Computational results of sediment yield for the location “Momina Koula”
\r\n\tOver the past few decades, there has been a rationalization for better classification of dystonia and paying more attention to understanding the different causes of dystonic movements from the advanced study of genetics, neurophysiology, and functional imaging in various forms of dystonia.
",isbn:"978-1-83768-478-6",printIsbn:"978-1-83768-477-9",pdfIsbn:"978-1-83768-479-3",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"1b011946aab26d18e0f4cfa61eb4249a",bookSignature:" Tamer Rizk",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12307.jpg",keywords:"Dystonia, Mutation, Genetic Variant, Exome Sequencing, Dopa-Responsive Dystonia, Rapid-Onset Dystonia-Parkinsonism, Myoclonus Dystonia Syndrome, Dystonia-Hemolytic Anemia, Wilson's Disease, Huntington's Disease, Neuroferritinopathy, Neurodegenerative Disorder",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 24th 2022",dateEndSecondStepPublish:"July 22nd 2022",dateEndThirdStepPublish:"September 20th 2022",dateEndFourthStepPublish:"December 9th 2022",dateEndFifthStepPublish:"February 7th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"20 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Dr. Rizk’s research focuses on various subspecialties in the field of pediatric neurology, specifically movement disorders and spasticity. He has many publications and is a member of the Editorial board of multiple reputable journals. He has presented his work at worldwide conferences and symposia and ran workshops for spasticity management and the use of the ketogenic diet in treating epilepsy. Dr. Rizk is a member of the ICNA, the INA, and the BPNA.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"170531",title:null,name:"Tamer",middleName:null,surname:"Rizk",slug:"tamer-rizk",fullName:"Tamer Rizk",profilePictureURL:"https://mts.intechopen.com/storage/users/170531/images/system/170531.jfif",biography:"Tamer Rizk, MD FRCPCH MBPNA (UK) MINA (USA) MICNA (SWE) is currently Consultant Pediatric Neurologist and a Professor of Pediatric Neurology in NB, Canada. Dr. Rizk’s research focuses on various subspecialties in the field of pediatric neurology, specifically movement disorders and spasticity. His research has been directed at recent advances in management modalities. Dr. Rizk studied Medicine at the Faculty of Medicine, Alexandria University, Alexandria, Egypt. His pediatric neurology training was shared between KSA and the UK. Subsequently, he completed a CESR in Paediatric Neurology from the UK. Dr. Rizk has many publications and he is a member of the Editorial board of multiple reputable journals in the field of pediatric neurology. He has presented his work in many worldwide conferences and symposia, and ran a lot of workshops for spasticity management and the use of the ketogenic diet in treating epilepsy.",institutionString:"Dalhousie University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"478200",firstName:"Dominik",lastName:"Samardzija",middleName:null,title:"Mr.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"dominik@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. Mauricio Barría",coverURL:"https://cdn.intechopen.com/books/images_new/6550.jpg",editedByType:"Edited by",editors:[{id:"88861",title:"Dr.",name:"R. Mauricio",surname:"Barría",slug:"r.-mauricio-barria",fullName:"R. Mauricio Barría"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9500",title:"Recent Advances in Bone Tumours and Osteoarthritis",subtitle:null,isOpenForSubmission:!1,hash:"ea4ec0d6ee01b88e264178886e3210ed",slug:"recent-advances-in-bone-tumours-and-osteoarthritis",bookSignature:"Hiran Amarasekera",coverURL:"https://cdn.intechopen.com/books/images_new/9500.jpg",editedByType:"Edited by",editors:[{id:"67634",title:"Dr.",name:"Hiran",surname:"Amarasekera",slug:"hiran-amarasekera",fullName:"Hiran Amarasekera"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3828",title:"Application of Nanotechnology in Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"51a27e7adbfafcfedb6e9683f209cba4",slug:"application-of-nanotechnology-in-drug-delivery",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/3828.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"49484",title:"Assessment of Reservoir Sedimentation Effect on Coastal Erosion and Evaluation of Sediment Removal Techniques for Its Reduction — The Case of Nestos River, Greece",doi:"10.5772/61459",slug:"assessment-of-reservoir-sedimentation-effect-on-coastal-erosion-and-evaluation-of-sediment-removal-t",body:'Coastal erosion constitutes a major environmental problem in many parts of the world. Especially in deltaic regions, the construction of dams in the river basin acts as an artificial barrier to the sediment supply to the river mouths and therefore the rates of shoreline retreat and sea level rise may exceed the corresponding rates of vertical shoreline accretion, resulting in the increase and in many cases the predomination of deltaic and coastal erosion. Over the last decades, many investigations have been directly or indirectly focused on the assessment of reservoir sedimentation and its effect on sediment yield reduction and coastal erosion, in the wider coastal regions of various rivers worldwide, using different investigation methodologies and techniques (e.g., [1]-[8]).
Nestos constitutes an important transboundary river, characterized by its great biodiversity. It flows through two European countries, Bulgaria and Greece, discharging into the Aegean Sea. It originates from Mount Rila (2716 m) in South Bulgaria, where Nestos River is known as Mesta. Its total length reaches 234 km and the river basin covers an area of 5749 km2, 130 km (<56%) and 2280 km2 (<40%) of which lies in Greek territory [9].
In the Greek part of the river, two hydroelectric dams, the Thisavros Dam and the Platanovrysi Dam, have already been constructed and started operating in 1997 and 1999, respectively. This implies a reduction of sediment yield at the outlet of the Nestos River basin and a corresponding disturbance of the sediment balance in the basin in general, which can result in coastal erosion. However, the reduction of the sediment yield at the outlet of the considered river due to the construction of these two reservoirs as well as the increase in the coastal erosion of the deltaic and the adjacent coastal regions have never been evaluated and correlated previously.
According to the authors’ best knowledge, the work that is presented in the first part of this chapter constitutes one of the first assessments of reservoir sedimentation effect on the coastal erosion for the case of the Nestos River delta and the adjacent shorelines, utilizing mathematical modeling, remote sensing techniques, and field surveying [10]. The main objectives are to evaluate the overall reduction of the sediment yield at the outlet of the river due to the construction of the two dams and to examine the resulting erosion/accretion response of the deltaic as well as the adjacent shorelines. For this purpose, the sediment yield at the outlet of the Nestos River basin before and after the construction of the two dams is calculated, through the application of a mathematical simulation model (RUNERSET – RUNoff ERosion SEdiment Transport). The model is initially tested against appropriate field measurements that are available in the literature. Moreover, a shoreline change monitoring methodology for the coastal region of the Nestos River delta and the adjacent shorelines is proposed, tested, and applied for the digital and detailed extraction of the shoreline position with respect to time, aiming to determine the erosion/accretion shoreline balance for two time periods that correspond to the periods before and after the construction of the dams. Finally, the mathematically calculated reduction of the sediment yield at the outlet of the river is correlated with the results from the application of the shoreline change monitoring methodology and some valuable conclusions and recommendations are drawn. The considered mathematical simulation model (RUNERSET) calculates the mean annual value of sediment yield, due to rainfall and runoff. The proposed model consists of three submodels: a rainfall-runoff submodel, a soil erosion submodel and a sediment transport submodel for streams. The coastal erosion/accretion monitoring data that were used in order to determine the shoreline evolution consist of remote sensing data from high-resolution satellite images (year 2002, considered period of construction/operation of the dams) and aerial photographs (year 1945, period before the construction/operation of the dams/reservoirs) as well as from high-resolution DGPS (Differential Global Positioning System) field measurements (year 2007, period after the construction/operation of the dams/reservoirs). It is calculated that the construction and operation of the considered dams have caused a dramatic decrease (about 83%) in the sediments supplied directly to the basin outlet and indirectly to the neighboring coast, and that this fact has almost inversed the erosion/accretion balance in the deltaic as well as the adjacent shorelines. Before the construction of the reservoirs, in the entire pilot study region, accretion predominated erosion by 25.36%, while just within 5 years of the construction/operation of the reservoirs, erosion predominates accretion by 21.26% [10]. Moreover, in the same part of this chapter, aiming to quantitatively investigate the dynamic evolution of erosion in the considered coastal region, a more recent shoreline (2013) was also extracted. For this purpose, additional DGPS field measurements were performed, following the same methodology and time period (spring) with the corresponding field measurements of the year 2007. Recording this more recent state of the coastline (2013) and comparing with the previous shorelines up to the perceived period of the construction and operation of the dams (2002) showed that erosion, in relation to the deposition/accretion that has been observed in the period 2002-2007, shows an increasing trend.
It has been estimated that every year almost 2% of the effective volume of reservoirs worldwide is lost due to sedimentation. This is an unavoidable fact, which however can be reduced, quantified, and incorporated into the design and operation of a reservoir [11]. The sediment management methods in reservoirs can be classified into three main categories: a) methods that minimize the inflow of sediment into the reservoirs, b) methods that minimize the accumulation of sediment in the upstream part of the reservoir and c) methods that maximize the overall sediment discharge that passes downstream of the reservoirs. The application of this last class of methods could serve as a possible treatment for the reduction of shoreline erosion, which has been mainly caused by the construction of the above-mentioned dams in the case of Nestos River. Two of the most widely applied methods of sediment removal from reservoirs are the processes of mechanical removal or dredging [11] and flushing [12]. In the work that is presented in the second part of this chapter, the dredging as well as the flushing of sediment from the reservoir of Platanovrysi, and its disposal in the subbasin downstream of the Platanovrysi Dam up to the Nestos River delta, are investigated as potential treatment methods of reducing coastal erosion ([13], [14]). For this purpose, the considered mathematical model (RUNERSET) was accordingly modified in order to incorporate these effects, and various scenarios of sediment management in the Platanovrysi Reservoir were simulated, while an assessment of the most effective and consistent month of the year for sediment flushing or dredging, as well as of the maximum transport quantity of the removed material was conducted. Finally, a comparison of the two methods takes place, concerning the maximum sediment quantities that reach the basin outlet, at the optimal for each method month of the year.
The overall findings and conclusions, arising from the work presented and discussed in this chapter, contribute to the need to thoroughly understand the direct effect of dam construction on coastal erosion. More specifically, the presented work constitutes one of the first attempts to quantify the disruption of the sediment balance in the delta of Nestos River due to the construction and operation of the Thisavros and Platanovrysi Reservoirs, considering simultaneously the impact of this disturbance on the erosion/accretion balance both at the river delta and the adjacent shorelines. Moreover, for the first time, an effort is made for the evaluation of the optimum periods and sediment management methods, aiming to increase the annual sediment that reaches the outlet of the Nestos River basin, and consequently to reduce erosion in the delta of the river and the adjacent shorelines. Finally, it is evident that the overall research methodology applied may constitute a quite useful tool for the further investigation of the effect of dam construction on the coastal erosion for other pilot application areas, throughout the world.
As mentioned previously in the introduction section of this chapter, the considered mathematical simulation model (RUNERSET) calculates the mean annual value of sediment yield, due to rainfall and runoff, and it consists of three submodels: a rainfall-runoff submodel, a soil erosion submodel, and a sediment transport submodel for streams.
By means of the rainfall-runoff submodel, the runoff depth for a certain rainfall depth is computed. It is a simplified water balance model [15], in which the variation of soil moisture due to rainfall, evapotranspiration, deep percolation, and runoff is considered. The basic balancing equation is:
where
The direct runoff depth
where
In the present study, two different methods were used for the estimation of the potential evapotranspiration
The following meteorological data are required for the application of the radiation method: mean daily temperature (oC), sunlight hours per day (hr/day), mean daily relative humidity (%), and mean daily wind velocity (m/s). These data were available in the Greek part of Nestos River basin. For the application of the Thornthwaite method, only mean daily temperature data (oC) are required, which were available in the Bulgarian part of the Nestos River basin.
According to the equations given above, apart from the meteorological data, the input data for the rainfall-runoff submodel are: monthly rainfall depth, altitude, latitude, soil cover – land use, and hydrologic soil group.
The soil erosion submodel is based on the assumption that the impact of droplets on the soil surface and the surface runoff are proportional to the momentum flux contained in the droplets and the runoff, respectively [19].
The momentum flux exerted by the falling droplets,
where
The original relationship of Schmidt for the momentum flux exerted by the droplets is valid for bare soils. Therefore, an additional factor is necessary to express the decrease of the momentum flux because of the vegetation. It is believed that the dimensionless crop and management factor
The momentum flux exerted by the runoff,
where
The available sediment discharge per unit width,
where
and
The critical momentum flux
where
The critical runoff rate
Equation (6) suggests the concept of critical situation characterizing the initiation of sediment motion on the soil surface.
The sediment supply
where
The additional input data for the soil erosion submodel, with reference to the rainfall-runoff submodel, are: mean slope angle of soil surface, subbasin area, soil cover factor, length of the main stream of the subbasins, roughness coefficient of soil surface, critical erosion velocity, water, and sediment density.
The sediment yield at the outlet of the main stream of the subbasin considered can be computed by the concept of sediment transport capacity by the stream flow. The following relationships are used to compute sediment transport capacity by the stream flow [20]:
where
Equation (9) was determined from the concept of unit stream power (rate of potential energy expenditure per unit weight of water,
The sediment yield
It is implied from the above relationships that only the main stream of each subbasin is considered, because numerous unavailable data for the geometry and hydraulics of the entire stream system would otherwise be required. Therefore, the additional input data for the stream sediment transport submodel, with reference to the foregoing submodels, concern the main stream of the subbasins: base flow, bottom slope, bottom width, bed roughness, diameter of suspended particles, grain diameter of bed material, and kinematic viscosity of water.
Finally, a sediment routing plan is necessary in order to specify the sediment motion from subbasin to subbasin.
For more precise calculations, the Nestos River basin was divided into 60 subbasins. In more detail, the basin of the Thisavros Reservoir (Bulgarian and Greek parts) was divided into 31 subbasins, the basin of the Platanovrysi Reservoir (Greece) into nine subbasins and the basin downstream of the Platanovrysi Reservoir into 20 subbasins. The outlet of the last basin is known as Toxotes outlet.
Subbasins/main streams map and soil cover map of the Nestos River basin
Available meteorological data (monthly rainfall data and mean monthly temperature data) from 22 meteorological stations in Greece and Bulgaria were used as input data for the simulation model. Various digital thematic maps were constructed from georeferenced background maps, for the accurate computation of the required input parameters. Indicatively, the subbasins and main streams map as well as the soil cover map are depicted in Figure 1.
However, other kind of thematic maps were also constructed and used such as a Thiessen polygons map and a geological map. The calculations were performed on a monthly time basis for each subbasin.
