\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"345",leadTitle:null,fullTitle:"Diabetes Insipidus",title:"Diabetes Insipidus",subtitle:null,reviewType:"peer-reviewed",abstract:"The first chapter of the book reports on the management of Langerhans cell histiocytosis (LCH)-induced central diabetes insipidus and its associated endocrinological/neurological sequelae in the national survey. The next chapter addresses DI and head injuries. Next, the management of neuroendocrine instability during maintenance of potential organ donors is described. Organ transplants have gradually increased worldwide. To have maintenance of appropriate potential organs, AVP is needed. Furthermore, nephrogenic DI-the potential therapeutic drugs and analysis of membrane protein stability is the topic of the next two chapters, followed by new insights into the diagnosis and management of pregnancy-related DI. The seventh chapter reports on the problems with differential diagnosis in a case of central DI in a female patient with bipolar disorder. The lithium treatment usually resulted in nephrogenic DI. Finally, over the last years, the development of MRI imaging on the pituitary gland with the stalk and hypothalamus has advanced. The final chapter interprets imaging techniques in DI in detail.",isbn:null,printIsbn:"978-953-307-367-5",pdfIsbn:"978-953-51-6571-2",doi:"10.5772/860",price:119,priceEur:129,priceUsd:155,slug:"diabetes-insipidus",numberOfPages:150,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"00c5b8482c0640f8c06640cdcbfce8e1",bookSignature:"Kyuzi Kamoi",publishedDate:"November 14th 2011",coverURL:"https://cdn.intechopen.com/books/images_new/345.jpg",numberOfDownloads:33690,numberOfWosCitations:5,numberOfCrossrefCitations:5,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:9,numberOfDimensionsCitationsByBook:1,hasAltmetrics:0,numberOfTotalCitations:19,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 10th 2010",dateEndSecondStepPublish:"December 8th 2010",dateEndThirdStepPublish:"April 14th 2011",dateEndFourthStepPublish:"May 14th 2011",dateEndFifthStepPublish:"July 13th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"42483",title:"Prof.",name:"Kyuzi",middleName:null,surname:"Kamoi",slug:"kyuzi-kamoi",fullName:"Kyuzi Kamoi",profilePictureURL:"https://mts.intechopen.com/storage/users/42483/images/3674_n.jpg",biography:"Prof. Kyuzi Kamoi was born August 28, 1943 in Tokyo, Japan. He received his MD in 1970 and his MSD in 1982, both from the Medical School of Niigata University, Niigata, Japan.\nHe has received the following certificates: Japan Medical Diplomat (1970), Japan Board of Diabetes Mellitus (1990), Japan Board of Endocrinology and Metabolism (1991), Certified Diabetes Mellitus Educator (1993), Certified Endocrine Educator (2004).\nFrom 1980 to 2010 he was Chief of Internal Medicine, and from 2002 until 2010 the Director of Center of Diabetes Mellitus and Endocrine Disease at Nagaoka Red Cross Hospital, Japan. Since 2010 to the present he has been Professor of Niigata Prefecture University.\nHe is a member of The Japanese Society of Internal Medicine, The Japan Endocrine Society, The Japanese Society of Hypertension, The Japan Society of Hypertension, the Endocrine Society, The American Society of Hypertension, The American Diabetes Association, The International Diabetes Federation and the New York Academy of Science. 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MDS are a group of age-associated heterogeneous malignant bone marrow stem cell disorders. MDS are characterized by ineffective hematopoiesis, which leads to refractory cytopenias and to clonal instability. Patients with MDS have myeloid dysplasia, intramedullary apoptosis and an increased risk of transformation to acute myeloid leukemia (AML). The use of next generation sequencing has allowed for the identification of molecular mutations in several genes in about 90% of MDS patients. Several mutations will likely be incorporated into future prognostic scoring systems for MDS. About 50% of MDS cases are characterized by the presence of cytogenetic abnormalities. The correct morphological and cytogenetic analysis interpretation plays an important role in diagnosis and prognosis of these disorders. Cell death and an inflammatory gene signature are associated with MDS. Better understanding of the genetic and molecular mechanisms of MDS pathogenesis provides an opportunity for new treatment strategies to be developed. Promising novel therapies targeting pathophysiological mechanisms of MDS are being studied but the drugs currently used in MDS therapy remain limited. The only curative therapy for MDS is allogeneic hematopoietic stem cell transplantation. Recent advances in strategies to minimize transplant-related toxicity make this treatment possible for more MDS patients who are sufficiently fit.",isbn:"978-1-78985-478-7",printIsbn:"978-1-78985-477-0",pdfIsbn:"978-1-83962-040-9",doi:"10.5772/intechopen.73936",price:119,priceEur:129,priceUsd:155,slug:"recent-developments-in-myelodysplastic-syndromes",numberOfPages:120,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"f25aae5d062706d31025b1b21bb1d072",bookSignature:"Ota Fuchs",publishedDate:"February 20th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7138.jpg",keywords:null,numberOfDownloads:9138,numberOfWosCitations:0,numberOfCrossrefCitations:1,numberOfDimensionsCitations:2,numberOfTotalCitations:3,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 14th 2018",dateEndSecondStepPublish:"August 14th 2018",dateEndThirdStepPublish:"October 13th 2018",dateEndFourthStepPublish:"January 1st 2019",dateEndFifthStepPublish:"March 2nd 2019",remainingDaysToSecondStep:"4 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"36468",title:"Dr.",name:"Ota",middleName:null,surname:"Fuchs",slug:"ota-fuchs",fullName:"Ota