Comparative analysis of cloud portability issues.
\\n\\n
These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\\n\\n\\n\\n\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10881",leadTitle:null,fullTitle:"Drug Repurposing - Molecular Aspects and Therapeutic Applications",title:"Drug Repurposing",subtitle:"Molecular Aspects and Therapeutic Applications",reviewType:"peer-reviewed",abstract:"This book focuses on various aspects and applications of drug repurposing, the understanding of which is important for treating diseases. Due to the high costs and time associated with the new drug discovery process, the inclination toward drug repurposing is increasing for common as well as rare diseases. A major focus of this book is understanding the role of drug repurposing to develop drugs for infectious diseases, including antivirals, antibacterial and anticancer drugs, as well as immunotherapeutics.",isbn:"978-1-83969-958-0",printIsbn:"978-1-83969-957-3",pdfIsbn:"978-1-83969-959-7",doi:null,price:139,priceEur:155,priceUsd:179,slug:"drug-repurposing-molecular-aspects-and-therapeutic-applications",numberOfPages:384,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"eca3f2d5ca97b457d38a2442b36d3ac7",bookSignature:"Shailendra K. Saxena",publishedDate:"June 1st 2022",coverURL:"https://cdn.intechopen.com/books/images_new/10881.jpg",numberOfDownloads:2261,numberOfWosCitations:0,numberOfCrossrefCitations:6,numberOfCrossrefCitationsByBook:null,numberOfDimensionsCitations:11,numberOfDimensionsCitationsByBook:null,hasAltmetrics:0,numberOfTotalCitations:17,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 1st 2021",dateEndSecondStepPublish:"August 3rd 2021",dateEndThirdStepPublish:"September 7th 2021",dateEndFourthStepPublish:"November 26th 2021",dateEndFifthStepPublish:"January 25th 2022",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"14",totalChapterViews:"0",totalEditedBooks:"9",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1195",title:"Drug Discovery",slug:"pharmacology-toxicology-and-pharmaceutical-science-pharmacology-drug-discovery"}],chapters:[{id:"79463",title:"Trends in Molecular Aspects and Therapeutic Applications of Drug Repurposing for Infectious Diseases",doi:"10.5772/intechopen.100858",slug:"trends-in-molecular-aspects-and-therapeutic-applications-of-drug-repurposing-for-infectious-diseases",totalDownloads:74,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"The pharmaceutical industry has undergone a severe economic crunch in antibiotic discovery research due to evolving bacterial resistance along with enormous time and money that gets consumed in de novo drug design and discovery strategies. Nevertheless, drug repurposing has evolved as an economically safer and excellent alternative strategy to identify approved drugs for new therapeutic indications. Virtual high throughput screening (vHTS) and phenotype-based high throughput screening (HTS) of approved molecules play a crucial role in identifying, developing, and repurposing old drug molecules into anti-infective agents either alone or in synergistic combination with antibiotic therapy. This chapter briefly explains the process of drug repurposing/repositioning in comparison to de novo methods utilizing vHTS and HTS technologies along with ‘omics- and poly-pharmacology-based drug repurposing strategies in the identification and development of anti-microbial agents. This chapter also gives an insightful survey of the intellectual property landscape on drug repurposing. Further, the challenges and applications of drug repurposing strategies in the discovery of anti-infective drugs are exemplified. The future perspectives of drug repurposing in the context of anti-infective agents are also discussed.",signatures:"Ankur Gupta, Angila Theengh, Swatantra Kumar, Vimal K. Maurya, Santosh Kumar, Bipin Puri and Shailendra K. Saxena",downloadPdfUrl:"/chapter/pdf-download/79463",previewPdfUrl:"/chapter/pdf-preview/79463",authors:[{id:"158026",title:"Prof.",name:"Shailendra K.",surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena"},{id:"440393",title:"Dr.",name:"Ankur",surname:"Gupta",slug:"ankur-gupta",fullName:"Ankur Gupta"},{id:"440394",title:"Dr.",name:"Angila",surname:"Theengh",slug:"angila-theengh",fullName:"Angila Theengh"},{id:"440395",title:"Dr.",name:"Swatantra",surname:"Kumar",slug:"swatantra-kumar",fullName:"Swatantra Kumar"},{id:"440396",title:"Dr.",name:"Vimal K.",surname:"Maurya",slug:"vimal-k.-maurya",fullName:"Vimal K. Maurya"},{id:"440397",title:"Dr.",name:"Santosh",surname:"Kumar",slug:"santosh-kumar",fullName:"Santosh Kumar"},{id:"440398",title:"Dr.",name:"Bipin",surname:"Puri",slug:"bipin-puri",fullName:"Bipin Puri"}],corrections:null},{id:"79878",title:"Evaluation of Drug Repositioning by Molecular Docking of Pharmaceutical Resources to Identification of Potential SARS-CoV-2 Viral Inhibitors",doi:"10.5772/intechopen.101395",slug:"evaluation-of-drug-repositioning-by-molecular-docking-of-pharmaceutical-resources-to-identification-",totalDownloads:116,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Unfortunately, to date, there is no approved specific antiviral drug treatment against COVID-19. Due to the costly and time-consuming nature of the de novo drug discovery and development process, in recent days, the computational drug repositioning method has been highly regarded for accelerating the drug-discovery process. The selection of drug target molecule(s), preparation of an approved therapeutics agent library, and in silico evaluation of their affinity to the subjected target(s) are the main steps of a molecular docking-based drug repositioning process, which is the most common computational drug re-tasking process. In this chapter, after a review on origin, pathophysiology, molecular biology, and drug development strategies against COVID-19, recent advances, challenges as well as the future perspective of molecular docking-based drug repositioning for COVID-19 are discussed. Furthermore, as a case study, the molecular docking-based drug repurposing process was planned to screen the 3CLpro inhibitor(s) among the nine Food and Drug Administration (FDA)-approved antiviral protease inhibitors. The results demonstrated that Fosamprenavir had the highest binding affinity to 3CLpro and can be considered for more in silico, in vitro, and in vivo evaluations as an effective repurposed anti-COVID-19 drug.",signatures:"Fatemeh Hosseini, Mehrdad Azin, Hamideh Ofoghi and Tahereh Alinejad",downloadPdfUrl:"/chapter/pdf-download/79878",previewPdfUrl:"/chapter/pdf-preview/79878",authors:[{id:"347334",title:"MSc.",name:"Fatemeh",surname:"Hosseini",slug:"fatemeh-hosseini",fullName:"Fatemeh Hosseini"},{id:"435798",title:"Prof.",name:"Mehrdad",surname:"Azin",slug:"mehrdad-azin",fullName:"Mehrdad Azin"},{id:"435799",title:"Dr.",name:"Hamideh",surname:"Ofoghi",slug:"hamideh-ofoghi",fullName:"Hamideh Ofoghi"},{id:"435800",title:"Dr.",name:"Tahereh",surname:"Alinejad",slug:"tahereh-alinejad",fullName:"Tahereh Alinejad"}],corrections:null},{id:"79867",title:"Drug Repurposing Techniques in Viral Diseases",doi:"10.5772/intechopen.101443",slug:"drug-repurposing-techniques-in-viral-diseases",totalDownloads:110,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Since the advent of the twentieth century, several severe virus outbreaks have occurred—H1N1 (1918), H2N2 (1957), H3N2 (1968), H1N1 (2009) and recently COVID-19 (2019)—all of which have posed serious challenges to public health. Therefore, rapid identification of efficacious antiviral medications is of ongoing paramount importance in combating such outbreaks. Due to the long cycle of drug development, not only in the development of a “safe” medication but also in mandated and extensive (pre)clinical trials before a drug can be safely licensed for use, it is difficult to access effective and safe novel antivirals. This is of particular importance in addressing infectious disease in appropriately short period of time to limit stress to ever more interlinked societal infrastructures; including interruptions to economic activity, supply routes as well as the immediate impact on health care. Screening approved drugs or drug candidates for antiviral activity to address emergent diseases (i.e. repurposing) provides an elegant and effective strategy to circumvent this problem. As such treatments (in the main) have already received approval for their use in humans, many of their limitations and contraindications are well known, although efficacy against new diseases must be shown in appropriate laboratory trials and clinical studies. A clear in this approach in the case of antivirals is the “relative” simplicity and a high degree of conservation of the molecular mechanisms that support viral replication—which improves the chances for a functional antiviral to inhibit replication in a related viral species. However, recent experiences have shown that while repurposing has the potential to identify such cases, great care must be taken to ensure a rigourous scientific underpinning for repurposing proposals. Here, we present a brief explanation of drug repurposing and its approaches, followed by an overview of recent viral outbreaks and associated drug development. We show how drug repurposing and combination approaches have been used in viral infectious diseases, highlighting successful cases. Special emphasis