In order to validate the mathematical model predictions, sediment measurements (suspended load) for 53 years (1937-1989) that were available for the location “Momina Koula” [21] in the Bulgarian part of Nestos River (Figure 1), were utilized. According to the measurements, the mean annual suspended sediment yield for the considered time period is 202 t/km2 [21]. Bed load measurements were not available and therefore, the following assumption [10] was made: the ratio of bed load to suspended load at the outlet of a basin on an annual basis amounts approximately to 0.25. According to this assumption, the measured mean annual sediment yield at “Momina Koula” is 252.5 t/km2.
The mathematical model described in the previous section was applied to the basin corresponding to this location for the same time period [10]. The basin area is 1511 km2, which is about 30% of the entire basin area of the Nestos River. The results of the model application for the different years are given in Table 1.
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t
1937 | \n\t\t\t366 000 | \n\t\t\t1950 | \n\t\t\t278 500 | \n\t\t\t1964 | \n\t\t\t91 000 | \n\t\t\t1977 | \n\t\t\t85 500 | \n\t\t
1938 | \n\t\t\t300 500 | \n\t\t\t1951 | \n\t\t\t428 500 | \n\t\t\t1965 | \n\t\t\t276 500 | \n\t\t\t1978 | \n\t\t\t280 500 | \n\t\t
1939 | \n\t\t\t271 500 | \n\t\t\t1952 | \n\t\t\t374 000 | \n\t\t\t1966 | \n\t\t\t475 500 | \n\t\t\t1979 | \n\t\t\t315 000 | \n\t\t
1940 | \n\t\t\t447 500 | \n\t\t\t1953 | \n\t\t\t359 000 | \n\t\t\t1967 | \n\t\t\t107 500 | \n\t\t\t1980 | \n\t\t\t314 000 | \n\t\t
1941 | \n\t\t\t144 500 | \n\t\t\t1954 | \n\t\t\t786 000 | \n\t\t\t1968 | \n\t\t\t252 500 | \n\t\t\t1981 | \n\t\t\t200 500 | \n\t\t
1942 | \n\t\t\t313 500 | \n\t\t\t1955 | \n\t\t\t381 000 | \n\t\t\t1969 | \n\t\t\t634 500 | \n\t\t\t1982 | \n\t\t\t209 500 | \n\t\t
1943 | \n\t\t\t36 000 | \n\t\t\t1956 | \n\t\t\t458 000 | \n\t\t\t1970 | \n\t\t\t152 500 | \n\t\t\t1983 | \n\t\t\t68 500 | \n\t\t
1944 | \n\t\t\t327 000 | \n\t\t\t1958 | \n\t\t\t413 000 | \n\t\t\t1971 | \n\t\t\t511 500 | \n\t\t\t1984 | \n\t\t\t185 000 | \n\t\t
1945 | \n\t\t\t485 000 | \n\t\t\t1959 | \n\t\t\t274 000 | \n\t\t\t1972 | \n\t\t\t179 000 | \n\t\t\t1985 | \n\t\t\t239 000 | \n\t\t
1946 | \n\t\t\t338 000 | \n\t\t\t1960 | \n\t\t\t555 500 | \n\t\t\t1973 | \n\t\t\t318 000 | \n\t\t\t1986 | \n\t\t\t511 000 | \n\t\t
1947 | \n\t\t\t517 500 | \n\t\t\t1961 | \n\t\t\t160 500 | \n\t\t\t1974 | \n\t\t\t225 000 | \n\t\t\t1987 | \n\t\t\t288 500 | \n\t\t
1948 | \n\t\t\t72 000 | \n\t\t\t1962 | \n\t\t\t798 500 | \n\t\t\t1975 | \n\t\t\t55 500 | \n\t\t\t1988 | \n\t\t\t253 000 | \n\t\t
1949 | \n\t\t\t230 500 | \n\t\t\t1963 | \n\t\t\t705 500 | \n\t\t\t1976 | \n\t\t\t319 500 | \n\t\t\t1989 | \n\t\t\t7 500 | \n\t\t
Computational results of sediment yield for the location “Momina Koula”
The mean annual value of sediment yield at the basin outlet, according to Table 1, is 315 000 t or 207.9 t/km2. This means that the mathematical model underestimates the measured mean annual sediment yield by about 18%. However, taking into account the overall assumptions of the mathematical model as well as the complexity of the simulated process, these arithmetic predictions can be considered to be acceptable.
The relatively low deviation between computation and measurement results for the mean annual sediment yield at the location “Momina Koula” was an encouraging indication for the further application of the simulation model to other parts of the Nestos River basin. The following calculations were therefore performed for a time period of 11 years (1980-1990), which corresponds to the period before the construction and operation of the considered reservoirs:
Calculation of mean annual sediment amount inflowing into the Thisavros Reservoir from the Bulgarian part (3052 km2) and from the Greek part (804 km2) of the Nestos River basin ([10]; [22])
Calculation of mean annual sediment amount inflowing into the Platanovrysi Reservoir from the corresponding basin (405 km2, Greece) [23]
In a previous study [24], the mean annual value of sediment yield at the outlet of the Nestos River basin (Toxotes) was calculated. Due to the construction and operation of the considered reservoirs, the sediment yield originates mainly from the part of the Nestos River basin which lies downstream of the Platanovrysi Reservoir (840 km2, Greece).
The calculated values of the annual sediment yield for different years at certain locations of the Nestos River basin (Thisavros Reservoir, Platanovrysi Reservoir, and Toxotes) are summarized in Table 2.
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t
1980 | \n\t\t\t1 084 000 | \n\t\t\t184 000 | \n\t\t\t154 500 | \n\t\t\t366 000 | \n\t\t\t278 000 | \n\t\t\t2 066 500 | \n\t\t
1981 | \n\t\t\t968 000 | \n\t\t\t128 000 | \n\t\t\t128 500 | \n\t\t\t344 000 | \n\t\t\t588 000 | \n\t\t\t2 156 500 | \n\t\t
1982 | \n\t\t\t850 000 | \n\t\t\t312 500 | \n\t\t\t112 500 | \n\t\t\t409 000 | \n\t\t\t426 000 | \n\t\t\t2 110 000 | \n\t\t
1983 | \n\t\t\t309 500 | \n\t\t\t114 000 | \n\t\t\t32 500 | \n\t\t\t99 500 | \n\t\t\t73 000 | \n\t\t\t628 500 | \n\t\t
1984 | \n\t\t\t678 500 | \n\t\t\t360 500 | \n\t\t\t107 500 | \n\t\t\t277 000 | \n\t\t\t494 000 | \n\t\t\t1 917 500 | \n\t\t
1985 | \n\t\t\t991 000 | \n\t\t\t94 500 | \n\t\t\t127 500 | \n\t\t\t54 500 | \n\t\t\t131 000 | \n\t\t\t1 398 500 | \n\t\t
1986 | \n\t\t\t1 495 500 | \n\t\t\t613 000 | \n\t\t\t162 000 | \n\t\t\t303 500 | \n\t\t\t198 000 | \n\t\t\t2 772 500 | \n\t\t
1987 | \n\t\t\t1 021 000 | \n\t\t\t875 500 | \n\t\t\t131 500 | \n\t\t\t761 500 | \n\t\t\t673 000 | \n\t\t\t3 462 500 | \n\t\t
1988 | \n\t\t\t884 000 | \n\t\t\t357 500 | \n\t\t\t130 000 | \n\t\t\t241 000 | \n\t\t\t383 000 | \n\t\t\t1 995 500 | \n\t\t
1989 | \n\t\t\t73 500 | \n\t\t\t121 000 | \n\t\t\txx | \n\t\t\t192 500 | \n\t\t\t207 000 | \n\t\t\t594 000 | \n\t\t
1990 | \n\t\t\t545 500 | \n\t\t\t552 500 | \n\t\t\t46 500 | \n\t\t\t289 500 | \n\t\t\t64 000 | \n\t\t\t1 498 000 | \n\t\t
Mean value | \n\t\t\t809 000 | \n\t\t\t337 500 | \n\t\t\t113 000 | \n\t\t\t314 500 | \n\t\t\t331 000 | \n\t\t\t1 873 000 | \n\t\t
Computational results of sediment yield at various locations of the Nestos River basin
For these calculations, the major assumption is that all sediments inflowing into the reservoirs are deposited in the reservoirs, which represents the most unfavorable case regarding coastal erosion. According to Table 2, the mean annual value of sediment yield at the outlet of the Nestos River basin before the construction of the dams (mean annual value of sediment yield at the outlet of the entire Nestos River basin) is about 1.9x106 t, while after the construction of the dams (mean annual value of sediment yield at the outlet of basin downstream of the Platanovrysi Reservoir) this amounts to 0.33x106 t. Therefore, it is evident that the construction and operation of the considered reservoirs has caused a dramatic decrease, of about 83%, in the sediments supplied directly to the basin outlet and indirectly to the neighboring coast. Since Nestos River constitutes one of the main sediment supply sources for the west and east parts of the coastal region in the vicinity of its delta, it is expected that the calculated reduction in the sediment yield that reaches the Nestos River mouth will influence the seashore sediment balance, and it may result in a considerable increase in the erosion rates of the Nestos River mouth and the adjacent shorelines.
The adopted shoreline change monitoring methodology for the Nestos River delta and the adjacent shorelines was the use of available high-resolution satellite images from the QuickBird (QB) satellite archive and aerial photographs from the Hellenic Military Geographical Service (HMGS), in conjunction with high-resolution GPS field measurements of the region [10]. In more detail:
Use of ortho-rectified/georeferenced satellite images that were available in the QB archive for the extraction of the shoreline in the year 2002. The spatial resolution of these satellite images is 0.6 m per pixel. The proposed year was selected, as it was more close to the years 1997 and 1999 of the construction and operation of the considered reservoirs.
Use of high-resolution DGPS field measurements for the extraction of the shoreline in the year 2007, in order to obtain the shoreline state approximately a decade after the operation of the considered reservoirs. The accuracy of these field measurements can reach the order of few centimeters.
Comparison of the extracted shorelines between these 2 years in order to access a short-term shoreline evolution of the region that can be considered to be the period after the construction of the dams.
Ortho-rectification/georeferencing of available, old aerial photographs of the region from the year 1945 from the HMGS and extraction of an old shoreline, approximately 50 years before the construction and operation of the reservoirs.
Comparison of the extracted shorelines between the years 1945 and 2002 in order to access a long-term shoreline evolution of the region that can be considered to be the period before the construction of the dams.
In order to test the accuracy of the adopted shoreline change monitoring methodology, this was first applied to a small part of the total pilot study region (Figure 2). The proposed test part is composed by the mainland shoreline at the west of Nestos River delta extending from the Akroneri Cape until the Keramoti Bay.
Pilot study region for shoreline change monitoring and selected region for testing the accuracy and effectiveness of the adopted shoreline change monitoring methodology
The main steps of the utilized methodology are outlined in the following subsections.
In order to use a common working subbase, an ortho-rectified background of the wider geographical region was created using various available topographic maps from the HMGS. The merging and ortho-rectification of the proposed maps was conducted in ArcMap software from the ArcGIS 9 package, using as Ground Control Points (GCPs) a wide number of known, benchmark trigonometric points of the region that were available by the HMGS.
The ortho-rectification of the available old aerial photographs of the region and the digital extraction of the corresponding shoreline was conducted with the ArcMap software of the ArcGIS 9 package. The basic stages of the proposed procedure are summarized below:
The aerial photographs were scanned and digitally imported into the ArcMap database in order to be ortho-rectified in the EGSA 87 coordinate system, using as GCPs points that were both visible in the aerial photographs as well as in the ortho-rectified map background. A total number of 6-8 GCPs were used for each aerial photograph.
A surface analysis was then performed in the aerial photographs and automatic contours were generated.
The contour that corresponded to the dividing line between land and sea pixels was manually selected by visual inspection and digitally extracted as the shoreline position in the year 1945.
Figure 3 (a) illustrates the digitally extracted shoreline for the testing region (year 1945) superimposed on the corresponding aerial photograph where the adequate accuracy and the validity of the extraction method described above can be clearly seen.
The digital shoreline extraction from the ortho-rectified, high-resolution, satellite images of the region was also conducted using the ArcMap software of the ArcGIS 9 package. The basic stages are summarized below:
Ortho-rectified, QB satellite images of the pilot study region were selected and ordered from the archive database of GEOMED LTD, one of the authorized resellers of these images, in Greece.
The proposed 4-band satellite images were then imported into the ArcMap database in the EGSA 87 coordinate system and adjusted to the infrared channel.
The well-known “Natural Breaks (Jenks)” pixel classification method was then applied on the images, from the “spatial analyst” tool of the ArcMap software, in order to separate sea and land pixels.
Then a contour line was automatically inserted at the interface of the classified sea and land pixels and digitally extracted as the shoreline.
Figure 3 (b) illustrates the digitally extracted shoreline for the testing region (year 2002) superimposed on the corresponding satellite image, where the adequate accuracy and the validity of the extraction method described above can be clearly seen.
(a) Digitally extracted shoreline from the aerial photograph that corresponds to the test region (year 1945), superimposed on the aerial photograph. (b) Digitally extracted shoreline from the high-resolution satellite images that correspond to the test region (year 2002), superimposed on the satellite image
The DGPS field measurements were conducted using a high-resolution DGPS system that consists of two GPS receivers. A static receiver that was installed at various, known, benchmark trigonometric points of the region that were preinstalled by the HMGS and a rover (mobile) receiver which was used for the surveying of the shoreline in the field. The recorded data points from the rover receiver along the shoreline were then postprocessed and extracted in AutoCAD files in the EGSA 87 coordinate system and finally imported superimposed at the ArcMap database. The accuracy of the DGPS measurements according to the specifications of the proposed equipment was of the order of few centimetres. However, this was double-checked and verified using GCPs with known coordinates.
In the present subsection, quantitative and qualitative results from the application of the proposed methodology to the entire pilot study region are presented and discussed in detail. Figure 4 illustrates indicatively some stages of the application for the entire pilot study area.
(a) Digitally extracted shoreline from aerial photographs (year 1945) for the entire pilot study region, superimposed on the aerial photographs. (b) Digitally extracted shoreline from satellite images (year 2002) for the entire pilot study region, superimposed on the satellite images. (c) Digitally extracted shoreline from DGPS measurements (year 2007) for the entire pilot study region, superimposed on the common working background
In order to investigate the erosion/accretion balance between the years 1945 and 2002 (time period before the construction of the dams) and the years 2002 to 2007 (time period after the construction of the dams), polygons that represent eroded and accreted areas were extracted from the ArcMap database. These are illustrated in Figure 5 for the two different time periods, respectively. The boundaries of these polygons are defined by the nonintersecting parts of the two digitally extracted shorelines in each of the examined time periods.
