Victor David

University of Bucharest

Professor Victor David graduated from the Faculty of Chemistry, Bucharest, Romania. Between 2007 and 2019 he was the head of the Analytical Chemistry Department at the University of Bucharest, where he is now Emeritus Professor. His main field of research is separation science (theory and applications). His list of publications includes six books for Elsevier and ten for Romanian publishing houses, 12 chapters in books and encyclopedias, and 150 papers in ISI journals. From 2017‒2020 he was Associate Editor of the Journal of Liquid Chromatography and Related Technologies. Now he is a member of the editorial boards of Biomedical Chromatography, Molecules, Journal of Chemistry, Journal of Essential Oil-Bearing Plants, and Revue Roumaine de Chimie. He is co-editor of Analytical Liquid Chromatography – New Perspectives (IntechOpen, 2022).

5chapters authored

Chapters authored

Derivatization Methods in GC and GC/MS

By Serban C. Moldoveanu and Victor David

The first part of this chapter presents the main objectives for performing derivatization of a sample to be analyzed by gas chromatography (GC) or gas chromatography/mass spectrometry (GC/MS). The derivatization is typically done to change the analyte properties for a better separation and also for enhancing the method sensitivity. In GC/MS, derivatization may improve the capability of compound identification. Examples illustrating such improvements are included. The second part describes several types of derivatization that are more frequently used in analytical practice. These include alkylation (e.g., methylation), formation of aryl derivatives, silylation (e.g., formation of trimethylsilyl derivatives), acylation (e.g., reactions with acyl chlorides or with chloroformates), and several other types of derivatizations. The chapter also presents typical derivatizations for analytes with specific functional groups and discusses artifact formation in certain derivatization reactions.

Part of the book: Gas Chromatography

Ionic Liquids in Liquid Chromatography

By Victor David and Serban C. Moldoveanu

Ionic liquids (ILs) are salts of organic cations that are present in liquid state. They can be used as alternative to organic solvents for various analytical processes such as extracting solvents in sample preparation, or as mobile phase or components of the mobile phase in high performance liquid chromatography (HPLC). Also they can be used as stationary phase in gas chromatography (GC), or attached to a solid support as stationary phase in HPLC. Ils are typically more environmentally-friendly solvents than the classic organic solvents having low volatility, flammability and toxicity. The chapter presents various applications of ILs in liquid chromatography.

Part of the book: Analytical Liquid Chromatography

Progress in Technology of the Chromatographic Columns in HPLC

By Serban C. Moldoveanu and Victor David

Chromatographic column is an essential part of a any HPLC separation, and significant progress has been made in developing columns with better performance to provide better separation, a shorter separation time, resilience to a wider pH range of the mobile phase, longer lifetime, use of lower volumes of mobile phase, etc. All these characteristics were achieved by the introduction of novel technologies and improvements of the older ones. These include smaller particle used to fill the column, more homogeneous spherical particles, core-shell particles, monolithic columns, more pure silica as a stationary phase support, use of ethylene bridge silica, a wider variety of active phases, use of mixed mode stationary phases, use of polymers as stationary phase, use of various endcapping techniques, etc. Miniaturization and progress in the instrumentation played an important role for the chromatographic column development. All these aspects are summarized in the present chapter.

Part of the book: Analytical Liquid Chromatography

Recent Applications of Gas Chromatography in Bioanalysis

By Victor David and Serban C. Moldoveanu

Bioanalysis involves a broad range of chemical analyzes. These analyzes include that of biotics, such as natural components of living organisms, as well as xenobiotics, such as drugs and their metabolites in biological systems. Because many biotics and xenobiotics are not volatile molecules, the main technique for bioanalysis is high-performance liquid chromatography (HPLC) and the limitation of GC utilization is caused by the fact that GC is applicable only to volatile samples. However, gas chromatography (GC) in particular coupled with mass spectrometry (MS) as detection is also a very useful technique in bioanalysis. A considerable number of analytes in bioanalysis are volatile or can be made volatile following, for example, derivatization. As a result, GC (and GC/MS) are commonly utilized for the analysis of biotics, such as amino acids, fatty acids, various metabolites in biological fluids, and in particular of a large number of xenobiotics, such as drugs, drug metabolites, toxicants, and certain metabolic compounds caused by toxicants. The chapter will present progress in the GC methodology for extending its applicability to bioanalysis and will provide a review of more recent applications.

Part of the book: Novel Aspects of Gas Chromatography and Chemometrics

Introductory Chapter: Novel Aspects in Gas Chromatography and Chemometrics

By Vu Dang Hoang, Victor David and Serban C. Moldoveanu

Part of the book: Novel Aspects of Gas Chromatography and Chemometrics

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