Details of first eukaryotic sequenced genome (yeast).
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7806",leadTitle:null,fullTitle:"Public Sector Crisis Management",title:"Public Sector Crisis Management",subtitle:null,reviewType:"peer-reviewed",abstract:"The term “crisis management” was applied to business only after the publication of the monograph “Crisis Management: Planning for the Inevitable” by Steven Fink in 1986. Since then, this term has turned from a journalistic cliche into a scientific concept, and its concept, theory, and methodology have been further developed.It is the turning point in the meaning of the word “crisis” that indicates the possibility of changing the situation by making decisions that contribute to changing the vector of development of events from destruction to recovery and further development. From the above, the general definition of the term “crisis management” follows as a process of saving the system from its destructive effects. The activity of the crisis manager is always temporary and stops as a result of a favorable overcoming of the crisis or vice versa—the destruction of the system. Therefore, the criterion for the success of a manager in emergency crisis management is effectiveness as an absolute measure of the presence or absence of a result—it either exists or does not exist.",isbn:"978-1-83880-982-9",printIsbn:"978-1-83880-981-2",pdfIsbn:"978-1-83880-983-6",doi:"10.5772/intechopen.77623",price:119,priceEur:129,priceUsd:155,slug:"public-sector-crisis-management",numberOfPages:174,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"84a998820880e0f006a5e9eac40d83e7",bookSignature:"Alexander Rozanov, Alexander Barannikov, Olga Belyaeva and Mikhail Smirnov",publishedDate:"October 28th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/7806.jpg",numberOfDownloads:6399,numberOfWosCitations:0,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:3,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:6,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 3rd 2019",dateEndSecondStepPublish:"December 25th 2019",dateEndThirdStepPublish:"February 23rd 2020",dateEndFourthStepPublish:"May 13th 2020",dateEndFifthStepPublish:"July 12th 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"233092",title:"Dr.",name:"Alexander",middleName:null,surname:"Rozanov",slug:"alexander-rozanov",fullName:"Alexander Rozanov",profilePictureURL:"https://mts.intechopen.com/storage/users/233092/images/system/233092.jfif",biography:"Dr. Alexander S. Rozanov is a specialist in Global Security and a graduate of Lomonosov Moscow State University (Russia). He is the author of more than 60 scientific publications. After graduating, Dr. Rozanov worked in the Russian Ministry of Foreign Affairs and the Russian Government. In 2014 he received his Ph.D. in Politics from Lomonosov Moscow State University. From 2014 to 2017, Dr. Rozanov was invited as a guest lecturer in several well-known universities – University of California, Santa Barbara (USA), Paris-Sorbonne (France), and Wroclaw University (Poland). Dr. Rozanov specializes in the analysis of global and regional conflicts, as well as the global dynamics of world development. He is a member of the European International Studies Association (Great Britain). Dr. Rozanov is an Associate Professor at the Faculty of Regional Studies and International Cooperation at the Russian Academy of National Economy and Public Administration.",institutionString:"Russian Academy of National Economy and Public Administration",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Russian Presidential Academy of National Economy and Public Administration",institutionURL:null,country:{name:"Russia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"303094",title:"Dr.",name:"Alexander",middleName:null,surname:"Barannikov",slug:"alexander-barannikov",fullName:"Alexander Barannikov",profilePictureURL:"https://mts.intechopen.com/storage/users/303094/images/system/303094.jfif",biography:"Dr. Barannikov has a PhD in Economics and Management. From 2012 to 2014, he was an independent expert of the Commission of the Federal Agency for the supply of weapons, military, special equipment and materiel on compliance with the requirements for official behavior of Federal civil servants of the Central Office of the Federal Agency. His list of scientific works includes more than 87 scientific works, including 39 inventions. Dr. Barannikov is a Professor at the Russian Academy of National Economy and Public Administration.",institutionString:"Russian Academy of National Economy and Public Administration",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:{id:"303097",title:"Dr.",name:"Olga",middleName:null,surname:"Belyaeva",slug:"olga-belyaeva",fullName:"Olga Belyaeva",profilePictureURL:"https://mts.intechopen.com/storage/users/303097/images/system/303097.jfif",biography:"Dr. Olga Belyaeva is an Associate Professor at the Russian Academy of National Economy and Public Administration at the Department of Regional Management of the Faculty of International Regional Studies and Regional Management. She has a PhD in Regional Economy. Dr. Belyaeva has 2 specialties – a professional lawyer and an economist. Dr. Belyaeva has published more than 80 scientific publications. She has been providing lectures since 2006. From 2003 to 2006 she worked in the field of audits of small and medium-sized businesses.",institutionString:"Russian Academy of National Economy and Public Administration",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorThree:{id:"308591",title:"Dr.",name:"Mikhail",middleName:null,surname:"Smirnov",slug:"mikhail-smirnov",fullName:"Mikhail Smirnov",profilePictureURL:"https://mts.intechopen.com/storage/users/308591/images/system/308591.jfif",biography:"Michael Smirnov is a Professor at the Russian Academy of National Economy and Public Administration. He has a PhD in Law. For more than 15 years, Dr. Smirnov worked as a practical lawyer in international banks and consulting companies, at the same time providing lectures at Lomonosov MSU and Russian Academy of National Economy and Public Administration. He is the author of more than 60 scientific publications. Dr. Smirnov is currently the head of the Academic Program ‘Legal Support of Financial Technologies’.",institutionString:"Russian Academy of National Economy and Public Administration",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorFour:null,coeditorFive:null,topics:[{id:"272",title:"Management",slug:"management"}],chapters:[{id:"72017",title:"Crisis Management and Communication Strategies: RUSAL’s Case",doi:"10.5772/intechopen.91644",slug:"crisis-management-and-communication-strategies-rusal-s-case",totalDownloads:638,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"No company is immune to crisis situations, an affirmation which, despite its triviality, is undeniably true. However, from the early 2014, such statement may have become even more true to Russian corporations, as the annexation of the Crimean Peninsula gave start to rounds of economic sanctions that are still perpetrated today. Such measures, which were initiated in response to the Kremlin’s political maneuvers, have hit a number of Russian companies, and increased the degree of uncertainty in which they have to operate, as they see economic restriction’s impact not only on the business activity tangible factors—i.e., economic rewards, service, and performance—but also on intangible factors—i.e., image and reputation—as well. Crises are integral parts of all world systems, unfortunately. While they are a theoretically well-understood issue, in practice, crises are perceived as a very painful phenomenon. A crisis can be compared to riding a roller coaster. First, as we gain speed and climb up the tracks we are filled with a sense of joy and delight. These feelings are quickly replaced with anticipation, panic, and fear as the roller coaster plunges into the “abyss.”",signatures:"Alexander Rozanov, Maria Ivanchenko, Alexandra Baranova, Mikhail Smirnov, Olga Belyaeva, Alexander Barannikov, Mikhail Ilichev, Ludmila Ilicheva, Biyaslan Tambiev, Maria Krotovskaya, Vladimir Chilingaryan, Tatiana Grabovich, Zaru Dulatkyzy, Alla Nikolaeva, Svetlana Ivanova, Kwame Boateng, Mattia Masolletti, Marina Danilina, Dmitry Medvedev and Natalya Ogneva",downloadPdfUrl:"/chapter/pdf-download/72017",previewPdfUrl:"/chapter/pdf-preview/72017",authors:[{id:"233092",title:"Dr.",name:"Alexander",surname:"Rozanov",slug:"alexander-rozanov",fullName:"Alexander Rozanov"},{id:"303094",title:"Dr.",name:"Alexander",surname:"Barannikov",slug:"alexander-barannikov",fullName:"Alexander Barannikov"},{id:"312160",title:null,name:"Olga",surname:"Belyaeva",slug:"olga-belyaeva",fullName:"Olga Belyaeva"},{id:"312161",title:null,name:"Mikhail",surname:"Smirnov",slug:"mikhail-smirnov",fullName:"Mikhail Smirnov"},{id:"312162",title:null,name:"Alexandra",surname:"Baranova",slug:"alexandra-baranova",fullName:"Alexandra Baranova"},{id:"312163",title:null,name:"Natalya",surname:"Ogneva",slug:"natalya-ogneva",fullName:"Natalya Ogneva"},{id:"312164",title:null,name:"Dmitry",surname:"Medvedev",slug:"dmitry-medvedev",fullName:"Dmitry Medvedev"},{id:"312165",title:null,name:"Marina",surname:"Danilina",slug:"marina-danilina",fullName:"Marina Danilina"},{id:"312197",title:"Ms.",name:"Maria",surname:"Ivanchenko",slug:"maria-ivanchenko",fullName:"Maria Ivanchenko"},{id:"316770",title:"Dr.",name:"Mattia",surname:"Masolletti",slug:"mattia-masolletti",fullName:"Mattia Masolletti"},{id:"316771",title:"Dr.",name:"Kwame",surname:"Boateng",slug:"kwame-boateng",fullName:"Kwame Boateng"},{id:"317588",title:"Dr.",name:"Svetlana",surname:"Ivanova",slug:"svetlana-ivanova",fullName:"Svetlana Ivanova"},{id:"317589",title:"Dr.",name:"Alla A.",surname:"Nikolaeva",slug:"alla-a.