Eroded/accreted areas for the time periods 1945-2002 and 2002-2007
The resulting erosion/accretion balance expressed in m2 as well as in percentages relative to the total area, is summarized in Table 3.
\n\t\t\t\t | \n\t\t|
Erosion area (m2) | \n\t\t\tAccretion area (m2) | \n\t\t
1335027.90 | \n\t\t\t2242207.82 | \n\t\t
Erosion percentage (%) | \n\t\t\tAccretion percentage (%) | \n\t\t
37.32 | \n\t\t\t62.68 | \n\t\t
\n\t\t\t\t | \n\t\t|
Erosion area (m2) | \n\t\t\tAccretion area (m2) | \n\t\t
374892.96 | \n\t\t\t243453.14 | \n\t\t
Erosion percentage (%) | \n\t\t\tAccretion percentage (%) | \n\t\t
60.63 | \n\t\t\t39.37 | \n\t\t
Areas of erosion and accretion in the pilot study region, for the time periods 1945-2002 and 2002-2007
As it can be observed, from the year 1945 up to the year 2002 and for the considered shoreline (total length of 25 km), the erosion was about 1335028 m2 (23421 m2 per year) and the accretion 2242208 m2 (39337 m2 per year), i.e., the overall balance of the eroded/accreted areas from 1945 to 2002, indicates that accretion is the dominant mechanism covering a total area almost 1.7 times bigger than the corresponding area of the eroded parts. In other words, accretion dominates erosion by 25.36%. On the other hand, examining the same shoreline region from 2002 to 2007, the erosion was about 374893 m2 (74979 m2 per year) and the accretion 243453 m2 (48691 m2 per year), i.e., the erosion mechanism dominates accretion by approximately 21.26%. Therefore, it can be concluded that the dramatic decrease in the sediments supplied directly to the Nestos River basin outlet and indirectly to the neighboring coast, due to the construction and operation of the considered reservoirs, has almost inversed the previous state regarding the erosion/accretion balance in the considered region, just within 5 years of the construction of the dams. This finding evaluates the direct effect of the construction of the Thisavros and Platanovrysi Dams, to the erosion increase in the coastal region of the Nestos River delta and the adjacent shorelines.
As mentioned previously, for the purposes of the present investigation it was deemed appropriate to also extract a more recent shoreline (year 2013), in order to perform a comparison with the shorelines of the years 2002 and 2007, aiming at the quantitative investigation of the dynamic evolution of the examined coastal region, from the shoreline erosion point of view [14].
For this purpose, additional DGPS field measurements were conducted, following the same methodology and time period (spring) with the corresponding field measurements that were conducted in the year 2007. This more recent shoreline (2013) consists of three subregions: the Akroneri Cape region, the Keramoti Bay region and the region in the vicinity of the Nestos River delta.
The erosion/accretion balance between the shorelines of 2002-2007, 2007-2013, and 2002-2013 is illustrated in detail for these three subregions (Akroneri Cape in Figure 6, Keramoti Bay in Figure 7, and Nestos River delta in Figure 8).
As it can be macroscopically observed from Figure 6, in Akroneri Cape region, the eroded areas (red color) dominate the accreted areas (green color) in each one of the examined time periods. Examining both the subsequent periods 2002-2007 and 2007-2013 as well as in total the period from 2002 (considered period for reservoir construction and operation) to 2013 (most recent situation), in comparison with the initially examined period (2002-2007), it is characteristic that as years are passing, areas that in the first period were under relatively severe accretion are suffering in the subsequent periods from quite noticeable erosion.
Erosion (red color) /Accretion (green color) balance at Akroneri Cape region
Erosion (red color) /accretion (green color) balance at Keramoti Bay region
Almost the same trend is also observed in the region of Keramoti Bay, as it can be concluded by comparing the same time periods as previously (Figure 7). In more detail, while in the initial time period quite big areas of erosion as well as accretion can be traced, in the subsequent time period the areas that were initially under severe accretion, are now subjected to light accretion or even under considerable erosion. Accordingly, the areas that were initially subjected to considerable erosion, present now a more intense shoreline retreat.
Erosion/accretion balance in the region of the Nestos River delta
Regarding the region in the vicinity of the Nestos River delta, despite the fact that the shoreline presents a more intense and dynamic evolution, also in this case the initially presented (2002-2007) erosion/accretion balance in the subsequent time period (2007-2013) has been disturbed, indicating an increasing trend in the areas that are subjected to erosion with respect to the areas that are subjected to accretion.
All the above macroscopic observations are quantitatively summarized in Figure 9, where the percentages of erosion and accretion for the two subsequent time periods as well as for the entire examination period are depicted for each one of the examined regions.
Erosion (red color) /accretion (green color) percentages for the considered time periods, at Akroneri Cape region (a), at Keramoti Bay region (b) and the Nestos River delta region (c)
As it can be observed in all three considered regions, the erosion percentage in the time period 2007-2013 shows a significant increase in comparison with the previous time period (2002-2007). At Akroneri Cape region, an increase in the areas subjected to erosion by just 4% is observed. On the other hand, in the regions of Keramoti Bay and Nestos River delta, the corresponding increase reaches 23% and 24%, respectively, within just 6 years. It is also characteristic that in the case of the Nestos River delta, while in the time period 2002-2007 an erosion/accretion balance is observed, in the subsequent time period erosion predominates accretion by a considerable percentage. All the above quantitative observations can lead to the conclusion that the predomination of erosion with respect to accretion, after the construction and operation of the two reservoirs (year 2002), shows a continuously increasing trend.
In this third part of the present chapter, the effect of sediment removal by dredging and flushing from the Platanovrysi Reservoir downstream is investigated, in order to evaluate the increase in the sediment budget that reaches the outlet basin, as this increase can contribute to the reduction of shoreline erosion. For this purpose, the previously validated and applied mathematical model (RUNERSET - RUNoff ERosion SEdiment Transport) is modified accordingly in order to take into account sediment dredging and flushing applications. The proposed modifications involve the addition of different amounts of eroded material (sediment) in the subbasin that lies directly downstream of the Platanovrysi Reservoir for dredging processes as well as the inclusion of a flushing discharge. In more detail, a parametric investigation is conducted using a wide series of simulated scenarios, aiming to identify the optimum periods that dredging and flushing can be applied in order to maximize the increase of the sediment that is transported and reach the basin outlet [13].
In order to investigate the possible contribution of the mechanical removal (dredging) of sediment from the Platanovrysi Reservoir, and its deposition in the subbasin downstream of the Platanovrysi Dam, the mathematical model RUNERSET [10] was accordingly modified. In more detail, the proposed modification involves the addition of different, eroded sediment amounts in Subbasin 7 (Figure 1) for specific months of each year, for the time period 1980-1990.
A total number of 888 simulations were conducted for the years 1980-1990 assuming the following scenarios: application of dredging in each month of each year and for various amounts of sediment removal. Initially, diagrams of the total annual amount of sediment that reaches the basin outlet, versus the amount of sediment that was removed by dredging from the Platanovrysi Reservoir, were constructed. Figure 10 illustrates indicatively these diagrams for two of the considered years.
Indicative results from simulated dredging scenarios for the years 1981 (a) and 1986 (b)
From these diagrams it is obvious that for dredging scenarios in specific months of the year, the total annual sediment amount that reaches the basin outlet is higher than the corresponding amount in the rest of the months. Therefore, the months of the year can be clearly classified as “effective” and “ineffective” for a dredging application. In more detail, from the overall analysis of the simulation results, it can be concluded that January, February, March, April, November, and December can be, in general, characterized as “effective” months, while for the time period from May to October (ineffective months), a potential dredging application would not alter significantly the annual sediment amount that reaches the outlet of the river. The month classification in “effective” and “ineffective” is summarized schematically in Figure 11 (a), where the additional annual amount of dredged sediment that reaches Toxotes outlet of the river (Figure 1), is plotted against the amount of sediment that was removed in the specific month of the year in each case, for the overall simulated scenarios.
(a) Effective and ineffective months for dredging application, (b) Result of dredging application during the effective months of the year (the data points represent the overall simulated scenarios)
It has also to be mentioned that for amounts of sediment removal up to 35000 tn and for dredging scenarios in the effective months of the year, the ratio of the additional sediment amount that reaches Toxotes outlet, to the removed sediment amount, is equal to unity. This indicates that, generally, up to a limiting value of 35000 tn of dredged sediment from the Platanovrysi Reservoir, in an effective month, all of this removed amount of sediment will reach Toxotes outlet. Moreover, from a certain amount of removed sediment and above, there is not any change in the amount of sediment that reaches the basin outlet. This indicates that there is a maximum transport quantity of dredged material that the Nestos River can transport up to the basin outlet. This limiting amount varies accordingly for each month. Therefore, it is vital to define the month of the year in which this sediment transport quantity is maximized. Figure 11 (b) indicates that the maximum value of sediment surplus that reaches the basin outlet, takes place if dredging is applied in November.
However, for November there are also a lot of simulations that resulted in a zero sediment surplus at the basin outlet (in some of the overall simulated years). This means that while the Nestos River can transport the maximum amount of sediment that reaches the basin outlet, if the dredging application is performed during November for a certain year, it is also possible in a different year that no sediment at all reaches the outlet. Therefore, an additional classification of the “effective” months to “consistent” and “inconsistent” must be conducted. According to the diagram of Figure 11 (b), the months January and April can be characterized as “consistent,” while February, March, November, and December can be characterized as “inconsistent.”
In order now to investigate the most “effective” and “consistent” month of the year for applying sediment dredging, between January and April, a direct comparison of these two months was conducted. For this purpose, the overall results from all the simulated years (1980-1990) and for all the amounts of dredged sediment were collected, for January and April. The quantitative analysis of the proposed simulation results indicated that the overall sediment dredging performance of these two months could be classified into three distinct parts. The first part refers to dredging scenarios with sediment removal up to 34400 tn, in which the performance of each month with respect to the amount of sediment surplus that reaches the basin outlet is the same, having a value of 100%. The second and third parts consist of dredging scenarios with sediment removal from 34400 tn up to 36150 tn and greater than 36150 tn, respectively. In these last two parts of the collected data, the performance of each month is different, having values also lower than 100%. Taking into account the fact that the Nestos River cannot in general transport to the basin outlet dredged sediment amounts greater than 35000 tn, the third part of the resulting data was neglected from the comparison process. For the proposed comparison, the mean value of the dredged sediment amount that did not reach the basin outlet was taken as the effectiveness criterion, while the corresponding standard deviation was used as the criterion for consistency. The overall analysis from the comparison between January and April is summarized in Table 4. It is obvious that April can be assumed as the most suitable month of the year for a dredging application to the Platanovrysi Reservoir. It is also worth mentioning that the sediment amount of 35000 tn, that is, the maximum amount of dredged sediment that can reach the outlet of the Nestos River, is equal to 2.46% of the mean annual sediment yield of the river at its outlet, before the construction of the considered dams, and the 10.95% of the mean annual yield of the river after the construction and operation of the reservoirs. Finally, this sediment amount also constitutes the 11.53% of the mean annual sediment yield that reaches the Platanovrysi Reservoir.
\n\t\t\t | \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t|||
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t||
34400 | \n\t\t\t27806 | \n\t\t\t6594 | \n\t\t\t34400 | \n\t\t\t0 | \n\t\t|
34625 | \n\t\t\t34626 | \n\t\t\t-1 | \n\t\t\t34625 | \n\t\t\t0 | \n\t\t|
34744 | \n\t\t\t27806 | \n\t\t\t6938 | \n\t\t\t34744 | \n\t\t\t0 | \n\t\t|
34825 | \n\t\t\t34825 | \n\t\t\t0 | \n\t\t\t34102 | \n\t\t\t723 | \n\t\t|
34903 | \n\t\t\t34902 | \n\t\t\t1 | \n\t\t\t34101 | \n\t\t\t802 | \n\t\t|
36150 | \n\t\t\t35238 | \n\t\t\t912 | \n\t\t\t36150 | \n\t\t\t0 | \n\t\t|
Mean value | \n\t\t\t34941.17 | \n\t\t\t32533.83 | \n\t\t\t\n\t\t\t | 34687 | \n\t\t\t\n\t\t |
Mean attribution [%] | \n\t\t\t– | \n\t\t\t93.11 | \n\t\t\t\n\t\t\t | 99.27 | \n\t\t\t\n\t\t |
\n\t\t\t | \n\t\t\t | Mean value | \n\t\t\t2407.33 | \n\t\t\tMean value | \n\t\t\t254.17 | \n\t\t
\n\t\t\t | \n\t\t\t | Standard deviation | \n\t\t\t3396.38 | \n\t\t\tStandard deviation | \n\t\t\t394.55 | \n\t\t
Comparison of effectiveness and consistency between January and March for dredging application
In order to investigate the possibility of minimizing shoreline erosion due to the construction of the proposed dams, with the application of flushing, the mathematical model RUNERSET was accordingly modified, in order to take into account the corresponding flushing discharge. Also in these series of simulations, the model was applied for the years 1980–1990. For the calculation of the flushing discharge, Equation (12) was used assuming that the sediment flushing discharge is known [11]:
where Qs is the removed sediment discharge from the reservoir during a flushing event (tn/s); S is the bottom slope along the flushing channel, assuming that the flow is uniform and therefore the slope of the energy line and the flow line coincide; and Qf: is the flushing discharge (m3/s).
In order to determine the optimum month of the year for the application of flushing in the Platanovrysi Reservoir, a series of simulations were performed with a sediment flushing discharge of 0.0135 tn/s (that corresponds to the value of 35000 tn) and for flushing events occurring in different months. The results are summarized in Table 5.
