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1. Introduction
Story of N-heterocyclic carbene builds up from an unstable non-isolable reactive species to a stable and highly flourished ligand for the synthesis of a variety of organometallic compounds and many important catalytic reactions. Based on the orbital occupancy of the electrons, carbenes can be classified as singlet and triplet carbenes. In singlet carbene, a lone pair of electron occupies sp2-hybrid orbital (Figure 1A) whereas, in triplet carbene, two single electrons occupy two different p-orbitals (Figure 1B). Carbenes are inherently unstable, hence highly reactive species due to incomplete electron octet. Initial reports of isolable carbene came in the late 1980s, where the carbene is stabilized by adjacent silicon and phosphorus substituents.
Figure 1.
(A) Singlet carbenes; (B) triplet carbenes.
Credit for the discovery of stable and isolable carbene goes to Arduengo, where carbene carbon is a part of a nitrogen heterocycle and gave the first N-heterocyclic carbene (NHC) compound called 1,3-di(adamantyl)imidazol-2-ylidene briefly called IAd (Figure 2A) [1]. Since then NHC compounds are enjoying their success to several dimensions of synthesis and organic transformations.
Figure 2.
(A) Structure of IAd; (B) percent buried volume (% Vbur).
1.1 Structure and general properties of NHCs
Thus, a heterocyclic compound with a carbene carbon and at least a nitrogen atom adjacent to it within the ring can be termed as NHC [2]. NHCs are singlet carbenes and their remarkable stability is contributed by both steric and electronic effects. Dimerization of carbene carbon is kinetically frustrated by keeping bulky groups on the two sides of the carbene carbon, as is the case with IAd (Figure 2A) where two adamantyl groups are attached to the nitrogen atoms (adjacent to the carbene center). Nolan and his co-workers have quantified the steric properties in terms of the ‘buried volume’ parameter (% Vbur) (Figure 2B) [3]. Metal ion of the NHC-metal complex is assumed to be at the center of a sphere and then % Vbur is calculated as the portion of the sphere occupied by the NHC ligand (Figure 2B). Larger the value of % Vbur, greater is the steric repulsion at the metal center. The buried volume is usually determined from crystallographic data of the NHC-metal complex [4] or directly from theoretical calculations with the free NHC.
The value of % Vbur is affected by both the nature of the NHC ligand as well as the geometry of the NHC-metal complex; therefore, data is useful only for the comparison within the same family of complexes. A small change in the structure of ligands may bring more than 10% increase or decrease in percent buried volume [5]. Caution should also be paid as the calculation of % Vbur is carried out in solid-phase through crystallographic data analysis or in gas phase by DFT calculation. In both the methods the behavior of the complexes in solution and solvation is not considered where ligand may adopt several conformations. The stability of an NHC is far more affected by the electronic factor. Carbene carbon of NHC has three sp2-orbitals orientated in triangular planar fashion and one p-orbital (pz) perpendicular to the plane of the NHC ring. Two sp2-orbitals are bonded with two nitrogen atoms in the ring and one sp2-orbital houses the lone pair of electrons. The two nitrogen atoms stabilize the carbene carbon in two ways: (i) by withdrawing the sigma-electrons through inductive effect and (ii) through a π-electron donation to the empty pz-orbital of the carbene carbon (mesomeric effect). This π-electron donation is so strong that NHCs are also described by its zwitterionic resonance structure and is evident by the intermediate bond length of carbene C-N bond (1.37 Å) in IAd, which falls in between C-N single bond length (1.49 Å) and C-N double bond length (1.33 Å) of the corresponding analog compounds (IAdH2 and IAdH+ respectively). In the molecular orbital model, sp2 and pz-orbital can be described as HOMO (A1 non-bonding molecular orbital) and LUMO (B2* bonding molecular orbital), respectively (Figure 3) [6, 7]. The cyclic nature of NHCs is also an important structural aspect as it creates a preferable situation for the singlet state by forcing the carbene carbon to adopt a more sp2-like arrangement.
Figure 3.
Molecular orbital diagram of an NHC.
Like the phosphines, the electron-donating capability of NHCs is evaluated using Tolman electronic parameter (TEP) [8]. Any build-up of electron density on the metal center of the complex [Ni(CO)3(NHC)] due to electron donation by the NHC is reflected by the decrease in the infrared-stretching frequency of CO bonded with the metal ion. Now-a-days, instead of [Ni(CO)3(NHC)], less toxic [(NHC)IrCl(CO)2] and [(NHC)RhCl(CO)2] are used and a correlation formula is used [Eqs. (1) and (2)], respectively [9, 10].
TEP=0.847.νCOIr+336cm−1E1
where, νCO(Ir) = average IR-stretching frequency of CO in [(NHC)IrCl(CO)2] complex.
νCOIr=0.8695.νCORh+250.7cm−1E2
where, νCO(Ir) = average IR-stretching frequency of CO in [(NHC)IrCl(CO)2] complex, and νCO(Rh) = average IR-stretching frequency of CO in [(NHC)RhCl(CO)2] complex.
1.2 Synthesis of NHCs precursor and generation of carbene
Azolium or dihydroimidazolium salts are sufficiently stable solids and the generation of NHCs can be carried out in situ by their deprotonation using non-nucleophilic bases such as sodium hydride, butyllithium or t-butoxide. Alkoxides form an adduct with azolium salt, however, in presence of transition metal precursor, NHC is transferred to the metal and usually moves toward complex formation rather than the disruption of the azolium ring. Generation of NHCs is also carried out using mild metal oxides like silver (I) or copper (I) oxides where after generation, NHC forms NHC-silver(I) or copper(I) complexes and in situ transfer of NHC occurs to the desired metal center. A general protocol for the synthesis of NHCs and NHC precursor 11 is outlined below in Figures 4 and 5, respectively [11, 12].
