same sensor. Combinations of the features extracted from one image, from several images of one sensor as well as from different sensors are performed to derive robust indicators of potential human-related changes. Finally, possibilities of exploiting and integrating other types of information sources such as various reports, maps, historical or agricultural data, etc. in the combination process are analyzed to improve the obtained results. The outcomes are used to evaluate the potential of this method applied to Sentinel-1 images.",book:{id:"4818",slug:"mine-action-the-research-experience-of-the-royal-military-academy-of-belgium",title:"Mine Action",fullTitle:"Mine Action - The Research Experience of the Royal Military Academy of Belgium"},signatures:"Damien Closson and Nada Milisavljevic",authors:[{id:"13897",title:"Dr.",name:"Damien",middleName:null,surname:"Closson",slug:"damien-closson",fullName:"Damien Closson"}]},{id:"55272",doi:"10.5772/67007",title:"Ground‐Penetrating Radar for Close‐in Mine Detection",slug:"ground-penetrating-radar-for-close-in-mine-detection",totalDownloads:2890,totalCrossrefCites:3,totalDimensionsCites:5,abstract:"In this chapter, two of the major challenges in the application of ground‐penetrating radar in humanitarian demining operations are addressed: (i) development and testing of affordable and practical ground penetrating radar (GPR)‐based systems, which can be used off‐ground and (ii) development of robust signal processing techniques for landmines detection and identification. Different approaches developed at the Royal Military Academy in order to demonstrate the possibility of enhancing close‐range landmine detection and identification using ground‐penetrating radar under laboratory and outdoor conditions are summarized here. Data acquired using different affordable and practical GPR‐based systems are used to validate a number of promising developments in signal processing techniques for target detection and identification. The proposed approaches have been validated with success in laboratory and outdoor conditions and for different scenarios, including antipersonnel, low‐metal content landmines, improvised explosive devices and real mine‐affected soils.",book:{id:"4818",slug:"mine-action-the-research-experience-of-the-royal-military-academy-of-belgium",title:"Mine Action",fullTitle:"Mine Action - The Research Experience of the Royal Military Academy of Belgium"},signatures:"Olga Lucia Lopera Tellez and Bart Scheers",authors:[{id:"176830",title:"Dr.",name:"Olga",middleName:"Lucia",surname:"Lopera Tellez",slug:"olga-lopera-tellez",fullName:"Olga Lopera Tellez"}]},{id:"55000",doi:"10.5772/66691",title:"Remote Sensing for Non‐Technical Survey",slug:"remote-sensing-for-non-technical-survey",totalDownloads:1550,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"This chapter describes the research activities of the Royal Military Academy on remote sensing applied to mine action. Remote sensing can be used to detect specific features that could lead to the suspicion of the presence, or absence, of mines. Work on the automatic detection of trenches and craters is presented here. Land cover can be extracted and is quite useful to help mine action. We present here a classification method based on Gabor filters. The relief of a region helps analysts to understand where mines could have been laid. Methods to be a digital terrain model from a digital surface model are explained. The special case of multi‐spectral classification is also addressed in this chapter. Discussion about data fusion is also given. Hyper‐spectral data are also addressed with a change detection method. Synthetic aperture radar data and its fusion with optical data have been studied. Radar interferometry and polarimetry are also addressed.",book:{id:"4818",slug:"mine-action-the-research-experience-of-the-royal-military-academy-of-belgium",title:"Mine Action",fullTitle:"Mine Action - The Research Experience of the Royal Military Academy of Belgium"},signatures:"Yann Yvinec, Nada Milisavljevic, Charles Beumier, Idrissa\nMahamadou, Dirk Borghys, Michal Shimoni and Vinciane Lacroix",authors:[{id:"133433",title:"Dr.",name:"Yann",middleName:null,surname:"Yvinec",slug:"yann-yvinec",fullName:"Yann Yvinec"}]},{id:"55688",doi:"10.5772/66994",title:"The Special Case of Sea Mines",slug:"the-special-case-of-sea-mines",totalDownloads:2245,totalCrossrefCites:1,totalDimensionsCites:4,abstract:"In this chapter, work carried out at the Royal Military Academy regarding sea mines and mine countermeasures is summarized. Three sensors used for the detection and identification of sea mines are studied here: sonar, gradiometer and infrared camera. These sensors can be applied to detect different types of sea mines. Some signal and image processing techniques developed to extract relevant information for the detection of underwater objects are presented in this chapter. These techniques are validated using data collected in the frame of different European and NATO projects.",book:{id:"4818",slug:"mine-action-the-research-experience-of-the-royal-military-academy-of-belgium",title:"Mine Action",fullTitle:"Mine Action - The Research Experience of the Royal Military Academy of Belgium"},signatures:"Olga Lucia Lopera Tellez, Alexander Borghgraef and Eric Mersch",authors:[{id:"176830",title:"Dr.",name:"Olga",middleName:"Lucia",surname:"Lopera Tellez",slug:"olga-lopera-tellez",fullName:"Olga Lopera Tellez"}]},{id:"54115",doi:"10.5772/65784",title:"Positioning System for a Hand-Held Mine Detector",slug:"positioning-system-for-a-hand-held-mine-detector",totalDownloads:1241,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Humanitarian mine clearance aims at reducing the nuisance of regions infected by explosive devices. These devices need to be detected with a