Biochemical composition and size of major lipoprotein types [8].
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This chapter starts by discussing the main compositional and structural properties of lipoproteins, which are water-soluble, heterogeneous nanoparticles responsible for carrying lipids, cholesterol and triglycerides in the body. The differences in their composition and structure are strictly related to how the different lipoproteins are produced and what their roles are in the body. We then move on to discuss the relationship between how lipoprotein type and lipoprotein subclass relate with the risk to develop atherosclerosis. We review recent evidence that suggests differences in low-density lipoprotein (LDL) overall size, shape and protein layer thicknesses within small dense LDL subfractions of normolipidemic and hyper triglyceridemic individuals. This is of importance since structural differences across a certain lipoprotein class or subclass are not taken into account in clinical studies and this might explain controversies in the role of, for example, small dense LDL in the development of atherosclerosis. We then move on to discuss how lipoprotein capacity for lipid transfer and lipid exchange has been studied along the years and focus on recent results that quantify these abilities using simplistic model membranes lacking specific receptors. Despite the simplicity of these model systems, the results mirror those obtained for cholesterol efflux and in clinicals studies. Finally, we discuss advances in plaque remodelling therapies based on the engineering of nanoparticles mimicking nascent high-density lipoprotein (HDL) particles with focus on the challenges for the formulation of therapies that are effective in the clinics.
Lipoproteins are the carriers of fat in the body. Plasma lipoproteins are secreted mostly by the liver and the intestine, whereas lipoproteins carrying lipids in the central nervous system are secreted mainly by the glial cells [1]. In Figure 1, the two ways by which plasma lipoproteins are formed are summarised. Chylomicrons, the largest and the least dense lipoprotein type, are produced in the intestine after a meal. Their size varies and depends on the amount of fat consumed during a meal. For instance, during fasting, chylomicrons are small and contain low amounts of triglycerides whereas a high-fat meal will result in the formation of larger particles, rich in triglycerides [2]. They undergo hydrolysis of triglycerides resulting in chylomicron remnants which are cleared
(A) Lipoprotein metabolism: Lipid-free ApoA1 is produced by both the intestine and the liver. It gains phospholipids and cholesterol
HDL formation and metabolism, on the other hand, starts with the production of apolipoprotein A1 (ApoA1) in the intestine and liver [4]. ApoA1 initial lipidation starts with the addition of both phospholipids and cholesterol from peripheral tissues
Lipoproteins are very heterogeneous in composition and differ in terms of their proportions of constituent proteins, cholesterol/cholesteryl esters, triglycerides and phospholipids (Table 1). The proteins responsible for the stability of the lipoprotein structure and their function in lipid transport and metabolism are known as apolipoproteins. Apolipoproteins vary in their size and overall structure, but they share a structure rich in amphipathic alpha helices, which are prone to interact with lipids and fats in aqueous environments such as plasma. In general, the larger the particle the higher the content ratio between lipids to proteins, which makes them less dense. Lipoproteins differ also in the main apolipoprotein they present. Apolipoprotein B100 (ApoB100) [9] is present only in VLDL, IDL and LDL, since they are all formed from chylomicrons. ApoB100 is one of the largest proteins known (~4500 residues) and therefore is irreversibly bound to these particles. The rest of the apolipoproteins are reversible and exchange between the different lipoprotein types. For example, Apolipoprotein C (ApoC) and Apolipoprotein E (ApoE) are commonly found in VLDL and LDL [10]. The main protein present in HDL is ApoA1, contributing to about 70% of total protein content in all HDL [10]. The second most abundant is Apolipoprotein A2 (ApoA2) [10] followed by a combination of various other proteins including ApoC, E and Apolipoprotein J. While almost all HDL contain ApoA1 [11], the remaining apolipoproteins vary across different HDL types and subclasses [10].
VLDL | LDL | HDL | |
---|---|---|---|
Diameter/ nm | 30–80 | 18–25 | 5–12 |
Cholesterol/% (w/w) | ~6 | ~7 | ~4 |
Phospholipids/% (w/w) | ~17 | ~21 | ~29 |
Triglycerides/% (w/w) | ~55 | ~6 | ~4 |
Protein/% (w/w) | ~8 | ~20 | ~50 |
Biochemical composition and size of major lipoprotein types [8].
As discussed previously, lipoprotein types vary drastically in their biochemical composition, which determines their size and density (Table 1). To further increase the degree of complexity, there are more subdivisions to these main categories. For example, using ultra-centrifugation, LDL can be subdivided in six subfractions which range from the large buoyant LDL (lbLDL) subfractions to the small dense LDL (sdLDL) subfractions [12, 13]. As their names suggest, these subfractions differ in size and density. For HDL, there are generally five distinct subpopulations with slight variations in composition, but most notably differences in size and density. HDL was first described by differences in density according to ultra-centrifugation techniques categorising HDL into two distinct groups [14]: i) HDL2, which is lower in density due to a higher lipid content (1.063–1.125 g mL−1), and ii) HDL3, which is slightly higher in density owing to its higher protein content (1.125–1.21 g mL−1). These groups can be further categorised by their size, using polyacrylamide gradient gel electrophoresis (GGE) resulting in five additional subclasses ranging in size from 7.2–12.0 nm in diameter [15]. By means of GGE, HDL particles can also be classified based on their surface charge into particles that migrate to either pre- β - or α-positions. Pre- β-position corresponds to lipid-free ApoA1, lipid-poor ApoA1, and most discoidal HDLs, whereas spherical, mature HDL migrate to α -position [16].
The structure of lipoproteins was studied already in the late 1970s by small angle X-ray scattering (SAXS) [13, 17, 18, 19] and in the early 1980s by small angle neutron scattering (SANS) [20]. It was then proposed their core-shell structure today widely accepted: lipoproteins are nanoparticles that consist of a core of cholesterol esters and triglycerides, with an outer monolayer of lipids and cholesterol, all encased by apolipoproteins. For the cholesterol richer LDL, a gel-liquid phase transition occurs below body temperature,
The updated LDL model based on SAXS data below (A) and above
Atherosclerosis is a chronic inflammatory disease considered to be the largest killer in western countries [26]. It is characterised by the plaque build-up in artery walls and can lead to cardiovascular diseases (CVD), giving rise to ischemic heart disease and strokes [27]. It is accepted that structural and compositional differences between HDL and LDL play a large role in their contributions to atherosclerosis [28]. The plaque build-up originates from LDL deposition into the artery walls [29], which are then oxidised and cause the upregulation of adhesion molecules on the surface of the endothelium of the arteries and the recruitment of monocytes to the forming lesion [30]. These then differentiate in macrophages which express scavenger receptors on their surface that mediate the uptake of even more LDL. This leads to the transformation of macrophages into foam cells, and the formation in the arteries of plaques that consist of apoptotic and necrotic macrophages, cholesterol crystals and other extracellular components [31]. Upon the rupture of these plaques, thrombus material enters the blood stream and can lead to heart attacks or other CVD related phenomena. As opposite to the role of LDL in atherosclerosis development, HDL have been instead shown to play a preventative role by a process known as reverse cholesterol transport (RCT) [32]. By this process, cholesterol is removed from the lipid-filled foam cells at the artery wall and deposited in the liver where it is cleared from the body [33, 34, 35]. The cholesterol removal occurs
There are several controversies regarding the role of HDL and LDL in the development of atherosclerosis. On one hand, increased levels of HDL are correlated to reduced atherosclerotic risk due to increased RCT efficiency [35] and, in some other cases, shown to have a neutral [38] or even negative correlation [39] to the prevention of atherosclerotic development. On the other hand, high LDL levels are related to high risk for development of atherosclerosis even though the total cholesterol LDL concentration often fails as a CVD biomarker [40]. This could be due to the pro-atherogenic effect of LDL [41] being counteracted by the anti-atherogenic effect of HDL [42]. Indeed, the ratio between LDL and HDL has been suggested as a better biomarker than their individual serum levels [40].
