Dr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
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Seeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\\n\\n
Over these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\\n\\n
We are excited about the present, and we look forward to sharing many more successes in the future.
\\n\\n
Thank you all for being part of the journey. 5,000 times thank you!
\\n\\n
Now with 5,000 titles available Open Access, which one will you read next?
Preparation of Space Experiments edited by international leading expert Dr. Vladimir Pletser, Director of Space Training Operations at Blue Abyss is the 5,000th Open Access book published by IntechOpen and our milestone publication!
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"This book presents some of the current trends in space microgravity research. The eleven chapters introduce various facets of space research in physical sciences, human physiology and technology developed using the microgravity environment not only to improve our fundamental understanding in these domains but also to adapt this new knowledge for application on earth." says the editor. Listen what else Dr. Pletser has to say...
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Dr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
\n\n
Seeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\n\n
Over these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\n\n
We are excited about the present, and we look forward to sharing many more successes in the future.
\n\n
Thank you all for being part of the journey. 5,000 times thank you!
\n\n
Now with 5,000 titles available Open Access, which one will you read next?
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6186",leadTitle:null,fullTitle:"Carbon Dioxide Chemistry, Capture and Oil Recovery",title:"Carbon Dioxide Chemistry, Capture and Oil Recovery",subtitle:null,reviewType:"peer-reviewed",abstract:"Fossil fuels still need to meet the growing demand of global economic development, yet they are often considered as one of the main sources of the CO2 release in the atmosphere. CO2, which is the primary greenhouse gas (GHG), is periodically exchanged among the land surface, ocean, and atmosphere where various creatures absorb and produce it daily. However, the balanced processes of producing and consuming the CO2 by nature are unfortunately faced by the anthropogenic release of CO2. Decreasing the emissions of these greenhouse gases is becoming more urgent. Therefore, carbon sequestration and storage (CSS) of CO2, its utilization in oil recovery, as well as its conversion into fuels and chemicals emerge as active options and potential strategies to mitigate CO2 emissions and climate change, energy crises, and challenges in the storage of energy.",isbn:"978-1-78923-575-3",printIsbn:"978-1-78923-574-6",pdfIsbn:"978-1-83881-322-2",doi:"10.5772/intechopen.68466",price:119,priceEur:129,priceUsd:155,slug:"carbon-dioxide-chemistry-capture-and-oil-recovery",numberOfPages:266,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"720a601cd2b5476cbeb817906a4ab2dd",bookSignature:"Iyad Karamé, Janah Shaya and Hassan Srour",publishedDate:"August 16th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6186.jpg",numberOfDownloads:25031,numberOfWosCitations:46,numberOfCrossrefCitations:41,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:98,numberOfDimensionsCitationsByBook:3,hasAltmetrics:1,numberOfTotalCitations:185,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 11th 2017",dateEndSecondStepPublish:"May 2nd 2017",dateEndThirdStepPublish:"December 14th 2017",dateEndFourthStepPublish:"January 14th 2018",dateEndFifthStepPublish:"March 14th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"145512",title:"Prof.",name:"Iyad",middleName:null,surname:"Karamé",slug:"iyad-karame",fullName:"Iyad Karamé",profilePictureURL:"https://mts.intechopen.com/storage/users/145512/images/3352_n.jpg",biography:"Iyad Karamé, PhD.\nHe is a professor at the Faculty of sciences in the Lebanese University in Beirut. Director of the Organometallic Catalysis and Materials Laboratory, in the department of Chemistry. He got his PhD degree from Claude Bernard-Lyon 1 university in France in January 2004. He was an assistant professor and researcher (ATER) at the Ecole Normale Supérieure de Lyon, France, for one year (2004-2005). A researcher at the Leibniz Institut für Katalyse in Rostock (Germany) (2005-2006) and then at the Laboratory of Organometallic Chemistry of surface, CPE-Lyon till 2008. His principal axis of research are Organometallic Catalysis, Green Chemistry, CO2 chemistry and Synthesis of chelating macrocyles for the complexation of metals.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"Lebanese University",institutionURL:null,country:{name:"Lebanon"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"205624",title:"Dr.",name:"Janah",middleName:null,surname:"Shaya",slug:"janah-shaya",fullName:"Janah Shaya",profilePictureURL:"https://mts.intechopen.com/storage/users/205624/images/5266_n.jpg",biography:"He is a postdoctoral fellowship with the CNRS at the IPCMS of strasbourg (Institut de Physique et Chimie des Matériaux de Strasbourg) in collaboration with Kyushu University, Japan. He got his PhD degree from University of Nice, Sophia Antipolis in France in September 2016. His principal axes of research are organic synthesis, catalysis (cross couplings and CH activataion), photophysics electrochemistry, material science and applications (energy storage systems and CO2 valorization). He is currently the co-editor of two books on cross couplings and Carbon dioxide chemistry.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Univerzitná Nemocnica Louisa Pasteura",institutionURL:null,country:{name:"Slovakia"}}},coeditorTwo:{id:"195431",title:"Dr.",name:"Hassan",middleName:null,surname:"Srour",slug:"hassan-srour",fullName:"Hassan Srour",profilePictureURL:"https://mts.intechopen.com/storage/users/195431/images/4969_n.jpg",biography:"Got his PhD degree from University of Claude Bernard Lyon 1 in France in October 2013. His principal axes of research are organic synthesis, polymer electrolytes, organometallic catalysis for different applications (energy storage systems and CO2 valorization). He is an editor of different books published by INTECHOPEN such as: “Recent Advances of Organocatalysis”, Green chemical processing and synthesis and Carbon Dioxide (CO2) Chemistry, Capture and Oil Recovery.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"700",title:"Inorganic Chemistry",slug:"engineering-chemical-engineering-inorganic-chemistry"}],chapters:[{id:"62317",title:"Introductory Chapter: An Outline of Carbon Dioxide Chemistry, Uses and Technology",doi:"10.5772/intechopen.79461",slug:"introductory-chapter-an-outline-of-carbon-dioxide-chemistry-uses-and-technology",totalDownloads:1601,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:1,abstract:null,signatures:"Janah Shaya, Hassan Srour and Iyad Karamé",downloadPdfUrl:"/chapter/pdf-download/62317",previewPdfUrl:"/chapter/pdf-preview/62317",authors:[{id:"145512",title:"Prof.",name:"Iyad",surname:"Karamé",slug:"iyad-karame",fullName:"Iyad Karamé"}],corrections:null},{id:"60087",title:"Electrochemical/Photochemical CO2 Reduction Catalyzed by Transition Metal Complexes",doi:"10.5772/intechopen.75199",slug:"electrochemical-photochemical-co2-reduction-catalyzed-by-transition-metal-complexes",totalDownloads:1901,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Conversion of CO2 into useful chemicals is attractive as a solution of the fossil fuel shortage and the global warming problems. Reduction of CO2 into carbon monoxide (CO) and formic acid (HCOOH) is also important for obtaining the materials in organic syntheses. There are a lot of studies on the catalysts for electrochemical/photochemical CO2 reduction. Especially, transition metal complexes have actively researched as the molecular catalysts for CO2 reduction. In this chapter, the electrochemical/photochemical CO2 reduction catalyzed by cis-[Ru(bpy)2(CO)2]2+ (bpy: 2,2′-bipyridine) and trans(Cl)-[Ru(bpy)(CO)2Cl2] is described as a representative example.",signatures:"Hitoshi Ishida",downloadPdfUrl:"/chapter/pdf-download/60087",previewPdfUrl:"/chapter/pdf-preview/60087",authors:[{id:"210140",title:"Dr.",name:"Hitoshi",surname:"Ishida",slug:"hitoshi-ishida",fullName:"Hitoshi Ishida"}],corrections:null},{id:"59836",title:"Carbon Dioxide Conversion to Methanol: Opportunities and Fundamental Challenges",doi:"10.5772/intechopen.74779",slug:"carbon-dioxide-conversion-to-methanol-opportunities-and-fundamental-challenges",totalDownloads:5519,totalCrossrefCites:10,totalDimensionsCites:18,hasAltmetrics:1,abstract:"Greenhouse gases mitigation is one of most important challenges facing societies nowadays. Therefore, the way to reduce greenhouse gas emissions should be using carbon free sources that do not generate extra CO2 to the atmosphere. However, there is a great potential in energy carriers and other materials from CO2, with many challenges to overcome. It has been suggested that the reduction of CO2 and conversion to renewable fuels and valuable chemicals may be considered as a promising solution to reduce the greenhouse gas emissions. This chapter discusses the recent developments and remaining challenges of CO2 utilization for the efficient production of methanol. This includes novel technologies, approaches, and current barriers for the conversion of CO2 to methanol through heterogeneous catalysis, homogenous catalysis, electrochemical, photochemical, and photoelectrochemical conversion, which will contribute to the economic growth and mitigate the hazardous emissions for cleaner environment. A review of various state-of-the-art technologies for CO2 conversion to methanol was carried out aiming to establish the advances in this area and present an overview of the recent research trend for future development of new ideas for CO2 reduction into methanol in a large scale.",signatures:"Sajeda A. Al-Saydeh and Syed Javaid Zaidi",downloadPdfUrl:"/chapter/pdf-download/59836",previewPdfUrl:"/chapter/pdf-preview/59836",authors:[{id:"193992",title:"Prof.",name:"Syed",surname:"Zaidi",slug:"syed-zaidi",fullName:"Syed Zaidi"},{id:"233125",title:"MSc.",name:"Sajeda",surname:"Alsaydeh",slug:"sajeda-alsaydeh",fullName:"Sajeda Alsaydeh"}],corrections:null},{id:"56776",title:"Effect of Overlapping Fe/TiO2 Coated on Netlike Glass Disc and Cu Disc on CO2 Reduction",doi:"10.5772/intechopen.70389",slug:"effect-of-overlapping-fe-tio2-coated-on-netlike-glass-disc-and-cu-disc-on-co2-reduction",totalDownloads:1103,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Fe-doped TiO2 (Fe/TiO2) film photocatalyst was prepared by sol-gel and dip-coating process to respond to the visible spectrum. Netlike glass fiber and Cu disc that are base materials used for coating Fe/TiO2 were investigated to promote the CO2 reduction performance of the photocatalyst. The prepared Fe/TiO2 film coated on netlike glass fiber and Cu disc was characterized by scanning electron microscope (SEM) and electron probe micro analyzer (EPMA). Additionally, the CO2 reduction experiment using Fe/TiO2 film coated on netlike glass disc, Cu disc, and their overlap was carried out by illuminating an Xe lamp or without ultraviolet (UV) light, respectively. As a result, the concentration of produced CO increases by Fe doping irrespective of base material used under the illumination condition with UV light as well as without UV light. The peak concentration of CO for the Fe/TiO2 double overlapping is approximately 1.5 times as large as the Fe/TiO2 single overlapping under the illumination condition with UV light due to the promotion of electron transfer between the two overlapped photocatalysts. However, the promotion ratio is approximately 1.1 times under the illumination condition without UV light.",signatures:"Akira Nishimura",downloadPdfUrl:"/chapter/pdf-download/56776",previewPdfUrl:"/chapter/pdf-preview/56776",authors:[{id:"52804",title:"Associate Prof.",name:"Akira",surname:"Nishimura",slug:"akira-nishimura",fullName:"Akira Nishimura"}],corrections:null},{id:"59241",title:"CO2 Reforming with CH4 via Plasma Catalysis System",doi:"10.5772/intechopen.73579",slug:"co2-reforming-with-ch4-via-plasma-catalysis-system",totalDownloads:1424,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Reforming of CO2 and CH4 into syngas (mixture of H2/CO) can be an economical way to reduce anthropogenic emission of CO2 and CH4 and to generate alternative fuel. Up to date, catalysis and nonthermal plasma are two feasible techniques for CO2/CH4 reforming. However, both techniques face some obstacles which limit their applications. For catalysis, high energy consumption and catalyst deactivation are the major disadvantages while nonthermal plasma has the drawbacks of low selectivity and unwanted byproduct formation. To overcome the above obstacles, combining catalyst and nonthermal plasma as a hybrid system can induce synergistic effects to enhance syngas production rate and stability of the operating system. For the purpose of enhancing CO2 utilization efficiency, understanding the interactions between catalyst and nonthermal plasma is essential.",signatures:"Wei Chieh Chung and Moo Been Chang",downloadPdfUrl:"/chapter/pdf-download/59241",previewPdfUrl:"/chapter/pdf-preview/59241",authors:[{id:"42014",title:"Prof.",name:"Moo-Been",surname:"Chang",slug:"moo-been-chang",fullName:"Moo-Been Chang"},{id:"210223",title:"Ph.D. Student",name:"Wei Chieh",surname:"Chung",slug:"wei-chieh-chung",fullName:"Wei Chieh Chung"}],corrections:null},{id:"58864",title:"Understanding Interaction Capacity of CO2 with Organic Compounds at Molecular Level: A Theoretical Approach",doi:"10.5772/intechopen.71878",slug:"understanding-interaction-capacity-of-co2-with-organic-compounds-at-molecular-level-a-theoretical-ap",totalDownloads:1189,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"In