Fuchs",profilePictureURL:"https://mts.intechopen.com/storage/users/36468/images/system/36468.jpeg",biography:"Ota Fuchs graduated from the Chemical Technological University, Prague, Czech Republic, in 1971. He obtained his Ph.D. in Biochemistry from the Faculty of Natural Sciences, Charles University, Prague, in 1981. He is employed as a Senior Scientist at the Institute of Hematology and Blood Transfusion, Prague. He undertook as visiting scientist short-term affiliations at the Beatson Institute for Cancer Research, Glasgow, UK; Institute of Experimental Medicine of the Russian Academy of Medical Sciences in St Peterburg, Russia; and Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada. Dr. Fuchs was the principal investigator of five projects of the Internal Grant Agency of the Ministry of Health of the Czech Republic and one grant project of the Grant Agency of Czech Republic.",institutionString:"Institute of Hematology and Blood Transfusion",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"4",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1026",title:"Hematological Oncology",slug:"hematological-oncology"}],chapters:[{id:"65408",title:"Introductory Chapter: Progress in Myelodysplastic Syndrome Area",slug:"introductory-chapter-progress-in-myelodysplastic-syndrome-area",totalDownloads:1025,totalCrossrefCites:0,authors:[{id:"36468",title:"Dr.",name:"Ota",surname:"Fuchs",slug:"ota-fuchs",fullName:"Ota Fuchs"}]},{id:"64871",title:"Diagnosis and Classification of Myelodysplastic Syndrome",slug:"diagnosis-and-classification-of-myelodysplastic-syndrome",totalDownloads:3172,totalCrossrefCites:0,authors:[{id:"36487",title:"Prof.",name:"Gamal",surname:"Abdul Hamid",slug:"gamal-abdul-hamid",fullName:"Gamal Abdul Hamid"},{id:"273724",title:"Dr.",name:"Safa",surname:"Shukry",slug:"safa-shukry",fullName:"Safa Shukry"},{id:"277511",title:"Dr.",name:"Abdulwahab",surname:"Al-Nehmi",slug:"abdulwahab-al-nehmi",fullName:"Abdulwahab Al-Nehmi"}]},{id:"63270",title:"Myelodysplastic Syndrome and Autoimmune Disorders: Causal Relationship or Coincidence?",slug:"myelodysplastic-syndrome-and-autoimmune-disorders-causal-relationship-or-coincidence-",totalDownloads:1200,totalCrossrefCites:0,authors:[{id:"253996",title:"Dr.",name:"Kam A.",surname:"Newman",slug:"kam-a.-newman",fullName:"Kam A. 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Annually several million people suffer bone fractures caused by accidents or diseases. Many of those fractures are too complex for an external medical treatment but have to be surgically fixated by internal bone implants. Traditional methods of osteosynthesis or osteotomy use permanent metal implants e.g. bone screws and bone plates made of steel or titanium alloys, but permanent metal implants have to be excised. Especially young patients in growth require the implant removal. Usually, metal implants should be removed latest one or two years after the first surgery. Biodegradable implants, which dissolve in the human organism, therefore represent an appropriate solution. Here magnesium as a degradable implant material provides both biocompatibility and sufficient mechanical properties. Studies have shown that magnesium, which is an essential element of the human organism, is suitable as a degradable biomaterial for use in medical implants. Also in relation to biomechanical requirements the suitability of magnesium as an implant material in has already been proven. Due to mechanical properties superior to the bone, magnesium implants show biomechanical properties comparable to conventional steel implants in standardized biomechanical tests. Also an influence of surface properties on the degradation behavior is already known. Interdisciplinary research between medical and engineering sciences focuses on the development of degradable magnesium implants for osteosynthesis. The removal of those implants after convalescence of the fractured bone is no longer necessary, resulting in a considerable benefit for patients and the public health care system.
\n\t\t\tThe aim is to preset individual degradation kinetics for implants made of biocompatible magnesium alloys through adjusting surface and subsurface properties of the magnesium implants for specific indications. Adapted machining processes exhibit possibilities to adjust those properties. The idea of implants specifically adapted to their desired function and functional period within a possible range of surface or subsurface modifications is illustrated schematically in Figure 1for different implant designs (V1 and V2). The healing process of a bone is illustrated schematically and opposed to the expected corresponding degradation process of a resorbable implant. Furthermore, possible processes for mechanical machining of the workpieces and modification of the surface and subsurface are illustrated. By means of these processes specific surface and subsurface properties can be adjusted, which, depending on the alloy, can achieve the modification bandwidth illustrated in Figure 1. By means of this modification bandwidth an implantation behavior of the implants during the production process can be achieved specific for each indication.
\n\t\t\tScheme of implants adapted to function and applicable machining processes
To adjust specific implant properties, the influence of the mechanical processing on surface and subsurface layers on selected biocompatible magnesium alloys has to be analyzed. Different operations of processing and post-processing magnesium workpieces enable the adjustment of distinct surface and subsurface properties. These properties are then utilized to adjust the corrosion resistance and therefore the degradation kinetics of the implant in the organism. Results of in-vitro an in-vivo experiments validate the strong relation between workpiece properties and corrosion behavior respectively degradation kinetics.
