Categories of substitutable applications, selected examples and MedMetrics [12].
\r\n\tThere will be a chapter on secondary causes of sexual dysfunction disorders related to diabetes, cardiovascular disease, and obesity. A chapter on remedial measures to enhance sexual activity and maintain human relationships will be discussed. As there is a growing number of cancer survivors a chapter on cancer-related sexual dysfunction will be welcomed for including it.
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From using fingerprint with ink on paper for a residence card in ancient China to using fingerprint on the digital optic scanner, from face recognition at door entry system to ECG identification for patients, the biometrics technologies have been re-defined in the last decade to fit the ever-increasing needs in advanced biometrics technologies. The latest developments were derived from the enormous boosting of personal mobile devices, the improved affordability of fingerprint sensors and CCTV cameras, the fast 4G and 5G communication network, and the increasingly successful cases of using biometrics in public and private sectors.
Generally speaking, a typical biometrics identification system will firstly record the physical or behavioural characteristics as the ground truth of personal identity, sometimes combine with personal information, e.g., name, gender, date of birth, address, and identification number if applicable. Secondly, a biometrics system will transform single or multiple biometrics and personal information into one encrypted code representing an individual. There is an algorithm to decide the similarity matrix among different codes. When a user attempts to get authorised by using a biometrics identification system, a decision threshold will be applied to decide whether to grant or deny the authorisation.
There are multiple agents within the organisational network to enable the processes of biometrics authorisation. For example, as shown in Figure 1, the Image Acquiring Agent is to collect biometrics information (in this example it is an iris image), the Iris Image Processing Agent is to encoding the biometrics information into a code using an embedded algorithm, and the Iris Image Identification Agent is to compare the attempted code with the code that stored in its database for matching. There are two types of matching in this case. If the biometrics system has confirmed personal information, it is a one-to-one matching. If the biometrics system does not know the personal identification information, it becomes a one-to-many (sometimes one-to-millions of people) identification.
Distributed agents’ organisation network in a typical biometrics system [
Most mobile and ubiquitous applications, such as mobile face recognition, hospital smartcard-fingerprint system, and hand-writing recognitions, use one-to-one identification. The reason behind it is simple: keep false positives low while having a high specificity rate in the biometrics identification. When biometrics is built on the one-to-many identification, which is very common in public sectors (e.g., when a police officer needs to match identification for suspects), the matching algorithm and decision threshold become utterly important and need to be customised based on the purpose. A low specificity rate in the biometrics system will lead to a waste of public resources, unfair and biased judgement of individuals.
In this chapter, the author firstly introduces an emerging area of biometrics, namely MedMetrics. The MedMetircs combines medical and biological biometrics with the ultimate aim of identifying patients and their health conditions, drugs, and medical procedures using biometrics codes. To ensure patient data privacy, MedMetrics needs to answer three questions: authentic user, real user, and when to take the action of authorisation. MedMetrics’s code is accessible and editable on current events, but all previous information will remain un-editable encryption. It can be used as a fixed baseline blockchain or a time-series blockchain that records temporal codes.
Secondly, this chapter provides insights into MedMetrics in medical science and health care. The author will discuss how traditional biometrics technologies apply to the medical and medical science field, then explain how MedMetrics can revolutionary change the user demographic, shift safety restrictions, define new user applications, and encourage ethical AI regulations in medical science and health care. The novelty of MedMetrics in the areas it applies to, such as the ‘MedMetrics Patient Passport’ and the ‘MedMetrics Drug Passport’. Because the MedMetrics codes are formed based on multiple international standard codes, the introduction of MedMetrics will help ethical and regulatory governance in developing an evaluation of medical biometrics that is trustful and repeatable.
In the last two decades, biometrics using fingerprints has been accepted and used widely as an identification measure for clinicians in hospital settings. Hospital and healthcare staff can use a smartcard with a user name and password (as a personal signature) and fingerprints for patient data access, test assignment, and drug subscriptions. In the recent 5 years, one encouraging move is that patients started to accept using face recognition on mobile phones to gain healthcare applications. Encrypted face patterns became an acceptable biometric password and inspired several applications. For example, UK residents can now complete the onboarding process for their National Health Service (NHS) login using face recognition via Apple Face ID iProov Genuine Presence Assurance [2]. After the secure facial verification, residents can access essential services online, such as appointments, personal health records, and ordering repeat prescriptions. The Programme Head for NHS login suggested that “More automated tools like this will help us to improve the experience of our users, increase demand capacity and ensure nobody is waiting too long to complete identity verification checks to gain access to their digital healthcare services” [3].
Another application that is emerging is using physiological signs as biometrics. Studies show that electrocardiogram (ECG) signals can be used as a biometrics measure [4, 5, 6]. Thanks to the highly individualised nature of the ECG, they are ubiquitous and difficult to counterfeit [7]. However, one of the main challenges in ECG-based biometric development is the lack of large ECG databases.
In this chapter, we propose two novel methods in MedMetrics can play revolution roles in the digital health
The first novel method is the ‘
The basic patient electronic health record (EHR) includes patient name, national identification, ethical group, date of birth, address, etc. This information is personal information biometrics that is often used for patient check-in at hospitals. The time-series health condition will be recorded in the International Classification of Disease (ICD) code and split by hashing space in between events or clinical visits. The medical device will be recorded under the ISO 14155: Clinical investigation of medical devices for human subjects – Good clinical [8].
To evaluate performance in healthcare with MedMetrics, the Healthcare Effectiveness Data and Information Set (HEDIS) can be used. Over 200 million people worldwide enrolled in plans that report HEDIS results. The HEDIS includes more than 90 measures across 6 domains of care, namely: effectiveness of care, access and availability of care, the experience of care, utilisation and risk-adjusted utilisation, health plan descriptive information, and measures reported using electronic clinical data systems [9].
The second method that MedMetrics can help make a revolution in the digital healthcare
This MedMetrics Drug Passport is the ultimate documentation that enables many applications that require privacy, transparency, accuracy, and uniqueness. MedMetrics can help to save people’s life by providing alerts in drug interactions. There are several types of drug interactions, the main three types are drug-drug/herbal products, drug-disease, and drug-food/alcohol. Software can help clinicians to detect drug interactions, but many programs have not been updated with the evolving knowledge of these interactions, and do not take into consideration important factors such as patients of different age groups, nutritious levels or ethical groups [10, 11].
The following are how MedMetrics Drug is used under different interaction scenarios:
For the drug-drug/herbal products interaction. MedMetrics can help using existing records in comparing the ATC code for drug checking. A risk alert will be given when a MedMetrics Drug Passport is paired with the DDD code and the existing ATC code in the MedMetrics Patient Passport.