this chapter, interactions of CO2 with a number of organic compounds at molecular level are discussed in detail. The naked and substituted hydrocarbons along with compounds functionalized by hydroxyl, carbonyl, thiocarbonyl, carboxyl, sulfonyl, and amide groups have attracted much attention as CO2-philic agents. In general, interaction capacity between the functionalized organic compounds with CO2 is stronger than the hydrocarbon and its derivatives. An addition of more CO2 molecules into the interaction system formed by the functionalized organic compounds and CO2 leads to an increase in the stability of the complexes. The obtained results indicate that π…π linkages between CO2 and aromatic rings can significantly contribute to the interactions between CO2 and MOF/ZIF materials. Formic acid (HCOOH) is likely to be the most soluble compound as compared to the remaining host molecules (CH3OH, CH3NH2, HCHO, HCOOCH3, and CH3COCH3) when dissolved in CO2. The carbonyl (>C═O, >C═S) and sulfonyl (>S═O, >S═S) compounds have presented a higher stability, as compared to other functionalized groups, when they interact with CO2. Therefore, they can be valuable candidates in the design of CO2-philic materials and in the search of materials to adsorb CO2.",signatures:"Pham Ngoc Khanh and Nguyen Tien Trung",downloadPdfUrl:"/chapter/pdf-download/58864",previewPdfUrl:"/chapter/pdf-preview/58864",authors:[{id:"216650",title:"Associate Prof.",name:"Tien Trung",surname:"Nguyen",slug:"tien-trung-nguyen",fullName:"Tien Trung Nguyen"},{id:"216697",title:"Dr.",name:"Ngoc Khanh",surname:"Pham Ngoc Khanh",slug:"ngoc-khanh-pham-ngoc-khanh",fullName:"Ngoc Khanh Pham Ngoc Khanh"}],corrections:null},{id:"58065",title:"[11C]Carbon Dioxide: Starting Point for Labeling PET Radiopharmaceuticals",doi:"10.5772/intechopen.72313",slug:"-11c-carbon-dioxide-starting-point-for-labeling-pet-radiopharmaceuticals",totalDownloads:1748,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Positron emission tomography (PET) is a powerful in vivo imaging technique capable of providing dynamic information on biochemical processes in the living human subject. Applications of PET in oncology, neurology, psychiatry, cardiology and other medical specialties continue to grow. The use of PET relies on the characteristics and availability of appropriately labeled radiopharmaceuticals. Carbon-11 is one of the most useful radionuclides for PET chemistry, since its introduction into a biologically active molecule dose not modify the biochemical properties of the compound. [11C]Carbon dioxide (11CO2), produced by cyclotron, is the most common and versatile primary labeling precursor in the production of 11C–labeled radiopharmaceuticals.",signatures:"Lingyun Yang, Peter J. H. Scott and Xia Shao",downloadPdfUrl:"/chapter/pdf-download/58065",previewPdfUrl:"/chapter/pdf-preview/58065",authors:[{id:"62856",title:"Dr.",name:"Peter",surname:"Scott",slug:"peter-scott",fullName:"Peter Scott"},{id:"210271",title:"Dr.",name:"Xia",surname:"Shao",slug:"xia-shao",fullName:"Xia Shao"},{id:"220632",title:"Dr.",name:"Lingyun",surname:"Yang",slug:"lingyun-yang",fullName:"Lingyun Yang"}],corrections:null},{id:"57510",title:"Solvents for Carbon Dioxide Capture",doi:"10.5772/intechopen.71443",slug:"solvents-for-carbon-dioxide-capture",totalDownloads:4055,totalCrossrefCites:15,totalDimensionsCites:39,hasAltmetrics:1,abstract:"Anthropogenic CO2 emissions are considered the major contributor of greenhouse gas emissions worldwide. The mitigation of this kind of CO2 emissions relies on a portfolio of alternatives where CO2 absorption appears as the nearest approach to be applied at industrial scale. Researchers have been focused on developing new formulations of solvents to make more competitive CO2 absorption as a carbon capture and storage (CCS) technology. In this sense, this chapter summarizes both the conventional solvents and the most recent investigations on this field. Chemical absorption is more suitable for a lot of industrial process due to the flue gas conditions: ambient pressure, low CO2 concentration and large volume. Therefore numerous novel solvents came up in recent years and they are further discussed in this chapter. The most recent solvents, their mechanisms and kinetics and the advantages and disadvantages are also included. Finally, physical solvents are adequate in high CO2 partial pressure applications and they are reported in the last section. Although physical absorption field is constrained to high-pressure flue gas, physical solvents provided higher performance in CO2 separation process and their characteristics are also summarized.",signatures:"Fernando Vega, Mercedes Cano, Sara Camino, Luz M. Gallego\nFernández, Esmeralda Portillo and Benito Navarrete",downloadPdfUrl:"/chapter/pdf-download/57510",previewPdfUrl:"/chapter/pdf-preview/57510",authors:[{id:"10704",title:"Prof.",name:"Benito",surname:"Navarrete",slug:"benito-navarrete",fullName:"Benito Navarrete"},{id:"209759",title:"Dr.",name:"Fernando",surname:"Vega",slug:"fernando-vega",fullName:"Fernando Vega"},{id:"218843",title:"Dr.",name:"Mercedes",surname:"Cano",slug:"mercedes-cano",fullName:"Mercedes Cano"},{id:"218844",title:"Mrs.",name:"Sara",surname:"Camino",slug:"sara-camino",fullName:"Sara Camino"},{id:"218845",title:"Mrs.",name:"Luz. M.",surname:"Gallego Fernández",slug:"luz.-m.-gallego-fernandez",fullName:"Luz. M. Gallego Fernández"},{id:"218846",title:"Mrs.",name:"Esmeralda",surname:"Portillo",slug:"esmeralda-portillo",fullName:"Esmeralda Portillo"}],corrections:null},{id:"57000",title:"Advances in Porous Adsorbents for CO2 Capture and Storage",doi:"10.5772/intechopen.70796",slug:"advances-in-porous-adsorbents-for-co2-capture-and-storage",totalDownloads:1738,totalCrossrefCites:5,totalDimensionsCites:13,hasAltmetrics:0,abstract:"The steady increase of anthropogenic CO2 in ambient air, owing to the fossil fuel, power plants, chemical processing and deforestation caused by the usage of land, is a key challenge in the on-going effort to diminish the effect of greenhouse gases on global climate change by developing efficient techniques for CO2 capture. Global warming as a consequence of high CO2 level in the atmosphere is considered as one of the major long lasting problems in the twenty-first century. Concern over these major issues with regard to severe climate change and ocean acidification motivated us to develop the technologies that capture the evolved CO2 from entering into the carbon cycle. Therefore, CO2 capture and storage technology is attracting increasing interest in order to reduce carbon level in the atmosphere which in turn mitigates global climate issues. In this regard, highly efficient adsorbents e.g.; zeolites, alkali metal oxides, activated carbon, porous silica show considerable progress in post combustion CO2 capture. Recently, metal-organic frameworks (MOFs), porous organic polymers (POPs), porous clays, N-doped carbon etc. are explored as versatile and quite elegant way for next-generation CO2 capture. In this chapter, we will discuss the broad prospect of MOFs, POPs, nanoporous clays and porous carbon for CO2 storage and sequestration through utilization of their nanospace chemistry.",signatures:"Arindam Modak and Subhra Jana",downloadPdfUrl:"/chapter/pdf-download/57000",previewPdfUrl:"/chapter/pdf-preview/57000",authors:[{id:"213796",title:"Dr.",name:"Subhra",surname:"Jana",slug:"subhra-jana",fullName:"Subhra Jana"},{id:"218439",title:"Dr.",name:"Arindam",surname:"Modak",slug:"arindam-modak",fullName:"Arindam Modak"}],corrections:null},{id:"60759",title:"Process Analytical Technology for CO2 Capture",doi:"10.5772/intechopen.76176",slug:"process-analytical-technology-for-co2-capture",totalDownloads:1272,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Carbon capture and storage, which is also known as CCS, is an obligatory climate change mitigation technology to reduce the carbon dioxide gas emissions to the atmosphere thus limiting the average global temperature increase to 2°C. Process analytical technology is a scientific tool to improve process qualities and performance through timely measurements. This chapter describes how process analytical technology can be imbedded to a carbon capture technology by giving a detailed example of implementation of a process analyzer to CO2 capture by alkanolamine absorption process. Such an implementation requires success in five elements, which are described in this chapter. They are as follows: selecting an appropriate process analyzer, integration between the analyzer and the process, model development to enable the analyzer to predict a process-related chemical or physical attribute, use of the developed model in real-time application and use of the data obtained from the analyzer as an input to a process control unit. Partial least square regression model is a useful chemometric-based method to extract hidden chemical information in measurements from a process analyzer. In this chapter, four partial least square regression models are presented, which are developed to predict CO2 concentration for four different alkanolamine solutions when these amines are used to absorb CO2 from a combustion process.",signatures:"M.H. Wathsala N. Jinadasa, Klaus-J. Jens and Maths Halstensen",downloadPdfUrl:"/chapter/pdf-download/60759",previewPdfUrl:"/chapter/pdf-preview/60759",authors:[{id:"231531",title:"Dr.",name:"M.H. Wathsala",surname:"Jinadasa",slug:"m.h.-wathsala-jinadasa",fullName:"M.H. Wathsala Jinadasa"},{id:"231535",title:"Prof.",name:"Maths",surname:"Halstensen",slug:"maths-halstensen",fullName:"Maths Halstensen"},{id:"231536",title:"Prof.",name:"Klaus-Joachim",surname:"Jens",slug:"klaus-joachim-jens",fullName:"Klaus-Joachim Jens"}],corrections:null},{id:"58923",title:"Carbon Dioxide Use in High-Pressure Extraction Processes",doi:"10.5772/intechopen.71151",slug:"carbon-dioxide-use-in-high-pressure-extraction-processes",totalDownloads:1844,totalCrossrefCites:2,totalDimensionsCites:7,hasAltmetrics:1,abstract:"This chapter describes the use of carbon dioxide at high pressures as an alternative for the extraction of bioactive compounds in a more sustainable way, addressing some of its physicochemical properties, such as pressure, temperature, density, solvation, selectivity, and its interaction with the solute when modified by other solvents such as ethanol and water. 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1. Introduction
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Phosphazenes, which are cyclic or linear chain inorganic compounds formed by the bonding and repetition of phosphorus and nitrogen atoms with (P=N)n bonds, comprise an important class of inorganic compounds (Figure 1). There are many phosphazene compounds ranging from oligomers to polymers. Among the phosphazene compounds, the hexachlorocyclotriphosphazene (N3P3Cl6, trimer) and octachlorocyclotetraphosphazene (N4P4Cl8, tetramer) derivatives have attracted considerable attention (Figure 1a,b) [1]. The reaction of PCl5 with NH4Cl in a chlorinated solvent gives a mixture of colorless solids of the formula (NPCl2)n. As the most popular compounds N3P3Cl6 and N4P4Cl8 are readily separated by distillation under reduced pressure. Cyclic phosphazene compounds containing five, six, seven and higher -P=N units are also known, but these compounds are not very common [2]. Polyphosphazenes are inorganic–organic polymers containing alternate phosphorus and nitrogen atoms, each skeletal phosphorus atom having bonds with one or more organic or inorganic substituent (Figure 1c) [3].
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Figure 1.
Phosphazene structures.
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Phosphazenes exhibit highly customizable physical and chemical characteristics which depend on the substituents bonded to the phosphorus atom. Thus, they have found wide application in a variety of fields involving their use in rechargeable batteries [4], membranes [5] and lubricants [6], liquid crystals [7], anticancer agents [8], antibacterial reagents [9], flame-retardants [10], biological materials [11], and synthetic bones [12].
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This chapter deals with the structures and applications of PzILs which are formed by quaternization of the ring nitrogen or phosphorus in the phosphazene, or the nitrogen atom in the substituent bonded to the phosphorus atom.
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\n
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2. Phosphazene-based ionic liquids
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The PzIL consists of repeating phosphorus-nitrogen units having a pendant group bonded to the phosphorus atoms of the phosphazene. PzILs may have cyclic or linear structure (Figure 2). The positive charge is positioned in a substituent attached to the phosphorus atom, or in the skeleton nitrogen or phosphorus atom. The positive charge’s position is reported to be effective on the stability, viscosity and other properties of PzIL [13].
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Figure 2.
General chemical structure of PzILs.
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2.1. Phosphazene-based ionic liquids in which quaternization occurs on the nitrogen atom or phosphorus atom of phosphazene
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Ring and the exocyclic nitrogens are two possible basic sites of cyclophosphazenes. The formation of the protonation and the pKa′ values of cyclophosphazene derivatives were investigated in the literature [14, 15, 16]. The ring-nitrogen protonation of cyclophosphazene bases with HCl, HBr, HF, HClO4, and CH3COOH were supported by infrared and NMR data [17, 18]. The protonation of the ring was determined by the crystal structure of N3P3Cl2(NHPri)4.HCI and [N3P3HCl4(NH2)2]+ [N(POCl2)2]− (Figure 3) [19, 20].
