\r\n\tDiagnosis (clinical, radiological, cytogenetic, and molecular criteria), pathogenesis (risk factors, pre-myeloma conditions, and bone marrow microenvironment), cytogenetic abnormalities and molecular profiles disease staging and risk stratification, novel therapies such as proteasome inhibitors, immunomodulatory agents as well as monoclonal antibodies, drug resistance (primary and secondary resistance as well as evolution of new genetic mutations that may be disease or therapy-related), hematopoietic stem cell transplantation (HSCT) (autologous HSCT, allogeneic HSCT, and tandem transplantation), relapsed and refractory multiple myeloma, minimal residual disease (evaluation by flow cytometry or various sequencing techniques, importance of MRD in prognosis and prediction of disease relapse), chimeric antigen receptor (CAR) T-cell therapy, infectious complications in multiple myeloma (viral infections, bacterial infections, fungal infections, disease-related infections and therapy-related infections).
\r\n\r\n\tThe book chapters will intend to be written by scientists and experts in the field from various institutions around the world.
",isbn:"978-1-80356-093-9",printIsbn:"978-1-80356-092-2",pdfIsbn:"978-1-80356-094-6",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"c8e2b12df4fc2d313aced448fe08a63e",bookSignature:"Dr. Khalid Ahmed Al-Anazi",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11600.jpg",keywords:"Risk Factors, Angiogenesis, Signaling Pathways, Therapeutic Targets, Drug Resistance, Genetic Mutations, Disease-Related Infections, Therapy-Related Infections, Complete Remission, Overall Survival, Immunomodulatory Agents, Bone Marrow Microenvironment",numberOfDownloads:13,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"January 26th 2022",dateEndSecondStepPublish:"March 29th 2022",dateEndThirdStepPublish:"May 28th 2022",dateEndFourthStepPublish:"August 16th 2022",dateEndFifthStepPublish:"October 15th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dr. Khalid Al-Anazi established the Hematopoietic Stem Cell Transplantation Services in Saudi Arabia. He is a distinguished researcher in the fields of stem cell therapies & infections in immunocompromised individuals.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"37255",title:"Dr.",name:"Khalid",middleName:"Ahmed",surname:"Al-Anazi",slug:"khalid-al-anazi",fullName:"Khalid Al-Anazi",profilePictureURL:"https://mts.intechopen.com/storage/users/37255/images/system/37255.jpg",biography:"Dr. Khalid Ahmed Al-Anazi is a consultant Hemato-Oncologist and the Chairman of the Department of Adult Hematology and Hematopoietic Stem Cell Transplantation (HSCT) at King Fahad Specialist Hospital (KFSH) in Dammam, Saudi Arabia. \r\nHe graduated from the college of medicine, King Saud University (KSU) in Riyadh in 1986. After having his Boards in Internal Medicine, he trained in clinical hematology and HSCT at King’s College Hospital, University of London, U.K. He has 4 year experience in internal medicine and 28 year experience in adult clinical hematology and HSCT at: Riyadh Armed Forces Hospital; King Faisal Specialist Hospital and Research Centre (KFSH&RC) in Riyadh; King Khalid University Hospital (KKUH) and the College of Medicine, KSU in Riyadh; and KFSH in Dammam, Saudi Arabia. \r\nHe established the adult HSCT program at KFSH in Dammam in the year 2010. He received the award of the best teacher in the Department of Medicine, at the College of Medicine and KKUH in Riyadh in the year 2014. \r\n\r\nHe has more than 95 publications including retrospective studies, review articles, book chapters, and electronic books and he is a reviewer for 25 international medical journals. \r\nHe is the Editor-in-Chief of the Journal of Stem Cell Biology and Transplantation and the Journal of Molecular Genetics and Medicine in addition to being Associate Editor for 26 other medical journals in HSCT, hematology, cancer and infectious diseases. \r\nHe is a member of several international organizations including ECIL (European Conference of Infections in Leukemia).",institutionString:"King Fahad Specialist Hospital",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"10",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"King Fahad Specialist Hospital",institutionURL:null,country:{name:"Saudi Arabia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:[{id:"82492",title:"Treatment of Patients with Newly-Diagnosed Multiple Myeloma",slug:"treatment-of-patients-with-newly-diagnosed-multiple-myeloma",totalDownloads:3,totalCrossrefCites:0,authors:[null]},{id:"82258",title:"Management of Renal Failure in Multiple Myeloma",slug:"management-of-renal-failure-in-multiple-myeloma",totalDownloads:11,totalCrossrefCites:0,authors:[null]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"429341",firstName:"Paula",lastName:"Gavran",middleName:null,title:"Ms.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"paula@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"8026",title:"Update on Mesenchymal and Induced Pluripotent Stem Cells",subtitle:null,isOpenForSubmission:!1,hash:"48115afa72bcce1bde1e5b0e6c45f1b8",slug:"update-on-mesenchymal-and-induced-pluripotent-stem-cells",bookSignature:"Khalid Ahmed Al-Anazi",coverURL:"https://cdn.intechopen.com/books/images_new/8026.jpg",editedByType:"Edited by",editors:[{id:"37255",title:"Dr.",name:"Khalid",surname:"Al-Anazi",slug:"khalid-al-anazi",fullName:"Khalid Al-Anazi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6710",title:"Update on Multiple Myeloma",subtitle:null,isOpenForSubmission:!1,hash:"229a96a2de131b3ac67f9f41b91de8f8",slug:"update-on-multiple-myeloma",bookSignature:"Khalid Ahmed Al-Anazi",coverURL:"https://cdn.intechopen.com/books/images_new/6710.jpg",editedByType:"Edited by",editors:[{id:"37255",title:"Dr.",name:"Khalid",surname:"Al-Anazi",slug:"khalid-al-anazi",fullName:"Khalid Al-Anazi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. Mauricio Barría",coverURL:"https://cdn.intechopen.com/books/images_new/6550.jpg",editedByType:"Edited by",editors:[{id:"88861",title:"Dr.",name:"R. Mauricio",surname:"Barría",slug:"r.-mauricio-barria",fullName:"R. Mauricio Barría"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9500",title:"Recent Advances in Bone Tumours and Osteoarthritis",subtitle:null,isOpenForSubmission:!1,hash:"ea4ec0d6ee01b88e264178886e3210ed",slug:"recent-advances-in-bone-tumours-and-osteoarthritis",bookSignature:"Hiran Amarasekera",coverURL:"https://cdn.intechopen.com/books/images_new/9500.jpg",editedByType:"Edited by",editors:[{id:"67634",title:"Dr.",name:"Hiran",surname:"Amarasekera",slug:"hiran-amarasekera",fullName:"Hiran Amarasekera"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"28628",title:"The Post-Reperfusion Syndrome (PRS): Diagnosis, Incidence and Management",doi:"10.5772/30124",slug:"the-post-reperfusion-syndrome-prs-diagnosis-incidence-and-management",body:null,keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/28628.pdf",chapterXML:null,downloadPdfUrl:"/chapter/pdf-download/28628",previewPdfUrl:"/chapter/pdf-preview/28628",totalDownloads:3508,totalViews:131,totalCrossrefCites:3,totalDimensionsCites:4,totalAltmetricsMentions:0,impactScore:3,impactScorePercentile:87,impactScoreQuartile:4,hasAltmetrics:0,dateSubmitted:"March 15th 2011",dateReviewed:"August 10th 2011",datePrePublished:null,datePublished:"February 15th 2012",dateFinished:null,readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/28628",risUrl:"/chapter/ris/28628",book:{id:"967",slug:"liver-transplantation-basic-issues"},signatures:"Kyota Fukazawa and Ernesto A. Pretto, Jr.",authors:[{id:"126448",title:"Prof.",name:"Ernesto",middleName:null,surname:"Pretto",fullName:"Ernesto Pretto",slug:"ernesto-pretto",email:"epretto@med.miami.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"174429",title:"Prof.",name:"Kyota",middleName:null,surname:"Fukazawa",fullName:"Kyota Fukazawa",slug:"kyota-fukazawa",email:"kyotaf@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Washington",institutionURL:null,country:{name:"United States of America"}}}],sections:null,chapterReferences:null,footnotes:null,contributors:null,corrections:null},book:{id:"967",type:"book",title:"Liver Transplantation",subtitle:"Basic Issues",fullTitle:"Liver Transplantation - Basic Issues",slug:"liver-transplantation-basic-issues",publishedDate:"February 15th 2012",bookSignature:"Hesham Abdeldayem and Naglaa Allam",coverURL:"https://cdn.intechopen.com/books/images_new/967.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:null,printIsbn:"978-953-51-0016-4",pdfIsbn:"978-953-51-6800-3",reviewType:"peer-reviewed",numberOfWosCitations:10,isAvailableForWebshopOrdering:!0,editors:[{id:"72383",title:"Prof.",name:"Hesham",middleName:null,surname:"Abdeldayem",slug:"hesham-abdeldayem",fullName:"Hesham Abdeldayem"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"108673",title:"Prof.",name:"Naglaa",middleName:null,surname:"Allam",slug:"naglaa-allam",fullName:"Naglaa Allam"},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1145"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"28611",type:"chapter",title:"History and Evolution of Liver Transplantation",slug:"history-and-evolution-of-liver-transplantation",totalDownloads:4589,totalCrossrefCites:0,signatures:"Ayman Azzam",reviewType:"peer-reviewed",authors:[{id:"99947",title:"Dr.",name:"Ayman",middleName:"Zaki",surname:"Azzam",fullName:"Ayman Azzam",slug:"ayman-azzam"}]},{id:"28612",type:"chapter",title:"Ischemia-Reperfusion Injury Associated with Liver Transplantation in 2011: Past and Future",slug:"ischemia-reperfusion-injury-associated-with-liver-transplantation-in-2011-past-and-future",totalDownloads:3120,totalCrossrefCites:0,signatures:"M. Elias-Miró, M.B. Jiménez-Castro and C. Peralta",reviewType:"peer-reviewed",authors:[{id:"74565",title:"Dr.",name:"Carmen",middleName:null,surname:"Peralta",fullName:"Carmen Peralta",slug:"carmen-peralta"},{id:"150567",title:"Dr.",name:"Maria",middleName:null,surname:"Elias-Miró",fullName:"Maria Elias-Miró",slug:"maria-elias-miro"},{id:"150568",title:"Dr.",name:"Mónica B.",middleName:null,surname:"Jiménez-Castro",fullName:"Mónica B. Jiménez-Castro",slug:"monica-b.-jimenez-castro"}]},{id:"28613",type:"chapter",title:"The Influences of Nitric Oxide on Liver Ischemia-Reperfusion Injury",slug:"the-influences-of-nitric-oxide-on-liver-ischemia-reperfusion-injury",totalDownloads:3150,totalCrossrefCites:0,signatures:"Erik Stoltenberg, Alexander A. Vitin, Bradley E. Hansen and John D. Lang, Jr.",reviewType:"peer-reviewed",authors:[{id:"46555",title:"Dr.",name:"Alexander",middleName:null,surname:"Vitin",fullName:"Alexander Vitin",slug:"alexander-vitin"},{id:"72340",title:"Dr.",name:"John",middleName:null,surname:"Lang Jr.",fullName:"John Lang Jr.",slug:"john-lang-jr."},{id:"84013",title:"Dr.",name:"Erik",middleName:null,surname:"Stoltenberg",fullName:"Erik Stoltenberg",slug:"erik-stoltenberg"},{id:"135933",title:"Dr.",name:"Bradley",middleName:"Evan",surname:"Hansen",fullName:"Bradley Hansen",slug:"bradley-hansen"}]},{id:"28614",type:"chapter",title:"Immunology of Liver Transplantation",slug:"immunology-of-liver-transplantation",totalDownloads:4983,totalCrossrefCites:1,signatures:"Ling Lu, Jianhua Rao, Guoqiang Li, Xiaofeng Qian, Beicheng Sun and Xuehao Wang",reviewType:"peer-reviewed",authors:[{id:"76797",title:"Prof.",name:"Ling",middleName:null,surname:"Lu",fullName:"Ling Lu",slug:"ling-lu"},{id:"131732",title:"Dr.",name:"Jianhua",middleName:null,surname:"Rao",fullName:"Jianhua Rao",slug:"jianhua-rao"},{id:"131735",title:"Dr.",name:"Guoqiang",middleName:null,surname:"Li",fullName:"Guoqiang Li",slug:"guoqiang-li"},{id:"131736",title:"Dr.",name:"Xiaofeng",middleName:null,surname:"Qian",fullName:"Xiaofeng Qian",slug:"xiaofeng-qian"},{id:"131738",title:"Prof.",name:"Beicheng",middleName:null,surname:"Sun",fullName:"Beicheng Sun",slug:"beicheng-sun"},{id:"131739",title:"Prof.",name:"Xuehao",middleName:null,surname:"Wang",fullName:"Xuehao Wang",slug:"xuehao-wang"},{id:"137464",title:"Dr.",name:"Xingli",middleName:null,surname:"Huang",fullName:"Xingli Huang",slug:"xingli-huang"}]},{id:"28615",type:"chapter",title:"Clinical Immunosuppression",slug:"clinical-immunosuppression",totalDownloads:2563,totalCrossrefCites:0,signatures:"Chunbao Guo",reviewType:"peer-reviewed",authors:[{id:"76767",title:"Prof.",name:"Chunbao",middleName:null,surname:"Guo",fullName:"Chunbao Guo",slug:"chunbao-guo"}]},{id:"28616",type:"chapter",title:"Prognostic Factors for Survival in Patients with Liver Cirrhosis",slug:"prognostic-factors-for-survival-in-patients-with-liver-cirrhosis",totalDownloads:6148,totalCrossrefCites:0,signatures:"Marcia Samada and Julio C. Hernández",reviewType:"peer-reviewed",authors:[{id:"81204",title:"Prof.",name:"Marcia",middleName:null,surname:"Samada Suarez",fullName:"Marcia Samada Suarez",slug:"marcia-samada-suarez"},{id:"85161",title:"Dr.",name:"Julio C.",middleName:null,surname:"Hernández",fullName:"Julio C. Hernández",slug:"julio-c.