Figure 4.
General protocol for the synthesis of unsymmetrical substituted NHCs.
Figure 5.
Synthesis of NHC precursor 11.
1.3 Generation of NHCs
Formation of saturated and unsaturated NHCs upon treatment with an alkoxide base is shown in Figure 6A and B, respectively [13].
1.4 Coordination of NHCs to transition metals
Thus, the coordination of NHC ligand to the transition metal ion occurs largely through the strong σ-donation of the formal sp2-hybridized lone pair to a σ-accepting orbital of the transition metal and a weak but not inconsiderable π-donation [14] either in the form of π-back donation from metal to the pz orbital of the ligand or vice versa [15, 16]. However, in practice a single bond is drawn since the free rotation energy across the M-C bond is very low (Figures 2B and 6).
Figure 6.
Treatment with an alkoxide base leads to formation of (A) saturated NHCs; and (B) unsaturated NHCs.
1.5 Phosphine versus NHCs
NHCs are being compared with strong sigma donating ligands like phosphines and cyclopentadienes. As a ligand, NHCs edge ahead of phosphines on several points:
Electron donor: NHCs are relatively stronger electron-donor than phosphines and produce thermodynamically stronger metal-ligand bonds, except when there are steric constraints interfere with metal-ligand binding [17].
Steric properties: Whereas the spatial arrangement of steric bulk takes up a cone-shape due to sp3-hybridization of phosphines; most of the NHCs results in umbrella-shaped steric bulk and the orientation of the substituent on the two nitrogen atoms are more toward the metal center. Thus, the steric crowd around the metal center can be tuned by changing the substituent on the two nitrogen atoms and the heterocyclic ring, if required.
Ease of varying their steric and electronic properties: There are several well-established synthetic routes to tune the steric and electronic properties of NHCs, whereas it is usually difficult to tune the properties to the desired level for the phosphines.
In the case of phosphines, changing the substituent on the phosphorus inevitably changes both steric and the electronic properties whereas each parameter can be modified independently through modifying the substituents on nitrogen, functionalities on the heterocycle and the type of heterocycle itself.
2. Various motifs of Fe-NHC complexes
The structural diversity in various motifs of Fe-NHC complexes is shown in Figure 7 and each of them is explained below along with their known applications in different areas.
Figure 7.
Different motifs of Fe-NHC complexes.
2.1 Mono- and bis-(mono- or chelating) carbene ligands
2.1.1 CO complexes
The chemistry of Fe-NHC complexes began with the synthesis of their unsaturated and saturated ligand precursors with carbonyl as their motifs, and extensive studies on molecular structure determination and reactivity (Figure 8A–D). These CO complexes were further subjected to substitution reaction, e.g. ligand exchange with monophosphines and oxidation, to develop newer Fe-NHC complexes (on oxidation their geometry tends to change from trigonal bipyramidal to distorted square pyramidal). These transformations, in progression, led to the formation of new classes of complexes with novel attributes viz. monocarbene, bis-monocarbene, and chelating biscarbene ligands having variable oxidation states of iron from Fe(0) to Fe(II), which contributed to new horizons in bioinorganic chemistry and biomimetic systems e.g. Novel Fe(II) monocarbene complexes (Figure 8C) as models for basic structure of the monoiron hydrogenase [18].
Figure 8.
(A–D) CO complexes; (E–G) NO complexes.
2.1.2 NO complexes
Synthesis of novel and intriguing Fe-NHC complexes in the field of biomimetic chemistry e.g. dinitrosyliron complexes (DNICs) (Figure 8G) displaying a variety of vital biological functions [18], forced the scientific community to shift their attention toward novel monocarbenes and bis-monocarbene ligands having nitrosyl as their structural attributes (Figure 8E–G). Not only as biomimetic structural models, these nitrosyl complexes can act as catalyst in chemical transformations e.g. allylic alkylation [18, 19].
2.1.3 Halide complexes
Just like carbonyl and nitrosyl motifs in Fe-NHCs chemistry, halides do play a major role in influencing the role of Fe-NHC complexes in both catalysis as well as biomimetics. Halide complexes catalytic role varies from polymerization catalysis by bis-monocarbene dihalide Fe-NHC complexes [18, 20] C-C cross-coupling reactions catalyzed by dinuclear Fe-NHC imido complexes [18, 21] to catalytic hydrosilylation by ethylenediamine-derived Fe-NHC complex [18]. Depending upon the structural versatility in halide complexes, many subclasses have been synthesized and studied, namely monocarbene ligands, bis-monocarbene ligands, chelating biscarbene ligands, dinuclear Fe-NHC imido complexes, halide-bridged Fe-NHC complexes, immobilized Fe-NHC complexes, three-coordinate Fe-NHC complexes (Figure 9A–G).
Figure 9.
(A–G) Halide complexes.
2.2 Donor-substituted NHCs
Effects on the reactivity of organometallic iron complexes could be observed when the ligand environment changes from CO, NO, halides to donor-substituted NHC ligands (Figure 10A). These donor-substituted NHC ligands possess nitrogen or oxygen as heteroatoms, thus present themselves as potential coordinating “arms” attached to the NHCs and exhibit coordination from bi- to pentadentate as ligand systems. These complexes have shown their catalytic role in ring-opening polymerization of ε-caprolactone [18, 22].