For the Drug-condition interaction, the ATC code of the new subscripted drug will pair with the DDD code and the ICD code in the MedMetrics Patient Passport and provide a risk alert, respectively.
For people who have an allergy to a specific medication, undertaking drugs with a MedMetrics Drug Passport means their risk of allergy will be reviewed before subscription. Many medicines are branded in different names in the pharmaceutical industry while having similar chemistry comments.
In conclusion, this innovative MedMetrics Drug Passport can help save people’s lives, especially for the elderly or the cohort under medication treatment.
In 2009, the Journal of New England of Medicine had published a Perspective paper on the health information economy [12]. In this sub-section, I have listed the categories of substitutable applications with selected examples—these examples were chosen to demonstrate how MedMetrics performs in the laboratory, clinical practice, hospital, and home-monitoring environment. Combining these exemplars can form different applications that fit a majority of needs in medical and healthcare environments (Table 1).
Purpose of applications | Case studies | MedMetrics empowerment |
---|---|---|
Medication management | Prescribing | Patient identification |
Clinician-order entry | Clinician identification | |
Medication reconciliation | MedMetrics Drug Passport: Dosage comparison from historical records | |
Drug-safety alerts | MedMetrics Drug Passport | |
Documentation | Structured text entry | N/A |
Dictation | N/A | |
Patient management | Disease management | MedMetrics Patient Passport |
Appointment and testing reminders | N/A | |
Care instructions | MedMetrics Patient and Drug Passports | |
Result notification | N/A | |
Patient behaviour modification | N/A | |
Quality improvement | Management of patient transfer and transition | MedMetrics Patient passport |
The Healthcare Effectiveness Data and Information Set (HEDIS) | MedMetrics Patient passport | |
Administrative tools | Billing | N/A |
Referral management | MedMetrics Patient passport | |
Risk stratification | MedMetrics Patient and Drug Passports | |
Communication | Doctor-patient communication | N/A |
Multispecialty or team communication | N/A | |
Patient support | MedMetrics Patient and Drug Passports | |
Patient or clinician social networking | N/A | |
Public health reporting | Notifiable disease reporting | MedMetrics Patient passport |
Biosurveillance | MedMetrics Patient passport | |
Pharmacosurveillance | MedMetrics Drug passport | |
Healthcare Industry | Health insurance | MedMetrics Patient passport |
Medical devices | MedMetrics Patient passport and international standards | |
Emerging technologies and algorithms | MedMetrics Patient and Drug passports |
Categories of substitutable applications, selected examples and MedMetrics [12].
Another main area that MedMetrics can empower is medical science, pharma industry, and scientific biology research. Medicine is increasingly becoming an interdisciplinary area of medical science, surgical intervention, and an information industry identified by governments, healthcare service providers, health product industry, and patients [13]. In Table 2, the author summarised how MedMetrics can contribute to medical science in research, safety, and information transfer.
Purpose of applications | Case studies | MedMetrics empowerment |
---|---|---|
Medical Research | Clinical trial eligibility | MedMetrics Patient passport and international standard |
Cohort study tools | International standards | |
Electronic data capture for trials | International standards | |
Laboratory-test interpretation | International standards | |
Genomics | International standards | |
Guideline management | International standards | |
Data acquisition | Laboratory data feed | |
Dispensed medication feed | Blockchain, MedMetrics Patient and Drug passport | |
Personally controlled health record data feed | Blockchain and MedMetrics Patient | |
Public health data feeds (e.g., local context for infectious diseases) | Blockchain, MedMetrics Patient and Drug passport |
MedMetrics in medical science: Research, safety and information transfer [12].
As shown in Tables 1 and 2, among the purpose of applications, MedMetrics plays a critical role in authorisation, security, and policymaking.
The data structure in the healthcare system is highly correlated and complex. Many vendors provide healthcare solutions that are IT-centered instead of patient-centered. Thanks to the nature of the data structure in the MedMetrics Passports for patients and drugs, AI, Cloud service, Internet of Things (IoT), and blockchain methods will be able to play a significant role in the upcoming digital health revolution. In this section, the author will introduce how MedMetrics will work in EHR, fuse with AI, blockchain, and IoT (e.g., wearable sensors).
Biometric technologies can offer fast and multiple ways of authentication. The encoding and decoding technology have to apply to information that is generated based on the characteristics of objects. Securing electronic health records could become a complex and costly activity, especially in a scenario where multiple actors potentially maintain information [14, 15].
Remote patient monitoring applications mainly focus on connecting clinicians and patients in hospital, community, and home environments. The ultimate goal is to empower both patients and clinicians with timely information for making necessary interventions at an optimised point of service—it will improve the clinical outcome and reduce the risk of burden on the health economics in the long term.
The European Committee for Standardisation has released a set of information security standards to provide a framework for secures to rage and release of health data [16]. The European standards recognise four global security needs that any health information system should accomplish. They are availability, confidentiality, integrity, and accountability [16].
Availability is the main barrier between different hospitals and clinics. The MedMetrics Patient Health Passport, blockchain technology will allow health care providers and governing bodies to re-visit the barrier in patient information availability and consider it an integrated solution.
Confidentiality of patient information is a major concern for patient EHR storage and sharing. One way to deal with it is that users with the right to access patient information need to be authorised and allowed to do so in order to perform their duties. In this case, the principle of need-to-know is the key concept to be applied [17]. The other way is to unlock the information that is required for a specific purpose, instead of at the same level. In any case, the information accessed should be relevant but also sufficient to provide health care services [18]. Having an encrypted MedMetrics code can dilute the concern of fraud but cannot entirely remove the concern of restricting the users.
Integrity is a blade with both sides. A correctly integrated EHR will help clinicians understand patients’ health history with a higher likelihood of making correct clinical interventions. However, a merged patient EHR with a fragment of mixed correct and incorrect will bring uncertainty untold and unseen until the data transformation is done. This can be due to human error from the raw record, but the most challenging part is combining complex historical data among different IT platforms and data structures. The MedMetrics deployed international standards and codes, removing the integrity concern from its root. However, transferring historical data into MedMetrics is yet challenging.
Accountability in ethics and governance is equated with answerability, blameworthiness, liability, and the expectation of account-giving [19]. Accountability is central to the discussion in governance for services in public sectors, nonprofit and private, and individual contexts [20, 21]. The MedMetrics passports for patients and drugs are a secure and comprehensive solution to help deal with the privacy and trustfulness issues in the EHR.
The questions of need-to-know, who-to-know, when-to-know, where-to-know are all driven by the relevance of the acceded information. Defining the correct balance between security requirements and the availability of information is a critical goal in a complex healthcare environment [22]. Relevancy is an ambiguous concept that depends on the context. Having a Medimetrics and biometrics authentication of users makes it possible to guarantee that information is accessed, added, and un-modified by the authorised party.