\n\t\t\t | \n\t\t\t\t | \n\t\t||||||||||
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t|
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t
\n\t\t\t\t | \n\t\t\t95.71 | \n\t\t\t73.78 | \n\t\t\t90.94 | \n\t\t\t93.72 | \n\t\t\t0.00 | \n\t\t\t99.99 | \n\t\t\t0.00 | \n\t\t\t0.00 | \n\t\t\t84.48 | \n\t\t\t90.86 | \n\t\t\t90.97 | \n\t\t
\n\t\t\t\t | \n\t\t\t99.99 | \n\t\t\t35,20 | \n\t\t\t100.00 | \n\t\t\t100.00 | \n\t\t\t0.00 | \n\t\t\t24.55 | \n\t\t\t83.59 | \n\t\t\t99.99 | \n\t\t\t0.00 | \n\t\t\t100.00 | \n\t\t\t100.00 | \n\t\t
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t
\n\t\t\t\t | \n\t\t\t34.26 | \n\t\t\t21.77 | \n\t\t\t24.06 | \n\t\t\t22,88 | \n\t\t\t21.46 | \n\t\t\t21.98 | \n\t\t\t21.58 | \n\t\t\t22.54 | \n\t\t\t27.61 | \n\t\t\t21.70 | \n\t\t\t21.55 | \n\t\t
\n\t\t\t\t | \n\t\t\t20.83 | \n\t\t\t20.91 | \n\t\t\t20.92 | \n\t\t\t0.00 | \n\t\t\t20.89 | \n\t\t\t20.83 | \n\t\t\t23.58 | \n\t\t\t23.68 | \n\t\t\t0.00 | \n\t\t\t20.84 | \n\t\t\t20.86 | \n\t\t
\n\t\t\t\t | \n\t\t\t21.40 | \n\t\t\t21.48 | \n\t\t\t21,78 | \n\t\t\t7.45 | \n\t\t\t21.46 | \n\t\t\t21.69 | \n\t\t\t22.43 | \n\t\t\t21.68 | \n\t\t\t21.61 | \n\t\t\t21.70 | \n\t\t\t21.55 | \n\t\t
\n\t\t\t\t | \n\t\t\t21.40 | \n\t\t\t21.48 | \n\t\t\t21.49 | \n\t\t\t21.56 | \n\t\t\t21.46 | \n\t\t\t21.69 | \n\t\t\t21.58 | \n\t\t\t21.68 | \n\t\t\t21.61 | \n\t\t\t21.70 | \n\t\t\t21.55 | \n\t\t
\n\t\t\t\t | \n\t\t\t20.83 | \n\t\t\t20.91 | \n\t\t\t20.92 | \n\t\t\t20.85 | \n\t\t\t20.89 | \n\t\t\t20.83 | \n\t\t\t20.72 | \n\t\t\t20.82 | \n\t\t\t20.75 | \n\t\t\t20.84 | \n\t\t\t20.86 | \n\t\t
\n\t\t\t\t | \n\t\t\t21.40 | \n\t\t\t21.48 | \n\t\t\t21.49 | \n\t\t\t21.56 | \n\t\t\t21.46 | \n\t\t\t21.69 | \n\t\t\t21.58 | \n\t\t\t21.68 | \n\t\t\t20.75 | \n\t\t\t0.00 | \n\t\t\t21.55 | \n\t\t
\n\t\t\t\t | \n\t\t\t92.56 | \n\t\t\t0.00 | \n\t\t\t68.36 | \n\t\t\t99.15 | \n\t\t\t97.48 | \n\t\t\t99.99 | \n\t\t\t97.59 | \n\t\t\t13.68 | \n\t\t\t99.91 | \n\t\t\t0.00 | \n\t\t\t97.45 | \n\t\t
\n\t\t\t\t | \n\t\t\t0.00 | \n\t\t\t0.00 | \n\t\t\t0.00 | \n\t\t\t81.18 | \n\t\t\t100.00 | \n\t\t\t99,99 | \n\t\t\t99.88 | \n\t\t\t0.00 | \n\t\t\t0.00 | \n\t\t\t94.00 | \n\t\t\t14.58 | \n\t\t
Results from simulations of flushing scenarios for different months of the year
It is obvious that the optimum month for the application of a flushing event, in order to maximize the overall flushed sediment amount that reaches the basin outlet, and therefore decreases the indirect shoreline erosion, is January and not April (as in the corresponding investigation for the application of dredging). However, April is found to be the second most effective month. In the literature it is stated that in order to maximize the amount of sediment that is removed from a reservoir and therefore restore its storing capacity, a flushing event will be more effective if it occurs at the beginning of the ice melting period [11]. Therefore, from this point of view, April could be characterized as the optimum month of the year for the application of a flushing event.
In order to calculate the river’s maximum transport quantity of flushed sediment at the outlet of its basin, additional scenarios of continuous through each year flushing events were simulated. For this purpose, the mathematical model RUNERSET was further modified in order to take into account sediment flushing discharge equal to 0.1 tn/s, a value much greater than the previously identified critical value of 0.0135 tn/s. From the analysis of the results it is found that the Nestos River could transport to the basin outlet approximately 200000 tn of additional sediment, if the flushing of sediment was applied continuously during the whole year. It is worth mentioning that this amount constitutes the 62% of the mean annual sediment yield today.
Taking into account that the application of flushing could be more effective, at least from the point of view of limiting shoreline erosion, during certain months of the year (time period from November to April), additional continuous flushing scenarios were simulated for the period of the six more effective months of the year for each of the considered years (1980-1990). The overall results are summarized in Figure 12.
Results from simulated flushing scenarios
Examining Figure 12, it can be concluded that in the case that the continuous flushing event happens during the six of the most effective months of the year, the amount of sediment that reaches the basin outlet of the Nestos River reaches the 76.5% of the corresponding amount in the case of continuous flushing throughout the whole year. Moreover, in the case that the sediment flushing event is applied only during January the amount of sediment that reaches the outlet constitutes the 17.35% of the maximum possible amount (continuous flushing throughout the year). This amount is also equal to the 73.5% of the amount that would reach Toxotes outlet, in the case of a continuous flushing event during the noneffective months of the year (period from May to October).
In order to select the optimum of the two examined methods, a comparison was conducted by collecting the maximum amount of sediment that reaches the basin outlet of the Nestos River, that are attributed, if each method is applied in its optimum identified month of the year; April for the application of mechanical sediment removal, and January for the application of sediment flushing.
In order to calculate these quantities, a sediment discharge (dredging/flushing) greater than the previously used values of 35000 tn for the case of dredging and 0.0135 tn/s for the case of flushing was assumed. In more detail, the mathematical model was further modified in order to take into account a sediment discharge of Qs=289200 tn and qsf=0,1 tn/s, since it was proven that for values generally above 35000 tn (approximately 0.0135 tn/s for the case of a flushing event with a duration of 30 days), the results of the simulations did not change. The results of the proposed comparison are summarized diagrammatically in Figure 13.
Comparison between dredging and flushing
It can be seen that flushing seems to perform slightly better than dredging but in a degree that cannot be chosen as the optimum method. Therefore, in order to choose the optimal method for the aim of the present investigation, other criteria such as technical difficulties in their application as well as cost of application should be taken into consideration.
Coastal erosion that is generated by the reduction of the annual sediment yield at river outlets due to the construction of dams constitutes one of the main environmental problems in many parts of the world. Nestos is one of the most important transboundary rivers, characterized by its great biodiversity. The Nestos River flows through two European countries, Bulgaria and Greece, and discharges its water into the Aegean Sea. In the Greek part of the river, two dams, the Thisavros Dam and the Platanovrysi Dam, have already been constructed and started operating in 1997 and 1999, respectively. The construction of the dams implies a reduction of sediment yield at the outlet of the Nestos River basin and the alteration of the sediment balance of the basin in general, which results in coastal erosion.
The present chapter deals with the assessment of reservoir sedimentation effect on the coastal erosion for the case of the Nestos River delta and the adjacent shorelines, through mathematical modeling, remote sensing techniques, and field surveying. The mathematical model is applied for the estimation of the sediment yield reduction at the outlet of the river due to the subsequent sediment accumulation within the reservoirs, while a shoreline change monitoring methodology is applied for the estimation of the alteration of the erosion/accretion balance in the wider coastal region of the Nestos River delta, examining the proposed balance in two different time periods, before and after the construction of the dams.
The mathematical model results indicate that the construction of the considered dams has caused a dramatic decrease (about 83%) in the sediments supplied directly to the basin outlet (delta) and indirectly to the neighboring coast. Comparing the overall balance of the eroded and accreted areas in the region, before and after the construction and operation of the reservoirs, it can be concluded that the decrease in the sediments supplied directly to the Nestos River basin outlet and indirectly to the neighboring coast, has almost inversed the previous situation (where accretion predomin;ated erosion by 25.36%), just within 5 years of the construction of the reservoirs, with erosion now predominating accretion by 21.26%. The extraction of a more recent shoreline and the corresponding comparison with the previously identified shoreline states clearly indicates a continuously increasing trend in the predomination of erosion in relation to accretion.
Based on the above, it emerges that the construction and operation of the Thisavros and Platanovrysi Reservoirs have significantly increased coastal erosion in the Nestos River delta and the adjacent shorelines. This fact, together with the anticipated rise of sea level, may pose a great problem to the coastal area resources, threatening the local communities and ecosystems of the considered region. Therefore, it is necessary to further investigate the sediment budget within the estuarine and the adjacent coastal systems and to further monitor erosion/accretion trends of the region for the coming decades.
In the present chapter also, a previously validated and applied mathematical model is modified accordingly in order to take into account the application of sediment dredging and flushing in a reservoir of river hydrological basin. The modified model is applied for the case of the Nestos River (Greece) in order to identify the optimum sediment removal scenario in a certain reservoir (Platanovrysi Reservoir) upstream of the considered river outlet (Toxotes outlet), in order to maximize the amount of sediment that reaches the delta of the river. In more detail, a wide series of parametric simulation scenarios is performed, aiming to identify the optimum periods that the dredging and flushing can be applied. From the overall analysis of the simulation results, a definite classification of the months into “effective” and “ineffective” as well as into “consistent” and “inconsistent” with respect to the total amount of removed sediment that reaches the basin outlet is made. It is also found that the considered river has a maximum transport capacity of the removed material, regardless of the further increase of the dredged and/or flushed sediment capacity from the identified limiting value. A comparison between the two considered methods identified flushing to be slightly more effective than dredging.
Finally, the overall results of the present investigation indicate that the proposed modified mathematical model can serve as a quite effective and useful tool that can be applied for similar investigations at various river basins worldwide and it could also be incorporated into the early design stages of new reservoirs that are going to be constructed, estimating the amount of sediment discharge that needs to pass through the reservoir in the downstream part of the river basin in order to minimize the unavoidable deltaic and adjacent shoreline erosion.
The authors would like to acknowledge the financial support from the Research Project, INTEREG IIIC BEACHMED-e, “Strategic management of beach protection for sustainable development of Mediterranean coastal zones.”
Many procedures have been described throughout history in an attempt to increase lost tissue volume: dermo-fat grafts, omental free flaps, and musculoskeletal flaps, to name a few.
\nThe history of autologous fat transfer began in Europe with Neuber presenting his first fat transfer work at the 22nd Congress of the German Society of Surgery in 1893 [1], followed by Mojallal [2], Lexer [3], and Rehn [4] who described its use in a variety of procedures including thoracic and abdominal surgeries, breast surgeries and the field of neurosurgery and orthopedics, within the so-called “open-air” era - before liposuction (1889–1977).
\nBrunning was the first, in 1911, to inject fat into the subcutaneous tissue for augmentation [5]. This technique continued to be promoted as an alternative to resolve depressive areas. Without a doubt, its incorporation into the field of plastic surgery is where it has had its maximum development.
\nThe first attempts consisted of excising fatty tissue and placing it in small pockets in the subcutaneous layer. In the 50s, Peer observed that by placing small portions, at least 50% of their initial volume was lost in the long term and that this would depend mainly on early anastomosis of the recipient and donor vasculature, thus describing the theory of survival of fatty tissue grafts. It was established that the number of viable adipocytes at the time of graft placement directly correlates with the final volume that survives [6].
\nThe concept of absorption of fat grafts began practically from the moment of its use. Due to this, throughout its development, different theories arose that tried to explain what happened with transplanted fat [7, 8].
\nFor some time, fat transfer lost popularity. This led to the search for other alternatives, such as silicone, polymers, and hydroxyapatite crystals. It was in 1980 with the appearance of liposuction when the trend of obtaining fat for grafting was renewed [9]. From our perspective, we consider that different stages have contributed to the boom in autologous fat transfer in the field of cosmetic and reconstructive surgery. Ironically, during the development and refinement of liposuction techniques, the collected fat was thrown away. The question soon arose,
In 1986, Fournier [10] and Illouz [11] presented modifications in the technique for obtaining fat through aspiration syringes. Coleman in 1994 introduced his technique, perfectly describing the steps for sampling, purification by centrifugation, and transfer (reinjection), which he later called: Lipostructure®, warning that any traumatic act to obtain fat should be avoided, thus dividing the times: “unpurified” (With the discovery of liposuction 1977–1994), and “purified or atraumatic” (after the descriptions of Roger Coleman from 1994 to date). The literature has described that fat tissue grafts can cause a lasting correction; however, it has also been documented that fat undergoes multiple manipulations in its reinjection process, which affects its survival [12].
\nVerderame described that the surgeon had to compensate for this “shrinkage” by transplanting a greater amount of fat than required, hoping that the initial desired result with this “overcorrection” would equalize with subsequent reabsorption [13].
\nThis natural evolution on the improvement of the liposuction technique included improvements in equipment (suction machines and cannulas) and scientific bases to better understand the metabolism of adipocytes, their viability, and performance, and permanence over time [14, 15, 16].
\nThere are reports in the literature that compare the benefits of centrifugation, decantation, and washing of fat tissue, in an attempt to ensure the best viability of adipocytes and, therefore, better permanence.
\nIn a recent systematic review, Zhou et al. evaluated graft survival based on technique. The authors reported a statistically significantly higher facial fat graft survival rate of 71% in the cell-assisted lipotransfer group compared to 52% in the control group (standard fat grafting) [17].
\nFrom the beginning of stem cells obtained from adipose tissue, their potential therapeutic use was already envisioned at the level of tissue engineering and cell biology [18]. Matsumoto et al. in 2006, [19] described a technique called cell-assisted transfer (CAL). This technique consists of autologous transplantation of adipocytes enriched with stem cells derived from fatty tissue. Enzyme digestion is achieved using collagenase. With favorable culture media and different centrifugation steps, the stromal vascular fraction (SVF) is obtained. The SVF contains; stromal cells, endothelial progenitor cells, preadipocytes, ASCs, etc. In an adipogenic environment, ASCs can directly differentiate into adipocytes and contribute to volumetric restoration. They also promote graft survival through angiogenesis and the release of growth factors [20]. Yoshimura [21] described the use of this technique in cases of facial lipoatrophy and post-reconstruction breast augmentation and described the technique for obtaining the ASCs.
\nThe current use of fat transfer to replace volume or camouflage soft tissues is an increasingly popular method in plastic surgery, especially in craniofacial surgery. Due to our current globalized and increasingly competitive environment, it is undeniable that in the field of esthetic surgery, volumetric lipoinjection with adipose stem cells as facial profiling or combined with facial rejuvenation surgical procedures has great acceptance.