Chelating biscarbene pincer ligands (Figure 10B) are an extension of donor-substituted NHCs in Fe-NHC chemistry, where instead of the presence of heteroatoms as “arms”, two NHC units are linked by a pyridyl moiety and hence “chelation”. Structurally, pincer motifs exhibit two coordination geometries predominantly, octahedral and square pyramidal, due to their strict binding mode to three adjacent coplanar centers. Catalysis by Fe-NHC complexes bearing pincer motifs has been demonstrated by their catalytic role in concerted C-H oxidation addition reaction [18], hydroboration reaction [18, 23], and hydrogenation reaction [18].
2.4 Scorpionato motifs
Scorpionato-type motifs (Figure 10C) means boron linked anionic chelating triscarbene ligands and on complexation with iron results in a new class of Fe-NHC complexes. Therefore, if any iron complex/compound is bearing two scorpionato-type ligands, it will be, (a) coordinated by six carbenes, (b) highly stable, and (c) showing S6 symmetry along Fe-B-H axis [18]. Different types of scorpionato-type motifs have also been synthesized e.g. tripodal borane NHC iron complexes [18], amine-bridged scorpionato Fe-NHC motifs [18].
2.5 Macrocyclic ligands
Macrocyclic ligands, despite well-investigated other cyclic ligands such as cyclam, porphyrin, on complexation with iron developed a new class of complexes in Fe-NHC coordination chemistry (Figure 10D). Their catalytic aspect has been successfully employed in aziridination of alkenes with aryl azides [18, 24].
2.6 Piano stool motifs
The term “piano stool Fe-NHC complexes” states that all such complexes bear both, (a) N-heterocyclic carbene motif and (b) cyclopentadienyl (Cp) ligand. The structural variations in these complexes are well explained by (a) mono- and dimeric piano stool Fe-NHC complexes [18], (b) donor-substituted piano stool Fe-NHC complexes [18], (c) biscarbene-chelated piano stool complexes [18], (d) alkyl piano stool Fe-NHC complexes [18], (e) three coordinate piano stool Fe-NHC complexes [18], and many more [18] (Figure 10E–G). These have shown their catalytic activities in C-H bond activation [18], borylation reactions [18, 23], hydrosilylation [18, 25, 26, 27], transfer hydrogenation [18], C-N bond formation [18, 24].
2.7 Iron-sulfur clusters
Diiron dithiolate complexes (Figure 10H) have been reported to mimic the active site of [FeFe] hydrogenase [18]. Also, the substitution of carbonyl motifs (one or more) in the diiron dithiolate complexes by σ-donor ligands (in this case NHCs) is shown to influence the redox potential of the iron center [18]. Further, donor-substituted NHCs motifs were included in the molecular framework of [FeFe] hydrogenase model compounds to extend its molecular assembly [18]. Another notable characteristic presence of Fe-NHC complexes bearing iron-sulfur clusters was demonstrated in synthesis of nitrogenase model compounds, which were based on all-ferrous [Fe4S4]0 [18].
3. Catalysis by Fe-NHC complexes: important transformations
Even if there are a tremendous number of catalysts based on rare/heavy transition metals such as palladium, platinum, ruthenium, rhodium, iridium, and gold [28, 29, 30] are available for various different kind of organic transformations and they are very successful; the scientific community is trying hard to replace these metals by some environment and biological friendly metals because they are highly expensive and very toxic in nature therefore not compatible with biological systems. Iron becomes the obvious choice since it is the most abundant transition metal on the earth’s crust, relatively inexpensive, environmentally benign [31] and relatively less toxic to the biological systems [32, 33]. There are several very successful examples of iron-based catalysts like Fischer-Tropsch and the Haber-Bosch processes [34] and are capable of catalysis in numerous different reactions [35, 36]. Reports related to the iron-NHC complexes started coming just after the publication of first metal-NHC complex in 1968, the growth in the research was almost ceased for next three decades and picks up the pace after the success of Grubb’s catalyst for various organic transformations and polymerization reactions [20, 37]. Iron-NHC complexes are reported to have found applications in different classes of reactions such as substitution, addition, oxidation, reduction, cycloaddition, isomerization, rearrangement and polymerization reactions (Figure 11).
Figure 11.
Important transformations catalyzed by Fe-NHC complexes.
3.1 C-C bond formations
Negishi, Suzuki, and Heck were awarded the Nobel Prize in 2010 for their pioneer work in the area of cross-coupling reactions, as it provides a very effective tool for C-C bond formation. Several different protocols have been reported mainly based on palladium and, to some extent, Ni and copper metal ions. Iron-NHC complex based catalysts have been used for various Kumada-type cross-couplings such as C(sp3)-C(sp2), C(sp2)-C(sp3), C(sp2)-C(sp2), C(sp3)-C(sp3) bond formations, and C(sp2)-C(sp2) homo-couplings. NHC can either be generated in situ in a reaction or a resynthesized iron-NHC complex can be used. Bedford and co-workers, in a first, introduced the NHCs ligands and iron-NHC complexes along with FeCl3 to improve the yield of Kumada-type coupling reactions (Figure 12A) [38]. Among several carbene ligand precursors, tert-butylimidazolinium chloride 12a was found to give the best results (97% yield) and the performance was almost matched by the iron-NHC complex 12 (94% yield).
