The study of immune responses of peripheral blood in bone regeneration for bone formation predicting complications is relevant. Studies were carried out on patients with the facial skeleton injury before and after stable osteosynthesis of the mandible in a fixing device for external fixation. Of the 136 patients, 17 people’s bone tissue regeneration has been slow. Laboratory tests were carried out before and after the operation. The studies included the study of cellular immunity, humoral immunity, phagocytosis, acute phase proteins and cytokine status. The obtained data were processed using variation statistics methods and the modified theorem of T. Bayes. The study revealed that alternating stages of regeneration of bone tissue (inflammation, proliferation of osteoblasts, collagenogenesis and ossification) are accompanied by changes in the immunological status. A comparative study of the dynamics of immunological parameters at normal and slow osteogenesis had made it possible to establish criteria for delayed consolidation of bone tissue. Prognostic criteria before the operations include increasing the concentration of IgM and decreasing the concentration of C-reactive protein, in the early postoperative period-increasing the number of leukocytes, the concentration of tumor necrosis factor, IgM, as well as reducing the number of CD45+CD3+-cells, the complement activity and the amount of lactoferrin.
Part of the book: Clinical Implementation of Bone Regeneration and Maintenance