has been placed on the recent COVID-19 outbreak, and its molecular mechanisms and the role repurposing can/has play(ed) in the discovery of a treatment.",signatures:"Ran Zhang, Rick Oerlemans, Chao Wang, Lili Zhang and Matthew R. Groves",downloadPdfUrl:"/chapter/pdf-download/79867",previewPdfUrl:"/chapter/pdf-preview/79867",authors:[{id:"183178",title:"Dr.",name:"Matthew",surname:"Groves",slug:"matthew-groves",fullName:"Matthew Groves"},{id:"238482",title:"Mr.",name:"Chao",surname:"Wang",slug:"chao-wang",fullName:"Chao Wang"},{id:"423846",title:"Mr.",name:"Ran",surname:"Zhang",slug:"ran-zhang",fullName:"Ran Zhang"},{id:"423847",title:"Mr.",name:"Rick",surname:"Oerlemans",slug:"rick-oerlemans",fullName:"Rick Oerlemans"},{id:"437740",title:"MSc.",name:"Lili",surname:"Zhang",slug:"lili-zhang",fullName:"Lili Zhang"}],corrections:null},{id:"81126",title:"Antituberculosis Drug Repurposing: A New Hope for Tackling Multi-Challenging TB in Timely Manner",doi:"10.5772/intechopen.101642",slug:"antituberculosis-drug-repurposing-a-new-hope-for-tackling-multi-challenging-tb-in-timely-manner",totalDownloads:50,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Tuberculosis still stands as the world’s leading infectious disease as 1/4th of the world’s population harbors Latent TB infection (LTBI) > 10 million develops active TB and ~ 1.5 million people die per year. Approximately 4,65,000 people fell ill with multidrug or rifampicin-resistant tuberculosis (MDR/RR-TB)/year. This deadly TB scenario demands new TB drug regimens to tackle global infection reservoir, and worldwide spread of drug resistance and DS TB. Successful entry of single new drug into market is much complicated mission owing to time, cost, efficacy, and safety issues. Therefore, drug repurposing seems one reliable hope to meet the challenges of modern TB drug discovery timely, as it starts with examining market acclaimed drugs against other diseases for their efficacies against tuberculosis avoiding several lengthy and costly steps required for new molecules. Several drugs have been identified, which show potential for TB treatment. There is need for careful consideration of various trial designs to ensure that TB phase III trials are initiated for fruitful development of new TB treatment regimens. TB drug repurposing will not only give fast track novel drugs but will also serve to identify new targets for future development in cost-effective manner.",signatures:"Shahnawaz Majeed, Safiya Mehraj and Zahoor Ahmad",downloadPdfUrl:"/chapter/pdf-download/81126",previewPdfUrl:"/chapter/pdf-preview/81126",authors:[{id:"425596",title:"Associate Prof.",name:"Zahoor",surname:"Parry",slug:"zahoor-parry",fullName:"Zahoor Parry"},{id:"437258",title:"Dr.",name:"Shahnawaz",surname:"Majeed",slug:"shahnawaz-majeed",fullName:"Shahnawaz Majeed"},{id:"437442",title:"Ms.",name:"Safiya",surname:"Mehraj",slug:"safiya-mehraj",fullName:"Safiya Mehraj"}],corrections:null},{id:"79440",title:"Drug Repurposing for Tuberculosis",doi:"10.5772/intechopen.101393",slug:"drug-repurposing-for-tuberculosis",totalDownloads:150,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a major global health concern given the increase in multiple forms of drug-resistant TB. This underscores the importance of a continuous pipeline of new anti-TB agents. From recent studies, it is evident that the increase in drug efficacy is being achieved through re-engineering old TB-drug families and repurposing known drugs. This approach has led to producing a newer class of compounds which not only saves time and investment in developing newer drugs but is also effective in identifying drug candidates with novel mechanisms to treat multi-drug resistant strains. The repurposed drugs moxifloxacin, linezolid, and clofazimine are used to treat extensively drug-resistant TB when first- and/or second-line drugs fail. The chapter covers a detailed background on the current status of the repurposed drugs in the TB drug-discovery pipeline and discusses a potential way forward.",signatures:"Nicole C. Cardoso, Carel B. Oosthuizen, Nashied Peton and Vinayak Singh",downloadPdfUrl:"/chapter/pdf-download/79440",previewPdfUrl:"/chapter/pdf-preview/79440",authors:[{id:"423041",title:"Dr.",name:"Vinayak",surname:"Singh",slug:"vinayak-singh",fullName:"Vinayak Singh"},{id:"435887",title:"Dr.",name:"Nicole C.",surname:"Cardoso",slug:"nicole-c.-cardoso",fullName:"Nicole C. Cardoso"},{id:"435888",title:"Dr.",name:"Nashied",surname:"Peton",slug:"nashied-peton",fullName:"Nashied Peton"},{id:"435889",title:"Dr.",name:"Carel B.",surname:"Oosthuizen",slug:"carel-b.-oosthuizen",fullName:"Carel B. Oosthuizen"}],corrections:null},{id:"79784",title:"Breast Cancer Drug Repurposing a Tool for a Challenging Disease",doi:"10.5772/intechopen.101378",slug:"breast-cancer-drug-repurposing-a-tool-for-a-challenging-disease",totalDownloads:120,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Drug repurposing is one of the best strategy for drug discovery. There are several examples where drug repurposing has revolutionized the drug development process, such as metformin developed for diabetes and is now employed in polycystic ovarian syndrome. Drug repurposing against breast cancer is currently a hot topic to look upon. With the continued rise in breast cancer cases, there is a dire need for new therapies that can tackle it in a better way. There is a rise of resistance to current therapies, so drug repurposing might produce some lead candidates that may be promising to treat breast cancer. We will highlight the breast cancer molecular targets, currently available drugs, problems with current therapy, and some examples that might be promising to treat it.",signatures:"Jonaid Ahmad Malik, Rafia Jan, Sakeel Ahmed and Sirajudheen Anwar",downloadPdfUrl:"/chapter/pdf-download/79784",previewPdfUrl:"/chapter/pdf-preview/79784",authors:[{id:"426014",title:"Assistant Prof.",name:"Sirajudheen",surname:"Anwar",slug:"sirajudheen-anwar",fullName:"Sirajudheen Anwar"},{id:"439723",title:"Dr.",name:"Jonaid Ahmad",surname:"Malik",slug:"jonaid-ahmad-malik",fullName:"Jonaid Ahmad Malik"},{id:"439725",title:"Dr.",name:"Rafia",surname:"Jan",slug:"rafia-jan",fullName:"Rafia Jan"},{id:"439726",title:"Dr.",name:"Sakeel",surname:"Ahmed",slug:"sakeel-ahmed",fullName:"Sakeel Ahmed"}],corrections:null},{id:"78978",title:"The Future Perspectives of Drug Repurposing and Treatment for the Drug Resistant Breast Cancer: A Review",doi:"10.5772/intechopen.100143",slug:"the-future-perspectives-of-drug-repurposing-and-treatment-for-the-drug-resistant-breast-cancer-a-rev",totalDownloads:140,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Breast cancer is a major health concern as it is the second leading cause of death from cancer. There are several well-known risk factors that contribute to breast cancer. Despite the various treatment options available, complete cure is still difficult due to heterogenicity of BC subtypes. As a result, identifying BC subtypes is critical for determining the optimal treatment approach. Over the last several years, new drugs targeting particular therapeutic targets have resulted in significant advances in the treatment of breast cancer. Nonetheless, resistance to treatment is the “major” issue, and a significant increase in survival rates has been the main focus for researchers. The purpose of this review article is to provide a broad overview of the molecular basis of drug resistance in breast cancer, as well as a detailed assessment of current treatment options, potential new treatment methods for drug-resistant breast cancer and repurposed drugs used for treatment. The possibility of non-cancer drugs being studied for breast cancer in the future, as well as the obstacles and bottlenecks of drug repurposing, is also highlighted. Finally, we go through present problems and future prospects in drug-resistant breast cancer therapy.",signatures:"Panneerselvam Theivendren, Selvaraj Kunjiappan, Yashoda Mariappa Hegde, Kaveena Ravi, Sivakumar Vellaichamy, Murugananthan Gopal and Manimekalai Pichaivel",downloadPdfUrl:"/chapter/pdf-download/78978",previewPdfUrl:"/chapter/pdf-preview/78978",authors:[{id:"347086",title:"Prof.",name:"Panneerselvam",surname:"Theivendren",slug:"panneerselvam-theivendren",fullName:"Panneerselvam Theivendren"},{id:"347087",title:"Dr.",name:"Selvaraj",surname:"Kunjiappan",slug:"selvaraj-kunjiappan",fullName:"Selvaraj Kunjiappan"},{id:"417749",title:"Ms.",name:"Yashoda",surname:"Mariappa Hegde",slug:"yashoda-mariappa-hegde",fullName:"Yashoda Mariappa Hegde"},{id:"417750",title:"Dr.",name:"Murugananthan",surname:"Gopal",slug:"murugananthan-gopal",fullName:"Murugananthan Gopal"},{id:"417757",title:"Dr.",name:"Sivakumar",surname:"Vellaiswamy",slug:"sivakumar-vellaiswamy",fullName:"Sivakumar Vellaiswamy"},{id:"427413",title:"Dr.",name:"Manimekalai",surname:"Pichaivel",slug:"manimekalai-pichaivel",fullName:"Manimekalai Pichaivel"},{id:"428364",title:"Ms.",name:"Kaveena",surname:"Ravi",slug:"kaveena-ravi",fullName:"Kaveena Ravi"}],corrections:null},{id:"75111",title:"Repurposing of Metformin as a Multifaceted and Multitasking Preventative and Treatment for Cancer",doi:"10.5772/intechopen.96101",slug:"repurposing-of-metformin-as-a-multifaceted-and-multitasking-preventative-and-treatment-for-cancer",totalDownloads:297,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Metformin