\n\t\t\tThe influence of different processes for the mechanical processing as well as the process input values and process parameters or tool geometries on the workpiece properties and the resulting degradation behavior are investigated on newly developed biocompatible magnesium alloys. Biomechanical characteristics of the samples produced are then analyzed and the influence of the corrosion attack on the biomechanical characteristics of the components is determined in different states of corrosion. In clinical in-vivo trials the degradation kinetics, the profile of biomechanical functions and the osseointegration of various implant demonstrators are investigated. The combination of the results of the in-vivo and in-vitro studies serves as a basis for the derivation of biomechanically relevant parameters and therefore for a definition of the medical requirements specifically for resorbable osteosynthesis implants. In the future, this profile of requirements will determine the implant design, the machining processes and the corresponding process parameters and therefore enables a conception of implants adapted to various indications.
\n\t\tIn Orthopaedics, implants such as screws, plates, intramedullary nails etc. are utilized for fracture fixation (osteosynthesis). Theses implants, which currently are mainly produced out of steel and titanium materials, are used for the support or fixation of traumatized bones and therefore, in most cases, only have a temporary function until the healing of the bone is completed. The formerly necessary revision surgery, which implies a certain risk for the patient as well as additional costs, can be avoided by utilizing degradable implants. In Orthopaedics and fracture fixation temporary bone implants therefore shall replace more and more permanent osteosynthetic materials, especially in the field of small volume implants (Weiler et al., 2000). These implants temporarily take over the function of the bone for a mechanical stabilization until after gradual degradation they are being replaced by newly built up bone tissue. The temporary implant materials utilized should guarantee a suitable mechanical stability and at the same time be completely degradable and should correspond to the supporting bone (cortical bone) regarding mechanical characteristics to avoid stress shielding (Daniels et al., 1990; Weiler et al., 1998, 2000). Until now, temporary implants are mainly produced out of PLA (polylactic acid, D and L isomers), PGA (polyglycolic acid), TMC (trimethylene carbonate), copolymers with varying substantial ratios, PDS (polydiaxonone) as well as composite materials (calcium phosphate in combination with polymers) (Anker et al., 2005; Ignatius et al., 2001a, 2001b; Sakar et al., 1999; Taylor et al., 1994). The field of application of these materials is however limited due to their relatively low mechanical strength. Therefore they can only be utilized in areas with low tensile, shear and compression forces (Wittenberg et al., 1991). Magnesium-based alloys specifically developed for medical applications offer significantly higher ultimate strengths, a higher Young’s modulus and a proven biocompatibility (Niemeyer et al., 2001; Wintermantel & Ha, 1996).
\n\t\t\tChip removing machining processes are generally used for shaping of medical implants because they guarantee a defined influence of the surface and subsurface, in contrast to other techniques such as forming. The flexibility of the design of the sample implants is an additional advantage of cutting machining processes. Regarding the resulting subsurface properties due to the different chip removing machining techniques there are still numerous questions to be answered. Due to the degradation of metallic implants mainly resulting from friction and corrosion, achieving defined subsurface properties in the production of function adapted medical implants is decisive. In the past few years, research on the influence of different surface machining techniques for implants on reactions of the organism has mainly been carried out in the field of dentofacial surgery. Research was mainly done with non-resorbable materials, especially titanium and titanium alloys. The surface topography was the center of attention (Gotz et al., 2004; Nasatzky et al., 2003; Schneider et al., 2003; Shalabi et al., 2006). Further studies showed that of the otherwise identical implants the ones with a thicker oxide layer created by heat treatment of the material lead to an earlier strong implant-bone compound (four weeks after implantation) but also revealed that this difference is being neutralized after a certain time, here 12 weeks after the implantation (Kim et al., 2003). Research on the influence of different shot peening methods during the production of roughed surface implants showed, that shot peening of titanium implants with bioceramics in compared to Al2O3 led to increased bone formation at the implant (Mueller et al., 2003). Though, these studies were carried out on permanent implant materials and therefore, the influence on surface, subsurface and implantation behavior illustrated is not transferrable to the resorbable implant material magnesium.
\n\t\t\tBesides the machining processes also mechanical surface treatment by means of hardening and softening or micro and macro residual stress can influence the subsurface conditions. Additionally, depending on the process and the parameters, changes of the surface topography can be achieved. These effects can increase the fatigue strength and therefore influence the behavior of the component (Broszeit & Adelmann, 1996; Scholtes & Vöhringer, 1996; Scholtes & Zinn, 1997). Residual compressive stress within the subsurface reduces the intensity of tension at the crack tips and reduces the crack formation and component distortion (Kloos et al., 1988; Nowag et al., 2007; Nüstedt et al., 1996; Brinksmeier et al., 2007). On rotationally symmetric components the supporting proportion could be increased by means of deep rolling. This led to improved operation characteristics as well as a significant improvement of fatigue strength and corrosion resistance. The corrosion speed and therefore the degradation behavior of magnesium-based alloys, besides its composition, especially depend on the surface and subsurface properties after machining. The properties can be adjusted by mechanical processing and it is known that these alterations have an influence on the component properties (Denkena et al., 2006a, 2008; Tomac & Tonnessen, 1991; Tönshoff et al., 2001; Winkler, 2000). First investigations with biocompatible magnesium alloys already show promising results regarding biomechanical properties and the potential to adjust the corrosion behavior (Denkena et al., 2006b, Denkena & Lucas, 2007). However, the fundamental relations between the mechanical processing and the resulting surface and subsurface properties of biocompatible magnesium alloys have not yet been investigated. Furthermore, the mechanisms of action of these properties regarding the corrosion behavior and therefore the kinetics of degradation of implants are still unknown. This knowledge is necessary to enable the function adjusted processing of small magnesium implants.