-hernandez"}]},{id:"28617",type:"chapter",title:"The Rise of Glutaminase in End-Stage Liver Diseases",slug:"the-rise-of-glutaminase-in-end-stage-liver-diseases",totalDownloads:3019,totalCrossrefCites:1,signatures:"Maria Jover-Cobos, Nathan Davies, Rajiv Jalan and Manuel Romero-Gómez",reviewType:"peer-reviewed",authors:[{id:"76894",title:"Dr.",name:"Maria",middleName:null,surname:"Jover-Cobos",fullName:"Maria Jover-Cobos",slug:"maria-jover-cobos"},{id:"130576",title:"Prof.",name:"Rajiv",middleName:null,surname:"Jalan",fullName:"Rajiv Jalan",slug:"rajiv-jalan"},{id:"130577",title:"Dr.",name:"Nathan",middleName:null,surname:"Davies",fullName:"Nathan Davies",slug:"nathan-davies"},{id:"130578",title:"Prof.",name:"Manuel",middleName:null,surname:"Romero-Gomez",fullName:"Manuel Romero-Gomez",slug:"manuel-romero-gomez"}]},{id:"28618",type:"chapter",title:"Disease Targeted Measures of Health Related Quality of Life (HRQOL) in Patients with Advanced Liver Disease Before and After Liver Transplantation",slug:"disease-targeted-measures-of-health-related-quality-of-life-hrqol-in-patients-with-advanced-liver-di",totalDownloads:3228,totalCrossrefCites:0,signatures:"Teresa Casanovas Taltavull, Maria Carmen Peña-Cala and Eva Rodríguez Bruzos",reviewType:"peer-reviewed",authors:[{id:"37764",title:"Dr",name:"Teresa",middleName:null,surname:"Casanovas",fullName:"Teresa Casanovas",slug:"teresa-casanovas"},{id:"150614",title:"Dr.",name:"Maria Carmen",middleName:null,surname:"Peña-Cala",fullName:"Maria Carmen Peña-Cala",slug:"maria-carmen-pena-cala"},{id:"150615",title:"Dr.",name:"Eva",middleName:null,surname:"Rodríguez Bruzos",fullName:"Eva Rodríguez Bruzos",slug:"eva-rodriguez-bruzos"}]},{id:"28619",type:"chapter",title:"Hepatitis C and Liver Transplantation",slug:"hepatitis-c-and-liver-transplantation",totalDownloads:2444,totalCrossrefCites:0,signatures:"Miguel Jiménez Pérez, Ana Belen Sáez Gómez, Rocío González Grande and Juan Miguel Rodrigo López",reviewType:"peer-reviewed",authors:[{id:"73568",title:"Dr.",name:"Miguel",middleName:null,surname:"Jiménez-Pérez",fullName:"Miguel Jiménez-Pérez",slug:"miguel-jimenez-perez"},{id:"74262",title:"Dr.",name:"Ana Belén",middleName:"Saez",surname:"Sáez-Gómez",fullName:"Ana Belén Sáez-Gómez",slug:"ana-belen-saez-gomez"},{id:"78000",title:"Dr.",name:"Rocío",middleName:null,surname:"González-Grande",fullName:"Rocío González-Grande",slug:"rocio-gonzalez-grande"},{id:"82946",title:"Dr.",name:"Juan Miguel",middleName:null,surname:"Rodrigo-López",fullName:"Juan Miguel Rodrigo-López",slug:"juan-miguel-rodrigo-lopez"}]},{id:"28620",type:"chapter",title:"HCV-Recurrence After Liver Transplantation",slug:"hcv-recurrence-after-liver-transplantation",totalDownloads:2214,totalCrossrefCites:0,signatures:"Dennis Eurich, Marcus Bahra and Peter Neuhaus",reviewType:"peer-reviewed",authors:[{id:"73987",title:"Dr",name:"Dennis",middleName:null,surname:"Eurich",fullName:"Dennis Eurich",slug:"dennis-eurich"},{id:"84098",title:"Dr.",name:"Marcus",middleName:null,surname:"Bahra",fullName:"Marcus Bahra",slug:"marcus-bahra"}]},{id:"28621",type:"chapter",title:"Management of Recurrent HCV and HBV Infections after Liver Transplantation",slug:"management-of-recurrent-hcv-and-hbv-infections-after-liver-transplantation",totalDownloads:1818,totalCrossrefCites:0,signatures:"Marta Wawrzynowicz-Syczewska",reviewType:"peer-reviewed",authors:[{id:"73585",title:"Prof.",name:"Marta",middleName:"Malgorzata",surname:"Wawrzynowicz-Syczewska",fullName:"Marta Wawrzynowicz-Syczewska",slug:"marta-wawrzynowicz-syczewska"}]},{id:"28622",type:"chapter",title:"Role of Liver Transplantation in Acute Liver Failure",slug:"role-of-liver-transplantation-in-acute-liver-failure",totalDownloads:2972,totalCrossrefCites:0,signatures:"Saleh A. Alqahtani1 and Anne M. Larson",reviewType:"peer-reviewed",authors:[{id:"80662",title:"Dr.",name:"Anne",middleName:"M",surname:"Larson",fullName:"Anne Larson",slug:"anne-larson"},{id:"81595",title:"Dr.",name:"Saleh",middleName:null,surname:"Alqahtani",fullName:"Saleh Alqahtani",slug:"saleh-alqahtani"}]},{id:"28623",type:"chapter",title:"Liver Transplantation for Hepatocellular Carcinoma (Hcc)",slug:"liver-transplantation-for-hepatocellular-carcinoma-hcc-",totalDownloads:5820,totalCrossrefCites:0,signatures:"Alejandro Mejia, Hector Nazario and Parvez Mantry",reviewType:"peer-reviewed",authors:[{id:"84140",title:"Dr.",name:"Alejandro",middleName:null,surname:"Mejia",fullName:"Alejandro Mejia",slug:"alejandro-mejia"},{id:"100406",title:"Dr.",name:"Parvez",middleName:"S",surname:"Mantry",fullName:"Parvez Mantry",slug:"parvez-mantry"},{id:"100413",title:"Dr.",name:"Hector",middleName:null,surname:"Nazario",fullName:"Hector Nazario",slug:"hector-nazario"}]},{id:"28624",type:"chapter",title:"Liver Transplantation Due to Abdominal Trauma",slug:"liver-transplantation-due-to-abdominal-trauma",totalDownloads:2348,totalCrossrefCites:0,signatures:"Matthias Heuer, Sven Lendemans, Gernot M. Kaiser and Andreas Paul",reviewType:"peer-reviewed",authors:[{id:"76991",title:"Dr.",name:"Matthias",middleName:null,surname:"Heuer",fullName:"Matthias Heuer",slug:"matthias-heuer"},{id:"84913",title:"Prof.",name:"Gernot",middleName:null,surname:"Kaiser",fullName:"Gernot Kaiser",slug:"gernot-kaiser"},{id:"91771",title:"Prof.",name:"Sven",middleName:null,surname:"Lendemans",fullName:"Sven Lendemans",slug:"sven-lendemans"},{id:"91772",title:"Prof.",name:"Andreas",middleName:null,surname:"Paul",fullName:"Andreas Paul",slug:"andreas-paul"}]},{id:"28625",type:"chapter",title:"Intensive Care Management of Patients Prior to Liver Transplantation",slug:"intensive-care-management-of-patients-prior-to-liver-transplantation",totalDownloads:2407,totalCrossrefCites:0,signatures:"Kathy M. Nilles and Ram M. Subramanian",reviewType:"peer-reviewed",authors:[{id:"74119",title:"Dr.",name:"Ram",middleName:null,surname:"Subramanian",fullName:"Ram Subramanian",slug:"ram-subramanian"},{id:"150572",title:"Dr.",name:"Kathy M.",middleName:null,surname:"Nilles",fullName:"Kathy M. Nilles",slug:"kathy-m.-nilles"}]},{id:"28626",type:"chapter",title:"Anesthesia in Liver Transplantation",slug:"anesthesia-in-liver-transplantation",totalDownloads:9655,totalCrossrefCites:1,signatures:"Meral Kanbak, Ayse Heves Karagoz and Filiz Üzümcügil",reviewType:"peer-reviewed",authors:[{id:"65030",title:"Prof.",name:"Meral",middleName:"-",surname:"Kanbak",fullName:"Meral Kanbak",slug:"meral-kanbak"},{id:"70552",title:"Dr.",name:"Filiz",middleName:null,surname:"Uzumcugil",fullName:"Filiz Uzumcugil",slug:"filiz-uzumcugil"},{id:"72972",title:"Associate Prof.",name:"Ayşe",middleName:"Heves",surname:"Karagöz",fullName:"Ayşe Karagöz",slug:"ayse-karagoz"}]},{id:"28627",type:"chapter",title:"Cardiovascular Monitoring and Substitution of the Blood Volume During Liver Transplantation",slug:"cardiovascular-monitoring-and-substitution-of-the-blood-volume-during-liver-transplantation",totalDownloads:2523,totalCrossrefCites:0,signatures:"Peter Nissen, Hans J. Frederiksen and Niels H. Secher",reviewType:"peer-reviewed",authors:[{id:"84421",title:"Mr.",name:"Peter",middleName:null,surname:"Nissen",fullName:"Peter Nissen",slug:"peter-nissen"},{id:"84788",title:"Mr.",name:"Hans J",middleName:null,surname:"Frederiksen",fullName:"Hans J Frederiksen",slug:"hans-j-frederiksen"},{id:"84792",title:"Mr.",name:"Niels H",middleName:null,surname:"Secher",fullName:"Niels H Secher",slug:"niels-h-secher"}]},{id:"28628",type:"chapter",title:"The Post-Reperfusion Syndrome (PRS): Diagnosis, Incidence and Management",slug:"the-post-reperfusion-syndrome-prs-diagnosis-incidence-and-management",totalDownloads:3508,totalCrossrefCites:3,signatures:"Kyota Fukazawa and Ernesto A. Pretto, Jr.",reviewType:"peer-reviewed",authors:[{id:"126448",title:"Prof.",name:"Ernesto",middleName:null,surname:"Pretto",fullName:"Ernesto Pretto",slug:"ernesto-pretto"},{id:"174429",title:"Prof.",name:"Kyota",middleName:null,surname:"Fukazawa",fullName:"Kyota Fukazawa",slug:"kyota-fukazawa"}]},{id:"28629",type:"chapter",title:"Malignant Hyperthermia in Liver Transplantation",slug:"malignant-hyperthermia-in-liver-transplantation",totalDownloads:2419,totalCrossrefCites:0,signatures:"Cláudia Regina Fernandes, David Silveira Marinho and Fernanda Paula Cavalcante",reviewType:"peer-reviewed",authors:[{id:"79438",title:"Prof.",name:"Claudia",middleName:null,surname:"Fernandes",fullName:"Claudia Fernandes",slug:"claudia-fernandes"},{id:"150570",title:"Dr.",name:"David",middleName:null,surname:"Silveira Marinho",fullName:"David Silveira Marinho",slug:"david-silveira-marinho"},{id:"150571",title:"Dr.",name:"Fernanda Paula",middleName:null,surname:"Cavalcante",fullName:"Fernanda Paula Cavalcante",slug:"fernanda-paula-cavalcante"}]}]},relatedBooks:[{type:"book",id:"3164",title:"Hepatic Surgery",subtitle:null,isOpenForSubmission:!1,hash:"e54bf2639e53e684ac2233e94ae53c19",slug:"hepatic-surgery",bookSignature:"Hesham Abdeldayem",coverURL:"https://cdn.intechopen.com/books/images_new/3164.jpg",editedByType:"Edited by",editors:[{id:"72383",title:"Prof.",name:"Hesham",surname:"Abdeldayem",slug:"hesham-abdeldayem",fullName:"Hesham Abdeldayem"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"42359",title:"General Introduction: Advances in Hepatic Surgery",slug:"general-introduction-advances-in-hepatic-surgery",signatures:"J.H.M.B. Stoot, R.J.S. Coelen, J.L.A. van Vugt and C.H.C. Dejong",authors:[{id:"157264",title:"Mr.",name:"Jan",middleName:null,surname:"Stoot",fullName:"Jan Stoot",slug:"jan-stoot"},{id:"157295",title:"Prof.",name:"Kees",middleName:null,surname:"Dejong",fullName:"Kees Dejong",slug:"kees-dejong"},{id:"181922",title:"Dr.",name:"Jeroen",middleName:null,surname:"Van Vugt",fullName:"Jeroen Van Vugt",slug:"jeroen-van-vugt"}]},{id:"42361",title:"Essential Functional Hepatic and Biliary Anatomy for the Surgeon",slug:"essential-functional-hepatic-and-biliary-anatomy-for-the-surgeon",signatures:"Ronald S. Chamberlain",authors:[{id:"67289",title:"Prof.",name:"Ronald",middleName:null,surname:"Chamberlain",fullName:"Ronald Chamberlain",slug:"ronald-chamberlain"}]},{id:"42362",title:"Anesthetic Considerations for Patients with Liver Disease",slug:"anesthetic-considerations-for-patients-with-liver-disease",signatures:"Aparna Dalal and John D. Jr. Lang",authors:[{id:"153090",title:"Dr.",name:"John",middleName:null,surname:"Lang",fullName:"John Lang",slug:"john-lang"}]},{id:"42855",title:"Critical Care Issues After Major Hepatic Surgery",slug:"critical-care-issues-after-major-hepatic-surgery",signatures:"Ashok Thorat and Wei-Chen Lee",authors:[{id:"52360",title:"Prof.",name:"Wei-Chen",middleName:null,surname:"Lee",fullName:"Wei-Chen Lee",slug:"wei-chen-lee"},{id:"157213",title:"Dr.",name:"Ashok",middleName:null,surname:"Thorat",fullName:"Ashok Thorat",slug:"ashok-thorat"}]},{id:"39211",title:"Strategies to Decrease Morbidity After Hepatectomy for Hepatocellular Carcinoma",slug:"strategies-to-decrease-morbidity-after-hepatectomy-for-hepatocellular-carcinoma",signatures:"Hiroshi Sadamori, Takahito Yagi and Toshiyoshi Fujiwara",authors:[{id:"40149",title:"Dr.",name:"Hiroshi",middleName:null,surname:"Sadamori",fullName:"Hiroshi Sadamori",slug:"hiroshi-sadamori"}]},{id:"41260",title:"Experimental Models in Liver Surgery",slug:"experimental-models-in-liver-surgery",signatures:"M.B. Jiménez-Castro, M. Elias-Miró, A. Casillas-Ramírez and C. Peralta",authors:[{id:"74565",title:"Dr.",name:"Carmen",middleName:null,surname:"Peralta",fullName:"Carmen Peralta",slug:"carmen-peralta"}]},{id:"42512",title:"The Aim of Technology During Liver Resection — A Strategy to Minimize Blood Loss During Liver Surgery",slug:"the-aim-of-technology-during-liver-resection-a-strategy-to-minimize-blood-loss-during-liver-surgery",signatures:"Fabrizio Romano, Mattia Garancini, Fabio Uggeri, Luca Gianotti, Luca Nespoli, Angelo Nespoli and Franco Uggeri",authors:[{id:"80710",title:"Dr.",name:"Fabrizio",middleName:null,surname:"Romano",fullName:"Fabrizio Romano",slug:"fabrizio-romano"},{id:"154931",title:"Dr.",name:"Mattia",middleName:null,surname:"Garancini",fullName:"Mattia Garancini",slug:"mattia-garancini"},{id:"165843",title:"Dr.",name:"Fabio",middleName:null,surname:"Uggeri",fullName:"Fabio Uggeri",slug:"fabio-uggeri"},{id:"165844",title:"Dr.",name:"Luca",middleName:null,surname:"Nespoli",fullName:"Luca Nespoli",slug:"luca-nespoli"},{id:"165845",title:"Dr.",name:"Luca",middleName:null,surname:"Gianotti",fullName:"Luca Gianotti",slug:"luca-gianotti"},{id:"165846",title:"Prof.",name:"Angelo",middleName:null,surname:"Nespoli",fullName:"Angelo Nespoli",slug:"angelo-nespoli"},{id:"165847",title:"Prof.",name:"Franco",middleName:null,surname:"Uggeri",fullName:"Franco Uggeri",slug:"franco-uggeri"}]},{id:"42364",title:"The Role of Ultrasound in Hepatic Surgery",slug:"the-role-of-ultrasound-in-hepatic-surgery",signatures:"Mattia Garancini, Luca Gianotti, Fabrizio Romano, Vittorio Giardini, Franco Uggeri and Guido Torzilli",authors:[{id:"80710",title:"Dr.",name:"Fabrizio",middleName:null,surname:"Romano",fullName:"Fabrizio Romano",slug:"fabrizio-romano"},{id:"154931",title:"Dr.",name:"Mattia",middleName:null,surname:"Garancini",fullName:"Mattia Garancini",slug:"mattia-garancini"},{id:"165845",title:"Dr.",name:"Luca",middleName:null,surname:"Gianotti",fullName:"Luca Gianotti",slug:"luca-gianotti"},{id:"165847",title:"Prof.",name:"Franco",middleName:null,surname:"Uggeri",fullName:"Franco Uggeri",slug:"franco-uggeri"},{id:"167454",title:"Dr.",name:"Vittorio",middleName:null,surname:"Giardini",fullName:"Vittorio Giardini",slug:"vittorio-giardini"},{id:"167455",title:"Dr.",name:"Guido",middleName:null,surname:"Torzilli",fullName:"Guido Torzilli",slug:"guido-torzilli"}]},{id:"42584",title:"Segmental Oriented Liver Surgery",slug:"segmental-oriented-liver-surgery",signatures:"O. Al-Jiffry Bilal and Khayat H. Samah",authors:[{id:"153686",title:"Dr.",name:"Bilal",middleName:null,surname:"Aljiffry",fullName:"Bilal Aljiffry",slug:"bilal-aljiffry"},{id:"165264",title:"Dr.",name:"Samah",middleName:null,surname:"Khayat",fullName:"Samah Khayat",slug:"samah-khayat"}]},{id:"42368",title:"Two-Step Hanging Maneuver for an Isolated Resection of the Dorsal Sector of the Liver",slug:"two-step-hanging-maneuver-for-an-isolated-resection-of-the-dorsal-sector-of-the-liver",signatures:"Hideaki Uchiyama, Shinji Itoh and Kenji