is a cornerstone treatment of diabetes mellitus. Since 2005 when it has been first reported to reduce the risk of cancer in diabetics, a large number of preclinical and clinical studies have implicated its potential role as a preventative and adjunct therapy for a broad range of cancers. Whereas preclinical studies demonstrate its actions on a multitude of molecular pathways involving nearly all aspects of cancer development including metabolism, angiogenesis, apoptosis, autophagy, immunity, epigenetics, inflammation and crosstalk with the microbiome, other studies demonstrate its synergism with a range of anticancer modalities including chemotherapy, radiotherapy, immunotherapy, and targeted therapies. Furthermore, an increasing number of clinical studies not only confirm its preventative properties against cancers but have extended its potential for a possible adjunctive role in the neoadjuvant, adjuvant, maintenance and salvage therapies of cancer. This article intends to summarize the basic science that allows us to understand the complex multiple mechanisms of action of this remarkable multitasking molecule as well as review the recent meta-analyses that have summarized the clinical studies assessing the therapeutic efficacy of metformin for various cancers.",signatures:"Raymond Chang",downloadPdfUrl:"/chapter/pdf-download/75111",previewPdfUrl:"/chapter/pdf-preview/75111",authors:[{id:"319123",title:"Dr.",name:"Raymond",surname:"Chang",slug:"raymond-chang",fullName:"Raymond Chang"}],corrections:null},{id:"78376",title:"Ivermectin: Potential Repurposing of a Versatile Antiparasitic as a Novel Anticancer",doi:"10.5772/intechopen.99813",slug:"ivermectin-potential-repurposing-of-a-versatile-antiparasitic-as-a-novel-anticancer",totalDownloads:348,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"Drug repositioning is a alternative strategy to discover and develop anticancer drugs based on identification of new mechanisms of actions and indications for existing compounds. Ivermectin belongs to the avermectin group of compounds, a series of 16-membered macrocyclic lactone moieties discovered in 1967 and FDA-approved for human use since 1987. Ivermectin has since been used by millions of people worldwide, and have demonstrated a wide margin of clinical safety. Here we summarize the in vitro and in vivo evidence demonstrating ivermectin\\'s potential as a multitargeting anticancer drug that exerts antitumor effects against different tumor types. Notably, the in vitro and in vivo antitumor activities of ivermectin are achieved at concentrations that can be clinically achieved based on human pharmacokinetic studies done in the clinical studies. Moreover, repurposed ivermectin safety has been well established recently in clinical studies against COVID-19. Consequently, we believe that ivermectin is an excellent potential candidate drug that can be repurposed for cancer and deserves rigorous evaluation against a variety of cancers in well-designed clinical trials.",signatures:"Alfonso Dueñas-González and Mandy Juárez-Rodríguez",downloadPdfUrl:"/chapter/pdf-download/78376",previewPdfUrl:"/chapter/pdf-preview/78376",authors:[{id:"421841",title:"Prof.",name:"Alfonso",surname:"Dueñas-González",slug:"alfonso-duenas-gonzalez",fullName:"Alfonso Dueñas-González"},{id:"421846",title:"Dr.",name:"Mandy",surname:"Juárez-Rodríguez",slug:"mandy-juarez-rodriguez",fullName:"Mandy Juárez-Rodríguez"}],corrections:null},{id:"73134",title:"Progesterone and Glucocorticoid Receptor Modulator Mifepristone (RU-486) as Treatment for Advanced Cancers",doi:"10.5772/intechopen.93545",slug:"progesterone-and-glucocorticoid-receptor-modulator-mifepristone-ru-486-as-treatment-for-advanced-can",totalDownloads:318,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The fetal placental unit has paternal proteins which would normally result in immune rejection of fetus. Thus, to allow growth to 266 days, the mother must develop immunosuppressive proteins, cytokines, etc. to allow progression to a full-term baby. One of these essential immunomodulatory proteins is called the progesterone induced blocking factor (PIBF). Probably, the mechanism involved allowing the progesterone receptor antagonist mifepristone to cause termination of a pregnancy is by blocking the PIBF protein. There is good evidence that cancerous tumors borrow some of the same mechanisms as the fetus to escape immune surveillance, including the PIBF protein. Research data suggest that this protein is made and excreted by embryonic cells, mesenchymal cells, and trophoblast cells of the fetal placental unit to block the killing effect of natural killer cells and T-cells in the fetal microenvironment. Cancer cells do the same. Indeed, there is good evidence that mifepristone, a drug approved for pregnancy termination, can significantly improve length and quality of life in patients with various advanced cancers.",signatures:"Jerome H. Check and Diane L. Check",downloadPdfUrl:"/chapter/pdf-download/73134",previewPdfUrl:"/chapter/pdf-preview/73134",authors:[{id:"138125",title:"Dr.",name:"Jerome H.",surname:"Check",slug:"jerome-h.-check",fullName:"Jerome H. Check"},{id:"327604",title:"Dr.",name:"Diane L.",surname:"Check",slug:"diane-l.-check",fullName:"Diane L. Check"}],corrections:null},{id:"78716",title:"Integrating Immunotherapy with Chemotherapy: A New Approach to Drug Repurposing",doi:"10.5772/intechopen.100183",slug:"integrating-immunotherapy-with-chemotherapy-a-new-approach-to-drug-repurposing",totalDownloads:130,totalCrossrefCites:5,totalDimensionsCites:8,hasAltmetrics:0,abstract:"Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking the three hormonal receptors namely estrogen receptor, progesterone receptor and HER2 receptor, and the only treatment option available for TNBC is chemotherapy. Chemotherapy lacks specificity since it acts on normal healthy cells as well resulting into secondary diseases in TNBC patients. In addition chemotherapy poses recurrence and relapse issues due to the development of chemoresistance among TNBC patients. Immunotherapy remarkably immune checkpoint inhibitors show a great therapeutic potential in TNBC. As TNBC contain an increased TILs (tumor infiltrating lymphocytes) infiltration making it more suitable as a therapeutic target anti-tumor immune strategy. Moreover, evidences have indicated that chemotherapy upregulates the anti-tumor immune response in TNBC. As a result, a combination of immunotherapy with chemotherapy may increase the overall relapse and recurrence free survival of TNBC patients. Therefore, in this chapter we will focus on how the immunotherapy works in TNBC, their effects and consequences. We will further be discussing the clinical studies and the importance of immune checkpoint inhibitors (ICIs) in combination with various therapeutic agents and target. Further, we will explore the processes involved.",signatures:"Hina Qayoom, Umar Mehraj, Shariqa Aisha, Shazia Sofi and Manzoor Ahmad Mir",downloadPdfUrl:"/chapter/pdf-download/78716",previewPdfUrl:"/chapter/pdf-preview/78716",authors:[{id:"277876",title:"Dr.",name:"Manzoor",surname:"Mir",slug:"manzoor-mir",fullName:"Manzoor Mir"},{id:"278592",title:"Mr.",name:"Umar",surname:"Mehraj",slug:"umar-mehraj",fullName:"Umar Mehraj"},{id:"424546",title:"Ms.",name:"Hina",surname:"Qayoom",slug:"hina-qayoom",fullName:"Hina Qayoom"},{id:"424547",title:"Mrs.",name:"Shariqa",surname:"Rasool",slug:"shariqa-rasool",fullName:"Shariqa Rasool"},{id:"473664",title:"Dr.",name:"Shazia",surname:"Sofi",slug:"shazia-sofi",fullName:"Shazia Sofi"}],corrections:null},{id:"80170",title:"Role of Activated Cdc42-Associated Kinase 1 (ACK1/TNK2)-Inhibitors in Precision Oncology",doi:"10.5772/intechopen.102343",slug:"role-of-activated-cdc42-associated-kinase-1-ack1-tnk2-inhibitors-in-precision-oncology",totalDownloads:69,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Activated Cdc42-associated kinase 1 (ACK1) is an intracellular non-receptor tyrosine kinase referred to as TNK2, which is considered as an oncogene and therapeutic target in various cancers including breast cancer, non-small-cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), and many others. Oncogenic non-receptor tyrosine kinase mutations occur either due to point mutations, duplications or insertions and deletions, or by involving in the development of a fusion gene resulting from a chromosomal rearrangement. ACK1 is involved with multiple signaling pathways of tumor progression. With these signaling networks, ACK1 participates in cell survival, invasion, migration, and tumorigenesis that are strongly related to the prognosis and clinicopathology of cancers. Previous studies predicted that ACK1 is a carcinogenic factor and blockage of ACK1 inhibits cancer cell survival, proliferation, migration, and radiation resistance. FDA has approved many multi-kinase inhibitors as therapeutic drugs that show good inhibitory activity not against ACK1 but also towards multiple targets. As ACK1 is a key target for other neurological diseases, inflammation, and immunological diseases also, so the studies on these inhibitors not only provide potential strategies for the treatment of cancers that require simultaneous targeting of multiple targets but also can be used in drug repurposing for other diseases.",signatures:"Ruby Srivastava",downloadPdfUrl:"/chapter/pdf-download/80170",previewPdfUrl:"/chapter/pdf-preview/80170",authors:[{id:"185788",title:"Dr.",name:"Ruby",surname:"Srivastava",slug:"ruby-srivastava",fullName:"Ruby Srivastava"}],corrections:null},{id:"79414",title:"Gene Signature-Based Drug Repositioning",doi:"10.5772/intechopen.101377",slug:"gene-signature-based-drug-repositioning",totalDownloads:174,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"With the advent of dynamical omics technology, especially the transcriptome and proteome, a huge amount of data related to various diseases and approved drugs are available under multi global projects or researches with their interests. These omics data and new machine learning technology largely promote the translation of drug research into clinical trials. We will cover the following topics in this chapter. 