\n\t\t\tThe subsequent biomechanical investigation of resorbable screws, plates etc. regarding biomechanical characteristics for the application in orthopedic surgery, traumatology and maxillofacial surgery is oriented towards the testing of rigid materials. This currently implies the testing of compression forces, pull-out forces, shear strength and bending fatigue strength in corresponding test setups (Carano et al., 2005; DeCoster et al., 1990; Ignatius et al., 2005; Inceoglu et al. 2004; Seebeck et al., 2005; White et al., 2006). The application of synthetic bone out of polyurethane foams according to ASTM-standard F543 is usual (ASTM-Standard F543, 2002). The investigations are carried out on identical testing stands like e. g. the testing device “MTS 858 MiniBionix”.
\n\t\tFirstly, the relations between the particular process input values of the investigated mechanical processes for the production of implants such as cutting parameters, tool geometries or process control variables, regarding the resulting material removal processes and process forces as well as their influence on the surface topography and the subsurface are presented. Based on these findings, the influence of the modified surface and subsurface on the in vitro corrosion behavior is being determined in a time-resolved manner. Parallel the loss of function of implant demonstrators is being correlated to the corrosive weight loss in biomechanical investigations. The in-vivo trials on corrosion behavior and biomechanics allow the comparison of the time scales of in-vivo and in-vitro investigations. Considering the different time scales assumptions about the influence of mechanical processing on the degradation kinetics and the expected biomechanical loss of function can be made. The results of the different topic areas “Mechanical Processing”, “Clinical in vivo trials” and “Biomechanics” are outlined in the following.
\n\t\t\tThe focus of research in the field “Mechanical Processing” is placed on the clarification of the connections between mechanical processing and the in-vitro corrosion behavior. Therefore, the influence of machining processes with different chipping and non-chipping techniques and process kinematics on resulting surface and subsurface properties is analyzed and correlations with the in-vitro corrosion kinetics for different magnesium alloys are developed. All experiments described are carried out on alloys, which were developed for biomedical applications and provided as extruded profiles by the Institute of Material Science (IW) of the Leibniz Universität Hannover (Seitz et al., 2010). Subsequent in-vitro investigations of specifically modified workpieces provide information on the influence of different subsurface conditions on the degradation behavior. In these experiments the corrosion behavior is analyzed quantifiable and time-resolved.
\n\t\t\t\tAs a result, the parameters, which generate high passive forces (rolling pressure, cutting edge rounding), prove to be most significant. This passive force acts normally to the workpiece surface and is therefore significantly involved in the work hardening of the subsurface. The modification bandwidth of the corrosion behavior is significantly influenced by the surface properties (micro topography of the workpiece surface) and the residual compressive stress profile in the subsurface. The possibility for the modification of the corrosion kinetics by means of the subsurface condition also strongly depends on the alloy utilized. With the described machining processes and procedures also implant demonstrators were produced for biomechanical testing and clinical in vivo trials.
\n\t\t\t\tThe comprehensive characterization of the workpiece subsurface after machining provides information on the influence of cutting conditions and process parameters on the machining result. The interactions between different machining techniques, cutting materials, tool geometries and process parameters are investigated regarding plastic deformation of the surface, burr formation, surface quality and modification of the subsurface. Therefore the surface topography is analyzed by tactile and optical methods. Furthermore, a specially equipped SEM is used, which also serves for the EDX analysis of material components and corrosion products. In cooperation with the IW micro computer tomographic (µ-CT) analysis of corroded workpieces are carried out. In the characterization of the machined samples the depth-influence of the machining processes were especially focused on. Therefore, the subsurface is characterized by means of depth resolved micro hardness profiles, structural analysis and residual stress depth profiles. To be able to detect the residual stress condition, residual stress depth profiles for each of the differently machined samples are generated with an X-ray diffractometer using the sin²-ψ-method.
\n\t\t\t\tOn rotationally symmetric workpieces machining processes with rotational kinematics are applied. Deep rolling is used for the post processing of previously turned samples. Experiments to compare the capability of influencing properties of different materials were carried out on the alloys MgCa0.8 and MgCa3.0. Therefore, samples of both materials are machined by means of turning and deep rolling at identical process parameters. Rolling forces of 50 N and 200 N are adjusted via the hydraulic pressure of the hydrostatic deep rolling tool Ecoroll HG6, in which a hard material ball rolls over the workpiece surface.
\n\t\t\t\t\tInfluence on surface and subsurface after turning and deep rolling
Some of the surface and subsurface properties resulting from processing are shown in Figure 2 and Figure 3 show. The surface quality is significantly improved by the deep rolling process whereas no differences concerning the alloy can be detected. In addition to this, an increase in hardness of the subsurface is achieved by increasing the rolling pressure. This becomes more obvious in the MgCa0.8 alloy, which is of lower basic hardness. Deep rolling as a post processing method provides the possibility to induce residual compressive stress in the subsurface.
\n\t\t\t\t\t\n\t\t\t\t\t\tFigure 3 shows the induced residual stress for MgCa0.8 and MgCa3.0. After turning, only a minor influence on the residual stress very closely under the surface can be detected in both alloys. After deep rolling, though, a strong shift of the residual stress profile in the compressive direction can be detected. By means of a rolling force of 50 N a higher residual stress maximum of approx. 150 MPa at a low depth is achieved whereas it is only 120 MPa for a rolling force of 200 N. A rolling force of 200 N, though, achieves an influenced depth of approx. 800 µm.
