The measurement and monitoring of shoreline changes are of great interest to coastal managers and engineers. Shoreline change information can be crucial for the assessment of coastal disasters, design of coastal infrastructure and protection of coastal environment. This chapter presents shoreline change monitoring based on multispectral satellite imagery and sub-pixel technique. Firstly, a brief introduction of shoreline definitions and indicators is given. Sub-pixel techniques for shoreline mapping on multispectral satellite images are then introduced. Following that, a brief review of existing research studies of long-term shoreline change monitoring based on multispectral imagery is given. Subsequently, a case study of sub-pixel shoreline change monitoring at the northern Gold Coast on the east coast of Australia is presented. By comparing the longshore averaged beach widths at seven representative transects from Landsat with those from Argus imaging data, the RMSEs range from 9.1 to 12.3 m and the correlations are all no less than 0.7. Annual means and variabilities of beach widths were estimated without significant differences from the reference data for most of the results. Finally, conclusions and recommendations for future work are given.