Myths related to cooking with EVOO.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5248",leadTitle:null,fullTitle:"Structural Bridge Engineering",title:"Structural Bridge Engineering",subtitle:null,reviewType:"peer-reviewed",abstract:"There are many books on preliminary studies and research in bridge design as well as basic knowledge on bridge engineering, but most books supply the needs of practicing engineers who may have problems in estimating, designing or constructing suspension bridges. Therefore, this book is intended to serve as a source of information for problems related to bridge engineering including sustainable bridge development, traditional approaches and recent advances in highway bridge traffic loading, aesthetic analysis issues in designing a new bridge, applications of various methods for the dissipation of seismic energy for bridges, new technologies of bridge design as well as structural identification of bridges using non-destructive experimental measurement tests.",isbn:"978-953-51-2689-8",printIsbn:"978-953-51-2688-1",pdfIsbn:"978-953-51-6684-9",doi:"10.5772/61683",price:119,priceEur:129,priceUsd:155,slug:"structural-bridge-engineering",numberOfPages:198,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"8a6b781d7ca98b6008887c99915a62ec",bookSignature:"Shahiron Shahidan, Shahrul Niza Mokhatar, Mohd Haziman Wan Ibrahim, Norwati Jamaluddin, Zainorizuan Mohd Jaini and Noorwirdawati Ali",publishedDate:"October 12th 2016",coverURL:"https://cdn.intechopen.com/books/images_new/5248.jpg",numberOfDownloads:14900,numberOfWosCitations:3,numberOfCrossrefCitations:8,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:9,numberOfDimensionsCitationsByBook:2,hasAltmetrics:0,numberOfTotalCitations:20,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 3rd 2015",dateEndSecondStepPublish:"November 24th 2015",dateEndThirdStepPublish:"February 20th 2016",dateEndFourthStepPublish:"March 21st 2016",dateEndFifthStepPublish:"June 27th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"145588",title:"Dr.",name:"Shahiron",middleName:null,surname:"Shahidan",slug:"shahiron-shahidan",fullName:"Shahiron Shahidan",profilePictureURL:"https://mts.intechopen.com/storage/users/145588/images/system/145588.jpg",biography:"Ts. Dr. Shahiron Shahidan CEng MIET, was born in Perlis, Malaysia, in 1983. He received his early education at Sekolah Kebangsaan Kampong Salang, Perlis. He continued his secondary education at Al Madrasah Al Alawiyah Ad Diniah, Arau Perlis, and Sekolah Menengah Teknik Butterworth, Penang. He furthered his studies and graduated in 2007 with a B. Eng. (Civil) (Hons) from the University Industry Selangor. After graduation, Dr. Shahidan was employed as a Bridge Engineer at a consulting engineering firm (HSS Integrated, Bandar Sri Permaisuri, Kuala Lumpur) for almost a year before making an academic career switch at Universiti Tun Hussein Onn Malaysia (UTHM). In 2008, Dr. Shahidan furthered his studies at a master’s degree level and graduated with a Master in Structural Engineering from Universiti Putra Malaysia (UPM). In 2014 he completed his PhD. in Structural Engineering at the University of Science, Malaysia (USM). Currently, he is a Senior Lecturer in the Department of Structural and Material Engineering at the Faculty of Civil and Environmental Engineering, Universiti Tun Hussein Onn Malaysia (UTHM), Malaysia. Dr. Shahidan has experience teaching undergraduate and graduate courses such as Bridge Design, Railway Engineering, Prestressed Concrete Design, Reinforced Concrete Design and Structural Analysis. Throughout his studies and career, he was involved in a number of professional international and national societies . He is a Chartered Engineer (CEng) from Engineering UK, Member of The Institution Engineering Technology (MIET), Profesional Tecnologist (P.Tech),Member of the Board of Engineers Malaysia (BEM); Member of the American Concrete Institute (ACI), Kuala Lumpur, Malaysia; Member of the Concrete Society of Malaysia (CSM); and Grad. Engr. of the Institution of Engineers Malaysia. Dr. Shahidan has also been actively publishing his work in high-impact journals, Thomson Reuters and Scopus indexed, he wrote several book chapters while also being active as a conference attender and oftenly a keynote speaker.",institutionString:"Tun Hussein Onn University of Malaysia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Tun Hussein Onn University of Malaysia",institutionURL:null,country:{name:"Malaysia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"202629",title:"Dr.",name:"Mohid Haziman",middleName:null,surname:"Wan Ibrahim",slug:"mohid-haziman-wan-ibrahim",fullName:"Mohid Haziman Wan Ibrahim",profilePictureURL:"https://mts.intechopen.com/storage/users/202629/images/system/202629.png",biography:"Dr. Mohd Haziman Wan Ibrahim is an Associate Professor at the Department of Structure and Material Engineering at the Universiti Tun Hussein Onn Malaysiat. He graduated in Civil Engineering from the Universiti Tun Hussein Onn Malaysia (UTHM), Malaysia, in 2004 and in 2011 he has been awarded Ph.D. in philosophy from the same university. \nHe is involved in different projects in the field of concrete technology and masonry engineering. He has authored more than 60 publications.",institutionString:"Tun Hussein Onn University of Malaysia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Tun Hussein Onn University of Malaysia",institutionURL:null,country:{name:"Malaysia"}}},coeditorTwo:{id:"202630",title:"Dr.",name:"Norwatie",middleName:null,surname:"Jamaluddin",slug:"norwatie-jamaluddin",fullName:"Norwatie Jamaluddin",profilePictureURL:"https://mts.intechopen.com/storage/users/202630/images/5021_n.jpg",biography:"Dr. Norwati Jamaluddin is lecturer at the Department of Structure and Material Engineering at the Universiti Tun Hussein Onn Malaysiat since 2003.\nShe graduated in Structural Engineering from the Universiti Teknologi Malaysia in 2003 and in 2011 she has been awarded Ph.D. in philosophy from the University of Leeds. \nHer major research interests are in steel structural, composite steel-concrete structural, finite element modeling. \nDr. Jamaluddin is a member of the International Association Protective Structures (IAPS)\n, of the Malaysian Steel Structural Association (MSSA)\n and she is a member of the Board of Engineers Malaysia (BEM). She has authored several articles in international journals and attended local and international conferences.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorThree:{id:"202631",title:"Dr.",name:"Noorwirdawati",middleName:null,surname:"Ali",slug:"noorwirdawati-ali",fullName:"Noorwirdawati Ali",profilePictureURL:"https://mts.intechopen.com/storage/users/202631/images/5020_n.png",biography:"Dr. Noorwirdawati Ali is Senior Lecturer at the Department of Structure and Material Engineering at the Universiti Tun Hussein Onn Malaysiat. She has been awarded Ph.D. in Civil Engineering from the Universiti Tun Hussein Onn Malaysia, Malaysia, in 2014. \nShe has authored several articles and attended local and international conferences. Dr. Ali is a member of the Board of Engineers Malaysia.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorFour:{id:"202632",title:"Dr.",name:"Sharulniza",middleName:null,surname:"Mokhatar",slug:"sharulniza-mokhatar",fullName:"Sharulniza Mokhatar",profilePictureURL:"https://mts.intechopen.com/storage/users/202632/images/5022_n.png",biography:"Dr. Shahrul Niza Bin Mokhatar is a senior lecturer at the Department of Structure and Material Engineering at the Universiti Tun Hussein Onn Malaysiat .\nHe has been awarded Ph.D. in Civil Engineering from Kyushu University in 2013. Dr. Mokhatar\\'s major research interests are structural engineering, computational modeling of reinforced concrete (nonlinear finite element analysis, smoothed particle hydrodynamics method) and impact engineering.\nHe is a member of the Board of Engineers Malaysia (BEM)\n, of The Institution of Engineers, Malaysia (IEM)\n, of the International Association of Protective Structures (IAPS)\n and a nembe of the Japan Concrete Institute (JCI).\nHe has authored more than ten articles in international journals and nine conference/proceeding publications.