1) An introduction to the basic discipline of gene signature-based drug repurposing; 2) databases of genes, drugs and diseases; 3) gene signature databases of the approved drugs; 4) gene signature databases of various diseases; 5) gene signature-based methods and tools for drug repositioning; 6) new omics technology for drug repositioning; 7) drug repositioning examples with reproducible code. And finally, discuss the future trends and conclude.",signatures:"Zhilong Jia, Xinyu Song, Jinlong Shi, Weidong Wang and Kunlun He",downloadPdfUrl:"/chapter/pdf-download/79414",previewPdfUrl:"/chapter/pdf-preview/79414",authors:[{id:"423125",title:"Assistant Prof.",name:"Zhilong",surname:"Jia",slug:"zhilong-jia",fullName:"Zhilong Jia"},{id:"435869",title:"MSc.",name:"Xinyu",surname:"Song",slug:"xinyu-song",fullName:"Xinyu Song"},{id:"435870",title:"Prof.",name:"Jinlong",surname:"Shi",slug:"jinlong-shi",fullName:"Jinlong Shi"},{id:"435872",title:"Prof.",name:"Weidong",surname:"Wang",slug:"weidong-wang",fullName:"Weidong Wang"},{id:"435873",title:"Prof.",name:"Kunlun",surname:"He",slug:"kunlun-he",fullName:"Kunlun He"}],corrections:null},{id:"80532",title:"Recent Progress in Drug Repurposing Using Protein Variants and Amino Acids in Disease Phenotypes/Disorders",doi:"10.5772/intechopen.102571",slug:"recent-progress-in-drug-repurposing-using-protein-variants-and-amino-acids-in-disease-phenotypes-dis",totalDownloads:58,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Life is constituted of large group of macromolecule, functional and structural called “Protein,” made of amino acids (AA), and linked with peptide bonds with specific protein unique sequences. Variations in proteins are thought to have diverse effects with consequences on structure, stability, interactions, pH, enzymatic activity, abundance and other properties. Variants can be of genetic origin or it could occur de novo at the post-translational protein level. The sequence of amino acids defines protein structure and functions. Protein is involved in several critical functions like the physical cell-cell communication. Breakthrough in molecular science has shown that, to develop drugs for managing a disease-associated variations requires understanding of consequences of variants on the function of the affected protein and the impact on the pathways, in which protein is involved. Using biophysical/bioinformatics methods, immense amount of variation data generated is handled-connected to disease phenotypes. Obviously, there remain continuous needs for the combinations of genetic probing methods/bioinformatics, to predict single-nucleotide variations (SNV), for effective rational drug design that would embrace naturally occurring bioactive components of plant origin, towards the effective management of disease phenotype emanating from protein and amino acid variations. This, well thought out and synchronized concept, remains a way forward.",signatures:"Michael P. Okoh and Lukman A. Alli",downloadPdfUrl:"/chapter/pdf-download/80532",previewPdfUrl:"/chapter/pdf-preview/80532",authors:[{id:"422134",title:"Prof.",name:"Michael P.",surname:"Okoh",slug:"michael-p.-okoh",fullName:"Michael P. Okoh"},{id:"422873",title:"Prof.",name:"Lukman A.",surname:"Alli",slug:"lukman-a.-alli",fullName:"Lukman A. Alli"}],corrections:null},{id:"79461",title:"Repurposing Market Drugs to Target Epigenetic Enzymes in Human Diseases",doi:"10.5772/intechopen.101397",slug:"repurposing-market-drugs-to-target-epigenetic-enzymes-in-human-diseases",totalDownloads:95,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Drug discovery is an exciting yet highly costly endeavor. In the United States, developing a new prescription medicine that gains marketing approval takes near a decade and costs drugmakers for near 3 billion. More challengingly, the success rate of a compound entering phase I trials is just slightly under 10%. Because of these mounting hurdles, repurposing market approved drugs to new clinical indications has been a new trend on the rise. Another merit to this approach is the already confirmed toxicity profiles of the drugs and their possession of drug-like features. Thus, repurposed drugs can reach the market approved stage in a much faster, cheaper, and more efficient way. Notably, epigenetic enzymes play a critical role in the etiology and progression of different diseases. Researchers are now assessing the possibilities of using market approved drugs to target epigenetic enzymes as a novel strategy to curtail disease progression. Thus, in this book chapter, we will provide an outlook on repurposing market drugs to target epigenetic enzymes in various diseases. Consequently, this book chapter will not only provide the readers with current knowledge in this specific field, but also will shed light on the pathway forward for repurposing market drugs to target epigenetic enzymes in human diseases.",signatures:"Aishat Motolani, Matthew Martin, Steven Sun and Tao Lu",downloadPdfUrl:"/chapter/pdf-download/79461",previewPdfUrl:"/chapter/pdf-preview/79461",authors:[{id:"218030",title:"Dr.",name:"Tao",surname:"Lu",slug:"tao-lu",fullName:"Tao Lu"},{id:"256979",title:"Mr.",name:"Matthew",surname:"Martin",slug:"matthew-martin",fullName:"Matthew Martin"},{id:"323670",title:"Ms.",name:"Aishat A.",surname:"Motolani",slug:"aishat-a.-motolani",fullName:"Aishat A. Motolani"},{id:"424907",title:"Mr.",name:"Steven",surname:"Sun",slug:"steven-sun",fullName:"Steven Sun"}],corrections:null},{id:"81382",title:"Therapeutic Inhibitors: Natural Product Options through Computer-Aided Drug Design",doi:"10.5772/intechopen.104412",slug:"therapeutic-inhibitors-natural-product-options-through-computer-aided-drug-design",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Drug repurposing involves reusing an active pharmaceutical ingredient that is already in the market and drugs that were unsuccessful in their clinical phases of development for a new indication. It has numerous benefits in drug development. Therapeutic inhibitors are agents that could be of synthetic or natural source with the ability to trigger the down-regulation of an enzyme or protein, thereby inducing therapeutic effect(s). Researchers have embraced synthetic methods in searching for therapeutic molecules through structural activity relationships and other means in the past and recent times. Despite these synthetic drugs, the morbidity and mortality rate of ailment and disease affecting humanity remains overwhelming. Research has shown that solutions to these challenges can be attempted through drug repurposing. In the past, natural products in raw forms have been utilized in traditional, complementary medicine to manage and treat diseases and illnesses, as there are molecules in use today as drugs, which originated from plants and other natural sources. Studies on natural products have led to diverse natural product databases that can serve as a source of repurposing agents. There are also databases for protein and enzymes of human origin, which have an enormous role in the in-silico drug repurposing approach.",signatures:"InnocentMary IfedibaluChukwu Ejiofor, Christabel Chikodili Ekeomodi, Sharon Elomeme and MaryGeraldine Ebele Ejiofor",downloadPdfUrl:"/chapter/pdf-download/81382",previewPdfUrl:"/chapter/pdf-preview/81382",authors:[{id:"340474",title:"Dr.",name:"InnocentMary IfedibaluChukwu",surname:"Ejiofor",slug:"innocentmary-ifedibaluchukwu-ejiofor",fullName:"InnocentMary IfedibaluChukwu Ejiofor"},{id:"445202",title:"Ms.",name:"Christabel Chikodili",surname:"Ekeomodi",slug:"christabel-chikodili-ekeomodi",fullName:"Christabel Chikodili Ekeomodi"},{id:"446421",title:"Ms.",name:"Sharon",surname:"Elomeme",slug:"sharon-elomeme",fullName:"Sharon Elomeme"},{id:"452523",title:"Mrs.",name:"MaryGeraldine Ebele",surname:"Ejiofor",slug:"marygeraldine-ebele-ejiofor",fullName:"MaryGeraldine Ebele Ejiofor"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"3311",title:"Current Perspectives in HIV Infection",subtitle:null,isOpenForSubmission:!1,hash:"1bcacf84d50370cac414fea1616244c6",slug:"current-perspectives-in-hiv-infection",bookSignature:"Shailendra K. 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According to [1], cloud computing is a paradigm for enabling universal, easy-to-use, on-demand network access to a shared pool of configurable computing resources such as networks, storage, servers, applications, and services, which can be quickly provided and released with very little management effort. Cloud service portability can be well-defined as the capacity to move cloud services from one provider to another in an easy manner. Cloud computing can also be described as “a large scale distributed computing model motivated by frugalities of scale in which a pool of abstracted, virtualized, dynamically scalable managed storage, computing power, services, and platforms are distributed on demand to external customers over the Internet” [2]. Important features of cloud computing are scalability, on-demand service, and virtualization. The virtualized resources are provided through an Application Programming Interface (API) [3]. Cloud computing offers three major services, namely, Software-as-a-Service (SaaS), Platform-as-a-Service (PaaS) and Infrastructure-as-a-Service (IaaS). Cloud deployment types are public, private, community, and hybrid clouds. Enterprises through cloud computing are able to focus on core activities and training instead of spending time and money on infrastructure.