The LDL subclass distribution varies significantly within the population with two main LDL phenotypes [43]: the healthy one (phenotype A), enriched with lbLDL subfractions, and the unhealthy one (phenotype B), enriched with sdLDL subfractions [44] (Figure 2C). LDL size is an alleged marker for CVD risk since there is a positive correlation between LDL size and HDL concentration, and a negative correlation between LDL size and triglyceride concentration [43]. However, it is unclear whether it is the LDL concentration or their particle size which is the key parameter to predict CVD risk. Interestingly, there is some genetic, age and sex related predisposition for sdLDL. For example, a low-fat diet can contribute to a phenotype B in individuals with a genetic predisposition for sdLDL [45].
Recently, sdLDL fractions of normal and hyper triglyceridemic subjects were shown to have similar biochemical composition but different sizes and protein rich shell layer thicknesses [24] (Figure 2D). This suggests that LDL size and structure are not directly a consequence of composition and diet, mirroring the data found for individuals with a predisposition for sdLDL [45]. In particular, the protein rich shell layer thickness seems a very important parameter to consider since the protein conformation within this layer is determinant for further interaction with receptors and other biomolecules in the body. These structural analyses raise the following questions: are sdLDL subclasses from healthy and hyper triglyceridemic subjects equally pro-atherogenic? If not, is this due to the differences in the presence of specific apolipoproteins or post translational modifications in the protein-rich shell?
Finally, measuring total plasma cholesterol concentrations in clinics is
The role of the different HDL subclasses in the development of atherosclerosis is less studied and the results are controversial. A 2015 study found no evidence for any changes in HDL subclasses profiling for individuals with nonalcoholic fatty liver disease (NAFLD) [46], a disease associated with increased cardiometabolic risk. Another study found that HDL2b subclass was enriched in Hispanic women with LDL phenotype B [47]. Preliminary results from our group suggest that HDL main fractions and subfractions size differs between normolipidemic and hypertriglyceridemic individuals. These contrasting results indicate that more research is needed to understand the differences in HDL subclasses across various lipid metabolism disorders. Differences in HDL and LDL subclass structure rather than their relative proportion might be relevant for their function and their role in the development of atherosclerosis. Structural studies in combination with detailed compositional analysis by means of lipidomics and proteomics, as well as post-translational modifications, are needed to advance the field.
As already discussed, LDL function is counteracted by HDL function, and lipid exchange is a key process for their functions. Lipid exchange is known to be independent of protein exchange [48, 49, 50, 51]. Lipid exchange (where no net transfer takes place) and lipid transfer between lipoproteins of different types (
It is well accepted that there are several pathways for lipid transfer and cholesterol uptake. The main pathway is through receptor-mediated endocytosis, in which lipoprotein binding to LDL receptors takes place for ApoB100 and ApoE containing lipoproteins [59, 60]. Another mechanism involves scavenger receptor class B family (SR-B) receptors [61], that mediate the selective core lipid transfer from lipoprotein particles to cells and tissues. Lipid exchange and lipid transfer can potentially occur
Quantification of lipid exchange and transfer is challenging, and examples were scarce in literature until recently. Browning
Following reports using the same protocol showed that the inclusion of charged lipids in the model membranes led to unaffected quantity of lipids deposited but increased lipid removal by HDL [66]. The lipid exchange did not seem to affect the lipoprotein structure, as determined by SANS [57]. Then, the ability of the level of lipid unsaturation and of the presence of cholesterol to affect the lipid exchange capacity of lipoproteins was investigated [67]. The presence of acyl chain unsaturation dramatically decreased the quantities of lipids deposited and removed by the lipoproteins, regardless of the lipoprotein type (Figure 3). In other words, HDL and LDL have a greater affinity for saturated rather than unsaturated lipids, though LDL to a lesser extent. The difference in ease of lipid removal between the lipoprotein types could be explained by variance in the specific protein-lipid interactions. Different conformations of ApoA1 (the main protein in HDL) were shown to have varying binding affinities to unsaturated lipid vesicles [68]. The increased ease for saturated lipid removal is likely due to the increased mobility of said lipids within the fluid model membrane: saturated phospholipids were shown to have greater mobility than their unsaturated counterparts in both gel and fluid phases [69].
Relative lipid exchange and removal for HDL or LDL particles interacting with membranes formed with saturated (dDMPC) and unsaturated (dPC) phospholipids with and without cholesterol. Results are shown for HDL (A, B) and LDL (C, D) regarding exchange (A, C) and removal (B, D). Replotted with permission from Waldie
The presence of cholesterol also had a large impact on the amounts of lipids exchanged and removed [67] (Figure 3). In the bilayers comprising saturated lipids, the presence of cholesterol decreased the amounts of lipids exchanged and removed through HDL whereas, in the case of the unsaturated lipids, the presence of cholesterol made little difference when interacting with HDL. LDL, on the other hand, did not follow the same pattern. Indeed, including 10 mol% cholesterol in the saturated bilayer increased the amount of lipids exchanged. Upon further increasing to 20 mol%, a similar value was found to that of the saturated bilayer alone. For the unsaturated model membranes, the presence of 20 mol% cholesterol also gave similar values to that of the bilayer alone. However, in terms of removal, for both the saturated and unsaturated bilayers, the presence of cholesterol increasingly reduced the quantity of lipids removed. It is possible that the presence of cholesterol may inhibit the mobility of phospholipids [70] and cause it to localise preferentially towards saturated lipids [71]. However, there were no clear systematic changes when cholesterol was incorporated into the bilayer, thus it is difficult to pinpoint the exact cause of the changes seen. LDL has also been shown to preferentially bind to rafts of saturated lipid with cholesterol [72]. Since no reduction or increase in exchange was seen due to cholesterol, it is likely that the specific lipoprotein-lipid interactions determine the final quantities of lipids exchanged and removed.
To further look into this, LDL with differing compositions were used against the model membranes. It was found that with increasing density of LDL,
Access to the neutron beam is limited and highly specialised personnel are needed for these experiments. Methodology based on attenuated total reflection Fourier transfer infrared spectroscopy (ATR-FTIR) seems an accessible complementary alternative method to determine lipid exchange [75], which is far more accessible and exists in many laboratories as a benchtop technique.
As already discussed in Section 2, and as shown by Framingham Heart Study [76, 77] and later on by the Atherosclerosis Risk in Communities study [78], there is strong inverse association between HDL-cholesterol levels and CVD risk. Changes in lifestyle, such as weight loss, increase of physical activity, reduction in saturated fat intake, and low alcohol intake can alone increase HDL-cholesterol levels by up to 20%. However, lifestyle changes alone are not sufficient to prevent and reduce mortality in atherosclerosis. Thus, over the years there have been many pharmacological interventions aimed at raising circulatory HDL-cholesterol levels while decreasing LDL-cholesterol levels [79, 80, 81]. Nevertheless, these interventions have not resulted in the expected reduction in CVD events, suggesting that HDL functionality, rather than changes in HDL levels
ApoA1 mimetic peptides have also been explored in the treatment of the adverse effects of atherosclerosis. These have the advantage to be structurally simpler than the native full-length protein, although retaining the same biological functions, and have the potential to be administered orally instead of
Another apolipoprotein that has been suggested as a good candidate for HDL therapy is ApoE. ApoE is well known for its atheroprotective properties including the ability to induce RCT from peripheral cells to the liver [91] and to stimulate cholesterol efflux from macrophages thus, in turn, preventing the formation of foam cells in the development to atherosclerosis [92, 93]. Various studies have shown ApoE to have an increased ability to protect against atherosclerosis compared to ApoA1 [94]. The Ac-hE18A-NH2 ApoE mimetic has been shown to have a superior ability than the 4F ApoA1 mimetic to reduce atherosclerotic lesions in Apoe−/− mice [95]. The Ac-hE18A-NH2 mimetic has also demonstrated more effective anti-inflammatory properties than the 4F mimetic [96]. Most studies that have been carried out with the use of ApoE peptide mimetics are only in the pre-clinical trial stage and have not yet been tested in clinical studies for therapeutic use [94].