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorFive:{id:"202633",title:"Dr.",name:"Zainorizuan",middleName:null,surname:"Mohd Jaini",slug:"zainorizuan-mohd-jaini",fullName:"Zainorizuan Mohd Jaini",profilePictureURL:"https://mts.intechopen.com/storage/users/202633/images/5023_n.png",biography:"Dr. Zainorizuan Mohd Jaini is a senior lecturer and researcher at the Department of Structure and Material Engineering at the Universiti Tun Hussein Onn Malaysiat.\nHe has been awarded Ph.D. in Civil and Computational Engineering) from Swansea University, UK. \nDr. Mohd Jaini research interests are structural damage and dynamic responses under high loading rates, finite/discrete element method\n, computational multi-scale modeling, vibration and progressive collapse\n, innovative structures. \nHe is a member of the Institution of Structural Engineers (ISE), the Institution of Engineers Malaysia (IEM), Association for Computational Mechanics in Engineering (ACME), International Association of Protective Structures (IAPS), International Association for Computational Mechanics (IACM), European Association for Structural Dynamics (EASD), Concrete Society of Malaysia (CSM). \nHe has authored more than twenty publications between journal articles and conference proceedings.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},topics:[{id:"712",title:"Structural Engineering",slug:"engineering-civil-engineering-structural-engineering"}],chapters:[{id:"50780",title:"History of Sustainable Bridge Solutions",doi:"10.5772/63461",slug:"history-of-sustainable-bridge-solutions",totalDownloads:2305,totalCrossrefCites:3,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The chapter is a voice in the discussion concerning sustainable bridge development. Nowadays, the term has rather been abused, and therefore the presented approach refers to these elements of design, construction and maintenance of bridges—with regard to their role in transport and social life—which have been present in bridge construction for a long time and can be easily incorporated into the concept of sustainable bridge construction. Sustainable development, sustainable construction and so on are multidimensional. In the considered bridge construction area, looking at construction processes as interfering with the environment and which could and should be restricted is a new element. Nevertheless, other proven constructional solutions and technologies are characterised by their reliability. Assuming that the constructed bridges are to serve the next two or three generations of users, we can try to extrapolate current technical conditions on the next 30 or 60 years, i.e., up to three generations. We can do it if we know and are able to critically assess the history of bridge construction. Following this reasoning, the history in question is referred to in this paper, although rather subjectively and with the omission of numerous important personalities and technologies as well as instructive failures due to the publishing limitations.",signatures:"Slawomir Karas",downloadPdfUrl:"/chapter/pdf-download/50780",previewPdfUrl:"/chapter/pdf-preview/50780",authors:[{id:"182839",title:"Dr.",name:"Slawomir",surname:"Karas",slug:"slawomir-karas",fullName:"Slawomir Karas"}],corrections:null},{id:"51540",title:"Highway Bridge Traffic Loading",doi:"10.5772/63967",slug:"highway-bridge-traffic-loading",totalDownloads:2103,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In this chapter, traditional approaches and recent advances in highway bridge traffic loading are described, which are of great significance for structural safety assessment of bridges. Indeed, it is widely accepted that consideration of site-specific traffic features can enable significant savings in maintenance operations. While short spans are governed by free-flowing traffic plus an allowance for the dynamic effects, long spans are governed by congested conditions. For the former, a promising research trend is the investigation of the dynamic vehicle-bridge interaction, which is shown to lead to dynamic effects much lower than previously thought. For the latter, advances in traffic flow modelling enable the simulation of realistic congestion patterns based on widely available free-flowing traffic data, thus partially overcoming a long-standing shortage of congestion data. Here, emphasis is given to the promising application of traffic microsimulation to long-span bridge loading, combined with a probabilistic approach based on the extreme value theory, to compute site-specific characteristic loading values.",signatures:"Alessandro Lipari",downloadPdfUrl:"/chapter/pdf-download/51540",previewPdfUrl:"/chapter/pdf-preview/51540",authors:[{id:"183534",title:"Dr.",name:"Alessandro",surname:"Lipari",slug:"alessandro-lipari",fullName:"Alessandro Lipari"}],corrections:null},{id:"51848",title:"3D and 4D Models Used in Bridge Design and Education",doi:"10.5772/64675",slug:"3d-and-4d-models-used-in-bridge-design-and-education",totalDownloads:2109,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"A bridge is the type of structure whose appearance normally deserves more attention because it not only has an evident impact on the environment but also represents considerable investment, both of which justify careful evaluation. The aesthetic analysis is an important issue that must be considered when designing a new bridge, especially when it is to be built in an urban or road environment. In this context, the automatic generation of three‐dimensional (3D) geometric models of the bridge under analysis, and the walk around and aerial simulation allowed over it, which can be generated, helps bridge designers to evaluate its aesthetic concept and environmental impact. The bridge construction process can also be simulated, helping designers and builders to review the progress of the construction work in situ. For that, 4D (3D + time) models of the most frequent bridge construction methods were generated, using virtual reality (VR) technology. The simulation of the construction activity made possible by the developed interactive 4D model helps bridge designers to analyse the whole construction process. The present study aims to analyse the mechanisms of how to generate 3D models of a bridge automatically and how to simulate its construction using VR capacities.",signatures:"Alcínia Z. Sampaio",downloadPdfUrl:"/chapter/pdf-download/51848",previewPdfUrl:"/chapter/pdf-preview/51848",authors:[{id:"13640",title:"Prof.",name:"Alcínia Zita",surname:"Sampaio",slug:"alcinia-zita-sampaio",fullName:"Alcínia Zita Sampaio"}],corrections:null},{id:"52386",title:"The Structural Performance of Stone-Masonry Bridges",doi:"10.5772/64752",slug:"the-structural-performance-of-stone-masonry-bridges",totalDownloads:3501,totalCrossrefCites:5,totalDimensionsCites:7,hasAltmetrics:0,abstract:"The structural performance of old stone-masonry bridges is examined by studying such structures located at the North-West of Greece, declared cultural heritage structures. A discussion of their structural system is included, which is linked with specific construction details. The dynamic characteristics of four stone bridges, obtained by temporary in situ instrumentation, are presented together with the mechanical properties of their masonry constituents. The basic assumptions of relatively simple three-dimensional (3-D) numerical simulations of the dynamic response of such old stone bridges are discussed based on all selected information. The results of these numerical simulations are presented and compared with the measured response obtained from the in situ experimental campaigns. The seismic response of one such bridge is studied subsequently in some detail as predicted from the linear numerical simulations under combined dead load and seismic action. The performance of the same bridge is also examined applying 3-D non-linear numerical simulations with the results used to discuss the structural performance of stone-masonry bridges that either collapsed or may be vulnerable to future structural failure. Issues that influence the structural integrity of such bridges are discussed combined with the results of the numerical and in situ investigation. Finally, a brief discussion of maintenance issues is also presented.",signatures:"George C. Manos, Nick Simos and Evaggelos