Procurement of infrastructure is reduced or eliminated; it also implies little or no maintenance cost on infrastructure. On-demand benefit of the cloud ensures that enterprises utilize what they need per time, using state of the art technology. Importantly, only a resource utilized is paid for. In SaaS, a software that is owned, delivered, and managed remotely by one or more cloud service providers is offered on a pay-per-use manner [3]. SaaS usually is the most noticeable layer of cloud computing for cloud users. This is because it is majorly about actual software applications that are used and accessed on the cloud. IaaS refers to computing services like processing or storage that can be gotten as a service. The process of virtualization is the primary means of providing IaaS services. The PaaS referred to an abstraction layer between the IaaS and SaaS. PaaS is concerned with software development. Users develop their applications based on a platform and upload the code to the platform provided by the CSP. The user does not need to worry about infrastructure and the CSP manages the scaling of the applications. Applications deployed on the cloud including data are difficult to move between clouds, leading to portability issues. Vendor lock-in occurs when a cloud user cannot move data and application from a particular cloud service provider [4]. The lock-in could be termed vertical or horizontal heterogeneity [5]. Vertical heterogeneity occurs with IaaS that provides infrastructure to consumers. PaaS allows development and deployment of user’s applications. Such a platform uses specialized libraries and routines and moving application to another platform will require extensive changes [5]. In view of this, cloud users are forced to remain with a particular CSP and porting becomes very expensive [5]. Portability will therefore mean that cloud users will write codes that work in different clouds irrespective of the nature of the clouds. However, this should not be strictly so. Consumers should be able to change CSPs and move to any CSP that offers a better service at possibly a lower cost. Unfortunately, different cloud application platform offerings are categorized by considerable heterogeneity [6]. In view of these irreconcilabilities, users who deploy an application to a specific platform may find it difficult moving such an application to another CSP.
The focus of this chapter is to scrutinize data and application portability in cloud computing. The issues involved in application portability are discussed. Current industry trends are also be examined. This chapter contributes to enhancing developments in the area of cloud application portability. The rest of the chapter is structured as follows: Section 2 examines related work. Section 3 discusses issues related to cloud portability. Section 4 highlights the current development in cloud portability with reference to developments in the industry. Section 5 concludes the chapter and suggests the future area of research.
In [5], cloud application portability: an initial view is presented. The focus is on examining the heterogeneous nature of cloud platforms. Approaches to tackling the identified challenges were proposed through a cross-platform application process. In [4], the need for portability and interoperability in cloud computing is proposed. The approach is an open source model for enhancing portability and interoperability in the various cloud platforms. This will eventually reduce the cost of cloud migration. In [7], semantics-centric solutions for application and data portability in cloud computing is presented. The focus is on the problem of data and application portability in the cloud. The semantic web community proposed some solutions to overcome some aspects of cloud portability. In [6], portable cloud services using Topology and Orchestration Specification for Cloud Applications (TOSCA) is proposed. The focus is on the possibility of moving services between cloud providers to avoid vendor lock-in. This was done at the managerial and operational level using TOSCA. In [8], a portable cloud application—from theory to practice—is presented. The approach was to design an open source application capable of handling multiple cloud usage. This helps to deal with the issues of application, data, and service portability on the cloud.
In [9], a comparative analysis of legislation on how to attribute the right to data portability in Europe is presented. It discussed how competition is prevented by cloud service providers through lock-in. Thereafter, it examines legislation that makes portability possible for cloud consumers. In [10], a new cloud services portability platform is proposed. The approach is to design a cloud portability framework using an adapter model. This approach leverages on TOSCA for application portability. In [11], application mobility in pervasive computing: a survey is presented. The focus is to examine different migration methods for application portability. A framework was proposed along four dimensions to allow easy mobility of applications. In [12], challenges emerging from future cloud application scenarios are presented. Various aspects of cloud computing were examined. The issues of integration and interoperability were also discussed and suggestions made on the way forward. In [13], enabling portability in advanced information-centric services over structured peer-to-peer systems is proposed. The approach is a three-layer architecture to enhance portability. The middleware in the framework is versatile over a wide variety of applications. In [14], streamlining DevOps automation for cloud application using TOSCA as standardized metamodel is presented. The chapter proposes a framework for integrating different applications on the cloud. The framework is also implemented and validated. In [15], toward application portability in platform as a service is presented. The approach was to discuss portability options in terms of PaaS provider and the ecosystem capabilities. The proposed model was implemented with a data set and different PaaS vendors.
“Application portability is the capability of program to be implemented on numerous types of data processing systems without changing the program to a dissimilar language and with little or no modification” [4]. Portability is the capacity to use mechanisms or system lying on several software or hardware environments [8]. The primary focus of portability is in the PaaS. PaaS is divided into three layers namely, infrastructure, platform, and management. Since PaaS hides most of its physical properties, users are left with concepts like dynos, workers’ units, gears, or app cells that can be used for specific instances in PaaS, while CPU and disk utilization are negligible [4]. The CPU usage is the main factor for billing in IaaS, but instances count and RAM size are used in PaaS. Geographical location of application deployment is another issue. Based on latency considerations, applications are also subject to regional regulations [4]. The platform constitutes the hosting environment with two stack components: the runtime stack and service stack [4].
The runtime stack in PaaS constitutes the programming language used for developing the application such as Ruby on Rails which is fairly popular [4]. Higher stack leads to the more specificity in the application dependency; hence increasing lock-in risk. The service stack is divided into add-one and native and add–on services. The latter services, which are native services, are hosted by PaaS vendors, and it includes latency and performance services like data store [4]. While Add-on service is provided by third parties: they include data store and services like analytics, search engines, and messaging services. Another aspect is extensibility involving build packs that enable developments add own packages of service. The management layers allow control of the deployed application which encompasses pushing, starting and stopping an application, including the provision of native and add-on services. Importantly, resource usage and monitoring necessary for billings and scaling decision is carried out at the management layer. Even though the mentioned functionalities are collectively used by all various PaaS to a large extent, commands and procedures are not standardized and vary broadly between providers [4].