high rate of success while keeping a low false alarm rate to reduce time losses and personnel’s fatigue. This chapter describes a positioning system developed to track hand-held detector movements in the context of close-range mine detection. With such a system, the signals captured by the detector over time can be used to build two- or three-dimensional data. The objects possibly present in the data can then be visually appreciated by an operator to detect specific features such as shape or size or known signatures. The positioning system developed in the framework of the HOPE European project requires only a camera and an extra bar. It adds few constraints to current mine clearance procedures and requires limited additional hardware. The software developed for calibration and continuous acquisition of the position is described, and evaluation results are presented.",book:{id:"4818",slug:"mine-action-the-research-experience-of-the-royal-military-academy-of-belgium",title:"Mine Action",fullTitle:"Mine Action - The Research Experience of the Royal Military Academy of Belgium"},signatures:"Charles Beumier and Yann Yvinec",authors:[{id:"133433",title:"Dr.",name:"Yann",middleName:null,surname:"Yvinec",slug:"yann-yvinec",fullName:"Yann Yvinec"}]}],mostDownloadedChaptersLast30Days:[{id:"55272",title:"Ground‐Penetrating Radar for Close‐in Mine Detection",slug:"ground-penetrating-radar-for-close-in-mine-detection",totalDownloads:2890,totalCrossrefCites:3,totalDimensionsCites:5,abstract:"In this chapter, two of the major challenges in the application of ground‐penetrating radar in humanitarian demining operations are addressed: (i) development and testing of affordable and practical ground penetrating radar (GPR)‐based systems, which can be used off‐ground and (ii) development of robust signal processing techniques for landmines detection and identification. Different approaches developed at the Royal Military Academy in order to demonstrate the possibility of enhancing close‐range landmine detection and identification using ground‐penetrating radar under laboratory and outdoor conditions are summarized here. Data acquired using different affordable and practical GPR‐based systems are used to validate a number of promising developments in signal processing techniques for target detection and identification. 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Three sensors used for the detection and identification of sea mines are studied here: sonar, gradiometer and infrared camera. These sensors can be applied to detect different types of sea mines. Some signal and image processing techniques developed to extract relevant information for the detection of underwater objects are presented in this chapter. These techniques are validated using data collected in the frame of different European and NATO projects.",book:{id:"4818",slug:"mine-action-the-research-experience-of-the-royal-military-academy-of-belgium",title:"Mine Action",fullTitle:"Mine Action - The Research Experience of the Royal Military Academy of Belgium"},signatures:"Olga Lucia Lopera Tellez, Alexander Borghgraef and Eric Mersch",authors:[{id:"176830",title:"Dr.",name:"Olga",middleName:"Lucia",surname:"Lopera Tellez",slug:"olga-lopera-tellez",fullName:"Olga Lopera Tellez"}]},{id:"53185",title:"Testing and Evaluating Results of Research in Mine Action",slug:"testing-and-evaluating-results-of-research-in-mine-action",totalDownloads:1147,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This chapter summarizes the experience of the Royal Military Academy in testing and evaluating new tools for mine action. It first underscores the importance of testing and evaluating new methods in general and in mine action in particular. Some recommendations are given to help the design of test protocols: defining carefully the objectives of the test and what is to be measured, the importance of blind and double‐blind tests, choosing between realism and statistical relevance, the importance of how to display the results, etc. These recommendations are illustrated by real‐life examples, mainly from test and evaluation of detectors of mines in which RMA has been involved. A test protocol is detailed. It is the one that RMA designed and used to evaluate a detector that was proven to be useless and that led to the criminal conviction of its designer in the United Kingdom. Sources of available test protocols and test reports are also listed.",book:{id:"4818",slug:"mine-action-the-research-experience-of-the-royal-military-academy-of-belgium",title:"Mine Action",fullTitle:"Mine Action - The Research Experience of the Royal Military Academy of Belgium"},signatures:"Yann Yvinec",authors:[{id:"133433",title:"Dr.",name:"Yann",middleName:null,surname:"Yvinec",slug:"yann-yvinec",fullName:"Yann Yvinec"}]},{id:"53260",title:"Unmanned Ground and Aerial Robots Supporting Mine Action Activities",slug:"unmanned-ground-and-aerial-robots-supporting-mine-action-activities",totalDownloads:1314,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"During the Humanitarian‐demining actions, teleoperation of sensors or multi‐sensor heads can enhance-detection process by allowing more precise scanning, which is useful for the optimization of the signal processing algorithms. This chapter summarizes the technologies and experiences developed during 16 years through national and/or European‐funded projects, illustrated by some contributions of our own laboratory, located at the Royal Military Academy of Brussels, focusing on the detection of unexploded devices and the implementation of mobile robotics systems on minefields.",book:{id:"4818",slug:"mine-action-the-research-experience-of-the-royal-military-academy-of-belgium",title:"Mine Action",fullTitle:"Mine Action - The Research Experience of the Royal Military Academy of Belgium"},signatures:"Yvan Baudoin, Daniela Doroftei, Geert de Cubber, Jean‐Claude\nHabumuremyi, Haris Balta and Ioan Doroftei",authors:[{id:"176831",title:"Dr.",name:"Yvan",middleName:null,surname:"Baudoin",slug:"yvan-baudoin",fullName:"Yvan Baudoin"}]},{id:"52464",title:"InSAR Coherence and Intensity Changes Detection",slug:"insar-coherence-and-intensity-changes-detection",totalDownloads:1732,totalCrossrefCites:4,totalDimensionsCites:6,abstract:"This research aims at differentiating human-induced effects over the landscape from the natural ones by exploiting a combination of amplitude and phase changes in satellite radar images. 