The figure below demonstrates the principle of MedMetrics and how it might work in the healthcare system (Figure 2).
MedMetrics data pipeline in healthcare.
This sub-section will introduce how AI and blockchain can seamlessly work with the MedMetrics infrastructure. Clinical decision-making support uses AI algorithms to support clinicians, healthcare providers, and insurance companies to make real-time clinical or operational decisions. Some companies have implanted AI in the healthcare pipeline. For example, Sensyne Health is the UK’s first public listed company in clinical AI, partnered with Oxford University Hospitals and the University of Oxford. It provides AI solutions to both life sciences challenges and healthcare solutions. Another example is Nuance, a company that partnered with Microsoft to provide Healthcare AI solutions and services.
MedMetrics is a group of healthcare codes that reflect the uniqueness of patient and drug information. The data structure means it is suitable for natural language processing (NLP) models such as the Bert model [23], a pre-training of deep bidirectional transformers for language understanding. Several Bert models were designed for ICD code. For example, Med-Bert is a method that uses pre-trained contextualised embedding on large-scale structured electronic health records for disease prediction [24]. BEHRT is a deep neural sequence transduction model for EHR that simultaneously predicts the likelihood of 301 conditions in one’s future visits [25]. Med-BERT used ICD-9 and ICD-10 codes for diagnosis and the BEHRT used the Clinical Practice Research Datalink (CPRD). The CPRD contains longitudinal primary care covering 35 million patients in the UK. Both Med-BERT and BEHRT proved to be a powerful tools in transferring reactive treatment into preventive medicine at the national level.
Federated learning is a learning paradigm seeking to address the problem of data governance and privacy by training algorithms collaboratively without exchanging the data itself [26]. Given that scores of data are widely spread across hospitals/individuals, a decentralised computationally scalable methodology is needed [27].
The combination of MedMetrics and Federate Learning will benefit disease prediction studies with small local training datasets, reduce data collection expenses, and accelerate the pace of artificial intelligence-aided healthcare. It will help deal with multi-arm clinical studies across different counties (hence have different data privacy policies) and develop predictive models that require data feeding from time to time.
Body Sensor Network (BSN) [28] is one of the most exciting concepts in patient home monitoring. It builds a continuous information hub that can provide real-time and long-distance monitoring. The usage of BSN is still a relatively new area in biometrics. There is a great potential for using one or multiple BSN for personnel identification in healthcare settings.
One of the most mature areas in physiological sensor data biometrics is ECG biometrics. ECG has emerged as a biometrics method with promising results. But same as other sensor technologies, the measurement signals come with sensor failures and measurement variance. On an individual basis, ECG signals can be influenced by physical and psychological changes, such as emotional and mental states, exercise, body position, diets, physical diseases, and positions of electrodes [5]. In addition, signal-acquisition devices produce noises such as from power line interference, baseline wandering, and electrode motion artefacts [29]. Therefore, future work in ECG biometric algorithms is still needed to deal with the concurrence of noises and sample variation.
In applications using ECG as biometrics measures, technologies such as convolutional neural network (CNN), recurrent neural network (RNN), graph regularised non-negative matrix factorisation and sparse representation, One-Dimensional Multi-Resolution Local Binary Patterns, and multi-feature collective non-negative matrix factorisation have been used for pattern recognition (Figure 3) [30, 31, 32, 33, 34, 35].
Examples of deep learning infrastructure for ECG authorisation. (a) an example of a CNN infrastructure, (b) an example of an RNN infrastructure [
Telemedicine, telehealth, EHR systems, automated retrieval, or update of the electronically stored patient data are common issues that restrict data sharing in the medical science and healthcare sector. Blockchain is a technology in data encryption/decryption and tracking. It accelerates innovation, enhances trust, and improves efficiency by overcoming data openness, transparency, and trust concerns. Research suggested that the blockchain might transform how decisions and the interactions between clinicians and patients are recorded [36]. Digital medicine is a field concerned with the use of technologies as tools for measurement and intervention in the service of human health [37]. In the digital medicine environment, blockchain technology will provide AI-based algorithms and applications with the guardian of privacy and authenticity [38].
Due to the size of ever-growing patient data and the future-proof institutional and nationwide service infrastructure, technology developers and health service providers gradually moved towards cloud service. The advancement in cloud networks has enabled connectivity of both traditional networked elements and new devices from IoT [39]. The governance and standard in supporting Cloud service are ready in taking on new healthcare applications. For the Cloud Service, Health Level Seven International (HL7) framework is a globally accepted standard. HL7 is the global authority on standards for interoperability of health technology with members in over 55 countries [40]. Moreover, the Fast Healthcare Interoperability Resources (FHIR) is a standards framework created by HL7 that combines HL7, CDA product lines and web standards.
By using MedMetrics and blockchain, the internationally identifiable MedMetrics code will provide a seamless solution to make patient data transferable, traceable, and interoperable between hospitals and different countries.
Clinical science and medical research in healthcare is an evidence-based practice. The three main pillars for the next generation of digital health and the medical information revolution are securely encrypted data (e.g. using blockchain), artificial intelligence, and governance standard and regulations. The information governance, patient health and safety, ethics and fairness, and economic cost all suggest that a more internationally agreed and unified measure is required to support the upcoming digital health revolution.
Biometrics technologies have been broadly used in the public sectors, including the army, door entry, and data access systems, in authorising personnel access and data access for employees. However, in the healthcare sector, biometrics technologies are mainly used by doctors to access patient information (using user names and fingerprints for one-to-one authorisation). There is an emerging trend of using face recognition to log into online health services, but it is more to combine with mobile authorisation, such as Apple face recognition plug-in, instead of healthcare provider.
The slow movement of using biometrics in the health and care sectors is mainly due to the lack of regulation and policy support for patient data protection. There are hundreds of applications available in the commercial market to suggest they can provide healthcare biometrics solutions in hospitals, doctor’s offices, and patient’s mobile devices for patient data access control. However, the path of transferring patient EHR among devices, platforms, and hospitals is unclear at the law and regulation level. Due to this reason, most biometrics applications are based on individual hospitals, certain medical procedures, or specific clinics. The legal developments in healthcare have been driven by the public concern for personal privacy and confidentiality.
The MedMetrics passports for patients and drugs will help enable and scale up the innovation in the digital health industry. The MedMetrics Drug Passport can avoid preventable medical procedure mistakes, such as giving the wrong medication. By combining with the blockchain, the MedMetrics Patient Passport can provide a secure healthcare data storage and transfer infrastructure.