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Figure 3.
The crystal structure of [N3P3HCl4(NH2)2]+ [N(POCl2)2]−.
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Reportedly, the reactions of N3P3Cl6 with AlCl3, AlBr3, GaCl3 under anaerobic conditions or in the presence of water or HX yielded protonated phosphazenes P3N3Cl6.HMX4. The protonated specie distorted the P3N3 ring and weakened the two P − N bonds that flank the protonated nitrogen. The crystal structures of N3P3Cl6·HAlCl4, N3P3Cl6·HGaCl4, N3P3Cl6·HAlBr4 are shown in Figure 4 [21, 22].
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Figure 4.
The crystal structures of N3P3Cl6·HMX4, (a) N3P3Cl6·HAlCl4; (b) N3P3Cl6·HGaCl4; (c) N3P3Cl6·HAlBr4.
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Despite the low basicity and nucleophilicity, various phosphazenium compounds have been obtained using potent electrophilic reagents based on carborane anions. (Figure 5) [18].
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Figure 5.
N-protonated, N-methylated, and N-silylated adducts of N3P3Cl6.
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N-alkyl phosphazenium cations are obtained by alkylation of the ring nitrogen atom of cyclotriphosphazenes containing organoamino substituents with alkyl halides (Figure 6). As observed in the X-ray crystal structures, the associated P-N bonds of the alkylation of the ring N sites are significantly longer. Highly stable phosphazenium salts generate complex supramolecular networks with NH…X interactions in the solid state (Figure 7). N-Alkyl phosphazenium salts react with silver nitrate to form complexes with silver ions. Depending on the steric requirement of the RNH substituents, one or both of the free ring nitrogen sites are coordinated with silver ions (Figure 8) [23].
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Figure 6.
N-alkyl phosphazenium salts.
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Figure 7.
Supramolecular structure of (1Me)I. The dashed lines show hydrogen bonds.
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Figure 8.
The crystal structure of Ag2[2Me](NO3)3.H2O.
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Industrial application of High performance nonmetallic molecular phosphazene catalysts involves the synthesis of polypropylene glycols (PPGs). Phosphazenium salts (PZN) have giant cations that are 10–12 Å in diameter and they exhibit unique catalytic behavior in various anionic organic reactions that are highly demanded in chemical industry (Figure 9). Reportedly, a phosphazenium ion (a macrocationic species), should considerably activate anionic active species [24, 25].
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Figure 9.
Chemical structure of phosphazenium salt (PZN).
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Organophosphazenes bearing -OR substituted groups are readily quaternized at the ring nitrogen atoms to form phosphazene cations with alkyl halides, methyl trifluoromethanesulfonate (CF3SO3CH3) or trimethyloxonium tetrafluoroborate [(CH3)3O(BF4)] (Figure 10). Lower electron densities at the ring nitrogen atoms render alkoxy or aryloxy-substituted cyclotriphosphazenes inert to iodomethane at room temperature or lead to the rearrangement of the alkoxyphosphazene to the N-alkyloxophosphazane at higher temperatures [26].
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Figure 10.
Quaternization of the cyclotriphosphazenes.
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The transition metal chemistry of cyclophosphazenes has also attracted great interest. The nature of cyclophosphazene-adducted compounds usually depends both on the phosphazene base and the corresponding Lewis acid. For example, for the N6P6(NMe2)12.CuCl2, Lewis acid is not bonded to a particular ring atom. However, it is located on the ring and is attached to more than one nitrogen atom [27]. A mono protonated (amino) spiro cyclic cyclotriphosphazene salt was synthesized and its crystal structure was clarified. The protonation occurs at one of the nitrogen atoms adjacent to the spiro phosphorus atom of the P3N3 ring (Figure 11). The protonation caused elongation of the P-N bonds in the ring and puckering of the phosphazene ring. In the crystal lattice, 2n cyclophosphazenium cations are connected by n[PtCl4]2− anions with N-H…Cl hydrogen bonds to generate a linear polymeric structure [28]. A great number of cyclophosphazenium cations with metal anions, such as [HN3P3(NMe2)6]2[Mo6O19], [HN3P3(NMe2)6]2[CoCl4], [MeN4P4Me8][Cr(CO)5I], [HN4P4Me8]2[CoCl4], [H2N4P4Me8][PtCl4] and [H2N5P5Me10][CuCl4], have been obtained.
2.2. Phosphazene-based ionic liquids in which quaternization occurs on a pendant group of phosphazene bonded to a phosphorus atom
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Due to the more sterically suitable positions of the nitrogen atoms of the phosphazene ring, the alkylation occurred at the exocyclic nitrogen atoms Rapko and Feistel presented the parameters in their study on the dialkyl cation of hexakisdimethylamino cyclotriphosphazene ([N3P3(NMe2)6(Me)2]2+[(BF4ˉ)2]), (Figure 12). The position of the alkylation was investigated by hydrolytic degradation of the obtained cyclotriphosphazene salts [29].
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Figure 12.
The synthesis of dimethyl hexakisdimethylamino cyclotriphosphonitrilium difluoroborate.
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Allcock et al. synthesized phosphazenium iodide salts by quaternization of several cyclic phosphazenes either at side-group sites or at the skeletal nitrogen atom (Figure 13). With the exception of piperidino derivatives, in which case the reactive sites were the skeletal nitrogen atoms, quaternization occurred at the side-group sites. The compound N3P3(OC6H5)5N(CH3)2 was not quaternized, since the side-group nitrogen atoms are directly attached to the phosphazene ring due to their protected or inactivated nature [30].
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Figure 13.
Various cyclotriphosphazenium iodide salts.
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2.3. Applications of phosphazene-based ionic liquids
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PzILs are prepared by quaternization of a wide variety of phosphazenes either at the side-group or at the skeletal nitrogen atoms. These ILs have been used as anticancer, antibacterial reagents [31, 32, 33, 34], adsorbents and surface modifiers of fluorescent nanoparticles [35], lubricants [36, 37], chemosensors for metal ions [38], electrolyte solutions for energy storage devices [39, 40, 41], as gate dielectric layer for OFETs [42], or as polyelectrolytes [26, 43, 44].
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2.3.1. Anticancer, antibacterial reagents
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Several studies have been performed on cyclotriphosphazene-based protic molten salts (PMOSs) synthesized with cyclotriphosphazenes and bulky organic acids. Recently, aminocyclotriphosphazenes have received greater attention due to their anti-cancer agent properties [45, 46]. In contrast to cyclotriphosphazene derivatives, there are not many studies related to cyclotriphosphazene salts as antimicrobial and anticancer agents [31, 32, 33, 34]. Phosphazenium salts are very soluble in common apolar and polar organic solvents and some are quite soluble in water. Solubility in biological liquid is very important in pharmacological studies. Therefore, studies on the biological and anti-cancer activities of the salts of cyclotriphosphazenes are likely to attract great interest because of their organic solvent/water solubility and various PMOS diversity with different properties.
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Akbaş et al. prepared the salicylic acid salts (1–6) of pyrrolidine and piperidine substituted cyclotriphosphazenes (Figure 14). The crystallographic data of 5 clearly indicate that the nitrogen of the phosphazene ring was protonated (Figure 15). The antimicrobial and cytotoxic activities of the phosphazenium salts (1–6) were also investigated. Compounds 5 and 6 appear to be good candidates for anti-cancer agents because they have significant cytotoxic activity against DLD-1 cancer cells. All of the compounds have an antimicrobial effect on bacterial and yeast strains between 312 and 625 μM (bacterial strains) and 19.5–312 μM (yeast strains) and compounds 4–6 are found to be most effective against yeast strains [31].
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Figure 14.
Salicylic acid salts of the mono(4-fluorobenzyl)spirocyclotriphosphazenes.
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Figure 15.
The crystal structure of compound 5.
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Elmas et al. synthesized phosphazenium salts (1a-4a) from the reactions of the phosphazene bases (1–4) with gentisic acid (Figure 16). The crystallographic data of 4a unambiguously indicate that the nitrogen of the phosphazene ring is monoprotonated (Figure 17). Also, In vitro antimicrobial activities of compounds were investigated and the PILs (1a, 3a and 4a) were found to be significantly active against C. albicans [32].
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Figure 16.
The synthesis of 4-fluorobenzylspiro(N/O)cyclotriphosphazenium salts.
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Figure 17.
The crystal structure of compound 4a.
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Akbaş et al. obtained the PILs or PMOSs (1–3) from the reactions of [N3P3(NC4H8)6] with the gentisic, decanoic and boric acids (Figure 18). Their biological activity in cultured cell lines was investigated. The binding of 1,2 or 3 to calf thymus (CT-DNA) and bovine serum albumin (BSA) led to remarkable changes in spectral characteristics. The potent low cytotoxic, strong apoptotic, and effective DNA topoisomerase inhibitory characteristics of these PILs revealed that they can be a good candidate for anticancer drugs [33].
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Figure 18.
The syntheses of the PILs (1–3) with [N3P3(NC4H8)6] and gentisic, decanoic and boric acids, respectively.
\n
Okumuş et al. obtained the PMOSs from the reactions of tetrapyrrolidino- and tetrapiperidino-substituted cyclotriphosphazenes with the gentisic and γ-resorcylic acids (Figure 19). The crystallographic result of 1b and 2b exhibited that the N atom of the phosphazene ring adjacent to the spiro precursor was mono protonated (Figure 20). In addition, their cytotoxic and antiproliferative activities against A549, Hep3B and normal FL cell lines were investigated. The findings also displayed that the PMOS (1b-6b) were strong antiproliferatives and they had excusable cytotoxic activities against the cells [34].
\n
Figure 19.
The gentisic and γ-resorcylic acid salts of the tetrapyrrolidino and tetrapiperidino mono(4-fluorobenzyl)spirocyclotriphosphazenes.
\n
Figure 20.
The crystal structure of 1b and 2b.
\n
\n
\n
2.3.2. Adsorbents and surface modifiers of fluorescent nanoparticles
\n
Veldboer et al., quaternized the cyclotriphosphazenes having terminal tertiary amino functions with methyl iodide (Figure 21) and the resulting salts were studied as surface modifiers for lanthanide phosphate nanoparticles. It was observed that the quaternized cyclic phosphazenes were well suited for coupling to the nanocrystalline surface and a strategy for surface modification of cyclotriphosphazenes containing cationic substituents was developed. A good solubility of nanoparticles in an aqueous medium is a significant precondition for the prediction of bioanalytical applications such as fluorescent immunoassays. This is the main purpose of specially designed molecule surface modifiers. The stable nanocrystal-linker complexes in methanol were formed with compounds 3 and 4, while the fully quaternized cyclic phosphazenes 1 and 2 interact strongly with nanoparticles, resulting in an agglomeration. It was found that aromatic groups may interfere with the UV absorption in nanocrystals, but no significant effect of aliphatic side chains was observed [35].
\n
Figure 21.
The synthesis of cyclotriphosphazenium iodide salts.
\n
\n
\n
2.3.3. Lubricants
\n
Omotowa et al. investigated the tribological properties of PzILs containing trimethylammonium and N-methylpyridinium chains (Figure 22). (Dimethylamino)ethoxy, pyridylmethoxy, or (dimethylamino)propoxy side groups linked to the phosphorus in the phosphazene ring were quaternized at the side group nitrogen with iodomethane to obtain polyiodo salts. Subsequently, polyquaternary PZILs were formed with salts such as LiN(SO2CF3)2 or NaBF4 by the anions exchange reaction. These PzILs were investigated for use as lubricants for aircraft gas turbine engines and as additives in water lubrication of silicon nitride ceramics Friction and wear properties of water with 5–8 (0.25 weight %) as boundary lubricant additives were tested on silicon nitride ceramic interfaces. It was observed that these PzILs lead to a decrease in the running-in period. The PzILs, 5–8, are more viscous than the free cyclophosphazene bases and are highly viscous for use as oils. For a faster transition to low friction, ionic liquids with higher solubility must be used [36].
\n
Figure 22.
PzILs containing trimethylammonium and N-methylpyridinium chains.
\n
Recently, additives obtained from phosphazene having polar functions which can interact with tribological surfaces, have been developed. Singh et al. obtained The PzP(-NHP)6 salt with N3P3Cl6 and 2,6-di-tert-butyl-4-(dimethylaminomethyl) phenol (Figure 23). This compound contains a phosphazene ring containing polar nitrogen and phosphorus atoms surrounded by hindered phenolic substituents with tert-butyl groups. Due to these properties, it can show an affinity for a metal surface to form a surface film which leads to anticorrosion, antiwear, and antifriction properties together with antioxidant characteristics. Reportedly, the PzP(-NHP)6 additive exhibits excellent antioxidant properties, and moderate anticorrosion, antiwear and antifriction properties. A doping concentration of 3000 ppm PzP(-NHP)6 decreased the average wear scar diameter (AWSD) and average friction coefficient by 15.81% and ~27.27%, respectively, in comparison to those for the blank polyol base oil [37].
\n
Figure 23.
The structure of the PzP(-NHP)6 salt.