\n\t\t\t\t\tThe results for different rolling forces correspond with the fundamental physical correlations of the Hertzian contact stress. Both alloys show similar subsurface properties and therefore similar possibilities of modification from the mechanical machining processes applied. The resulting corrosion characteristics will be described in a chapter below.
\n\t\t\t\t\tManipulation of subsurface after turning and deep rolling
To be able to analyze in the influence of milling processes on surface and subsurface properties, magnesium cylinders of the alloy MgCa0.8 are face-milled. Therefore, process parameters are systematically varied and different tools are used. Following, the results from the investigations with milling tools, that were utilized with sharp edged (rβ< 10 µm) and modified cutting edges are shown. To modify the tools, the edges were prepared with cutting edge radii of rβ = 100 µm and rβ = 200 µm by means of brushing. Figure 4 shows the SEM-pictures of the tool variants, an icon of the face-milling process and the resulting surface qualities after milling.
\n\t\t\t\t\tAt low cutting speeds, the surfaces created by honed tools are significantly rougher than on the samples machined with sharp cutting edges. The rounding leads to an undefined cutting process and therefore to increased formation of scratches and flakes. This effect disappears at higher cutting speeds and therefore increased thermal energy in the deformation zone in front of the cutting edge. Rising temperatures and increasing ductility of the material obviously lead to a smearing of the scratches and flakes and therefore a smoothing of the surface when using honed tools. The surface qualities resulting are similar to those of sharp tools.
\n\t\t\t\t\tBy using honed cutting edges in face milling also a significant influence on the subsurface is achieved. Figure 5 shows that subsurface properties regarding the residual stress profile are generated, that are similar to those after deep rolling. While sharp tools hardly cause changes in the subsurface, honed cutting edges induce residual compressive stresses up to approx. 400 µm of depth. The penetration depth can be increased by advanced rounding. A residual stress maximum of up to – 120 MPa can be achieved for both roundings. The maximum for the rounding of rβ = 200 µm can be located at a depth of approx. 100 µm and therefore a little deeper than for the rounding of rβ = 100 µm for which is located at a depth of approx. 70 µm. The penetration depth of influence can be increased from approx. 200 µm to approx. 400 µm be means of increased cutting edge rounding.
\n\t\t\t\t\tModified tools and surface qualities after milling
Influenced subsurface after milling with modified tools
To correlate the results of the studies on turning and milling, test series are carried out, in which similar process parameters are adjusted. Therefore similar chip thicknesses result for both machining methods. That is especially, because the residual stress is measured in the center of the milling path, where the chip thickness equals the feed per tooth. In both processes extruded materials (Ø = 20 mm) are used, which are turned to a diameter of Ø = 18 mm respectively milled into a half cylinder. Furthermore, turning and milling tools are prepared with similar cutting edge roundings (sharp rβ< 10 µm, rβ = 100 µm, rβ = 200 µm). Therefore, analogical relations exist between chip thickness and cutting edge radii. The results of the residual stress measurements illustrated in Figure 6 show similar tendencies in the depth profiles of the workpieces after turning and milling. There is only a minor modification of the subsurface for sharp tools. With increased rounding of the cutting edge squeezing effects and therefore plastic deformation of the material close to the surface increases, which induces residual compressive stress into the subsurface. This effect becomes even more significant in milling at increased cutting edge radii.
\n\t\t\t\t\tComparing the depth of impact of both processes, significant differences are detectable. In turning a depth influence of approx. 100 µm can be achieved, which cannot be increased by doubling the radius of the cutting edge. In milling with modified tools of rβ = 100 µm a depth of influence of up to approx. 200 µm can be achieved and for rβ = 200 µm a depth of up to approx. 400 µm.
\n\t\t\t\t\tComparison of the subsurface modification after turning and milling
The forces in passive direction can be considered as the main cause of this effect. These forces (Fp) directed normally toward the surface of the workpiece are on a higher level for milling than for turning. The continuous chip generation in turning with rounded tools obviously leads to a jam of material in front of the cutting edge. The jammed material does not flow neither over the cutting edge, nor below and therefore acts like a built-up edge. The negative effective rake angle resulting form the rounding of the cutting edge therefore does not come into effect and only a minor increase of the passive force is detected. The milling process shows that at the applied low cutting speed no ordinary built-up edge is generated. In discontinuous cutting the edge cannot form from jammed material because the height of the point of stagnation varies with the varying undeformed chip thickness and, in addition to this, the tool periodically gets out of contact with the work material.
\n\t\t\t\t\tThe discontinuous milling process also lies on a lower temperature level due to the cutting edge cooling in the interruption of cut. Furthermore, the machined surface and therefore the volume for a similar feed distance is larger in the turning process (proportional to the circumference U = 56.5 mm at Ø = 18 mm) than in the milling process (width of milling path b = 20 mm). The thermal influences inducing tensile residual stress are therefore lower in the milling process and the mechanical influences inducing compressive residual stress dominate. This is also confirmed by the residual stress of the surface, which hardly exceed -40 MPa in turning while in milling up to -80 MPa are achieved.
\n\t\t\t\tAfter analyzing the surface modifications and the depth effects of the subsurface modifications caused by machining processes, in vitro corrosion studies are performed, to examine the relation between these modifications and the impact on the corrosion behavior, especially on the corrosion profile over the time. It was observed how the corrosion characteristics of implants with modified subsurfaces change over time with regard to environmental influences. This provides information on the period of time in which the modified subsurface has an influence on the corrosion and degradation behavior of the implant (tlim in Figure 2). To be able to determine the influence of the modification of the surface and subsurface on the corrosion behavior, the corrosion progress of different subsurface modifications is monitored time-resolved and analyzed in the corrosion experiments.