Takenaka",authors:[{id:"72500",title:"Dr.",name:"Hideaki",middleName:null,surname:"Uchiyama",fullName:"Hideaki Uchiyama",slug:"hideaki-uchiyama"}]},{id:"38175",title:"Right Anterior Sectionectomy for Hepatocellular Carcinoma",slug:"right-anterior-sectionectomy-for-hepatocellular-carcinoma",signatures:"Hiromichi Ishii, Shimpei Ogino, Koki Ikemoto, Kenichi Takemoto, Atsushi Toma, Kenji Nakamura and Tsuyoshi Itoh",authors:[{id:"152937",title:"M.D.",name:"Hiromichi",middleName:null,surname:"Ishii",fullName:"Hiromichi Ishii",slug:"hiromichi-ishii"},{id:"152938",title:"Dr.",name:"Atsushi",middleName:null,surname:"Toma",fullName:"Atsushi Toma",slug:"atsushi-toma"},{id:"152939",title:"Dr.",name:"Tsuyoshi",middleName:null,surname:"Itoh",fullName:"Tsuyoshi Itoh",slug:"tsuyoshi-itoh"},{id:"152946",title:"Dr.",name:"Kenji",middleName:null,surname:"Nakamura",fullName:"Kenji Nakamura",slug:"kenji-nakamura"},{id:"164785",title:"Dr.",name:"Shimpei",middleName:null,surname:"Ogino",fullName:"Shimpei Ogino",slug:"shimpei-ogino"},{id:"164786",title:"Dr.",name:"Koki",middleName:null,surname:"Ikemoto",fullName:"Koki Ikemoto",slug:"koki-ikemoto"},{id:"164787",title:"Dr.",name:"Kenichi",middleName:null,surname:"Takemoto",fullName:"Kenichi Takemoto",slug:"kenichi-takemoto"}]},{id:"42369",title:"Benign Hepatic Neoplasms",slug:"benign-hepatic-neoplasms",signatures:"Ronald S. Chamberlain and Kim Oelhafen",authors:[{id:"67289",title:"Prof.",name:"Ronald",middleName:null,surname:"Chamberlain",fullName:"Ronald Chamberlain",slug:"ronald-chamberlain"}]},{id:"38417",title:"Surgical Management of Primary Hepatocellular Carcinoma",slug:"surgical-management-of-primary-hepatocellular-carcinoma",signatures:"Kun-Ming Chan and Ashok Thorat",authors:[{id:"157213",title:"Dr.",name:"Ashok",middleName:null,surname:"Thorat",fullName:"Ashok Thorat",slug:"ashok-thorat"},{id:"118007",title:"Dr.",name:"Kun-Ming",middleName:null,surname:"Chan",fullName:"Kun-Ming Chan",slug:"kun-ming-chan"}]},{id:"42779",title:"Liver Resection for Hepatocellular Carcinoma",slug:"liver-resection-for-hepatocellular-carcinoma",signatures:"Mazen Hassanain, Faisal Alsaif, Abdulsalam Alsharaabi and Ahmad Madkhali",authors:[{id:"160646",title:"Dr.",name:"Mazen",middleName:null,surname:"Hassanain",fullName:"Mazen Hassanain",slug:"mazen-hassanain"},{id:"160660",title:"Dr.",name:"Ahmad",middleName:null,surname:"Medkhali",fullName:"Ahmad Medkhali",slug:"ahmad-medkhali"},{id:"160661",title:"Dr.",name:"Faisal",middleName:null,surname:"Alsaif",fullName:"Faisal Alsaif",slug:"faisal-alsaif"},{id:"160662",title:"Dr.",name:"Abdusalam",middleName:null,surname:"Alsharabi",fullName:"Abdusalam Alsharabi",slug:"abdusalam-alsharabi"}]},{id:"42530",title:"Transplantation for Hepatocellular Carcinoma",slug:"transplantation-for-hepatocellular-carcinoma",signatures:"Ahmad Madkhali, Murad Aljiffry and Mazen Hassanain",authors:[{id:"160646",title:"Dr.",name:"Mazen",middleName:null,surname:"Hassanain",fullName:"Mazen Hassanain",slug:"mazen-hassanain"},{id:"160660",title:"Dr.",name:"Ahmad",middleName:null,surname:"Medkhali",fullName:"Ahmad Medkhali",slug:"ahmad-medkhali"},{id:"160663",title:"Dr.",name:"Murad",middleName:null,surname:"Aljiffry",fullName:"Murad Aljiffry",slug:"murad-aljiffry"}]},{id:"42847",title:"Secondary Liver Tumors",slug:"secondary-liver-tumors",signatures:"Hesham Abdeldayem, Amr Helmy, Hisham Gad, Essam Salah, Amr Sadek, Tarek Ibrahim, Elsayed Soliman, Khaled Abuelella, Maher Osman, Amr Aziz, Hosam Soliman, Sherif Saleh, Osama Hegazy, Hany Shoreem, Taha Yasen, Emad Salem, Mohamed Taha, Hazem Zakaria, Islam Ayoub and Ahmed Sherif",authors:[{id:"72383",title:"Prof.",name:"Hesham",middleName:null,surname:"Abdeldayem",fullName:"Hesham Abdeldayem",slug:"hesham-abdeldayem"}]},{id:"40604",title:"The Assessment and Management of Chemotherapy Associated Liver Injury",slug:"the-assessment-and-management-of-chemotherapy-associated-liver-injury",signatures:"S. M. Robinson, J. Scott, D. M. Manas and S. A. White",authors:[{id:"27150",title:"Prof.",name:"Derek",middleName:null,surname:"Manas",fullName:"Derek Manas",slug:"derek-manas"},{id:"27152",title:"Mr.",name:"Steve",middleName:null,surname:"White",fullName:"Steve White",slug:"steve-white"},{id:"154098",title:"Mr.",name:"Stuart",middleName:null,surname:"Robinson",fullName:"Stuart Robinson",slug:"stuart-robinson"},{id:"167036",title:"Dr.",name:"John",middleName:null,surname:"Scott",fullName:"John Scott",slug:"john-scott"}]},{id:"42830",title:"Liver Tumors in Infancy",slug:"liver-tumors-in-infancy",signatures:"Julio C. Wiederkehr, Izabel M. Coelho, Sylvio G. Avilla, Barbara A. Wiederkehr and Henrique A. Wiederkehr",authors:[{id:"75743",title:"Prof.",name:"Julio",middleName:"Cesar",surname:"Wiederkehr",fullName:"Julio Wiederkehr",slug:"julio-wiederkehr"},{id:"83516",title:"Ms.",name:"Barbara A.",middleName:null,surname:"Wiederkehr",fullName:"Barbara A. Wiederkehr",slug:"barbara-a.-wiederkehr"},{id:"157302",title:"Mr.",name:"Henrique A.",middleName:null,surname:"Wiederkehr",fullName:"Henrique A. Wiederkehr",slug:"henrique-a.-wiederkehr"},{id:"157304",title:"Dr.",name:"Izabel",middleName:null,surname:"Coelho",fullName:"Izabel Coelho",slug:"izabel-coelho"},{id:"157305",title:"Dr.",name:"Sylvio",middleName:null,surname:"Avilla",fullName:"Sylvio Avilla",slug:"sylvio-avilla"}]},{id:"39015",title:"Liver Tumors in Infancy and Children",slug:"liver-tumors-in-infancy-and-children",signatures:"Chunbao Guo and Mingman Zhang",authors:[{id:"76767",title:"Prof.",name:"Chunbao",middleName:null,surname:"Guo",fullName:"Chunbao Guo",slug:"chunbao-guo"}]},{id:"40558",title:"Laparoscopic Radiofrequency Ablation of Liver Tumors",slug:"laparoscopic-radiofrequency-ablation-of-liver-tumors",signatures:"Mirela Patricia Sîrb Boeti, Răzvan Grigorie and Irinel Popescu",authors:[{id:"76702",title:"Dr.",name:"Mirela Patricia",middleName:null,surname:"Sîrbu Boeți",fullName:"Mirela Patricia Sîrbu Boeți",slug:"mirela-patricia-sirbu-boeti"}]},{id:"42371",title:"Surgical Management in Portal Hypertension",slug:"surgical-management-in-portal-hypertension",signatures:"Hiroshi Yoshida, Yasuhiro Mamada, Nobuhiko Taniai, Takashi Tajiri and Eiji Uchida",authors:[{id:"149697",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Yoshida",fullName:"Hiroshi Yoshida",slug:"hiroshi-yoshida"}]},{id:"42372",title:"Vasoactive Substances and Inflammatory Factors in Progression of Liver Cirrhosis with Portal Hypertension",slug:"vasoactive-substances-and-inflammatory-factors-in-progression-of-liver-cirrhosis-with-portal-hyperte",signatures:"Hao Lu, Guoqiang Li, Ling Lu, Ye Fan, Xiaofeng Qian, Ke Wang and Feng Zhang",authors:[{id:"76797",title:"Prof.",name:"Ling",middleName:null,surname:"Lu",fullName:"Ling Lu",slug:"ling-lu"},{id:"159115",title:"Dr.",name:"Lu",middleName:null,surname:"Hao",fullName:"Lu Hao",slug:"lu-hao"}]},{id:"38729",title:"Egyptian Hepatic Veno-Occlusive Disease: Surgical Point of View",slug:"egyptian-hepatic-veno-occlusive-disease-surgical-point-of-view",signatures:"Elsayed Ibrahim Salama",authors:[{id:"154331",title:"Dr.",name:"Elsayed",middleName:"I.",surname:"Salama",fullName:"Elsayed Salama",slug:"elsayed-salama"}]},{id:"42771",title:"Progressive Familial Intrahepatic Cholestasis",slug:"progressive-familial-intrahepatic-cholestasis",signatures:"Ahmad Mohamed Sira and Mostafa Mohamed Sira",authors:[{id:"153474",title:"Dr.",name:"Ahmad",middleName:null,surname:"Sira",fullName:"Ahmad Sira",slug:"ahmad-sira"},{id:"153577",title:"Dr.",name:"Mostafa",middleName:"Mohamed",surname:"Sira",fullName:"Mostafa Sira",slug:"mostafa-sira"}]},{id:"39670",title:"Management of Hepatobiliary Trauma",slug:"management-of-hepatobiliary-trauma",signatures:"Rajan Jagad, Ashok Thorat and Wei-Chen Lee",authors:[{id:"52360",title:"Prof.",name:"Wei-Chen",middleName:null,surname:"Lee",fullName:"Wei-Chen Lee",slug:"wei-chen-lee"},{id:"157213",title:"Dr.",name:"Ashok",middleName:null,surname:"Thorat",fullName:"Ashok Thorat",slug:"ashok-thorat"},{id:"157214",title:"Dr.",name:"Rajan",middleName:null,surname:"Jagad",fullName:"Rajan Jagad",slug:"rajan-jagad"}]},{id:"42374",title:"Hepatic Trauma",slug:"hepatic-trauma",signatures:"Bilal O. Al-Jiffry and Owaid AlMalki",authors:[{id:"153686",title:"Dr.",name:"Bilal",middleName:null,surname:"Aljiffry",fullName:"Bilal Aljiffry",slug:"bilal-aljiffry"},{id:"165263",title:"Dr.",name:"Owaid",middleName:null,surname:"Almalki",fullName:"Owaid Almalki",slug:"owaid-almalki"}]}]}],publishedBooks:[{type:"book",id:"967",title:"Liver Transplantation",subtitle:"Basic Issues",isOpenForSubmission:!1,hash:"d61ca05025c7154ff4579b2d6c95d7ae",slug:"liver-transplantation-basic-issues",bookSignature:"Hesham Abdeldayem and Naglaa Allam",coverURL:"https://cdn.intechopen.com/books/images_new/967.jpg",editedByType:"Edited by",editors:[{id:"72383",title:"Prof.",name:"Hesham",surname:"Abdeldayem",slug:"hesham-abdeldayem",fullName:"Hesham Abdeldayem"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2060",title:"Liver Transplantation",subtitle:"Technical Issues and Complications",isOpenForSubmission:!1,hash:"f1a1413332fb74229afd9d4d68248cbc",slug:"liver-transplantation-technical-issues-and-complications",bookSignature:"Hesham Abdeldayem and Naglaa Allam",coverURL:"https://cdn.intechopen.com/books/images_new/2060.jpg",editedByType:"Edited by",editors:[{id:"72383",title:"Prof.",name:"Hesham",surname:"Abdeldayem",slug:"hesham-abdeldayem",fullName:"Hesham Abdeldayem"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3164",title:"Hepatic Surgery",subtitle:null,isOpenForSubmission:!1,hash:"e54bf2639e53e684ac2233e94ae53c19",slug:"hepatic-surgery",bookSignature:"Hesham Abdeldayem",coverURL:"https://cdn.intechopen.com/books/images_new/3164.jpg",editedByType:"Edited by",editors:[{id:"72383",title:"Prof.",name:"Hesham",surname:"Abdeldayem",slug:"hesham-abdeldayem",fullName:"Hesham Abdeldayem"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6502",title:"Topics in the Surgery of the Biliary Tree",subtitle:null,isOpenForSubmission:!1,hash:"6e1e8b08aab8583fc30db6351ae123d6",slug:"topics-in-the-surgery-of-the-biliary-tree",bookSignature:"Hesham Abdeldayem",coverURL:"https://cdn.intechopen.com/books/images_new/6502.jpg",editedByType:"Edited by",editors:[{id:"72383",title:"Prof.",name:"Hesham",surname:"Abdeldayem",slug:"hesham-abdeldayem",fullName:"Hesham Abdeldayem"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7528",title:"Surgical Challenges in the Management of Liver Disease",subtitle:null,isOpenForSubmission:!1,hash:"581524c01bd3dca324da84c25aa31a48",slug:"surgical-challenges-in-the-management-of-liver-disease",bookSignature:"Georgios Tsoulfas",coverURL:"https://cdn.intechopen.com/books/images_new/7528.jpg",editedByType:"Edited by",editors:[{id:"57412",title:"Prof.",name:"Georgios",surname:"Tsoulfas",slug:"georgios-tsoulfas",fullName:"Georgios Tsoulfas"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"967",title:"Liver Transplantation",subtitle:"Basic Issues",isOpenForSubmission:!1,hash:"d61ca05025c7154ff4579b2d6c95d7ae",slug:"liver-transplantation-basic-issues",bookSignature:"Hesham Abdeldayem and Naglaa Allam",coverURL:"https://cdn.intechopen.com/books/images_new/967.jpg",editedByType:"Edited by",editors:[{id:"72383",title:"Prof.",name:"Hesham",surname:"Abdeldayem",slug:"hesham-abdeldayem",fullName:"Hesham Abdeldayem"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"80618",title:"Use of Additives and Evaluation of the Quality of Broiler Meat",doi:"10.5772/intechopen.101893",slug:"use-of-additives-and-evaluation-of-the-quality-of-broiler-meat",body:'Broiler production is based on increasing meat quality, improving the characteristics of the chicken meat. Characteristics such as appearance, texture, juiciness, watery, firmness, tenderness, odor, and flavor of the meat are important for the consumer’s judgment before and after purchasing a meat product. However, quantifiable meat properties, such as water-holding capacity (WHC), shear force, drip loss, cooking loss, pH, and shelf life, are indispensable for the processing of meat products with added value. Many research was carried out as an alternative to improve the quantity, quality, and homogeneity of farm animals and their products. The use of additives can contribute to improving animal performance and meat quality parameters. One of these alternatives is the supplementation of nanoparticles, probiotics, and prebiotics in the diet of broiler chickens.
In this review, general aspects of the use of nanoparticles, probiotics, and prebiotics in poultry feed are reported.
Nanomaterials are being used in agriculture, feed, and food [1]. Some are stable at high temperature and pressure [2] and can be easily assimilated into the digestive system [3]. The action mode of the nanoparticles depends mainly on many factors, such as particle size, sizes smaller than 300 nm spread in the blood, but particles smaller than 100 nm reach tissues [4]. Thus, there is better interaction with other biologically active substances due to a larger surface area
Silver nanoparticles exhibit a strong antimicrobial effect [9]. On the other hand, the use of nano-minerals, such as nano-selenium, nano-chromium, or nano-zinc, can improve the parameters of animal production, their healthiness, and the quality of the products obtained from them, research has shown better effects in relation to the inorganic salts of these elements and chelates used on a large scale in the animal feed industry [10]. Considering this, in the livestock industry, research was conducted to improve the composition and quality of meat. Thus, the enrichment of feed with nanoparticles and their effects on meat properties were evaluated.