-nikolaeva",fullName:"Alla A. Nikolaeva"},{id:"317590",title:"Dr.",name:"Zaru",surname:"Dulatkyzy",slug:"zaru-dulatkyzy",fullName:"Zaru Dulatkyzy"},{id:"317773",title:null,name:"Tatiana",surname:"Grabovich",slug:"tatiana-grabovich",fullName:"Tatiana Grabovich"},{id:"317774",title:null,name:"Vladimir",surname:"Chilingaryan",slug:"vladimir-chilingaryan",fullName:"Vladimir Chilingaryan"},{id:"318393",title:null,name:"Maria",surname:"Krotovskaya",slug:"maria-krotovskaya",fullName:"Maria Krotovskaya"},{id:"318394",title:null,name:"Biyaslan",surname:"Tambiev",slug:"biyaslan-tambiev",fullName:"Biyaslan Tambiev"}],corrections:null},{id:"72314",title:"The Political Economy of Crisis Recovery",doi:"10.5772/intechopen.92586",slug:"the-political-economy-of-crisis-recovery",totalDownloads:589,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The aftermath of the global financial crisis marked another stress test for welfare states and varieties of capitalism. More than ever before, governments were forced to consider substantial reforms to welfare provision and enact flexibility-enhancing measures in order to improve financial solvency and economic performance. The crash, however, was not only a regionally uneven process in its origins but also led to makeshift or uneven policy responses. As a result, the socio-economic effects of the downturn and political reactions to it varied considerably among countries. Nevertheless, there have been some common trends in outcome measures. These have served to blur the dividing lines between different welfare states and production systems, so vividly captured in the mainstream political economy literature.",signatures:"Mohammad Ferdosi",downloadPdfUrl:"/chapter/pdf-download/72314",previewPdfUrl:"/chapter/pdf-preview/72314",authors:[{id:"316998",title:"Dr.",name:"Mohammad",surname:"Ferdosi",slug:"mohammad-ferdosi",fullName:"Mohammad Ferdosi"}],corrections:null},{id:"72395",title:"Contagion, Exchange Rate, and Financial Volatility: Indonesian Case in Global Financial Turbulence",doi:"10.5772/intechopen.92275",slug:"contagion-exchange-rate-and-financial-volatility-indonesian-case-in-global-financial-turbulence",totalDownloads:583,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Global turbulence after the financial crisis has hit Indonesia and almost all emerging countries. Quantitative Easing (QE) normalization (tapering of) has caused the capital outflows from emerging countries. Trade war and increasing geopolitical tension together raise the pressure. Argentina and Turkey have been experiencing economic shock. Indonesia should identify the contagion possibility and refer to Thai baht contagion experience in 1997. This paper assesses the contagion, exchange rate, and financial volatility triggered by global turbulence and Argentina-Turkey crisis in 2018. We use vector autoregression (VAR), simple correlation, dynamic conditional correlation (DCC), and regression method. We will investigate the potential contagion both in stock and exchange rate markets and in the rupiah exchange rate determination from both contagion and fundamental factors regarding the balance of payment (BOP) condition. The empirical result shows the potential contagion from Argentina and Turkey’s financial crisis to the Indonesian economy, especially to the stock market and exchange rate. The regression and correlation result also shows that Turkey has a higher financial contagion effect than Argentina to Indonesian financial market. Balance of payment condition also has the significant effect to explain rupiah exchange rate depreciation.",signatures:"Telisa Falianty and Arif Budimanta",downloadPdfUrl:"/chapter/pdf-download/72395",previewPdfUrl:"/chapter/pdf-preview/72395",authors:[{id:"317414",title:"Dr.",name:"Telisa",surname:"Falianty",slug:"telisa-falianty",fullName:"Telisa Falianty"},{id:"317419",title:"Dr.",name:"Arif",surname:"Budimanta",slug:"arif-budimanta",fullName:"Arif Budimanta"}],corrections:null},{id:"73192",title:"State Capitalism in Belarus: Behind Economic Anemia",doi:"10.5772/intechopen.93606",slug:"state-capitalism-in-belarus-behind-economic-anemia",totalDownloads:879,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Belarus’ economic model looked rather successful in the late 1990s and in the 2000s with its economic growth above 7% per year. But during the last decade, Belarusian annual economic growth has fallen at the average level around 1% per year. This chapter reveals the rarely known case of state capitalism in this post-Soviet country with its specific indicators, and instruments behind economic anemia. It also outlines several traps on the way of Belarusian economic growth: “debt trap,” “middle-income trap,” “social burden trap,” “resource curse trap,” “conflict neighbors trap,” and “forceful pressure trap.” These pitfalls lead to the long-term economic slowdown in the Republic of Belarus. The consequences of such economic anemia bring to another discussion about the role of public values in support of state capitalism in Belarus.",signatures:"Kiryl Rudy",downloadPdfUrl:"/chapter/pdf-download/73192",previewPdfUrl:"/chapter/pdf-preview/73192",authors:[{id:"323827",title:"Prof.",name:"Kiryl",surname:"Rudy",slug:"kiryl-rudy",fullName:"Kiryl Rudy"}],corrections:null},{id:"70824",title:"Crisis Management and the Public Sector: Key Trends and Perspectives",doi:"10.5772/intechopen.90855",slug:"crisis-management-and-the-public-sector-key-trends-and-perspectives",totalDownloads:1009,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"A crisis is a situation approaching a dangerous phase, which requires urgent intervention to avoid harmful effects on the body of an organization in order to return to normal situation. It is a decisive and critical time for the organization, where the wrong decision can even cost its viability. This situation can shape political, legal, economic, and governmental impact on its activities. From different definitions of crisis, we seek to underscore key elements of a crisis that may threat a public organization and, also, to highlight both the elements of management responsiveness resulting in the loss of control in the organization, regarding the short time demand for decision-making. The key purpose of this chapter is to illustrate the basis available in the international literature, upon which public risk mechanisms can be reviewed and chosen in public sector organizations under the scope of their applicability.",signatures:"Christos Lemonakis and Antonios Zairis",downloadPdfUrl:"/chapter/pdf-download/70824",previewPdfUrl:"/chapter/pdf-preview/70824",authors:[{id:"311797",title:"Dr.",name:"Christos",surname:"Lemonakis",slug:"christos-lemonakis",fullName:"Christos Lemonakis"},{id:"313069",title:"Prof.",name:"Antonios",surname:"Zairis",slug:"antonios-zairis",fullName:"Antonios Zairis"}],corrections:null},{id:"72981",title:"Applying Monte Carlo Simulation in New Tech",doi:"10.5772/intechopen.91264",slug:"applying-monte-carlo-simulation-in-new-tech",totalDownloads:371,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Monte Carlo in Monaco is given to the theory for mathematics, whose simulation process involves generating chance variables and exhibiting random behaviours in nature. This simulation is a powerful statistical analysis tool and widely used in both non-engineering fields and engineering fields for new perspectives. This simulation has been applied to diverse problems ranging from the simulation of complex physical phenomena such as atom collisions, to the simulation of river boundary layers as meanders and Dow Jones forecasting. It can deal with many random variables, various distribution types and highly nonlinear engineering models, while Monte Carlo is also suitable for solving complex engineering problems in two areas which are varying randomly. Monte Carlo simulation is given as an application for hydrogen energy potential determination.",signatures:"Levent Yilmaz",downloadPdfUrl:"/chapter/pdf-download/72981",previewPdfUrl:"/chapter/pdf-preview/72981",authors:[{id:"305285",title:"Prof.",name:"Levent",surname:"Yilmaz",slug:"levent-yilmaz",fullName:"Levent Yilmaz"}],corrections:null},{id:"71352",title:"Management of Tourism Crisis in the Middle East",doi:"10.5772/intechopen.90174",slug:"management-of-tourism-crisis-in-the-middle-east",totalDownloads:650,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This study looks for to recognize the realism of management of tourism crisis in Jordan (Amman Hotels’ Bombing case study). In order to show the role of the management and its effects in facing the tourism crisis in Jordan, the researcher will try to handle a group of points: finding a special concept for tourism crisis, crisis generative environment, management of tourism crisis, and studying Jordan management of the Hotel bombing in Amman. To clarify and achieve the objectives of the research, the researcher adopted the descriptive analytical approach to what is stated in the most important books and references Arab and foreign periodicals, statistics, and official reports relating to the ethics of the research. It is recommended, in this study, to provide training opportunities for all people who have a role in the management of tourism crisis especially in the communication sector, the massive presence of police in the tourism site, hotels, and all the tourism places under the condition of not being seen, and to provide the qualified policemen with modern defensive weapons.",signatures:"Omar Jawabreh",downloadPdfUrl:"/chapter/pdf-download/71352",previewPdfUrl:"/chapter/pdf-preview/71352",authors:[{id:"311791",title:"Associate Prof.",name:"Omar",surname:"Jawabreh",slug:"omar-jawabreh",fullName:"Omar Jawabreh"}],corrections:null},{id:"70464",title:"Exploring the Three-Way Destination Safety Solution to Crisis Management in Tourist Destinations in Rural Nigeria",doi:"10.5772/intechopen.89727",slug:"exploring-the-three-way-destination-safety-solution-to-crisis-management-in-tourist-destinations-in-",totalDownloads:616,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Development of tourist destinations is among topical issues in national discourse for economic growth and sustainability. The past two decades have witnessed massive development and investment in tourist destinations in rural areas. This is owing to the fact that rural tourism has been identified as among the development options for rural communities in most developing nations. Of recent, crisis and other safety issues have been among the militating factors against tourist destinations hence the cry for destination safety. These are said to emanate from the activities of the three major principals in the management of tourist destinations (hosts, tourism resources, and tourists/visitors). Incidentally, destination safety discourse is source of worry for these principal factors in tourist destination management. This has left many tourist destinations devastated, abandoned and abused. However, this chapter proposal would seek to identify the way out of this predicament. It tends to explore the meaning and application of the three-way destination safety (TWaDeSS) model in the management of crisis at tourist destinations in rural Nigeria. This will not only promote harmony among the three major principals in tourist destination but also enhance the rate of investment as a result of quality crisis control in these destinations.",signatures:"Elochukwu A. Nwankwo",downloadPdfUrl:"/chapter/pdf-download/70464",previewPdfUrl:"/chapter/pdf-preview/70464",authors:[{id:"308906",title:"Dr.",name:"Elochukwu",surname:"Nwankwo",slug:"elochukwu-nwankwo",fullName:"Elochukwu Nwankwo"}],corrections:null},{id:"69310",title:"Crisis Management in Nigeria’s Public Sector and the Impact of the Organised Labour Union: Interrogating the Nexus between Industrial Harmony and Political Stability",doi:"10.5772/intechopen.89562",slug:"crisis-management-in-nigeria-s-public-sector-and-the-impact-of-the-organised-labour-union-interrogat",totalDownloads:450,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"This study sought to explore the dynamics in managing crisis in the Nigerian public sector and its engagement with the organised labour, with a view to determining the interface between industrial harmony and political stability in the country. This study is predicated on the fact that crisis management is essentially embedded in humanity. Additionally, the study was informed by the established and widely held view by scholars, that social groups by their nature and context, are in fact characterised by conflicts. Consequently, the study established that the public sector in every society is not immune against conflict or crisis, and this will naturally arise as long as there is interaction between and among human elements in the two sectors. The author used the terms—crisis and conflict—interchangeably in the study, and pointed out that the methodology adopted was a descriptive and analytical approach. This is informed by the sources of information accessed which are essentially secondary. The study concluded by asserting that given the humanity-linked nature of conflict, its management in the public sector, particularly in Nigeria, will continue to be an unavoidable responsibility of the government. This is to ensure that the right environment is created to guarantee smooth governance.",signatures:"Daniel Taye Medoye",downloadPdfUrl:"/chapter/pdf-download/69310",previewPdfUrl:"/chapter/pdf-preview/69310",authors:[{id:"308852",title:"Dr.",name:"Daniel Taye",surname:"Medoye",slug:"daniel-taye-medoye",fullName:"Daniel Taye Medoye"}],corrections:null},{id:"71859",title:"The Police Development and Protection of Soft Targets",doi:"10.5772/intechopen.92072",slug:"the-police-development-and-protection-of-soft-targets",totalDownloads:614,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This paper describes the function and development of the requirements for modern and high-quality equipment and accessories and also equipment used by the specialized units of the police force of the ČR with a practical example. This is offered in the form of a draft requirement for a transport means – a multifunctional special vehicle, intended specifically to intervene in situations against demonstrators, extremists, and football hooligans. 