The variability of the outcomes of the pre-clinical and clinical studies described above points towards the need for a deeper understanding of the functionality (RCT and fat exchange, for example) and the structure of the HDL particles before considering them as a potential therapeutic for CVD. For example, a very recent study shows that the type of lipids used in the rHDL formulation has a significant effect on their ability to mediate cholesterol efflux [97], with saturated lipids having the greatest potential for cholesterol efflux. This mimics the results for fat exchange on simplistic models presented in Figure 3 and discussed in Section 4.1 in which saturated fats are more easily taken up by lipoproteins than unsaturated ones or those in the presence of cholesterol. Thus, not only the type of apolipoprotein but also the type of lipids used in the formulation have a fundamental role in the functionality of the rHDL and need to be further explored.
In this chapter we discussed the composition, function and structure of the two most studied lipoprotein types: LDL and HDL. In particular, we presented an updated model for determining the ultrastructure of LDL based on SAXS data that potentially enables determination of LDL phenotype from the total fraction measurement while highlighting structural differences in the small dense LDL subfraction between individuals with normal and high plasma serum triglyceride levels. Such differences, unknown until recently, may explain the different atherogenic potential of small dense LDL subfractions between different individuals and help unravel the controversies related to their atherogenic potential. Moreover, the capacity of lipoprotein fractions and subfractions to transfer lipids and cholesterol might be linked to these structural differences. Therefore, techniques that enable quantifying lipid exchange and lipid transfer in a reproducible and systematic manner are needed. We present recent data by fluorescence spectroscopy and neutron scattering showing how model cellular membranes lacking receptors can be used in the quantification of lipid exchange and lipid transfer by lipoproteins. In particular, the methodology might be especially useful when designing HDL therapy nanoparticles which require efficient removal of both saturated lipids and cholesterol from atherosclerotic plaque. Even though HDL therapy is quite promising in pre-clinics, it still has to show its potential in clinical studies.
The authors thank the Swedish Research Council for funding.
The authors declare no conflict of interest.
Viticulture is at the front line of climate change as grape production is highly sensitive to changing environmental conditions. Growers, producers, and investors plan and anticipate risks far into the future with long time horizons (i.e., 7–11 years or more) for investing, establishing, and attaining positive net income and returns on investment. Growers are grappling with unpredictable, rapidly changing weather patterns and more frequent and intense extreme events such as spring frosts, floods, droughts, heatwaves, and wildfires. Seasonal climate changes of hotter and longer summers and warmer winters are shifting areas suitable for growing grapes further north in the Northern Hemisphere (NH), and south in the Southern Hemisphere (SH), from historical cultivation latitudes of 4° and 51° (NH) and 6° and 45° (SH) [1]. This is driving wine makers to move vineyards to higher elevations that provide colder nighttime temperatures and less frequent and intense peak daytime temperatures to ripen grapes, while preventing over-ripening [2, 3]. Climate change warming scenarios project that grape cultivar diversity may buffer wine-growing regions from losses resulting from both the reduction of suitable areas for growing grapes and attainable yields. In a recent global study using data on long-term French records to extrapolate globally for 11 cultivars (varieties), increasing cultivar diversity more than halved future, projected losses of current wine-growing areas and decreasing areas lost (56 to 24%) under a 2°C warming scenario, and reducing areas lost by a third (85% versus 58%) under a 4°C warming scenario [4]. These warming scenarios combine daily temperature and precipitation from a large ensemble of the Community Earth System Model (CESM), alongside winegrape phenology and global variety-level planting data [5, 6], projecting geographical shifts of areas suitable for grape varieties as well as phenological shifts in the timing of grape ripening (veraison). The resulting loss of suitability of areas is primarily attributed to shifting temperature regimes, and greater accumulations of temperatures above 25°C, and number of days above 40°C. Precipitation was found to have a buffering effect, both reducing the number of varieties that were lost over time, while increasing the capacity for cultivar turnover [4]. While growing diverse cultivars that are more heat-tolerant and drought-resistant can reduce area and yield loss due to climate change impacts, the industry still faces the uncertainty and complexity associated with fulfilling the stringent consumer demands for quality, novelty, cost and sustainability of this agricultural product.
Big data (BD) is data that is machine-readable as opposed to human-readable. There is no official size that makes data “big”. It consists of massive amounts of digital information, collected from all sorts of sources that are too large, raw, or unstructured for analysis using conventional relational database and techniques. The internet-of-things (IoT) (i.e., the network of physical objects that exchanging data between devices, software, and systems over the Internet) continues to create BD and expand globally. Artificial intelligence (AI) refers to the simulation of human intelligence in machines that are programmed to think, learn and problem-solve like humans and mimic their actions. Machine learning (ML) is a sub-set of AI where machines learn from data without being explicitly programmed. Deep learning (DL) is a subset of ML in which artificial neural networks (ANNs) mimics the structure of the human brain, to adapt and learn from vast amounts of data. Algorithms are procedures that are implemented in computer code that use data, and are, in general, distinguished from models, which comprise many algorithms. BD needs to be of sufficient high quality to reliably train, validate, and independently test and/or reproduce algorithmic and model output at reported levels of accuracy and reliability. Here the goal is to design AI algorithms with a fast and efficient learning speed, fast convergence to a solution, good generalization ability and ease of implementation.
This review explores the benefits and challenges of BD and AI to sustainable viniviticulture through the lens of recent research findings and insights. Detailing all the different AI methodologies and their implementation is beyond the scope of this review that focuses on their domain application. For background reading of state-of-the-art AI methods and solution techniques, we direct interested readers to an article that features how vineyards are making use of BD [7], a recent introductory methodological reviews of ML in agriculture [8], and DL [9]. In the review conducted and reported here, recently published and highly relevant scientific journal articles were searched and selected using the University of Victoria (UVic)‘s Summons 2.0 search engine, which includes a wide range of scientific databases, including the Scopus, ScienceDirect and PubMed databases. A total of 59 articles were selected that met the required, minimal criteria that they assessed, applied, adapted, or developed an AI method/algorithm and addressed a main aspect linked with viniviticulture. This search approach was selective rather than exhaustive or systematic. The resulting sample size is similar to the 40 articles selected as part of another recent AI review which also employed online search of major scientific databases [8].
A systems overview of vitiviniculture interactions and drivers of change was first constructed. This was used to distinguish 10 major aspects under which a range of use-cases could be identified and linked across the selected works. This was informed, in part, by a broad review of vineyard ecosystems, their multifunctionality, and ecosystem services, applied the Common International Classification of Ecosystem Services (CICES) highlights the need to better identify and understand interactions within vineyards, identifying six ecosystem services (or aspects) that are most studied, namely: i) cultivated crops, ii) filtration and sequestration, iii) storage and accumulation, iv) pest and disease control, v) heritage and cultural services, and vi) scientific services (e.g., studying vineyard agronomy) [10]. Challenges identified and described within the selected articles were next extracted, compiled, and synthesized into a summary Table. A depiction or simplified design of a novel BD value chain informed by an ES comprising expert knowledge and providing an ES system with an ability to learn is presented. This is structured to encompass all the identified aspects and potentially capable of addressing current research challenges.
Viticulture is at the front line of technological disruption driven by automated, AI algorithms that integrate and learn from large complex data obtained from diverse sources both old and new. New technologies and data sources include satellite and drone remote-sensing, field sensors, and automated weather stations which are increasingly being deployed and used to enhance decision-making because of their increased availability, affordability, and reliability. For example, Palmaz vineyards in California’s Napa Valley are early-adopters of BD and AI, bringing innovation and invention to the ancient art of making wine. They use monitoring and geospatial technology for guidance and decision support. This includes VIGOR (Vineyard Infrared Growth Optical Recognition) to monitor and adjust conditions in the vineyard and an intelligent wine-making assistant, FILCS (Fermentation Intelligent Logic Control System), nicknamed Felix, and STAVES (Sensory Transambiental Variance Experiment) to monitor wines as they age in the barrel [11]. New decision-support tools have also been developed that use BD and AI technology provided by Sippd
While often used interchangeably, viti-culture refers to the science, study, and production of grapes, whereas vini-culture is specific to grapes for winemaking; when combined is vitiviniculture. According to the International Organization of Vine and Wine (OIV), sustainable vitiviniculture is a “global strategy on the scale of the grape production and processing systems, incorporating at the same time the economic sustainability of structures and territories, producing quality products, considering requirements of precision in sustainable viticulture, risks to the environment, products safety and consumer health and valuing of heritage, historical, cultural, ecological, and landscape aspects†(see [15] and references therein). While sustainable wines are currently a niche market, they are increasing in number, and consumers are willing to pay a premium for sustainably produced wines. Actions and guidance need to incorporate uncertainty and be fine-tuned to the local conditions and impacts. Grapevines phenotype (terroir), canopy micro-climate, vine growth and physiology, yield, and berry composition all contribute various attributes to wine and the degree to which it reflects its varietal origins and signature characteristics or typicity [1]. Vitiviniculture management is likely to become more complex. There are also stringent rules and regulations linked with production certification schemes and labelling systems for vineyards that apply organic, sustainable, biodynamic practices that include reducing environmental risks. The Summerhill Pyramid Winery based in Kelowna, British Columbia, Canada, for example, was certified in both organic under Canadian organic standards (PACS # 16-077, COR Section 345) in 1988 and Demeter biodynamic certification in 2012. Timely, suitable, and cost-effective adaptation strategies and enhanced foresight are crucial to support the complex dynamics and management of vitiviniculture.