Selenium (Se) influences the physiological function and growth performance of animals and humans [11, 12]. Thus, it is necessary for various enzymes that are active in all cells. Dietary supplementation with selenium can increase growth performance in broilers [13, 14]. Studies show that the use of nano-selenium in supplementation improved weight gain and feed-conversion rate [15, 16], higher percentages of breast and drumstick, and a lower percentage of abdominal fat [15]. Some studies indicated that supplementation of 0.30 mg/kg of selenium improves growth performance [17, 18, 19, 20]. According to Zhou and Wang [19] supplementation of diets with 0.30 mg/kg of nano-selenium with organic sources of selenium was effective in increasing growth performance and feed-conversion rates of broilers [16, 19]. Other studies showed no effect of nano-selenium supplementation in the diet in relation to body weight gain [21] and growth performance [22].
Zinc (Zn) is essential with widely variable functions in many important enzymatic processes of glucose, protein, and lipid metabolism and production and secretion of hormones [23]. It is nutritionally essential for the development and maintenance of growth performance in broilers [24]. The permitted level of Zn for poultry diets, as recommended by the National Research Council [25], is 40 mg/kg. However, high zinc content in the diet can lead to excess zinc in the feces, which causes environmental pollution [26], affects the balance of other trace elements in the body, and can reduce the stability of vitamins and other nutrients [27]. The substitution of the inorganic source of ZnO by nano-ZnO or combined nano-ZnO and Zn promoted the growth of broilers, increased the absorption of Zn and antioxidant status without negative influence on the distribution of selected minerals in broiler tissues [28]. Other studies have shown that nano-Zn supplementation improved weight gain and feed efficiency [29, 30], decreased cholesterol levels [31], decreased abdominal lipids [30] as well as improved the meat quality of broilers [30]. A concentration of 2.5 ppm of nano-ZnO can improve the performance of broilers [32]. Concentrations of 20 and 60 mg/kg of nano-ZnO can promote body weight gain [33].
Silver (Ag) has been considered antibacterial made by humans and can be used as an additive instead of antibiotics due to its antibacterial properties and adaptability to biological systems [34]. Nanosilver was destructive in the influence on pathogenic intestinal microorganisms and induced better nutrient absorption, improvement in feed intake, weight gain, and feed efficiency of broilers [35]. However, the study conducted by Ahmadi [36] showed that when Ag-NPs were introduced in diets there was no improvement compared to control treatment, performance, body weight, feed intake, feed-conversion rate, and feed efficiency of broilers during a 42-day experimental period. This effect may be a result of Ag-NPs could affect organisms in the intestine (intestinal microflora). Nanosilver is an effective elimination agent against a broad spectrum of Gram-negative and Gram-positive bacteria [37], including antibiotic-resistant strains [38, 39].
Manganese (Mn) have an important role in bone development, normal nutrient metabolism, and biochemical processes, such as pyruvate carboxylase, superoxide dismutase, and glycolyltransferase [40, 41]. Levels of 100–400 mg/kg supplemental manganese sulfate (MnSO4) decreased abdominal fat deposition [42, 43] and the level of malondialdehyde (MDA) in the broiler muscle, reducing lipoprotein lipase activity and increasing the activity of superoxide dismutase containing Mn (MnSOD) [42]. According to Brooks et al. [44] supplementation of Mn 20–500 mg/kg in diets for broilers did not affect BWG (weight gain) or FI (feed intake). Several other studies found no effects of dietary levels of Mn on growth performance [40, 42, 45, 46, 47, 48].
Chromium (Cr) is important for physiological and nutritional activity [49]. It has potent hypocholesterolemic and antioxidant properties. It helps in the metabolism of fats, carbohydrates, and protein in animals; manifests itself in reducing the amount of glucose and cholesterol in the blood; helps in reducing fat deposits; and stimulates the formation of muscle tissue [50]. Kumari et al. [51] reported higher weight gain, the feed-conversion efficiency in the diet can produce lean meat with decreased muscle cholesterol and fat percentage for dietary supplementation with nano-Cr (400–1600 ppb). In the study conducted with chromium and nano-chromium supplementation and under thermal stress the results showed better performance, including weight gain and feed-conversion rate of broilers [52].
The pH influences the quality of meat that reflects the change in acidity in the fermentation process of muscle tissue and speed of glycogen fermentation after slaughter, the stable pH value is conducive to normal maturation of muscles [53]. After slaughter, a rapid decrease in pH in the muscle results in the denaturation of the myofibrillar protein with the decrease in protein solubility, obtaining a poor WHC and greater drip loss [54], decreased juiciness, and intense muscle coloration [55].
The increase in the pH value observed after selenium supplementation indicates a delay in the metabolic conversion of glucose into lactic acid in the postmortem muscle [18]. The breast muscles of chickens that received nano-Se supplementation showed higher pH values after 45 min of 6.17 and after 24 h pH value 5.85 [18]. Similar results were reported for chicken breast meat with a Met-Se diet [56]. Mohammadi et al. [16] used dietary sources of Se and REO (rosemary essential oil) and did not observe effect at pH 4 h after slaughter.
Studies by Liu et al. [24] showed that Zn supplementation increases the pH value (5.88–6.06) after 24 h in the thigh muscle independent of the Zn source. A similar study was conducted by El-Hack et al. [30] who observed an increase in the pH value from 5.5 to 6.0 when supplemented with nano-ZnNPs. However, pH values of 6.15–6.25 were observed in chicken meat when supplemented to diet with nano-Zn (ZONPs - 10–50 ppm zinc oxide) [57]. Already lower pH values of 5.63–5.69 for chicken meat using nano-ZnO supplementation (2.5–40 ppm) were reported by Hussan et al. [32]. Supplemental Zn significantly increased pH values in broiler muscle [24, 57]. In agreement, Selim et al. [58] reported that chickens fed ZONPs reduced the pH of the breast muscle and thigh by 6.8%. ZONPs at 40 ppm reduced color and overall acceptability compared to control. According to Selim et al. [58], the use of ZONPs at 40 or 80 ppm did not affect the sensory evaluation of chicken meat, including texture, aroma, color, and general acceptability.
Shokri et al. [48] reported higher pH values for broilers fed diets supplemented with nano-Mn when compared with control, pH values 6.41–6.44 for breast and pH values of 6.50–6.83 for thigh after slaughter. After 4 h of slaughter, pH values of 6.15–6.24 for breast meat and thigh pH values of 5.99–6.20 were observed. Lu et al. [42] reported that the added Mn content had no effect on water-retention capacity and pH values in the thigh muscles and intramuscular fat in the chest and thigh muscles.
In a study conducted by Hashemi et al. [59], there were no differences in pH values after slaughter between control poultry and poultry fed nano-Ag, pH values from 5.38 to 5.78 for breast muscle were observed.
According to Sams and Mills [60], the normal pH values at the end of the postmortem process are between 5.60–5.80 and 5.78–5.86, respectively. However, according to Soeparno [61], normal pH values would be in the range of 5.3–6.5. The high muscle pH makes the meat more susceptible to bacterial deterioration, while the low muscle pH increases the shelf life of chicken meat [62].
Some evidence indicates positive correlations between WHC and pH and a negative correlation between WHC and humidity [55]. In fact, Young et al. [63] explained that there is no good relative correlation between pH and water-retention capacity, and the lower overall final pH did not result in an overall decrease in water-retention capacity.
According to Huff-Lonergan and Lonergan [64], meat oxidation could decrease sensitivity to hydrolysis, weaken protein degradation, and reduce water reserves among myofibrils, which would increase meat juice loss by influencing softness and water-retention capacity.
Selenium is an essential trace element that positively regulates the antioxidant defense mechanism and is vital for the body’s intra- and extracellular antioxidant systems [65]. Research shows improvement in antioxidant properties [18, 19, 65]. For levels from 0.15 to 0.3 ppm using different sources of if there was an improvement in oxidation levels [20].
MDA is one of the final products of the peroxidation of polyunsaturated fatty acids in cells and is a marker of oxidative stress [66]. Concentrations of 0.3–0.5 mg/kg of nano-Se in diet supplementation were effective to improve oxidation resistance by reporting lower MDA concentration in broiler samples fed diets supplemented with nano-Zn [18, 65]. The storage under cooling of the chest and thigh muscles is supplemented with Se observed a decrease in MDA concentration [16]. In addition, El-Deep et al. [17] reported a reduction in lipid peroxidation (MDA content) in broilers under high ambient temperature.
Changes in carcass characteristics may be due to increased tissue zinc residue, the effect of zinc on the antioxidant status and the oxidative enzyme, and especially the antioxidant function and water-holding capacity of muscle [24, 33, 58]. In the study by El-Hack et al. [30] the activity of liver enzymes and malondialdehyde (MDA) decreased in the groups treated with nano-Zn (ZnNPs). Supplementation of broilers with 25 and 50 mg/kg of nano-Zn showed lower TBA values [67].
Hashemi et al. [59] observed an increase in MDA levels with an increase in nano-Ag supplementation levels. Protein oxidation can lead to the production of intermolecular bonds, including disulfide, dityrosine, and other intermolecular bridges to form the aggregation and polymerization of proteins [68].
Jankowski et al. [69] indicated that the antioxidant system worked properly when Mn was added in the form of nanoparticles, which can be attributed to the increase in the activity of Mn-SOD, GPx, and CAT. Lu et al. [70] reported that broilers fed diets supplemented with Mn presented low concentrations of MDA in the thigh muscle. Similar results were obtained when nano-Mn was added to the diets causing a reduction in the concentration of MDA in the thigh muscle in storage under refrigeration [48]. In contrast, Bozkurt et al. [71] reported that MDA concentrations increased in broilers fed diets supplemented with Mn. Already Bulbul et al. [72] reported that organic and inorganic sources of Zn and Mn decreased oxidative stress in laying hens.
According to Ognik et al. [73], a dose of 10 mg/kg in the form of NP-Mn2O3 induced large-scale lipid oxidation reactions. The reduction of Mn content, regardless of the form used, is disadvantageous, since it weakens the defense of the antioxidant system, which can induce oxidative processes in cells. In addition, the increase in dietary levels of Mn from 0 to 200 mg/kg in the diet regardless of the source showed lower values of TBARS [42, 43, 45, 70]. According to Kim et al. [43], high levels of Mn in the diet can be considered to improve carcass quality, preferably from the nano-Mn source because it presents higher bioavailability of Mn.
The oxidation of lipids in the breast muscle is a representative factor that reduces the quality of meat [74], and Mn is indicated as a necessary element for the production of SOD (superoxide dismutase) to increase antioxidant capacity and improve meat quality in chickens [41]. Oxidative changes in intramuscular lipids and products were determined based on TBARS [75, 76]. Thus, it has been demonstrated that the use of Mn in diets in organic (manganese methionine) or inorganic (MnO) forms increases MDA, glutathione peroxidase, and nitrogen oxide in chicken meat exposed to high-density stocking stress [71].
Studies report that Mn significantly reduced MDA levels in broilers [42, ] and turkeys [77]. This may be due to the change in the activity of MnSOD (superoxide dismutase) in the mitochondria of muscle cells because MnSOD plays an important role in delayed lipid peroxidation of the cell membrane. However, there is an increase in the effect of MDA concentration with high Mn in the diet in the longissimus thoracis of pigs [78].
The activity of GSH-Px (glutathione peroxidase) affecting the oxidation state of myofibrillar protein could affect drip loss [79]. Studies report lower drip losses in breast meat of chickens who were fed nano-Se [19, 65] and organic Se [21, 80].
The pH drop retard leads to reduced protein denaturation, and consequently, to reduced drip and cooking loss [81], thus improving the water-retention capacity of meat. The use of nano-Se showed a decrease in drip loss [18].
Chicken meat with low pH has been associated with low WHC, which results in loss of cooking and drip loss. The lower pH decreases the ability of muscle proteins to bind to water, causing the shrinkage of myofibrils [82].
Some studies with nano-Se supplementation have observed an increase in meat water-retention capacity [83, 84]. In contrast, Mohammadi et al. [16] in the study reported that using dietary sources of Se and REO (rosemary essential oil) had no effect on water retention capacity (WHC) in the thigh and breast muscles in broiler.
Meat color and drip loss are important indices for assessing meat quality and are closely related to the oxidation state in muscles. The color of the meat is determined by the oxidation state of myoglobin [24]. The use of supplementation with if improves antioxidant capacity and thus could increase the content of myoglobin, thus improving the color of meat [83, 85]. In addition, when phospholipids in cell membranes are oxidized, changes in cellular permeability occur, leading to decreased water-retention capacity of the muscle.
Drip loss is commonly used as an indicator of the water-retention capacity (WHC) of meat. The lower drip loss reflected the higher content of water-soluble nutrients and the increase in meat juiciness [86]. Lower drip losses of the breast muscle were observed when supplemented with nano-Zn (ZONPs 25–50 mg/kg ZnO) [57]. On the other hand, Liu et al. [24] and Selim et al. [58] reported that additional nano ZONPs decreased drip loss in broilers. Similarly, Saenmahayak et al. [87] reported that drip loss increased significantly in the muscles of broilers fed zinc supplemented diets.
The decrease in drip loss in the breast muscle [78] can be attributed to a stable pH value [88].
Regarding water-retention capacity (WHC) no difference was observed in supplementation with nano-Zn [32, 87]. In contrast to our results, Yang et al. [89] recorded an increase in breast muscle WHC with the addition of inorganic zinc in broilers.
The physical and chemical properties of proteins, including solubility, hydrophobicity, WHC, and even nutritional value can be modified by protein oxidation [90]. In postmortem muscle, protein oxidation has been gradually recognized as an important factor for meat quality. During postmortem storage, the muscle has a decreased ability to maintain its antioxidant defense system, and this can cause an increased accumulation of reactive oxygen and nitrogen species [91]. Improved antioxidant status can promote the maintenance of cell membrane integrity [65], which can be explained by the results of water-retention capacity. According to Hashemi et al. [59], there was no significant difference for breast in WHC value, while thigh supplementation with nano-Ag resulted in higher levels of WHC, which may be due to the low level of protein oxidation.
The quantifiable properties of meat are indispensable for processors involved in the manufacture of meat products, such as water-retention capacity (WHC), shear force, drip loss, cooking loss, pH, shelf life, protein solubility, and fat-binding capacity [92].
Muscle pH had a significant positive correlation with water-retention capacity (WHC), and WHC had a significant correlation with an a* value [55].
In addition, thighs with nano ZnNPs lower loss by cooking [67].
The color of meat is an indicator of quality, which represents its freshness for consumers [93]. Some studies did not report differences in the color of the breast muscles for supplementation with nano-Se compared to the control [18, 56, 83]. Meanwhile, Boiago et al. [94] observed a decrease in L* values of breast muscles for broilers fed diets supplemented with Met-Se Se, which may be related to a reduction in moisture on the meat surface because of increased water-retention capacity [95].
El-Hack et al. [30] reported lower L* values for breast meat from chickens treated with dietary supplements of nano-Zn ZnNPs and did not observe differences for a* values. For thigh meat, the different treatment groups with nano ZnNPs did not affect the values of L* and a* [67]. However, for the value of b* there was an increase for the thigh muscle [24, 67] and the breast muscle [24, 30, 89].
According to Hashemi et al. [59] in the treatments of zeolite, nano-silver (50 and 75 ppm) there was no significant difference for the color parameters parameter L*, a*, and b* in the breast muscle.
Lipid oxidation can promote the accumulation of metmyoglobin, such as brown pigments, in meat [94, 96]. The increase in the yellowing of meat may be due to the increase in the formation of oxymyoglobin [97]. In addition, lipid oxidation is associated with the destruction of meat pigments, such as carotenoids [98]. Some researchers have also demonstrated that there is a significant negative correlation between the color values of clarity of breast meat and the pH of breast meat [62]. Color is the most important characteristic for the appearance of meat [99], which is influenced by sex, genotype, and breed; moreover, it relates to the pH value [100].
Softness, described as shear force, is an important indicator of consumer acceptability and is determined by the structural properties of various proteins and fats in muscle [101]. Nano-Se supplementation showed a decrease in the value of the shear force of the breast muscles and lower cooking loss [18].