Kozikopoulos",downloadPdfUrl:"/chapter/pdf-download/52386",previewPdfUrl:"/chapter/pdf-preview/52386",authors:[{id:"43298",title:"Dr.",name:"Nikolaos",surname:"Simos",slug:"nikolaos-simos",fullName:"Nikolaos Simos"},{id:"152143",title:"Prof.",name:"George",surname:"Manos",slug:"george-manos",fullName:"George Manos"},{id:"185538",title:"M.Sc.",name:"Evangelos",surname:"Kozikopoulos",slug:"evangelos-kozikopoulos",fullName:"Evangelos Kozikopoulos"}],corrections:null},{id:"51368",title:"Different Solutions for Dissipation of Seismic Energy on Multi-Span Bridges",doi:"10.5772/63821",slug:"different-solutions-for-dissipation-of-seismic-energy-on-multi-span-bridges",totalDownloads:1582,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter deals with the application of various methods for the dissipation of seismic energy in order to adjust the response to seismic forces of an existing bridge with multiple spans.",signatures:"Alessandro Contin and Andrea Mardegan",downloadPdfUrl:"/chapter/pdf-download/51368",previewPdfUrl:"/chapter/pdf-preview/51368",authors:[{id:"182884",title:"Dr.",name:"Andrea",surname:"Mardegan",slug:"andrea-mardegan",fullName:"Andrea Mardegan"},{id:"182886",title:"Dr.",name:"Alessandro",surname:"Contin",slug:"alessandro-contin",fullName:"Alessandro Contin"}],corrections:null},{id:"50890",title:"Fluid Viscous Dampers and Shock Transmitters in Realization of Multi-Span Steel-Concrete Viaducts",doi:"10.5772/64038",slug:"fluid-viscous-dampers-and-shock-transmitters-in-realization-of-multi-span-steel-concrete-viaducts",totalDownloads:1651,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter discusses the methodology for the dissipation of seismic energy, designed for the construction of a steel-concrete viaduct in a variable-orography land. The viaduct has a total length of 1102 m and typical spans of 75 m, with piers, of a maximum height of 65 m, significantly varies from each other. The viaduct is subjected to a redesign step in order to adapt it to the requirements of Italian standard ‘D.M. 14/01/2008’. The new design has reformulated the sequence of spans and, consequently, redefined the structures constituting the foundations, piles, steel girders, inferior bracings and especially the typology of bearings and seismic devices.",signatures:"Alessandro Contin and Andrea Mardegan",downloadPdfUrl:"/chapter/pdf-download/50890",previewPdfUrl:"/chapter/pdf-preview/50890",authors:[{id:"182884",title:"Dr.",name:"Andrea",surname:"Mardegan",slug:"andrea-mardegan",fullName:"Andrea Mardegan"}],corrections:null},{id:"51519",title:"Nondestructive Testing Structural Bridge Identification",doi:"10.5772/64288",slug:"nondestructive-testing-structural-bridge-identification",totalDownloads:1649,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The bridges are one of the most important engineering structures. Determination of the bridge responses during their service life has gained great importance using nondestructive test methods with the changing of aims, usages, environmental conditions, material deteriorations by time, and damages during some dramatical events. This chapter presents the nondestructive experimental measurement test results of the bridges for structural identification. Ten different bridges, which have different type and carrier systems, such as historical masonry arch bridges, long span concrete highway bridges, base isolated bridges, footbridges, steel bridges, and old riveted bridges, are selected for numerical examples. The measurements are conducted under environmental excitations of pedestrian movement, traffic, wind-induced vibration, and the response signals are collected using uniaxial- and triaxial-sensitive seismic accelerometers. Operational modal analysis or ambient vibration tests are performed to extract the dynamic characteristics such as natural frequencies, mode shapes, and damping rations using enhanced frequency domain decomposition method in the frequency domain and stochastic subspace identification method in the time domain. It is demonstrated that the ambient vibration measurements are enough to identify the most significant modes of all bridge types.",signatures:"Ahmet Can Altunışık",downloadPdfUrl:"/chapter/pdf-download/51519",previewPdfUrl:"/chapter/pdf-preview/51519",authors:[{id:"181092",title:"Dr.",name:"Ahmet Can",surname:"Altunişik",slug:"ahmet-can-altunisik",fullName:"Ahmet Can Altunişik"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5503",title:"Wood in Civil Engineering",subtitle:null,isOpenForSubmission:!1,hash:"fb659c92f0d45acc8f960d9a656b54e2",slug:"wood-in-civil-engineering",bookSignature:"Giovanna Concu",coverURL:"https://cdn.intechopen.com/books/images_new/5503.jpg",editedByType:"Edited by",editors:[{id:"108709",title:"Dr.",name:"Giovanna",surname:"Concu",slug:"giovanna-concu",fullName:"Giovanna Concu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2193",title:"Advances on Analysis and Control of Vibrations",subtitle:"Theory and Applications",isOpenForSubmission:!1,hash:"926bac5ebecf5b70140e42105b5e2527",slug:"advances-on-analysis-and-control-of-vibrations-theory-and-applications",bookSignature:"Mauricio Zapateiro de la Hoz and Francesc Pozo",coverURL:"https://cdn.intechopen.com/books/images_new/2193.jpg",editedByType:"Edited by",editors:[{id:"148213",title:"Dr.",name:"Mauricio",surname:"Zapateiro",slug:"mauricio-zapateiro",fullName:"Mauricio Zapateiro"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8822",title:"Advances in Structural Health Monitoring",subtitle:null,isOpenForSubmission:!1,hash:"429d24d493e64821ae08df0a71d33e37",slug:"advances-in-structural-health-monitoring",bookSignature:"Maguid H.M. 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Diabetes mellitus is one of the most prevalent chronic diseases in children. Diabetes mellitus is classified into four major types. Type 1, type 2, gestational, and other specific types. Type 1 diabetes (T1D) is caused by autoimmune destruction of the insulin-producing beta cells of the pancreas. Type 2 diabetes (T2D) results from a combination of insulin resistance and beta cell insulin secretory defect. The rising prevalence of childhood obesity has made it more difficult to differentiate between these types of diabetes in children. There is a new expression of diabetes in children known as double diabetes, or hybrid diabetes. This is a clinical state where both T1D and T2D co-exist in the same individual as shown in Figure 1 below.
Childhood obesity is one of the most serious public health challenges of the 21st century [1]. According to the National Health and Nutrition Examination Survey data, about 16% of children and adolescents in the United States have a body mass index (BMI) (kg/m2) ≥95th percentile for age and gender [2]. Body mass index of >95th percentile is classified as overweight by the Center for Disease Control and Prevention [3,4], and as obesity by European criteria [5].
The prevalence of obesity has tripled in the past three decades [6] among male and female adolescents, and across different racial and ethnic groups [6-8]. There has also been a parallel increase in the prevalence of many obesity-related co-morbid conditions [9] such as T2D, dyslipidemia, hypertension, obstructive sleep apnea, poor quality of life and mortality in adulthood [10-13]. Although obesity is associated primarily with T2D due to insulin resistance, [14], it may also impact T1D morbidity.
T1D is caused by autoimmune destruction of the beta cells of the pancreas leading to insulinopenia. It is sub-classified into 2 main categories- type 1A and 1B [15]. In type 1A, individuals have one or more of the anti-islet cell (including glutamic acid decarboxylase, and insulinoma antigen-2) or anti-insulin antibodies. In type 1B these antibodies are absent, but the clinical and biochemical features are similar to 1A. T2D is characterized by insulin resistance and absence of diabetes-associated antibodies in serum.
A new subset of diabetes, called double diabetes is becoming increasingly prevalent as a result of the epidemic of childhood obesity [16-18]. In double diabetes, elements of both T1D and T2D co-exist. In this condition, individuals with T1D have insensitivity to insulin that is most often associated with obesity; and individuals with T2D have antibodies against the pancreatic beta cells [14] (Figure 1). Unlike T1D and T2D, there is no consensus on the therapeutic modalities for double diabetes.