There are three main types of learning:
ANNs comprise a collection of connected units or nodes called artificial neurons aggregated into different layers which transmit and process signals between their connections (edges). The signal of a given node is prescribed by a mathematical ‘activation’ function. Signals travel from a first ‘input’ layer, through one or more intermediate or ‘hidden’ layers, to an ‘output’ layer. Nodes in the hidden layer have values that are unknown and determined mathematically from their input and output signals as a network learns. Different layers may perform different transformations on their inputs. Connections can exist between nodes in different layers or between nodes within a given layer. Feedforward neural networks (FNNs) are a type of ANN having no memory, whereby signals only move in one direction from the input through to the output layer, never being processed by a node more than once. An extreme learning machine (ELM) is a FNN with a one or many hidden layers whose nodes can signal randomly, never update, or inherit previous signals without requiring any tuning of the mathematical function parameters of its node activation functions, or the weight values that alter the strength of how its inputs are connected within the network. A wide range of different DL model structures have evolved from FNNs. Recurrent neural networks (RNNs) are FNNs with memory whose nodes process signals in loops/feedbacks/cycles that considers current inputs and also what it has learned from previous inputs. Long-short-term-memory (LSTM) are a type of RNN that uses special units that include a ‘memory cell’ that maintains information in memory for longer periods of time. Convolutional neural networks (CNNs) have several layers whose nodes are sparsely connected (i.e., nodes are not fully connected) whose flexibility is particularly useful for image recognition and object classification. A CNN typically comprises four types of layers, namely, the convolution layer, rectifier (ReLU) layer, pooling, and fully connected layers. Every layer has its own functionality and performs feature extractions and discovers hidden patterns in input data. RNNs can use sequential information, while CNNs cannot.
Restricted boltzman machines (RBM) consist of a two-layer network of fully connected nodes with both forward and backwards connections (i.e., a cycle) that can share weights (i.e., bidirectional). This two-layer network was originally designed to better determine good starting weights (i.e., pretraining) of FNNs. A deep belief network (DBN) consists of RBMs which are sequentially connected, comprising multiple hidden layers, with connections between hidden units are in separate layers. Deep q-learning networks (DQLNs) use reinforcement learning to make a sequence of decisions through trial and error within an interactive environment involving ‘agents’ that have ‘states’ that change, learn, and adapt over time. Q-learning is a specified form of reinforcement learning (i.e., values-based learning) that is model-free i.e., does not require a model of the environment. It learns expected values of future rewards for actions of agents that are in a given state with a given ‘value’. It uses q-learning (i.e., learning from delayed rewards) based on Bellman’s Equation that decomposes the value of an agent’s state into an immediate reward and the value of a cumulative set of successor states according to a discount factor that determines the importance of future rewards. Bayesian learning (or belief) networks (BLNs) are a type of network model that is stochastic or probabilistic and involves ‘priors’. Prior is short for ‘prior probability distribution’ and is the probability distribution that express one’s beliefs about an uncertain quantity before some data or further evidence is taken into account. They are used to represent spatial or temporal dependence (represented by conditional probability distribution functions) between multiple stochastic variables (i.e., nodes), describing how the variables depend on each other in terms of cause-and-effect or causality (i.e., connections or arcs between nodes). Variables can be discrete or continuous. BLNs can be prepared by experts or learned from data, then used for inference to estimate the probabilities for causal or subsequent events. Copula bayesian networks (CBNs) use a tailored mathematical function called a copula that provides an efficient way to represent and compute the joint probability represented by such networks along with how its variables depend on each other.
New methods and frameworks to use and integrate BD and AI for complex problem-solving and enhanced decision making will, very likely, be needed to support sustainable vitiviniculture. Such approaches will need to consider complex interactions between climate, biotic, and abiotic drivers, stressors, and risks within vineyards, influencing grape and wine production, and value-chain resiliency and sustainability (Figure 1).
Overview of the interactions of major climate, biotic, and abiotic drivers, stressors, and risks within vineyards.
Structured data is highly organized and easily understood by machine language, whereas unstructured data is often categorized as qualitative data that cannot be processed and analyzed using conventional tools and methods and includes text, video files, audio files, mobile activity, social media posts, and satellite imagery. BD can include also vague and imprecise information, qualitative data, and rule-based logic. An expert system (ES) is a computer program, model, or algorithm that uses AI to simulate the judgment and behavior of a human or an organization that has expert knowledge and experience in a particular domain or field. It provides supervision for AI algorithms by human experts termed human-in-the-loop (HITL), whereby a model requires human interaction and intervention and is not fully automated or self-reliant. AI in winemaking based on an ES approach was explored in 2000 [16], with limited research on ES, and closely associated, fuzzy inference systems (FIS) in viniviticulture. Fuzzy theory and FIS represent vagueness and imprecise information often used in making decision in a mathematical way using fuzzy sets and rule-based logic. Several leading examples are noteworthy. An ES for automated forecasting of optimal grape ripeness dates using data gathered from a vineyard wireless sensor network (WSN) has been developed and tested, but uses the Holt method (exponential adaptive forecasting for trended data) instead of ML or DL models/algorithms [17]. Also, an FIS that enables automating the classification of grape quality at harvest for grape growers has been developed and tested [18]. An ES for evaluating the sustainability of vineyards based on their management called Vigneto uses a fuzzy logic indicator [19]. A decision support system called FGRAPEDBN that uses fuzzy logic and expert knowledge is able to predict grape berry maturity. Berry maturity is measured as sugar concentration that increases rapidly, and acidity concentration, that decreases along with pH levels as berry mature. This ES attains high predictive accuracy (i.e., a root-mean-squared-error (RMSE) of 7 g/l (i.e., 0.44 g/l or 0.11 g/kg) [20]. The coupling of ES to AI (i.e., ML and DL models/algorithms) in viticulture, or agriculture in general, is still unexplored and in its infancy. Also, ES systems generally have no ability to learn decision rules, so could benefit also from being informed by AI/ML analytics and predictive insights.
A wide array of applications and use-cases of AI in vitiviniculture are evident, and are summarized in Table 1. This shows that there is substantial interest, applied expertise, and future potential in developing such approaches to help mitigate and adapt to climate change, address inter-related risks, and enhance decision-making and foresight. Current AI work is, however, concentrated heavily on grapevine yield prediction and grape variety classification using on the pattern recognition, detection, counting, and clustering of grape berries and bunches in imagery collected by observers, unmanned aerial vehicles (UAVs), and/or robots. Such imagery differs based on vineyard environmental conditions and grape variety altering illumination, occlusions, colors and contrast in images. Existing research limitations and challenges point to the need for robotics and mobile sensing platforms, the combination or fusion of both fine-scale hyperspectral and coarser-scale multispectral imagery data, as well as spatially-distributed sampling within vineyards to better measure and assess micro-climate variability linked with meso- and macro-climate and landscape suitability requirements that are changing with climate change.