\n
\n
\n
2.3.4. Chemosensors for metal ions
\n
Çiftçi et al. obtained the quaternized cationic and zwitterionic derivatives of 3-[2-(diethylamino)ethyl]-7-oxy-4-methylcoumarin substituted trimeric and tetrameric derivatives with dimethyl sulfate and 1,3-propanesultone, respectively (Figure 24). Quaternized ionic and zwitterionic compounds display excellent solubility in water and the effects of metal ions on the fluorescent behavior of the cytophosphazene salts were investigated using these compounds as chemosensors for metal ions. The results showed that cyclophosphazenium salts exhibit highly selective fluorescence chemosensor behavior for Fe3+ ions in aqueous solution [38].
\n
Figure 24.
The quaternization of coumarin-substituted cyclophosphazene derivatives.
\n
\n
\n
2.3.5. Electrolyte solutions for energy storage devices
\n
The ionic liquid also serves as an ion source for the formation of an electric double layer when electrolytes are used for the electrical double layer capacitor. Thus, an additional supporting electrolyte is not required. The PzIL is decomposed during combustion to produce a nitrogen gas, a phosphate ester, and the like. Because of this nitrogen gas, phosphate ester and the like, the ionic compound overcomes the risk of low combustion. Further, when the ionic compound contains a halogen, the halogen acts as an active radical during the accidental combustion to reduce the risk of burning. Moreover, when the ionic compound contains an organic substituent, the oxygen has a protective effect, as it forms a carbide during combustion. When the ionic compound is in a liquid state at room temperature, it can be used as an electrolyte for an electric double layer capacitor, a lithium-ion battery or a dye-sensitized solar cell, a reaction solvent for an organic synthesis, an extracting solvent for an organic compound and a magnetic fluid. If the ionic compound is in a solid state at room temperature, it can be used as a salt. It exhibits high non-combustibility in both of the liquid and solid states and can significantly suppress the risk of combustion in the application. For this purpose, various PzILs have been synthesized (Figure 25) [39, 40, 41].
\n
Figure 25.
The conversion of chloropentafluorocyclotriphosphazenes to PzILs.
\n
\n
\n
2.3.6. A gate dielectric layer for OFETs
\n
Organic field effect transistors (OFETs) are very attractive with their potential applications in a wide area, as flexible and low cost electronic devices. Conventional electrolytes are not stable with their solvents and it is difficult to stabilize the electrolyte concentration. However, ionic liquids are attractive as a gate dielectric layer for OFETs with superior properties such as high thermal and chemical stability, non-volatility, non-toxicity and high polarizability. For this purpose, PzILs have been synthesized. The chain nitrogen atoms of free cyclotriphosphazene bases were quaternized by treatment with methyl iodide to give phosphazenium salts, PzIL1-PzIL4. Subsequently, polyquaternary PZILs have been formed with LiN(SO2CF3)2 (Figure 26). These PzILs have been used as the dielectric layer in OFETs. Due to the high dielectric effect of PzILs, the fabricated OFETs have operated in the low voltage ranges. On/off ratios of these OFETs are about 102. The low value of on–off ratio could be caused by the increasing thickness and doping level of active organic layer [42].
\n
Figure 26.
The chemical structure of mono(4-fluorobenzyl)cyclotriphosphazene ionic liquids.
\n
\n
\n
2.3.7. Polyelectrolytes
\n
Linear polyphosphazenes containing quaternary ammonium side groups have the potential for application as a polycation component in the formation of ordering polyelectrolyte multilayers. Polyelectrolyte multilayers comprise of ionically modified polyphosphazenes by layer-by-layer assembly of a cationic (PAZ+) and an anionic (PAZ−) polyphosphazene (Figure 27). The dc conductivity values of the PAZ+/PAZ− films were found to be ten times greater than those of the PAH/PSS multilayers when these multilayers were compared to those of poly(sodium-4-styrenesulfonate) (PSS) and poly(allylamine hydrochloride) (PAH) [43].
\n
Figure 27.
Structures of the (PAZ+) (2) and (PAZ−) (3) polyphosphazenes.
\n
Polyelectrolytes were obtained by quaternization of the poly- alkoxy- and aryloxy- phosphazenes with strong alkylating reagents (Figure 28). Because of the lower electron donating abilities of the alkoxy and aryloxy side groups compared to the alkylamino side groups, quaternization is only carried out with methyl trifluoromethanesulfonate (MeOTf). Quaternary poly(alkoxyphosphazenes) have a high ionic conductivity without the need for plasticizers or additional salts [26].
\n
Figure 28.
Quaternization of polymers.
\n
Because of the atomic polarization of the iodide anion, it has been found that the iodide salts (ionomer) of poly[bis(methoxyethoxyethoxy)phosphazene] (MEEP) (Figure 29) have a high frequency dielectric constant, ε∞ (highest value ε∞=11). These MEEP-based polyphosphazene salts have a room temperature dc conductivity of 10−6 S·cm−1. If the segmental mobility can be increased, they may have a potential for application in iodide conducting solar cells [44].
\n
Figure 29.
Synthetic route for the polyphosphazenes and their salts.
\n
\n
\n
\n
\n
3. Conclusions
\n
In this chapter, we reported a literature review about phosphazene-based ionic liquids (PzILs), which have received considerable attention in recent years. The design and synthesis of PzILs were introduced, and the recent applications (since 2004) were analyzed and discussed. We believe that further studies on the synthesis and application of new PzILs will be performed in the near future.
\n
\n\n',keywords:"phosphazene-based ionic liquid, biologically-active material, electrolyte, lubricant, catalyst",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/60922.pdf",chapterXML:"https://mts.intechopen.com/source/xml/60922.xml",downloadPdfUrl:"/chapter/pdf-download/60922",previewPdfUrl:"/chapter/pdf-preview/60922",totalDownloads:1162,totalViews:228,totalCrossrefCites:1,totalDimensionsCites:3,totalAltmetricsMentions:0,impactScore:1,impactScorePercentile:70,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"February 15th 2018",dateReviewed:"March 19th 2018",datePrePublished:"November 5th 2018",datePublished:"September 26th 2018",dateFinished:"April 21st 2018",readingETA:"0",abstract:"This chapter presents the definition, synthesis, and possible application of cyclo and polyphosphazene-based ionic liquids (PzILs). PZILs constitute an alternative class of phosphorus nitrogen compounds and their derivatives have been widely used in biologically-active materials, electrolytes, lubricants, catalysts or nanomaterials. Considerable information is available on substitution reactions taking place at the phosphorus atoms of poly and cyclophosphazenes, thus, a wide variety of phosphazene derivatives have been obtained. However, quaternization of ring nitrogen atoms has received less attention. In addition, phosphazenes containing aliphatic and aromatic substituents with terminal tertiary amino groups are synthesized and subsequently quaternized with methyl iodide. The successive metathesis with salts such as LiN(SO2CF3)2 or NaBF4 gives the respective PzILs. In the compounds identified as protonic ionic liquids (PILs) or protic molten salts (PMOSs), the positively charged position is determined by X-ray diffraction study. PzILs are also soluble in water and in many polar organic solvents.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/60922",risUrl:"/chapter/ris/60922",book:{id:"7230",slug:"recent-advances-in-ionic-liquids"},signatures:"Ahmet Karadağ and Hüseyin Akbaş",authors:[{id:"246024",title:"Prof.",name:"Ahmet",middleName:null,surname:"Karadağ",fullName:"Ahmet Karadağ",slug:"ahmet-karadag",email:"akaradag@bartin.edu.tr",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246024/images/7029_n.jpg",institution:{name:"Bartin University",institutionURL:null,country:{name:"Turkey"}}},{id:"249798",title:"Dr.",name:"Hüseyin",middleName:null,surname:"Akbaş",fullName:"Hüseyin Akbaş",slug:"huseyin-akbas",email:"huseyinakbas18@hotmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Phosphazene-based ionic liquids",level:"1"},{id:"sec_2_2",title:"2.1. Phosphazene-based ionic liquids in which quaternization occurs on the nitrogen atom or phosphorus atom of phosphazene",level:"2"},{id:"sec_3_2",title:"2.2. Phosphazene-based ionic liquids in which quaternization occurs on a pendant group of phosphazene bonded to a phosphorus atom",level:"2"},{id:"sec_4_2",title:"2.3. Applications of phosphazene-based ionic liquids",level:"2"},{id:"sec_4_3",title:"2.3.1. Anticancer, antibacterial reagents",level:"3"},{id:"sec_5_3",title:"2.3.2. Adsorbents and surface modifiers of fluorescent nanoparticles",level:"3"},{id:"sec_6_3",title:"2.3.3. Lubricants",level:"3"},{id:"sec_7_3",title:"2.3.4. Chemosensors for metal ions",level:"3"},{id:"sec_8_3",title:"2.3.5. Electrolyte solutions for energy storage devices",level:"3"},{id:"sec_9_3",title:"2.3.6. A gate dielectric layer for OFETs",level:"3"},{id:"sec_10_3",title:"2.3.7. Polyelectrolytes",level:"3"},{id:"sec_13",title:"3. 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Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups. Journal of Molecular Structure. 2015;1087:1-10. DOI: 10.1016/j.molstruc.2015.01.033\n'},{id:"B46",body:'Akbaş H, Okumuş A, Kılıç Z, Hökelek T, Süzen Y, Koç LY, Açık L, Çelik ZB. Phosphorus-nitrogen compounds part 27. Syntheses, structural characterizations, antimicrobial and cytotoxic activities, and DNA interactions of new phosphazenes bearing secondary amino and pendant (4-fluorobenzyl)spiro groups. European Journal of Medicinal Chemistry. 2013;70:294-307. DOI: 10.1016/j.ejmech.2013.09.046\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Ahmet Karadağ",address:"ahmet.karadag@gop.edu.tr",affiliation:'
Department of Biotechnology, Bartın University, Turkey
Department of Chemistry, Gaziosmanpaşa University, Turkey
Department of Chemistry, Gaziosmanpaşa University, Turkey
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1. Introduction
The leather sector is regarded in most African countries as a major economy driver that highly contributes to a country’s economic growth by means of employment opportunities and foreign cash inflow. The leather sector includes tannery, footwear, leather gloves, and leather goods and garment subsectors. Leather by itself requires high care during the different phases of production, storage, and transportation. Hence, the issue of quality in leather manufacturing process is of paramount importance as most defects in leather and leather products are irreversible. Rework or correction of incurred damages during production of leather, leather goods, and garment leads to higher labor costs and sometimes to rejection of the products. Therefore, the implementation of quality control (QC) concepts in every production step is associated with a valuable impact on the finished products so that defect-free products reach end users.
Most of the Ethiopian companies specializing in the leather sector prefer visual inspections and simpler physical testing methods to control product quality. This preference may work for the local market as the latter may not draw too much focus on quality aspects due to it being less aware for various quality dimensions. However, for penetrating and competing on an international level, special privileges such as African Growth Opportunity Act (AGOA) from importing countries or producing goods with the required quality and at a competitive price are required. Nonetheless, consistent with descriptive statistics results, econometric findings also reveal that exporting firms were found rather less efficient compared to those which are either powerless or have totally given up looking for the international market with respect to income and market sustainability. Once basic international standards are met and market access is established through various mechanisms including participation in trade fairs, the use of the internet, and buyer contacts, exporting companies have continued to benefit from the market due to the natural superiority of Ethiopian leather in terms of fineness, thickness, flexibility, strength, and compactness of texture, according to UNCTAD (2000) [1].
But this is not true for export markets. All leather and leather products-related quality standards need to be implemented which in turn includes, but may not be limited to, physical and/or chemical testing and inspections. In a perfectly competitive market setup consisting of a high number of buyers and sellers (also referred to as a thick market), price signals would reward high quality, and hence, producers and traders of substandard quality would either be driven out of the market or would be relegated to a distinct low-quality-oriented market [2].
This chapter provides a background on quality control aspects for the production of leather products that directly reach end users. It covers quality control aspects applicable to leather products and goods and the garment manufacturing subsector.
1.1 Aims and objectives
The objective of this chapter is to provide a background on quality control aspects required in the production of leather products. In doing so, this research work aims to address the significance of quality control and quality aspects in the leather products manufacturing subsector.
2. Literature review
Quality is an absolute term. Concepts of quality and quality control with regard to the manufacture of leather goods and garments need to be viewed in accordance with the policies of the relevant specialty industries. The outcome thereof in conjunction with the application of quality control concepts listed herein will serve as the basis for supervisors, team leaders, and even operators in those companies with advanced know-how to the parameters, check points, and control mechanisms so that defect-free products will reach end users.
Most Ethiopian leather and leather products manufacturing firms had implemented various quality-related improvement tools and systems including, ISO 9001:2018, Environmental Management Systems (EMS ISO 14001:2018, Occupational Health and Safety Management Systems ISO 45001:2018), and a plethora of other quality management systems (QMSs) in order to enhance their local and global competitions. For instance, (ELICO) Ethiopian Leather Industries Company PLC, Pittards Glove Manufacturing Factory PLC, Modern Zege leather products and footwear Industry PLC had implemented these systems [3].