Beyond the novel solution in dealing with data privacy, the MedMetrics Patient and Drug Passports will help prevent fraud. The technical challenge of these paradigm shifts is interoperability for supporting the delivery of care at multiple locations by multiple carers who need to share the patient health record [41]. By applying AI algorithms, MedMetrics can identify patients with different health conditions as recorded in the previous record. This will help to prevent fraud in health insurance. By combing an AI layer, the MedMetrics can also alert clinicians when the newly collected MedMetrics information is largely different from the previous record, which means that patient may need a medical review. The concept of MedMetrics and its deployment will change the user demographic of healthcare applications that healthcare providers would fuse into their clinical practice based on the current healthcare regulations. The developments in standardisation within digital health will help lower long-term costs in public health and improve the quality of healthcare.
In conclusion, biometrics in medical science is an emerging area. The benefits of using biometric identity verification for healthcare are increasing thanks to emerging technologies in blockchain, IoT, fast-speed mobile networks, and more and more powerful mobile phone devices. However, safely implementing biometrics technologies in applications, especially in healthcare and medical settings, is still more prominent in response to a government-led, regulation-based infrastructure. The concept of MedMetrics can change the user demographic, shift safety restrictions, define new user applications, and encourage ethical AI regulations in medical science and health care. It will boost the next generation of biometrics in medical science and health care and encourage hospital-centered, patient-centered, or service-catered applications.
The author thanks Prof. David Clifton for mentoring and supporting her in the Daphne Jackson and Royal Academy of Engineering Career re-entry Fellowship. The author thanks Prof. Chris Chatwin, Dr. Rupert Young, Department of Engineering and Design, University of Sussex, United Kingdom, for their supervision in my D.Phil study on mobile iris biometrics.
This work was supported by the Royal Academy of Engineering, Daphne Jackson Trust, Oxford John Fell Fund (0011028), Wellcome Trust (217650/Z/19/Z) for their funding support.
The author declares no conflict of interest.
Some desirable properties of medical fibers include non-toxicity strength ability, biocompatibility, biodegradability, good absorbability, softness and freedom from additives and contaminates. The textile material and scientification technics has used generally in medical, surgical application like strength, flexibility, comfort and antimicrobial performances. The basically medical material products are made to multifilament and monofilament yarn, these are made by knitted, nonwoven, woven, braided fabrics and composite structures [1]. The term medical textile literally means textile used for medical purposes. Newsday around the world in textile industries are more growing part of the medical sectors and hygiene products. Medical textiles represent one of the maximum dynamic studies fields` features of technical textiles and its variety of applications. They constitute systems designed and done for a scientific application (intra body/greater body, implantable and non-implantable) textiles utilized in organic structures to estimate, treat, growth or regenerate a tissue, organ or characteristic of the body (plaster, dressings, bandages, strain garments) [2].
Absorbency, high flexibility, softness, high strength, non-toxicity and biocompatibility of textile materials are the key factors which has fuelled the growth of the textiles for its use in implantable, non-implantable, extracorporeal and hygienic products1. Although the natural way to replace a defective body part is the transplantation method, however owing to a number of incentives counting availability this is not always possible thus implantable textiles in the form of fiber and fabric are used in effective repair to the body. Sutures, soft tissue implants, orthopedic and cardiovascular grafting are the implantable textiles which has helped medical science in achieving unparalleled success in recent times [3, 4]. Non-implantable substances are utilized in outside packages, which can also additionally or might not keep in touch with the skin. The substances used must be nonallergenic, anti-cancer, anti-bacterial, permeable to air have a very good capacity to take in liquids, excessive capillarity and wettability, permit moisture shipping and feature the capacity to be sterilized. The foremost packages of those substances confer with wound care and bandages. These materials can be classified into two separated and specialization areas of application. Implantable materials: sutures or wound closure, vascular grafts, artificial ligaments, artificial joints. Non-implantable materials: wound dressing, bandages, plasters, pressure garments, orthopedic belts etc.
These are used for replacing diseased organ or tissue within the body. These replacements must be non-toxic and biocompatible. The implants are normally used for replacing arteries, heart valves, joints etc. Two types of fibers are used for implantable textile.
These are the fibers which are degraded by biological conditions within 2–3 months and mostly used inside the body. These include collagen, alginate, polyactide, polyglycolide, polyamine and some polyurethane [5, 6].
These are the fibers which are not degraded by biological condition for a long time and mostly used for external purposes. These include polytetrafluoroethylene (PTFE), polyester, polypropylene, carbon and others.
Factors which are important for implantable textiles are:
Biocompatibility and biostability
The properties of polyester will influence the success of implantation in terms of biodegradability (Tables 1 and 2).
Parameters | Fiber type | Fabric type |
---|---|---|
Cardiovascular implants, vascular grafts, heart valves | Polyester, PTFE | Knitted, woven |
Artificial tendons, artificial ligaments, artificial skin, artificial lumen, eye contact lenses etc. | PTFE, polyester, polyamide, silk, carbon, etc. | Woven, braided |
Sutures thread | Collagen, polylactide, polyglycolide, polyester, polyamide, PTFE, polypropylene, polyethylene | Mono-filament, braided |
Orthopedic implants, artificial joints, artificial bones etc. | Silicone, polyacetal, polyethylene, polysulphone, carbon, polyester, glass, ceramic | Composite |
Application | Implant |
---|---|
Abdominal wall, hernia | Meshes, patches |
Blood vessel | Tubular prostheses (woven, knitted, nonwoven), stents, stent graft coatings |
Dura | Patches (nonwoven) |
Heart | Patches, occluder, suturing ring of valves |
Osteosynthesis | Fiber reinforced devices, cords for fixation |
Tendon/ligament | Reinforcement |
Trachea, esophagus | Prostheses |
Suture is a generic term for all materials used to bring the served body tissue together and to hold these tissues in their normal position until healing takes place. Sutures are threads that are used as the way of repairing damaged tissues, cut vessels and surgical incisions by uniting the basic edges of the wounds in their required sites. It provides the necessary strength and a temporary barrier to prevent the unwanted infection. The key qualities stimulating the suture design are universal applicability, easy to handle, no kinks, coiling, twisting, or levitating, biocompatibility, inertness, uniformity in tensile strength in terms of suture type and size, frictionless surface to glide through tissue high friction for secure knotting, sterilizable without composition changes, complete absorption i.e. no residue after healing. A suture is a thread that both approximated and maintains tissues until the natural healing process has provided a sufficient level of wound strength or compresses blood vessels in order to stop bleeding. Sutures for wound closure are either monofilament or multifilament threads twisted, spun together or braided. They can also be dyed, undyed, coated or uncoated [7]. Patients’ safety is major factor for application of a suture. An incision into the lung would need to be closed using a suture with a high elasticity level, slow degradation rate and high tensile strength level. So, a surgery is never successful if the wound is not sutured or closed in a proper manner as to promote healing in a timely and safe fashion also if the suture of a rough morphology (e.g. braided) the tissue will swell more and more susceptible to infection than if a smooth suture (e.g. monofilament) is used [8].