Baowei et al. [85] reported that SS supplementation in the 0.3 g/kg diet reduced the hardness of the goose’s breast muscles. Results indicate that the supplementation of broiler feed with organic Se or nano-Se leads to improvement of meat quality, in relation to the addition of inorganic Se [102].
Many studies have shown that IMP (inosine 5′-monophosphate) contributes to the sensory perception of meat [101]. A higher IMP content was observed in chickens supplemented with nano-Se may be associated with a better quality of Guangxi Yellow chicken meat [19].
Zn supplementation increased the content of intramuscular breast muscle fat in broilers independent of the source of Zn [24]. Hodgson et al. [103] observed that higher levels of intramuscular fat caused a significant decrease in shear force. Liu et al. [24] showed that Zn supplementation decreased the shear force of the thigh muscle and breast muscles, regardless of the source of Zn.
Texture parameters such as succulence, softness, and flavor obtained lower values when using a diet with nano ZnNPs [30].
Regarding the texture profile of broiler breast meat for hardness, cohesiveness, gumminess, and chewiness were influenced by the treatment with nano Ag (NZ75 higher values), while adhesiveness and springiness were not influenced [59]. For the thigh muscle texture profile of broilers, hardness, adhesiveness, and cohesiveness were not influenced, however there was a difference in springiness for supplementation with nano Ag [59]. Results may be related to water-retention capacity (WHC), a quality parameter related to the meat softness process, which is an important parameter in the sensory evaluation of meat [104].
Yang et al. [77] reported the use of Mn in the duck diet, they observed a significant increase in intramuscular fat and decreased shear strength, showing similar results in studies conducted by Yang et al. [89] in broilers.
Meat softness is a factor used to evaluate the acceptability of the consumer of cooked meat [99] and is generally associated with the content of MIF and muscle fiber structure [105]. Shear force is a reliable indicator that inversely represents the softness of the meat.
Probiotics are considered live microbial supplements that beneficially influence the host by improving intestinal microbial balance [106], stimulating metabolism, reducing the risk of infection by opportunistic pathogens [107], tend to improve levels of body antioxidants, which can improve the health of broilers [108]. The study has shown that dietary probiotic supplementation increases growth rate, feed efficiency, and immunity in chickens [109], improve chicken meat quality, such as WHC, tenderness, and oxidative stability [110], increase weight gain and feed-conversion ratio, improve antioxidant capacity in organs and muscle tissue in heat-stressed chickens [111]. Probiotics used in animal nutrition include groups of bacteria, yeasts, and fungi, such as
The prebiotic is a nondigestible feed ingredient that, through its metabolization by microorganisms in the gut, modulates the composition and/or activity of the gut microbiota, thus conferring a beneficial physiological effect on the host [115]. The prebiotics are used as substrates for survival and multiplication of probiotics in a lower gut region that act as symbiotics [116]. Some prebiotics are composed of diverse sugar units. Therefore, each prebiotic may influence the animals differently [117]. Prebiotics such as fructooligosaccharides (FOS), galactooligosaccharides (GOS), and mannan oligosaccharides (MOS) are considered preventive agents, as they can select a gastrointestinal microbiota that not only benefits the host but can serve as a barrier to the colonization of pathogens [118]. Besides, feed additives, such as probiotics, prebiotics, and symbiotics have been proposed as a nutritional strategy to improve the resilience of animals against heat stress [119].
Probiotics have a beneficial effect on the host animal, improving its intestinal microbial balance [120]. This creates a healthy intestinal environment with increasing counts of healthy bacteria and suppresses intestinal pathogens, thereby improving digestion and nutrient utilization [121]. According to Al-Shawi et al. [122], the animal not only requires an optimal amount of food but also must improve the digestibility of the food to maximize growth. Some studies have reported lower feed intake in broilers fed with probiotics [123, 124, 125, 126]. Thus, increased nutrient absorption in broilers produces lower feed intake to maintain their nutrition needs [127]. Amerah et al. [123] reported that the inclusion of
The inclusion of
Bai et al. [133] evaluated the feeding of broilers with
According to Patel et al. [141], the effectiveness of probiotics is influenced by the selection of the most efficient strains, manipulation of genes, combination of several strains and the combination of probiotics, and synergistically by the action of the components. However, the use of multiple strains may improve the effectiveness of probiotics as they beneficially affect the host by enhancing growth-promoting bacteria with competitive antagonism against pathogenic bacteria in the gastrointestinal tract [142].
In the broilers fed with multi-strain probiotics, such as
Therefore, the effectiveness of the application of probiotics varies depending on several factors, such as probiotic strains, dosage of administration, method of administration, diet composition, age and breed of birds, and management conditions [114, 131, 132, 136, 144].
The positive prebiotic effect on growth performance can be due to the ability of prebiotics to enhance lactobacilli and bifidobacteria populations, and these beneficial bacteria compete with harmful bacteria for colonization [145].
Prebiotic diet reported higher carcass weight, carcass yield, and breast muscle weight [146, 147], and an increase in body weight gain [148].
The study observed a significant effect of diet on feed conversion, and control birds showed poor feed conversion. The rearing system also affected weight gain and feed intake, so confined birds had better weight gain and feed intake [149]. Birds fed diets supplemented with probiotics and prebiotics showed greater body weight and weight gain, whereas feed intake was greater in control birds. Similar studies, diets with prebiotic treatment and probiotic alone, reported better responses for body weight gain and FCR compared to the use of symbiotic treatment [150]. Several other studies also showed that the addition of probiotics or prebiotics alone or in combinations as synbiotics in feeds had no effect on the feed intake of broiler chickens [151]. On the other hand, dietary synbiotic supplementation can increase the breast muscle weight of broilers in comparison with those fed the basal diet [152].
The physicochemical properties of meat are important and can determine its storage or further processing. They are interconnected and influence the sensory quality of meat. Thus, the use of probiotics can influence these parameters [153]. Meat quality is also a very important parameter for the effect of dietary treatment in broiler studies. The supplementation of probiotics in basal diets had beneficial effects on quality broiler meat [128, 133].
The decreased pH relates to the generation of lactic acid through the anaerobic pathway, and probably promotes the denaturation of myofibrillar proteins, and reduces the ability of these proteins to maintain water [154]. Wang et al. [155] observed the decline in pH, however, pH24h (6.01) was increased by
On the other hand, Cramer et al. [160] observed that
In cooking loss in broiler no difference was reported, regardless of probiotic feeding levels [165, 168, 169]. Also, the drip, cooking, and thaw losses on breast muscle were not observed by Benamirouche et al. [157]. However, some studies observed that heat stress increases drip and cooking loss [79, 144] of the breast meat [167]. In contrast, lower cooking loss was observed in
Meat tenderness can be estimated by measuring the shear force; lower shear force indicates tenderer meat and was one of the crucial sensory qualities that influenced the consumer [172]. The shear force in breast and drumstick meats decreased with
No interactions between probiotic feeding levels and display storage time on CIE L* (lightness), CIE a* (redness) breast muscles from chickens exposed to cyclic heat challenge were found, except for CIE b* (yellowness) [160, 161]. The quail meat color a*, b*, and L* values were decreased by probiotics treatment with all levels studied as compared to the control group [143]. Haščík et al. [178] observed an increase in a* and b* values of the thigh and an increase in the L* values of breast and thigh cuts in birds fed probiotics alone or in combination with pollen. In contrast, Haščík et al. [179] reported that a* values in breast muscle were increased, whereas the values of L* and b* for broiler breast meat were not altered because of
The MDA concentration shows the intensity of the lipid peroxidation rate in the body and indirectly shows the degree of damage by tissue peroxidation [155]. Some studies have reported an antioxidant effect of probiotic feeding on lipid oxidation, suggesting that the improved meat quality might be closely connected with its enhanced antioxidant capacity by yeast supplementation in broilers [110, 133, 135, 155, 156, 160, 169, 170, 180]. Thus, it can improve the quality parameters of broiler meat under heat stress. However, in a study by Kim et al. [161] no effects on lipid oxidation stability were observed.
Sensory evaluation test results for lightly cooked breast meat, there was an improvement in the odor of chicken meat fed with
Broiler chickens subjected to heat stress can induce a lower final pH with variation in meat color, water-holding capacity (WHC), and meat tenderness [81, 144, 163], resulting in lower acceptability of the meat by the consumer. In this sense, poultry farming strives to mitigate the negative effects of heat stress on poultry production, to reduce economic losses. The main concerns about the use of these bioactives are their efficient administration under fully controlled conditions.
Heat stress not only impairs muscle growth and structure [160, 183], but also influences meat quality, decreasing the pH value, water-retention capacity and redness, and increasing skeletal muscle lightness in chickens [5, 184, 185, 186].
Some studies suggest that the glucose level in skeletal muscles may be influenced by heat stress, causing an accumulation of lactic acid in muscle tissue [144], and a rapid decline in pH with low pH values final [5, 144, 160]. Tavaniello et al. [147] and Maiorano et al. [187] no reported influenced pH 24 (5.76 and 5.87) fully fit within the pH range accepted for commercial poultry meat [178, 179]. Already lower values of pH 24 h postmortem were observed under heat stress conditions with and without the use of symbiotic compared to the control.
The redness a∗ value was reduced in breast meat from prebiotics treatment compared to control [147]. Yet, L∗ and b∗ values were similar between the experimental groups. Dietary symbiotic addition reduced L* value. However, it did not affect the b* value [152]. The a* values were lower for the thermoneutral symbiotic, but higher a* values were reported for heat stress and symbiotic. Other studies reported that heat stress can increase L* and reduce a* and b* of breast meat [119]. This could be due to the denaturation of sarcoplasmic proteins, which results in the scattering of light [144].
Less drip and cooking losses were observed, and there was no effect on breast muscle shear force in broilers fed symbiotic compared to those fed a basal diet [152]. However, sob heat stress increased drip loss and cooking loss and decreased shear force in broilers when compared with those under thermoneutral temperature [152]. Similar results were found in broiler exposed to heat stress, which observed decrease in the WHC [119].
Broilers exposed to heat stress reported higher MDA concentration but lower activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the breast muscle. Compared with broilers fed the basal diet, symbiotic supplementation decreased MDA content and increased GSH-Px activity of breast muscle in broilers [152].
Meat quality is influenced by several factors, such as food. The use of additives to improve meat characteristics was evaluated. It was shown that the type of additive, the quantity, and the method of application are important parameters for obtaining chicken meat with desirable characteristics for the consumer and for the industry in obtaining meat-derived products.
The authors declare no conflict of interest.
IntechOpen implements a robust policy to minimize and deal with instances of fraud or misconduct. As part of our general commitment to transparency and openness, and in order to maintain high scientific standards, we have a well-defined editorial policy regarding Retractions and Corrections.
",metaTitle:"Retraction and Correction Policy",metaDescription:"Retraction and Correction Policy",metaKeywords:null,canonicalURL:"/page/retraction-and-correction-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"IntechOpen’s Retraction and Correction Policy has been developed in accordance with the Committee on Publication Ethics (COPE) publication guidelines relating to scientific misconduct and research ethics:
\\n\\n1. RETRACTIONS
\\n\\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\\n\\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\\n\\nPublishing of a Retraction Notice will adhere to the following guidelines:
\\n\\n1.2. REMOVALS AND CANCELLATIONS
\\n\\n2. STATEMENTS OF CONCERN
\\n\\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\\n\\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\\n\\n3. CORRECTIONS
\\n\\nA Correction will be issued by the Academic Editor when:
\\n\\n3.1. ERRATUM
\\n\\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\\n\\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\\n\\n3.2. CORRIGENDUM
\\n\\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\\n\\n4. FINAL REMARKS
\\n\\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\\n\\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\\n\\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\\n\\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
\\n\\nPolicy last updated: 2017-09-11
\\n"}]'},components:[{type:"htmlEditorComponent",content:'IntechOpen’s Retraction and Correction Policy has been developed in accordance with the Committee on Publication Ethics (COPE) publication guidelines relating to scientific misconduct and research ethics:
\n\n1. RETRACTIONS
\n\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\n\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\n\nPublishing of a Retraction Notice will adhere to the following guidelines:
\n\n1.2. REMOVALS AND CANCELLATIONS
\n\n2. STATEMENTS OF CONCERN
\n\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\n\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\n\n3. CORRECTIONS
\n\nA Correction will be issued by the Academic Editor when:
\n\n3.1. ERRATUM
\n\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\n\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n3.2. CORRIGENDUM
\n\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n4. FINAL REMARKS
\n\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\n\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\n\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\n\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
\n\nPolicy last updated: 2017-09-11