Aspect | Use-cases | Method/algorithm | Current challenges | References |
---|---|---|---|---|
Suitability requirements | detect, segment vineyards | CNN | spectral distortions dependent on wavelength, image acquisition parameters | [21, 22] |
Grape/grape bunch detection | non-invasive, automated cluster compactness, variety discrimination, classification, tracking | DNN, CNN, AdaBoost and RWNN, SVM, ANN | high-quality training and validation data (different varieties, illumination conditions) | [23, 24, 25, 26, 27, 28, 29, 30, 31] |
Disease and pest control | disease forecasting, automated detection and differentiation of diseases from leaf images | hybrid BLN, CNN, RF, GB | vineyard data on grape yield, disease imagery to validate models for different varieties, diseases, vineyards, climatic zones; deploying imaging systems on ground vehicles | [32, 33, 34, 35] |
Vineyard management, grape growing | automated grape vine pruning; irrigation, nutrients | RNN with LSTM, Case-based reasoning (CBR)11 | learning rules of expert pruners; broader method testing; including inter-annual variability due to weather, climate; | [36, 37] |
Biotic factors and stress | automated insect trapping; rhizogenesis and acclimatization; soil microbial biomass | ANN, genetic algorithm | expanding training data and introducing more parameters regarding soil physical properties and management | [38, 39, 40] |
Abiotic factors and stress | water stress from hyperspectral imagery; heat stress from Sentinel-2 multispectral imagery | RF, EGB | classification using the widely-applied Savitzky–Golay smoothed spectra reduces accuracy | [41, 42, 43] |
Grapevine phenology detection, yield prediction | grape berry maturity, yield prediction | fuzzy logic, dynamic BLN | reducing uncertainty with an integration of expert knowledge | [20, 44, 45, 46, 47, 48] |
Wine aroma, sensory profiling | vertical vintage using near-infrared spectroscopy (NIR); weather/management data | Clustering, GO | coupling models to data using new and emerging technologies to make these analyses more affordable and user-friendly | [49, 50] |
Wine quality, classification | wine preferences from physicochemical properties, organic acids; abnormal fermentation detection; wine blending, AI consultant; preference prediction | ANN,SVM | greater use, adoption of novel models/tools, cost–benefit analysis | [12, 14, 51, 52, 53, 54, 55] |
Traceability, authenticity, protection | incident handling in wine storage; authenticity assessment; wine aging prediction; constructing wine barrels, smoke exposure | clustering, dimensional reduction | greater use, adoption of novel models/tools, cost–benefit analysis | [56, 57, 58, 59, 60, 61, 62] |
Showcase of AI/ML in vitiviniculture (partial set from the review).
Refer to abbreviation list for model/algorithms.
Suitability requirements for vineyards would benefit from other AI/ML techniques to explore geospatial data and cross-validate geographical locations determined from CNN models applied to identify vineyards in satellite data. A wide range of different models for disease and pest control (i.e., a hybrid BLN, CNN, RF, GB) have been applied, and these multiple AI approaches could be coupled to provide a fully-integrated solution for processing field imagery, conducting data mining and analytics, and forecasting of disease risk in vineyards. Vineyard management is already exploring decision rule applications via case-based reasoning, and sequential methods of AI, but in isolation, and such work could greatly benefit from being coupled together to accelerate advancement. This would enable them to be tested on a broader set of vineyard data and to better identify best management practices, rather than a more incremental, siloed approach. Much more work is needed to explore opportunities and potential of BD and AI in vineyard biotic and abiotic factors and stress. Only a handful of studies have explored the use of satellite remote-sensing (i.e., Earth Observation or EO) data for detecting and mapping water and heat stress, yet large amounts of data for training and validating AI models now exists from EO data centers and providers. This could help to validate whether satellite indices can reliably detect and map stress variability in vineyard, what data fusion and satellite indices perform best, to port such BD and capabilities to support stakeholders proactive decision making ahead of extreme weather impacts like heatwaves. Most work on wine aroma and sensory profiling still employs traditional statistical techniques and clustering with limited work on global optimization (GO). While decision tools already exist in the market to track the wine preferences of consumers, they could be better informed from AI analysis and prediction that links more objective, scientific data on new varieties, wine constituents, alternative wine blends and new wine grown in newly establish vineyards in more suitable areas as climate change shifts grape and wine suitability. The application of BD and AI in traceability, authenticity, and protection also relies on more traditional statistical methods, rather than BD and AI. This is surprising and was not expected before conducting this review, as this area involves large extents of the value-chain and major business risk. Here, government could play a vital role to co-design and pilot test new solutions alongside experts in BD and AI, as developing broad-based solutions in this aspect likely require broad collaboration, multidisciplinary expertise, substantial BD collection and sharing, and industry wide involvement, adoption, and deployment.
An existing ontology framework called the Agri-Food Experiment Ontology (AFEO) has been developed to guide the integration of data in a way that provides researchers with the information necessary to address extended research questions [63]. It contains 136 concepts spanning viticulture practices, wine-making products, and operations. It utilizes the Resource Description Framework (RDF) format, a standard model for relational data queries, interchange, and metadata processing, to represent these data in a standard format. Based on this review, an analytical framework is proposed that integrates BD analytics and AI prediction as part of a BD value-chain using expert knowledge as HITL intervention and guidance is outlined in Figure 2.
Depiction of a vineyard BD value-chain that incorporates diverse, distributed vineyard data alongside an expert system. This system integrates traditional, cultural perspectives, knowledge, and reasoning of grape growers, viticulture specialists, and other wine industry stakeholders.
BD is distributed across different remote-sensing platforms (e.g., drone and satellite), across vineyards (e.g., networks of AI and climate-smart vineyards), and within vineyards (e.g., field sensor networks), and across data centers and providers (e.g., long-term climate stations and weather monitoring networks providing both historical climate and near-real-time weather station data). Using a distributed cloud approach, an application of cloud computing technology, BD can be interconnected with public and private applications served from varied geographical locations for preprocessing quality control, data quality checks, model identification (i.e., variable selection, quantile classification), indicator model benchmarking, and the development of risk forecast models using AI. An ES system comprising conditional, decision rules provides traditional and expert knowledge, while informing AI model training and validation. An AI model then also learns by selecting rules from the master ES ruleset, adjusting and updating rules as it learns. In this way, the framework is agile and scaleable to address a wide range of stakeholder needs along the value-chain. This includes life-cycle assessment (LCA), providing data to support monitoring and tracking of vineyard sustainability indicators, and providing forecasts (i.e., foresight) to better anticipate future impacts, having additional lead time to mitigate and safeguard operations in time, and deciding between different possible actions and interventions to climate change (i.e., irrigation needs and limitations, disease outbreaks, extreme weather events) risks for more informed vineyard management scheduling and planning. Weather and climate transformed into tailored information and knowledge that vineyard stakeholders and users need and require are provided through customized Climate Information Services (CIS) help to drive forecasts of relevant vineyard indicators. This could integrate sub-seasonal and seasonal forecasting, alongside longer-term, downscaled inter-annual and decadal scenario projections. The quantification of risk (i.e., levels and associated uncertainties) is essential to determine an appropriate response. With an approach that can be scaled up to the entire vitiviniculture value-chain the adoption of BD and AI can be accelerated. This would enable all stakeholders to co-learn and collaborate in evidence-based and model-tested design tactics and strategies. Such an approach can ensure mitigation and adaptation actions and interventions are enabling, rather than inhibiting, to maximize perceived benefits and organizational readiness, while minimizing external pressures [64].
Vineyards that are certified organic and biodynamic, however, are not necessarily the same ones that are early- or significant-adopters of latest BD and AI technology that can accelerate and support the wider transformation from conventional to sustainable vitiviniculture practices. As discussed, this is because of a disconnect that exists between the path to adoption of sustainable practices and the path to adoption of BD and AI technology. This could be addressed by providing a way to structure and integrate an expert knowledge and insights from all stakeholders into an ES embedded within an overarching analytical framework. The majority of research challenges identified in this review, which span a wide range of aspects of viniviticulture, also point to the need for including expert knowledge to provide context and rules to design AI algorithms and their automated learning, while helping to structure data, obtain high-quality data for training AI models, and validate the use and adoption of new BD types and sources. Aligning the existing AFEO ontology that links vitiviniculture objects and experimental activities to an analytical BD and AI modeling, could accelerate the advancement of sustainable vitiviniculture. This would also provide the ES methodology with an ability to learn from experience which most systems cannot do currently. ML and DL models and algorithms need to be trained and informed by an ES that integrates imprecise and vague information as well as qualitative data and decision rule-based logic that is used in stakeholder decision making. This will require linking the scientific and expert knowledge on climate and weather risks pertaining to drivers and interactions, the BD value chain, to address the identified research challenges outlined here. Future work will aim to synthesize knowledge and insights from the wide array of applications of ES, to design a representative ES for the proposed BD value chain.