The classification of the sutures may be done as follows into two types depending on their nature and structure:
Assimilated type of sutures is intended to be absorbed by the body i.e. to be broken down in the body and a second surgery for their removal is not desired. e.g. catgut, collagen and poly glycolic acid. Catgut is one of the most commonly used materials for the manufacture of sutures and is extracted from the ox bone. Being highly absorbable it can also be implanted in the human body even in the case of an infection however its strength deteriorates to half after a week in the body, regardless of the fact that 3 weeks are required for the recovery of an incision after surgery [9].
Non-assimilated types of sutures are considered to be implanted for long term and need to be removed latter. (E.g. cotton, silk, polyester, polyamide and polyethylene.) Cotton sutures necessitate meticulous aseptic technique during use. The main benefit of such sutures is that they are not irritant and the shortcoming is that it is the weakest suture material. Despite the possession of necessary physical form, compatibility and mechanical properties, the very slow biodegradation of the silk filament and the need for the surgical removal is the main draw back in many applications (Figure 1) [10].
Nylon monofilament suture [
The different types of suture include monofilament suture, a braided suture, a pseudo monofilament suture and a twisted strand suture each having its own positive and negative points. Monofilament sutures are made of a single filament of polyester, polyamide, polypropylene or polydioxanone and offer smooth suture drag and low tissue drag. Using such sutures, it is easy to make or place a knot in the depth of the body although the security and the flexibility of the knot are low. In braided type of sutures 8–16 polyester, polyamide or silk monofilaments are braided and coated with a lubricant to increase the flexibility and handle of the sutures. A pseudo monofilament sutures have a core of several twisted materials coated with an extrusion of the same material. It offers low tissue drag, good knottability, low knot security and fair flexibility.
The basically are used sutures in the surgical operation and other injuries. The basically are used suture thread length to tie blood vessels or sew tissues part of body. The many types of suture threads are used as absorbable performance characteristics. All this absorbable intelligent materials technique in sutures are very good working and this is doing better performance in medical sectors. This types all material are used biodegradable and biocompatible polymer. The generally many types of absorbable suture are used made from synthetic polymers.
The soft tissues are utilization in biomedical materials application like artificial tender, artificial corners and artificial prosthness etc. There are two main thrust of tissue engineering research. They are (i) the in vivo route and (ii) the in vitro approach. The objective of in vivo route is to initiate tissue engineering therapies inside the body for the repair and regeneration of damaged or diseased tissue. This approach can be successful for blood cell and nerve regeneration (both peripherial and spiral cord), skin repair, remodeling of defective bone, cornea and retina and for repairing damaged myocardium (heart muscle) following a myocardial infarction (heart attack). Not all diseases and injuries can be controlled by in vivo therapies. For example use in complex tissue cultures for the production of enzymes, drug and growth factors and for toxicological and pharmacological assays. It is depending on the medical sectors application. Ligament implants are carried out to provide autologous transplant reinforcement in construction or to cure the functional residual instabilities. These implants are either made by the braiding process or by the special flat knitting process and high tenacity polyethylene terephthalate or high tenacity polypropylene multifilament are used in making the implants for the artificial ligaments (Figure 2) [11].
Woven ligament structure [
Hard tissue compatible materials must have excellent mechanical properties compatible to hard tissue. Textile structural composites are used for implants. Typical characteristics of polymer related to hard tissue replacement are good processability, chemical stability and biocompatibility. Applications include artificial bone, bone cement and artificial joints. The current practice is to combine bioactive ceramics with polymers or metals to improve interfacial properties. Fiber reinforced composite material may be designed with the required high structure strength and biocompatibility properties needed for these application and are now replacing metal implants for artificial joints and bones.
Orthopedics is a branch of medicine that deals with disorders with the bones, joints and associated muscles. Orthopedic implants generally serve two purposes, as hard tissue to replace bones and joints, and as fixation plates to stabilize fractured bones. The first orthopedic implants were mainly metal structures. Fracture fixation devices include, spinal fixation devices, fracture plates, wires, pins and screws, adhesives while joint replacement hip, knee, elbow, wrist and finger (Figure 3).
Hip bone implants [
The fiber types used for orthopedic implants include polyacetal, polypropylene, and silicone. Composite structures composed of poly (d, l-lactide urethane) and reinforced with polyglycolic acid have excellent physical properties. This sensor principle is designed to allow for a relative strain resolution as small as 10-4–10-5.
Due to a steadily growing number of patients and considerable diagnostic and therapeutic advances, vascular diseases are becoming more and more important in general and clinical practices thus the vascular grafts are the need of the hour. Vascular grafts are used in surgery to replace damaged thick arteries or veins. The implantation of synthetic and biological grafts in the circulatory system yield several types of complications ranging from infection to wall rupture. Dilation, suture line failure, structural defects (holes, perforations, rents, and slits), bleeding and infection are some of the main problems caused due to the failure of the grafts. Textile structures are usually the materials used for arterial replacement; however, they do not always meet all the requirements. Gel weave is a true zero-porosity twill woven polyester graft. It is manufactured using an advanced technique of weaving fully texturized polyester on modern looms (Figure 4) [12].
Knitted structure for a cardiovascular implant [
The most important aspects of an arterial graft include porosity, compliance, and biodegradability and the design considerations for the graft are selection of the right type of polymer, the type of the yarn, fabric and the crimping. Polyester (e.g. Dacron) or PTFE (e.g. Teflon) and polyurethane are the most commonly. Commercial prostheses contain either single- or two-ply yarns. On one hand these yarns usually have a round cross-section and on the other hand trilobal yarns have been used for the reason it provides the advantage of offering a large surface area making the preclott easier and faster, but they are more prone to fatigue and mechanical damage [13, 14].
These are the materials which are used for external applications on the body and may or may not make contact with skin. This includes:
Wound care
Plasters
Orthopedic belts
Wadding
Protective eye pads
Absorbent, wicking performance, non-toxic, breathability, soft, elasticity, non-allergic, ability to be sterilize etc (Table 3).