Therefore, they will be able to acquire and maintain quality concepts, agreed quality standards and procedures, and introduce quality control/quality assurance (QA) to organizational staff/personnel. Furthermore, they will apply these parameters in leather goods and garment production, identify accompanied issues, and provide related documents to employees in accordance with the organization policy.
To implement quality standards, the basic conditions of the customer are (a) the purpose and (b) the selling price of the product or service.
These basic conditions can be resolved in to the following 10 detailed conditions:
specifications of dimensions,
operating characteristics,
life and reliability objectives,
safety requirements,
relevant standard,
engineering,
manufacturing and quality costs,
production conditions,
field installation,
maintenance and service objectives,
energy utilization and material conservation factors,
environmental and other side effects, and
cost of operation or use
2.1 Concept of quality
Quality is the totality of features and characteristics of a product or service that affect its ability to satisfy the specified or implied needs of a customer. Quality consistency requires from users to concentrate on the process rather than on the product alone. Quality gurus define quality as “conformance to requirement” and “fitness for use” [4]. Good quality will automatically result in productivity improvement. It is the author’s view that the best policy should be to do the things right first time.
Quality helps determine a firm’s success in a number of ways:
customer loyalty: satisfied customers return, make repeat purchases, and recommend the product or service to others,
strong brand reputation for quality: retailers want to stock the product; improved quality leads to fewer returns and replacements which in turn lead to reduced costs attracting thus and retaining good staff.
The term “Quality” can be measured aspects such as failure or reject rates, level of product returns, customer complaints, customer satisfaction, customer loyalty, evident from repeat purchases, or renewal rates and employee health and well-being.
2.2 Quality parameters
Quality is measured in a relative manner. It depends on how the user perceives or the way he/she get satisfied with that product/service. Once a product/service is accepted to customers, it can pull more new customers and may be produced/delivered in greater numbers, affecting in turn costs that are reduced and sales which will be increased. But, as quality has no universal meaning, the way users perceive it varies. Some users may like the performance or the reliability, while others may be happy with esthetic features and so on. What is reliable for a user may not be true for another. Hence, quality is an important factor which customers look for in a product or service in order to be rewarded with total satisfaction. Some of the important quality factors/parameters that customer considers in a product or services as stated by some quality gurus are listed as follows.
2.2.1 Dimensions (parameters) of quality
Performance: it evaluates if the product does the intended (planed or proposed) job or if the service delivered meets intended objective. Potential costumers usually evaluate a product to determine if it will perform certain specific functions and how well it will do them. For example, the production of a document holder or a leather bag with multifunction pockets would fall within this category.
Reliability: it indicates a product’s failure rate. Different products may need repair over their service life. The leather machineries should be also reliable so as to increase productivity, i.e. when leather garments are produced, greater attention ought to be placed during, e.g. the stitching procedure. As the needle is typically of a cutter edge type, sometimes it stitches the component by cutting the part. So, if proper stitching is not done, the product is either repaired or rejected.
Durability: it shows the duration that the product is expected to last for. This is the effective service life of the product that customer wants over a long period of time, e.g. a customer that orders a leather jacket may expect this to last for at least 5 years.
Serviceability: this parameter stands for how easy the product may be repaired. There are many industries where the customer’s view of quality is directly influenced by how quickly and economically a repair or routine maintenance activity can be accomplished’ in this case-study, dyeing or changing color of the leather jacket after a number of uses can be an example for this.
Esthetics: this dimension shows what the product looks like externally. This is the visual appeal of the product, often taking into account factors such as style, color, shape, packaging alternatives, and other sensory features.
Features: it means what features the product possesses. Usually, customers associate high quality with products that have added features (such as special color, design, handles, and decorations), which go beyond the basic performance of the competition.
Conformance: it is used to evaluate if the product or service conforms to the specification. This means, if it is developed based on a performance specification; will it actually perform as specified? If it is developed based on a design specification, does it possess all of the features defined?
Perceived quality: The product or service may possess adequate or even superior dimensions of quality but still fall victim to negative customer or public perceptions. As an example, a high-quality product may get the reputation for being low quality based on poor service by installation or field technicians. If the product is not installed or maintained properly, and fails as a result, the failure is often associated with the product’s quality rather than the quality of the service it receives.
2.3 Quality control and quality assurance
Quality control (QC) is a procedure or a set of procedures intended to ensure that a manufactured product or performed service adheres to a defined set of quality criteria or meets the requirements of the client or customer. While quality assurance (QA) is defined as a procedure or set of procedures projected to ensure that a product or service under development (before the work is complete, as opposed to afterward) meets specified requirements. QA is sometimes expressed together with QC as a single expression. There is plenty of quality control types. The following are used in the leather-related production controls [5].
Quality control of incoming material:
Ensuring the right materials are available in the right quantity at the right time.
Based on quality requirements, the purchase information such as specification, packing instruction, and transportation instruction should be clearly identified.
For example, in the garment industry for finished leather, the parameters such as color fastness, light fastness, tensile strength and softness need to be checked.
Physical characteristics such as lining, tensile strength and color fastness need to be checked. After finalizing the parameters to be assessed for each incoming material, the standards need to be met for each parameter of each incoming material.
Process control:
Process control (PC) can be defined as any activity that adds value to the product to be supplied or the service to be rendered. The term “process” in the leather garments manufacturing industry may include – but not be limited to – unit processes such as cutting, assembling and stitching, and finishing. According to the process control steps, the parameters for each process need to be identified first. For example, in assembling and stitching, the needle to be used, i.e. the needle number and needle point have an influence on the final product. Further, the thread used in bobbin (lower thread) and the sewing machine (top thread) also affects the quality of the final product.
Process control is carried out by the following steps:
Identification of process control parameters,
Establishing the standards for each parameter of each process (internal process control standard/working standard for process control),
Product refers to the physical output produced by supplying in the inputs or raw materials and carrying out any production process. The final product is what is dispatched to the customer or the end users. Apart from this, there are components sometimes referred to as intermittent products. For a leather garment manufacturer, these are prepared sleeves, pockets, collars, etc. Therefore, the output after each operation or process is an intermediate product. Product control generally refers to the control of the final product. Control of intermediate products is equally essential. This is due to the fact that in each stage the product quality is ensured so as to produce the final product of desired quality [6].
2.4 Quality inspection and testing
Quality inspection: Industrial activities which ensure that manufactured products, individual components, and multicomponent systems are adequate for their intended purpose. Whereas inspection is the activity of examining the product or its components to determine if they meet the design standards, testing is a procedure in which the item is observed during operation in order to determine whether it functions properly for a reasonable period of time under given stress conditions. Inspection and testing are performed before, during, and after manufacturing to ensure that the quality level of the product is within acceptable design standards.
There are also various types of inspections. The following categories are used in leather goods and garment production:
Incoming materials inspections: checking the quantity (finished leather, accessories, etc.), quality, rejection allowances, verification as per purchase order, lead time, etc.
First-article inspections: QC inspects first-article samples prior to volume production. This verifies that product specifications are being met and avoids unnecessary re-engineering work later.
In-process inspections: these on-site inspections evaluate samples of the products selected during the manufacturing process. This confirms the quality of the product and allows any necessary changes to be addressed early on reducing, hence, rework time and costs.
Pre-shipment inspections: during a pre-shipment inspection, engineers verify that finished goods conform to set specifications.
Sample inspections: samples are taken from inspection lots for end user evaluation, laboratory testing, or customer approval randomly, and processing QC can help for inspection. After this type of inspection, one can offer rapid service at a very affordable rate.
International standards are preferred to be used for testing leather products, especially in the garment industry. Table 1 shows this standard.
No.
Items
Standard
1
Elastic tapes
IS 9686
2
Metal buckles
IS 96986:1980
3
Threads
IS 1376/1803
4
Leather garment sizing system
IS 10397
5
Metallic slide fastener
IS 3148:1983
6
Garment quality guide
IS 12675
7
Leather for garments
IS 12718
8
Fur leather
IS 3840/2961
9
Fusible lining
IS 12806
10
Zip fasteners
IS 8894/3184/4829
Table 1.
Standards related to leather garments industry and related items.
Source: Leather Industry Development Institute, Advanced Garment Production, Level IV Training Materials, June 11, 2016.
3. Results and analysis
3.1 Leather goods common quality parameters
In addition to the eight quality parameters of any product like durability, feature, performance, conformity, esthetics, serviceability, perceived quality, and reliability, there are also other leather goods-specific quality parameters.
3.2 Most commonly used types of testing
Leather testing: it includes wet rub fastness, dry rub fastness, tool test, stress strain test, and plaster test fastness.
Leather goods and garments testing: it encompasses handbags and small luggage, wherein the strength – say – of strap fastenings is an important consideration in the quality assessment of handbags and luggage. A large number of companies in Ethiopia are able to carry out all strength tests utilizing state-of-the-art equipment to assess the risk of strap failures, whether at fastenings (e.g. buckles) or where the strap is attached to the body of the item itself. The other one is the leather belt testing, from an assessment of the components of a belt for labeling purposes. Also, specialty companies can perform further tests in order to satisfy all clients’ requirements such as the color fastness (wet and dry rub fastness test) to tarnishing of buckles and metal components, to ensure the products are fit for the purpose they are intended for.
A few examples of tests used in leather products manufacturing firms are as follows:
Smell test: the smell test is an important part of every inspection. To avoid illegal toxins, the most reliable way to check it is to perform chemical tests as per ASTM D1296 in an accredited Leather Industry Development Institute (LIDI) laboratory.
Function test: the objective is to check if the product works as designed or anticipated. In the case of the leather bag, an inspector will wear it and test the zippers’ direction and strength.
Color fastness check on leather: excessive dye may be rubbed off during a color fastness check. On leather, this is a frequent problem. The test may be repeated 10 times with a dry cloth and 10 times with a wet cloth.
Abuse and fatigue tests: pulling on straps and zippers with stronger-than-usual force helps to understand the manufacturing quality of leather bags.
Seam strength test for leather bags: this test is similar to the abuse test but focuses on the seams. It uses a tension gauge to check seam strength.
Load test: the inspector loads the leather bag with weights (depending on the model between 2 and 20 kg for backpacks (bag type) most of the time. Then the bag is lifted at least 20 times and is hanged on a hook for 4 h. This is an internal company policy similar to that of color fastness check.
Zipper twisting test: this type of test is used to check both the strength of the zipper and the seams holding it in the open middle and closed position. The QC pulls the zipper sideways for 10 s in each direction. Low-quality zippers tend to open and bend beyond repair. Extensive laboratory equipment test products (e.g. opening and closing zippers 5000 times) could be used also. However, most of small and medium leather products manufacturing companies use the manual test.
Carton humidity check: This test is performed in order to assess the behavior of the product in rainy conditions, while avoiding the buildup of mold or fungus, aiming at maintaining a humidity level below 12%. In particular, during the rainy season, the inspector should check the humidity of the export cartons with a humidity tester. As such, it ought to be ensured that sufficient desiccant (calcium oxide absorb water) is placed in the right spots.
3.3 Factors that influence the quality of leather goods and garments
Factors that influence quality aspects make bags and garments good and/or cheap. The following aspects are commonly experienced in leather products manufacture:
3.3.1 Designs and materials
The design room is where quality starts in leather goods manufacturing companies. Bag design is a system, which is not only the combination of the technique, knowledge, and the art, but also the connection of design and craft from the choice of the theme to grasp the inspiration and the accomplishment of the finished product. Through the design effect of a product, a bag or a garment should become a bridge between designers, technicians, and consumers. In that sense, it would be common language among them. The designers should identify the materials like type of leathers, accessories, colors, and hardware that will be used in the production process. A well-designed bag or a garment should include all information about its design. As an example, a good leather goods design should have at least the following information:
leather type (color, thickness, and feeling),
origin (cow, sheep, goat, buffalo, etc.)
reinforcement (EVA sheet, water proof, fusing, foam, etc.),
lining (velvet, cotton fabric, nylon, and polyester),
accessories (eyelet and rivet),
zipper, in terms of size (3, 5, and 8 mm), finishing (silver, gold, and bronze), and type (metallic, plastic chain, and plastic molded),
stitching (seam type and seam length per centimeter),
thread size (for needle thread and bobbin thread), type (cotton, nylon, polyester, silk, and polyester spun cotton), each dimension, (volume, height, and base, handling length, and width),
edge finishing (raw edge, folded, and edge color) and hard ware’s (buckle, color, and adjustable size) [7].
3.3.2 Material selection
Material selection refers to the materials selected for the manufacture of – say – a bag including the hardware and the accessories, as well as the processes involved.
3.3.3 Pattern making and cutting
The pattern making, which is also referred to as a sample making process is an important aspect and is regarded as a bridge of transforming the graphic designs into the products. The maximum permissible error (acceptable level) of pattern is 1/32 inches (1 inch error of 32 inches length), as by reference to any bag, or in accordance with international standards, such as SATRASumm, which is an industry standard package concerning the efficient cutting of leather and synthetic materials. In pattern making, usually major parts (shape and size of the bag) are made first, and then relatively smaller parts are followed and so on.