The proposed mechanism suggests that reaction does not follow the classical oxidative addition mechanism, but rather involves a radical intermediate produced through single electron transfer (SET) (Figure 12B) [39, 40]. Reaction mechanism involves the following processes: (i) generation of active catalyst through reduction of Fe(III) to Fe(II, I, or 0), (ii) generation and association (not the oxidative addition) of alkyl radical (R.) with the iron center through SET, (iii) transmetalation, where aryl group is transferred from ArMgX to the iron center, and (iv) attack of alkyl radical (R.) to the aryl group (Ar) leading to the generation of coupled product and the catalyst [38].
It was proved through a control experiment that particularly primary and secondary alkyl halides favor iron-catalyzed reactions, in comparison to most of the Pd or Ni systems, because of their sluggish tendency toward the β-hydride elimination and hence less susceptibility to the olefin formation. Therefore, it plausibly indicated the limitations of the catalytic role of the Fe-NHC complexes, in case of in situ formation of an iron NHC complex or the deprotonation of the imidazolium salt. Besides Alkyl bromide, dinuclear Fe-NHC imido complexes such as 13 have been reported to be effective in activating other alkyl halides and most challenging alkyl fluoride (Figure 13A). Here again, the use of the substrates such as (fluoromethyl)cyclopropane suggested a radical-mediated mechanistic pathway (Figure 13B). The first step is the dissociation of one NHC ligand followed by the second step as transmetalation (note: dinuclear iron imido subunit stays intact during the process). The further mechanism involves the usual mechanistic protocol, which includes firstly the formation of radical species and secondly, attack of the radical on the aryl moiety [21]. Several more iron-NHC complex catalyzed carbon-carbon coupling reactions have been given in Table 1.
Other examples of C-C bond formation and allylic alkylation reactions [41, 42, 43, 44].
3.2 Allylic alkylations
In a seminal work by Plietker group [19], allylic alkylation by the catalyst 14 was shown through the reaction of allyl carbonate and a Michael donor resulting into two isomeric products, i.e. (i) Product X, through the ipso substitution, and (ii) Product Y, via a σ−π−σ isomerization (Figure 14A). Mechanistic investigation suggests that the product ratio is greatly influenced by the steric crowd around the metal center, created due to the substituents on the nitrogen atoms of NHC moiety. Increased steric crowd hinders the isomerization process and thus favoring ipso substitution product X. For example, if tert-butyl group is present on the N atom of NHC, ipso substitution is favored, on the other hand, mesitylene group, which creates less steric hindrance around the metal center, favors isomerized product Y. In addition, stronger nucleophilicity of Michael donor favors the ipso-substitution. A plausible mechanism is outlined in Figure 14B. Few more allylic alkylation reactions are presented in Table 1.
Catalytic C-H bond activation has been one of the major tools to perform effective chemical transformations. Applicability of Fe-NHC complex as the catalyst for C-H bond activation has gained momentum since it can produce the formation of a range of different C-X bonds such as C-N, C-B, C-Mg, and C-S bond. Fe-NHC complex catalyzed C-N bond formation is important because of the three very basic reasons, (a) aziridine based compounds are of medicinal importance and therefore essential for pharmaceutical industry, (b) demand of aziridine derivatives in polymer chemistry as cross-linker agents for two-component resins, and (c) relative to well-known synthesis of O-epoxidation analogs, it is hard to synthesize the designer N-building blocks. Catalytic aziridination of alkenes by using Fe-NHC complex 15(0.1–1 mol%) as the catalyst was published by Jenkins et al. [24] to form respective aryl-substituted aziridines by treating aryl azides with various substituted alkene (Figure 15A). As proposed, the reaction involved the formation of a key and highly reactive intermediate Fe(IV) imido complex (Figure 15B). Few more C-X bond formation reactions are presented in Table 2.
Figure 15.
(A) Fe-NHC catalyzed aziridination of alkenes [24]; (B) proposed mechanism.
Table 2.
Other examples of C-X bond formations [23, 45, 46, 47, 48, 49, 50].
3.4 Reduction reactions
There are several reports on the reduction of alkenes via silylation using iron-NHC complexes. Royo group was first to show such conversion using piano stool type complex 16 (Figure 16A) [25]. The reaction is sensitive to the type of substituent present at para-position in the aromatic ring of the reactant, e.g. quantitative yields for reactions of p-aryl-substituted aldehydes and alkyl-substituted aldehydes or ketones remained unreactive. Another piano stool type complex 17 reduces ketones and aldehydes into the corresponding alcohols very efficiently (Figure 16B) [26]. Same catalyst 17 can reduce the carbonyl group of various amides in moderate to excellent yields (Figure 16C and D) [27]. In both cases, irradiation of visible light is crucial for the reported effective conversions, where PhSiH3 works as the hydride source. Catalyst shows differential reactivity with the primary, secondary and tertiary amides. Secondary and tertiary amides give usual conversion of carbonyl group into alcohol, while primary amide converts into nitrile compound. Cyclic amides have to be protected before reduction; otherwise a mixture of products forms. Various recently reported iron-NHC complex catalyzed reduction reactions are summarized in Table 3.
Figure 16.
Hydrosilylative reductions of (A) benzaldehyde derivatives [25]; (B and C) substituted and primary amides, respectively [27].
Table 3.
Other examples of reduction reactions [53, 54, 55, 56, 57, 58, 59, 60].