Cloud portability guarantees that applications, data, or services work in the same way in different cloud services with a common programmable interaction [8]. A primary reason for portability is migrating all or part of existing services between clouds. This could be because of the need for optimal utilization, to reduce cost, technology, or SLA issues. Most challenging are situations in which a user’s cloud application is distributed between two or more providers and administrative domain simultaneously [9]. Portability can be categorized into three ways: functional portability, data portability, and service enhancement. Functional portability is realized by describing the application’s functionality details in a vendor–agnostic manner [8]. Device agnosticism allows hardware and software components to work with various systems without requiring any special adaptations. Hence, there is compatibility across most common systems. Data portability is reached when a customer is able to access and salvage application data from one provider and to input this into a corresponding application hosted by another provider. Service enhancements metadata is added through annotation [8]. The metadata provides information about other data. Also, control APIs permit infrastructure to be added and reconfigured instantaneously, based on traffic and other factors [9]. The requirement for portability at PaaS focuses on lessening the amount of rewriting when application is ported. Data portability permits users to transfer their personal information from one service to another, choosing a service suitable to their needs [10]. Another advantage of porting is that it allows a user to be released from lock-in to a provider. Ironically, data portability is also in the interest of the CSP. This is because when users are allowed to freely move data, trust will be enhanced between CSPs and users. In addition, more information can be used by CSPs in the area of advertising.
There are four areas of concern in application portability, namely programming language and framework, platform-specific services, data store, and platform-specific configuration files [11]. The specific programming language that is used to build an application is a major determining factor in cross-platform deployment. All cloud platforms have certain languages and framework which they support. For instance, Google AppEngine makes available support to Java, but does not extend such support to Java class libraries which are supported by OpenShift [11]. Cloud platform provides services through specific APIs. A service is a high–level functionality that the provider can use with no need for from-scratch implementation [6]. Analytical tools that are used in data sets and APIs for image manipulation are examples in this area. Reduction of application development time can be achieved when developers use such platform services. Developers can join in functionalities from platform services by binding it to the respective platform APIs instead of programming those functionalities from scratch [8].
Two types of data storage exist on the cloud platform. These are: data base store and file store. Data base store is for strong structured data, while file store is like a hard disk on the cloud. There are two kinds of data base store: SQL and NoSQL. The SQL database is the traditional relational database available on all major cloud providers. The NoSQL is a new system that groups all database systems that do not adhere to the SQL relational structure. NoSQL has simple operations, faster access, and the ability to distribute data over many services among other characteristics [6].
Configuration files are used by traditional software applications to instruct the environment on how to execute on the application. Platform-specific configuration files also exist on the cloud. Google AppEngine, for instance, uses the “app engine – web xml” file. Adapting the configuration file to each target cloud platform affects application portability [8]. Solution to cloud portability issues are through standardization and intermediation. Standardization indicates the definition of common set of standards for PaaS offerings. The adaption of such standards by all CSPs will enable developers design, deploy, and manage their applications independent of a cloud platform.
The Distributed Management Task Force (DMTF) evolved the open virtualization format (OVF) that enables standardization of virtual machines’ formats and portability. The Storage Network Industry Associations (SNIA) evolved the Cloud Data Management Interface (CDMI) to standardize the issue of cloud storage services [5]. The Topology and Orchestration Specification for Cloud Applications (TOSCA) is supported by Organization for the Advancement of Structured Information Standards (OASIS) for standardizing applications to enable portability across platforms [5]. Intermediation frees application development from platform-specific APIs and supported formats. jCloud and mOSAIC are open source platforms meant to resolve portability issues based on platform-specific APIs [5]. The issue of data storage is also being addressed by the Bridge Query Language (BQL).
As already discussed, several organizations have emerged to deal with the issue of portability. To move workloads between clouds, there is a need for standardized programming interfaces, layers of abstraction, and management capabilities [4]. Making programming interfaces standard allows movement of programs between interfaces. These standards allow companies to leverage on toolsets when preparing IT tasks for deployment on a cloud service [4]. Portability between cloud resources is also made more feasible by insulation of cloud services from underlying infrastructure through layer of abstraction. Layer of abstraction also increases speed of switching cloud services as well as decreases the cost and stress of such activity because of a reduction in the dependency on underlying infrastructure like processors, operating system and virtualization software [4]. Management capability is necessary to enable IT personnel handle the cloud services to which they subscribe without the introduction of new layers of capability. For success, these management capabilities must work well with already existing management products, both for managing virtual and physical services.
Multiple hypervisor technology such as VMware, Hyper-V, KVM Ven should be supported appropriately [4]. The virtual machine has become an essential unit of work and encapsulation especially for IaaS and some PaaS clouds [4]. Support for multiple hypervisor technology should enable customers choose their preferred VM and quickly transfer to it irrespective of the underlying platform. This is because there is likely to be mixed virtualization environment in the enterprise of a customer.
The coming of application virtualization continues to break the ties between the operating system and the application but a large number of applications are still dependent on specific versions of an operating system [4]. Enterprises have built several types of operating systems in their data centers overtime; which implies that it is impossible to limit users of the cloud to only a particular type of OS (Operating System) and enterprises would not be able to attend to large number of workloads.
Data centers were chosen by most enterprises a long time ago and some of these programming models may not be right for the cloud. IT staff could also show reluctance to change these programming models because of their familiarity with them [4]. Cloud providers must utilize current programming models such as. Net and Java, and web models like PHP and Ruby. When clouds do not support these languages, more importance is placed on hybrid cloud management.
PaaS cloud is simply programming to a given cloud platform. PaaS has a lot of functionalities such as massive scalability. On the other hand, APIs are useful only to new applications. There is a need for the modification of existing applications to benefit from these APIs. This modification is usually difficult and expensive procedure [4]. In effect, customers must examine the complete API set in such a way as to be able to migrate and also move out later if the need arises. Although cloud service providers are excited about migrating customers to their platform and usually provide tools for this purpose, it is sometimes difficult for customers to move their applications from cloud to cloud [4].
Dedicated management console is a vital part of every cloud technology including public clouds. This management must aim for more unification. This is especially because of the need for tighter coordination between on-premises and off-premises resources in a hybrid cloud [4]. API and management data accessibility would allow unified cloud console to support access control, scheduling, resource management, and billing.
The data on application must also be portable, not just in terms of copying files from one location to another. Data can exist in the form of database or file with varying access methods. Data portability means application would be able to access and move production data which they need to operate upon [4]. Enterprise data requires appropriate standards for the support of data export and conversion from one format to another.
Software licensing has always been bound to location and hardware, and this has not changed with cloud computing. Customers must know of the restriction that software license has on cloud portability [4].
TOSCA defines composite applications and how they are managed using modules and for portability [6]. It characterizes the service template that contains a cloud service topology and its operations. For example, it defines an application hosted on an server which is hosted on an operating system, and method of deployment, method of termination, and management of the services provided [6]. Typically, managing services requires a lot of manual effort by the customer. Each enterprise learns how to operate an application, acquires management knowledge, and automates certain aspects in the scripts. TOSCA solves this challenge by enabling application development and operators to model management best practice and reoccurring tasks into clear plans [6]. With these plans being por between different environments and providers, reusability and automation of service management is achieved and this reduces the total ownership cost by a significant percentage. Automated service management will also enhance rapid elasticity and self-service. TOSCA plan is portable specifically because of its workflow language and engines it uses [6]. Example of workflow languages portable between dissimilar engines are Business Process Model and Notation (BPMN) and Business Process Expression Language (BPEL).
Cloud portability is a topic with huge importance to cloud computing. This section analyses some of the most recent research papers based on some core areas namely virtualization issues, data portability, application/application portability issues, API issues, security concerns, identity management/access control, and interoperability issues. Table 1 shows the comparative analysis of the core areas in cloud portability. From the analysis of the reviewed papers, application portability issues is seen to be the most discussed as it is mentioned in all reviewed papers except [16]. In contrast to application portability, only 33% of the reviewed papers specifically dealt with data portability issues. This is because application portability is more significant that data portability. Next highly mentioned with 87% among the reviewed papers are interoperability issues. These are because cloud portability and interoperability issues usually go hand in hand. Only [17, 18, 19, 20] did not discuss interoperability issues. Virtualization and API-specific issues were averagely discussed with 53% each. However only [16, 18, 21, 22, 23, 24, 25], that is, 40% of the reviewed papers, addressed security concerns. The lowest researched area from recently reviewed papers is identity management/access control issues which was only mentioned in [22]. It shows its minimal significance in cloud portability.