The incidence of both T1D and T2D is rising in children and adolescents [14]. Data from the EURODIAB study indicate that the overall prevalence of T1D among young people under 15 years is increasing by greater than 3% each year, and by more than 6% a year in children aged up to four years [19].Analysis of the 2002 to 2003 data from SEARCH for Diabetes in Youth, a multicenter study funded by the Centers for Disease Control and Prevention and the National Institutes of Health to examine T1D and T2D among children and adolescents in the United States, showed that annually, about 15,000 youth in the United States are newly diagnosed with T1D, and about 3,700 youth with T2D. The reported rate of new cases among youth was 19 per 100,000 each year for T1D, and 5.3 per 100,000 for T2D [20].
The prevalence of double diabetes is unknown [16]. However, reports show that about 25% of children with T1D are either overweight or obese [21]. Other reports show that about 35% of children and adolescents with T2D have at least one diabetes-associated antibody [22]. Some authors estimate that about one in three children and adolescents with newly diagnosed diabetes has double diabetes. Pozzilli et al reported a prevalence of 4.96% in their unpublished Italian cohort [1]. The major difficulty with establishing a prevalence rate for double diabetes is that there are no precise definitions for the different types of diabetes presenting in youth [1]. This is because clinical phenotypes frequently overlap at onset of the disease [1]. For example, obesity and ketoacidosis can be found in both T1D and T2D [23], and the age of diagnosis is now a poorly differentiating factor [24]. In other cases, the clinical features of double diabetes are not apparent at diagnosis but evolve over time [18].
There are genetic, environmental and behavioral factors that affect the pathophysiological processes of T1D and T2D in such as way to result in double diabetes. Obesity is the central pathophysiological mechanism for double diabetes. Obesity may arise from genetic predisposition or from environmental factors such as the anabolic role of insulin injection in patients with T1D who fail to make the necessary healthy lifestyle changes that are recommended for maintenance of normal weight.
Unlike T1D where the
Apart from the principal genetic determinants of T1D and T2D, there are a number of genes that could potentially lead to an outcome of double diabetes by influencing the pathogenetic processes operating in both T1D and T2D [32]. One of such genes resulting from a genetic variance in insulin receptor substrate 1 (
The epidemic of childhood obesity has led to increased diagnosis of metabolic syndrome and T2D in all children including those with existing T1D [35]. Obese or overweight children have been reported to develop T1D at younger ages than children of normal weight [35]. The SEARCH for Diabetes in Youth Study [36] reported an obesity prevalence rate of 12.6% in US youth with T1D. The study also reported a higher prevalence of overweight status (BMI 85th – 95th percentile) among youth with T1D than in those without diabetes (22.1% vs. 16.1%) (P<0.05). Some children with T1D have either a first- or second-degree relative with T2D [1]. Furthermore, weight gain is prevalent in adolescents with T1D after attainment of adult height, which might further impair insulin sensitivity [37].
Therefore, several enviromental factors could lead to the development of double diabetes by their influence on the disease processes of T1D and T2D. Many of the major genetic factors involved in the etiopathogenesis of T2D appear to promote the development of the disease through their influence on obesity and feeding behavior [38]. There is evidence that rapid growth and obesity in early childhood might increase the risk of T1D [35,39]. The strong environmental basis for this obesity pandemic and influence on feeding behavior was recently outlined in a World Health Organization Technical Report [40] which states that ‘Changes in the world food economy have contributed to shifting dietary patterns, for example, increased consumption of energy-dense diets high in fat, particularly saturated fat, and low in unrefined carbohydrates. These patterns are combined with a decline in energy expenditure that is associated with sedentary lifestyle, motorized transport, labor-saving devices at home, the phasing out of physically-demanding manual tasks in the workplace, and leisure time that is preponderantly devoted to physically undemanding pastimes’. However, despite the established association between obesity and the increasing prevalence of T1D, it is unclear how these environmental processes lead to β cell destruction.
Several mechanistic models have been proposed to explain this phenomenon. Some reports have linked high titers of glutamic acid decarboxylase autoantibody to an increase in body mass index (BMI) [41] which suggests that increased BMI might favor the development of an autoimmune response towards β cells. This is in line with other reports indicating that a combination of obesity and insulin resistance speeds up the process of beta cell destruction [35,42]. Other proposed mechanisms for beta cell destruction include the the role of upregulation of autoimmune response by obesity-associated inflammatory cytokines, and hyperleptinemia-associated T-cell activation [43,44].
Other researchers have proposed the following mechanism for obesity-induced insulin resistance : (a) the liberation of large amounts of non-esterified fatty acids by visceral fat which stimulate neoglucogenesis in the liver and diminish glucose uptake in the muscles; (b) the association of obesity with increased activity of the sympathetic nervous system, which in combination with direct release of tumor necrosis factor, resistin and other adipocytokines contribute to insulin resistance; (c) the role of the accummulation of local intramyocellular triglycerides on muscle insulin senstivity [45].
In additon to the above mechanistic models, several hypotheses have been advanced to explain the association between obesity and rising prevlaence of T1D. The most prominent of these hypotheses is the accelerator hypothesis which states that T1D and T2D are the same disease state set in different genetic backgrounds [46]. It originally proposed three major factors as the basis for the development of diabetes: genetic predisposition, insulin resistance and intrinsic rate of beta cell loss. The accelerators have now been reduced to two without altering the premise of the hypothesis [46]. The first is insulin resistance which is believed to accelerate β-cell apoptosis while rendering them more immunogenic. It posits that insulin resistance is the primary driver for the development of diabetes in a susceptible individual and argues that insulin resistance increases through weight gain as does the rate of onset of diabetes [47]. The second accelerator is the hierachy of responsive genes whose reactivity modulates the gradient of β-cell declining function [46].
The central premise of the accelerator hypothesis is based on studies reporting rising incidence of obesity [6,48] and T1D in children [49,50]. These findings were strengthened by reports of an association between weight gain and an increased risk to develop diabetes mellitus [51-53], as well as several reports from Europe indicating that an increasing number of children are being diagnosed with T1D at an earlier age [54-58]. This hypothesis proposes a direct cause and effect relationship between obesity and the development of both T1D and T2D, and states that as the population becomes heavier (fatter), diabetes appears earlier, thus suggestive of a true acceleration rather than an incidental risk association [59].
The accelerator hypothesis is controversial because studies designed to prove its validity have reached various conclusions [35,60-65]. Reports from the United Kingdom indicated a relationship between younger age at diagnosis of T1D and higher body mass index (BMI) in Middlesbrough [35], and Plymouth [64],but not in Birmingham [61]. Other European studies of large cohorts of German and Austrian children with T1D supported the hypothesis [62,63], although studies from Spain and Australia [66,67] did not. Two studies have been conducted in the United States to examine this hypothesis. Dabelea et al [65] tested the hypothesis in six centers in the US (Cincinnati, Colorado, Hawaii, Seattle, South Carolina, Southern California) and found a significant relationship between BMI standard deviation score (SDS) and age at diagnosis only among patients with low C-peptide values at diagnosis. Evertsen et al [50] reported a significant inverse relationship between age at diagnosis and BMI SDS in their Wisconsin cohort. Thus, there is no consensus on the validity of the hypothesis among children and adolescents with T1D in the United States.
Traditionally, a patient with the classic symptoms of diabetes which include polyuria, polydipsia, and polyphagia who also has a family history of T2D, obesity, acanthosis nigricans and lack of both ketosis and diabetes-associated autoantibodies is considered to have T2D [68]. On the other hand, patients with T1D are usually thought to be thin, may present with ketosis, and have diabetes associated autoantibodies. [18] Patients with double diabetes possess the features of both T1D and T2D which could present siimultaneously at the time of diagnosis, or develop sequentially over time [18].