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Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",slug:"ana-isabel-flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",slug:"christian-palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",slug:"azhar-rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",slug:"sergey-sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",slug:"attilio-rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",slug:"yanfei-(jacob)-qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",slug:"arli-aditya-parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",slug:"cesar-lopez-camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]},overviewPageOFChapters:{paginationCount:42,paginationItems:[{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",doi:"10.5772/intechopen.105049",signatures:"Mohammed El-Gedamy",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"82875",title:"Lipidomics as a Tool in the Diagnosis and Clinical Therapy",doi:"10.5772/intechopen.105857",signatures:"María Elizbeth Alvarez Sánchez, Erick Nolasco Ontiveros, Rodrigo Arreola, Adriana Montserrat Espinosa González, Ana María García Bores, Roberto Eduardo López Urrutia, Ignacio Peñalosa Castro, María del Socorro Sánchez Correa and Edgar Antonio Estrella Parra",slug:"lipidomics-as-a-tool-in-the-diagnosis-and-clinical-therapy",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82440",title:"Lipid Metabolism and Associated Molecular Signaling Events in Autoimmune Disease",doi:"10.5772/intechopen.105746",signatures:"Mohan Vanditha, Sonu Das and Mathew John",slug:"lipid-metabolism-and-associated-molecular-signaling-events-in-autoimmune-disease",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82483",title:"Oxidative Stress in Cardiovascular Diseases",doi:"10.5772/intechopen.105891",signatures:"Laura Mourino-Alvarez, Tamara Sastre-Oliva, Nerea Corbacho-Alonso and Maria G. 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Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science\nand Technology from the Department of Chemistry, National\nUniversity of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013.\nShe relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the\nNational Institute of Fundamental Studies from April 2013 to\nOctober 2016. She was a senior lecturer on a temporary basis at the Department of\nFood Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is\ncurrently Deputy Principal of the Australian College of Business and Technology –\nKandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:{name:"Kobe College",institutionURL:null,country:{name:"Japan"}}}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. Her research interests include microalgal biotechnology with an emphasis on microalgae-based products.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}]},{type:"book",id:"7953",title:"Bioluminescence",subtitle:"Analytical Applications and Basic Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7953.jpg",slug:"bioluminescence-analytical-applications-and-basic-biology",publishedDate:"September 25th 2019",editedByType:"Edited by",bookSignature:"Hirobumi Suzuki",hash:"3a8efa00b71abea11bf01973dc589979",volumeInSeries:4,fullTitle:"Bioluminescence - Analytical Applications and Basic Biology",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/185746/images/system/185746.png",biography:"Dr. Hirobumi Suzuki received his Ph.D. in 1997 from Tokyo Metropolitan University, Japan, where he studied firefly phylogeny and the evolution of mating systems. He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. 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He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. 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Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"18",type:"subseries",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. 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The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",annualVolume:11423,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"275140",title:"Dr.",name:"Dinh Hoa",middleName:null,surname:"Nguyen",fullName:"Dinh Hoa Nguyen",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRbnKQAS/Profile_Picture_1622204093453",institutionString:null,institution:{name:"Kyushu University",institutionURL:null,country:{name:"Japan"}}},{id:"20259",title:"Dr.",name:"Hongbin",middleName:null,surname:"Ma",fullName:"Hongbin Ma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRhDJQA0/Profile_Picture_2022-05-02T08:25:21.jpg",institutionString:null,institution:{name:"Beijing Institute of Technology",institutionURL:null,country:{name:"China"}}},{id:"28640",title:"Prof.",name:"Yasushi",middleName:null,surname:"Kambayashi",fullName:"Yasushi Kambayashi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYOQxQAO/Profile_Picture_1625660525470",institutionString:null,institution:{name:"Nippon Institute of Technology",institutionURL:null,country:{name:"Japan"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/315001",hash:"",query:{},params:{id:"315001"},fullPath:"/profiles/315001",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()