3.3.3.1 Fixing product size standards
Unlike leather garment and foot wear products, leather bags have no fixed specifications such as height, depth, and width and may therefore be easy to categorize as small bags, medium bags, and large bags. One could remember Galileo Galilei’s quote: “Measure what can be measured, and make measurable what cannot be measured.” From a quality management point of view, this means that “we cannot manage what we cannot measure.” In short, the clearer the specification, the better the possibility of creating and delivering quality products.
3.3.3.2 Construction
Construction is the matter of how everything or patterns have been put together. Figure 2 shows pattern alignment variations.
Figure 2.
Pattern alignment variations: (a) and (b).
3.3.3.3 Technology
The manufacturing process is a key factor to leather products’ quality. A different technology represents a different style of leather products. The quality of bags is as good as the people that make it. That is why the best stitchery, leather workers, and quality control technician or experts are required. In order to have best-quality products and workers, it is important to put a lot of resources into training or hiring the most qualified staff and paying them well fostering their commitment and creative minds.
3.4 Defects in goods and garments manufacturing
3.4.1 Defects and their types
Defects are deviations/nonconformities of processes, products, or materials from the requirements/standards. Causes of defects may be man-made (assignable causes) or common/natural causes. Assignable causes can be removed, while common causes can only be reduced. For example, a poorly build knife maybe a cause for cutting defects/human fault, while loose leather is a cause for less durability of the garments.
3.4.2 Methods of identifying and isolating faulty pieces
Defects in the cutting section can be identified by various bodies operating therein that are briefly presented as follows:
Cutting supervisors: they are the cutting supervisors that issue leather from raw material store where defects like loose leather, under substance, wrong color/shape, poor nap on nubuck, poor color fastness, and poor knife can be visually identified, and the leather is thereafter sorted accordingly. Only leather bundles that meet specifications are issued and allocated among cutting operators by the supervisors.
Cutting operators: they can identify during cutting minor defects like grains not matched pair wise, wrong direction of cutting, cuts/flaws in component, open defect, wrong size cut, and color variations to name but a few. These operators, in addition to cutting operations, have the responsibility to take care of component quality. As such, items ought to be cut in line with the parameters stated earlier and the data be posted to the operators.
Defects in the stitching (sewing) section can be identified by various bodies operating therein.
Bench workers can identify defects like notch marks not matched, edge folding inaccurate, improper alignment, wrong components placement, too much hammering, and too much glue.
Stitching operators: they can identify minor defects like uneven stitching length, skipped stitches, stitches not locked at the end, wrong needle/thread used, stitches too far or too close to the edge, stitches not as per the marking, broken stitches, top tension tight, and seam puckering.
Possible defects during the final inspection stage may be:
trimming,
thread burning,
glue erasing,
leaving uneven stitching length,
pattern vs. assembly correspondence,
measurement and alignment,
grain structure checking,
component checking,
color and size matching,
ironing dimension,
seem puckering,
proper feeding system,
thread tension,
leaving broken stitches and skipped stitches,
stitches too far or too close to the edge,
top tension tight, thickness, and not ±0.2 mm allowances [8].
3.5 Part five: Finishing in leather products manufacturing
Finishing is the final process given to a garment or goods in order to achieve good appearance, desirable feel and look and to impart some important, and durable and functional properties.
3.5.1 Classification of finishing
Finishing in leather products manufacturing can be classified according to the nature of the finish such as Kawabata’s Evaluation System for Fabric-KES-FB and the degree of performance (ISO11644:2009). Figure 3a and b show these classifications.
Figure 3.
Classifications based on (a) the nature of finish (KES-FB) and (b) the degree of performances as per ISO11644:2009.
3.5.2 Edge coloring
Sand edges: this is done by using emery paper to sand the edges and to arrange many belts/straps of the same size side by side on a flat table and sand simultaneously. This will ensure that all the leather layers are even and square and that any residual glues or finishes have been removed. Figure 4 shows edge coloring in industry.
Figure 4.
Edge coloring in practical.
Applying color: this is done either by using a machine or manually. For manual operation, the use of dye box like Fiebing’s dye will make it simpler. Keeping the dyed edge by facing up for air-drying before applying on the opposite edge is worthy. After the other side got dried, one can paint the opposite one and keep the same way one has done previously. It can also be applied during the second round if necessary. This method is used everywhere globally even though manual coloring is preferably practical in Ethiopian leather products manufacturing firms. Figure 5 indicates the application of color with the aid of a machine.
Figure 5.
Applying color with machine.
Applying filler: the leather filler paste is a white compound that can be air- or heat-dried and requires re-coloring with a leather repair pigment after its application. The leather filler remains flexible, durable, and natural to the existing leather surface. It is used to fill the edge surface and results in smoothness to the edge’s surface (see Figure 6).
Figure 6.
Leather filler paste.
Wet and soap: the edge of the leather can be wetted using a sponge or piece of trimmed woolskin. The outcome will be a slick/polished rounded edge.
Burnishing: this is accomplished by briskly rubbing the canvas against the edge of the belt until the edge is smooth. A canvas wrapped around a motorized wood burnishing wheel which speeds up the process could be used herein. However, care should be taken not to over-burnish, which will result in a rough edge.
Hand burnishing: this is done by means of a clean cloth that rubs the edges removing hence, any residual dye and determining thus, if the second coat is necessary.
Polish: at this point, paraffin is applied to the edge of the belt and burnished again and again. Denim works well here if burnishing is done by hand. Once one is satisfied with the finish, one can polish to a high luster with a dry cloth [9].
Finish: after the edges are polished, final finish is applied.
3.5.3 Trimming: Hand trimming and trimmer machine
It is preferred to use thread trimmer machines as it reduces trimming costs, increases production, uses unskilled help, eliminates scissor damage, keeps trimming area clean, and reduces cleanup cost. One can choose between different clipper blades and motor control for diverse material. Scissors can be used for trimming (Figure 7).
Figure 7.
Scissors for trimming.
Thread burning: it can be manual with a candle or by means of soldering iron (Figure 8).
Figure 8.
Soldering iron used for thread burning.
4. Discussion
The quality control concept is very useful especially for exports of branded products. Apart from the general knowledge and experience of the author in the sector, secondary sources were used from institutions such as the Ethiopian Leather Industry Development Institute (LIDI), Ethiopian Leather Industry Associations, and medium- and large-scale leather products manufacturers. The LIDI laboratory was accredited from SANAS (South African National Accredited System) so as to support the leather sector with various laboratory testing (i.e. physical, mechanical, and chemical) services in 2012. Furthermore, the LIDI laboratory was also accredited from the Ethiopian National Accreditation Office (ENAO) in the same year.
With this responsibility, LIDI has been serving Ethiopian leather manufacturing firms by laboratory testing, technical training, quality management system (QMS), and quality control and quality assurance tools implementations. Under the Twinning program, which was made between LIDI and the Federal Democratic Republic of Ethiopia, FDRE, Ministry of Industry on Ethiopian side, and CSIR – Central Leather Research Institute-Council of Scientific and Industrial Research, India, in association with Footwear Design and Development Institute (FDDI), India, LIDI’s R&D laboratory state of the art was created to meet the requirements and demands of leather and leather products in order to meet and ensure international quality standards [10].
Most of leather goods and garment manufacturing companies in Ethiopia use smell test, function test, and color fastness check on leather accepting it as internal company policy, as it matches with some of global/international standards in this aspect (ASTM D1296, ISO 11640, ISO 11641, SLF 401, IUP 470).
Apart from common quality parameters, there are also other leather goods-specific quality parameters. Items made from real leather or imitations, such as PU, which are very popular, should be treated accordingly. However, leather goods and garment manufacturing companies prefer to use simpler (by observation and manual tests) methods, whereas other manufacturers in footwear subsectors could use more test methods as per international standards in order to check, for example, grain structure, thickness, apparent density, shrinkage, flex resistance, water resistance, and so on as per ISO 2589:2002, ISO 2420, ISO 5402, ISO 3380, ISO 5403. That is because, footwear products are highly vulnerable to damage, and hence, their suitability to use needs to be assured before reaching the end users. Table 2 provides a summary of physical testing standards for leather that could be recommended by the author to be used so as to improve productivity and reduce defect rates, rework, and waste.
S.No.
Types of test
Test method
1
Determination of thickness
ISO 2589:2002
2
Determination of apparent density
ISO 2420
3
Determination of tensile strength and percentage elongation
ISO 3376
4
Determination of tearing load (single and double)
SO3377---1/3377---2
5
Determination of distension and strength of grain ball burst
ISO 3378
6
Determination of flex resistance by flexometer method
ISO 5402
7
Determination of shrinkage temperature up to 1150°C
ISO 3380
8
Water absorption (Kubelka) after 2 and 24 h
SATRA TM/ISO SLP 19
9
Determination of water resistance test for light leather
ISO 5403
10
Determination of water resistance of heavy leather
ISO 5404
11
Determination of water vapor permeability
ISO 14268
12
Determination of cold crack resistance leather finish
SLP 34
13
Determination of sole/upper adhesion tester
Internal
14
Measurement of shoe flex (walk meter)
Internal
15
Determination of dry heat resistance of leather
Internal
16
Determination of adhesion of leather finish
SLF 11
17
Color fastness to artificial light (xenon)
SLF 401
18
Determination of fastness to water spotting
ISO 11642
19
Color fastness to perspiration
ISO 11641
20
Determination of fastness of leather finish to (to and from rubbing)
ISO 11640
21
Determination of fastness to ironing (fastness to heat)
IUP 470
22
Determination of static water absorption
ISO 2417
Table 2.
Leather physical testing.
Source: Leather Industry Development Institute’s Physical Laboratory, March 23, 2016.
Regarding the effect of human factors in product quality, it is the author’s view that most quality problems are caused primarily by a lack of interest or care on the part of the worker in the production department. However, it is usually not only the worker who is responsible for this but also the conditions necessary to carry out the work correctly often do not exist. For example, instructions may be inadequate, the incoming material may be defective, the machines may not be capable of producing goods of the required quality, and proper conditions for conducting inspection of the product are not given to the workers, and so on. The study done by joint consultancy of Ethio-Indian twinning project in collaboration with the Leather Industry Development Institute (LIDI) and the Footwear Design and Development Institute (FDDI) of India approves this fact [11]. Figure 4 (in Section 4.1) shows that inadequate instructions, which accounts for about 28% caused the rest effects. Effective understanding of the worker to the instructions in every step of production will surely lead to more pleasant effects on the product quality. However, although workers may not have control over these factors, they may though lead to defective work. Figure 9 shows Pareto analyses of one factory.
Figure 9.
Result of Pareto analysis for ELICO-universal leather products unit. Source: Twinning report [11].
In Japan, it is generally believed that 40% of quality problems are caused by poor product design, 30% of quality problems are due to wrong or defective materials being purchased from suppliers, and the remaining 30% are due to errors made during the manufacturing process [12]. One could argue that any other quality problems in manufacturing are caused in equal proportion by managers (by not providing adequate training for workers) and by workers (by not paying adequate attention to machine settings).
Regarding defects observed in goods and in garments manufacturing listed in the following section are common examples of deficiencies in leather products manufactured in Ethiopia:
Sewing defects: open seams, wrong stitching techniques, non-matching threads and missing stitches, improper creasing of the garment, erroneous thread tension and raw edges are some of the sewing defects which can affect the garment quality adversely. Firms mitigate these types of defects by providing continuous on-the-job trainings for sewing operators.
Color defects: this category includes color variations between the sample and the final garment, wrong color combinations, and mismatching dyes’ that should always be avoided. Leather issuers check this in store for every order with the help of leather sorter or in-process quality inspector.
Sizing defects: this refers to wrong gradation of sizes and difference in the measurement of various parts of garment-like sleeves of XL size for a body of L size garment that can deteriorate the garments beyond repair. Though tanneries use leather grading machine during production, Ethiopian leather goods and garment manufacturing firms usually identify and mitigate these defects by cross-checking cut components visually.
Other defects: this group entails broken or defective buttons, snaps, stitches, different shades within the same garment, dropped stitches, exposed notches and raw edges, fabric defects, holes, faulty zippers, loose or hanging sewing threads, misaligned buttons and holes, missing buttons, needle cuts or chews, pulled or loose yarn, stains, unfinished buttonhole, short zippers, inappropriate trimmings, etc. These defects, unless tackled at the very beginning, and/or quality assurance is undertaken in every step, could lead leather products manufacturing companies to be less competitive and affect in turn their existence. Due to globalization and acceptance of Ethiopian leather products to export markets, manufacturers of leather products are obliged to implement various quality improvement tools including QC/QA. Thus, respective process and final quality checking parameters have been posted in front of operators in each section along with visual defective and free cut components. This method encourages operators to think about quality issues in addition to their duties of – say – cutting, table work, sewing, and finishing.
Concerning defect control at the finishing section, various final quality control parameters are used that include trimming, thread burning, glue erasing, pattern vs. assembly correspondence, thread tension, leaving broken stitches and skipped stitches, and stitches too far or too close to the edge.