There is the need to formulate universal diagnostic criteria to facilitate the recognition of double diabetes either at the time of onset of hyperglycemia or in the course of the disease process. Pozzilli et al [16,31] recently introduced the concept of ‘metabolic load’ to describe the features of T2D and ‘autoimmune load’ to describe the features of T1D. They stated that in an obese child or adolescent with hyperglycemia, an increased ‘metabolic load’ and a reduced ‘autoimmune load’ are features of double diabetes (Figure 1). Based on this principle, they advanced the following clinical and biochemical guidelines to facilitate the diagnosis of double diabetes:
The presence of clinical features of T2D, hypertension, dyslipidemia, increased body mass index with increased cardiovascular risk, compared with children with classical T1D. Family history for T2D and T1D might be present.
The presence of a reduced number of clinical features typical of T1D, such as weight loss, polyuria and polydipsia, development of ketoacidosis; insulin therapy is not the first line of therapy, by contrast to the situation in subjects with classical T1D.
The presence of autoantibodies to islet cells, although with a reduced number and titer compared with T1D, and probably a reduced risk associated with the
The relationship between T1D, T2D and Double Diabetes, TID = type 1 diabetes, T2D = type 2 diabetes, FBG = fasting blood glucose, 2HPP = 2 hour post prandial glucose level; BMI = body mass index; Abs = antibodies
There is no consensus on the best therapeutic regimen for double diabetes. However, because insulin resistance is central to the pathophysiological mechanism of double diabetes, optimal management of this condition necessitates the addition of insulin sensitizers to the patient’s therapeutic regimen under appropriate clinical circumstances [18]. Intensification of lifestyle modification strategies should be encouraged to maintain normal weight and attenuate insulin resistance. Finally, because these patients require increased doses of insulin to maintain euglycemia, it is necessary to develop an insulin titration regimen that would ensure adequate glycemic control.
The availability of insulin analogs and diabetes monitoring devices has improved diabetes care around the world. However, according to recent studies, the prevalence of poorly-controlled diabetes in youth is still high [70]. This poor glycemic control predisposes the youth to acute and chronic complications of diabetes.
A report by the SEARCH for Diabetes in Youth Study group showed that a high proportion of youth with diabetes had high HbA1c values, with 17% of the youth with TIDM, and 27% of those with T2D showing poor control, defined as HbA1c ≥ 9.5% [70]. The American Diabetes Association target values for HbA1c in relation to age are as follows: 7.5-8.5% at age < 6 years, <8% at age 6-12 years, <7.5% at age 13-18 years, and <7.0% at age 19+ years [68]. Thus only a minority of children and adolescents meet the recommended glycemic targets.
The physiological factors that contribute to poor glycemic control in youth are in part related to the hormonal changes in puberty. Puberty is associated with relative insulin resistance, reflected in a two- to threefold increase in the peak insulin response to oral or intravenous glucose [71]; insulin-mediated glucose disposal is approximately 30% lower in adolescents than in prepubertal children or young adults [72]. This physiologic insulin resistance of puberty is of minimal consequence in the presence of adequate beta-cell function [73]. The cause of this physiologic resistance is likely the transitory increased activity of the growth hormone-insulin growth factor axis, as well as sex steroids, which coincides with the physiologic insulin resistance of adolescence [74] and act as counter-regulatory hormones. As a result of these physiological changes, insulin dosages are often increased to overcome the resistance to insulin, but metabolic control still frequently worsens during the later stages of pubertal development [37].
The increasing insulin resistance and deterioration of glycemic control in adolescents create a great need for alternative therapeutic strategies in adolescents with T1D. One such strategy is the addition of a drug that improves insulin sensitivity such as metformin, a biguanide that acts principally by increasing insulin sensitivity in the liver by inhibiting hepatic gluconeogenesis and thereby reducing hepatic glucose production [75]. Other minor mechanisms include decreasing fatty acid oxidation and intestinal glucose absorption [76], and increasing peripheral insulin sensitivity by enhancing glucose uptake in the muscles [77]. Metformin has mainly been used in adult patients with T2D and several studies have shown beneficial effects on body weight, blood lipid levels and metabolic control [78-80]. Randomized controlled trials with metformin in adolescents with T2D reported an improvement in fasting plasma glucose level [81]. However, there have been conflicting reports from studies in adolescents with T1D [75-77,82,83]. The benefit was transient in one study [83] and negative in another [82]. The main drawback of these studies was the small sample size and lack of reporting on long term benefit and safety of adjunctive therapy in many of them [84].
Evidence for the coexistence of insulin resistance and insulin deficiency in childhood-onset T1D adults has been demonstrated by the insulin-glucose clamp technique [85,86]. Furthermore, two randomized, placebo-controlled trials have investigated the role of adjunctive metformin therapy in adolescents with T1D. In a randomized placebo controlled trial in children with T1D who were treated for 3 months with adjunctive metformin, Sarnblad et al [77] reported a significant decrease in A1c from 9.6% to 8.7%(p<0.05) in the metformin group, compared to 9.5 to 9.2% (p=NS) in the placebo group. In another study, Hamilton et al [75] reported an HbA1c 0.6% lower in the metformin group than in the placebo group (P<0.035), after 3 months of therapy. Mean HbA1c at the end of the study was decreased by 0.3% in the metformin group, while it increased by 0.3% in the placebo group (p=0.03). Both studies reported no difference in mean body mass index and serum lipids in the metformin versus placebo group after 3 months of therapy. Hamilton et al [75] reported no significant changes in mean insulin sensitivity, measured by frequently sampled glucose after intravenous glucose tolerance test, after 3 months of metformin therapy in the metformin versus placebo group. Sarnblad et al [77], using hyperinsulinemic euglycemic clamp study, demonstrated no significant change in insulin sensitivity after 3 months between the groups, but they did report an increase in insulin sensitivity in the metformin group during the study (P<0.05). Hamilton et al [75] reported a significant change in the mean daily insulin dose in the metformin group in comparison to the placebo group after 3 months of metformin therapy of -0.14 vs. 0.02, P=0.01. However, Sarnblad [77] did not find a significant difference in the daily insulin dosage between the metformin and placebo groups after 3 months of therapy (1.1 vs. 1.3).
The two randomized, controlled studies by Hamilton and Sarnblad did not categorically recruit children and adolescents with double diabetes. This is important because this sub-set of diabetic youth is known to be insulin resistant and may require a careful titration of insulin doses. Adjunctive metformin therapy to achieve glycemic control may also be more effective in this subset of diabetes patients.
Furthermore, even though these randomized controlled trials were designed to investigate the effectiveness of adjunctive metformin therapy compared to insulin therapy alone, they were not designed to compare metformin adjunctive therapy to protocol-driven, optimized insulin therapy. Neither study demonstrated a strong head-to-head comparison of adjunctive metformin to patient-directed, treat to target insulin regimen to ensure optimal insulin delivery during the study. Such a comparison is critical because poor glycemic control contributes to insulin resistance [87] as there is an inverse relationship between glycemic control (as determined by HbA1c) and insulin sensitivity (estimated by glucose infusion rate during euglycemic-hyperinsulinemic clamp) [88].