3.5 Cyclization reactions
Fe-NHC catalyzed ring expansion of the epoxides with functionalized alkenes presents a very intriguing case because cyclic structures are of great importance in various fields such as the pharmaceutical industry, fine chemicals, agriculture, etc. Fe-NHC catalyzed such reactions not only have shown functional group tolerance but also high chemo- and regioselectivity.
Hilt et al. [51] used a mixture of FeCl2, phosphine ligands and in situ generated free NHCs, 18 and performed reaction under reductive conditions using Zn and NEt3 (Figure 17A). The reaction mechanism demonstrates the first step as a SET (single-electron transfer) in epoxide ring-opening, the second step as the formation of an elongated alkoxy radical via reaction between formed radical intermediate and added alkene, and the final step as a BET (back-electron transfer), which gave the desired expanded cyclic product via a zwitterionic intermediate cyclization (Figure 17B).
Figure 17.
(A) Fe-NHC catalyzed epoxide ring expansions [51]; (B) proposed mechanism.
3.6 Polymerization
So far, the application of Fe-NHC complexes have not been much explored in the area of polymerization [52]. Grubbs has first reported the use of Fe-NHC complex 19 as the catalyst in atom transfer radical polymerization (ATRP) reaction of styrene and methyl methacrylate (Figure 18) [20]. The reaction shows pseudo first-order kinetics, a decent control of radical concentration, and polydispersity index (PDI) near 1.1.
Figure 18.
Atom transfer radical polymerization (ATRP) of olefins [20].
Shen and co-workers have reported the ring-opening polymerization (ROP) reaction of ε-caprolactone by using Fe-NHC complex 20 as the catalyst [22]. Even though reaction suffers some side reaction of transesterification, polymerization progresses with quantitative conversion and moderate number average molecular weight distribution (Figure 19).
Figure 19.
Ring-opening polymerization of ε-caprolactone [22].
4. Conclusion
Iron will remain a metal of choice for the replacement of all the heavy metal ions currently being used for the application of catalytic processes for the obvious reason of it being economical, very high natural abundance, environmentally benign and more importantly biologically compatible. Earlier, several iron-based complexes have enjoyed their success in many processes like Fischer−Tropsch and the Haber−Bosch processes, but the progress of iron-NHC complexes has gained momentum only after the success of Grubb’s catalyst at the onset of this century and now the number of published articles is growing with every passing year. The importance of Fe-NHC complexes can be evaluated from the aforementioned fact that they have found applicability in diverse fields from academia (e.g. biomimetic studies, various intriguing chemical transformations) to industries (e.g. pharmaceutical industry). The existing and ever possible versatility of (i) various structural motifs with different oxidation states, (ii) their flexible coordination geometries before and after the reaction, and (iii) substitution patterns in the iron N-heterocyclic carbene complexes along with their potential economic and toxicity benefits present an exciting scenario for the upcoming generation.
Acknowledgments
Badri Nath Jha is grateful to the SERB-DST (Project No. YSS/000699/2015), India, for the financial support to carry out research in the area of catalysis and cathodic materials of LIBs. B.N. Jha is also thankful to Pradeep Mathur for his continuous motivation to write book chapters/books and pursue research. Abhinav Raghuvanshi is thankful to the SERB for NPDF fellowship file no. PDF/2016/001786 for the financial support to carry out the research.
Conflict of interest
Authors have no conflict of interests to declare.
\n',keywords:"N-heterocyclic carbene (NHC), singlet carbenes, triplet carbenes, percent buried volume (% Vbur), σ-donation, π-donation, CO complexes, NO complexes, halide complexes, donor-substituted NHCs, pincer motifs, scorpionato motifs, macrocyclic ligands, piano stool motifs, iron-sulfur clusters, C-C bond formations, allylic alkylations, C-X (heteroatom) bond formations, reduction reactions, cyclization reactions, polymerization",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/71183.pdf",chapterXML:"https://mts.intechopen.com/source/xml/71183.xml",downloadPdfUrl:"/chapter/pdf-download/71183",previewPdfUrl:"/chapter/pdf-preview/71183",totalDownloads:883,totalViews:0,totalCrossrefCites:0,dateSubmitted:"May 2nd 2019",dateReviewed:"November 25th 2019",datePrePublished:"March 9th 2020",datePublished:"May 27th 2020",dateFinished:"February 20th 2020",readingETA:"0",abstract:"Recent research towards development of more efficient as well as cost effective catalyst as a substitute to traditional precious metal catalysts has witnessed significant growth and interest. Importance has been given to catalyst based on 3d-transition metals, especially iron because of the broad availability and environmental compatibility which allows its use in various environmentally friendly catalytic processes. N-Heterocyclic carbene (NHC) ligands have garnered significant attention because of their unique steric and electronic properties which provide substantial scope and potential in organometallic chemistry, catalysis and materials sciences. In the context of catalytic applications, iron-NHC complexes have gained increasing interest in the past two decades and could successfully be applied as catalysts in various homogeneous reactions including C–C couplings (including biaryl cross-coupling, alkyl-alkyl cross-coupling, alkyl-aryl cross-coupling), reductions and oxidations. In addition to this, iron-NHC complexes have shown the ability to facilitate a variety of reactions including C-heteroatom bond formation reactions, hydrogenation and transfer-hydrogenation reactions, polymerization reactions, etc. In this chapter, we will discuss briefly recent advancements in the catalytic activity of iron-NHC complexes including mono-NHC, bis-NHC (bidentate), tripodal NHC and tetrapodal NHC ligands. We have chosen iron-NHC complexes because of the plethora of publications available, increasing significance, being more readily available, non-toxic and economical.