As for Ethiopian leather products manufacturers, the defect control parameters during the final inspection stage include aspects such as:
leaving uneven stitching length,
measurement and alignment,
grain structure checking,
component checking,
color and size matching,
ironing dimension,
seem puckering,
proper feeding system,
top tension tight and thickness, etc., are inspected prior to this stage.
5. Conclusion and further work
The leather sector’s contribution is very high with respect to export incomes and economic development, especially on creating job opportunities. For instance, according to the Central Statistical Agency (CSA) of Ethiopia, export of leather and leather products, which was US $23 million in 2013, reached US$133 million in 2018. Hence, leather goods and garment to be exported need high care during all manufacturing stages in order to increase competitiveness in the global market.
This book chapter discussed quality control concepts and quality standards for leather goods and garment. In doing so, it highlighted applicable procedures and documents enabling supervisors, quality controllers, and operators in those companies to get detailed knowledge about quality parameters and control mechanisms so that defect-free products reach end users. Furthermore, it will allow readers to familiarize themselves with quality concepts in this sector. It is the author’s view that this research work may prompt readers to confront themselves with quality control aspects and to research more about these aspects in this specialized manufacturing area.
Moreover, leather goods and garment quality parameters and factors that influence the quality of leather goods and garment were included. In addition to the earlier-mentioned ones, commonly occurring defects, methods of identifying and isolating faulty pieces, and some finishing types in leather products production were discussed.
Studying the application of QC/QA on the whole leather sector (leather processing, footwear industry, glove making, and other related subsectors) will be the next tasks of the researchers and book writers. This may include subsector-specific inspection and control mechanisms starting from designing, cutting, table work (preparation), sewing, inspection and testing, packing, and shipping that need to be further analyzed.
Acknowledgments
The author would like to express his gratitude to his wife for her patience and assistance.
Further reading
To get more practical explanation of quality aspects, readers are advised to read of the work of David Garvin (1988) – Eight Dimensions of Quality.
\n',keywords:"quality, quality control, leather goods and garment, defects",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/82033.pdf",chapterXML:"https://mts.intechopen.com/source/xml/82033.xml",downloadPdfUrl:"/chapter/pdf-download/82033",previewPdfUrl:"/chapter/pdf-preview/82033",totalDownloads:6,totalViews:0,totalCrossrefCites:0,dateSubmitted:"January 15th 2022",dateReviewed:"March 14th 2022",datePrePublished:"May 30th 2022",datePublished:null,dateFinished:"May 30th 2022",readingETA:"0",abstract:"The leather industry is one of the priority sectors that contribute to export income and economic development in the majority of African countries, in terms of creating job opportunities. Leather products need high care during manufacturing because their quality should never be compromised. Quality is a universal term used to evaluate the performance of a product or a service and the acceptance by the customer(s) in terms of customer satisfaction. As such, understanding quality concepts such as quality control (QC), quality standards, procedures, and documents related to leather goods and garment production in accordance with manufacturing company’s policy is deemed useful within the context of this paper. Supervisors, quality controllers, and operators in leather products manufacturing firms need to know required quality parameters and associated control mechanisms so that defect-free products will reach the end users. In order to achieve this, quality-influencing parameters such as performance, reliability, durability, serviceability, esthetics, features, and conformance are measured so as to verify set quality levels. Furthermore, factors that affect the quality of leather goods and garments as well as methods of identifying and isolating common defects and faulty pieces especially in the finishing activities of leather production are included herein. Hence, this paper covers quality control aspects on leather goods observed within the garment manufacturing subsector.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/82033",risUrl:"/chapter/ris/82033",signatures:"Abduletif Hebo",book:{id:"11170",type:"book",title:"Quality Control",subtitle:null,fullTitle:"Quality Control",slug:null,publishedDate:null,bookSignature:"Dr. Leo Dimitrios Kounis",coverURL:"https://cdn.intechopen.com/books/images_new/11170.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-991-9",printIsbn:"978-1-80355-990-2",pdfIsbn:"978-1-80355-992-6",isAvailableForWebshopOrdering:!0,editors:[{id:"111582",title:"Dr.",name:"Leo",middleName:"Dimitrios",surname:"Kounis",slug:"leo-kounis",fullName:"Leo Kounis"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 Aims and objectives",level:"2"},{id:"sec_3",title:"2. Literature review",level:"1"},{id:"sec_3_2",title:"2.1 Concept of quality",level:"2"},{id:"sec_4_2",title:"2.2 Quality parameters",level:"2"},{id:"sec_4_3",title:"2.2.1 Dimensions (parameters) of quality",level:"3"},{id:"sec_6_2",title:"2.3 Quality control and quality assurance",level:"2"},{id:"sec_7_2",title:"2.4 Quality inspection and testing",level:"2"},{id:"sec_9",title:"3. Results and analysis",level:"1"},{id:"sec_9_2",title:"3.1 Leather goods common quality parameters",level:"2"},{id:"sec_10_2",title:"3.2 Most commonly used types of testing",level:"2"},{id:"sec_11_2",title:"3.3 Factors that influence the quality of leather goods and garments",level:"2"},{id:"sec_11_3",title:"3.3.1 Designs and materials",level:"3"},{id:"sec_12_3",title:"3.3.2 Material selection",level:"3"},{id:"sec_13_3",title:"3.3.3 Pattern making and cutting",level:"3"},{id:"sec_13_4",title:"3.3.3.1 Fixing product size standards",level:"4"},{id:"sec_14_4",title:"3.3.3.2 Construction",level:"4"},{id:"sec_15_4",title:"3.3.3.3 Technology",level:"4"},{id:"sec_18_2",title:"3.4 Defects in goods and garments manufacturing",level:"2"},{id:"sec_18_3",title:"3.4.1 Defects and their types",level:"3"},{id:"sec_19_3",title:"3.4.2 Methods of identifying and isolating faulty pieces",level:"3"},{id:"sec_21_2",title:"3.5 Part five: Finishing in leather products manufacturing",level:"2"},{id:"sec_21_3",title:"3.5.1 Classification of finishing",level:"3"},{id:"sec_22_3",title:"3.5.2 Edge coloring",level:"3"},{id:"sec_23_3",title:"3.5.3 Trimming: Hand trimming and trimmer machine",level:"3"},{id:"sec_26",title:"4. Discussion",level:"1"},{id:"sec_27",title:"5. Conclusion and further work",level:"1"},{id:"sec_28",title:"Acknowledgments",level:"1"},{id:"sec_28",title:"Further reading",level:"1"}],chapterReferences:[{id:"B1",body:'Worku G, UNCTAD. Is the Ethiopian leather industry on the right track? An empirical investigation. Ethiopian Journal of Economics. 2000, 2001;X(2):16'},{id:"B2",body:'Girum A, Florian S. High Hopes and Limited Successes: Experimenting with Industrial Polices in the Leather Industry in Ethiopia. Working Papers. Addis Ababa: Ethiopian Development Research Institute; 2014'},{id:"B3",body:'Annual Leather Sector Performance Report for LIDI. Addis Ababa, Ethiopia: Leather Industry Development Institute; 15 October 2019'},{id:"B4",body:'Juran JM, Blanton GA. Juran’s Quality Handbook. 5th ed. New York: McGraw Hill; 1998. pp. 20-28'},{id:"B5",body:'Alemu T. Leather Goods Design, Manufacturing & Quality Book. Maude Avenue, Sunnyvale, USA: LAP LAMBERT Academic Publishing; 2018. pp. 46-58'},{id:"B6",body:'Application of Quality Standards, College Level-III Training Material. 2019. pp. 15-39. Available from: https://www.elidi.com [Accessed: 2021-06-12]'},{id:"B7",body:'The innovative garment accessories. Available from: https://www.fibre2fashion.com/industry-article [Accessed: 2021-05-10]'},{id:"B8",body:'Engineer’s Manual No. E356-01. p. 23'},{id:"B9",body:'Mechanical finishing, polishing vs. buffing by Pat Wenino. Available from: https://www.pfonline.com [Accessed: 21 September 2021]'},{id:"B10",body:'Leather Industry Development Institute. Compendium of Outcome and Achievements of Twinning Program, 2011-2014. September 16th, 2014'},{id:"B11",body:'Twinning Project. Unpublished Company Report. ELICO Universal Leather Products Factory. 2014'},{id:"B12",body:'Product Quality, A Guide for Small and Medium-Sized Enterprises. Working Paper. Vienna: United Nations Industrial Development Organization; 2006'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Abduletif Hebo",address:"abduinda@gmail.com",affiliation:'
Bio and Emerging Technology Institute, Emerging Technology Center, Reverse Engineering Directorate, Addis Ababa, Ethiopia
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As discovery of human miRNAs increased in the setting of disease, the research focus was gradually shifted towards miRNA therapeutic strategy for diagnostic and treatment of disease. Increasing evidences suggest that miRNAs are the next important class of antisense therapeutic molecules, which have significant advantage over antisense such as siRNAs because miRNAs are naturally occurring endogenous molecules. Aberrant alteration of the endogenous miRNAs has been linked to the development of certain diseases. Correcting these altered miRNAs by their mimics or inhibitors has been developed as potential therapeutic approaches. Some of the miRNA-based therapeutics are processed in preclinical and clinical trial for treatment hepatitis C, liver cancer, and other diseases. Currently, the major focus in the development of miRNA-based therapeutics is how to increase the miRNA stability and optimize delivery systems for specific disease with minimal off-target effect. 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Then, we discuss the miRNA-based potential therapeutic approaches and implication in disease.",book:{id:"6987",slug:"antisense-therapy",title:"Antisense Therapy",fullTitle:"Antisense Therapy"},signatures:"Andrew Walayat, Meizi Yang and DaLiao Xiao",authors:[{id:"188957",title:"Dr.",name:"DaLiao",middleName:null,surname:"Xiao",slug:"daliao-xiao",fullName:"DaLiao Xiao"},{id:"269866",title:"Ph.D. Student",name:"Andrew",middleName:null,surname:"Walayat",slug:"andrew-walayat",fullName:"Andrew Walayat"},{id:"283826",title:"Dr.",name:"Meizi",middleName:null,surname:"Yang",slug:"meizi-yang",fullName:"Meizi Yang"}]},{id:"32799",doi:"10.5772/33525",title:"GC3 Biology in Eukaryotes and Prokaryotes",slug:"gc3-biology-in-eukaryotes-and-prokaryotes",totalDownloads:1982,totalCrossrefCites:7,totalDimensionsCites:15,abstract:null,book:{id:"1723",slug:"dna-methylation-from-genomics-to-technology",title:"DNA Methylation",fullTitle:"DNA Methylation - From Genomics to Technology"},signatures:"Eran Elhaik and Tatiana Tatarinova",authors:[{id:"95992",title:"Dr.",name:"Tatiana",middleName:"Valerievna",surname:"Tatarinova",slug:"tatiana-tatarinova",fullName:"Tatiana Tatarinova"},{id:"105570",title:"Dr.",name:"Eran",middleName:null,surname:"Elhaik",slug:"eran-elhaik",fullName:"Eran Elhaik"}]},{id:"63488",doi:"10.5772/intechopen.80874",title:"Nontransformative Strategies for RNAi in Crop Protection",slug:"nontransformative-strategies-for-rnai-in-crop-protection",totalDownloads:2050,totalCrossrefCites:5,totalDimensionsCites:13,abstract:"RNAi in crop protection can be achieved not only by plant-incorporated protectants through plant transformation (transgenic) but also by nontransformative strategies such as formulations of sprayable dsRNAs used as direct control agents, resistance factor repressors, or developmental disruptors. Therefore, the RNAi-based biopesticides are expected to reach the market also in the form of nontransgenic strategies such as sprayable products, stem injection, root drenching, seed treatment, or powder/granule. While the delivery of dsRNA by transgenic expression is well established, it requires generations of crop plants and is costly, which may take years and delays for practical application, depending on the regulatory rules, plant transformability, genetic stability, and public acceptance of genetically modified crop species. DsRNA delivery as a nontransgenic approach was already published as a proof-of-concept work, so it is time to point out some directions on how the real potential for agriculture and crop protection is.",book:{id:"7331",slug:"modulating-gene-expression-abridging-the-rnai-and-crispr-cas9-technologies",title:"Modulating Gene Expression",fullTitle:"Modulating Gene Expression - Abridging the RNAi and CRISPR-Cas9 Technologies"},signatures:"Deise Cagliari, Ericmar Avila dos Santos, Naymã Dias, Guy Smagghe\nand Moises Zotti",authors:null},{id:"65775",doi:"10.5772/intechopen.84628",title:"The Role of DNA Repair in Cellular Aging Process",slug:"the-role-of-dna-repair-in-cellular-aging-process",totalDownloads:1274,totalCrossrefCites:3,totalDimensionsCites:11,abstract:"Aging is defined as the time-dependent decline of functional properties. One common denominator of aging is mitochondrial dysfunction and accumulation of genetic damage throughout life. In fact, the imperfect maintenance of nuclear and mitochondrial DNA likely represents a critical contributor of aging. Each day, the integrity and stability of DNA are challenged by exogenous physical, chemical, or biological agents, as well as by endogenous processes, including DNA replication mistakes, spontaneous hydrolytic reactions, and reactive oxygen species. In this way, DNA repair systems have evolved a complex network that is collectively able of dealing with most of the damages inflicted. However, their efficiency may decrease with age and, therefore, influence the rate of aging. Thus, the purpose of this work is to summarize the recent knowledge in cellular aging process and its link with DNA repair systems, with a particular emphasis on the molecular mechanisms associated.",book:{id:"8605",slug:"dna-repair-an-update",title:"DNA