\n\t\t\t\t\tDifferent surface and subsurface properties are adjusted on similar sample geometries in order to analyze the time behavior of the degradation induced by the machining. In the in vitro corrosion studies in physiological NaCl solution (0.9 wt% NaCl in deionized water) carried out. The mass of the corroding magnesium can be determined via continuously monitoring volume of the generated hydrogen released during the oxidation of magnesium. The samples are produced by means of the chip removing and non-chip removing processes described earlier.
\n\t\t\t\t\tThe studies on the machining influence on different magnesium materials revealed a major difference in the ability to influence different alloys, considering the corrosion. While the surface and subsurface properties resulting from machining are similar for both materials MgCa0.8 and MgCa3.0 (see above) the corrosion behavior of the two differs significantly. Only a minor influence of the mechanical processing on the resulting corrosion kinetics was revealed for MgCa0.8. Figure 7 and Figure 8 show that a very similar corrosion progress was revealed for turning and deep rolling of MgCa0.8 despite very different surface and subsurface properties. The µ-CT analyzes are performed in cooperation with the IW.
\n\t\t\t\t\tCorrosion kinetics of turned and deep rolled samples of different material
Corrosion morphology of turned and deep rolled samples of different material
The records of the release of hydrogen during the corrosion (Figure 7) as well as the evaluation in the µ-CT of the samples that were analyzed after a certain time (Figure 8, top) show that no significant differences concerning the corrosion behavior of MgCa0.8 are detectable for the machining methods and process parameters applied. The corrosion rates are at a similar level. The alloy MgCa3.0, though, showed a significantly different corrosion behavior. This alloy shows a strong sensitivity of the corrosion behavior towards the modification of the subsurface. The corrosion progresses monitored by means of the hydrogen generation over time (Figure 7) as well as the samples studied after certain corrosion times in the µ-CT (Figure 8 bottom) show a strong influence of the mechanical processing. A significant reduction of the corrosion rate can be achieved by means of deep rolling. A difference in the corrosion rates of MgCa3.0 in turned and deep rolled samples by a factor of up to 100 is proved by the corrosion studies. The turned MgCa3.0 samples are attacked very strongly and their surface is undermined and then even bursting by the corrosion attack. The corrosion in deep rolled samples progresses delayed and very homogenously. In contrast to the homogenous structure of MgCa0.8 in which the calcium is dissolved interstitially, in MgCa0.3 the phase of the less noble Mg2Ca is attacked stronger. The deep rolling process obviously has an effect of closing superficial mirco-pores and additionally the residual compressive stresses induced avoid a superficial formation and propagation of cracks. This prevents the corrosion front from progression toward the center of the workpiece and the subversion of the surface. This in turn results in an overall homogenous corrosion attack. Thus, besides the basic corrosion rate of an applied alloy not only the surface and subsurface properties are decisive for influencing the corrosion rate. But also the characteristics of the alloy regarding its micro structural composition and crystallization are of great importance in the achievable modification bandwidth. Therefore it can be distinguished between materials with a corrosion behavior sensitive to machining and those that can be modified only very limitedly.
\n\t\t\t\tThe connection between the surface and subsurface properties and the in vivo degradation behavior as well as the resulting biomechanical loss of function of implant demonstrators is investigated in the field “Clinical in vivo trials”. Therefore, the degradation kinetics of magnesium implants of different surfaces, subsurfaces and geometries were studied in experiments on rabbits.
\n\t\t\t\tTo study the influence of the mechanical processing on the surface and subsurface of cylindrical implant demonstrators and their corresponding corrosion behavior, a magnesium calcium alloy with a calcium content of 0.8 % is chosen. This shows good results in both, in vitro and in vivo pilot studies. Smooth and sandblasted implants as well as threaded cylinders out of MgCa0.8 are studied. Besides the testing of the in vivo corrosion characteristics also the biocompatibility in the implant-bone bonding and the osseointegration are tested. The cylinders are implanted into the cortico-spongy transition area of the medial condyle of femur and remained for evaluation periods of 3 and 6 months. Besides clinical and radiological monitoring µ-CT scans are made to evaluate the existence of bone formation, gas accumulations and the state of degradation of the implants at the end of the trial period and after explantation of the distale fermur. Then, the non-decalcified bone-implant-compound is embedded in artificial resin and analyzed histological, after the preperation of microtome sections. Further, the histological cross sections of the cylinders are studied by means of an SEM, including EDX.
\n\t\t\t\t\tThe investigations verify results from pilot studies: the sandblasted cylinders show the highest level of degradation and a n early loss of shape, the smooth cylinders degrade very slowly and homogeneously and the threaded cylinders show local corrosion attacks in the crest areas of the thread (Figure 9).
\n\t\t\t\t\tµ-CT scans of a smooth cylinder (a), sandblasted cylinder (b) and threaded cylinder (c) in the condyle of femur six months after implantation in the rabbit
The generation of gas as well as the biocompatibility correlates with the state of degradation. The faster degrading sandblasted cylinders show the strongest generation of gas with clearly visible bubbles under the skin in close vicinity to the implant in 50 % of the cases. Lymphocytes, plasma cells and foreign body cells, as signs of the immune response of the organism, appear most frequently in the tissue around the sandblasted implants. Smooth cylinders do not show any gas accumulations and the cellular reactions are minimal. The gas accumulation on the threaded cylinders is moderate. It was mostly only diffuse and small accumulations that appeared in the tissue. All of the implants led to the formation of small patches of cartilaginous tissue around the implants, which can be seen as an early stage of the remodeling of the bone. The further development of these patches has to be analyzed in studies over longer implantation periods. A slower and more consistent degradation as seen with the smooth implants is more favorable because the reaction of the surrounding tissue is the lowest.