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/71183",risUrl:"/chapter/ris/71183",signatures:"Badri Nath Jha, Nishant Singh and Abhinav Raghuvanshi",book:{id:"9197",type:"book",title:"Organic Synthesis",subtitle:"A Nascent Relook",fullTitle:"Organic Synthesis - A Nascent Relook",slug:"organic-synthesis-a-nascent-relook",publishedDate:"May 27th 2020",bookSignature:"Belakatte Parameshwarappa Nandeshwarappa",coverURL:"https://cdn.intechopen.com/books/images_new/9197.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-78985-944-7",printIsbn:"978-1-78985-943-0",pdfIsbn:"978-1-83880-626-2",isAvailableForWebshopOrdering:!0,editors:[{id:"261141",title:"Dr.",name:"Belakatte Parameshwarappa",middleName:null,surname:"Nandeshwarappa",slug:"belakatte-parameshwarappa-nandeshwarappa",fullName:"Belakatte Parameshwarappa Nandeshwarappa"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"262712",title:"Dr.",name:"Badri Nath",middleName:null,surname:"Jha",fullName:"Badri Nath Jha",slug:"badri-nath-jha",email:"bnjha06@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Indian Institute of Technology Bombay",institutionURL:null,country:{name:"India"}}},{id:"298775",title:"Dr.",name:"Abhinav",middleName:null,surname:"Raghuvanshi",fullName:"Abhinav Raghuvanshi",slug:"abhinav-raghuvanshi",email:"r.abhinav@iiti.ac.in",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"314590",title:"Dr.",name:"Nishant",middleName:null,surname:"Singh",fullName:"Nishant Singh",slug:"nishant-singh",email:"intelnishant@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Tilka Manjhi Bhagalpur University",institutionURL:null,country:{name:"India"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 Structure and general properties of NHCs",level:"2"},{id:"sec_2_2",title:"1.2 Synthesis of NHCs precursor and generation of carbene",level:"2"},{id:"sec_3_2",title:"1.3 Generation of NHCs",level:"2"},{id:"sec_4_2",title:"1.4 Coordination of NHCs to transition metals",level:"2"},{id:"sec_5_2",title:"1.5 Phosphine versus NHCs",level:"2"},{id:"sec_7",title:"2. Various motifs of Fe-NHC complexes",level:"1"},{id:"sec_7_2",title:"2.1 Mono- and bis-(mono- or chelating) carbene ligands",level:"2"},{id:"sec_7_3",title:"2.1.1 CO complexes",level:"3"},{id:"sec_8_3",title:"2.1.2 NO complexes",level:"3"},{id:"sec_9_3",title:"2.1.3 Halide complexes",level:"3"},{id:"sec_11_2",title:"2.2 Donor-substituted NHCs",level:"2"},{id:"sec_12_2",title:"2.3 Pincer motifs",level:"2"},{id:"sec_13_2",title:"2.4 Scorpionato motifs",level:"2"},{id:"sec_14_2",title:"2.5 Macrocyclic ligands",level:"2"},{id:"sec_15_2",title:"2.6 Piano stool motifs",level:"2"},{id:"sec_16_2",title:"2.7 Iron-sulfur clusters",level:"2"},{id:"sec_18",title:"3. Catalysis by Fe-NHC complexes: important transformations",level:"1"},{id:"sec_18_2",title:"3.1 C-C bond formations",level:"2"},{id:"sec_19_2",title:"3.2 Allylic alkylations",level:"2"},{id:"sec_20_2",title:"3.3 C-X (heteroatom) bond formations",level:"2"},{id:"sec_21_2",title:"3.4 Reduction reactions",level:"2"},{id:"sec_22_2",title:"3.5 Cyclization reactions",level:"2"},{id:"sec_23_2",title:"3.6 Polymerization",level:"2"},{id:"sec_25",title:"4. Conclusion",level:"1"},{id:"sec_26",title:"Acknowledgments",level:"1"},{id:"sec_29",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Arduengo AJ III, Harlow RL, Kline MA. Stable crystalline carbene. Journal of the American Chemical Society. 1991;113:36-363. DOI: 10.1021/ja00001a054. This is the first report of a stable, isolable NHC'},{id:"B2",body:'de Fre’mont P, Marion N, Nolan SP. Carbenes: Synthesis, properties, and organometallic chemistry. Coordination Chemistry Reviews. 2009;253:862-892. 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Principles of Bioinorganic Chemistry. Mill Valley, CA: University Science Books; 1994. ISBN: 0-935702-73-3'},{id:"B33",body:'Ochiai EI. Bioinorganic Chemistry: A Survey. Amsterdam: Elsevier Science/Academic Press; 2010. ISBN: 978-0-120-88756-9'},{id:"B34",body:'Beller M, Renken A, van Santen RA. Catalysis: From Principles to Applications. Weinheim, Germany: Wiley-VCH; 2012. ISBN: 978-3-527-32349-4'},{id:"B35",body:'Gopalaiah K. Chiral iron catalysts for asymmetric synthesis. Chemical Reviews. 2013;113:3248-3296. DOI: 10.1021/cr300236r'},{id:"B36",body:'Plietker B. Iron Catalysis in Organic Chemistry: Reactions and Applications. Weinheim, Germany: Wiley-VCH; 2008. ISBN: 978-3-527-31927-5'},{id:"B37",body:'Lavallo V, El-Batta A, Bertrand G, Grubbs RH. Insights into the carbene-initiated aggregation of [Fe(cot)2]. Angewandte Chemie, International Edition. 2011;50:268-271. DOI: 10.1002/anie.201005212'},{id:"B38",body:'Bedford RB, Betham M, Bruce DW, Danopoulos AA, Frost RM, Hird M. Iron-phosphine, -phosphite, -arsine, and -carbene catalysts for the coupling of primary and secondary alkyl halides with aryl grignard reagents. The Journal of Organic Chemistry. 2006;71:1104-1110. DOI: 10.1021/jo052250+'},{id:"B39",body:'Nakamura M, Matsuo K, Ito S, Nakamura E. Iron-catalyzed cross-coupling of primary and secondary alkyl halides with aryl grignard reagents. Journal of the American Chemical Society. 