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Kasai",coverURL:"https://cdn.intechopen.com/books/images_new/7552.jpg",editedByType:"Edited by",editors:[{id:"29226",title:"Dr.",name:"Minobu",surname:"Kasai",slug:"minobu-kasai",fullName:"Minobu Kasai"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10896",title:"Integrative Advances in Rice Research",subtitle:null,isOpenForSubmission:!1,hash:"47659401ffe512c28313440110c0a903",slug:"integrative-advances-in-rice-research",bookSignature:"Min Huang",coverURL:"https://cdn.intechopen.com/books/images_new/10896.jpg",editedByType:"Edited by",editors:[{id:"189829",title:"Dr.",name:"Min",surname:"Huang",slug:"min-huang",fullName:"Min Huang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"64889",title:"Common Methods to Understand and Develop Indigenous Probiotics Yeast for Ruminant",doi:"10.5772/intechopen.82731",slug:"common-methods-to-understand-and-develop-indigenous-probiotics-yeast-for-ruminant",body:'Over the past decades, the livestock industry has been revolutionized toward the use of microbial feed additives due to an increasing awareness of the stockholders on the beneficial role of probiotics in production and gut health status [1, 2]. There are several probiotic products that are commercially available and marketed for animal use [3]. Most probiotic products at the moment do not go through pre-market approvals and are commonly used for a much wider range of scenarios in which their efficacy is not well established. Similarly, latest molecular methods such as gene sequencing and phylogenetic analysis are not used to identify the probiotic strains as feed supplements. For the selection of best probiotic product, it is highly important to determine the real probiotic potential of the microbial strain by using latest molecular methods. In this contract, locally isolated and validated probiotic strains will be better than any unauthorized local available strain. The competitive advantage and adaptability to local microbial ecosystem will allow local probiotic strain to grow and adhere well in the local animal breed. Literature showed that probiotic strains should specifically prepare according to purpose and function related to the milk enhancement in local breed [4, 5]. Nowadays, it is highly accepted that probiotic yeast is highly productive in terms of milk and meat for large animals [6, 7]. Probiotic yeast improves the ruminal gut microbiota which may increase the nutrient digestibility and leads to improve animal productivity [8]. In large animals, ingested feed digested by numerous microbial species is present along the gastrointestinal tract [9]. This microbial community consists of 1014 members, mainly composed of fibrolytic bacterial species [10]. Literature highlighted that gut microbiota plays important role in the feed digestion and utilization. The gut microbial populations in cow have been identified in almost 90% of the total microbial community [11]. On the other hand, a certain fraction of the GI tract bacterial community has yet to be identified due to less knowledge of the microbial community in gut microbial ecosystem because majority of the 16S rRNA gene sequences from feces are taken from unidentified species, and many modern methods of genomic analysis of communities to determine changes in microbiota have been used by many scientists [12]. Studies have utilized culture-independent sequencing techniques, 16S rDNA bacterial tag-encoded FLX amplicon pyrosequencing and many more have added a new era to determine the microbial diversity of the GI tract [13]. Research noted that the culture-independent methods deliver a comprehensive assessment of the microbial community composition, while the culture-dependent methods provide the structural and functional diversity of the microbial strains [14]. In this chapter, a detailed discussion on the effects of probiotic yeast in ruminant’s well being, production performance, uses of different omics methodologies for the discovery of ideal animal probiotic strains and development of indigenous probiotic yeast for ruminant will be employed.
The
Yeast genome | |
---|---|
Genome size | 12.1 Mb |
Chromosomes | 16 |
Genes | 5300–5400 |
Base pairs | 12 million base pairs |
Databases | SGD, MIPS, YPD |
Details of first eukaryotic sequenced genome (yeast).
Ruminant nutritionists have been pondering to improvise new methodologies for ameliorating the roles of microflora in ruminants and enhance processes of digestion and fermentation along with augmented nutrients usage and bioavailability using feed supplementation. One of the commonly used methods was the use of growth promoters (antibiotics) to restrict the pathogenic effect on productivity of ruminants [16]. Nevertheless, antibiotics have been reported to cause serious health challenges to consumers and environmental implications. Thus, their usage has been banned in 2006 due to emerging antibiotic resistance. In the light of these concerns, consumer preferred more natural product. A super alternate of feed additives was the use of probiotics [17]. Probiotics are living microorganisms confined in animal feed that affect the host by improving the digestion [18]. Other definition includes probiotics as microorganisms (viable) that functions in gaining weight and feed conversions along with reducing diarrheal incidence [19]. Probiotics have been deployed as one of the recent exploited proposals in ensuring efficiency of production systems and safety to both consumers and environment [20, 21]. In ruminant nutrition, yeast probiotics are commonly being used because of their efficient roles in rumen stabilization and maintaining microbial communities specifically fibrolytic bacteria [22]. The yeast cells function in maintaining throughout viability of the digestive tract [23]. Yeast supplementation as probiotics enhanced feed conversion, efficient fermentation, and fiber digestion in the rumen, maintained ruminal pH, increased milk production [24, 25] and feed intake and production of organic acids and vitamins to activate the growth of the lactic acid bacteria (LAB) [26]. The commonly used yeast probiotic is
Rumen microbial manipulation by using the probiotics to improve the ruminant feed digestion is a promising production improvement strategy. A better understanding of the rumen microbiology is an important step to select and prepare a new yeast strain affecting on functional specific microbes. Latest molecular techniques have provided the opportunity to study the rumen microbiota in detail for development of the ideal probiotic.
Digestive system of ruminant is composed of four parts: reticulum, rumen, omasum and abomasums. The rumen is that part of the digestive system in which fermentation is carried out [30]. The rumen can also be defined as a complex ecosystem in which nutrients consumed by different microorganisms are digested anaerobically. Microbial biomass and volatile fatty acids are most common end products of fermentation which are then used by ruminant host. Interaction of host animal and microorganisms is a symbiotic relationship that helps the ruminant hosts in digestion of fiber-rich and protein-low diets. Rumen microorganisms provide enzymes that are necessary for fermentation processes, which in turn allow ruminants to obtain energy contained in forage [31]. Growth and activity of ruminal microorganisms are influenced by different factors including pH, temperature, osmotic pressure, buffering capacity, and redox potential. These factors are determined by environmental factors. Temperature of the rumen is in the range of 39–39.5°C. But when animal eats, fermentation occurs that generates heat due to which temperature increases up to the limit of 41°C [32, 33]. Short-chain fatty acid generation along with their absorption, saliva production, feed intake level and type, as well as exchange of phosphates and bicarbonates through epithelium of the rumen are the factors that affect pH [34]. In the reticule ruminal environment, these factors determine the buffering capacity as well as pH. There is a constant change in pH but mostly it remains in the range of 5.5–7.0 [35]. When there is an acidic environment in the cell, bacterial intracellular pH decreases. Microbial enzymes are very much sensitive to pH, i.e., bacterial growth is inhibited when there is an acidic pH. This is due to the disproportion of intracellular hydrogen ions [36]. In the rumen, ions and molecules affect osmotic pressure due to which gas tension is created. Fermentation process in the rumen depends upon the environmental factors and the diet due to which these factors also affect rumen osmotic pressure [37] (Figure 1).
Rumen ecosystem: different types of microbial flora present inside the rumen. The most abundant microbes are bacteria.
Bacteria are more in number than any other microbes. It is noted that there are five groups of rumen bacteria: (1) free-living in liquid phase, (2) loosely attached with feed, (3) firmly attached with feed, (4) attached with rumen epithelial lining, and (5) attached with protozoa/fungi. The bacterial species inside the rumen are 99.5% obligatory anaerobic. Mostly rumen bacteria are involved in the fermentation of fibers, starch, and sugar present in the feed and converted into volatile fatty acid, H2, and CO2 [38]. Most of the bacteria are responsible for degradation of different types of dietary components [39] (Table 2).
Bacteria | Species |
---|---|
Carbohydrate-utilizing bacteria | |
Nitrogen-utilizing bacteria | |
Lipid-utilizing bacteria |
Bacterial diversity of the rumen microbial ecosystem.