NKN acknowledges viticulture research funding support from the Canadian Agricultural Partnership (CAP) Program, Agriculture and Agri-Food Canada (AAFC) under project no. 2336, ‘Influence of cultural practices and climate change on sustainability of grape production under northern conditions’. I thank Dr. T.A. Porcelli for helpful editing and feedback.
The authors declare no conflict of interest.
AI | Artificial intelligence |
ANN | Artificial neural network |
AFEO | Agri-Food Experiment Ontology |
BLN | Bayesian learning network |
BD | Big data |
CBR | Case-based reasoning via a learning-based adaptation strategy |
CESM | Community Earth System Model |
CICES | Common International Classification of Ecosystem Services |
CIS | Climate Information Services |
CNN | Convolutional neural network |
CBN | Copula bayesian network |
DL | Deep learning |
DQLN | Deep q-learning neural network |
DSS | Decision-support system |
EGB | Extreme gradient boosting via second-order derivative approximation (XGBoost) |
EBM | Extreme learning machine |
EO | Earth observation |
ES | Expert system/s |
FIS | Fuzzy inference system/s |
FNN | Feed-forward neural network |
GB | Gradient boosting via gradient decent |
GO | Global optimization (constrained) |
HITL | Human-in-the-loop |
LCA | Life-cycle assessment |
LSTM | Long short-term memory architecture |
ML | Machine learning |
IOV | International Organization of Vine and Wine |
IOT | Internet-of-things |
RDF | Resource Description Framework |
RF | Random forest ensemble learning |
RMSE | Root-mean-squared-error |
RNN | Recurrent neural network |
RBM | Restricted boltzman machine |
RWNN | AdaBoost and random weight neural network |
SVM | Support vector machine |
UAV | Unmanned aerial vehicles |
WSN | Wireless sensor network |
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René"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10882",title:"Smart Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"70c3ce4256324b3c58db970d446ddac4",slug:"smart-drug-delivery",bookSignature:"Usama Ahmad, Md. Faheem Haider and Juber Akhtar",coverURL:"https://cdn.intechopen.com/books/images_new/10882.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10885",title:"Snake Venom and Ecology",subtitle:null,isOpenForSubmission:!1,hash:"cc4503ed9e56a7bcd9f2ca82b0c880a8",slug:"snake-venom-and-ecology",bookSignature:"Mohammad Manjur Shah, Umar Sharif, Tijjani Rufai Buhari and Tijjani Sabiu Imam",coverURL:"https://cdn.intechopen.com/books/images_new/10885.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"94128",title:"Dr.",name:"Mohammad Manjur",middleName:null,surname:"Shah",slug:"mohammad-manjur-shah",fullName:"Mohammad Manjur Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10381",title:"Electrocatalysis and Electrocatalysts for a Cleaner Environment",subtitle:"Fundamentals and Applications",isOpenForSubmission:!1,hash:"9dbafb0b297cf5cbdb220707e022a228",slug:"electrocatalysis-and-electrocatalysts-for-a-cleaner-environment-fundamentals-and-applications",bookSignature:"Lindiwe Eudora Khotseng",coverURL:"https://cdn.intechopen.com/books/images_new/10381.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"236596",title:"Dr.",name:"Lindiwe Eudora",middleName:null,surname:"Khotseng",slug:"lindiwe-eudora-khotseng",fullName:"Lindiwe Eudora Khotseng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10900",title:"Prunus",subtitle:"Recent Advances",isOpenForSubmission:!1,hash:"9261926500acb26c4ae5a29eee78f0db",slug:"prunus-recent-advances",bookSignature:"Ayzin B. Küden and Ali Küden",coverURL:"https://cdn.intechopen.com/books/images_new/10900.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"200365",title:"Prof.",name:"Ayzin B.",middleName:"B.",surname:"Küden",slug:"ayzin-b.-kuden",fullName:"Ayzin B. Küden"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"1217",title:"Hydrostatics",slug:"hydrostatics",parent:{id:"224",title:"Fluid Mechanics",slug:"physics-fluid-mechanics"},numberOfBooks:4,numberOfSeries:0,numberOfAuthorsAndEditors:122,numberOfWosCitations:93,numberOfCrossrefCitations:67,numberOfDimensionsCitations:137,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"1217",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"6126",title:"Colorimetry and Image Processing",subtitle:null,isOpenForSubmission:!1,hash:"f74525de04361957bd947a45b0e64378",slug:"colorimetry-and-image-processing",bookSignature:"Carlos M. Travieso-Gonzalez",coverURL:"https://cdn.intechopen.com/books/images_new/6126.jpg",editedByType:"Edited by",editors:[{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5370",title:"Vortex Dynamics and Optical Vortices",subtitle:null,isOpenForSubmission:!1,hash:"bf45ea3936725da5f92207f7709d24ab",slug:"vortex-dynamics-and-optical-vortices",bookSignature:"Hector Perez-de-Tejada",coverURL:"https://cdn.intechopen.com/books/images_new/5370.jpg",editedByType:"Edited by",editors:[{id:"79235",title:"Dr.",name:"Hector",middleName:null,surname:"Perez-De-Tejada",slug:"hector-perez-de-tejada",fullName:"Hector Perez-De-Tejada"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6028",title:"Vortex Structures in Fluid Dynamic Problems",subtitle:null,isOpenForSubmission:!1,hash:"3e6874ea59cb10b653cd2190b941c7f5",slug:"vortex-structures-in-fluid-dynamic-problems",bookSignature:"Hector Perez-de-Tejada",coverURL:"https://cdn.intechopen.com/books/images_new/6028.jpg",editedByType:"Edited by",editors:[{id:"79235",title:"Dr.",name:"Hector",middleName:null,surname:"Perez-De-Tejada",slug:"hector-perez-de-tejada",fullName:"Hector Perez-De-Tejada"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1013",title:"Advanced Fluid Dynamics",subtitle:null,isOpenForSubmission:!1,hash:"3f86d73b26da7f53a683a7348acbf2d0",slug:"advanced-fluid-dynamics",bookSignature:"Hyoung Woo Oh",coverURL:"https://cdn.intechopen.com/books/images_new/1013.jpg",editedByType:"Edited by",editors:[{id:"63199",title:"Prof.",name:"Hyoung Woo",middleName:null,surname:"Oh",slug:"hyoung-woo-oh",fullName:"Hyoung Woo Oh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:4,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"31572",doi:"10.5772/26045",title:"Fuel Jet in Cross Flow - Experimental Study of Spray Characteristics",slug:"fuel-jet-in-cross-flow-experimental-study-of-spray-characteristics",totalDownloads:4785,totalCrossrefCites:13,totalDimensionsCites:36,abstract:null,book:{id:"1013",slug:"advanced-fluid-dynamics",title:"Advanced Fluid Dynamics",fullTitle:"Advanced Fluid Dynamics"},signatures:"E. Lubarsky, D. Shcherbik, O. Bibik, Y. Gopala and B. T. Zinn",authors:[{id:"65353",title:"Dr.",name:"Eugene",middleName:null,surname:"Lubarsky",slug:"eugene-lubarsky",fullName:"Eugene Lubarsky"}]},{id:"57228",doi:"10.5772/intechopen.71002",title:"Thresholding Algorithm Optimization for Change Detection to Satellite Imagery",slug:"thresholding-algorithm-optimization-for-change-detection-to-satellite-imagery",totalDownloads:1655,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"To detect changes in satellite imagery, a supervised change detection technique was applied to Landsat images from an area in the south of México. At first, the linear regression (LR) method using the first principal component (1-PC) data, the Chi-square transformation (CST) method using first three principal component (PC-3), and tasseled cap (TC) images were applied to obtain the continuous images of change. Then, the threshold was defined by statistical parameters, and histogram secant techniques to categorize as change or unchanged the pixels. A threshold optimization iterative algorithm is proposed, based on the ground truth data and assessing the accuracy of a range of threshold values through the corresponding Kappa coefficient of concordance. Finally, to evaluate the change detection accuracy of conventional methods and the threshold optimization algorithm, 90 polygons (15,543 pixels) were sampled, categorized as real change/unchanged zones, and defined as ground truth, from the interpretation of color aerial photo slides aided by the land cover maps to obtain the omission/commission errors and the Kappa coefficient of agreement. The results show that the threshold optimization is a suitable approach that can be applied for change detection analysis.",book:{id:"6126",slug:"colorimetry-and-image-processing",title:"Colorimetry and Image Processing",fullTitle:"Colorimetry and Image Processing"},signatures:"René Vázquez-Jiménez, Rocío N. Ramos-Bernal, Raúl Romero-\nCalcerrada, Patricia Arrogante-Funes, Sulpicio Sanchez Tizapa and\nCarlos J. Novillo",authors:[{id:"213505",title:"Dr.",name:"René",middleName:null,surname:"Vázquez-Jiménez",slug:"rene-vazquez-jimenez",fullName:"René Vázquez-Jiménez"},{id:"213527",title:"Dr.",name:"Raúl",middleName:null,surname:"Romero-Calcerrada",slug:"raul-romero-calcerrada",fullName:"Raúl Romero-Calcerrada"},{id:"213529",title:"Dr.",name:"Rocío N.",middleName:null,surname:"Ramos-Bernal",slug:"rocio-n.