References | Virtualization issue | Data issues | Applications issues | API issues | Identity management and access control | Security concerns | Interoperability |
---|---|---|---|---|---|---|---|
[17] | |||||||
[18] | |||||||
[21] | |||||||
[26] | |||||||
[27] | |||||||
[28] | |||||||
[22] | |||||||
[23] | |||||||
[19] | |||||||
[24] | |||||||
[29] | |||||||
[30] | |||||||
[16] | |||||||
[31] | |||||||
[20] |
Comparative analysis of cloud portability issues.
Based on the analysis, most of the mentioned core areas were researched based on their perceived significance. However, the suggestion is for more focused research on security concerns in cloud portability-related researches. It is also noted that more research can be carried out to address virtualization and API issues. Identity management/access control issues in cloud portability can be of importance going forward and needs to be focused on a little more.
Cloud computing and application portability are vital issues in the cloud. Users are exposed to lock-in because of the inherent challenges of data and application portability. This is usually more pronounced in PaaS cloud, especially in terms of infrastructure and platform. Portability issues in term of APIs, storage, programming languages, and configuration files were discussed. There are organizations creating solutions to allow for standardization and intermediation in cloud portability. Suggestion from the industry was also examined and TOSCA (meant for application portability) was briefly discussed. In view of its relevance to cloud portability, discussions on virtualization and API-specific issues must continue to evolve.
We acknowledge the support and sponsorship provided by Covenant University through the Centre for Research, Innovation, and Discovery (CUCRID).
Since the early 19th century, indentation technique has been extensively used for characterizing the mechanical properties of vast range of materials. In general, the indentation test is known to measure the
In nanoindentation, the associated high-resolution depth sensing technique aids to estimate the depth or size of the deformation zone. The process records the continuous response of indentation load (
One of the breakthroughs is the capability of this technique in generating the
Considering this, the present chapter is dedicated to provide a reasonable understanding for generating
It is noteworthy that both the uni-axial tensile/compression test as well as the indentation technique are capable to assess the stress–strain characteristics of a material, however, with usually different size-scale of samples along with varying stress-states. The former provides an understanding for the degree of bond stretching induced elastic deformation and dislocation mediated plastic/permanent deformation in the material. To obtain such desired information, the strain-induced into the material should be controlled in such a way that, the material’s response reflects the gradual activation and transition from the elastic to the plastic deformation. This is realized in uni-axial deformation without any strain gradient in the specimen, at least macroscopically.
In contrary to that, upon indentation, presence multi-axial state of stress exists beneath the indenter tip. Moreover, the constraint nature of deformation induces strain gradient within the deformation volume. Hence, for assessing the elastic–plastic activity within the deformation zone, the indentation tests need to be specially designed to produce a smooth strain distribution (or gradient) along with its gradual increment. To maintain that, indenter tip geometry needs to be carefully chosen to reflect the
Before getting into the details about the configuration of the spherical indenter tip and its importance for
The most commonly used sharp pyramidal indenter such as four-sided Vickers (for micro-and macro-indentation) and three-sided Berkovich indenters (for nanoindentation) comes under the category of
Schematic illustration of the indentation behavior associated with traditional elastic-plastic metallic using (a-c) sharp geometrically similar indenter and (d-e) spherical non-geometrically similar indenter at various indentation depths.
On the other hand, a completely different deformation response is being experienced, while the specimen surface is indented using
Nevertheless, the most crucial part in this regard is the data analysis procedure that is necessary to convert the indentation
The concept for the generation of
Nevertheless, Tabor’s approach revealed the potential of the indentation technique and instigated more studies to develop a state-of-the-art protocol for generating
The Field and Swan approach has much significance in the present scenario, owing to its implementation of the Hertzian contact mechanics theory. Nevertheless, interpretation of indentation strain as per both Tabor’s as well as Field and Swan approaches has been questioned for its integrity with the fundamental concept of strain. In general, strain is defined as the ratio of change in length to the initial length in a region of deformation considered. However, this fundamental relationship is not met in both these above-mentioned approaches.
In order to overcome this fundamental lacking, various studies have been conducted to formulate an adequate relationship for the
Contact mechanics theory introduced by Hertz has provided a fundamental basis for the indentation technique [20]. Classical Hertzian theory predicts the elastic responses of frictionless contact between two different bodies of dissimilar geometries (with varying properties) in contact. This theory is formulated based on the assumption that material is homogenous and isotropic. In the present scenario of indentation using spherical indenter, the Hertzian theory for elastic contact between the sphere (indenter) and elastic half-space (specimen surface) is used for the formulation of
As explained in previous Section 2 (see Figure 1
Schematic representation of indentation of behavior of material in (a) fully elastic condition and in the pressure of (b) plastic deformation. Corresponding indentation load vs. indentation depth responses of materials are shown in (c) and (d).
Here
All these relations derived by Hertz has laid the foundation for the formulation
It is well understood from Section 3 that Tabor’s and Field and Swan’s protocols do not suffice to define the
As per this novel approach, eq. (1) is rearranged by incorporating the following relations:
The indentation strain defined using the above relationship satisfies the general definition of strain. This can be better appreciated from Figure 3(a). In the figure, the dashed spherical shaped region beneath the indenter tip schematically shows the actual size of the deformation zone upon indentation. Based on the
(a) Schematic representation of the deformation behaviour associated with indentation. Figure highlights the actual deformation zone of indentation and the idealized deformation zone of indentation. (b) Schematic representation of surface irregularities on a sample.
Furthermore, this novel protocol has provided a reasonable basis for the analogical comparison of indentation behavior using spherical indenter and uniaxial compression test. The overall nature of the material response upon nanoindentation can be considered as the replication of compressing up to a depth of
As mentioned in Section 1, nanoindentation typically generates a
The existence of an artefacts such as scratches or the presence of foreign particles on the surface can influence the
To avoid such issues, well-polished, smooth, flat and plane-parallel specimen should be subjected to nanoindentation. The necessary steps to achieve such artefact free surface vary with the material of interest. However, colloidal silica polish for few hours (minimum 3 h) after the conventional polish using silicon carbide paper with decreasing mesh size and diamond polish is prescribed for metallic specimens, to attain a reasonably good surface condition for the
It is noted that theoretical predictions and the experimental outcome may result to some disparities in case of the nanoindentation test. In this regard, it is noteworthy that proper data analysis plays a key role in the generation of
In
Indentation load vs. indentation depth response generated using nanoindentation. Insets in the figure highlight the method of indentation in CSM mode and N-CSM mode.
In the present scenario, the continuously varying
Here
In
In the above relationship, the
The above-mentioned data correction procedures for nanoindenter with
As explained in Section 5, the Hertzian relation has provided a basis to obtain
Prior to going through further details, the physical significance of
Schematic representation of the nature of deformation volume beneath the indenter tip for materials with three different degree of elastic-plastic property. Green line shows the sample with full depth recovery. The orange and light blue colors reveal the indentation behaviour of samples with different shares of elastic and plastic activities.
But, once the dislocation mediated plastic activity is instigated,
All these physical changes are also related to
Estimation of
The analytical significance of this mathematical derivation lies in the fact that unlike Tabor’s approach, this expression (eq. (7)) enables to assess the nature of deformation inside the material without a visual inspection of residual impression.
In the data analysis, once the evolving values of
(a)
As compared to the
here
Previous sections have elaborated the potential of the nanoindentation technique in appreciating the
It is noteworthy at this point that as compared to the traditional elastic–plastic metallic alloys, pseudoelastic system is different owing to the occurrence of reversible stress-induced martensitic transformation (
For optimizing the indentation parameters, a detailed analysis is performed on the
Optimization of indentation parameters is performed based on the close scrutiny of the experimentally generated
(a) The P-h response of pseudoelastic NiTi system at its optimized nanoindentation parameter condition (
Considering the extremely high depth recoverability (≥ 90%) of pseudoelastic NiTi system, following assumption is used while generating the corresponding
Section 6.3 has already mentioned about the validity of this assumption when material shows full depth recovery. In the present scenario, same assumption is used with depth recovery limit of 90% of the
Prior to conversation of
The present chapter elucidates the vast potential of nanoindentation technique to develop insights about the localized stress–strain characteristics of materials. Nevertheless, to achieve the
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\\n"}]'},components:[{type:"htmlEditorComponent",content:'Copyright is the term used to describe the rights related to the publication and distribution of original Works. Most importantly from a publisher's perspective, copyright governs how Authors, publishers and the general public can use, publish, and distribute publications.