Majority of anaerobic rumen fungi is from order
Microbial species | Rumen | Fecal |
---|---|---|
Bacteria | ||
Fungi | ||
Archaea |
Bacteria, fungi, and archaea present inside the rumen and feces of dairy cows.
The rumen is the first part of the ruminant stomach which has a well-developed microbial ecosystem containing different types of microbes (bacteria, fungi, protozoa, and bacteriophages). These microbes coexist in ecological equilibrium in unique symbiotic relationship between cows and rumen microbes. The cows supply food to the rumen microbes which in turn digest the feedstuff to provide cows the essential nutrients in the form of microbial protein as organic acid energy sources. The microscopic view of rumen ecosystem showed that it is consisted of a number of bacteria, protozoa and fungi [42]. Bacteria make the largest population in this diverse microbial world. Their function is to digest the fibers, starch, sugar acids, and protein to give useful compounds and elements necessary for the growth and productivity of the cows. The role of protozoa and fungi is less clear. However, these microbes do provide help in digestion of feed. The structure and function of microbial community are influenced by feed composition and mainly by the host genetic potential.
Representative scheme of effect of live yeast on the microbial flora of the gastrointestinal tract in ruminants: live yeast improves carbohydrate, protein, and lipid digestion rates by improving the production of cellulolytic, hemi-cellulolytic, and proteolytic and lipolytic bacteria and fungi.
Better conditions have been created by this change for the growth of anaerobic cellulolytic bacteria which in turn stimulates their attachment to forage particles as well as increases the initial rate of cellulolysis. Recalcitrant plant lignocellulosic material is not degraded by ruminants on its own. They rely on rumen microbial flora for its degradation [48]. The main components of the fiber are cellulose, hemicellulose, and lignin. It has been estimated that 20–70% of the ruminant feed is composed of the cellulose and hemicellulose [49]. The most abundant carbohydrate in plant cell wall is the cellulose which makes up to 40% of the plant cell wall. The microbial cellulolytic enzymes have the capability to digest the β-1,4 links present inside the cellulose, glucose molecules [50] (Figure 3).
A scheme describing the mode of action of yeast culture: improved the gut microbial balance is related to the O2 slavering by live yeast cells.
The lower gut microbial population is affected by dietary supplementation of the probiotic yeast. The probiotics provide a desirable microbial balance due to shift in the balance of friendly and pathogenic microbiota. The GIT having healthy microbial populations are often related with improved host performance and its immune system. In the lower gut, the pathogenic microbial species reduces due to the production of the antimicrobial material (bacteriocin) and the attachment of the friendly microbes to the gut wall, via the competitive exclusive method. The most common modulation of the GIT microflora is provided by probiotics [51].
Latest researches have improved our understanding related to the mode of action of probiotic yeast inside the rumen. Well-designed animal studies have verified that target-specific probiotic strains have health and production benefits in the ruminants. These studies have made the livestock industry to accept and understand the probiotic concept [52]. On the other hand, current probiotic has not been chosen for definite purposes in the animal feed. Therefore, some unique molecular methods are needed for selection and characterization of target-specific probiotic strains [53]. It has been noted that during stress conditions, some portion of the live probiotic microbial strain enters in the dormant but metabolically active state called viable but nonculturable (VBNC) state. These microbial cells have an ability to replicate when acclimated to a favorable condition inside the host [54]. Uses of molecular techniques have changed the study of the rumen ecosystem. First is the PCR which is more sensitive than growth on traditional selective media in determining small differences in population sizes in response to dietary changes or upon the inclusion of an additive to the diet and thus may identify changes or shifts within levels of the microbial population which may have been previously overlooked [55] (Figure 4).
Probiotic preparation: general steps for the isolation and characterization of probiotic yeast strains for local animal breed.
In response to various feeding sources, changes within the microbial population can be studied by DNA fingerprinting (DGGE, TTGE, and TGGE). Probiotic can be classified into three different types, like mono-probiotic, poly probiotics, and combined probiotics depending on the probiotic strain function [55] (Figure 5).
Potential characteristics of typical animal probiotic yeast.
Yeasts and fungi are the ideal organisms and have been used in vast genetic studies and comparative genomic studies in eukaryotes because of their small and compact genomes.
We have sketched sampling approaches and finalized the protocols that will guide researchers in identifying the most ideal probiotics for animal use. Livestock is under increasing threat of antimicrobial resistance genes; therefore, continued optimization of protocols is urgently needed so that these threats can be reduced through the use of probiotics. Two sequence-based methods are commonly used for the identification of yeast. The first and the most common method used for the identification is PCR amplification of internal transcribed spacer (ITS) of nuclear ribosomal variable region that has been recognized as the universal barcode for the identification of fungi. The second and the advanced approach to identify fungal species or strains is shotgun metagenomics [56]. Microbes are very vital to life present on the earth. Their significance is increasing day by day as their beneficiary potential has been recognized in the field of health and medicine. There are two methods which have been utilized till now for the identification of the microorganisms present in microbial community.
Culture-dependent method
Culture-independent method
Both approaches have their own significance. Culture-based methods are considered effective for the morphological, physiological, and functional characterizations of a particular strain, while culture-independent technology is preferred to unravel the microbial diversity along with genomic and genetic identification of microbial communities. Studies have also indicated that there is a loss of 99% microbes in the laboratory-dependent culturing methods. Culturing-independent method has been recognized as an effective and efficient method to isolate the DNA of a number of microbes from an environmental sample which seems impossible using the cultural methods. The linkage of culture-dependent and culture-independent data has been recognized as a crucial step for the identification of probiotics [57]. For identification of the potential probiotic strains, researchers should use the latest molecular methods, and the probiotic strains should be deposited in some recognized microbial culture collection. Proteomics and metabolomics may also be used for choosing the best yeast species [58]. By utilizing strain’s proteome and metabolome, which are argued to yield a positive influence upon ruminal fermentation, it may be possible to identify specific traits, characteristics, and secondary growth metabolites that play a potential role to enhance the growth of target-specific microorganisms inside the rumen. Even accounting for the potential bias of latest molecular methods, it is obvious that these methods are the dominant tools recently accessible for monitoring the gut for bacterial diversity of dairy animals and developing new yeast strain [59]. Extensive use of molecular methodologies may give insights into the new era where such microbial studies are no longer limited to a handful of laboratories with an abundance of funding and labor. It is noted that the specific yeast strains of known origin act more precisely and efficiently as compared to the yeast strain obtained from any unknown origin [60]. As we note all ruminates live in different parts of the world; therefore, upon the ruminal fermentation different yeast strains may exhibit markedly different effects. Therefore, we should identify new yeast strains for getting best results on the rumen fermentation. Uses of molecular techniques have changed the study of the rumen ecosystem. First is the PCR which is more sensitive than growth on traditional selective media in determining small differences in population sizes in response to dietary changes or upon the inclusion of an additive to the diet and thus may identify changes or shifts within levels of the microbial population which may have been previously overlooked. In response to various feeding sources, changes within the microbial population can be studied by DNA fingerprinting (DGGE, TTGE, and TGGE). To select best yeast strains, proteomics and metabolomics may also be used. By characterizing the proteome and metabolome of microbial isolates endowed with the ability to have a positive impact on the rumen fermentation, it may be possible to identify specific traits, characteristics, and secondary growth metabolites which play genuine role in the improvement of the growth of some important microbial species [61] (Figure 6).
Interlinked factors involved in the application of probiotic in the ruminant nutrition.
Cultural approach is the widely used method in microbiology to grow a microbe in a laboratory. Sampling is the basic and the crucial step for the identification of the indigenous probiotic yeast. The second step is isolation of the pure yeast strain under laboratory conditions which requires a series of inoculation steps of the microbes on the selective media. After purification of the yeast isolate on the OGA media, the biochemical tests are performed to identify the distinct features of the pure isolates. Morphological features of the isolate are determined by using electron microscope. The next step is the molecular identification of the yeast via 18S rRNA gene sequencing. The probiotic characterization is usually performed according to the standards defined by the WHO [62]. The best probiotic strain is retrieved among all the selected potential candidates, and in vivo experiments are performed using an animal model. After functional testing, all technological and safety measures are accessed, and the probiotic yeast strain is ready for probiotic product and packaging [63].
The use of omics approach has been emphasized to study the microbiome of microbes. To identify the potential probiotic strains among the microbial community present in any environment, it is very important to identify all the microorganisms in microbiota and determine their structural and functional differences at genomic level. Below are the currently available omics approaches for the identification, screening, and selection of probiotic strains of indigenous yeast [64] (Figure 7).
Omics approaches to identify the probiotic.
Amplicon sequencing refers to the sequencing of a specific fragment of interest of a microbe using high-throughput sequencing technique. 18S amplicon sequencing is specifically used to determine the most prevalent fungal yeast species present in microbiota [65]. The methodologies used in the recent researches for the identification of bacterial probiotics can be applied in the recognition of indigenous probiotic yeast strains. The comparative and detailed analysis of 18S amplicon sequencing data can help the scientists in the isolation of potential probiotic after the identification of functional and structural characteristics of the indigenous yeast in microbiota. Further experiments and testing would be required to maximize the production and ability of probiotic yeast in the gut of an animal [66]. Furthermore, the 18S amplicon sequencing does not only help in the indigenous yeast identification, but it also reveals the diversity of microeukaryotes when 18S rRNA gene is sequenced [67].
Shotgun metagenomics is one of the most advanced techniques of sequencing in which the entire microbiome of microbiota is sequenced. The data generated using this method provides all the information about the genome of an organism [68]. Metagenomics information unravels the composition of microbial community and also indicates the genes, their functions, and associated genetic pathways. The identification of the indigenous yeast and their probiotic potential and capabilities can also be determined using the metagenomics data. Their relationship within the microbial community and their effect on the host can also be studied on the basis of the retrieved information [69].
Scientists and researchers are using metatrancriptomics to study and analyze the expression profiles of mRNA in a microbial community. The identification of genes, genetic pathways and their regulation, host-microbe interaction, and the symbiotic relation among microbes can easily be determined by using the mRNA expression data. Metatranscriptome approach can be pursued in the identification of indigenous probiotic yeast within the microbiota of an animal. For this purpose the sampling methods and molecular techniques should be improved [70].