2004;126:3686-3687. DOI: 10.1021/ja049744t'},{id:"B40",body:'Martin R, Fürstner A. Cross-coupling of alkyl halides with aryl Grignard reagents catalyzed by a low-valent iron complex. Angewandte Chemie, International Edition. 2004;43:3955-3957. DOI: 10.1002/anie.200460504'},{id:"B41",body:'Silberstein AL, Ramgren SD, Garg NK. Iron-catalyzed alkylations of aryl sulfamates and carbamates. Organic Letters. 2012;14:3796-3799. DOI: 10.1021/ol301681z'},{id:"B42",body:'Hatakeyama T, Nakamura M. 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ChemCatChem. 2012;4:329-332. DOI: 10.1002/cctc.201100465'},{id:"B51",body:'Hilt G, Bolze P, Kieltsch I. An iron-catalysed chemo- and regioselective tetrahydrofuran synthesis. Chemical Communications. 2005:1996-1998. DOI: 10.1039/B501100K'},{id:"B52",body:'Pintauer T, Matyjaszewski K. Atom transfer radical addition and polymerization reactions catalyzed by PPM amounts of copper complexes. Chemical Society Reviews. 2008;37:1087-1097. DOI: 10.1039/B714578K'},{id:"B53",body:'Bézier D, Jiang F, Roisnel T, Sortais J-B, Darcel C. Cyclopentadienyl-NHC iron complexes for solvent-free catalytic hydrosilylation of aldehydes and ketones. European Journal of Inorganic Chemistry. 2012;2012:1333-1337. DOI: 10.1002/ejic.201100762'},{id:"B54",body:'Grohmann C, Hashimoto T, Fröhlich R, Ohki Y, Tatsumi K, Glorius F. An Iron(II) complex of a diamine-bridged bis-N-heterocyclic carbene. Organometallics. 2012;31:8047-8050. DOI: 10.1021/om300888q'},{id:"B55",body:'Warratz S, Postigo L, Royo B. Direct synthesis of Iron (0) N-heterocyclic carbene complexes by using Fe3(CO)12 and their application in reduction of carbonyl groups. Organometallics. 2013;32:893-897. DOI: 10.1021/om3012085'},{id:"B56",body:'Bézier D, Venkanna GT, Misal Castro LC, Zheng J, Roisnel T, Sortais J-B, et al. Iron-catalyzed hydrosilylation of esters. Advanced Synthesis and Catalysis. 2012;354:1879-1884. DOI: 10.1002/adsc.201200087'},{id:"B57",body:'Demir S, Gökçe Y, Kaloğlu N, Sortais J-B, Darcel C, Özdemir İ. Synthesis of new Iron-NHC complexes as catalysts for hydrosilylation reactions. Applied Organometallic Chemistry. 2013;27:459-464. DOI: 10.1002/aoc.3006'},{id:"B58",body:'Li H, Misal Castro LC, Zheng J, Roisnel T, Dorcet V, Sortais J-B, et al. Selective reduction of esters to aldehydes under the catalysis of well-defined NHC-Iron complexes. Angewandte Chemie, International Edition. 2013;52:8045-8049. DOI: 10.1002/anie.201303003'},{id:"B59",body:'Volkov A, Buitrago E, Adolfsson H. Direct hydrosilylation of tertiary amides to amines by an in situ formed Iron/N-heterocyclic carbene catalyst. European Journal of Organic Chemistry. 2013:2066-2070. DOI: 10.1002/ejoc.201300010'},{id:"B60",body:'Misal Castro LC, Sortais J-B, Darcel C. NHC-carbene cyclopentadienyl iron based catalyst for a general and efficient hydrosilylation of imines. Chemical Communications. 2012;48:151-153. DOI: 10.1039/C1CC14403K'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Badri Nath Jha",address:"bnjha06@gmail.com",affiliation:'
University Department of Chemistry, T. M. Bhagalpur University, India
Department of Chemistry, Indian Institute of Technology Indore, India
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That fact is not surprising having in mind that they represent interconnected activities that complement each other and give each other completely new dimension. On one side, sports and health represent very important content of tourist offer because of the fact they enable tourists to become active participants in various activities, and on the other side, they represent important driving force for visiting particular destination. The idea of this chapter is to provide a theoretical and practical framework of this issue with a special focus on case study of Montenegro. According to the results of the research that was carried out, the general conclusion is that Montenegro has extremely valuable natural resources and potentials for the development of sports and health tourism, but there are still a lot of challenges that should be faced in the future in order to improve the quality of tourist offer and the level of tourists’ satisfaction as well as to create completely new image of the destination and position it as high-quality sports and health tourist destination on international market.",signatures:"Anđela Jakšić-Stojanović and Neven Šerić",authors:[{id:"306003",title:"Prof.",name:"Andjela",surname:"Jaksic-Stojanovic",fullName:"Andjela Jaksic-Stojanovic",slug:"andjela-jaksic-stojanovic",email:"andjela.jaksic@unimediteran.net"},{id:"310367",title:"Prof.",name:"Neven",surname:"Šerić",fullName:"Neven Šerić",slug:"neven-seric",email:"office@unimediteran.net"}],book:{id:"9158",title:"Sports Science and Human Health",slug:"sports-science-and-human-health-different-approaches",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"70691",title:"Prof.",name:"Gongbing",surname:"Shan",slug:"gongbing-shan",fullName:"Gongbing Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"129681",title:"Dr.",name:"Mamun Bin Ibne",surname:"Reaz",slug:"mamun-bin-ibne-reaz",fullName:"Mamun Bin Ibne Reaz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/129681/images/system/129681.jfif",biography:"Mamun Bin Ibne Reaz was born in Bangladesh, in December 1963. He received his B.Sc. and M.Sc. degree in Applied Physics and Electronics, both from University of Rajshahi, Bangladesh, in 1985 and 1986, respectively. He received his D.Eng. degree in 2007 from Ibaraki University, Japan. He is currently a Professor in the Department of Electrical, Electronic and Systems Engineering, Universiti Kebangsaan Malaysia, Malaysia involved in teaching, research and industrial consultation. He is a Senior Associate of the Abdus Salam International Centre for Theoretical Physics (ICTP), Italy since 2008. He is also a Senior Member of IEEE. He has published extensively in the area of IC Design, Biomedical application IC and Smart Home. He is author and coauthor of more than 300 research articles in design automation, IC design for biomedical applications and Smart Home. He is also the recipient of more than 50 research grants (national and international).",institutionString:"National University of Malaysia",institution:{name:"National University of Malaysia",institutionURL:null,country:{name:"Malaysia"}}},{id:"244639",title:"Dr.",name:"Muhammad E.H.",surname:"Chowdhury",slug:"muhammad-e.h.