\n\t\t\t\tThe osseointegration of screw geometries after different implantation periods (2, 4, 6 and 8 weeks) is tested. Due to the screw dimensions, the cortico-spongy transition area of the distal femur proved to be inappropriate in pre-tests. Therefore the screws are implanted in the lateral tibia of the rabbit at the level of the insertion site of the fibula. Screws out of the magnesium alloy MgCa0.8 and surgical steel 316L are utilized. The production of the screw occurs following the in vitro tests (comparable thread pitch and flank width) to be able to compare in vitro and in vivo results. During the testing period, clinical, radiological and in vivo µ-CT examinations are carried out, especially to evaluate the degree of bony and emphysematous formations. Even during the trials, an evaluation on the degradation of the Mg screws could be carried out via of the µ-CT data.
\n\t\t\t\t\tTensile forces of resorbable MgCa0.8 and permanent 316L steel screws after different implementation periods
At the end of the evaluation period the strength of the implant-bone compound is tested by biomechanical examinations: to evaluate the degree of osseointegration and biodegradation pull-out tests are carried out (Figure 10). A special test set-up was established that allows to pull out the screw demonstrators with geometries from the in vivo studies as well as from the in vitro studies for comparison. The pull-out tests show no significant difference between the maximum pull-out forces of MgCa0.8 and surgical steel after an implantation period of two weeks. The maximum pull-out force of MgCa0.8 hardly decreased within the first four weeks after the implantation. Only in the long term, a continuous decreasing of the pull-out forces is detected. In contrast to that, the pull-out force of surgical steel continuously increases during the period of implantation. Therefore, significantly higher pull-out forces are measured for the surgical steel after four, six and eight weeks. Eventually, the screws were analyzed in toto and, after embedding in artificial resin, in thick-sections by means of SEM and EDX.
\n\t\t\t\t\tThe muscles situated above the screw head (M. tibialis cranialis) are examined histological to evaluate the biocompatibility of the screws. The prepared paraffin sections were stained with H&E staining and analyzed (Figure 11). The histological analysis of the peri-implant tissue shows similar results for both implant materials, which proves the formation of a fibrotic layer between the screw head and the covering muscles. Macrophages, foreign body cells and heterophile granulocytes as well as small patches of necrotic tissue are identified. The analysis focuses on the evaluation of the degree of fibrosis (thickness of fibrotic layer), necrosis and the cellular infiltration (amount of macrophages, foreign body cells, heterophile granulocytes) and is carried out by means of semi-quantitative scoring (non-existent, insignificant, low-grade, medium-grade, high-grade, very high-grade). In the group of steel implants the thickness of the connective tissue, the degree of cellular infiltration and the necrosis decreases continuously. A decrease of the parameters analyzes also appears in the MgCa0.8 group, however only the first four to six weeks after surgery. At the end of the implantation period the parameters analyzed increase.
\n\t\t\t\t\tImmunhistochemical staining is applied to show CD3 and B-CD79α, by which small amounts of T- and B-lymphocytes are detectable in both groups (MgCa0.8 and steel 316L). In comparison to steel, fewer T-lymphocytes and more B-lymphocytes are traced in the MgCa0.8 group.
\n\t\t\t\t\tHistological scans of a muscle section after the implantation of an MgCa0.8 screw
In the field of “Biomechanics”, the influence of modified surface and subsurface conditions on the in vitro corrosion behavior under different loads is analyzed and the biomechanical loss of function due to degradation of the material is modeled. The performance of the implant demonstrators are tested in vitro under dynamic stresses. Different stresses of the samples are reproduced in biomechanical test setups. The analysis of components in graded states of corrosion provides information on the loss of function as a result of geometry changes and mass loss due to corrosion.
\n\t\t\t\tA newly developed and established corrosion test stand outlines the loss of function depending on the corrosion progress. The corrosion stand can be divided into three sub-units. The flow velocity is adjustable by a peristaltic pump, the first unit. The thermostat as a further unit indirectly warms up the corrosion solution, which is led through a heat bath. The temperature of the solution is checked by means of a thermometer before it flows into the corrosion chamber. The corrosion chamber is the third unit, which is adjustable for each demonstrator-geometry. The chamber design ensures a laminar flow within the corrosion chamber. The significant factors of corrosion such as flow velocity, temperature of the solution and its composition are adjustable in the corrosion stand. Hence, the influences of the modified surface and subsurface conditions on the in vitro corrosion behavior under static and dynamic stresses and the biomechanical loss of function due to degradation of the material can be determined.
\n\t\t\t\tThe aim of the investigation is to determine the maximum pull-out force without influence of the corrosive medium. MgCa0.8 screws with an outer diameter of 4 mm, a core diameter of 3 mm and a thread pitch of 1 mm are applied in this test. They are inserted into artificial bone out of polyurethane (SYNBONE AG, Neugutstrasse 4, CH- 7208 Malans). Density of cortical plate: 0.72 g/cm³ +/ 5%; Density of cancellous bone: 37 kg/m³ (DIN EN ISO 845). By means of a biomechanical test device (Bionix-MTS 14000, Technology Drive Eden Prairie, MN USA) the screws are exposed to an axial pull-out force that was linearly increased until the compound between screw and artificial bone failed.