Metabolomics refers to the study of the metabolites or final cellular products. This is also considered one of the useful and efficient methods for the identification of probiotic potential of a microorganism within a microbiota of an animal or selected biological sample [71]. Indigenous probiotic potential of yeast can also be determined using this technique. Studies are still needed to fully understand the function of metabolites in context of probiotic potential and other inhibitory functions of metabolic compounds. As metabolites vary in structure and function, so they could be used in the comparative studies of species and populations. A number of species with high probiotic potential could be approached using metabolomics [72].
Yeast probiotics not only help to improve the performance factor of cattle, but it also enhances nutrient digestibility. However, the effectiveness of yeast-supplemented products is variable. Therefore, future studies are required to estimate the potency of these diet products as supplements for finishing beef cattle, with an objective to have healthier and productive animals without negotiating their efficiency and costs.
The animal body is a “supraorganism” and refers to the gastrointestinal tract as a virtual organ of the human body. The ongoing research is mainly on probiotics that are used chiefly for the GI tract, whereas there is an impetus need to evaluate the progress on other regions of the body as well.
Yeast supplementation is an effective strategy; thus, it is vital to ensure the stability and viability of yeast-supplemented diet products by developing practicable and cost-effective technologies (e.g., storage, microencapsulation, etc.), which poses marketing and technological challenges for producers at industrial level. Polysaccharides, lipids, and proteins are chiefly used for encapsulation materials in food industry. However, cost-effective production remains a challenge for production of future probiotics and formulation technologies.
Role of yeast probiotics in combating antibiotic-associated diseases has been extensively reported through control trials and ingestion of yeast probiotics (
There is a dire need to understand the composition and relationship of microbial community within an animal gut for improving the production of dairy products. Advances in the high-throughput technologies, computational tools, and omics approaches give insights into the molecular and genetic potential of an organism. Studies in the omics arena are still needed to fully understand the genetic mechanisms and pathway analysis.
Every living organism is different in terms of their genetic makeup. The current progresses in sequencing and functional omics techniques have delivered better understandings into the precise mechanisms underlying probiotic functionality. The emerging understanding of the animal gut microbiota allowed accurate characterization of probiotic effects on the commensal microbiota of animal in vivo. Identification of genes vital to probiotic functionality is providing scientists the capacity to genetically tailor probiotics to encounter the requirements for precise applications. The livestock sector has a larger proportion of land consumption than agriculture keeping in view both grain feed intake and grazing. This trend is expected to rise, putting pressure and competencies on land resources in the agriculture sector. Moreover, there is a high demand for quality production which Cannot be attained by traditional practices for feeding ruminants. Quality cereal feed costs high and is uneconomical for large production. Consequently, this creates an imbalance in nutrition which drastically reduces dairy production. Probiotic yeast can overcome dairy production disparity. It augments nutrient uptake and increases Immunity, overall better health and production. Utilization of probiotic yeast for health and production is influenced by many different factors including probiotic strains, age, and breed of cattle. Essentially, yeast probiotics enhance assimilation by balancing the microflora of the rumen. It facilitates fiber digestion via inducing fermentation and stabilizing high pH. Facilitating an environment that flourishes rumen microbes is one factor. Other avenues need to be explored for probiotic yeast. More probiotic yeast strains are needed to be identified. For the preparation of probiotic feed, a complete nutritional profile generation is required. Furthermore, the amino acid profile of milk produced by dairy heifers fed on yeast probiotic should be analyzed.
The recommendations are outlined as follows:
Sampling source should be indigenous for isolation of the probiotic strains.
The identification of the probiotic strains must be based on the international validated molecular methods.
The identified strain name should be deposited in validated microbial culture collection.
The probiotic as well as genetic properties of the probiotic strains should be studied. Good manufacturing practices must be applied with quality assurance and shelf-life conditions established and labeling made clear to include minimum dosage and verifiable health claims.
Oceanic islands are those that never had a connection to continental land masses, being generally composed of volcanic rock, reef limestone or both. Those of volcanic origin are formed over oceanic plates, being a product of volcanism or tectonic uplift. These islands tend to be steep and relatively high for their area and, over time, become highly sheared due to erosion processes. Usually, they lack native mammals and amphibians, but a fair number of birds and insects, as some reptiles are usually present [1]. Not classified as “real” islands, atolls and reef are marine habitats islands, built up by small coelenterate animals (corals) that secrete a calcareous exoskeleton. These form an annular reef rim surrounding a central lagoon, with the rim being more or less occupied by calcareous sand or coral shingle and rubble [2], such as the reef islands of the Maldives, the Solomon Islands, the Bahamas, the Tarawa atoll in Kiribati, and many other islands and atolls in the Pacific Ocean. Coral islands tend to be very low-lying and flat; some only raised a few meters above sea level [1]. As defined by Paulay [3] all these are considered oceanic islands (Figure 1a and b).
Examples of oceanic islands: left: S. Miguel, one of the nine islands of the Azores volcanic archipelago; right: an atoll at the Maldives, one of the 1192 coral islands that are grouped in 26 atolls.
Oceanic island are mainly small islands, which are defined as those which present less than 10,000 km2 [4]. The largest oceanic island on Earth is Iceland, with more than 100 thousand square kilometres, but all the other oceanic island are much smaller, being New Britain (Papua New Guinea), Grande Terre (New Caledonia), Negros (Philippines), and Hawaii (USA), the other large oceanic islands.
Besides these, there are millions of small islands and islets. Table 1 states these small oceanic islands and oceanic archipelagos throughout the globe, being referred the main island of the archipelago (if any), the size, and the location. To avoid being over-exhaustive in this analysis, only the main oceanic island of each archipelago is presented, in addition to the isolated islands.
Main island | Is. area [km2] | Archipelago (Ac) | Ac area [km2] | Country | Ocean | Coordinates |
---|---|---|---|---|---|---|
Iceland | 102,775 | Iceland | Arctic | 64°08′N 21°56′W | ||
Santorini | 73 | Cyclades | 2,572 | Greece | Mediterranean | 36° 23′ N 25° 27′ E |
Lipari | 37 | Aeolian Islands | 115 | Italy | Mediterranean | 38°28′N 14°57′E |
S. Miguel | 759 | Azores | 2,351 | Portugal | North Atlantic | 37°44′28″N 25°40′50″W |
Tenerife | 2,034 | Canary Islands | 7,493 | Spain | Northeast Atlantic | 28°28′N 16°15′W |
Santiago | 991 | Cape Verde | 4,033 | Cape Verde | Northeast Atlantic | 14°55′N 23°31′W |
Madeira | 740 | Madeira | 801 | Portugal | Northeast Atlantic | 32°39′N 16°55′W |
Bermuda | 53 | The Somers Isles | UK | Northwest Atlantic | 32°18′N 64°47′W | |
New Providence | 207 | Bahamas | 13,878 | Bahamas | West Indies, Atlantic | 25°4′N 77°20′W |
Fernando Noronha | 18 | Atlantic Islands | 26 | Brazil | Southwest Atlantic | 3°51′13″S 32°25′25″W |
Montague | 120 | South Sandwich Islands | 3,903 | UK | South Atlantic | 58°25′S 26°23′W |
Tristan da Cunha | 96 | Tristan da Cunha Islands | 207 | UK | South Atlantic | 37°4′S 12°19′W |
Heard | 368 | Heard Isl. & McDonald Isls. | 371 | Australia | Atlantic (Antarctic) | 53°06′S 73°31′E |
La Grande Terre | 6,675 | Kerguelen Islands | 7215 | France | Atlantic (Subantarctic) | 49°20′55″S 70°13′09″E |
Île de la Possession | 67 | Crozet Islands | 352 | France | Atlantic (Subantarctic) | 46°24′S 51°46′E |
Bouvet | 49 | Norway | Atlantic (Subantarctic) | 54°25′S 3°22′E | ||
Guadeloupe | 1,628 | Antilles volcanic arc | 14,364 | France | Caribbean Sea, Atlantic | 16°02′04″N 61°41′56″W |
Grande Comoro | 1,147 | Comoros Islands | 1,861 | Comoros | Western Indian | 11.699°S 43.256°E |
La Réunion | 2,511 | France | Western Indian | 21°06′52″S 55°31′57″E | ||
Malé | 8 | Maldives | 300 | Maldives | Indian | 4°10′31″N 73°30′32″E |
Diego Garcia | 30 | UK | Indian | 7°18′48′′S 72°24′40′′E | ||
St. Paul | 6 | France | Indian | 38°43′S 77°13′E | ||
Unimak | 4,070 | Aleutians | 17,670 | Russia/USA | North Pacific | 52°02′N 174°02′W |
Iturup | 3,139 | Kuril Islands | 10,503 | Japan, Russia | Northwest Pacific Ocean | 45°02′N 147°37′E |
Hokkaido | 378 | Japanese | 83,424 | Japan | Northwest Pacific | 43°4′N 141°21′E |
Tidore | 1,550 | Moluccas Islands | 74,505 | Indonesia | Western Pacific | 0°41′N 127°24′E |
Negros | 13,350 | Visayas | 71,503 | Philippines | Western Pacific | 10°40′35″N 122°57′03″E |
New Britain | 36,520 | Bismarck | 49,700 | Papua-New Guinea | Western Pacific | 5°44′S 150°44′E |
Bougainville Island | 9,318 | Solomon Islands | 28,400 | Papua-New Guinea | Melanesia, Pacific | 6°14′40″S 155°23′02″E |
Espiritu Santo | 3,955 | New Hebrides | 12,189 | Vanuatu | Melanesia, South Pacific | 17°44′S 168°19′E |
Grande Terre | 16,372 | New Caledonia | 18,576 | France | Melanesia, South Pacific | 22°16′S 166°28′E |
Tarawa | 31 | Kiribati | 811 | Kiribati | Micronesia, Pacific | 1°28′N 173°2′E |
Majuro | 10 | Marshall Islands | 181 | Marshall Islands | Micronesia, Pacific | 7°7′N 171°4′E |
Guam | 540 | Mariana Islands | 1,036 | USA | Micronesia, Pacific | 16°37′N 145°37′E |
Hawaii | 10,432 | Hawaiian | 28,311 | USA | Polynesia, Pacific | 19°34′N 155°30′W |
Savai’i | 1,694 | Samoa | 2,842 | Samoa | Polynesia, Pacific | 13°50′S 171°45′W |
Vaitupu | 6 | Ellice Islands | 26 | Tuvalu | Polynesia, Pacific | 07°28′S 178°41′E |
Nuku Hiva | 339 | Marquesas Islands | 1,049 | France | Polynesia, Pacific | 8°52′S 140°08′W |
Tahiti | 1,044 | Society islands | 1,590 | Tahiti | Polynesia, Pacific | 17°40′S 149°25′W |
Tongatapu | 260 | Tonga Islands | 750 | Tonga | Polynesia, Pacific | 21°08′S 175°12′W |
Rarotonga | 67 | Cook Islands | 237 | Cook Islands | Polynesia, Pacific | 21.235°S 159.778°W |
Tubual | 45 | Austral islands | 152 | France | Polynesia, Pacific | 23°22′12″S 149°28′48″W |
Henderson Island | 37 | Pitcairn Islands | 47 | UK | Polynesia, Pacific | 24°22′01″S 128°18′57″W |
Isabela | 4,586 | Galápagos Islands | 7,880 | Equator | East Pacific | 0°30′S 90°30′W |
Socorro | 132 | Revillagigedo | 158 | Mexico | East Pacific | 18°50′N 112°50′W |
San Ambrosio | 3 | San Félix Islands | 5.36 | Chile | East Pacific | 26°20′37″S 79°53′28″W |
Easter Island | 164 | Chile | East Pacific | 27°7′S 109°22′W | ||
Selkirk | 50 | Juan Fernández Islands | 100 | Chile | East Pacific | 33°45′04″S 80°47′00″W |
Auckland | 443 | Auckland islands | 626 | New Zealand | South Pacific | 50.7°S 166.1°E |
Main oceanic islands, including the archipelago, the country, the ocean, the island and the archipelago total area, and the coordinates of the main city.