\nThe ideal patient for this procedure is one with a volume deficit due to soft tissue atrophy. Multiple pathologies have soft tissue hypoplasia as a common characteristic. Hemifacial microsomia is one of the most frequent abnormalities of the craniofacial complex [22]. Progressive hemifacial atrophy or Parry-Romberg syndrome is characterized by a progressive deformation and reduced soft tissue volume on one side of the face. It is also accompanied by trigeminal neuralgia, alopecia areata, and eye alterations. This condition can benefit from the transfer of stem cell-enriched fatty tissue [23, 24].
\nWe have recently described an alternative for postoperative cranioplasty for craniosynostosis. A specific population of these patients develops asymmetries categorized as depressions, particularly in the frontoorbital and temporal region, which are camouflaged using volumetric lipoinjection of adipose stem cells. This maneuver provides a volumetric effect and improves the inherent characteristics of the skin. All this contributes to a more harmonious facial appearance [25].
\nIts use has also been described in mild volumetric deficits of the middle and lower facial third secondary to skeletal fractures [26], even a camouflage option in patients with mild orthognathic alterations, such as micrognathia and microgenia [27]. We have used this alternative technique for more than a decade in our Craniofacial Surgery Clinic. In general, we use volumetric adipose stem cells in a wide range of disorders of the craniofacial complex, such as syndromes with a common characteristic, soft tissue hypoplasia, asymmetries secondary to facial skeletal trauma sequelae, and asymmetries due to craniosynostosis sequelae. Logically, this technical variant is also widely used to complement facial rejuvenation procedures or as an isolated facial profiling procedure.
\nCraniofacial malformations have a certain degree of psychosocial involvement, and children, particularly at an early age, are vulnerable to comments, ridicule, and harassment related to their appearance. Therefore, we consider it essential to provide an esthetic balance that promotes better facial symmetry. This is highly relevant since children at this stage are in the full development of their image, identity, and personality; hence, we consider that it is a priority to favor an adequate environment that facilitates greater self-esteem and better psychosocial development and integration. In some instances, it has a positive result in school performance [28].
\nThe surgical protocol should always include a complete medical history and an analysis of the degree of deformity to estimate the volume to be replaced. Also, photographic controls to assess its evolution in the medium and long term. Informed consent must be obtained.
\nBefore starting the procedure, a tracing is made on the preoperative images to better estimate the required volume, the mini-approaches necessary for its application, and a projection of the desired result.
\nThe lower abdomen of each patient is evaluated as the donor area of choice. Other areas may be the lower back and thighs since, in pediatric patients, the availability of abdominal fat may be limited.
\nAn oral dose of cephalexin is indicated the day before surgery and will continue for 4 days after. In pediatric patients, the procedure is performed under general anesthesia.
\nThe lower abdomen is infiltrated with a tumescent solution (0.25 mg of epinephrine in 250 mL saline solution) to perform fat aspiration. The ratio of infiltration is 1 mL of solution per 1 mL of harvested fat. We perform fat collection using a blunt-tipped #20 1-mm sharpened holes cannula 10 cm long and 2.5 mm in diameter attached to a 10-mL Luer-lock syringe. According to the areas to be treated and their degree of deformity, the average number of syringes usually collected is 2 to 3. In adults, for facial esthetics, it varies from 3 to 6.
\nThe extracted fat is separated into two samples, one is used for the isolation of ASCs, and the other will be enriched with the ASCs. The second sample is processed according to the Coleman protocol [12]. The isolation of the ASCs is carried out according to the technique described by Yoshimura [20]. It is important to point out that, in our beginning, the protocol for obtaining and isolating stem cells was in accordance with what was previously described. We currently treat fat in a simple way. In this way, we obtain 3 types of fat grafts: Mini-fat grafts (where adipocytes provide an average of 85% of the cell volume), Micro-fat grafts (average volume 50%), and Nano-fat grafts (virtually no adipocytes and a higher cell concentration of elements of the stromal vascular fraction), very similar to that described by Tonnard et al., however, with some variants [29].
\nOnce the fat has been collected with 10 ml syringes for mini-grafts, it is centrifuged for 1 min at 3000 rpm, and the infranatant fluid (composed mainly of tumescence fluid, blood, detritus, free fatty acids, etc.) is eliminated. We then connect a 2.5 mm diameter female-to-female transfer device at one end of the syringe, and on the other end, we connect 1 and 3 mL Luer lock syringes, ready to be filled and injected.
\nFor micro-grafts, the centrifugation and obtention process is similar. Afterward, the syringes are connected to another 10 ml Luer lock connector through the transfer device and are passed to the empty syringe “round trip” 5 times. The product is centrifuged again for 1 min at 3000 rpm, the infranatant is eliminated, and the cell conglomerate is transferred to 1- and 3-mL syringes ready to be injected.
\nMini and micro-fat injections are performed with short and long malleable fine cannulas, 1.5 to 2 mm in diameter. The process to obtain nano-fat is also similar to the previous one, with the difference that the fat is emulsified by making 30 “round trip” passes, with a 1.5 mm transfer. The syringes are then centrifuged for 1 min at 3000 rpm. Injections are performed with short and long, fine malleable cannulas, 1.5 to 2 mm in diameter.
\nLogically, we use mini-graft and micro-graft for volumetric increases. In nano-grafts, adipocytes are practically destroyed; therefore, they do not provide volume, and it has been shown that they have a higher concentration of ACSs with a vast potential for cell regeneration [30]. We use them to enrich the mini and micro-graft, and for injection into the subcutaneous and intradermal stratum (with 23-to-27-gauge needles) and to improve the inherent characteristics of the skin such as shine and texture due to the thickening of the dermis, moisturizing, and better contraction quality. It even better unifies the natural tone of the skin. All this provides a more youthful appearance of facial expression. We have recently also used nano-grafts to improve the appearance of tear trough, dark circles of the eyelids, and camouflage scars in general.
\nWe use 3-mL syringes and a 2-mm blunt-tipped cannula for lipoinjection. The micro-approaches to be made will depend on the area to be injected. We make these incisions initially with a 22-gauge needle. The area to which we will have access should be considered when performing our approaches to achieve a uniform “fan-shaped” distribution of the entire area to be lipoinjected and keep the cannula tip in mind (Figure 1).
\nIntraoperative view of the lipoinjection of adipose stem cells. (A) Glabellar approach. (B) Temporal approach (behind the hairline).
The final step consists of manual manipulation and remodeling of the injected fat, and in some cases, removal of excess grafted fat through the entry site. We use a 6–0 nylon suture to close the micro-approaches and 4–0 nylon for the scalp. The sutures are removed on the 4th or 5th postoperative day.
\nThe patient is a 35-year-old man with no previous medical history, diagnosed with progressive right hemifacial atrophy of 10 years evolution and 5 years with a stabilized condition. On examination, alopecia was found in the parietal and temporal region, together with subcutaneous tissue atrophy of the temporal region and the right midface, tooth loss, decreased range of motion of the temporomandibular joint, and trigeminal neuralgia. Three-dimensional (3D) reconstruction computed tomography showed the absence of the temporomandibular joint and a significant reduction of tissue volume in the affected side.
\nInfiltration with enriched autologous fat containing ASCs reduced the severe depression of the frontotemporal region and provided better volume and symmetry. An acceptable improvement of the malar prominence and cheek was also achieved, with greater volume and projection on the front view and profile. From its angle to the chin, the mandibular contour was redefined, achieving a better balance; even the neck base benefitted volumetrically. It is important to point out the permanence of the fat graft in the lips, which allowed the teeth to be hidden because of increased lip volume. The graft’s permanence remained stable in all the injected areas, even in the nasolabial folds and lips, which are areas of maximum mobility and reabsorption [24] (Figure 2).
\n(A, C, E) preoperative view. (B, D, F) postoperative view 12 months after lipoinjection enriched with stem cells and elements of the stromal vascular fraction.
A 4-year-old male diagnosed with anterior plagiocephaly, which was initially treated with cranioplasty and frontal bandeau at the age of 12 months. A defect is observed in the frontal glabellar region. A fat transfer was performed to achieve symmetry in both regions through a minimally invasive approach [31] (Figure 3).
\nIntraoperative view. (A) Glabellar lipoinjection was performed in a fan shape until adequate symmetry was achieved. (B) the treated left area. (C) both treated areas.
Congenital bands are compressive rings with a groove of different depths that can be partially or wholly circular at one end.
\nIts etiology remains unknown. Its rupture has been described through the use of Z- and W-plasty and excision and primary closure; However, new alternatives to its treatment have recently been described.
\nA 36-year-old woman with no relevant medical history presents a simple congenital constriction band in the distal part of both legs, without functional impairment (Type 1 Patterson Classification). The right leg had an incomplete circumferential constriction band with minimal depth, and the left leg a circumferential constriction band of moderate depth. The left leg was treated. The procedure was performed under epidural anesthesia with intravenous sedation [32] (Figure 4).
\nPreoperative images of the left leg. (A) Lateral view, (B) frontal view, (C) medial view.
Three approaches (2 mm) that were remote to the constriction band were marked. Initially, the fibrous band was released from the deep tissues with a flat-grove blunt-tipped 2-mm Toledo cannula, 10 cm in length. Afterward, with this same cannula, multiple perpendicular cuts were made in the inner surface of the fibrous ring leaving a 1 cm gap between each cut until completing the circumference of the band.
\nLipoinjection was performed in the virtual subcutaneous space from a deep to a superficial plane with a 2-mm blunt cannula with 5-ml syringes. We injected the amount of fat needed to reverse the appearance of depression without overcorrecting (Figure 5).
\nChange in the concave surface (“hourglass sign”) for a homogeneous surface. (A, C, E) preoperative view. (B, D, F) postoperative view 18 months after the procedure (note the three approaches with some degree of hyperpigmentation).
A 27-year-old female with no significant history requested a facial profiling procedure.
\nThe patient presented adequate skin quality; however, she was not satisfied with the definition of her facial frame and neck. Today, patients come to our consultation with a lot of Internet information, and in many cases, they request specific procedures. It is always good to listen to them, and in this way, know how to properly advise our patients. After an adequate clinical evaluation, we suggested carrying out the following procedures: Bichectomy, neck liposculpture, and enhance the definition of the entire lower facial frame by volumetric lipoinjection with adipose stem cells, in addition to a slight increase in projection on the upper lip in the philtrum region.
\nFor seven years, we have developed an innovative alternative for nasal modeling. In this case, we also use fat and stem cells (in our practice, we have named this RINO-CELL®).
\nTo a large extent, we consider that the success of any procedure in facial esthetics lies in obtaining an adequate definition of the full jaw contour. In this way, it is possible to visualize the border between the face and the neck, and it is also our objective to redefine the cervicofacial angle. All these characteristics represent a clear sign of beauty and youth (Figure 6).
\n(A, C, E) preoperative view. (B, D, F) postoperative view 10 days after the procedure.
In a recent systematic analysis, Gornitsky et al. describe 2.2% complications in facial fat transfer procedures, with asymmetry being the most common. Other complications are skin irregularities, prolonged edema, hypertrophy, fat necrosis, infection, telangiectasia, and acne reactivation [33].
\nCases of emboli following autologous fat grafting to the glabella and nose have been attributed to retrograde arterial injection, facilitated by the abundant vascular supply in these regions; notably, the frontal and dorsal nasal arteries that are supplied by the ophthalmic artery [34].
\nIn our experience, we have found a reabsorption percentage of 49% of the injected volume. We have concluded that when the results are not favorable, the volume of fat calculated and injected was insufficient or to other particularities that increase reabsorption in the specific area. These situations may be resolved with secondary or re-touch procedures.
\nMost parents reported feeling happier with their children’s facial appearance. An important factor to consider is the variability of reabsorption of the injected fat. However, if necessary, the fat injection can be repeated as an isolated procedure.
\nIt is important to comment that current evidence regarding lipoinjection with adipose stem cells suggests that they can increase the permanence of the grafted fat to a certain degree; however, it is essential to explain to patients that this procedure can be repeated to obtain a better result in the medium and long term.
\nWe believe that lipoinjection alone or with adipose stem cells is an excellent alternative to improve appearance in patients suffering from a wide range of craniofacial malformations or sequelae.
\nThe search for a more youthful appearance is constant; therefore, we consider that lipoinjection as facial contouring, or in combination with other rejuvenation techniques, currently constitute an excellent therapeutic resource in facial esthetics.
\nFinally, we consider that the facial image plays a significant role in psychosocial development and integration. We believe that volumetric lipoinjection with or without adipose stem cells represents an excellent alternative to obtain greater facial esthetic harmony, which directly contributes to the self-esteem of children and adult patients.
\nWe want to thank our patients and their families for allowing us to be a part of their process and for sharing their experiences for educational purposes.
\nThe authors declare no conflict of interest.
IntechOpen Compacts provide a mid-length publishing format which bridges the gap between journal articles, book chapters and monographs, and cover content across all scientific disciplines. Compacts are the preferred publishing option for brief research reports on new topics, in-depth case studies, dissertations, or essays exploring new ideas, issues or broader topics on the research subject.
",metaTitle:"IntechOpen Compacts",metaDescription:"IntechOpen Compacts present a mid-length publishing format which bridges the gap between journal articles, book chapters, and monographs and covers content across all scientific disciplines.",metaKeywords:null,canonicalURL:"/page/compacts",contentRaw:'[{"type":"htmlEditorComponent","content":"Without sacrificing the quality of carefully edited and produced peer-reviewed content, Compacts are published as part of IntechOpen’s book collection but on a faster schedule, typically 4-6 weeks after acceptance. With an average of 132,000 visitors per week, publishing in Compacts not only guarantees high visibility but also facilitates international content sharing. As a fully Open Access publisher, the utilization of a CC BY NC 4.0 license means that other researchers will never have to pay permission fees and can adapt, use, and further build upon the material published in Compacts, eliminating any barriers to the further development of scientific research.
\\n\\nCOMPACTS-SHORT FORM MONOGRAPH
\\n\\nCOST
\\n\\n4,000 GBP Compacts Monograph - Short Form
\\n\\nThe final price will depend on the volume of the publication and includes project management, editorial and peer-review services, technical editing, language copyediting, cover design, book layout, book promotion and ISBN assignment.
\\n\\n*The price does not include Value-Added Tax (VAT). Residents of European Union countries need to add VAT based on the specific rate applicable in their country of residence. Institutions and companies registered as VAT taxable entities in their own EU member state will not pay VAT by providing us with their VAT registration number. This is made possible by the EU reverse charge method.