Application | Fiber types | Fabric structure |
---|---|---|
Absorbent pads | Cotton, viscose, lyocell | Non-woven |
Wound contact layer | Alginate fiber, chitosan, silk, lyocell, cotton, viscose | Non-woven, woven knitted |
Base layer | Viscose, lyocell, plastic film | Non-woven, woven |
Simple non-elastic and non-elastic bandages | Cotton, viscose, lyocell, polyamide fiber, elastomeric fiber yarns | Non-woven, woven |
High–support bandages | Cotton, viscose, lyocell, elastomeric fiber yarns | Non-woven, woven knitted |
Compression bandages | Cotton, viscose, lyocell, elastomeric fiber yarns | Non-woven, woven knitted |
Orthopedic bandages | Cotton, viscose, lyocell, PET, PP, polyurethane form | Woven, knitted |
Plaster | Cotton, viscose, lyocell, PET, PP, glass fiber | Non-woven, woven knitted |
Gauges | Alginate fiber, chitosan, lyocell, cotton, viscose | Non-woven, woven knitted |
Wadding | Viscose, cotton linter, wood pulp | Nonwoven |
Lint | Cotton | Woven |
Different types of dressings are available for a variety of medical and surgical applications.
Functions of wound dressings:
Protection against infection
Absorb blood and exudate
Promote healing
To keep the wound smooth and pliable
Medication to the wound
The wound contact layer should prevent adherence of the dressing to the wound and be easily removed without disturbing new tissue growth. Gauge and paraffin coated gauge are the most common dressings used. Most gauges are made from cotton in the form of a loose plain weave. The burns and skin graft sites must have their dressing changed frequency. When the dressing is removed, it is not only painful, but it can also destroy the regenerating tissues. This can delay the healing process because scarring and reopen the wounds for possible bacteria entrance. The paraffin coated gauge which is usually multilayered is a little easier to remove than dry gauge. Gauge may be impregnated with plaster sterilization is required. Finishing agents such as wetting agents and optical whiteners are not added to gauge fabrics because of the possibility of irritation and possible carcinogenic effects [15, 16].
Nonwoven fabrics can be used for the following advantages:
Better sterilization
Smooth and lint free (allows for a lesser change for debris to be left in the wound)
Can be made softer and more absorbent by latex or thermal calendering
For port operative dressing, sophisticated nonwoven structure is possible. Nonwoven fabrics made of atelocollagen filaments are used as wound dressing for burns.
Polypropylene fabric/carbonized rayon fabric would transmit liquid to the absorbent material and enable to keep the skin dry.
Wound dressings act as physical barrier for wounds and are found to have some distinguished Properties like fluid control, odor management, and microbial control and wound healing acceleration (Table 4).
Types | Properties |
---|---|
Passive products | Traditional dressing that provide cover over the wound |
Interactive products | Polymeric film to permeable to oxygen but not bacteria |
Bioactive products | Dressing that deliver substance active in healing, e.g. alginate, chitogan |
The basically raw material for the product of this fiber is alginic acid, an emulsion attained from the marine brown algae. It possesses a variety of parcels, including the capability to stabilize thick suspense, to form film layers, and to turn into gels. When the dressing made of this fiber is applied to crack, the rear ion exchange take place and this fiber is placed on the crack in dry state and begin to absorb the exudates.
It is a supple, non-woven dressing made from high quality calcium alginate fiber with excellent gel forming properties A Sorbalgon dressing absorbs approximately 10 ml exudates per gram dry weight (Figure 5).
Sorbalgon wound dressing [
Thin film has very superior absorbent properties and outer surface thin film give better comfort behavior. This thin layer film has basically working of the easily absorb body fluid and proper safe keep it to the dressing leakage and wound maceration.
Acticoat dressing is give better protection against fungal infection performance as compared to traditional antimicrobial dressing materials. This dressing is better kill rate and more effective fungal species.
The bandage has generally essential properties should be like breathable, stretchable, non-slip, non-stick to more comfort help during injuries time of human body. Bandages are designed to perform a whole variety of specific functions depending upon the final medical requirement. The basically bandages are used in injuries and wound place to keep it dressing. Such bandages are in form of light-weight knitted fabrics or open-weave woven fabrics, made from either cotton or viscose. Their primary function is to hold the healing wound dressings firmly in place. They themselves do not have healing functions to play [17, 18].
Orthopedic cushion bandages are used under plaster casts and compression bandages to prove padding and prevent discomfort.
Different types of bandages can be classified.
It provides necessary support to circumscribe movement and speed up the mending process Compression tapes are used for the treatment and forestallment of deep tone thrombosis, leg ulceration, and swollen modes and are designed to ply a needed quantum of contraction on the leg when applied at a constant pressure. Compression tapes are classified by the quantum of contraction they can play at the ankle and include extra-high, high, moderate, and light contraction and can be either woven and contain cotton and elastomeric yarns or underpinning and weft knitted in both tubular or completely-fashioned forms.
Compression hosiery can be used as an alternative to compression bandaging for the treatment of active ulcers.
Compression hosiery is classified according to the pressure level applied at the ankle.
Compression hosiery is made from a number of different fibers including nylon, cotton yarn and elastane.
A cloth girth saturated with cataplasm of Paris is dipped into water and also wrapped around the broken branch thereby creating an establishment- fitting yet fluently removed flake in the shape of a tube or cylinder. This type of operation of cataplasm in the form of a broken branch is generally known as an orthopedic cast. The modern plaster fabric is made from spun bonded nonwovens of cotton, viscose, polyester or glass fiber (Figure 6) [19].
Orthopedic bandages [
Pressure garments play a vital role in the proper healing of wounds and reduce the effects of scaring, but for the garments to perform their job properly, they need to be in good condition. The continuous wearing of pressure garments prevents the thickening, buckling, and nodular formations seen in hypertrophic scars [20].
Medical textiles have visible speedy improvement over the previous couple of decades. Nowadays, new biodegradable fibers have enabled the improvement of novel sorts of implants, and contemporary-day fabric machines can produce third-dimensional spacer fabric that supply advanced overall performance over conventional fabric materials.
These and lots of different advances have made clinical textiles a crucial detail in contemporary-day ailment management, and they are turning into increasingly critical with the growing quantity of aged humans with inside the populations of evolved countries.
The more significance of medical textiles in human life, healthful residing and development is immense.
The improvement of latest technology and new gadgets will assist sufferers to conquer the hardships that they used to go through with inside the past.
There are many extra unknown regions of medical textiles; we must do studies on the ones issues. We must pay extra interest to the manufacturing of healthful and nice clinical fabric materials. In addition to technology, we want to hold a watch at the rate of our products.
Through this it is going to be viable to supply nice whole and easily to be had contemporary-day medical textiles.