In contrast to oceanic islands, continental islands were joined to continental land in the past, namely during the Quaternary ice ages, and becoming separated owing to sea level rise or to tectonic events, and still sit on the continental shelf. As such such, terrestrial mammals and amphibians are usually present [1, 3]. Most of the larger islands are of continental origin, such as Greenland, New Guinea, Borneo, Madagascar, Baffin Island, Sumatra, Honshu, Victoria Island, or Great Britain.
Oceanic islands are usually smaller, younger, more isolated from the continent, more isolated from the nearest neighbour island and present less plant species than continental islands [5]. Their climate has, evidently, a strong oceanic influence, with the low islands being much drier and the high islands presenting heavy orographic rainfall. Most oceanic islands have freshwater reservoirs, both volcanic and atolls, which depend on rainfall percolating through the island. Small islets, however, may lack such lens, being therefore adverse for plant growth [1].
When a new island emerges, an ecological succession begins with the species that were able to reach the land colonising the island but subjected to island isolation. High dispersal capabilities are more likely to overcome distance, which determines that plants, birds, and insects, for example, are much more common on islands than other taxa with lower dispersal capacity. Of the newly arrived species, only a few will be able to survive and establish new populations. As a result, islands have fewer species than mainland habitats. Island populations are small, exhibit low genetic variability and are isolated from the predators and competitors with which they initially evolved [6]. These small islands are also known to present high levels of endemism, mainly due to disjunct geographical distribution and limited dispersal of seeds. These favour genetic differentiation, which, in turn fosters endemism [7, 8, 9]. These endemisms have small population distribution, and present low competitive ability [6].
The isolation and small size of the oceanic islands makes them very vulnerable, highly susceptible to threats such as climate change, natural catastrophes, coastal erosion, seawater intrusion, and overexploitation of natural resources [10]. They are also very vulnerable to invasive alien species, that compete with the native taxa, causing severe ecological and economic problems. Besides, deforestation is frequently a major problem, both for agriculture and for timber, and tourism is causing additional infrastructural and pollution pressure [6]. Biodiversity conservation and sustainability are accordingly major concerns in relation to the oceanic island, to preclude the degradation and destruction of the natural heritage.
The effort of creating protected areas is the first key step to the conservation of threatened natural and cultural heritages. This step should be followed by a successful management of the protected area, which considers both the conservation of ecosystems and the socio-economic development of island inhabitants and considers the specificities of island territories.
This chapter discusses the importance of the oceanic islands, of its endemic plants, the threats they are currently facing, and the conservation measures being implemented to protect these important ecosystems.
There are around 374,000 plants species on earth [11], but their distribution is uneven, with the tropical environments presenting larger numbers than other environments. This is a result of ecoevolutionary drivers which include the climatic stability over the past million years associated with time, energy availability, and biotic interactions [12]. Consequently, some areas of the globe have been recognised as global biodiversity hotspots as they exhibit exceptionally high species richness and high endemism levels [13]. Mittermeier et al. [14] have defined 35 biodiversity hotspots, many of which are oceanic and continental island archipelagos.
The colonisation of the small oceanic islands depends on geographical and environmental drivers, being inversely related to the distance to other lands [15]. Another important factor is the dispersal ability of the organisms. The geographical range of a
When a plant species is able to reach a new territory, it depends on its ability to adapt to the physical and chemical characteristics of the island, and to other biotic factors such as competition, herbivory, parasitism, and symbiosis [3]. The few taxa that survived and adapted to the new environment may therefore evolve into new species. Due to the time these adaptive processes take, island age is an important factor for the biodiversity of oceanic islands, as older islands have a higher probability of successful colonisation. They also had more time for selection processes to act on the first colonisers, so that natural selection takes place, thus constituting a favourable factor for speciation. Because of their evolutionary processes, oceanic islands are poor in the number of species for their size, but present a remarkable high ratio of endemism, and the ecosystems exhibit much higher biodiversity than terrestrial ecosystems for the same area [1, 6]. E.g., the East Melanesian Islands, comprising the Solomon islands, Vanuatu and Papua New Guinea, include around 8,000 plant species of which about 3,000 are endemic, the Atlantic islands of Macaronesia are the third richest hotspot in the world in terms of its plant biodiversity (25,000 species); 5,330 species of native vascular plants are native to Polynesia-Micronesia, of which more than 3,070 are endemic, Japan has more than 5,600 plant species of which roughly a third are endemic [17]. Hawaii archipelago also has about 1180 native vascular plants, of which 1000 are angiosperms. Of these, about 900 are endemic (Figure 2) [18].
Endemic plant species from oceanic islands. Top left:
These endemic species, however, present restricted geographical range, specialised environmental niche, limited dispersal ability and reduced size population and distribution [19]. The islands with high large proportion of endemic plants are mainly the high volcanic islands, while most the low islands are species poor. The smaller the island is, the more isolated, and the less the topographic relief, the poorer the island. This is due to the reduced variety of habitats and the broad mix of the typically sea-dispersed strand species that dominate their floras [1].
All habitats are exposed to an ecological succession and to natural disturbances, namely volcanic eruptions, or tropical cyclones, that significantly alter the animal and plant populations. As defined by Pickett, disturbance is “a change in the minimal structure of an object caused by a factor external to the level of interest” [20].
Oceanic islands are also subject to numerous disruptive events such as hurricanes, high winds, heavy rains, high pressure systems, earthquakes, volcanic eruptions, tsunamis, extreme tides, the introduction of exotic species and human activities. These have mechanical, physiological, or biotic impacts that can last for years. In fact, because most oceanic islands are small and located in harsh environments, these disturbance events tend to have more severe consequences on oceanic islands than on continental land masses [1].
In addition to these natural disturbances, humans have had a profound impact on biodiversity, altering the composition and functioning of ecosystems. These events are of the utmost importance for the survival of wild habitats and the viability of populations.
After a disturbance event, when the number of individuals falls below a specific threshold, the species loses genetic diversity, which reduces its ability to adapt to change and therefore increases the risk of extinction. Island endemic species are usually very localised and have small numbers of individuals, which makes them highly vulnerable to disturbance and therefore to extinction [21].
With human settlement on oceanic islands new species were introduced as farm stock, crops, for fibres or furs, domestic animals, pets, sports, or solely as ornamentals [22, 23]. Other species, however, were introduced due to military operations, international trade, and globalisation, either ship cargoes, ballast water, shipwrecks, which unintentionally transported these exotic species to the island, whether plants or animals (Figure 3) [24]. More recent invasions drivers are climate change, land-use change providing new habits, pollution, and the positive interaction among non-native species, a process known as invasion meltdown [25, 26].
Invasive alien mammals: top right: mouse (
An introduced species is a species that (1) owing to human activity colonises a new area where it was not previously present, (2) is remotely dispersed with a wide geographic discontinuity, and (3) becomes naturalised by perpetuation of new generations without human intervention [27]. Luckily, most introduced species do not become established, due to mortality during translocation, unsuitable environmental conditions and biotic resistance exerted by the host community [28].
Nevertheless, once established, it can become a new invasive alien species (IAS) when it has an undesirable effect on the native ecosystems. The ecological and economic impact of IAS may be after the invader is well established and have wide range, and then the damage may be extremely severe. IAS are responsible for altering the ecosystem functioning, modifying native species richness and abundance, and increasing the risk of extinction, breaking down biogeographic realms, affecting the genetic biological diversity, changing the phylogenetic diversity across communities, and modifying the trophic networks, as well as disturbing human health and/or socioeconomic values at the individual, population, or community level [25, 29, 30, 31]. “Habitat transformers” species, which cause changes in ecosystem nutrient cycling at microbial or higher plant levels [32] and “ecosystem engineer” species, which are landscape modifier species [33], are particularly dangerous for they are strongly competitive IAS with the ability to alter environmental conditions, being a major contributor to species diversity loss. As such, IAS alter the composition of plant and animal communities, and also interfere with other ecosystem processes such as nutrient cycling, hydrological cycles, and primary productivity [34].