\\n\\nOptional Services
\\n\\nIntechOpen has collaborated with Enago, through its sister company, Ulatus – one of the world’s leading providers of book translation services. The services are designed to convey the essence of your work seamlessly to readers from across the globe in their own language. Enago’s expert translators incorporate cultural nuances in translations to make the content relevant for local audiences while retaining the original meaning and style. With a high degree of linguistic and subject expertise, Enago translators are equipped to handle all complex and multiple overlapping themes encompassed in a single book to deliver a superior quality of translation.
\\n\\nIntechOpen Authors that wish to use this service will receive a 20% discount on all translation work. For more information or a quote, please visit: https://www.enago.com/intech.
\\n\\nFUNDING
\\n\\nWe feel that financial barriers should never prevent researchers from publishing their research. Please consult our Open Access Funding page to explore funding opportunities and learn more about how you can finance your IntechOpen publication.
\\n\\nBENEFITS
\\n\\nPUBLISHING PROCESS STEPS
\\n\\nSee a complete overview and description of the steps involved in the publishing process here.
\\n\\nSEND YOUR PROPOSAL
\\n\\nIf you are interested in publishing your book with IntechOpen, please submit your book proposal by completing the Publishing Proposal Form.
\\n\\nNot sure if this is the right option for you? Please refer back to the main Publish with IntechOpen page or feel free to contact us directly at book.department@intechopen.com
\\n"}]'},components:[{type:"htmlEditorComponent",content:'Without sacrificing the quality of carefully edited and produced peer-reviewed content, Compacts are published as part of IntechOpen’s book collection but on a faster schedule, typically 4-6 weeks after acceptance. With an average of 132,000 visitors per week, publishing in Compacts not only guarantees high visibility but also facilitates international content sharing. As a fully Open Access publisher, the utilization of a CC BY NC 4.0 license means that other researchers will never have to pay permission fees and can adapt, use, and further build upon the material published in Compacts, eliminating any barriers to the further development of scientific research.
\n\nCOMPACTS-SHORT FORM MONOGRAPH
\n\nCOST
\n\n4,000 GBP Compacts Monograph - Short Form
\n\nThe final price will depend on the volume of the publication and includes project management, editorial and peer-review services, technical editing, language copyediting, cover design, book layout, book promotion and ISBN assignment.
\n\n*The price does not include Value-Added Tax (VAT). Residents of European Union countries need to add VAT based on the specific rate applicable in their country of residence. Institutions and companies registered as VAT taxable entities in their own EU member state will not pay VAT by providing us with their VAT registration number. This is made possible by the EU reverse charge method.
\n\nOptional Services
\n\nIntechOpen has collaborated with Enago, through its sister company, Ulatus – one of the world’s leading providers of book translation services. The services are designed to convey the essence of your work seamlessly to readers from across the globe in their own language. Enago’s expert translators incorporate cultural nuances in translations to make the content relevant for local audiences while retaining the original meaning and style. With a high degree of linguistic and subject expertise, Enago translators are equipped to handle all complex and multiple overlapping themes encompassed in a single book to deliver a superior quality of translation.
\n\nIntechOpen Authors that wish to use this service will receive a 20% discount on all translation work. For more information or a quote, please visit: https://www.enago.com/intech.
\n\nFUNDING
\n\nWe feel that financial barriers should never prevent researchers from publishing their research. Please consult our Open Access Funding page to explore funding opportunities and learn more about how you can finance your IntechOpen publication.
\n\nBENEFITS
\n\nPUBLISHING PROCESS STEPS
\n\nSee a complete overview and description of the steps involved in the publishing process here.
\n\nSEND YOUR PROPOSAL
\n\nIf you are interested in publishing your book with IntechOpen, please submit your book proposal by completing the Publishing Proposal Form.
\n\nNot sure if this is the right option for you? Please refer back to the main Publish with IntechOpen page or feel free to contact us directly at book.department@intechopen.com
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6675},{group:"region",caption:"Middle and South America",value:2,count:5955},{group:"region",caption:"Africa",value:3,count:2458},{group:"region",caption:"Asia",value:4,count:12718},{group:"region",caption:"Australia and Oceania",value:5,count:1017},{group:"region",caption:"Europe",value:6,count:17720}],offset:12,limit:12,total:134177},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{topicId:"13"},books:[{type:"book",id:"11369",title:"RNA Viruses",subtitle:null,isOpenForSubmission:!0,hash:"52f8a3a1486912beae40b34ac557fed3",slug:null,bookSignature:"Ph.D. Yogendra Shah",coverURL:"https://cdn.intechopen.com/books/images_new/11369.jpg",editedByType:null,editors:[{id:"278914",title:"Ph.D.",name:"Yogendra",surname:"Shah",slug:"yogendra-shah",fullName:"Yogendra Shah"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11630",title:"Life in Extreme Environments - Diversity, Adaptability and Valuable Resources of Bioactive Molecules",subtitle:null,isOpenForSubmission:!0,hash:"9c39aa5fd22296ba53d87df6d761a5fc",slug:null,bookSignature:"Dr. Afef Najjari",coverURL:"https://cdn.intechopen.com/books/images_new/11630.jpg",editedByType:null,editors:[{id:"196823",title:"Dr.",name:"Afef",surname:"Najjari",slug:"afef-najjari",fullName:"Afef Najjari"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11632",title:"Updated Research on Bacteriophages",subtitle:null,isOpenForSubmission:!0,hash:"d34dfa0d5d10511184f97ddaeef9936b",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11632.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11633",title:"Pseudomonas aeruginosa - New Perspectives and Applications",subtitle:null,isOpenForSubmission:!0,hash:"a7cd19791397a27a80526be0dc54bd8a",slug:null,bookSignature:"Associate Prof. Osama Darwesh and Dr. Ibrahim Matter",coverURL:"https://cdn.intechopen.com/books/images_new/11633.jpg",editedByType:null,editors:[{id:"298076",title:"Associate Prof.",name:"Osama",surname:"Darwesh",slug:"osama-darwesh",fullName:"Osama Darwesh"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11634",title:"Mycobacterium - Epidemiology, Prevention, Diagnostic, and Management",subtitle:null,isOpenForSubmission:!0,hash:"aa972af90c14eb4ef39b6dc71911f623",slug:null,bookSignature:"Dr. Awelani Mutshembele",coverURL:"https://cdn.intechopen.com/books/images_new/11634.jpg",editedByType:null,editors:[{id:"468847",title:"Dr.",name:"Awelani",surname:"Mutshembele",slug:"awelani-mutshembele",fullName:"Awelani Mutshembele"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11635",title:"Towards New Perspectives on Toxoplasma gondii",subtitle:null,isOpenForSubmission:!0,hash:"2d409a285bea682efb34a817b0651aba",slug:null,bookSignature:"Dr. Saeed El-Ashram, Dr. Guillermo Téllez and Dr. Firas Alali",coverURL:"https://cdn.intechopen.com/books/images_new/11635.jpg",editedByType:null,editors:[{id:"209746",title:"Dr.",name:"Saeed",surname:"El-Ashram",slug:"saeed-el-ashram",fullName:"Saeed El-Ashram"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11796",title:"Cytomegalovirus - Recent Advances",subtitle:null,isOpenForSubmission:!0,hash:"4e442adc2808f68ccc1aeac17e6ae746",slug:null,bookSignature:"Dr. Seyyed Shamsadin Athari and Dr. Entezar Mehrabi Nasab",coverURL:"https://cdn.intechopen.com/books/images_new/11796.jpg",editedByType:null,editors:[{id:"139889",title:"Dr.",name:"Seyyed Shamsadin",surname:"Athari",slug:"seyyed-shamsadin-athari",fullName:"Seyyed Shamsadin Athari"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11797",title:"Clostridium difficile",subtitle:null,isOpenForSubmission:!0,hash:"4cb066b44bb8d4a8b93a627de26e3ebf",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11797.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11798",title:"Listeria monocytogenes",subtitle:null,isOpenForSubmission:!0,hash:"678ca4185133438014939804bf8a05e6",slug:null,bookSignature:"Prof. Cristina Saraiva, Dr. Sónia Saraiva and Prof. Alexandra Esteves",coverURL:"https://cdn.intechopen.com/books/images_new/11798.jpg",editedByType:null,editors:[{id:"226197",title:"Prof.",name:"Cristina",surname:"Saraiva",slug:"cristina-saraiva",fullName:"Cristina Saraiva"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11799",title:"Salmonella - Past, Present and Future",subtitle:null,isOpenForSubmission:!0,hash:"6ddb13c31fb19c6f79d19f11ceeb860e",slug:null,bookSignature:"Ph.D. Hongsheng Huang and Dr. Sohail Naushad",coverURL:"https://cdn.intechopen.com/books/images_new/11799.jpg",editedByType:null,editors:[{id:"342722",title:"Ph.D.",name:"Hongsheng",surname:"Huang",slug:"hongsheng-huang",fullName:"Hongsheng Huang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11800",title:"Cyanobacteria - Recent Advances and New Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"645b037b086ec8c36af614326dce9804",slug:null,bookSignature:"Dr. Archana Tiwari",coverURL:"https://cdn.intechopen.com/books/images_new/11800.jpg",editedByType:null,editors:[{id:"186791",title:"Dr.",name:"Archana",surname:"Tiwari",slug:"archana-tiwari",fullName:"Archana Tiwari"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11801",title:"Roundworms - A Survey From Past to Present",subtitle:null,isOpenForSubmission:!0,hash:"5edc96349630be8bb4e67170be677d8c",slug:null,bookSignature:"Dr. Nihal Dogan",coverURL:"https://cdn.intechopen.com/books/images_new/11801.jpg",editedByType:null,editors:[{id:"169552",title:"Dr.",name:"Nihal",surname:"Dogan",slug:"nihal-dogan",fullName:"Nihal Dogan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:38},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:13},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:23},{group:"topic",caption:"Computer and Information Science",value:9,count:24},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:15},{group:"topic",caption:"Engineering",value:11,count:65},{group:"topic",caption:"Environmental Sciences",value:12,count:10},{group:"topic",caption:"Immunology and Microbiology",value:13,count:16},{group:"topic",caption:"Materials Science",value:14,count:25},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:116},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:6},{group:"topic",caption:"Neuroscience",value:18,count:4},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:9},{group:"topic",caption:"Physics",value:20,count:9},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:23},popularBooks:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4431},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1677,editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1337,editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1309,editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:847,editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",publishedDate:"June 15th 2022",numberOfDownloads:2273,editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:591,editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:515,editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:413,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",publishedDate:"June 8th 2022",numberOfDownloads:2194,editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:341,editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"11043",title:"Endometriosis",subtitle:"Recent Advances, New Perspectives and Treatments",isOpenForSubmission:!1,hash:"7baf1c70b11d41400bb9302ae9411ca4",slug:"endometriosis-recent-advances-new-perspectives-and-treatments",bookSignature:"Giovana Ap. Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/11043.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"185930",title:"Associate Prof.",name:"Giovana",middleName:null,surname:"Gonçalves",slug:"giovana-goncalves",fullName:"Giovana Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10536",title:"Campylobacter",subtitle:null,isOpenForSubmission:!1,hash:"c4b132b741dd0a2ed539b824ab63965f",slug:"campylobacter",bookSignature:"Guillermo Tellez-Isaias and Saeed El-Ashram",coverURL:"https://cdn.intechopen.com/books/images_new/10536.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"73465",title:"Dr.",name:"Guillermo",middleName:null,surname:"Téllez",slug:"guillermo-tellez",fullName:"Guillermo Téllez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",isOpenForSubmission:!1,hash:"f197f6062c1574a9a90e50a369271bcf",slug:"starch-evolution-and-recent-advances",bookSignature:"Martins Ochubiojo Emeje",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11083",title:"Hazardous Waste Management",subtitle:null,isOpenForSubmission:!1,hash:"d553bd4f6f1c4b115ca69bd19faac7dc",slug:"hazardous-waste-management",bookSignature:"Rajesh Banu Jeyakumar, Kavitha Sankarapandian and Yukesh Kannah Ravi",coverURL:"https://cdn.intechopen.com/books/images_new/11083.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"218539",title:"Dr.",name:"Rajesh Banu",middleName:null,surname:"Jeyakumar",slug:"rajesh-banu-jeyakumar",fullName:"Rajesh Banu Jeyakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10848",title:"Tribology of Machine Elements",subtitle:"Fundamentals and Applications",isOpenForSubmission:!1,hash:"3c4ca4c4692ca8d4fa749b4ae81ec1fa",slug:"tribology-of-machine-elements-fundamentals-and-applications",bookSignature:"Giuseppe Pintaude, Tiago Cousseau and Anna Rudawska",coverURL:"https://cdn.intechopen.com/books/images_new/10848.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"18347",title:"Prof.",name:"Giuseppe",middleName:null,surname:"Pintaude",slug:"giuseppe-pintaude",fullName:"Giuseppe Pintaude"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10856",title:"Crude Oil",subtitle:"New Technologies and Recent Approaches",isOpenForSubmission:!1,hash:"8d0a7ca35b3de95b295dc4eab39a087e",slug:"crude-oil-new-technologies-and-recent-approaches",bookSignature:"Manar Elsayed Abdel-Raouf and Mohamed Hasan El-Keshawy",coverURL:"https://cdn.intechopen.com/books/images_new/10856.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"102626",title:"Prof.",name:"Manar",middleName:null,surname:"Elsayed Abdel-Raouf",slug:"manar-elsayed-abdel-raouf",fullName:"Manar Elsayed Abdel-Raouf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9625",title:"Spinocerebellar Ataxia",subtitle:"Concepts, Particularities and Generalities",isOpenForSubmission:!1,hash:"365a7025fd46eb45de2549bdd9d50b98",slug:"spinocerebellar-ataxia-concepts-particularities-and-generalities",bookSignature:"Patricia Bozzetto Ambrosi",coverURL:"https://cdn.intechopen.com/books/images_new/9625.