\n\nIntechOpen only publishes manuscripts for which it has publishing rights. This is governed by a publication agreement between the Author and IntechOpen. This agreement is accepted by the Author when the manuscript is submitted and deals with both the rights of the publisher and Author, as well as any obligations concerning a particular manuscript. However, in accepting this agreement, Authors continue to retain significant rights to use and share their publications.
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\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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This chapter exclusively summarizes the properties of biochar, its interaction with soil microflora, and its role in plant growth promotion when added to the soil.",book:{id:"7305",slug:"biochar-an-imperative-amendment-for-soil-and-the-environment",title:"Biochar",fullTitle:"Biochar - An Imperative Amendment for Soil and the Environment"},signatures:"Jyoti Rawat, Jyoti Saxena and Pankaj Sanwal",authors:null},{id:"67917",title:"Organic Fertilizer Production and Application in Vietnam",slug:"organic-fertilizer-production-and-application-in-vietnam",totalDownloads:1275,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Crop production is an important subsector of Vietnam’s agriculture, has an impressive achievement in last 30 years and based on the intensive production with increasing use of chemical fertilizer and pesticide. Consequences are the negative effects on environment and human health and food safety. Organic agriculture has become a trend worldwide and is developing rapidly in the world. In Vietnam the certified organic farming area has expanded since 2012. Organic market revenue in Vietnam is estimated to be at $132.15 million a year. Most Vietnamese certified organic products are exported to international markets. Organic agriculture using organic fertilizer is one of Vietnam government’s priorities. Vietnam already produced organic fertilizer from different materials by using different production technologies, but the production capacity is small and does not meet the demand for organic agriculture. Vietnam government encourages, promotes the organic fertilizer production, application and has the policy to develop the organic fertilizer in Vietnam.",book:{id:"8017",slug:"organic-fertilizers-history-production-and-applications",title:"Organic Fertilizers",fullTitle:"Organic Fertilizers - History, Production and Applications"},signatures:"Pham Van Toan, Ngo Duc Minh and Dao Van Thong",authors:null},{id:"62186",title:"Olive-Pressed Solid Residues as a Medium for Growing Mushrooms and Increasing Soil Fertility",slug:"olive-pressed-solid-residues-as-a-medium-for-growing-mushrooms-and-increasing-soil-fertility",totalDownloads:1093,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Organic fertilizer is the core of organic farming, which represents the most important way to provide crops and agricultural products that are safe and free of any chemical components and pesticides. From this point of view, the purpose of this study is to provide a source of organic fertilizers which was formerly an environmental problem. The northwestern region of Saudi Arabia is flourishing with olive production, leaving huge amounts of residues called olive press cake (OPC). These wastes are a major environmental pollution despite their good content of carbohydrates, protein, oil and cellulose alongside phenols and lignin. We tested the cultivation of Gliocladium roseum, Pythium oligandrum and Trichoderma harzianum and the mushroom Pleurotus ostreatus on OPC in order to reduce the high percentage of phenols that impede the germination of some plant seeds. Gliocladium roseum, Pythium oligandrum and Pleurotus ostreatus were able to reduce the percentage of phenols to more than 40% and thus support germination of seeds of Eruca sativa. This study gave than one benefit: firstly, reducing phenols that impede the germination of seeds. Secondly, Gliocladium roseum and Pythium oligandrum work against some plant diseases and also produce plant-like hormones that increase growth of plants.",book:{id:"7216",slug:"soil-productivity-enhancement",title:"Soil Productivity Enhancement",fullTitle:"Soil Productivity Enhancement"},signatures:"Hani Mohamed Awad Abdelzaher, Haifa Abdulaziz S. Alhaithloul\nand Shaima Mohamed Nabil Moustafa",authors:[{id:"238130",title:"Dr.",name:"Shaima",middleName:"Mohamed Nabil",surname:"Moustafa",slug:"shaima-moustafa",fullName:"Shaima Moustafa"},{id:"242818",title:"Prof.",name:"Hani",middleName:"Mohamed Awad",surname:"Abdelzaher",slug:"hani-abdelzaher",fullName:"Hani Abdelzaher"},{id:"245646",title:"Dr.",name:"Haifa",middleName:null,surname:"Alhaithloul",slug:"haifa-alhaithloul",fullName:"Haifa Alhaithloul"}]},{id:"68604",title:"Composting",slug:"composting",totalDownloads:1098,totalCrossrefCites:0,totalDimensionsCites:2,abstract:"Decomposition followed by stabilization of organic substances by biological actions has been taking place in nature from the very beginning of life appeared on our planet. Anthropogenic control and utilization of the process for sanitary disposal and reclamation of organic waste material have been termed composting and the final product is named compost. Microbial community leads the processes of both aerobic and anaerobic composting and converts wastes to a stable form of nutrients. The C/N ratio is the most important factor for decomposition, especially aerobic decomposition. Microorganisms respire two-third of carbon as CO2, and one-third combines with nitrogen in living cell, and huge amount of heat energy is released as end product of aerobic decomposition as compared to anaerobic process. In agricultural world, utilization of human and animal wastes has great importance. Extensive studies on composting were initiated in India. Different composting methods like pit method, heap method, ADCO method, vermicomposting, etc. presently exist in the world. Humus is the end product of composting, and different organic wastes contain macro, micro, and trace elements, which reflect valuable properties for growing vegetation and to the soil itself.",book:{id:"8017",slug:"organic-fertilizers-history-production-and-applications",title:"Organic Fertilizers",fullTitle:"Organic Fertilizers - History, Production and Applications"},signatures:"Niladri Paul, Utpal Giri and Gourab Roy",authors:null},{id:"67957",title:"Efficacy of Different Substrates on Vermicompost Production: A Biochemical Analysis",slug:"efficacy-of-different-substrates-on-vermicompost-production-a-biochemical-analysis",totalDownloads:1036,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"The rapid increase in the volume of waste is one aspect of the environment crisis, accompanying global development. Earthworms play an important role in the decomposition of organic matter and soil metabolism through feeding, fragmentation, aeration, turnover and dispersion. The type of substrates used and species of earthworms introduced plays a significant role in plant growth and yield. The waste to be stabilized should support an adequate biomass needed for effective processing. In the present study the vermicompost produced from banana as a substrate did not show a significant increase in NPK content from that of the control. On the other hand poultry waste and vegetable waste with goat dung showed significant increase in the NPK content. The enhancement of the vermicompost was probably due to mineralization of the organic matter containing proteins and conversion of ammonium nitrogen into nitrite. Mineralization and consequent mobilization of phosphorous by enhanced bacterial and phosphatase activities during vermicomposting leads to increase in Phosphorus. The earthworm processed waste materials contain high concentration of exchangeable potassium, due to enhanced microbial activity during the vermicomposting process, which accordingly enhanced the rate of mineralization. Vermicompost tends to hold more nutrients over larger periods without adverse effects on the environment.",book:{id:"8017",slug:"organic-fertilizers-history-production-and-applications",title:"Organic Fertilizers",fullTitle:"Organic Fertilizers - History, Production and Applications"},signatures:"Pawlin Vasanthi Joseph",authors:null}],onlineFirstChaptersFilter:{topicId:"677",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:31,numberOfPublishedChapters:314,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:16,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:4,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:14,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}]},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",biography:"Michele Lanza is Associate Professor of Ophthalmology at Università della Campania, Luigi Vanvitelli, Napoli, Italy. His fields of interest are anterior segment disease, keratoconus, glaucoma, corneal dystrophies, and cataracts. His research topics include\nintraocular lens power calculation, eye modification induced by refractive surgery, glaucoma progression, and validation of new diagnostic devices in ophthalmology. \nHe has published more than 100 papers in international and Italian scientific journals, more than 60 in journals with impact factors, and chapters in international and Italian books. He has also edited two international books and authored more than 150 communications or posters for the most important international and Italian ophthalmology conferences.",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}]},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. 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In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"9",type:"subseries",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11405,editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",biography:"Dr. Luis Villarreal is a research professor from the Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana, Baja California, México. Dr. Villarreal is the editor in chief and founder of the Revista de Ciencias Tecnológicas (RECIT) (https://recit.uabc.mx/) and is a member of several editorial and reviewer boards for numerous international journals. He has published more than thirty international papers and reviewed more than ninety-two manuscripts. 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This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/304929",hash:"",query:{},params:{id:"304929"},fullPath:"/profiles/304929",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()