In general, patients with double diabetes are overweight or obese and the resultant insulin resistance increases their insulin requirement [1]. However, in addition to requiring a high insulin dose, evidence suggests that many patients often do not have insulin doses titrated sufficiently to achieve target levels of glucose control [89,90]. These patients remain on suboptimal doses of insulin and fail to reach treatment targets [91]. In a recent study Blonde et al [91] demonstrated the efficacy of algorithm-guided, patient titration of once daily long acting insulin in normalizing HbA1c in adult patients with T2D. They conducted a 20-week, randomized, controlled, open label, multicenter, parallel-group study comparing the safety and efficacy of insulin detemir administered once daily in combination with oral antidiabetic agents when titrated to two fasting plasma glucose targets ( 3.0-5.0 mmol/L versus 4.4.-6.1 mmol/L) for the treatment of T2D in adults. In that study, fasting plasma glucose level decreased throughout the first 8 weeks of the study and then generally remained flat for each treatment group. The combined treatment groups achieved a mean HbA1c level of 6.9% at the end of the study. There were significant reductions in HbA1c in both titration groups: in the 3.9-5.0 mmol/L fasting plasma glucose target group, HbA1c values decreased from a baseline mean of 8% to 6.8% at 20 weeks. In the 4.4-6.1 mmol/L fasting plasma glucose target group, HbA1c values decreased from a 7.9% at baseline to 7.0% at 20 weeks. Overall rates of hypoglycemia episodes were low and were comparable between treatment groups: 7.73 and 5.27 events/subject/year for the 3.9-5 mmol/L and 4.4-6.1 mmol/L groups, respectively. Mean weight changes from baseline to the end of the study were small and did not differ significantly between groups.
Our group is conducting a randomized control trial to explore the role of protocol-driven treat-to-target regimen in children and adolescents with double diabetes. Given the rising prevalence of obesity in the general population we speculate that many children with T1D will eventually develop double diabetes. Thus, it is timely to devise an appropriate management protocol to treat this burgeoning sub-population. Our aim is to primarily study this group of patients to determine the role of protocol-driven, treat-to-target regimen alone or in combination with metformin therapy in their care. Metformin is approved by the Food and Drug Administration for use in children with T2D, and recently it has been recommended that metformin added to insulin therapy might be used in clinical practice in adolescents with T1D who are poorly controlled and show evidence of insulin resistance (double diabetes) as noted in T2D [84]. Given the conflicting reports on the efficacy of adjunctive metformin therapy in adolescents with T1D, this double blind, randomized, placebo controlled trial will demonstrate the effect of meformin on HbA1c reduction under optimized insulin titration regimen. Secondly, we will investigate whether a titrated insulin regimen alone would have a superior-, or similar effect to combined metformin and titrated insulin regimen in children and adolescents with double diabetes and how this modality of treatment compares to standard insulin therapy.
Blonde et al [91] demonstrated that self-titration regimens facilitate empowerment of patients, allowing them to become more involved in their treatment, which can result in improved glycemic control. Patient-directed insulin titration is increasingly important as health care practitioners often do not have the resources to advise patients with the frequency needed to effectively titrate their insulin doses to maintain euglycemia. Optimal patient empowerment through self-titration regimens is critical for the motivation to reach treatment targets.
The coexistence of both T1D and T2D in an individual should in principle denote an increased risk for the complications of both diseases [32]. Therefore, it is possible that these individuals are at higher risk for the microvascular and metabolic complications of T1D and the macrovascular complications of T2D [18]
The global pandemic of obesity in children and adolescents has resulted in a new expression of diabetes mellitus known as double diabetes. The entity encompasses the autoimmune load of T1D and the metabolic load of T2D. There is no consensus on the best therapeutic modality for this new expression of diabetes mellitus. However, optimal therapeutic options must address the coexistence of both metabolic and autoimmune components of diabetes mellitus in the patient. There have also been calls to revise the current classification of diabetes mellitus to take into account the surging prevalence of double diabetes in children and adolescents.
Olive oil occupied a key role in ancient Roman cooking and its culinary use expanded along with the Roman Empire, laying the foundation for what we now refer to as the Mediterranean diet. The culinary use of olive oil takes four basics forms: as a preservative, as a cooking medium, as an ingredient and as a condiment [1]. This chapter has a central focus on EVOO as a cooking medium.
As a cooking medium EVOO has a many functions, such as transferring heat from the heat source to the food, acting as a lubricant to prevent food from sticking to the cooking surface, adding flavour, crust and creating a more visually appealing look to the food [1]. It is an extremely healthy oil to use for all types of cooking and there is a lot of existing and emerging research related to the health benefits due to high levels of antioxidants (some of which are unique to EVOO) and the ability of the oil to enhance the health attributes of some ingredients once cooked [2, 3, 4].
However, myths related to cooking with EVOO have been prevalent from time to time, creating a lot of confusion for consumers.
Some of the prevalent myths related to cooking with EVOO are listed in Table 1.
Chemical reactions such as hydrolysis, oxidation, and polymerisation are prone to occur when edible oils are heated. Heating oils at high temperatures or for long periods of time can generate decomposition products such as free fatty acids (FFAs), alcohols, cyclic compounds, and polymers. Several factors can affect or influence these reactions, such as the type and quality of the oil, the kind of food used in cooking, the time and temperature of cooking and the food/oil ratio. These chemical reactions can affect both the nutritional value and the organoleptic properties of the oil. In addition, some of the products formed through oil decomposition may have adverse effects on human health. Physical changes in oil occur during heating and include increased viscosity, darkening in colour, and increased foaming. At the same time, the smoke point of the oil decreases [14, 15, 16, 17, 18].
There are two major properties of cooking oils commonly believed to dictate the behaviour of that oil, and subsequent safety when exposed to high cooking temperatures: smoke point and oxidative stability. While oxidative stability is a reasonable predictor of an oils’ ability to withstand heat, initial smoke point has proven to have very little correlation with the oils’ stability under heat while cooking, and the formation of polar compounds [5].
The smoke point is defined as the temperature at which a visible and continuous bluish smoke appears. At this point sufficient volatile compounds, such as FFAs and short chain oxidation products are emerging and evaporating from the oil.
The smoke point of an oil generally increases as the FFA content decreases, and the degree of refinement increases [19, 20].
The smoke point should not be considered a reliable measure of an oil’s stability and suitability for cooking for the following reasons:
The smoke point changes when an oil is heated, therefore it is not the same during the whole cooking process. The smoke point decreases faster when heating oils with a higher polyunsaturated fat content, such as in seed oils, than when heating oils with less poly-unsaturation and greater monounsaturated fat levels such as in EVOO [21].
The chemical fraction that mostly determines the smoke point of an oil is the FFA fraction which is under 1% of the total oil composition. This means that when the oil reaches the smoke point, only a minor part of it is evaporating and does not indicate the deterioration of the fat itself. In fact, studies have shown that the levels of FFA are not a reliable indication of deterioration of cooking fat [14].
When determining the smoke point, a small volume of oil is heated using a little brass cup in a confined and dark environment (Figure 1). Studies have shown that the smoke point rises when using a bigger container or a larger volume of oil in the presence of air. As a result, when cooking in a kitchen, smoke point temperatures could be greater than the ones that have been reported in the literature [22, 23, 24]. Thus, exact smoke point temperatures cannot be given [21, 24].
The standard procedure used to establish the smoke point relies heavily on the ability of the worker to determine visually the point at which the oil begins to smoke. This means that there can be analyst subjectivity when using this test procedure [19, 24].
The refining process used to produce other vegetable oils such as canola, peanut and rice bran oils involves high temperatures to neutralise FFAs. This gives the oils a higher smoke point but also produces secondary oxidation products which have been shown to have a detrimental effect on human health.
Smoke point determination equipment.
When heating oils, the process of fat oxidation is accelerated. Fat oxidation is where fat molecules interact with oxygen, leading to the potential formation of harmful compounds. Many authors agree that oxidative stability is the best predictor of the behaviour of oil during cooking [5, 16, 25].
Industrially and technically, the ability of an oil to withstand heat is measured by its resistance to the formation of polar compounds.