Accordingly, IAS may have severe negative impacts on oceanic islands because these ecosystems are species-poor and have few highly competitive species [30]. IAS impacts on islands are intensified through the interaction with other global change threats, including over-exploitation of natural resources, agricultural intensification, urban development, and climate change, exacerbating some invasions, and facilitating others, escalating the impact and the extent of IAS [35]. Currently, IAS may be the main cause for ecological disintegration globally, and thus the early detection, rapid action in eradication and good planning is of utmost importance, mainly on islands or other limited habitats [23].
Climate change poses serious risks for human and natural systems. Species are shifting their geographic ranges and altering the numbers of individuals in their populations, variations in seasonal activities, migration patterns and interactions between different species are also occurring in response to ongoing climate change. The impact from recent climate-related extremes, such as heat waves, floods, droughts, cyclones, and fires, reveal significant vulnerability and risk of many ecosystems, some irreversible. To make matters worse, carbon stored in the terrestrial biosphere in peatlands, permafrost, and forests, among others, may be lost to the atmosphere, exacerbating ecosystem degradation. Furthermore, the sea level rise projected for the 21st century and beyond will have an enormous impact on coastal systems, islands, and low-lying areas, which will suffer adverse impacts such as submergence, flooding and coastal erosion. These impacts will be extremely severe on low-lying developing countries and small island states [36].
Due to climate change, the intensity and frequency of wildfires is also increasing [37]. Besides the noticeable economic impact, heat dramatically disturbs soil surface, often causes a decrease in diversity and abundance of soil biota, and strongly increases the risk of erosion by wind and water [38]. These effects depend upon fire severity, and some fire regimes are beneficial to ecosystems. These are controlled by environmental factors such as amount, nature, and moisture of live and dead fuel, air temperature and humidity, wind speed, and topography of the site [39, 40]. Due to climate change, induced wildfires are becoming more frequent and are more aggressive and, thus, have frequently severe negative impact on the vegetation and on sensitive species.
Islands are particularly vulnerable to climate change disturbance, owing to the vulnerability of island endemic plants, due to habitat loss and interactions with introduced species [41]. The IAS may benefit from climatic change, as they are opportunistic, very competitive species, thus less vulnerable due to their adaptability to new environments [42]. Manes et al. [41] study stated a 100% risk of extinction for island ecosystem due to climate change and a risk of extinction 3 and 10 times higher for endemic than native and introduced species, respectively.
As such it is expected a decline of endemic plants in oceanic islands, a degradation of mangroves, wetlands, and seagrass around small islands, a degradation of groundwater and freshwater ecosystems due to saline intrusion, a spread of warm water species into the Mediterranean, namely IAS, among many other negative impacts attributed to climatic change [36].
Steffen et al. [43] postulate that the Anthropocene’ era is rapidly approaching levels of human-induced greenhouse gases that are approaching critical levels. When reaching an irreversible threshold, the devastating consequences will be irreparable for the distributions of species and in the composition of biological communities. Many of these impacts may already be permanent.
Disregarding the impact of the pandemic Tourism and Leisure are among the fastest growing economic activities of recent decades [44]. Yet, touristic activities are well known by their negative consequences, being responsible, for instance, for greenhouse gas emissions [45], high patterns of visitor consumption and waste generation [46], for plant damage, including vegetation removal and changes in land cover and land use [47], tourists trampling and spreading weeds and pathogens, and altering fire regimes [17, 48]. Tourists also often pick flowers, threatening the more charismatic species [49]. Tourism, thus, have negative impact in the wildlife, health, physiology, reproduction rate, and behaviour of the wild species [45, 50, 51, 52, 53], prompting the decline of sensitive plants, while favouring the growth of resistant species, frequently opportunistic and exotic ones [49].
Thus, tourism is frequently an unsustainable activity not complying with the UNWTO definition of sustainable tourism as “tourism that takes full account of its current and future economic, social and environmental impacts, addressing the needs of visitors, the industry, the environment and host communities” [54].
The presence of tourists in Protected Areas is especially sensitive, for the number of visitors in a protected area increase the number of exotic species on site, since visitors increase propagule pressure and disturbance [28]. More disturbed habitats create open space that may allow IAS to establish and, thus, offer invaders an edge against native species [24].
Yet, due to the dependence on a healthy and safe environment, a social change seems to be arising within tourists and policymakers, increasingly seeking more environmentally friendly practices and tourism activities, through the development of nature-based tourism and ecotourism [55, 56]. In fact, more sustainable tourism activities are increasingly supporting wildlife conservation and local populations welfare are becoming a reality in many countries with pristine ecosystems and charismatic species [57, 58, 59].
Agriculture is intensifying at global level, and this trend will continue in the next years, to meet the growing human population needs. This agriculture expansion will bring ecosystem simplification, loss of ecosystem services, and species extinctions [60]. The agricultural spreading could have major impacts on biodiversity hotspots, as these are areas where there is significant population growth, often poor and with a low development index, where there is an increasing pressure to produce food and promote economic growth through the commercial use of natural resources [61]. In fact, many tropical protected areas, are suffering forest loss through agricultural intrusion, often to grow palm trees for biofuels, being a cheap source of oil [62].
Forest loss has also been occurring through legal or illegal logging, conversion to small-scale agriculture, and larger-scale commercial plantations, namely in the Amazon, Africa, and Asia, but also in small tropical islands, such as New Britain [63]. At the community level, large trees contribute extensively to ecosystem functioning and provide key habitats for biodiversity [64]. Logging is known to degrade forest structure, creating gaps, removing soil, and fostering the proliferation of IAS [65].
Human population has more than doubled since 1950 and for the next half century there should be a continued rapid growth in the least developed regions [66]. This massive growth in human population has serious consequences for natural habitats, with increasing pollution, the spread of IAS, carbon emissions and the consumption and destruction of natural resources, resulting in the change of many of the last remaining wild spaces on the planet [67]. Therefore, fewer world ecosystems are away from human pressure, and many are experiencing biodiversity loss and ecosystem degradation due to the construction of infrastructures, for vehicles, for the industry, for hydraulic and harbour set-ups, hydroelectric infrastructures, among others, with severe impacts on many ecosystems and species. Roads, for example, open new opportunities for habitat fragmentation, fires, logging, and land speculation [68, 69]. The rapid proliferation of roads will also strongly influence the footprint of agriculture. Thus, wild regions, parks and protected areas, relics of intact habitat within biodiversity hotspots, such as islands, are among the environments where roads and other infrastructure should be limited, allowing the conservation of such habitats and species [68, 70].
Besides the roads, the building of infrastructures for urban expansion, tourism, or for other economic activities, has, evidently, direct impact in the vegetation clearance, to open the area. However, beyond the immediate impact on the vegetation, such infrastructures have a long-term impact, due to habitat fragmentation, the changes caused on the soil hydrology, pollution runoff, and as already mentioned, as a corridor for the introduction of pathogens and IAS [71, 72].
Protected areas (PAs) are the main pillar of conservation activities and are therefore the first integrated approach for the conservation of biodiversity and ecosystem services worldwide [73]. Acknowledging the worldwide recognition of the importance of the PAs as a tool for the economic, social, and scientific importance, and for their role in environmental well-being, the total PA has increased tenfold from 1959 until 2016, from roughly 2 Mkm2 to almost 20 Mkm2, corresponding to 202,467 total PAs. In 2014 around 17% of the world island biomes were protected, mainly temperate (23%) and polar ecosystems (17.5%), while less than 13% of tropical islands were protected, where endemism is higher [74]. Also, the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services report [36] and the recent Global Biodiversity Outlook [75] noted some interesting progress in the conservation and sustainable use of biodiversity in PAs.
Although more recent reports do not include data on islands, between 2014 and 2020 the protected land and inland water ecosystems increased from 15.4% to 16.64% (with a total of 22.5 million km2 and 248,113 protected areas), and the protected coastal waters and the ocean increased from about 4.5% to 7.74% (28.1 million km2 and 17,828 protected areas) [76, 77]. This growth falls within the conservation efforts tackled by the Aichi Biodiversity Targets under the Convention on Biological Diversity (CBD). Still, despite the progress in conservation and sustainable use of biodiversity, the Strategic Goal 11 has been tightly missed: “by 2020, at least 17% of terrestrial and inland water areas and 10% of coastal and marine areas, especially areas of particular importance for biodiversity and ecosystem services” [78].
While many of the endemic species’ populations are within protected areas, often these are not enough to fully protect them, because, among other problems, management quality is not satisfactory, and thus biodiversity loss has persistently continued [79]. Therefore, it seems that the extensive conservation efforts are not being successful and new approaches are needed.
Current conservation strategies are still largely based on the assumption that we live in a dynamic but slowly changing world. Such an assumption needs to be revised considering the rapid rate of climate change already experienced in recent years, which is expected to continue at this pace if not increasing, over the coming decades, forcing researchers and managers to rethink and recalibrate the conservation responses [80]. On the other hand, conservationist classical approaches are based mainly on
Due to lack of knowledge and interest, plants are often under protected by policy, their conservation efforts are underfunded, and their importance is under cherished. To overcome such lack of information, an Important Plant Areas (IPAs) criteria system was defined, offering a pragmatic and scientifically rigorous mean of delivering these datasets, assisting the informed decision making and conservation prioritisation [83]. This database generates essential data for other databases such as the IUCN Key Biodiversity Areas (KBAs) programme [77] producing a worldwide network of relevant information. The database, however, is still rather limited, for many countries have not yet made available the data on the distribution, rarity and threat status of plant species and their habitats, mainly in the tropical areas.
The IPA criteria, for the first time, recognises the socio-economically valuable plant species providing essential goods, such as the importance of plants as a food source, medicines, timber, fuel, materials for clothing, ornamental, social and cultural traditions, besides the vital ecosystem services [83].
