Kristina Khacheva

By Olga Vladimirovna Vorob’eva, Victoria Vyacheslavovna Fateeva, Ksenia Vladimirovna Nikulina, Kristina Konstantinovna Khacheva, Gulnara Rinatovna Khakimova and Oleg Ilyich Epstein

The authors present an analysis of current research and their own data on the link between endothelial dysfunction (ED) and the severity of depression in middle-aged patients with cerebral microangiopathy. Levels of peripheral inflammatory and endothelial dysfunction markers were measured using the enzyme-linked immunosorbent assay (ELISA). The results of the comparative and correlation analyses showed a statistically significant correlation between the severity of depression and increased levels of inflammatory, as well as endothelial dysfunction.

Part of the book: Basic and Clinical Understanding of Microcirculation

By Kristina Konstantinovna Khacheva, Gulnara Rinatovna Khakimova, Alexey Borisovich Glazunov and Victoria Vyacheslavovna Fateeva

Neurotic disorders (NDs) are among the most common mental diseases leading to a decrease in the quality of life, lack of socialization, and increased mortality. The diagnosis and treatment of all types of NDs are challenging. In the light of the ongoing search for an effective and safe therapeutic strategy influencing certain aspects of ND pathogenesis, technologically processed highly diluted antibodies to S100 protein (TP Abs to S100) seem to be a promising treatment option for patients with NDs. TP Abs to S100 possess stress-protective, anxiolytic, antidepressant, antiamnestic, and neuroprotective activities. In the current review, we describe the mechanisms of action and pharmacological effects of TP Abs to S100 demonstrated in nonclinical (preclinical) and clinical studies. Based on the data, we tried to evaluate the future prospects of the TP Abs to S100 as the drug of choice for ND treatment.

Part of the book: Anxiety Disorders