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"221787",title:"Dr.",name:"Patricia",middleName:null,surname:"Bozzetto Ambrosi",slug:"patricia-bozzetto-ambrosi",fullName:"Patricia Bozzetto Ambrosi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10905",title:"Plant Defense Mechanisms",subtitle:null,isOpenForSubmission:!1,hash:"84ad5b27dde5f01dc76087d0fd6fa834",slug:"plant-defense-mechanisms",bookSignature:"Josphert Ngui Kimatu",coverURL:"https://cdn.intechopen.com/books/images_new/10905.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"224171",title:"Prof.",name:"Josphert N.",middleName:null,surname:"Kimatu",slug:"josphert-n.-kimatu",fullName:"Josphert N. Kimatu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10686",title:"Natural Gas",subtitle:"New Perspectives and Future Developments",isOpenForSubmission:!1,hash:"581763788a6a59e653a9d1d9b5a42d79",slug:"natural-gas-new-perspectives-and-future-developments",bookSignature:"Maryam Takht Ravanchi",coverURL:"https://cdn.intechopen.com/books/images_new/10686.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"2416",title:"Dr.",name:"Maryam",middleName:null,surname:"Takht Ravanchi",slug:"maryam-takht-ravanchi",fullName:"Maryam Takht Ravanchi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10988",title:"Railway Transport Planning and Manageme",subtitle:null,isOpenForSubmission:!1,hash:"5cb54cc53caedad9ec78372563c82e2c",slug:"railway-transport-planning-and-management",bookSignature:"Stefano de Luca, Roberta Di Pace and Chiara Fiori",coverURL:"https://cdn.intechopen.com/books/images_new/10988.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"271061",title:"Prof.",name:"Stefano",middleName:null,surname:"de Luca",slug:"stefano-de-luca",fullName:"Stefano de Luca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"720",title:"Fuzzy Control",slug:"fuzzy-control",parent:{id:"115",title:"Control Engineering",slug:"engineering-control-engineering"},numberOfBooks:1,numberOfSeries:0,numberOfAuthorsAndEditors:17,numberOfWosCitations:9,numberOfCrossrefCitations:6,numberOfDimensionsCitations:9,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"720",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"4521",title:"Fuzzy Logic",subtitle:"Tool for Getting Accurate Solutions",isOpenForSubmission:!1,hash:"37b90572d58c2c01bd61c23e908649e2",slug:"fuzzy-logic-tool-for-getting-accurate-solutions",bookSignature:"Elmer P. Dadios",coverURL:"https://cdn.intechopen.com/books/images_new/4521.jpg",editedByType:"Edited by",editors:[{id:"111683",title:"Prof.",name:"Elmer P.",middleName:"P.",surname:"Dadios",slug:"elmer-p.-dadios",fullName:"Elmer P. Dadios"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:1,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"48152",doi:"10.5772/59438",title:"Applying Fuzzy Logic to Understanding Driving Modes in Real Road Environments",slug:"applying-fuzzy-logic-to-understanding-driving-modes-in-real-road-environments",totalDownloads:1947,totalCrossrefCites:3,totalDimensionsCites:6,abstract:null,book:{id:"4521",slug:"fuzzy-logic-tool-for-getting-accurate-solutions",title:"Fuzzy Logic",fullTitle:"Fuzzy Logic - Tool for Getting Accurate Solutions"},signatures:"Toshihisa Sato and Motoyuki Akamatsu",authors:[{id:"107166",title:"Dr.",name:"Toshihisa",middleName:null,surname:"Sato",slug:"toshihisa-sato",fullName:"Toshihisa Sato"},{id:"113401",title:"Dr.",name:"Motoyuki",middleName:null,surname:"Akamatsu",slug:"motoyuki-akamatsu",fullName:"Motoyuki Akamatsu"}]},{id:"48179",doi:"10.5772/59923",title:"Application of Fuzzy Logic Control for Grid-Connected Wind Energy Conversion System",slug:"application-of-fuzzy-logic-control-for-grid-connected-wind-energy-conversion-system",totalDownloads:2177,totalCrossrefCites:2,totalDimensionsCites:2,abstract:null,book:{id:"4521",slug:"fuzzy-logic-tool-for-getting-accurate-solutions",title:"Fuzzy Logic",fullTitle:"Fuzzy Logic - Tool for Getting Accurate Solutions"},signatures:"Jianzhong Zhang and Shuai Xu",authors:[{id:"171632",title:"Prof.",name:"Jianzhong",middleName:null,surname:"Zhang",slug:"jianzhong-zhang",fullName:"Jianzhong Zhang"},{id:"172055",title:"Mr.",name:"Shuai",middleName:null,surname:"Xu",slug:"shuai-xu",fullName:"Shuai Xu"}]},{id:"47891",doi:"10.5772/59611",title:"Fuzzy Cognitive Maps for Identifying Fault Activation Patterns in Automation Systems",slug:"fuzzy-cognitive-maps-for-identifying-fault-activation-patterns-in-automation-systems",totalDownloads:1528,totalCrossrefCites:1,totalDimensionsCites:1,abstract:null,book:{id:"4521",slug:"fuzzy-logic-tool-for-getting-accurate-solutions",title:"Fuzzy Logic",fullTitle:"Fuzzy Logic - Tool for Getting Accurate Solutions"},signatures:"Salman Mohagheghi",authors:[{id:"171506",title:"Dr.",name:"Salman",middleName:null,surname:"Mohagheghi",slug:"salman-mohagheghi",fullName:"Salman Mohagheghi"}]},{id:"47928",doi:"10.5772/59814",title:"Modelling and Implementation of a Series DC Motor Drive System",slug:"modelling-and-implementation-of-a-series-dc-motor-drive-system",totalDownloads:1689,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"4521",slug:"fuzzy-logic-tool-for-getting-accurate-solutions",title:"Fuzzy Logic",fullTitle:"Fuzzy Logic - Tool for Getting Accurate Solutions"},signatures:"Angelo José Junqueira Rezek, Carlos Alberto Murari Pinheiro, Tony\nYoussif Teixeira Darido, Valberto Ferreira da Silva, Otávio Henrique\nSalvi Vicentini, Wanderson de Oliveira Assis and Rafael Di Lorenzo\nCorrêa",authors:[{id:"114149",title:"Dr.",name:"Angelo",middleName:null,surname:"Rezek",slug:"angelo-rezek",fullName:"Angelo Rezek"},{id:"114169",title:"Prof.",name:"Carlos",middleName:null,surname:"A. M. Pinheiro",slug:"carlos-a.-m.-pinheiro",fullName:"Carlos A. M. Pinheiro"},{id:"171674",title:"MSc.",name:"Tony",middleName:null,surname:"Darido",slug:"tony-darido",fullName:"Tony Darido"},{id:"171675",title:"Dr.",name:"Valberto",middleName:null,surname:"Silva",slug:"valberto-silva",fullName:"Valberto Silva"},{id:"171676",title:"Dr.",name:"Wanderson",middleName:"De Oliveira",surname:"Assis",slug:"wanderson-assis",fullName:"Wanderson Assis"},{id:"171677",title:"BSc.",name:"Otavio",middleName:null,surname:"Vicentini",slug:"otavio-vicentini",fullName:"Otavio Vicentini"},{id:"171678",title:"MSc.",name:"Rafael",middleName:null,surname:"Correa",slug:"rafael-correa",fullName:"Rafael Correa"}]},{id:"48046",doi:"10.5772/59810",title:"Self-Tuning Fuzzy PI Controller (STFPIC)",slug:"self-tuning-fuzzy-pi-controller-stfpic-",totalDownloads:1755,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"4521",slug:"fuzzy-logic-tool-for-getting-accurate-solutions",title:"Fuzzy Logic",fullTitle:"Fuzzy Logic - Tool for Getting Accurate Solutions"},signatures:"Salman Hameed",authors:[{id:"171779",title:"Associate Prof.",name:"Salman",middleName:null,surname:"Hameed",slug:"salman-hameed",fullName:"Salman Hameed"}]}],mostDownloadedChaptersLast30Days:[{id:"48179",title:"Application of Fuzzy Logic Control for Grid-Connected Wind Energy Conversion System",slug:"application-of-fuzzy-logic-control-for-grid-connected-wind-energy-conversion-system",totalDownloads:2177,totalCrossrefCites:2,totalDimensionsCites:2,abstract:null,book:{id:"4521",slug:"fuzzy-logic-tool-for-getting-accurate-solutions",title:"Fuzzy Logic",fullTitle:"Fuzzy Logic - Tool for Getting Accurate Solutions"},signatures:"Jianzhong Zhang and Shuai Xu",authors:[{id:"171632",title:"Prof.",name:"Jianzhong",middleName:null,surname:"Zhang",slug:"jianzhong-zhang",fullName:"Jianzhong Zhang"},{id:"172055",title:"Mr.",name:"Shuai",middleName:null,surname:"Xu",slug:"shuai-xu",fullName:"Shuai Xu"}]},{id:"48046",title:"Self-Tuning Fuzzy PI Controller (STFPIC)",slug:"self-tuning-fuzzy-pi-controller-stfpic-",totalDownloads:1755,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"4521",slug:"fuzzy-logic-tool-for-getting-accurate-solutions",title:"Fuzzy Logic",fullTitle:"Fuzzy Logic - Tool for Getting Accurate Solutions"},signatures:"Salman Hameed",authors:[{id:"171779",title:"Associate Prof.",name:"Salman",middleName:null,surname:"Hameed",slug:"salman-hameed",fullName:"Salman Hameed"}]},{id:"48432",title:"A Simple Fuzzy System Applied to Predict Default Rate",slug:"a-simple-fuzzy-system-applied-to-predict-default-rate",totalDownloads:1720,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"4521",slug:"fuzzy-logic-tool-for-getting-accurate-solutions",title:"Fuzzy Logic",fullTitle:"Fuzzy Logic - Tool for Getting Accurate Solutions"},signatures:"Fábio M. Soares, Olavo S. Rocha Neto and Hevertton H. K. Barbosa",authors:[{id:"104491",title:"MSc.",name:"Fabio",middleName:null,surname:"Soares",slug:"fabio-soares",fullName:"Fabio Soares"},{id:"171947",title:"BSc.",name:"Olavo",middleName:null,surname:"Rocha",slug:"olavo-rocha",fullName:"Olavo Rocha"},{id:"171948",title:"BSc.",name:"Hevertton",middleName:null,surname:"Barbosa",slug:"hevertton-barbosa",fullName:"Hevertton Barbosa"}]},{id:"47928",title:"Modelling and Implementation of a Series DC Motor Drive System",slug:"modelling-and-implementation-of-a-series-dc-motor-drive-system",totalDownloads:1689,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"4521",slug:"fuzzy-logic-tool-for-getting-accurate-solutions",title:"Fuzzy Logic",fullTitle:"Fuzzy Logic - Tool for Getting Accurate Solutions"},signatures:"Angelo José Junqueira Rezek, Carlos Alberto Murari Pinheiro, Tony\nYoussif Teixeira Darido, Valberto Ferreira da Silva, Otávio Henrique\nSalvi Vicentini, Wanderson de Oliveira Assis and Rafael Di Lorenzo\nCorrêa",authors:[{id:"114149",title:"Dr.",name:"Angelo",middleName:null,surname:"Rezek",slug:"angelo-rezek",fullName:"Angelo Rezek"},{id:"114169",title:"Prof.",name:"Carlos",middleName:null,surname:"A. M. Pinheiro",slug:"carlos-a.-m.-pinheiro",fullName:"Carlos A. M. Pinheiro"},{id:"171674",title:"MSc.",name:"Tony",middleName:null,surname:"Darido",slug:"tony-darido",fullName:"Tony Darido"},{id:"171675",title:"Dr.",name:"Valberto",middleName:null,surname:"Silva",slug:"valberto-silva",fullName:"Valberto Silva"},{id:"171676",title:"Dr.",name:"Wanderson",middleName:"De Oliveira",surname:"Assis",slug:"wanderson-assis",fullName:"Wanderson Assis"},{id:"171677",title:"BSc.",name:"Otavio",middleName:null,surname:"Vicentini",slug:"otavio-vicentini",fullName:"Otavio Vicentini"},{id:"171678",title:"MSc.",name:"Rafael",middleName:null,surname:"Correa",slug:"rafael-correa",fullName:"Rafael Correa"}]},{id:"47891",title:"Fuzzy Cognitive Maps for Identifying Fault Activation Patterns in Automation Systems",slug:"fuzzy-cognitive-maps-for-identifying-fault-activation-patterns-in-automation-systems",totalDownloads:1528,totalCrossrefCites:1,totalDimensionsCites:1,abstract:null,book:{id:"4521",slug:"fuzzy-logic-tool-for-getting-accurate-solutions",title:"Fuzzy Logic",fullTitle:"Fuzzy Logic - Tool for Getting Accurate Solutions"},signatures:"Salman Mohagheghi",authors:[{id:"171506",title:"Dr.",name:"Salman",middleName:null,surname:"Mohagheghi",slug:"salman-mohagheghi",fullName:"Salman Mohagheghi"}]}],onlineFirstChaptersFilter:{topicId:"720",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:15,paginationItems:[{id:"82427",title:"Our Globalization Era among Success, Obstacles and Doubts",doi:"10.5772/intechopen.105545",signatures:"Arnaldo Canziani, Annalisa Baldissera and Ahmad Kahwaji",slug:"our-globalization-era-among-success-obstacles-and-doubts",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}},{id:"82248",title:"Sustainability and Excellence: Pillars for Business Survival",doi:"10.5772/intechopen.105420",signatures:"Irina Severin, Maria Cristina Dijmarescu and Mihai Caramihai",slug:"sustainability-and-excellence-pillars-for-business-survival",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}},{id:"82124",title:"Assessment of Diversity, Growth Characteristics and Aboveground Biomass of Tree Species in Selected Urban Green Areas of Osogbo, Osun State",doi:"10.5772/intechopen.104982",signatures:"Omolara Aremu, Olusola O. Adetoro and Olusegun Awotoye",slug:"assessment-of-diversity-growth-characteristics-and-aboveground-biomass-of-tree-species-in-selected-u",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",subseries:{id:"94",title:"Climate Change and Environmental Sustainability"}}},{id:"81975",title:"Self-Sustained Communities: Food Security in Times of Crisis",doi:"10.5772/intechopen.104425",signatures:"Kriengsak Chareonwongsak",slug:"self-sustained-communities-food-security-in-times-of-crisis",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}}]},overviewPagePublishedBooks:{paginationCount:0,paginationItems:[]},openForSubmissionBooks:{paginationCount:6,paginationItems:[{id:"11669",title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",hash:"9117bd12dc904ced43404e3383b6591a",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 3rd 2022",isOpenForSubmission:!0,editors:[{id:"415310",title:"Assistant Prof.",name:"Erik",surname:"Froyen",slug:"erik-froyen",fullName:"Erik Froyen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11672",title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",hash:"c00855833476a514d37abf7c846e16e9",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 6th 2022",isOpenForSubmission:!0,editors:[{id:"14794",title:"Prof.",name:"Murat",surname:"Şentürk",slug:"murat-senturk",fullName:"Murat Şentürk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11674",title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",hash:"5d7d49bd80f53dad3761f78de4a862c6",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 6th 2022",isOpenForSubmission:!0,editors:[{id:"238047",title:"Dr.",name:"Gaia",surname:"Favero",slug:"gaia-favero",fullName:"Gaia Favero"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11670",title:"Chitin-Chitosan - Isolation, Properties, and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11670.jpg",hash:"69f009be08998711eecfb200adc7deca",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 26th 2022",isOpenForSubmission:!0,editors:[{id:"176093",title:"Dr.",name:"Brajesh",surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11673",title:"Stem Cell Research",coverURL:"https://cdn.intechopen.com/books/images_new/11673.jpg",hash:"13092df328080c762dd9157be18ca38c",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 13th 2022",isOpenForSubmission:!0,editors:[{id:"203598",title:"Ph.D.",name:"Diana",surname:"Kitala",slug:"diana-kitala",fullName:"Diana Kitala"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"12215",title:"Cell Death and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/12215.jpg",hash:"dfd456a29478fccf4ebd3294137eb1e3",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 29th 2022",isOpenForSubmission:!0,editors:[{id:"59529",title:"Dr.",name:"Ke",surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:54,paginationItems:[{id:"81595",title:"Prosthetic Concepts in Dental Implantology",doi:"10.5772/intechopen.104725",signatures:"Ivica Pelivan",slug:"prosthetic-concepts-in-dental-implantology",totalDownloads:25,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"80963",title:"Pain Perception in Patients Treated with Ligating/Self-Ligating Brackets