-ramos-bernal",fullName:"Rocío N. Ramos-Bernal"},{id:"213530",title:"MSc.",name:"Patricia",middleName:null,surname:"Arrogante-Funes",slug:"patricia-arrogante-funes",fullName:"Patricia Arrogante-Funes"},{id:"213531",title:"Dr.",name:"Carlos J.",middleName:null,surname:"Novillo",slug:"carlos-j.-novillo",fullName:"Carlos J. Novillo"},{id:"221412",title:"Dr.",name:"Sulpicio",middleName:null,surname:"Sánchez-Tizapa",slug:"sulpicio-sanchez-tizapa",fullName:"Sulpicio Sánchez-Tizapa"}]},{id:"53153",doi:"10.5772/66343",title:"Fractal Light Vortices",slug:"fractal-light-vortices",totalDownloads:1791,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"Vortex lenses produce special wavefronts with zero-axial intensity, and helical phase structure. The variations of the phase and amplitude of the vortex produce a circular flow of energy that allows transmitting orbital angular momentum. This property is especially in optical trapping, because due to the orbital angular momentum of light, they have the ability to set the trapped particles into rotation. Vortex lenses engraved in diffractive optical elements have been proposed in the last few years. These lenses can be described mathematically as a two-dimensional (2D) function, which expressed in polar coordinates are the product of two different separable one-dimensional (1D) functions: One, depends only on the square of radial coordinate, and the other one depends linearly on the azimuthal coordinate and includes the topological charge. The 1D function that depends on the radial coordinate is known as a zone plate. Here, vortex lenses, constructed using different aperiodic zone plates, are reviewed. Their optical properties are studied numerically by computing the intensity distribution along the optical axis and the transverse diffraction patterns along the propagation direction. It is shown that these elements are able to create a chain of optical traps with a tunable separation, strength and transverse section.",book:{id:"5370",slug:"vortex-dynamics-and-optical-vortices",title:"Vortex Dynamics and Optical Vortices",fullTitle:"Vortex Dynamics and Optical Vortices"},signatures:"Federico J. Machado, Juan A. Monsoriu and Walter D. Furlan",authors:[{id:"186344",title:"Prof.",name:"Walter",middleName:null,surname:"Furlan",slug:"walter-furlan",fullName:"Walter Furlan"}]},{id:"58322",doi:"10.5772/intechopen.72603",title:"Image Segmentation Based on Mathematical Morphological Operator",slug:"image-segmentation-based-on-mathematical-morphological-operator",totalDownloads:1557,totalCrossrefCites:2,totalDimensionsCites:7,abstract:"Image segmentation is the process of partitioning a digital image into multiple regions (sets of pixels); the pixels in each region have similar attributes. It is often used to separate an image into regions in terms of surfaces, objects, and scenes, especially for object location and boundary extraction. Until now, many general-purpose algorithms and techniques have been proposed for image segmentation. Typical and traditional methods are: (1) threshold-based method; (2) edge-based method; and (3) region-based method. In this chapter, we propose an approach of image segmentation based on mathematical morphology operator: toggle operator. The experimental result shows that the proposed method can segment natural scene images into homogeneous regions effectively.",book:{id:"6126",slug:"colorimetry-and-image-processing",title:"Colorimetry and Image Processing",fullTitle:"Colorimetry and Image Processing"},signatures:"Jianjun Chen, Haijian Shao and Chunlong Hu",authors:[{id:"212306",title:"Ph.D.",name:"Jianjun",middleName:null,surname:"Chen",slug:"jianjun-chen",fullName:"Jianjun Chen"}]},{id:"53041",doi:"10.5772/66323",title:"Partially Coherent Vortex Beam: From Theory to Experiment",slug:"partially-coherent-vortex-beam-from-theory-to-experiment",totalDownloads:2050,totalCrossrefCites:5,totalDimensionsCites:7,abstract:"Partially coherent vortex beam exhibits some unique and interesting properties, for example, correlation singularities (i.e., ring dislocations) exist in its correlation function, and one can determine the magnitude of the topological charge of the vortex phase from the number of the ring dislocations. Modulating the coherence of a vortex beam provides a convenient way for shaping its focused beam spot, which is useful for material processing and optical trapping. Furthermore, a partially coherent vortex beam has an advantage over a partially coherent beam without vortex phase for reducing turbulence‐induced scintillation, which will be useful in free‐space optical communications. We introduce recent theoretical and experimental developments on partially coherent vortex beams.",book:{id:"5370",slug:"vortex-dynamics-and-optical-vortices",title:"Vortex Dynamics and Optical Vortices",fullTitle:"Vortex Dynamics and Optical Vortices"},signatures:"Xianlong Liu, Lin Liu, Yahong Chen and Yangjian Cai",authors:[{id:"186341",title:"Prof.",name:"Yangjian",middleName:null,surname:"Cai",slug:"yangjian-cai",fullName:"Yangjian Cai"},{id:"194234",title:"Dr.",name:"Xianlong",middleName:null,surname:"Liu",slug:"xianlong-liu",fullName:"Xianlong Liu"},{id:"194235",title:"Dr.",name:"Lin",middleName:null,surname:"Liu",slug:"lin-liu",fullName:"Lin Liu"},{id:"194236",title:"Dr.",name:"Yahong",middleName:null,surname:"Chen",slug:"yahong-chen",fullName:"Yahong Chen"}]}],mostDownloadedChaptersLast30Days:[{id:"53106",title:"Dynamical Particle Motions in Vortex Flows",slug:"dynamical-particle-motions-in-vortex-flows",totalDownloads:2264,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Circular vortex flows generate interesting self-organizing phenomena of particle motions, that is, particle clustering and classification phenomena. These phenomena result from interaction between vortex dynamics and relaxation of particle velocity due to drag. This chapter introduces particle clustering in stirred vessels and particle classification in Taylor vortex flow based on our previous research works. The first part of this chapter demonstrates and explains a third category of solid-liquid separation physics whereby particles spontaneously localize or cluster into small regions of fluids by taking the clustering phenomena in stirred vessels as an example. The second part of this chapter discusses particle classification phenomena due to shear-induced migration. Finally, this chapter discusses about process intensification utilizing these self-organizing phenomena of particle motions in vortex flows.",book:{id:"5370",slug:"vortex-dynamics-and-optical-vortices",title:"Vortex Dynamics and Optical Vortices",fullTitle:"Vortex Dynamics and Optical Vortices"},signatures:"Steven Wang and Naoto Ohmura",authors:[{id:"186403",title:"Prof.",name:"Naoto",middleName:null,surname:"Ohmura",slug:"naoto-ohmura",fullName:"Naoto Ohmura"},{id:"187311",title:"Dr.",name:"Steven",middleName:null,surname:"Wang",slug:"steven-wang",fullName:"Steven Wang"}]},{id:"53651",title:"Vortex Spinning System and Vortex Yarn Structure",slug:"vortex-spinning-system-and-vortex-yarn-structure",totalDownloads:5014,totalCrossrefCites:1,totalDimensionsCites:5,abstract:"Studying the yarn formation with the