Non-volatile polar compounds, triacylglycerol (TAG) dimers and polymers are the main deterioration products of cooking oils. Several studies have associated these substances with certain types of cancer and neurodegenerative diseases including Alzheimer’s and Parkinson’s disease [26, 27]. However, this negative effect on health is related to the dose of these components. National and International legislation has identified that no more than 24–27% of polar materials in the final oil is a safe limit for human consumption [27]. These limits are made to ensure the oils used in cooking operations are safe for human consumption. When storing food after being cooked is required, then the recommended end point of polar compounds in the oil is <10% [14, 27].
Laboratory research is extremely important to understand the frying process and what the toxicological limits are to establish guidelines for consumers. However, it is important to highlight that sometimes the research completed with cooking oils has been pushed to the point of abusing the oils. These are extreme heating conditions and the results obtained do not always represent real-life situations, especially during home cooking. Therefore, proper judgement when drawing conclusions needs to be made. When cooking at home, normally one does not reach excessive temperatures for prolonged periods of time that deteriorate either the food or the oil in a way that makes them inedible or unsafe [27].
Edible oils are composed of triacylglycerols (> 96%) and endogenous minor components. It is generally agreed that the inherent composition of edible oils exerts considerable influence on their heating stability [15, 18]. In the interest of understanding better why we can, and we should cook with EVOO, it is important to review first its chemical composition. EVOO has a high level of oxidative stability when compared to other types of cooking oil and is less likely to undergo oxidation. This is primarily attributed to the following factors:
EVOO contains high levels of oleic acid, a monounsaturated fatty acid (MUFA) with just one double bond and low levels of linoleic and linolenic acids, which are polyunsaturated fatty acids (PUFAs) with multiple double bonds. This high MUFA/PUFA ratio confers good oxidative stability making it highly resistant to the production of harmful substances (such as polar compounds). The high levels of double bonds in PUFAs in seed oils make them sensitive to damage by heat [28, 29, 30].
The presence of natural antioxidants in EVOO, such as biophenols and Vitamin E, enhance the oil’s stability and resistance to oxidative degradation. Besides adding health benefits to the oil, these minor constituents boost EVOO’s stability reducing oxidative processes when the oil is heated [31, 32].
The phytosterols are a significant fraction of the unsaponifiable matter in EVOO. These substances add to the oil’s health profile. Some sterols have been shown to provide higher protection against lipid thermal deterioration by decreasing the production of TAG polymers [33]. These sterols are sometimes lost during oil refining and because EVOO does not require this manufacturing step, it retains high concentrations of phytosterols. It has been documented that phytosterols can be transferred to food while cooking, which could have a nutritionally positive impact on consumers [34].
In a comprehensive trial in Australia [5] conducted by an ISO 17025 accredited laboratory in 2018, ten of the most used cooking oils were selected from the supermarket to test their performance when heated. The oils tested were EVOO, virgin olive oil (VOO), olive, canola, rice bran, grapeseed, coconut, peanut, sunflower, and avocado oils.
Two different volumes of oils were heated in open pans (250 mL) for 20 minutes from 25–240°C and in deep fryers (3000 mL) at 180°C for 6 hours. Samples were collected at different intervals and then tested.
Authors specifically assessed the correlation between smoke point and other key chemical parameters related to an oils stability and likelihood to break down and form harmful compounds.
From this study, it was concluded that under different heating conditions, the generation of polar compounds with temperature and time was more pronounced for refined seed oils with higher initial values of smoke point, PUFAs, K232 and K270 (oxidative by-products). Reasonable predictors of how an oil will perform when heated have been oxidative stability, secondary products of oxidation, total level of PUFAs. EVOO was the most stable oil of those tested when heated, followed closely by coconut oil and other virgin oils such as avocado and high oleic acid seed oils. EVOO yielded lower levels of polar compounds and TFAs when compared with other oils.
This research also showed that an oil’s smoke point is not a relevant parameter to explain the oil’s behaviour when heated. Smoke point does not correlate with the stability of the oil during heating, as it showed a positive correlation with the increase in polar compounds (Table 2). That is to say that the higher the smoke point, the more polar compounds that are produced. PUFAs, K232 and K270 showed a positive correlation with polar compounds. Oxidative stability was negatively correlated with final content of polar compounds, demonstrating that a non-stable oil in terms of thermal degradation, will produce more polar compounds when heated (Table 2).
Myth | Assumptions based on the myth | Truth/reality based on scientific evidence |
---|---|---|
Smoke point is a relevant factor in determining how suitable an oil is to cook with. | EVOO is not suitable for cooking at high temperatures given its lower smoke point. | The utilisation of smoke point as an indicator of the ability of an oil to withstand heat, and to determine suitability for cooking is technically incorrect, and is not supported by scientific evidence. Recent evidence [5] shows that EVOO is the most stable oil when heated when compared to other edible oils with higher smoke points. Mediterranean cultures have used EVOO as their only source of cooking oil for centuries and their diet has the highest amount of scientifically proven health benefits [2, 6, 7]. |
Cooking with EVOO can ruin cookware, such as non-stick pans (e.g., Teflon coated pans). | EVOO could be damaging to cookware coating. | Although there is no published scientific evidence to support this, these beliefs are specifically supported by some cookware manufacturers’ specifications that oils with higher smoke points are more suitable for cooking with Teflon coated cookware [8, 9]. On the contrary, EVOO, like any other oil, acts as a lubricant, preventing the food from sticking to the pan [1]. Cooking with EVOO does not ruin non-stick Teflon coated pans at a different rate than other cooking oils. |
Heating olive oil will increase the amount of saturated or trans fats. | You cannot heat olive oil. | All oils will oxidise and hydrogenate to a minor degree when heated several times using high temperatures, such as those used in industrial frying processes [10]. It has been documented that olive oil is less prone to oxidation and hydrogenation when heated than other oils when heated because it is rich in monounsaturated fat [11, 12]. Cooking with EVOO does not produce significant traces of trans fatty acids. In fact, EVOO is less prone to hydrogenation than other vegetable oils. |
When you cook vegetables with EVOO, the vegetables lose antioxidants. | EVOO is not suitable to use when cooking vegetables. | This is incorrect. Recent evidence shows that when cooking with EVOO (including deep frying and sautéing), there is a resultant increase in total phenols (antioxidants) in the cooked food (particularly when cooking raw vegetables) [13]. Cooking with EVOO may in fact improve the nutritional properties of the food. |
Myths related to cooking with EVOO.
Initial Parameter | Correlation with final polar compounds levels (%) |
---|---|
Smoke Point | 83 |
Oxidative Stability | −65 |
FFA | −34 |
PUFAs | 74 |
UV Coefficient K232 | 80 |
UV Coefficient K270 | 54 |
Correlation between final polar compounds and initial oil’s chemical parameters.
These results are also supported by recent research carried out in New Zealand in 2019 [25]. The authors concluded that quality EVOO, in accordance with relevant olive oil standards, is the best cooking oil for use in the home from a stability and health viewpoint. These authors also recommended criteria to indicate an EVOO is stable for cooking:
Initial % free fatty acids (FFA) <0.2% (w/w as oleic acid)
Peroxide Value (PV) < 5.0 mEq/kg
Induction time in Rancimat >15 hours.
Total polar compounds after 8 hours heating at 180°C < 25%
p-Anisidine value after 8 hours at 180°C < 70
TFAs are formed during partial hydrogenation of oils. The interconversion from cis to trans requires a lot of energy (~65 kcal/mole), however the use of a high temperature or a catalyst can enhance the reaction [35]. Consumption of diets high in hydrogenated fat and/or TFAs has been shown to have an adverse effect on lipoprotein profiles with respect to cardiovascular disease risk [36, 37].