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6675},{group:"region",caption:"Middle and South America",value:2,count:5955},{group:"region",caption:"Africa",value:3,count:2459},{group:"region",caption:"Asia",value:4,count:12718},{group:"region",caption:"Australia and Oceania",value:5,count:1017},{group:"region",caption:"Europe",value:6,count:17720}],offset:12,limit:12,total:134177},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"1",sort:"dateEndThirdStepPublish"},books:[{type:"book",id:"11254",title:"Optical Coherence Tomography",subtitle:null,isOpenForSubmission:!0,hash:"a958c09ceaab1fc44c1dd0a817f48c92",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11254.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11616",title:"Foraging",subtitle:null,isOpenForSubmission:!0,hash:"955b60bb658c8d1a09dd4efc9bf6674b",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11616.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11632",title:"Updated Research on Bacteriophages",subtitle:null,isOpenForSubmission:!0,hash:"d34dfa0d5d10511184f97ddaeef9936b",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11632.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11697",title:"Scoliosis",subtitle:null,isOpenForSubmission:!0,hash:"fa052443744b8f6ba5a87091e373bafe",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11697.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11699",title:"Neonatal Surgery",subtitle:null,isOpenForSubmission:!0,hash:"e52adaee8e54f51c2ba4972daeb410f7",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11699.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11730",title:"Midwifery",subtitle:null,isOpenForSubmission:!0,hash:"95389fcd878d0e929234c441744ba398",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11730.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11858",title:"Terahertz Radiation",subtitle:null,isOpenForSubmission:!0,hash:"f08ee0bf20cd8b5fa772b4752081f2fe",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11858.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11773",title:"Archaeology - Challenges and Updates",subtitle:null,isOpenForSubmission:!0,hash:"17d91462fa926279f65164ac0d5641cd",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11773.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11776",title:"Fashion Industry",subtitle:null,isOpenForSubmission:!0,hash:"e8d53d1029a7bccf825aa55d43fecc68",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11776.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11794",title:"Coconut Cultivation",subtitle:null,isOpenForSubmission:!0,hash:"48e1cb42a4162f64cae3a2e777472f21",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11794.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11797",title:"Clostridium difficile",subtitle:null,isOpenForSubmission:!0,hash:"4cb066b44bb8d4a8b93a627de26e3ebf",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11797.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11809",title:"Lagomorpha",subtitle:null,isOpenForSubmission:!0,hash:"1e8fd5779205c16e5797b05455dc5be0",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11809.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:30},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:7},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:14},{group:"topic",caption:"Computer and Information Science",value:9,count:8},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:10},{group:"topic",caption:"Engineering",value:11,count:24},{group:"topic",caption:"Environmental Sciences",value:12,count:5},{group:"topic",caption:"Immunology and Microbiology",value:13,count:7},{group:"topic",caption:"Materials Science",value:14,count:9},{group:"topic",caption:"Mathematics",value:15,count:5},{group:"topic",caption:"Medicine",value:16,count:83},{group:"topic",caption:"Neuroscience",value:18,count:5},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:6},{group:"topic",caption:"Physics",value:20,count:1},{group:"topic",caption:"Psychology",value:21,count:4},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:24},{group:"topic",caption:"Technology",value:24,count:1}],offset:12,limit:12,total:249},popularBooks:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4431},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1677,editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1337,editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1309,editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:847,editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",publishedDate:"June 15th 2022",numberOfDownloads:2273,editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:591,editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:515,editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:413,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",publishedDate:"June 8th 2022",numberOfDownloads:2194,editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:341,editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"11043",title:"Endometriosis",subtitle:"Recent Advances, New Perspectives and Treatments",isOpenForSubmission:!1,hash:"7baf1c70b11d41400bb9302ae9411ca4",slug:"endometriosis-recent-advances-new-perspectives-and-treatments",bookSignature:"Giovana Ap. Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/11043.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"185930",title:"Associate Prof.",name:"Giovana",middleName:null,surname:"Gonçalves",slug:"giovana-goncalves",fullName:"Giovana Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10536",title:"Campylobacter",subtitle:null,isOpenForSubmission:!1,hash:"c4b132b741dd0a2ed539b824ab63965f",slug:"campylobacter",bookSignature:"Guillermo Tellez-Isaias and Saeed El-Ashram",coverURL:"https://cdn.intechopen.com/books/images_new/10536.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"73465",title:"Dr.",name:"Guillermo",middleName:null,surname:"Téllez",slug:"guillermo-tellez",fullName:"Guillermo Téllez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",isOpenForSubmission:!1,hash:"f197f6062c1574a9a90e50a369271bcf",slug:"starch-evolution-and-recent-advances",bookSignature:"Martins Ochubiojo Emeje",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11083",title:"Hazardous Waste Management",subtitle:null,isOpenForSubmission:!1,hash:"d553bd4f6f1c4b115ca69bd19faac7dc",slug:"hazardous-waste-management",bookSignature:"Rajesh Banu Jeyakumar, Kavitha Sankarapandian and Yukesh Kannah Ravi",coverURL:"https://cdn.intechopen.com/books/images_new/11083.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"218539",title:"Dr.",name:"Rajesh Banu",middleName:null,surname:"Jeyakumar",slug:"rajesh-banu-jeyakumar",fullName:"Rajesh Banu Jeyakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10848",title:"Tribology of Machine Elements",subtitle:"Fundamentals and Applications",isOpenForSubmission:!1,hash:"3c4ca4c4692ca8d4fa749b4ae81ec1fa",slug:"tribology-of-machine-elements-fundamentals-and-applications",bookSignature:"Giuseppe Pintaude, Tiago Cousseau and Anna Rudawska",coverURL:"https://cdn.intechopen.com/books/images_new/10848.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"18347",title:"Prof.",name:"Giuseppe",middleName:null,surname:"Pintaude",slug:"giuseppe-pintaude",fullName:"Giuseppe Pintaude"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10856",title:"Crude Oil",subtitle:"New Technologies and Recent Approaches",isOpenForSubmission:!1,hash:"8d0a7ca35b3de95b295dc4eab39a087e",slug:"crude-oil-new-technologies-and-recent-approaches",bookSignature:"Manar Elsayed Abdel-Raouf and Mohamed Hasan El-Keshawy",coverURL:"https://cdn.intechopen.com/books/images_new/10856.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"102626",title:"Prof.",name:"Manar",middleName:null,surname:"Elsayed Abdel-Raouf",slug:"manar-elsayed-abdel-raouf",fullName:"Manar Elsayed Abdel-Raouf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9625",title:"Spinocerebellar Ataxia",subtitle:"Concepts, Particularities and Generalities",isOpenForSubmission:!1,hash:"365a7025fd46eb45de2549bdd9d50b98",slug:"spinocerebellar-ataxia-concepts-particularities-and-generalities",bookSignature:"Patricia Bozzetto Ambrosi",coverURL:"https://cdn.intechopen.com/books/images_new/9625.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"221787",title:"Dr.",name:"Patricia",middleName:null,surname:"Bozzetto Ambrosi",slug:"patricia-bozzetto-ambrosi",fullName:"Patricia Bozzetto Ambrosi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10905",title:"Plant Defense Mechanisms",subtitle:null,isOpenForSubmission:!1,hash:"84ad5b27dde5f01dc76087d0fd6fa834",slug:"plant-defense-mechanisms",bookSignature:"Josphert Ngui Kimatu",coverURL:"https://cdn.intechopen.com/books/images_new/10905.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"224171",title:"Prof.",name:"Josphert N.",middleName:null,surname:"Kimatu",slug:"josphert-n.-kimatu",fullName:"Josphert N. Kimatu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10686",title:"Natural Gas",subtitle:"New Perspectives and Future Developments",isOpenForSubmission:!1,hash:"581763788a6a59e653a9d1d9b5a42d79",slug:"natural-gas-new-perspectives-and-future-developments",bookSignature:"Maryam Takht Ravanchi",coverURL:"https://cdn.intechopen.com/books/images_new/10686.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"2416",title:"Dr.",name:"Maryam",middleName:null,surname:"Takht Ravanchi",slug:"maryam-takht-ravanchi",fullName:"Maryam Takht Ravanchi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10988",title:"Railway Transport Planning and Manageme",subtitle:null,isOpenForSubmission:!1,hash:"5cb54cc53caedad9ec78372563c82e2c",slug:"railway-transport-planning-and-management",bookSignature:"Stefano de Luca, Roberta Di Pace and Chiara Fiori",coverURL:"https://cdn.intechopen.com/books/images_new/10988.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"271061",title:"Prof.",name:"Stefano",middleName:null,surname:"de Luca",slug:"stefano-de-luca",fullName:"Stefano de Luca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"149",title:"Immunochemistry",slug:"immunochemistry",parent:{id:"13",title:"Immunology and Microbiology",slug:"immunology-and-microbiology"},numberOfBooks:2,numberOfSeries:0,numberOfAuthorsAndEditors:42,numberOfWosCitations:54,numberOfCrossrefCitations:17,numberOfDimensionsCitations:50,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"149",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"7013",title:"Immunohistochemistry",subtitle:"The Ageless Biotechnology",isOpenForSubmission:!1,hash:"cd11a72871d4b30ec4855a33d49adf3f",slug:"immunohistochemistry-the-ageless-biotechnology",bookSignature:"Charles F. Streckfus",coverURL:"https://cdn.intechopen.com/books/images_new/7013.jpg",editedByType:"Edited by",editors:[{id:"29033",title:"Prof.",name:"Charles",middleName:"F.",surname:"Streckfus",slug:"charles-streckfus",fullName:"Charles Streckfus"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2295",title:"Trends in Immunolabelled and Related Techniques",subtitle:null,isOpenForSubmission:!1,hash:"995b8354458c26a34858374c0e59d003",slug:"trends-in-immunolabelled-and-related-techniques",bookSignature:"Eltayb Abuelzein",coverURL:"https://cdn.intechopen.com/books/images_new/2295.jpg",editedByType:"Edited by",editors:[{id:"120202",title:"Dr.",name:"Eltayb",middleName:null,surname:"Abuelzein",slug:"eltayb-abuelzein",fullName:"Eltayb Abuelzein"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:2,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"36210",doi:"10.5772/35692",title:"Immunological Methods for the Detection of Campylobacter spp. - Current Applications and Potential Use in Biosensors",slug:"immunological-methods-for-the-rapid-detection-of-campylobacter-spp-current-applications-and-potent",totalDownloads:3439,totalCrossrefCites:0,totalDimensionsCites:12,abstract:null,book:{id:"2295",slug:"trends-in-immunolabelled-and-related-techniques",title:"Trends in Immunolabelled and Related Techniques",fullTitle:"Trends in Immunolabelled and Related Techniques"},signatures:"Omar A. Oyarzabal and Cynthia Battie",authors:[{id:"105485",title:"Prof.",name:"Omar",middleName:null,surname:"Oyarzabal",slug:"omar-oyarzabal",fullName:"Omar Oyarzabal"},{id:"106668",title:"Prof.",name:"Cynthia",middleName:null,surname:"Battie",slug:"cynthia-battie",fullName:"Cynthia Battie"}]},{id:"36202",doi:"10.5772/36688",title:"Recent Progress in Noncompetitive Hapten Immunoassays: A Review",slug:"noncompetitive-immunoassay-to-hapten-molecules",totalDownloads:1769,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"2295",slug:"trends-in-immunolabelled-and-related-techniques",title:"Trends in Immunolabelled and Related Techniques",fullTitle:"Trends in Immunolabelled and Related Techniques"},signatures:"Mingtao Fan and Jiang He",authors:[{id:"15909",title:"Dr.",name:"Jiang",middleName:null,surname:"He",slug:"jiang-he",fullName:"Jiang He"},{id:"109372",title:"Prof.",name:"Mingtao",middleName:null,surname:"Fan",slug:"mingtao-fan",fullName:"Mingtao Fan"}]},{id:"66392",doi:"10.5772/intechopen.85055",title:"Low-Specificity and High-Sensitivity Immunostaining for Demonstrating Pathogens in Formalin-Fixed, Paraffin-Embedded Sections",slug:"low-specificity-and-high-sensitivity-immunostaining-for-demonstrating-pathogens-in-formalin-fixed-pa",totalDownloads:1267,totalCrossrefCites:5,totalDimensionsCites:5,abstract:"The present review describes a part of the author’s own experience in applying immunoperoxidase staining to routine histopathological diagnosis. The target disorder was focused on infection. In the practice of pathology diagnosis services, it is important for us diagnostic pathologists to judge whether the lesion is caused by an infection or not. When an infectious disease is highly likely, the visualization of pathogens within the inflammatory lesion is required to suggest a causative agent. Two main approaches the author would like to introduce include (1) the use of commercially available antisera showing wide cross-reactivity to a variety of bacteria and (2) the use of diluted patients’ sera. These immunohistochemical studies employing “low-specificity” and “high-sensitivity” probes are useful for confirming the localization of pathogen within the infectious lesion.",book:{id:"7013",slug:"immunohistochemistry-the-ageless-biotechnology",title:"Immunohistochemistry",fullTitle:"Immunohistochemistry - The Ageless Biotechnology"},signatures:"Yutaka Tsutsumi",authors:[{id:"280338",title:"Dr.",name:"Yutaka",middleName:null,surname:"Tsutsumi",slug:"yutaka-tsutsumi",fullName:"Yutaka Tsutsumi"}]},{id:"36206",doi:"10.5772/37193",title:"Ferret TNF-α and IFN-γ Immunoassays",slug:"ferret-tnf-alpha-and-ifn-gamma-immunoassays",totalDownloads:1971,totalCrossrefCites:0,totalDimensionsCites:5,abstract:null,book:{id:"2295",slug:"trends-in-immunolabelled-and-related-techniques",title:"Trends in Immunolabelled and Related Techniques",fullTitle:"Trends in Immunolabelled and Related Techniques"},signatures:"Alyson Ann Kelvin, David Banner, Ali Danesh, Charit Seneviratne, Atsuo Ochi and David Joseph Kelvin",authors:[{id:"111714",title:"Dr.",name:"David",middleName:null,surname:"Kelvin",slug:"david-kelvin",fullName:"David Kelvin"},{id:"111731",title:"Dr.",name:"Alyson",middleName:null,surname:"Kelvin",slug:"alyson-kelvin",fullName:"Alyson Kelvin"},{id:"111732",title:"MSc.",name:"David",middleName:null,surname:"Banner",slug:"david-banner",fullName:"David Banner"}]},{id:"36200",doi:"10.5772/35160",title:"Evaluation of an Immuno-Chromatographic Detection System for Shiga Toxins and the E. coli O157 Antigen",slug:"evaluation-of-an-immuno-chromatographic-detection-system-for-shiga-toxins-and-e-coli-o157-antigen",totalDownloads:2187,totalCrossrefCites:2,totalDimensionsCites:4,abstract:null,book:{id:"2295",slug:"trends-in-immunolabelled-and-related-techniques",title:"Trends in Immunolabelled and Related Techniques",fullTitle:"Trends in Immunolabelled and Related Techniques"},signatures:"Ylanna Burgos and Lothar Beutin",authors:[{id:"103223",title:"Dr.",name:"Lothar",middleName:null,surname:"Beutin",slug:"lothar-beutin",fullName:"Lothar Beutin"},{id:"103567",title:"Dr.",name:"Ylanna",middleName:"Kelner",surname:"Burgos",slug:"ylanna-burgos",fullName:"Ylanna Burgos"}]}],mostDownloadedChaptersLast30Days:[{id:"63122",title:"Immune Cell Profiling in Cancer Using Multiplex Immunofluorescence and Digital Analysis Approaches",slug:"immune-cell-profiling-in-cancer-using-multiplex-immunofluorescence-and-digital-analysis-approaches",totalDownloads:1643,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"During the last years, multiplex immunofluorescence (mIF) has emerged as a very powerful tool in multiple epitope detection to study tumor tissues. This revolutionary technology is providing an important visual technique for tumor examination in formalin-fixed paraffin-embedded specimens for a better understanding of tumor microenvironment, new treatment discoveries, cancer prevention, as well as translational studies. The aim of this chapter is to highlight the use of tyramide signal amplification methodology in mIF and image analysis to identify several proteins at the same time in one single tissue and their spatial distribution in different tumor specimens including whole sections, core needle biopsies, and tissue microarrays. This type of methodology associated with image analysis can perform high-quality throughput assay in translational research studies to be applied in cancer prevention and treatments.",book:{id:"7013",slug:"immunohistochemistry-the-ageless-biotechnology",title:"Immunohistochemistry",fullTitle:"Immunohistochemistry - The Ageless Biotechnology"},signatures:"Edwin Roger Parra",authors:null},{id:"64808",title:"Detection Systems in Immunohistochemistry",slug:"detection-systems-in-immunohistochemistry",totalDownloads:2033,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Immunohistochemistry (IHC) is a process of selectively imaging antigens in cells or tissue sections by exploiting antibody specificity. This technique is widely used in diagnostic pathology and research experiments for tracking specific molecular markers characteristic of a particular cell type or cellular events such as cancerous cell development, cell proliferation, or apoptosis. Visualizing the target antigen following an antibody-antigen interaction is accomplished by different detection systems. In the simplest instance, primary antibody directly conjugated to an enzyme is responsible for both specifically binding to the antigen and catalyzing a color-producing reaction. Alternatively, complex detection systems could be designed to profoundly improve minimal detection level of the antigen. During the past years, there has been a considerable improvement in designing and introduction of new and highly sensitive detection systems. The choice of an IHC detection system is a compromise of a variety of variables including desired sensitivity, cost, and the time needed for an IHC staining to be performed. This chapter covers the immunohistochemistry detection systems with emphasis on their principle, history, advantages, and limitations and delineates factors needed to be considered for choosing an appropriate detection system for IHC applications.",book:{id:"7013",slug:"immunohistochemistry-the-ageless-biotechnology",title:"Immunohistochemistry",fullTitle:"Immunohistochemistry - The Ageless Biotechnology"},signatures:"Sorour Shojaeian, Nasim Maslehat Lay and Amir-Hassan Zarnani",authors:null},{id:"65712",title:"In Situ Identification of Ectoenzymes Involved in the Hydrolysis of Extracellular Nucleotides",slug:"in-situ-identification-of-ectoenzymes-involved-in-the-hydrolysis-of-extracellular-nucleotides",totalDownloads:922,totalCrossrefCites:0,totalDimensionsCites:2,abstract:"Adenosine triphosphate (ATP) and other nucleotides and nucleosides, such as adenosine, are signaling molecules involved in many physiological and pathophysiological processes. The group of cell and tissue responses mediated by these molecules is known as purinergic signaling. Ecto-nucleotidases are ectoenzymes expressed at the cell membrane that act sequentially to efficiently hydrolyze extracellular ATP into adenosine, and they are key elements of this signaling. There is growing interest in studying these enzymes in relation to various pathologies, especially those with an inflammatory component such as cancer. This review summarizes the main protocols for the study of the expression and in situ activity of ectoenzymes in tissue slices and cultured cells.",book:{id:"7013",slug:"immunohistochemistry-the-ageless-biotechnology",title:"Immunohistochemistry",fullTitle:"Immunohistochemistry - The Ageless Biotechnology"},signatures:"Mireia Martín-Satué, Aitor Rodríguez-Martínez and Carla Trapero",authors:null},{id:"66392",title:"Low-Specificity and High-Sensitivity Immunostaining for Demonstrating Pathogens in Formalin-Fixed, Paraffin-Embedded Sections",slug:"low-specificity-and-high-sensitivity-immunostaining-for-demonstrating-pathogens-in-formalin-fixed-pa",totalDownloads:1266,totalCrossrefCites:5,totalDimensionsCites:5,abstract:"The present review describes a part of the author’s own experience in applying immunoperoxidase staining to routine histopathological diagnosis. The target disorder was focused on infection. In the practice of pathology diagnosis services, it is important for us diagnostic pathologists to judge whether the lesion is caused by an infection or not. When an infectious disease is highly likely, the visualization of pathogens within the inflammatory lesion is required to suggest a causative agent. Two main approaches the author would like to introduce include (1) the use of commercially available antisera showing wide cross-reactivity to a variety of bacteria and (2) the use of diluted patients’ sera. These immunohistochemical studies employing “low-specificity” and “high-sensitivity” probes are useful for confirming the localization of pathogen within the infectious lesion.",book:{id:"7013",slug:"immunohistochemistry-the-ageless-biotechnology",title:"Immunohistochemistry",fullTitle:"Immunohistochemistry - The Ageless Biotechnology"},signatures:"Yutaka Tsutsumi",authors:[{id:"280338",title:"Dr.",name:"Yutaka",middleName:null,surname:"Tsutsumi",slug:"yutaka-tsutsumi",fullName:"Yutaka Tsutsumi"}]},{id:"78305",title:"Anti-Microbial Peptides: The Importance of Structure-Function Analysis in the Design of New AMPs",slug:"anti-microbial-peptides-the-importance-of-structure-function-analysis-in-the-design-of-new-amps",totalDownloads:53,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"In recent years the rapid emergence of drug resistant microorganisms has become a major health problem worldwide. The number of multidrug resistant (MDR) bacteria is in a rapid increase. Therefore, there is an urgent need to develop new antimicrobial agent that is active against MDR. Among the possible candidates, antimicrobial peptides (AMPs) represent a promising alternative. Many AMPs candidates were in clinical development and the Nisin was approved in many food products. Exact mechanism of AMPs action has not been fully elucidated. More comprehensive of the mechanism of action provide a path towards overcoming the toxicity limitation. This chapter is a review that provides an overview of bacterial AMPs named bacteriocin, focusing on their diverse mechanism of action. We develop here the structure–function relationship of many AMPs. A good understanding of AMPS structure–function relationship can helps the scientific in the conception of new active AMPs by the evaluation of the role of each residue and the determination of the essential amino acids for activity. This feature helps the development of the second-generation AMPs with high potential antimicrobial activity and more.",book:{id:"10874",slug:null,title:"Insights on Antimicrobial Peptides",fullTitle:"Insights on Antimicrobial Peptides"},signatures:"Awatef Ouertani, Amor Mosbah and Ameur Cherif",authors:null}],onlineFirstChaptersFilter:{topicId:"149",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"80915",title:"Molecular Pathogenesis of Inflammatory Cytokines in Insulin Resistance Diabetes Mellitus",slug:"molecular-pathogenesis-of-inflammatory-cytokines-in-insulin-resistance-diabetes-mellitus",totalDownloads:13,totalDimensionsCites:0,doi:"10.5772/intechopen.100971",abstract:"Diabetes Mellitus Type 2 (T2DM) is a non-communicable and multifactorial disease. It is a leading cause of premature deaths worldwide. Inflammatory cytokines are reported that they have potential to enhance insulin resistance and hence T2DM. The current research was taken to investigate the possible role of inflammatory mediators: Tumor Necrosis Factor (TNF-α) and White blood cells (WBC’s) in mobilizing biological molecules mainly immunological nature. A total of 320 subjects were selected in this study among them 160 were T2DM cases and 160 were healthy controls. Serum concentration of Tumor Necrosis Factor-a (TNF-α) was quantified by ELISA method, WBC count was measured on Sysmax (Germany) hematology analyzer, biochemical and Immunoassay parameters were done on fully automatic analyzers. The expression of candidate pro-inflammatory cytokine (TNF-α), and (WBC’s) were elevated in T2DM. TNF-α shows association (p<0.001) with glycemic profile and insulin sensitivity in T2DM cases in comparison with healthy controls. Induction of inflammation and up regulation of pro-inflammatory cytokines has been purported to play a significant role in pathogenesis of T2DM and study confirms that the positive correlation of TNF-α with T2DM and hence to insulin sensitivity. These can act as early prediction biomarkers in diagnosis and prognosis of human disease i.e Diabetes Mellitus. Further studies are needed to help clinicians manage and treat T2DM effectively.",book:{id:"10874",title:"Insights on Antimicrobial Peptides",coverURL:"https://cdn.intechopen.com/books/images_new/10874.jpg"},signatures:"Haamid Bashir, Mohammad Hayat Bhat and Sabhiya Majid"},{id:"81299",title:"Peptides with Therapeutic Potential against Acinetobacter baumanii Infections",slug:"peptides-with-therapeutic-potential-against-em-acinetobacter-baumanii-em-infections",totalDownloads:25,totalDimensionsCites:0,doi:"10.5772/intechopen.100389",abstract:"Antibiotic poly-resistance (multi drug-, extreme-, and pan-drug resistance) is a major global threat to public health. Unfortunately, in 2017, the World Health Organization (WHO) introduced the carbapenemresistant isolates in the priority pathogens list for which new effective antibiotics or new ways of treating the infections caused by them are urgently needed. Acinetobacter baumannii is one of the most critical ESKAPE pathogens for which the treatment of resistant isolates have caused severe problems; its clinically significant features include resistance to UV light, drying, disinfectants, and antibiotics. Among the various suggested options, one of the antimicrobial agents with high potential to produce new anti-Acinetobacter drugs is the antimicrobial peptides (AMPs). AMPs are naturally produced by living organisms and protect the host against pathogens as a part of innate immunity. The main mechanisms action of AMPs are the ability to cause cell membrane and cell wall damage, the inhibition of protein synthesis, nucleic acids, and the induction of apoptosis and necrosis. AMPs would be likely among the main anti-A. baumannii drugs in the post-antibiotic era. Also, the application of computer science to increase anti-A. baumannii activity and reduce toxicity is also being developed.",book:{id:"10874",title:"Insights on Antimicrobial Peptides",coverURL:"https://cdn.intechopen.com/books/images_new/10874.jpg"},signatures:"Karyne Rangel and Salvatore Giovanni De-Simone"},{id:"78305",title:"Anti-Microbial Peptides: The Importance of Structure-Function Analysis in the Design of New AMPs",slug:"anti-microbial-peptides-the-importance-of-structure-function-analysis-in-the-design-of-new-amps",totalDownloads:59,totalDimensionsCites:0,doi:"10.5772/intechopen.99801",abstract:"In recent years the rapid emergence of drug resistant microorganisms has become a major health problem worldwide. The number of multidrug resistant (MDR) bacteria is in a rapid increase. Therefore, there is an urgent need to develop new antimicrobial agent that is active against MDR. Among the possible candidates, antimicrobial peptides (AMPs) represent a promising alternative. Many AMPs candidates were in clinical development and the Nisin was approved in many food products. Exact mechanism of AMPs action has not been fully elucidated. More comprehensive of the mechanism of action provide a path towards overcoming the toxicity limitation. This chapter is a review that provides an overview of bacterial AMPs named bacteriocin, focusing on their diverse mechanism of action. We develop here the structure–function relationship of many AMPs. A good understanding of AMPS structure–function relationship can helps the scientific in the conception of new active AMPs by the evaluation of the role of each residue and the determination of the essential amino acids for activity. This feature helps the development of the second-generation AMPs with high potential antimicrobial activity and more.",book:{id:"10874",title:"Insights on Antimicrobial Peptides",coverURL:"https://cdn.intechopen.com/books/images_new/10874.jpg"},signatures:"Awatef Ouertani, Amor Mosbah and Ameur Cherif"},{id:"79192",title:"Mass Spectrometry (Imaging) for Detection and Identification of Cyclic AMPs: Focus on Human Neutrophil Peptides (HNPs)",slug:"mass-spectrometry-imaging-for-detection-and-identification-of-cyclic-amps-focus-on-human-neutrophil-",totalDownloads:71,totalDimensionsCites:0,doi:"10.5772/intechopen.99251",abstract:"Antimicrobial peptides (AMPs) are known best for their role in innate immunity against bacteria, viruses, parasites and fungi. However, not only are they showing increasing promise as potential antimicrobial drug candidates, recently, it has been reported that certain AMPs also show a cytotoxic effect against cancer cells. Their possible antitumor effect could make AMPs interesting candidate cancer biomarkers and a possible lead for new anticancer therapy. Due to their cyclic structure, detection and identification of AMPs is challenging, however, mass spectrometry (imaging; MSI) has been shown as a powerful tool for visualization and identification of (unknown) cyclic AMPs. In this chapter, we will discuss how mass spectrometry (imaging), combined with the use of electron-transfer dissociation (ETD) as fragmentation technique, can be used as a reliable method to identify AMPs in their native cyclic state. Using this approach, we have previously detected and identified human neutrophil peptides (HNPs) as important AMPs in cancer, of which a detailed bacterial, viral and cancer-related overview will be presented.",book:{id:"10874",title:"Insights on Antimicrobial Peptides",coverURL:"https://cdn.intechopen.com/books/images_new/10874.jpg"},signatures:"Eline Berghmans and Geert Baggerman"},{id:"78302",title:"Antimicrobial Peptides Derived from Ascidians and Associated Cyanobacteria",slug:"antimicrobial-peptides-derived-from-ascidians-and-associated-cyanobacteria",totalDownloads:74,totalDimensionsCites:0,doi:"10.5772/intechopen.99183",abstract:"Ascidians belonging to Phylum Chordata are the most largest and diverse of the Sub-phylum Tunicata (Urochordata). Marine ascidians are one of the richest sources of bioactive peptides. These bioactive peptides from marine ascidians are confined to various types of structures such as cyclic peptides, acyclic peptides (depsipeptides), linear helical peptides with abundance of one amino acid (proline, trytophane, histidine), peptides forming hairpin like beta sheets or α-helical/β-sheet mixed structures stabilized by intra molecular disulfide bonding. Cyanobactins are fabricated through the proteolytic cleavage and cyclization of precursor peptides coupled with further posttranslational modifications such as hydroxylation, glycosylation, heterocyclization, oxidation, or prenylation of amino acids. Ascidians are known to be a rich source of bioactive alkaloids. β-carbolines form a large group of tryptophan derived antibiotics. Pyridoacridines from ascidians are tetra- or penta- cyclic aromatic alkaloids with broad range of bioactivities. Didemnidines derived from ascidian symbiotic microbes are inhibitors of phospholipase A2 and induce cell apoptosis. Meridianins are indulged in inhibiting various protein kinases such as, cyclindependent kinases, glycogen synthase kinase-3, cyclic nucleotide dependent kinases, casein kinase, and also implicate their activity of interfering with topoisomerase, altering the mitochondrial membrane potential and binding to the DNA minor groove to inhibit transcriptional activation. Most of these bioactive compounds from ascidians are already in different phases of the clinical and pre-clinical trials. They can be used for their nutraceutical values because of their antineoplastic, antihypertensive, antioxidant, antimicrobial, cytotoxic, antibacterial, antifungal, insecticidal, anti-HIV and anti-parasitic, anti-malarial, anti-trypanosomal, anti-cancer etc. This chapter mostly deals with antibacterial compounds from ascidian and their associate symbiotic cyanobacteria.",book:{id:"10874",title:"Insights on Antimicrobial Peptides",coverURL:"https://cdn.intechopen.com/books/images_new/10874.jpg"},signatures:"Rajaian Pushpabai Rajesh and Grace Vanathi M"}],onlineFirstChaptersTotal:5},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"June 11th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"27",title:"Multi-Agent Systems",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",isOpenForSubmission:!0,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. He has served as guest editor for a number of special issues of peer-reviewed international journals.",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:19,paginationItems:[{id:"82196",title:"Multi-Features Assisted Age Invariant Face Recognition and Retrieval Using CNN with Scale Invariant Heat Kernel Signature",doi:"10.5772/intechopen.104944",signatures:"Kamarajugadda Kishore Kumar and Movva Pavani",slug:"multi-features-assisted-age-invariant-face-recognition-and-retrieval-using-cnn-with-scale-invariant-",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"82063",title:"Evaluating Similarities and Differences between Machine Learning and Traditional Statistical Modeling in Healthcare Analytics",doi:"10.5772/intechopen.105116",signatures:"Michele Bennett, Ewa J. Kleczyk, Karin Hayes and Rajesh Mehta",slug:"evaluating-similarities-and-differences-between-machine-learning-and-traditional-statistical-modelin",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Machine Learning and Data Mining - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11422.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"81791",title:"Self-Supervised Contrastive Representation Learning in Computer Vision",doi:"10.5772/intechopen.104785",signatures:"Yalin Bastanlar and Semih Orhan",slug:"self-supervised-contrastive-representation-learning-in-computer-vision",totalDownloads:30,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"79345",title:"Application of Jump Diffusion Models in Insurance Claim Estimation",doi:"10.5772/intechopen.99853",signatures:"Leonard Mushunje, Chiedza Elvina Mashiri, Edina Chandiwana and Maxwell Mashasha",slug:"application-of-jump-diffusion-models-in-insurance-claim-estimation-1",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}}]},overviewPagePublishedBooks:{paginationCount:9,paginationItems:[{type:"book",id:"7723",title:"Artificial Intelligence",subtitle:"Applications in Medicine and Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7723.jpg",slug:"artificial-intelligence-applications-in-medicine-and-biology",publishedDate:"July 31st 2019",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"a3852659e727f95c98c740ed98146011",volumeInSeries:1,fullTitle:"Artificial Intelligence - Applications in Medicine and Biology",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}]},{type:"book",id:"7726",title:"Swarm Intelligence",subtitle:"Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/7726.jpg",slug:"swarm-intelligence-recent-advances-new-perspectives-and-applications",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Javier Del Ser, Esther Villar and Eneko Osaba",hash:"e7ea7e74ce7a7a8e5359629e07c68d31",volumeInSeries:2,fullTitle:"Swarm Intelligence - Recent Advances, New Perspectives and Applications",editors:[{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null}]},{type:"book",id:"7656",title:"Fuzzy Logic",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7656.jpg",slug:"fuzzy-logic",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Constantin Volosencu",hash:"54f092d4ffe0abf5e4172a80025019bc",volumeInSeries:3,fullTitle:"Fuzzy Logic",editors:[{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",institutionURL:null,country:{name:"Romania"}}}]},{type:"book",id:"9963",title:"Advances and Applications in Deep Learning",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9963.jpg",slug:"advances-and-applications-in-deep-learning",publishedDate:"December 9th 2020",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"0d51ba46f22e55cb89140f60d86a071e",volumeInSeries:4,fullTitle:"Advances and Applications in Deep Learning",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}]}]},openForSubmissionBooks:{paginationCount:3,paginationItems:[{id:"11578",title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",hash:"3731c009f474c6ed4293f348ca7b27ac",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"June 3rd 2022",isOpenForSubmission:!0,editors:[{id:"225390",title:"Dr.",name:"Asghar Ali",surname:"Kamboh",slug:"asghar-ali-kamboh",fullName:"Asghar Ali Kamboh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"12086",title:"Cattle Diseases - Molecular and Biochemical Approach",coverURL:"https://cdn.intechopen.com/books/images_new/12086.jpg",hash:"afdbf57e32d996556a94528c06623cf3",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 5th 2022",isOpenForSubmission:!0,editors:[{id:"219081",title:"Dr.",name:"Abdulsamed",surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11579",title:"Animal Welfare - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11579.jpg",hash:"12e4f41264cbe99028655e5463fa941a",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 8th 2022",isOpenForSubmission:!0,editors:[{id:"51520",title:"Dr.",name:"Shao-Wen",surname:"Hung",slug:"shao-wen-hung",fullName:"Shao-Wen Hung"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:36,paginationItems:[{id:"82195",title:"Endoplasmic Reticulum: A Hub in Lipid Homeostasis",doi:"10.5772/intechopen.105450",signatures:"Raúl Ventura and María Isabel Hernández-Alvarez",slug:"endoplasmic-reticulum-a-hub-in-lipid-homeostasis",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82409",title:"Purinergic Signaling in Covid-19 Disease",doi:"10.5772/intechopen.105008",signatures:"Hailian Shen",slug:"purinergic-signaling-in-covid-19-disease",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82374",title:"The Potential of the Purinergic System as a Therapeutic Target of Natural Compounds in Cutaneous Melanoma",doi:"10.5772/intechopen.105457",signatures:"Gilnei Bruno da Silva, Daiane Manica, Marcelo Moreno and Margarete Dulce Bagatini",slug:"the-potential-of-the-purinergic-system-as-a-therapeutic-target-of-natural-compounds-in-cutaneous-mel",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82103",title:"The Role of Endoplasmic Reticulum Stress and Its Regulation in the Progression of Neurological and Infectious Diseases",doi:"10.5772/intechopen.105543",signatures:"Mary Dover, Michael Kishek, Miranda Eddins, Naneeta Desar, Ketema Paul and Milan Fiala",slug:"the-role-of-endoplasmic-reticulum-stress-and-its-regulation-in-the-progression-of-neurological-and-i",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82212",title:"Protein Prenylation and Their Applications",doi:"10.5772/intechopen.104700",signatures:"Khemchand R. Surana, Ritesh B. Pawar, Ritesh A. Khairnar and Sunil K. Mahajan",slug:"protein-prenylation-and-their-applications",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Modifications of Biomolecules",coverURL:"https://cdn.intechopen.com/books/images_new/11098.jpg",subseries:null}},{id:"80954",title:"Ion Channels and Neurodegenerative Disease Aging Related",doi:"10.5772/intechopen.103074",signatures:"Marika Cordaro, Salvatore Cuzzocrea and Rosanna Di Paola",slug:"ion-channels-and-neurodegenerative-disease-aging-related",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82096",title:"An Important Component of Tumor Progression: Fatty Acids",doi:"10.5772/intechopen.105087",signatures:"Jin Wang, Qifei Wang and Guangzhen Wu",slug:"an-important-component-of-tumor-progression-fatty-acids",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82029",title:"Synthesis, Characterization and Antimicrobial Properties of Novel Benzimidazole Amide Derivatives Bearing Thiophene Moiety",doi:"10.5772/intechopen.104908",signatures:"Vinayak Adimule, Pravin Kendrekar and Sheetal Batakurki",slug:"synthesis-characterization-and-antimicrobial-properties-of-novel-benzimidazole-amide-derivatives-bea",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Benzimidazole",coverURL:"https://cdn.intechopen.com/books/images_new/10840.