Repair",fullTitle:"DNA Repair- An Update"},signatures:"Francisco Alejandro Lagunas-Rangel and Rosa María Bermúdez-Cruz",authors:[{id:"205238",title:"Dr.",name:"Rosa",middleName:null,surname:"Bermudez",slug:"rosa-bermudez",fullName:"Rosa Bermudez"},{id:"287111",title:"MSc.",name:"Francisco-Alejandro",middleName:null,surname:"Lagunas-Rangel",slug:"francisco-alejandro-lagunas-rangel",fullName:"Francisco-Alejandro Lagunas-Rangel"}]}],mostDownloadedChaptersLast30Days:[{id:"66368",title:"Introductory Chapter: Gene Editing Technologies and Applications",slug:"introductory-chapter-gene-editing-technologies-and-applications",totalDownloads:1152,totalCrossrefCites:0,totalDimensionsCites:3,abstract:null,book:{id:"8891",slug:"gene-editing-technologies-and-applications",title:"Gene Editing",fullTitle:"Gene Editing - Technologies and Applications"},signatures:"Yuan-Chuan Chen",authors:[{id:"185559",title:"Dr.",name:"Yuan-Chuan",middleName:null,surname:"Chen",slug:"yuan-chuan-chen",fullName:"Yuan-Chuan Chen"}]},{id:"64290",title:"Strand Displacement Amplification for Multiplex Detection of Nucleic Acids",slug:"strand-displacement-amplification-for-multiplex-detection-of-nucleic-acids",totalDownloads:2177,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"The identification of various targets such as bacteria, viruses, and other cells remains a prerequisite for point-of-care diagnostics and biotechnological applications. Nucleic acids, as encoding information for all forms of life, are excellent biomarkers for detecting pathogens, hereditary diseases, and cancers. To date, many techniques have been developed to detect nucleic acids. However, most of them are based on polymerase chain reaction (PCR) technology. These methods are sensitive and robust, but they require expensive instruments and trained personnel. DNA strand displacement amplification is carried out under isothermal conditions and therefore does not need expensive instruments. It is simple, fast, sensitive, specific, and inexpensive. In this chapter, we introduce the principles, methods, and updated applications of DNA strand displacement technology in the detection of infectious diseases. We also discuss how robust, sensitive, and specific nucleic acid detection could be obtained when combined with the novel CRISPR/Cas system.",book:{id:"7331",slug:"modulating-gene-expression-abridging-the-rnai-and-crispr-cas9-technologies",title:"Modulating Gene Expression",fullTitle:"Modulating Gene Expression - Abridging the RNAi and CRISPR-Cas9 Technologies"},signatures:"Lingwen Zeng, Omar Mukama, Xuewen Lu, Shilin Cao and Donghai\nLin",authors:null},{id:"63557",title:"Molecular Identification of Genetically Modified Crops for Biosafety and Legitimacy of Transgenes",slug:"molecular-identification-of-genetically-modified-crops-for-biosafety-and-legitimacy-of-transgenes",totalDownloads:1993,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Crops undergo artificially DNA modifications for improvements are considered as genetically modified (GM) crops. These modifications could be in indigenous DNA or by introduction of foreign DNA as transgenes. There are 29 different crops and fruit trees in 42 countries, which have been successfully modified for various traits like herbicide tolerance, insect/pest resistance, disease resistance and quality improvement. GM crops are grown worldwide and its area is significantly increasing every year. Many countries have very strict rules and regulations for GM crops and are also a trade barrier in some situations. Hence, identification and testing of crops for GM contents is important for identity and legitimacy of transgene to simplify the international trade. Normally, molecular identification is performed at three different levels, i.e., DNA, RNA and protein, and each level has its own importance in testing about the nature and type of GM crops. In this chapter, current scenario of GM crops and different molecular testing tools are described in brief.",book:{id:"8891",slug:"gene-editing-technologies-and-applications",title:"Gene Editing",fullTitle:"Gene Editing - Technologies and Applications"},signatures:"Shahid Nazir, Muhammad Zaffar Iqbal and Sajid-ur-Rahman",authors:null},{id:"38872",title:"Repetitive DNA: A Tool to Explore Animal Genomes/Transcriptomes",slug:"repetitive-dna-a-tool-to-explore-animal-genomes-transcriptomes",totalDownloads:4690,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"2748",slug:"functional-genomics",title:"Functional Genomics",fullTitle:"Functional Genomics"},signatures:"Deepali Pathak and Sher Ali",authors:[{id:"33032",title:"Dr.",name:"Sher",middleName:null,surname:"Ali",slug:"sher-ali",fullName:"Sher Ali"},{id:"141455",title:"Dr.",name:"Deepali",middleName:null,surname:"Pathak",slug:"deepali-pathak",fullName:"Deepali Pathak"}]},{id:"64492",title:"Antisense Oligonucleotides, A Novel Developing Targeting Therapy",slug:"antisense-oligonucleotides-a-novel-developing-targeting-therapy",totalDownloads:3371,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"Antisense oligonucleotides (ASOs) have been validated as therapeutic agents and an important tool in molecular biology. Indeed, ASOs are used either in vitro or in vivo to generate mRNA selective knockouts. They can be used for human therapy since ASOs can inhibit specifically target genes especially whose are difficult to target with small molecules inhibitors or neutralizing antibodies. However, despite their specificity and broadness of use, some practical obstacles remain unsolved in antisense pharmacology, such as insufficient stability due to nucleases degradation activity, and poor cellular delivery as a result of low cellular uptake difficult biological membrane crossing. Moreover, in many cases, potential off-target effects and immunostimulation are also part of the problems derived from their use. In this review, we will discuss ASOs, their chemistry, limitation of use, some solutions to increase stability, and finally some of their therapeutical application.",book:{id:"6987",slug:"antisense-therapy",title:"Antisense Therapy",fullTitle:"Antisense Therapy"},signatures:"Sara Karaki, Clément Paris and Palma Rocchi",authors:[{id:"273516",title:"Dr.",name:"Palma",middleName:null,surname:"Rocchi",slug:"palma-rocchi",fullName:"Palma Rocchi"},{id:"275051",title:"Dr.",name:"Sara",middleName:null,surname:"Karaki",slug:"sara-karaki",fullName:"Sara Karaki"},{id:"282578",title:"Dr.",name:"Clement",middleName:null,surname:"Paris",slug:"clement-paris",fullName:"Clement Paris"}]}],onlineFirstChaptersFilter:{topicId:"396",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81708",title:"High Throughput Methods to Transfer DNA in Cells and Perspectives",slug:"high-throughput-methods-to-transfer-dna-in-cells-and-perspectives",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.104542",abstract:"Genome sequencing led to thousands of genes to study and their molecular cloning to provide ORF collection plasmids. The main approach to study their function involves analysis of the biological consequences of their expression or knockdown, in a cellular context. Given that, the starting point of such experiments is the delivery of the exogenous material, including plasmid DNA in cells. During the last decades, efforts were made to develop efficient methods and protocols to achieve this goal. The present chapter will first give a rapid overview of the main DNA transfer methods described so far: physical, chemical, and biological. Secondly, it will focus on the different methods having reached high-throughput nowadays. Finally, it will discuss the perspectives of this field in terms of future enhancements.",book:{id:"11356",title:"Molecular Cloning",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg"},signatures:"Colin Béatrice and Couturier Cyril"},{id:"81720",title:"Genetic Transformation in Prokaryotic and Eukaryotic Cells",slug:"genetic-transformation-in-prokaryotic-and-eukaryotic-cells",totalDownloads:27,totalDimensionsCites:0,doi:"10.5772/intechopen.103839",abstract:"Improving the quality and quantity of an organism and its products can be approached by molecular characters enhancement through the insertion of a gene of interest into cells of the desired organism. Genetic transformation of an organism involves isolation, identification, cloning a gene of interest into a vector, and transferring the gene to the target organism. This chapter reviews the process of genetic transformation into the organism’s cell from bacterial (Escherichia coli), yeast, plant (Onion, Tobacco, and Orchids), and mammalian. The discussion will be focused on the introduction of DNA molecules into plant cells and protoplast mediated by polyethylene glycol (PEG), electroporation, and gene gun using particle bombardment. Further discussion on the transient protein expression system of plant-based on protoplast, onion cell, and tobacco will also be covered in this chapter as well. The systems have been proven as a powerful tool for determining subcellular protein localization, protein-protein interactions, identifying gene function, and regulation. Finally, it can be clearly seen, the differences and similarities in the mechanism of genetic transformation both in prokaryotic and eukaryotic systems.",book:{id:"11356",title:"Molecular Cloning",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg"},signatures:"Endang Semiarti, Yekti Asih Purwestri, Saifur Rohman and Wahyu Aristyaning Putri"},{id:"81604",title:"Nonribosomal Peptide Synthesis",slug:"nonribosomal-peptide-synthesis",totalDownloads:29,totalDimensionsCites:0,doi:"10.5772/intechopen.104722",abstract:"Nonribosomal peptides (NRPs) are a type of secondary metabolite with a wide range of pharmacological and biological activities including cytostatics, immunosuppressants or anticancer agents, antibiotics, pigments, siderophores, toxins. NRPs, unlike other proteins, are synthesized on huge nonribosomal peptide synthetase (NRPS) enzyme complexes that are not dependent on ribosomal machinery. Bacteria and fungi are the most common NRPs producers. Furthermore, the presence of these peptides has been confirmed in marine microbes. Nowadays, many of these peptides are used in the treatments of inflammatory, cancer, neurodegenerative disorders, and infectious disease for the development of new therapeutic agents. The structure, function, and synthesis of NRPs, as well as producer microorganisms and their several application areas, are covered in this chapter.",book:{id:"11356",title:"Molecular Cloning",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg"},signatures:"Sadık Dincer, Hatice Aysun Mercimek Takci and Melis Sumengen Ozdenefe"},{id:"81051",title:"CRISPR Technology: Emerging Tools of Genome Editing and Protein Detection",slug:"crispr-technology-emerging-tools-of-genome-editing-and-protein-detection",totalDownloads:28,totalDimensionsCites:0,doi:"10.5772/intechopen.102516",abstract:"CRISPR technology has seen rapid development in applications ranging from genomic and epigenetic changes to protein identification throughout the last decade. The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) protein systems have transformed the ability to edit, control the genomic nucleic acid and non-nucleic acid target such as detection of proteins. CRISPR/Cas systems are RNA-guided endonucleases exhibiting distinct cleavage activities deployed in the development of analytical techniques. Apart from genome editing technology, CRISPR/Cas has also been incorporated in amplified detection of proteins, transcriptional modulation, cancer biomarkers, and rapid detection of POC (point of care) diagnostics for various diseases such as Covid-19. Current protein detection methods incorporate sophisticated instrumentation and extensive sensing procedures with less reliable, quantitative, and sensitive detection of proteins. The precision and sensitivity brought in by CRISPR-dependent detection of proteins will ensure the elimination of current impediments. CRISPR-based amplification strategies have been used for accurate estimation of proteins including aptamer-based assay, femtomolar detection of proteins in living cells, immunoassays, and isothermal proximal assay for high throughput. The chapter will provide a comprehensive summary of key developments in emerging tools of genome editing and protein detection deploying CRISPR technology, and its future perspectives will be discussed.",book:{id:"11356",title:"Molecular Cloning",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg"},signatures:"Rita Lakkakul and Pradip Hirapure"},{id:"80374",title:"Viral Vectors in Gene Therapy and Clinical Applications",slug:"viral-vectors-in-gene-therapy-and-clinical-applications",totalDownloads:33,totalDimensionsCites:0,doi:"10.5772/intechopen.102559",abstract:"Developments in gene therapy, coupled with advances in genome sequencing and a greater understanding of DNA sequences, have given rise to an exciting area of research. The use of viral vectors in gene therapy has become a very promising and fast-emerging technology over the past few decades. Despite previous setbacks, the approval of viral vector therapies worldwide, with many in late-stage clinical trials has led to a significant increase in research in this area of gene therapy. Retroviral, adenoviral, adeno-associated viral, and lentiviral vectors are all key vectors currently being researched and used in clinical trials. There are many challenges with the use of viral vectors that are yet to be overcome including cost of production, the immune response, and the ability to precisely regulate the expression of the transgene. However, with increased numbers of clinical trials showing efficacy, safety, and growing financial investment, the future use of viral vectors in gene therapy is increasingly promising.",book:{id:"11356",title:"Molecular Cloning",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg"},signatures:"Alexandra L.G. Mahoney, Najah T. Nassif, Bronwyn A. O’Brien and Ann M. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"June 11th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. 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In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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