-chowdhury",fullName:"Muhammad E.H. Chowdhury",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Qatar University",institutionURL:null,country:{name:"Qatar"}}},{id:"245398",title:"MSc.",name:"Amith M. A.",surname:"Khandakar",slug:"amith-m.-a.-khandakar",fullName:"Amith M. A. 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He received his M.S. in Management/Marketing and his B.S. Sports Science/Business from Lasell University where he lectures in their School of Business. Chris is the co-owner of Boston Strength and Conditioning where he coaches athletes around the world from a range of sports. He is also a consultant for start-ups in the fields of medical technology, technology, health & fitness. His main research interests are human performance, leadership, and gamification. He is the co-editor chief of the Journal of Marketing Communications for Higher Education and a Medical Services Officer in the U.S. Army National Guard.",institutionString:null,institution:null},{id:"306398",title:"Dr.",name:"Marko",surname:"Kos",slug:"marko-kos",fullName:"Marko Kos",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Maribor",institutionURL:null,country:{name:"Slovenia"}}},{id:"308043",title:"Prof.",name:"Tegwen",surname:"Gadais",slug:"tegwen-gadais",fullName:"Tegwen Gadais",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Quebec at Montreal",institutionURL:null,country:{name:"Canada"}}},{id:"309519",title:"Dr.",name:"Iztok",surname:"Kramberger",slug:"iztok-kramberger",fullName:"Iztok Kramberger",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Maribor",institutionURL:null,country:{name:"Slovenia"}}},{id:"310367",title:"Prof.",name:"Neven",surname:"Šerić",slug:"neven-seric",fullName:"Neven Šerić",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Split",institutionURL:null,country:{name:"Croatia"}}}]},generic:{page:{slug:"authorship-policy",title:"Authorship Policy",intro:'
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Substantially contribute to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work
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All contributors who meet these criteria are listed as Authors. Their exact contributions should be described in the manuscript at the time of submission.
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CHANGES IN AUTHORSHIP
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If it is felt necessary to make changes to the list of Authors after a manuscript has been submitted or published, it is the responsibility of the Author concerned to provide a valid reason to amend the published list. Additionally, all listed Authors must verify and approve the proposed changes in order for any amendments to be made.
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AFFILIATION
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Authors are responsible for ensuring all addresses and emails provided are correct. Under affiliation(s) all Authors should indicate where the research was conducted. Please note that no changes to the affiliation(s) can be made after the chapter has been published.
Substantially contribute to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work
\n\t
Participate in drafting or revising the work
\n\t
Approve the final version of the work to be published.
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All contributors who meet these criteria are listed as Authors. Their exact contributions should be described in the manuscript at the time of submission.
\n\n
Conversely, all contributors who do not meet these criteria should be listed in the Acknowledgments section of the manuscript, along with a short description of their specific contributions.
\n\n
CHANGES IN AUTHORSHIP
\n\n
If it is felt necessary to make changes to the list of Authors after a manuscript has been submitted or published, it is the responsibility of the Author concerned to provide a valid reason to amend the published list. Additionally, all listed Authors must verify and approve the proposed changes in order for any amendments to be made.
\n\n
AFFILIATION
\n\n
Authors are responsible for ensuring all addresses and emails provided are correct. Under affiliation(s) all Authors should indicate where the research was conducted. Please note that no changes to the affiliation(s) can be made after the chapter has been published.
\n\n
Policy last updated: 2017-05-29
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
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\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
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\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n
\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
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He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. 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