versus Patients Treated with Aligners",doi:"10.5772/intechopen.102796",signatures:"Farid Bourzgui, Rania Fastani, Salwa Khairat, Samir Diouny, Mohamed El Had, Zineb Serhier and Mohamed Bennani Othmani",slug:"pain-perception-in-patients-treated-with-ligating-self-ligating-brackets-versus-patients-treated-wit",totalDownloads:22,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Trends in Orthodontics",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"80964",title:"Upper Airway Expansion in Disabled Children",doi:"10.5772/intechopen.102830",signatures:"David Andrade, Joana Andrade, Maria-João Palha, Cristina Areias, Paula Macedo, Ana Norton, Miguel Palha, Lurdes Morais, Dóris Rocha Ruiz and Sônia Groisman",slug:"upper-airway-expansion-in-disabled-children",totalDownloads:35,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80839",title:"Herbs and Oral Health",doi:"10.5772/intechopen.103715",signatures:"Zuhair S. Natto",slug:"herbs-and-oral-health",totalDownloads:57,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80500",title:"Novel Dental Implants with Herbal Composites: A Review",doi:"10.5772/intechopen.101489",signatures:"Gopathy Sridevi and Seshadri Srividya",slug:"novel-dental-implants-with-herbal-composites-a-review",totalDownloads:49,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"78320",title:"Implant-Retained Maxillary and Mandibular Overdentures - A Solution for Completely Edentulous Patients",doi:"10.5772/intechopen.99575",signatures:"Dubravka Knezović Zlatarić, Robert Ćelić and Hrvoje Pezo",slug:"implant-retained-maxillary-and-mandibular-overdentures-a-solution-for-completely-edentulous-patients",totalDownloads:66,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"80441",title:"Periodontitis and Heart Disease: Current Perspectives on the Associative Relationships and Preventive Impact",doi:"10.5772/intechopen.102669",signatures:"Alexandra Roman, Andrada Soancă, Bogdan Caloian, Alexandru Bucur, Gabriela Valentina Caracostea, Andreia Paraschiva Preda, Dora Maria Popescu, Iulia Cristina Micu, Petra Șurlin, Andreea Ciurea, Diana Oneț, Mircea Viorel Ciurea, Dragoș Alexandru Țermure and Marius Negucioiu",slug:"periodontitis-and-heart-disease-current-perspectives-on-the-associative-relationships-and-preventive",totalDownloads:54,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79498",title:"Oral Aspects and Dental Management of Special Needs Patient",doi:"10.5772/intechopen.101067",signatures:"Pinar Kiymet Karataban",slug:"oral-aspects-and-dental-management-of-special-needs-patient",totalDownloads:84,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Pinar",surname:"Karataban"}],book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79699",title:"Metabolomics Distinction of Cigarette Smokers from Non-Smokers Using Non-Stationary Benchtop Nuclear Magnetic Resonance (NMR) Analysis of Human Saliva",doi:"10.5772/intechopen.101414",signatures:"Benita C. Percival, Angela Wann, Sophie Taylor, Mark Edgar, Miles Gibson and Martin Grootveld",slug:"metabolomics-distinction-of-cigarette-smokers-from-non-smokers-using-non-stationary-benchtop-nuclear",totalDownloads:54,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80295",title:"Preventive Methods and Treatments of White Spot Lesions in Orthodontics",doi:"10.5772/intechopen.102064",signatures:"Elif Nadide Akay",slug:"preventive-methods-and-treatments-of-white-spot-lesions-in-orthodontics",totalDownloads:82,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}}]},subseriesFiltersForOFChapters:[{caption:"Oral Health",value:1,count:20,group:"subseries"},{caption:"Prosthodontics and Implant Dentistry",value:2,count:34,group:"subseries"}],publishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"7102",title:"Pneumonia",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7102.jpg",slug:"pneumonia",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Nima Rezaei",hash:"9fd70142814192dcec58a176749f1b60",volumeInSeries:13,fullTitle:"Pneumonia",editors:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9615",title:"Chikungunya Virus",subtitle:"A Growing Global Public Health Threat",coverURL:"https://cdn.intechopen.com/books/images_new/9615.jpg",slug:"chikungunya-virus-a-growing-global-public-health-threat",publishedDate:"February 9th 2022",editedByType:"Edited by",bookSignature:"Jean Engohang-Ndong",hash:"c960d94a63867dd12a8ab15176a3ff06",volumeInSeries:12,fullTitle:"Chikungunya Virus - A Growing Global Public Health Threat",editors:[{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",institutionString:"Kent State University",institution:{name:"Kent State University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9619",title:"Epstein-Barr Virus",subtitle:"New Trends",coverURL:"https://cdn.intechopen.com/books/images_new/9619.jpg",slug:"epstein-barr-virus-new-trends",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Emmanuel Drouet",hash:"a2128c53becb6064589570cbe8d976f8",volumeInSeries:11,fullTitle:"Epstein-Barr Virus - New Trends",editors:[{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",institutionString:null,institution:{name:"Grenoble Alpes University",institutionURL:null,country:{name:"France"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9525",title:"Insights Into Drug Resistance in Staphylococcus aureus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9525.jpg",slug:"insights-into-drug-resistance-in-staphylococcus-aureus",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Amjad Aqib",hash:"98bb6c1ddb067da67185c272f81c0a27",volumeInSeries:10,fullTitle:"Insights Into Drug Resistance in Staphylococcus aureus",editors:[{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9614",title:"Advances in Candida albicans",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9614.jpg",slug:"advances-in-candida-albicans",publishedDate:"November 17th 2021",editedByType:"Edited by",bookSignature:"Xinhui Wang",hash:"31d6882518ca749b12715266eed0a018",volumeInSeries:9,fullTitle:"Advances in Candida albicans",editors:[{id:"296531",title:"Dr.",name:"Xinhui",middleName:null,surname:"Wang",slug:"xinhui-wang",fullName:"Xinhui Wang",profilePictureURL:"https://mts.intechopen.com/storage/users/296531/images/system/296531.jpg",institutionString:"Qinghai Normal University",institution:{name:"University of Luxembourg",institutionURL:null,country:{name:"Luxembourg"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9528",title:"Current Topics and Emerging Issues in Malaria Elimination",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9528.jpg",slug:"current-topics-and-emerging-issues-in-malaria-elimination",publishedDate:"July 21st 2021",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"7f178329cc42e691efe226b32f14e2ea",volumeInSeries:8,fullTitle:"Current Topics and Emerging Issues in Malaria Elimination",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9613",title:"Dengue Fever in a One Health Perspective",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9613.jpg",slug:"dengue-fever-in-a-one-health-perspective",publishedDate:"October 28th 2020",editedByType:"Edited by",bookSignature:"Márcia Aparecida Sperança",hash:"77ecce8195c11092230b4156df6d83ff",volumeInSeries:7,fullTitle:"Dengue Fever in a One Health Perspective",editors:[{id:"176579",title:"Dr.",name:"Márcia Aparecida",middleName:null,surname:"Sperança",slug:"marcia-aparecida-speranca",fullName:"Márcia Aparecida Sperança",profilePictureURL:"https://mts.intechopen.com/storage/users/176579/images/system/176579.jpg",institutionString:null,institution:{name:"Universidade Federal do ABC",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7981",title:"Overview on Echinococcosis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7981.jpg",slug:"overview-on-echinococcosis",publishedDate:"April 22nd 2020",editedByType:"Edited by",bookSignature:"Fethi Derbel and Meriem Braiki",hash:"24dee9209f3fd6b7cd28f042da0076f0",volumeInSeries:6,fullTitle:"Overview on Echinococcosis",editors:[{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",institutionString:"Clinique les Oliviers",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7887",title:"Hepatitis B and C",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7887.jpg",slug:"hepatitis-b-and-c",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Luis Rodrigo",hash:"8dd6dab483cf505d83caddaeaf497f2c",volumeInSeries:5,fullTitle:"Hepatitis B and C",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo",profilePictureURL:"https://mts.intechopen.com/storage/users/73208/images/system/73208.jpg",institutionString:"University of Oviedo",institution:{name:"University of Oviedo",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:229,paginationItems:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",biography:"Dr. Aneesa Moolla has extensive experience in the diverse fields of health care having previously worked in dental private practice, at the Red Cross Flying Doctors association, and in healthcare corporate settings. She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",country:{name:"Spain"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. Her knowledge of English is at an advanced level.",institutionString:null,institution:null},{id:"332914",title:"Dr.",name:"Muhammad Saad",middleName:null,surname:"Shaikh",slug:"muhammad-saad-shaikh",fullName:"Muhammad Saad Shaikh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jinnah Sindh Medical University",country:{name:"Pakistan"}}},{id:"315775",title:"Dr.",name:"Feng",middleName:null,surname:"Luo",slug:"feng-luo",fullName:"Feng Luo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sichuan University",country:{name:"China"}}},{id:"423519",title:"Dr.",name:"Sizakele",middleName:null,surname:"Ngwenya",slug:"sizakele-ngwenya",fullName:"Sizakele Ngwenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419270",title:"Dr.",name:"Ann",middleName:null,surname:"Chianchitlert",slug:"ann-chianchitlert",fullName:"Ann Chianchitlert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419271",title:"Dr.",name:"Diane",middleName:null,surname:"Selvido",slug:"diane-selvido",fullName:"Diane Selvido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419272",title:"Dr.",name:"Irin",middleName:null,surname:"Sirisoontorn",slug:"irin-sirisoontorn",fullName:"Irin Sirisoontorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"355660",title:"Dr.",name:"Anitha",middleName:null,surname:"Mani",slug:"anitha-mani",fullName:"Anitha Mani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"355612",title:"Dr.",name:"Janani",middleName:null,surname:"Karthikeyan",slug:"janani-karthikeyan",fullName:"Janani Karthikeyan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"334400",title:"Dr.",name:"Suvetha",middleName:null,surname:"Siva",slug:"suvetha-siva",fullName:"Suvetha Siva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}}]}},subseries:{item:{id:"9",type:"subseries",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11405,editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",biography:"Dr. Luis Villarreal is a research professor from the Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana, Baja California, México. Dr. Villarreal is the editor in chief and founder of the Revista de Ciencias Tecnológicas (RECIT) (https://recit.uabc.mx/) and is a member of several editorial and reviewer boards for numerous international journals. He has published more than thirty international papers and reviewed more than ninety-two manuscripts. His research interests include biomaterials, nanomaterials, bioengineering, biosensors, drug delivery systems, and tissue engineering.",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",slug:"cecilia-cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",slug:"gil-goncalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",slug:"johann-f.-osma",fullName:"Johann F. Osma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDv7QAG/Profile_Picture_1626602531691",institutionString:null,institution:{name:"Universidad de Los Andes",institutionURL:null,country:{name:"Colombia"}}},{id:"69697",title:"Dr.",name:"Mani T.",middleName:null,surname:"Valarmathi",slug:"mani-t.-valarmathi",fullName:"Mani T. Valarmathi",profilePictureURL:"https://mts.intechopen.com/storage/users/69697/images/system/69697.jpg",institutionString:"Religen Inc. | A Life Science Company, United States of America",institution:null},{id:"205081",title:"Dr.",name:"Marco",middleName:"Vinícius",surname:"Chaud",slug:"marco-chaud",fullName:"Marco Chaud",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDGeQAO/Profile_Picture_1622624307737",institutionString:null,institution:{name:"Universidade de Sorocaba",institutionURL:null,country:{name:"Brazil"}}}]},onlineFirstChapters:{paginationCount:2,paginationItems:[{id:"82392",title:"Nanomaterials as Novel Biomarkers for Cancer Nanotheranostics: State of the Art",doi:"10.5772/intechopen.105700",signatures:"Hao Yu, Zhihai Han, Cunrong Chen and Leisheng Zhang",slug:"nanomaterials-as-novel-biomarkers-for-cancer-nanotheranostics-state-of-the-art",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11405.jpg",subseries:{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering"}}},{id:"81778",title:"Influence of Mechanical Properties of Biomaterials on the Reconstruction of Biomedical Parts via Additive Manufacturing Techniques: An Overview",doi:"10.5772/intechopen.104465",signatures:"Babatunde Olamide Omiyale, Akeem Abiodun Rasheed, Robinson Omoboyode Akinnusi and Temitope Olumide Olugbade",slug:"influence-of-mechanical-properties-of-biomaterials-on-the-reconstruction-of-biomedical-parts-via-add",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11405.jpg",subseries:{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering"}}}]},publishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"7437",title:"Nanomedicines",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7437.jpg",slug:"nanomedicines",publishedDate:"February 13th 2019",editedByType:"Edited by",bookSignature:"Muhammad Akhyar Farrukh",hash:"0e1f5f6258f074c533976c4f4d248568",volumeInSeries:5,fullTitle:"Nanomedicines",editors:[{id:"63182",title:"Dr.",name:"Muhammad Akhyar",middleName:null,surname:"Farrukh",slug:"muhammad-akhyar-farrukh",fullName:"Muhammad Akhyar Farrukh",profilePictureURL:"https://mts.intechopen.com/storage/users/63182/images/system/63182.png",institutionString:"Forman Christian College",institution:{name:"Forman Christian College",institutionURL:null,country:{name:"Pakistan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[{id:"14",title:"Cell and Molecular Biology",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression"},{id:"15",title:"Chemical Biology",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors"},{id:"17",title:"Metabolism",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation"},{id:"18",title:"Proteomics",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:{title:"Biochemistry",id:"11"},selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/260451",hash:"",query:{},params:{id:"260451"},fullPath:"/profiles/260451",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()