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"81927",title:"Purinergic System in Immune Response",doi:"10.5772/intechopen.104485",signatures:"Yerly Magnolia Useche Salvador",slug:"purinergic-system-in-immune-response",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"80495",title:"Iron in Cell Metabolism and Disease",doi:"10.5772/intechopen.101908",signatures:"Eeka Prabhakar",slug:"iron-in-cell-metabolism-and-disease",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}}]},subseriesFiltersForOFChapters:[{caption:"Proteomics",value:18,count:1,group:"subseries"},{caption:"Chemical Biology",value:15,count:5,group:"subseries"},{caption:"Metabolism",value:17,count:13,group:"subseries"},{caption:"Cell and Molecular Biology",value:14,count:15,group:"subseries"}],publishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"10795",title:"Plant Stress Physiology",subtitle:"Perspectives in Agriculture",coverURL:"https://cdn.intechopen.com/books/images_new/10795.jpg",slug:"plant-stress-physiology-perspectives-in-agriculture",publishedDate:"April 28th 2022",editedByType:"Edited by",bookSignature:"Mirza Hasanuzzaman and Kamran Nahar",hash:"c5a7932b74fe612b256bf95d0709756e",volumeInSeries:11,fullTitle:"Plant Stress Physiology - Perspectives in Agriculture",editors:[{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",institutionURL:null,country:{name:"Bangladesh"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7999",title:"Free Radical Medicine and Biology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7999.jpg",slug:"free-radical-medicine-and-biology",publishedDate:"July 15th 2020",editedByType:"Edited by",bookSignature:"Kusal Das, Swastika Das, Mallanagouda Shivanagouda Biradar, Varaprasad Bobbarala and S. Subba Tata",hash:"083e5d427097d368a3f8a02bd6c76bf8",volumeInSeries:10,fullTitle:"Free Radical Medicine and Biology",editors:[{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8762",title:"Melatonin",subtitle:"The Hormone of Darkness and its Therapeutic Potential and Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/8762.jpg",slug:"melatonin-the-hormone-of-darkness-and-its-therapeutic-potential-and-perspectives",publishedDate:"June 24th 2020",editedByType:"Edited by",bookSignature:"Marilena Vlachou",hash:"bfbc5538173f11acb0f9549a85b70489",volumeInSeries:9,fullTitle:"Melatonin - The Hormone of Darkness and its Therapeutic Potential and Perspectives",editors:[{id:"246279",title:"Associate Prof.",name:"Marilena",middleName:null,surname:"Vlachou",slug:"marilena-vlachou",fullName:"Marilena Vlachou",profilePictureURL:"https://mts.intechopen.com/storage/users/246279/images/system/246279.jpg",institutionString:"National and Kapodistrian University of Athens",institution:{name:"National and Kapodistrian University of Athens",institutionURL:null,country:{name:"Greece"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8002",title:"Tumor Progression and Metastasis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8002.jpg",slug:"tumor-progression-and-metastasis",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Ahmed Lasfar and Karine Cohen-Solal",hash:"db17b0fe0a9b6e80ff02b81a93bafa4e",volumeInSeries:8,fullTitle:"Tumor Progression and Metastasis",editors:[{id:"32546",title:"Dr.",name:"Ahmed",middleName:null,surname:"Lasfar",slug:"ahmed-lasfar",fullName:"Ahmed Lasfar",profilePictureURL:"https://mts.intechopen.com/storage/users/32546/images/system/32546.png",institutionString:"Rutgers, The State University of New Jersey",institution:{name:"Rutgers, The State University of New Jersey",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6897",title:"Biophysical Chemistry",subtitle:"Advance Applications",coverURL:"https://cdn.intechopen.com/books/images_new/6897.jpg",slug:"biophysical-chemistry-advance-applications",publishedDate:"February 19th 2020",editedByType:"Edited by",bookSignature:"Mohammed A. A. Khalid",hash:"0ad18ab382e2ffb9ff202d15282297eb",volumeInSeries:7,fullTitle:"Biophysical Chemistry - Advance Applications",editors:[{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",institutionString:"Taif University",institution:{name:"Taif University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8430",title:"Neurodevelopment and Neurodevelopmental Disorder",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8430.jpg",slug:"neurodevelopment-and-neurodevelopmental-disorder",publishedDate:"November 27th 2019",editedByType:"Edited by",bookSignature:"Michael Fitzgerald",hash:"696c96d038de473216e48b199613c111",volumeInSeries:6,fullTitle:"Neurodevelopment and Neurodevelopmental Disorder",editors:[{id:"205005",title:"Dr.",name:"Michael",middleName:null,surname:"Fitzgerald",slug:"michael-fitzgerald",fullName:"Michael Fitzgerald",profilePictureURL:"https://mts.intechopen.com/storage/users/205005/images/system/205005.jpg",institutionString:"Independant Researcher",institution:{name:"Trinity College Dublin",institutionURL:null,country:{name:"Ireland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8008",title:"Antioxidants",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8008.jpg",slug:"antioxidants",publishedDate:"November 6th 2019",editedByType:"Edited by",bookSignature:"Emad Shalaby",hash:"76361b4061e830906267933c1c670027",volumeInSeries:5,fullTitle:"Antioxidants",editors:[{id:"63600",title:"Prof.",name:"Emad",middleName:null,surname:"Shalaby",slug:"emad-shalaby",fullName:"Emad Shalaby",profilePictureURL:"https://mts.intechopen.com/storage/users/63600/images/system/63600.png",institutionString:"Cairo University",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8797",title:"Adipose Tissue",subtitle:"An Update",coverURL:"https://cdn.intechopen.com/books/images_new/8797.jpg",slug:"adipose-tissue-an-update",publishedDate:"November 6th 2019",editedByType:"Edited by",bookSignature:"Leszek Szablewski",hash:"34880b7b450ef96fa5063c867c028b02",volumeInSeries:4,fullTitle:"Adipose Tissue - An Update",editors:[{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",institutionString:"University of Pécs",institution:{name:"University of Pecs",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7264",title:"Calcium and Signal Transduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7264.jpg",slug:"calcium-and-signal-transduction",publishedDate:"October 24th 2018",editedByType:"Edited by",bookSignature:"John N. Buchholz and Erik J. Behringer",hash:"e373a3d1123dbd45fddf75d90e3e7c38",volumeInSeries:1,fullTitle:"Calcium and Signal Transduction",editors:[{id:"89438",title:"Dr.",name:"John N.",middleName:null,surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Plant Physiology",value:13,count:1},{group:"subseries",caption:"Human Physiology",value:12,count:2},{group:"subseries",caption:"Cell Physiology",value:11,count:8}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1},{group:"publicationYear",caption:"2020",value:2020,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:250,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"1",type:"subseries",title:"Oral Health",keywords:"Oral health, Dental care, Diagnosis, Diagnostic imaging, Early diagnosis, Oral cancer, Conservative treatment, Epidemiology, Comprehensive dental care, Complementary therapies, Holistic health",scope:"\r\n This topic aims to provide a comprehensive overview of the latest trends in Oral Health based on recent scientific evidence. Subjects will include an overview of oral diseases and infections, systemic diseases affecting the oral cavity, prevention, diagnosis, treatment, epidemiology, as well as current clinical recommendations for the management of oral, dental, and periodontal diseases.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/1.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11397,editor:{id:"173955",title:"Prof.",name:"Sandra",middleName:null,surname:"Marinho",slug:"sandra-marinho",fullName:"Sandra Marinho",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGYMQA4/Profile_Picture_2022-06-01T13:22:41.png",biography:"Dr. Sandra A. Marinho is an Associate Professor and Brazilian researcher at the State University of Paraíba (Universidade Estadual da Paraíba- UEPB), Campus VIII, located in Araruna, state of Paraíba since 2011. She holds a degree in Dentistry from the Federal University of Alfenas (UNIFAL), while her specialization and professional improvement in Stomatology took place at Hospital Heliopolis (São Paulo, SP). Her qualifications are: a specialist in Dental Imaging and Radiology, Master in Dentistry (Periodontics) from the University of São Paulo (FORP-USP, Ribeirão Preto, SP), and Doctor (Ph.D.) in Dentistry (Stomatology Clinic) from Hospital São Lucas of the Pontifical Catholic University of Rio Grande do Sul (HSL-PUCRS, Porto Alegre, RS). She held a postdoctoral internship at the Federal University from Jequitinhonha and Mucuri Valleys (UFVJM, Diamantina, MG). She is currently a member of the Brazilian Society for Dental Research (SBPqO) and the Brazilian Society of Stomatology and Pathology (SOBEP). Dr. Marinho's experience in Dentistry mainly covers the following subjects: oral diagnosis, oral radiology; oral medicine; lesions and oral infections; oral pathology, laser therapy and epidemiological studies.",institutionString:null,institution:{name:"State University of Paraíba",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,series:{id:"3",title:"Dentistry",doi:"10.5772/intechopen.71199",issn:"2631-6218"},editorialBoard:[{id:"267724",title:"Dr.",name:"Febronia",middleName:null,surname:"Kahabuka",slug:"febronia-kahabuka",fullName:"Febronia Kahabuka",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZpJQAW/Profile_Picture_2022-06-27T12:00:42.JPG",institutionString:null,institution:null}]},onlineFirstChapters:{paginationCount:13,paginationItems:[{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. Drury",slug:"new-and-emerging-technologies-for-integrative-ambulatory-autonomic-assessment-and-intervention-as-a-",totalDownloads:18,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"81286",title:"Potassium Derangements: A Pathophysiological Review, Diagnostic Approach, and Clinical Management",doi:"10.5772/intechopen.103016",signatures:"Sairah Sharif and Jie Tang",slug:"potassium-derangements-a-pathophysiological-review-diagnostic-approach-and-clinical-management",totalDownloads:41,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80895",title:"Heart Rate Variability as a Marker of Homeostatic Level",doi:"10.5772/intechopen.102500",signatures:"Moacir Fernandes de Godoy and Michele Lima Gregório",slug:"heart-rate-variability-as-a-marker-of-homeostatic-level",totalDownloads:36,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Moacir",surname:"Godoy"},{name:"Michele",surname:"Gregório"}],book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80433",title:"Heart Autonomic Nervous System: Basic Science and Clinical Implications",doi:"10.5772/intechopen.101718",signatures:"Elvan Wiyarta and Nayla Karima",slug:"heart-autonomic-nervous-system-basic-science-and-clinical-implications",totalDownloads:71,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80316",title:"Central Control of the Larynx in Mammals",doi:"10.5772/intechopen.102009",signatures:"Manuel Víctor López-González, Marta González-García, Laura Carrillo-Franco, Amelia Díaz-Casares and Marc Stefan Dawid-Milner",slug:"central-control-of-the-larynx-in-mammals",totalDownloads:46,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80402",title:"General Anesthesia and Autonomic Nervous System: Control and Management in Neurosurgery",doi:"10.5772/intechopen.101829",signatures:"Irina Alexandrovna Savvina, Anna Olegovna Petrova and Yulia Mikhailovna Zabrodskaya",slug:"general-anesthesia-and-autonomic-nervous-system-control-and-management-in-neurosurgery",totalDownloads:71,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80035",title:"Healthy Lifestyle, Autonomic Nervous System Activity, and Sleep Status for Healthy Aging",doi:"10.5772/intechopen.101837",signatures:"Miki Sato, Feni Betriana, Ryuichi Tanioka, Kyoko Osaka, Tetsuya Tanioka and Savina Schoenhofer",slug:"healthy-lifestyle-autonomic-nervous-system-activity-and-sleep-status-for-healthy-aging",totalDownloads:74,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80175",title:"Signaling Pathways Regulating Axogenesis and Dendritogenesis in Sympathetic Neurons",doi:"10.5772/intechopen.102442",signatures:"Vidya Chandrasekaran",slug:"signaling-pathways-regulating-axogenesis-and-dendritogenesis-in-sympathetic-neurons",totalDownloads:75,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Vidya",surname:"Chandrasekaran"}],book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80176",title:"Impacts of Environmental Stressors on Autonomic Nervous System",doi:"10.5772/intechopen.101842",signatures:"Mayowa Adeniyi",slug:"impacts-of-environmental-stressors-on-autonomic-nervous-system",totalDownloads:77,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"79655",title:"The Autonomic Nervous System, Sex Differences, and Chronobiology under General Anesthesia in In Vivo Experiments Involving Rats",doi:"10.5772/intechopen.101075",signatures:"Pavol Svorc Jr and Pavol Svorc",slug:"the-autonomic-nervous-system-sex-differences-and-chronobiology-under-general-anesthesia-in-in-vivo-e",totalDownloads:99,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"79194",title:"Potassium in Solid Cancers",doi:"10.5772/intechopen.101108",signatures:"Jessica Iorio, Lisa Lastraioli and Elena Lastraioli",slug:"potassium-in-solid-cancers",totalDownloads:158,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"78820",title:"Potassium Homeostasis",doi:"10.5772/intechopen.100368",signatures:"Shakuntala S. Patil and Sachin M. Patil",slug:"potassium-homeostasis",totalDownloads:120,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"78193",title:"Potassium and Cardiac Surgery",doi:"10.5772/intechopen.99735",signatures:"Shawn Kant, Frank W. Sellke and Jun Feng",slug:"potassium-and-cardiac-surgery",totalDownloads:203,totalCrossrefCites:1,totalDimensionsCites:1,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}}]},publishedBooks:{paginationCount:2,paginationItems:[{type:"book",id:"9883",title:"Biosensors",subtitle:"Current and Novel Strategies for Biosensing",coverURL:"https://cdn.intechopen.com/books/images_new/9883.jpg",slug:"biosensors-current-and-novel-strategies-for-biosensing",publishedDate:"May 5th 2021",editedByType:"Edited by",bookSignature:"Luis Jesús Villarreal-Gómez and Ana Leticia Iglesias",hash:"028f3e5dbf9c32590183ac4b4f0a2825",volumeInSeries:11,fullTitle:"Biosensors - Current and Novel Strategies for Biosensing",editors:[{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6843",title:"Biomechanics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6843.jpg",slug:"biomechanics",publishedDate:"January 30th 2019",editedByType:"Edited by",bookSignature:"Hadi Mohammadi",hash:"85132976010be1d7f3dbd88662b785e5",volumeInSeries:4,fullTitle:"Biomechanics",editors:[{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"14",title:"Cell and Molecular Biology",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression"},{id:"15",title:"Chemical Biology",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors"},{id:"17",title:"Metabolism",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation"},{id:"18",title:"Proteomics",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/305926",hash:"",query:{},params:{id:"305926"},fullPath:"/profiles/305926",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()