The identification of the biodiversity hotspots and endemism centres, along with the assessments summarised by the IUCN red list categorisation [84] and creating global, national, and regional lists of threatened species, are, likewise, valuable tools in conservation prioritisation and planning [85]. Most countries have national agencies responsible for gathering information on native ecosystems, habitats, endemic species, PAs, in regional or national databases, fundamental information for the implementation of conservation actions.
The improvement of biological and ecological knowledge will allow to better target conservation measures.
Besides the legal protection at regional and national levels, there are several international cooperation treaties to tackle the threats on wildlife and nature protection. The following are some of the most important, within the plant conservation:
Ramsar Convention on Wetlands (1971) which promotes de wise use of wetlands, encouraging the research, training, and management of these ecosystems [86].
The Convention for the Protection of the World Cultural and Natural Heritage (1972), aiming to ensure the identification, protection, conservation, presentation, and transmission to future generations of the cultural, and natural heritage [87].
Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) (1973), seeking to regulate the international trade in endangered animals and plants, and in products derived from them [88].
Convention on Biological Diversity (1992), which aims at the conservation of biological diversity, the sustainable use of its components, and the fair and equitable sharing of the benefits of utilising the genetic resource. It also set ambitious goals to restore and safeguard ecosystems, promote sustainability, halt biodiversity loss, combat desertification, among others [74].
International Plant Protection Convention (1951) aims to protecting the world’s plant resources from the spread and introduction of pests and promoting safe trade [89].
Although each of these international treaties stand on its own, regarding their objectives and commitments, they are inter-linked between their goals and complement each other. Each convention governing body set out specific mandates for cooperation between the biodiversity-related conventions, providing a framework for joint action of biodiversity and a foundation for sustainable development [74].
The PA creation, as stated, is probably the number one national and international conservation policy. They are regarded as the primary defence against biodiversity loss, as long as they are well maintained and managed [6, 67, 81]. The Aichi Biodiversity Targets are a strong showcase of the political priority given to the creation of protected areas at the international level. The following are key messages to achieve the Aichi Targets for APs [77]:
Ensuring a more sustainable future […] will require greater recognition of the important role that PAs play in underpinning sustainable development.
Making PAs a key part of national and local responses to address harmful incentives to biodiversity (Target 3), biological invasions (Target 9), anthropogenic impacts and climate change challenges (Targets 10, 15) will help to halt biodiversity loss (Targets 5 and 12), […].
Complying with these guidelines, IUCN developed a set of educational tools for teaching about PAs and governance aiming to produce a “well-implemented legal frameworks [to create and maintain] effective and sustainable PAs, which provide fundamental infrastructure for conservation of biological diversity and ecosystem services” [90]. These guidelines are helping to create and implement efficient management plans, making them an effective tool to guide managers and other stakeholders in the decision-making process towards achieving the conservation goals.
However, PAs coverage and management plans are not enough to ensure the PA conservation success. Presently, not all the important biodiversity hotspots occur inside the PAs [91, 92, 93, 94], because the PA area is at times inadequately defined in terms of extent, ecological representation, and key biodiversity areas [95]. Another major bottleneck is that many PA are inadequately managed and, therefore, do not fulfil their goal of providing a safe and secure site for the species, populations, and ecosystems to thrive.
While biodiversity conservation is the primary objective of a PA, successful management must also address the funding and training requirements of conservation actions, as well as ensuring the sustainability and socio-economic development of local communities [6]. Balancing conservation interests and human well-being is often the most difficult challenge to successfully manage a PA. Therefore, local populations ought to be involved at all stages of the PA management planning, notably in defining the mission, vision, and goals of the PA [6].
Besides all these challenges, in the present days, the greatest threat to PAs is, probably, climate change. How far protected areas will continue to be effective in protecting biodiversity under projected climate change scenarios is still uncertain, but it is expected that some PAs will virtually cease to function, with massive species loss and shift, others may survive relatively undisturbed, while others may even experience an increase in species, leading to changes in the species assemblages [81].
When it comes to island PAs, the intrinsic characteristics of island species and ecosystems cause a particular vulnerability due to the small population sizes, low habitat availability, and isolated evolution [96, 97]. Strong local anthropogenic pressure added to the impacts of climate change increase the threats to island ecosystems and plants. Due to the high degree of endemism in island floras, there is a particularly high potential for biodiversity loss in these ecosystems. Climate change impacts on oceanic island, though, are not evenly distributed, with the greatest vulnerabilities to be expected on smaller islands with low elevation and uniform topography, which will experience higher disruptions rates associated with ecosystems co-modification and co-extinction [98]. Thus, islands PAs are much more vulnerable than other land ecosystems, and management plans must take this into account.
In oceanic islands, as stated, biological invasions can lead to severe large-scale ecosystem alterations. Thus, the eradication of IAS has been a common management practice in island PAs, being widely recommended [23, 96, 99, 100, 101, 102, 103, 104].
Eradication of IAS in general is a complex and controversial management action. On islands it is attainable in the early stages of invasion [35], but later it is largely restricted to a few invasive mammals such as rabbits and rats [105] and then, for most species, permanent pest control is the only option.
Most of the already mentioned measures must be applied to the control of IAS. First, the knowledge of the IAS present is fundamental. There are many IAS listed around the world, a study that has been undertaken during the past 50 years or so. The Invasive Species Specialist Group developed a global invasive species database [106], and many countries have regional and national databases, although there is still work to do on this subject.
Coordination between countries and trans-national management plans are required to allow the development of joint actions across geographical areas that go beyond each country’s frontiers. To this purpose the Aichi Target 9 established “By 2020, invasive alien species and pathways are identified and prioritized, priority species are controlled or eradicated, and measures are in place to manage pathways to prevent their introduction and establishment” [78].
This target addressed the following implementation measures:
Improved border controls and quarantine […].
Development of early warning mechanisms, rapid response measures and management plans.
Prioritise control and eradication efforts to those species and pathways which will have the greatest impact on biodiversity and/or which are the most resource effective to address.
A special reference is made for the island’s ecosystems, due to the acute impact of invasive alien species on island ecosystems.
The Invasive Species Specialist Group also developed a Toolkit for the economic analysis of Invasive species [107] which addresses the causes and the impacts of IAS, the related costs and benefits, the valuation of ecosystem impacts and the actions to address IAS.
Besides the information, the international and national legislations, the definition of biosecurity programs is also important, identifying IAS that pose a high risk of causing damage, and establishing measures to protect natural resources and citizens. Currently, biosafety on plant IAS is governed internationally by the International Plant Protection Convention, which establishes harmonised guidelines and standards between countries to limit the spread of IAS while promoting free trade [25].
Addressing IAS control in islands is less difficult than in continental land masses since it may be possible to prevent the entry of these IAS at the border in the management plan. Yet, it is a complex operation. The engagement of the community (citizen science) is of utmost importance, to allow early identification of new invasions. Engaging volunteers in surveillance and monitoring is also a low-cost, large-scale, and a long-term option, for those countries that are not able to implement integrated IAS surveillance programs [25].
Established populations of IAS have traditionally been managed by mechanical or physical control, chemical control, and biological control, all with successes and failures, but with increasing efficiency [108]. New management and innovative eradication technologies have been implemented in recent years, based on molecular genetics, notably the use of gene-silencing for the control of invasive populations that affect plants [109], or gene-editing technology, together with transgenes, which is a whole new technological approach that can help in the control and management of IAS [110].
As defined by article 8 of the CBD,
The
The use of
Ecosystem restoration approaches, including ecological restauration.
Issue-specific ecosystem-related approaches, including ecosystem-based adaptation, and ecosystem-based disaster risk reduction.
Ecosystem-based management approaches, such as integrated coastal zone management.
Ecosystem protection approaches, including protected area management.
Natural and green infrastructure-related approaches.
Accordingly, many NbS being implemented in PAs fall within the species and ecosystems conservation measures, as well as within the management tools that must be adopted when PAs are involved. In small oceanic islands, NbS can provide significant human wellbeing and biodiversity benefits, linking ecological, climate, and human wellbeing issues in an integrated, ocean-focused, and climate-responsive manner [122, 123].
The conservation of endemic plants in protected areas of oceanic islands is a vast, complex, and challenging topic, which has received the attention of many researchers in the past. These plants grow in small population due to low habitat availability, and isolated evolution. Therefore, the islands’ ecosystems and their endemic plants are very vulnerable to current threats, such as climate change and the introduction of invasive alien species, but also to pollution, habitat fragmentation, fire, and other anthropogenic threats.
The conservation measures implemented so far are not consensual and many have not been successful, although important steps have been taken. The study and definition of major biodiversity hotspots, the establishment of thousands of protected areas, the creation of databases with information on relevant habitats and species, and the implementation of many
New scientific approaches are appearing in conservation, namely the Nature Based Solutions, the conservation-oriented restoration, the gene-editing technology together with transgenes, which are already showing promising results in plant conservation.
Despite the scientific efforts, the importance of efficient management of protected areas and of the political priority given to conservation should be stressed. Without them, all scientific achievements are irrelevant.
This study had the support of Fundação para a Ciência e Tecnologia (FCT), through the strategic project UIDB/04292/2020 granted to MARE. I acknowledge the Saxifraga foundation (http://www.freenatureimages.eu/) for providing the free photo of
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. from Integral University, Lucknow, India, with his work titled ‘Development and evaluation of silymarin nanoformulation for hepatic carcinoma’. Currently, he is an Assistant Professor of Pharmaceutics, at the Faculty of Pharmacy, Integral University. He has been teaching PharmD, BPharm, and MPharm students and conducting research in the novel drug delivery domain. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than twenty-four original journal articles, two edited books, four book chapters, and several scientific articles to his credit. He is a member of the American Association for Cancer Research, the International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}}]}},subseries:{item:{id:"4",type:"subseries",title:"Fungal Infectious Diseases",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. 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Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,series:{id:"11",title:"Biochemistry"}}},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. 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