swirling air concept arouse of interest of the researchers for a long time because it appears to be easy to understand as a spinning principle. These kinds of systems are known as the vortex yarn spinning systems. The air-jet spinning methods have been developed since it is possible to eliminate the movable elements as the spindle and the traveler in ring spinning or the centrifuge in rotor spinning. The success of Murata vortex spinning (MVS) system which is the newest system after all studies of air-jet systems has been much acceptable especially for the spinning ability of 100% cotton in high speeds (500 m/min) and the yarn structure resembling ring yarn structure rather than rotor yarns. This study summarizes the historical background of vortex spinning, the spinning principle and the structure of the yarn spun on this system, as well as the factors influencing the yarn quality and finally the developments in vortex spinning technology.",book:{id:"6028",slug:"vortex-structures-in-fluid-dynamic-problems",title:"Vortex Structures in Fluid Dynamic Problems",fullTitle:"Vortex Structures in Fluid Dynamic Problems"},signatures:"Gizem Karakan Günaydin and Ali Serkan Soydan",authors:[{id:"186277",title:"Dr.",name:"Gizem",middleName:null,surname:"Karakan Günaydin",slug:"gizem-karakan-gunaydin",fullName:"Gizem Karakan Günaydin"},{id:"186607",title:"Dr.",name:"Ali",middleName:null,surname:"Serkan Soydan",slug:"ali-serkan-soydan",fullName:"Ali Serkan Soydan"}]},{id:"57228",title:"Thresholding Algorithm Optimization for Change Detection to Satellite Imagery",slug:"thresholding-algorithm-optimization-for-change-detection-to-satellite-imagery",totalDownloads:1639,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"To detect changes in satellite imagery, a supervised change detection technique was applied to Landsat images from an area in the south of México. At first, the linear regression (LR) method using the first principal component (1-PC) data, the Chi-square transformation (CST) method using first three principal component (PC-3), and tasseled cap (TC) images were applied to obtain the continuous images of change. Then, the threshold was defined by statistical parameters, and histogram secant techniques to categorize as change or unchanged the pixels. A threshold optimization iterative algorithm is proposed, based on the ground truth data and assessing the accuracy of a range of threshold values through the corresponding Kappa coefficient of concordance. Finally, to evaluate the change detection accuracy of conventional methods and the threshold optimization algorithm, 90 polygons (15,543 pixels) were sampled, categorized as real change/unchanged zones, and defined as ground truth, from the interpretation of color aerial photo slides aided by the land cover maps to obtain the omission/commission errors and the Kappa coefficient of agreement. The results show that the threshold optimization is a suitable approach that can be applied for change detection analysis.",book:{id:"6126",slug:"colorimetry-and-image-processing",title:"Colorimetry and Image Processing",fullTitle:"Colorimetry and Image Processing"},signatures:"René Vázquez-Jiménez, Rocío N. Ramos-Bernal, Raúl Romero-\nCalcerrada, Patricia Arrogante-Funes, Sulpicio Sanchez Tizapa and\nCarlos J. Novillo",authors:[{id:"213505",title:"Dr.",name:"René",middleName:null,surname:"Vázquez-Jiménez",slug:"rene-vazquez-jimenez",fullName:"René Vázquez-Jiménez"},{id:"213527",title:"Dr.",name:"Raúl",middleName:null,surname:"Romero-Calcerrada",slug:"raul-romero-calcerrada",fullName:"Raúl Romero-Calcerrada"},{id:"213529",title:"Dr.",name:"Rocío N.",middleName:null,surname:"Ramos-Bernal",slug:"rocio-n.-ramos-bernal",fullName:"Rocío N. Ramos-Bernal"},{id:"213530",title:"MSc.",name:"Patricia",middleName:null,surname:"Arrogante-Funes",slug:"patricia-arrogante-funes",fullName:"Patricia Arrogante-Funes"},{id:"213531",title:"Dr.",name:"Carlos J.",middleName:null,surname:"Novillo",slug:"carlos-j.-novillo",fullName:"Carlos J. Novillo"},{id:"221412",title:"Dr.",name:"Sulpicio",middleName:null,surname:"Sánchez-Tizapa",slug:"sulpicio-sanchez-tizapa",fullName:"Sulpicio Sánchez-Tizapa"}]},{id:"57575",title:"Colorimetry and Dichromatic Vision",slug:"colorimetry-and-dichromatic-vision",totalDownloads:1739,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Normal trichromats have three types of cone photoreceptors: L, M, and S cones (most sensitive to long, medium, or short wavelengths, respectively). Therefore, standard colorimetry is based on three variables (X, Y, Z). Dichromats only have two types of functional cones due to genetic factors. The main consequences are that dichromats (1) confuse colors that can only be discriminated by the response of the type of cone they lack and (2) make errors when naming colors. Chromaticity diagrams can be used to specify dichromats’ color confusions. Confusion points represent imaginary stimuli that only activate L, M, or S cones. Confusion lines radiate from confusion points and represent pseudoisochromatic stimuli (i.e., colors confused by the corresponding type of dichromat if presented at an appropriate intensity). Dichromat’s color appearance models have been developed to simulate the colors supposedly seen by dichromats, and there exist color simulation tools that implement some of those models.",book:{id:"6126",slug:"colorimetry-and-image-processing",title:"Colorimetry and Image Processing",fullTitle:"Colorimetry and Image Processing"},signatures:"Humberto Moreira, Leticia Álvaro, Anna Melnikova and Julio Lillo",authors:[{id:"208770",title:"Dr.",name:"Humberto",middleName:null,surname:"Moreira Villegas",slug:"humberto-moreira-villegas",fullName:"Humberto Moreira Villegas"},{id:"208826",title:"Dr.",name:"Leticia",middleName:null,surname:"Álvaro",slug:"leticia-alvaro",fullName:"Leticia Álvaro"},{id:"208827",title:"BSc.",name:"Anna",middleName:null,surname:"Melnikova",slug:"anna-melnikova",fullName:"Anna Melnikova"},{id:"208828",title:"Prof.",name:"Julio",middleName:null,surname:"Lillo",slug:"julio-lillo",fullName:"Julio Lillo"}]},{id:"31571",title:"Fluid Dynamics of Gas - Solid Fluidized Beds",slug:"fluid-dynamics-of-gas-solid-fluidized-beds",totalDownloads:10133,totalCrossrefCites:1,totalDimensionsCites:3,abstract:null,book:{id:"1013",slug:"advanced-fluid-dynamics",title:"Advanced Fluid Dynamics",fullTitle:"Advanced Fluid Dynamics"},signatures:"Germán González Silva, Natalia Prieto Jiménez and Oscar Fabio Salazar",authors:[{id:"64562",title:"Dr.",name:"German",middleName:null,surname:"Gonzalez Silva",slug:"german-gonzalez-silva",fullName:"German Gonzalez Silva"},{id:"64572",title:"MSc.",name:"Natalia",middleName:null,surname:"Prieto Jimenez",slug:"natalia-prieto-jimenez",fullName:"Natalia Prieto Jimenez"},{id:"80971",title:"MSc.",name:"Oscar Fabio",middleName:null,surname:"Salazar",slug:"oscar-fabio-salazar",fullName:"Oscar Fabio Salazar"}]}],onlineFirstChaptersFilter:{topicId:"1217",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:13,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:114,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:7,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:17,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). 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From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. 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Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:45,paginationItems:[{id:"82135",title:"Carotenoids in Cassava (Manihot esculenta Crantz)",doi:"10.5772/intechopen.105210",signatures:"Lovina I. Udoh, Josephine U. Agogbua, Eberechi R. Keyagha and Itorobong I. 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Serves as a peer reviewer for biomedical journals. Military Reserve Officer serving with the 100 Support Command, 100 Troop Command, 40 Infantry Division, CA National Guard.",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}]},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. 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