The formation of TFAs while cooking food using oil is closely related to the temperature and how many times oil is reused [38, 39]. Several European countries have determined that the frying oil temperature must not exceed 180°C. These measures not only contribute to decreased degradation of unsaturated fatty acids but also result in a lower formation of monounsaturated trans fatty acid (MTFAs) and polyunsaturated trans fatty acids (PTFAs) during frying.
Much research has been done to determine how typical cooking procedures used in food preparation affect TFAs formation in edible oils. Research suggests even applying normal and/or extreme temperatures when cooking does not significantly affect the amounts of TFAs in edible oils [40, 41]. Formation of minor amounts of trans-oleic acid, inferior to 0.2 g/100 g fatty acids was observed by [11, 12] for all the olive oil grades, which is lower than the trans amounts in other refined vegetable oils.
Recent research presented at the World Congress of Oils and Fats in 2020 [42] demonstrated that initially EVOO does not contain TFA and that the food TFA content decreased by approx. 70% or remained stable when using EVOO. The same behaviour was observed with oils: the lowest TFAs production was in EVOO in comparison with other vegetable oils.
Cooking with edible oils, such as deep frying, usually involves two phenomena. Firstly, when the oil, that acts as a heating medium to the food, reaches 100°C water starts to evaporate from the food. This in turn gives way to the oil being absorbed into the food which modifies the fatty acid composition of the food as it cooks. It has been proven that the fat content of the food after deep frying is more like the fat profile of the oil used to cook than the raw food itself [14]. In addition, although the antioxidant content is reduced somewhat during cooking many healthy substances still remain in EVOO and are absorbed by the food. The absorption of these antioxidants into the food gives the food a better nutritional profile. For this reason, the use of EVOO is a healthier option than using other oils with less bioactive components [13, 42, 43].
Frying is one of the oldest methods of food preparation. It improves the sensory quality of food by formation of aromatic compounds, attractive colour, crust and texture, which are all highly appreciated by consumers [44, 45]. The most common frying methods are deep-frying, being the food totally immersed in hot oil, and pan-frying, when the food is cooked in a pan with a little amount of oil [46, 47].
There is a higher degradation under pan-frying conditions for olive oil and other vegetable oils, that can be explained by the higher contact surface between the food and the oil, higher exposure to atmospheric oxygen, and lower temperature control under processing [46].
Frying with EVOO using a lower food:oil ratio presents lower total polar compound amounts than more unsaturated vegetable oils, and with apparently no interference by the presence of food [32, 48, 49]. Within olive oils, the higher the degree of polyunsaturation the higher the tendency for the formation of total polar compounds [50].
The volatile fraction formed during the heating process, apart from being important from the sensorial point of view, is rich in degradation compounds. The formation of low molecular weight volatile aldehydes has a clear dependence on the temperatures used, rather than frying time [51]. The high oleic acid content in olive oil, together with the presence of chlorophylls, pheophytins and carotenoids, seems to contribute to a reduced acrolein formation and lower amounts of toxic monoaromatic hydrocarbons, alkylbenzenes and alkenylbenzenes, in comparison with other vegetable oils with higher polyunsaturated acyl groups [51, 52, 53].
Furthermore, as mentioned previously, in comparison with other vegetable oils, the fried food is enriched with olive oil antioxidants, which improves the nutritional profile of the food [54].
Roasting with olive oil is common in both domestic and industrial food preparation in Mediterranean countries [55]. This procedure is highly prone to oxidation due to the higher surface area exposed to convention hot air and processing times. When comparing with other vegetable oils with a higher degree of unsaturation, olive oil is also more resistant to oxidation under these heating conditions [11, 56]. In opposition, the total polar compounds clearly increase with vegetable oils with higher unsaturation degrees such as sunflower and corn oil [57].
In general, heating olive oil using a microwave demonstrates an apparent higher oxidation when compared with conventional heating, despite being probably lower than those achieved with other vegetable oils [58]. Researchers have compared microwave and conventional heating (in an electric oven) in several vegetable oils including sunflower, high oleic sunflower and olive oil. Among the studied oils, the EVOO exhibited better performance against oxidation with both heating methods. This is mainly due to its composition, including minor compounds with antioxidant properties (phenolic compounds and tocopherols) and a lower percentage of linoleic acid [59]. Still, all studies were performed without the presence of food, meaning further studies using real processing conditions are required for correct inferences [15].
In 2019, Modern Olives Laboratory, an Australian oil specialist laboratory, conducted research to assess the suitability of various cooking oils, including EVOO, for use on Teflon coated (TC) pans.
To investigate the hypothesis of whether cooking with EVOO ruins pans, the researchers measured the release of elements and metals from the pans when separately heated with different oils. They used three different brands of TC pans. These pans were heated with an acidic solution of water vinegar (WV) both prior to and after 6 cycles of heating with different oils (EVOO, olive oil, canola oil, rice bran oil and grapeseed oil). The WV solutions were tested to study the release of various metals.
Combining all TC pans, the authors found no significant differences in the chemical elements content between the final WV solutions from TC pans treated with the different oils. This indicates there is no significant difference between the volume of metals released from the cookware when various cooking oils were used. Hence, the various cooking oils had no effect on the pans’ integrity and quality when cooking. However, differences of statistical significance for Ca, Cu, Fe, P, Zn and SiO2 were observed between the different TC pan types. Higher values of these metals were detected in the most expensive pan compared with the cheapest TC pan. For example, Ca average values (including initial and final treatment) in the most expensive pan were ~ 2.92 mg/L vs. ~1.75 mg/L in the cheapest pan and ~ 2.42 mg/L in the average price pan. When considering each brand of TC pan, phosphorus levels were significantly higher between treatments when using rice bran oil in the average priced TC pan (4.7 mg/L vs. 2.5 mg/L) versus a low- or high-priced TC pan. Silicon dioxide was not detected before treatment and significantly increased using olive (1.1 mg/L) and grapeseed (1.03 mg/L) oils only in the lowest priced TC pan.
After all treatments, no visual deterioration of any of the TC pans was observed. This investigation indicates that higher differences in metal leaching were between pans quality, rather than between the treatments with the different oils. In no case the use of EVOO lead to the release of significantly higher levels of metallic substances from the pan than when using any other oil.
Even though these results are limited considering the lifetime of the TC pan, they indicate no initial impact of the oils’ smoke point on the performance of the TC pan and that EVOO performs similarly to other oils under normal cooking conditions when it comes to TC pan degradation.
Sufficient research has been done to demonstrate that an oil’s smoke point is not a reliable measurement as an indicator of the ability of an oil to withstand heat, and to determine suitability for cooking. Reasonable predictors of how an oil will perform when heated are oxidative stability, secondary products of oxidation, and total level of PUFAs. EVOO has been demonstrated to be the most stable oil when heated given its unique chemical composition, which is rich in monounsaturated fatty acid and antioxidant content.
Experts have agreed that one of the most versatile and healthy oils to cook with is EVOO and many studies have linked it to better heart and overall health.
Food cooked with EVOO also had lower levels of undesirable products of degradation such as TFAs and polar compounds when compared with other vegetable oils such as canola, grapeseed, peanut, sunflower and rice bran oils, while deep-frying under normal cooking conditions.
Furthermore, based on scientific evidence EVOO does not deteriorate the coating when using Teflon cookware. On the contrary it acts as a lubricant to prevent food from sticking to the pans.
Selecting a true high quality EVOO, that is certified to meet EVOO grade and quality requirements is important to ensure high oxidative stability and safety while cooking.
We thank the Olive Wellness Institute (OWI) and Modern Olives Laboratory for their help during this work. To know more about OWI please visit https://olivewellnessinstitute.org/.
The authors declare no conflict of interest.
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Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). 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Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. 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His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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