\n\t\t\t\t\tPull out forces of screw demonstrators (left) and mean value of the force at failure after 24h, 48h, 72h, 96h of corrosion for groups of 8 screws (right)
In each test series eight screws are used. The results for the demonstrators without corrosion show a reproducible bone-screw fixation at a low standard deviation. This data serves as a reference value for the determination of the failure load of the bone-screw compound at different states of corrosion. The left diagram in Figure 12 shows an average pull-out force of 201.5 N at a standard deviation of 9.3 N that appeared in the pull-out tests.
\n\t\t\t\t\tTo detect the remaining maximum pull-out force after corrosion (24 h, 48 h, 72 h and 96 h) MgCa0.8 screws of an outer diameter of 4 mm, a core diameter of 3 mm and a thread pitch of 1 mm are applied. In the test stand they are inserted into the artificial bone out of polyurethane. The flow rate of the used HANK’s solution is set to 2 ml/h at an adjusted temperature of 37° C. After fixed intervals, the screws were stressed until failure by means of the MTS test device. For each corrosion period eight screws were tested: 8/24 h; 8/28 h; 8/72 h; 8/96 h. The maximum tensile force decreases under the influence of corrosion over time (see Figure 12, right) and the preliminary assumptions were therefore verified.
\n\t\t\t\tFor the design of implants and the prediction of the implant behavior in vitro results have to be correlated with those from the clinical in vivo experiments. Figure 13 shows similar tendencies in the development of biomechanical characteristics over time in both environments. A continuous function loss of the screw demonstrators is proved after corrosion in vitro and degradation in vivo, respectively. Furthermore, a strong scaling of the behavior over time becomes obvious. While the decrease of the tensile force of approx. 30 % occurs within 100 h in vitro, a similar function loss in vivo only occurs after about 1000 h. The time profiles of the investigated biomechanical characteristics therefore are accelerated ten times approximately under in vitro conditions.
\n\t\t\t\tComparison of the biomechanical loss of function in vivo and in vitro
Revision surgeries on implants are a significant cost driver in public health care. Avoiding the material removal surgeries, resorbable implants out of magnesium therefore offer a great potential for cost reduction. Additionally, the patient is not unnecessarily put to risk.
\n\t\t\tThe works presented focus on the idea of “intelligent osteosynthesis” in which implants with a specific degradation profile are subjected to a stability loss, which is adjusted to the increasing stability of the healing bone. The presented results show that specific surface and subsurface modifications can be achieved by means of adapted machining processes and for suitable alloys the resulting corrosion behavior can be adjusted in vitro and the degradation profile in vivo, respectively. Biomechanical tests prove a continuous stability loss due to degradation in vitro and in vivo.
\n\t\t\tIn the future, the application of resorbable implants enables new areas of indication by the development of implant designs adapted to the material and the expected degradation as well as by new methods for the production including an adapted mechanical processing of these magnesium implants. Producing these implants in industrial production processes that guarantee specific implant properties without exceeding the production costs of currently used implants will be challenging. To enable the clinical application and achieve the marketability for load bearing resorbable magnesium implants, future tasks will focus the development and adaptation of the production technology and the adjustment of specific implant properties corresponding with the geometrical implant design. At sufficient stability, fatigue strength, resulting in a stable osteosynthesis until completion of the bone healing, the field of application of load bearing resorbable implants can be made accessible.
\n\t\tThe investigations described in this paper were funded by the German Research Foundation (DFG) within the subproject R4 of the collaborative research center SFB 599 “Sustainable Bioresorbable and Permanent Implants of Metallic and Ceramic Materials“.
\n\t\tThis is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
",metaTitle:"Publishing Process Steps and Descriptions",metaDescription:"This is a brief overview of the main steps involved in publishing with InTechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Publishing Process Manager who will be your single point of contact and lead you through all the described steps below.",metaKeywords:null,canonicalURL:"page/publishing-process-steps",contentRaw:'[{"type":"htmlEditorComponent","content":"1. SEND YOUR PROPOSAL
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\n\nPlease complete the publishing proposal form. The completed form should serve as an overview of your future Compacts, Monograph or Edited Book. Once submitted, your publishing proposal will be sent for evaluation, and a notice of acceptance or rejection will be sent within 10 to 30 working days from the date of submission.
\n\n2. SUBMIT YOUR MANUSCRIPT
\n\nAfter approval, you will proceed in submitting your full-length manuscript. 50-130 pages for compacts, 130-500 for Monographs & Edited Books.Your full-length manuscript must follow IntechOpen's Author Guidelines and comply with our publishing rules. Once the manuscript is submitted, but before it is forwarded for peer review, it will be screened for plagiarism.
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This technique is called power over fiber (PoF). Besides the advantages of optical fiber (immunity to electromagnetic interferences and electrical insulation), the employment of a PoF scheme can eliminate the energy supplied by metallic cable and batteries located at remote sites, improving the reliability and the security of the system. Smart grid is a green field where PoF can be applied. Experts see smart grid as the output to a new technological level seeks to incorporate extensively technologies for sensing, monitoring, information technology, and telecommunications for the best performance electrical network. On the other hand, in telecommunications, PoF can be used in applications, such as remote antennas and extenders for passive optical networks (PONs). PoF can make them virtually passives. 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