Textile substances preserve to serve a critical feature with inside the improvement of number clinical and surgical products.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. 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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. 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This chapter dwells on the sources and reactivity of phenolic compounds in water, their toxic effects on humans, and methods of their removal from water. Specific emphasis is placed on the techniques of their removal from water with attention on both conventional and advanced methods. Among these methods are ozonation, adsorption, extraction, photocatalytic degradation, biological, electro‐Fenton, adsorption and ion exchange and membrane‐based separation.",book:{id:"6029",slug:"phenolic-compounds-natural-sources-importance-and-applications",title:"Phenolic Compounds",fullTitle:"Phenolic Compounds - Natural Sources, Importance and Applications"},signatures:"William W. Anku, Messai A. Mamo and Penny P. 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Morales and Sagrario Martínez-Ramírez",authors:[{id:"107401",title:"Dr.",name:"Lucia J",middleName:null,surname:"Fernández",slug:"lucia-j-fernandez",fullName:"Lucia J Fernández"}]},{id:"53128",doi:"10.5772/66368",title:"Phenolic Compounds: Functional Properties, Impact of Processing and Bioavailability",slug:"phenolic-compounds-functional-properties-impact-of-processing-and-bioavailability",totalDownloads:9393,totalCrossrefCites:78,totalDimensionsCites:149,abstract:"In this chapter, we discuss the influence of the processing methods on the content of phenolic compounds in fruits and vegetables. The intake of fruits and vegetables based‐foods are associated with delayed aging and a decreased risk of chronic disease development. Fruits and vegetables can be consumed in natura, but the highest amounts are ingested after some processing methods, such as cooking procedures or sanitizing methods. These methods are directly methods are directly related to alteration on the phenolic content. In addition, the postharvest conditions may modify several phytochemical substances. Phenolic compounds are referred to as phytochemicals found in a large number of foods and beverages. The relative high diversity of these molecules produced by plants must be taken into account when methods of preparation are employed to obtain industrial or homemade products. Phenolic compounds comprise one (phenolic acids) or more (polyphenols) aromatic rings with attached hydroxyl groups in their structures. Their antioxidant capacities are related to these hydroxyl groups and phenolic rings. Despite the antioxidant activity, they have many other beneficial effects on human health. However, before attributing health benefits to these compounds, absorption, distribution, and metabolism of each phenolic compound in the body are important points that should be considered.",book:{id:"5609",slug:"phenolic-compounds-biological-activity",title:"Phenolic Compounds",fullTitle:"Phenolic Compounds - Biological Activity"},signatures:"Igor Otavio Minatel, Cristine Vanz Borges, Maria Izabela Ferreira,\nHector Alonzo Gomez Gomez, Chung-Yen Oliver Chen and\nGiuseppina Pace Pereira Lima",authors:[{id:"146379",title:"Dr.",name:"Giuseppina",middleName:null,surname:"Lima",slug:"giuseppina-lima",fullName:"Giuseppina Lima"},{id:"194002",title:"MSc.",name:"Cristine",middleName:null,surname:"Vanz Borges",slug:"cristine-vanz-borges",fullName:"Cristine Vanz Borges"},{id:"194003",title:"Prof.",name:"Igor Otavio",middleName:null,surname:"Minatel",slug:"igor-otavio-minatel",fullName:"Igor Otavio Minatel"},{id:"194004",title:"Dr.",name:"Maria Izabela",middleName:null,surname:"Ferreira",slug:"maria-izabela-ferreira",fullName:"Maria Izabela Ferreira"},{id:"194005",title:"Prof.",name:"Hector",middleName:null,surname:"Gomez-Gomez",slug:"hector-gomez-gomez",fullName:"Hector Gomez-Gomez"},{id:"194006",title:"Prof.",name:"Chung-Yen Oliver",middleName:null,surname:"Chen",slug:"chung-yen-oliver-chen",fullName:"Chung-Yen Oliver Chen"}]}],mostDownloadedChaptersLast30Days:[{id:"55500",title:"Interpretation of Mass Spectra",slug:"interpretation-of-mass-spectra",totalDownloads:12503,totalCrossrefCites:12,totalDimensionsCites:25,abstract:"The chapter includes an introduction to the main ionisation techniques in mass spectrometry and the way the resulting fragments can be analysed. First, the fundamental notions of mass spectrometry are explained, so that the reader can easily cover this chapter (graphs, main pick, molecular ion, illogical pick, nitrogen rule, etc.). Isotopic percentage and nominal mass calculation are also explained along with fragmentation mechanism. A paragraph emphasises the ionisation energy issues, the basics of ionisation voltage, the developing potential and the energy balance. A frame time of the main theoretical milestones in both theory and experimental mass spectrometry is highlighted here. In the second part of the chapter, the molecular fragmentation for alkanes, iso-alkanes, cycloalkanes, halogen, alcohols, phenols, ethers, carbonyl compounds, carboxylic acids and functional derivatives, nitrogen compounds (amines, nitro compounds), sulphur compounds, heterocycles and biomolecules (amino acids, steroids, triglycerides) is explained. Fragmentation schemes are followed by the simplified spectra, which help the understanding of such complex phenomena. At the end of the chapter, acquisition of mass spectrum is discussed. The chapter presented here is an introduction to mass spectrometry, which, we think, helps the understanding of the mechanism of fragmentation corroborating spectral data and molecular structures.",book:{id:"5735",slug:"mass-spectrometry",title:"Mass Spectrometry",fullTitle:"Mass Spectrometry"},signatures:"Teodor Octavian Nicolescu",authors:[{id:"196775",title:"Dr.",name:"Teodor Octavian",middleName:"Octavian",surname:"Nicolescu",slug:"teodor-octavian-nicolescu",fullName:"Teodor Octavian Nicolescu"}]},{id:"57909",title:"Validation of Analytical Methods",slug:"validation-of-analytical-methods",totalDownloads:6989,totalCrossrefCites:13,totalDimensionsCites:21,abstract:"Method validation is a key element in the establishment of reference methods and within the assessment of a laboratory’s competence in generating dependable analytical records. Validation has been placed within the context of the procedure, generating chemical data. Analytical method validation, thinking about the maximum relevant processes for checking the best parameters of analytical methods, using numerous relevant overall performance indicators inclusive of selectivity, specificity, accuracy, precision, linearity, range, limit of detection (LOD), limit of quantification (LOQ), ruggedness, and robustness are severely discussed in an effort to prevent their misguided utilization and ensure scientific correctness and consistency among publications.",book:{id:"6379",slug:"calibration-and-validation-of-analytical-methods-a-sampling-of-current-approaches",title:"Calibration and Validation of Analytical Methods",fullTitle:"Calibration and Validation of Analytical Methods - A Sampling of Current Approaches"},signatures:"Tentu Nageswara Rao",authors:[{id:"220824",title:"Dr.",name:"Tentu",middleName:null,surname:"Nageswara Rao",slug:"tentu-nageswara-rao",fullName:"Tentu Nageswara Rao"}]},{id:"55440",title:"Solubility Products and Solubility Concepts",slug:"solubility-products-and-solubility-concepts",totalDownloads:3090,totalCrossrefCites:6,totalDimensionsCites:7,abstract:"The chapter refers to a general concept of solubility product Ksp of sparingly soluble hydroxides and different salts and calculation of solubility of some hydroxides, oxides, and different salts in aqueous media. A (criticized) conventional approach, based on stoichiometry of a reaction notation and the solubility product of a precipitate, is compared with the unconventional/correct approach based on charge and concentration balances and a detailed physicochemical knowledge on the system considered, and calculations realized according to generalized approach to electrolytic systems (GATES) principles. An indisputable advantage of the latter approach is proved in simulation of static or dynamic, two-phase nonredox or redox systems.",book:{id:"5891",slug:"descriptive-inorganic-chemistry-researches-of-metal-compounds",title:"Descriptive Inorganic Chemistry Researches of Metal Compounds",fullTitle:"Descriptive Inorganic Chemistry Researches of Metal Compounds"},signatures:"Anna Maria Michałowska-Kaczmarczyk, Aneta Spórna-Kucab and\nTadeusz Michałowski",authors:[{id:"35273",title:"Prof.",name:"Tadeusz",middleName:null,surname:"Michalowski",slug:"tadeusz-michalowski",fullName:"Tadeusz Michalowski"},{id:"203867",title:"Dr.",name:"Anna Maria",middleName:null,surname:"Michałowska-Kaczmarczyk",slug:"anna-maria-michalowska-kaczmarczyk",fullName:"Anna Maria Michałowska-Kaczmarczyk"},{id:"203868",title:"Dr.",name:"Aneta",middleName:null,surname:"Spórna-Kucab",slug:"aneta-sporna-kucab",fullName:"Aneta Spórna-Kucab"}]},{id:"62736",title:"Radioisotope: Applications, Effects, and Occupational Protection",slug:"radioisotope-applications-effects-and-occupational-protection",totalDownloads:4543,totalCrossrefCites:10,totalDimensionsCites:17,abstract:"This chapter presents a brief introduction to radioisotopes, sources and types of radiation, applications, effects, and occupational protection. The natural and artificial sources of radiations are discussed with special reference to natural radioactive decay series and artificial radioisotopes. Applications have played significant role in improving the quality of human life. The application of radioisotopes in tracing, radiography, food preservation and sterilization, eradication of insects and pests, medical diagnosis and therapy, and new variety of crops in agricultural field is briefly described. Radiation interacts with matter to produce excitation and ionization of an atom or molecule; as a result physical and biological effects are produced. These effects and mechanisms are discussed. The dosimetric quantities used in radiological protection are described. Radiological protections and the control of occupational and medical exposures are briefly described.",book:{id:"5903",slug:"principles-and-applications-in-nuclear-engineering-radiation-effects-thermal-hydraulics-radionuclide-migration-in-the-environment",title:"Principles and Applications in Nuclear Engineering",fullTitle:"Principles and Applications in Nuclear Engineering - Radiation Effects, Thermal Hydraulics, Radionuclide Migration in the Environment"},signatures:"Sannappa Jadiyappa",authors:[{id:"239626",title:"Dr.",name:null,middleName:null,surname:"Sannappa J.",slug:"sannappa-j.",fullName:"Sannappa J."}]},{id:"58596",title:"Linearity of Calibration Curves for Analytical Methods: A Review of Criteria for Assessment of Method Reliability",slug:"linearity-of-calibration-curves-for-analytical-methods-a-review-of-criteria-for-assessment-of-method",totalDownloads:8095,totalCrossrefCites:19,totalDimensionsCites:44,abstract:"Calibration curve is a regression model used to predict the unknown concentrations of analytes of interest based on the response of the instrument to the known standards. Some statistical analyses are required to choose the best model fitting to the experimental data and also evaluate the linearity and homoscedasticity of the calibration curve. Using an internal standard corrects for the loss of analyte during sample preparation and analysis provided that it is selected appropriately. After the best regression model is selected, the analytical method needs to be validated using quality control (QC) samples prepared and stored in the same temperature as intended for the study samples. Most of the international guidelines require that the parameters, including linearity, specificity, selectivity, accuracy, precision, lower limit of quantification (LLOQ), matrix effect and stability, be assessed during validation. Despite the highly regulated area, some challenges still exist regarding the validation of some analytical methods including methods when no analyte-free matrix is available.",book:{id:"6379",slug:"calibration-and-validation-of-analytical-methods-a-sampling-of-current-approaches",title:"Calibration and Validation of Analytical Methods",fullTitle:"Calibration and Validation of Analytical Methods - A Sampling of Current Approaches"},signatures:"Seyed Mojtaba Moosavi and Sussan Ghassabian",authors:[{id:"216099",title:"Dr.",name:"Sussan",middleName:null,surname:"Ghassabian",slug:"sussan-ghassabian",fullName:"Sussan Ghassabian"},{id:"216101",title:"Mr.",name:"Seyed Mojtaba",middleName:null,surname:"Moosavi",slug:"seyed-mojtaba-moosavi",fullName:"Seyed Mojtaba Moosavi"}]}],onlineFirstChaptersFilter:{topicId:"8",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"83005",title:"Catalytic Behavior of Extended π-Conjugation in the Kinetics of Sensitizer-Mediator Interaction",slug:"catalytic-behavior-of-extended-conjugation-in-the-kinetics-of-sensitizer-mediator-interaction",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.106511",abstract:"This chapter discusses the catalytic effect of extended π-conjugation on the electron transfer process between ferricyphen-ferrocyanide and ferricypyr-ferrocyanide in an aqueous medium. Ferricyphen and ferricypyr may be feasible options for the sensitizer in dye-sensitized solar cells due to their high reduction potential, stability, capability as an outer-sphere oxidant, and photosensitivity. Meanwhile, ferrocyanide could be used as a mediator in DSSCs instead of iodide to avoid iodate production and achieve a similar reduction potential and stability. This chapter compared the ability of competent putative sensitizers to oxidize the likely mediator in water. In contrast to the 2,2′-dipyridyl chelate, the extended π-conjugation in 1,10-phenanthroline accelerated the redox process by increasing the electron affinity of ferricyphen as compared to ferricypyr. The reactions had the same kinetics but different rate constants, indicating that the ferricyphen-ferrocyanide reaction was several times faster than the ferricypyr-ferrocyanide reaction, revealing and confirming the catalytic influence of extended π-conjugation on the redox process.",book:{id:"11217",title:"Recent Advances in Chemical Kinetics",coverURL:"https://cdn.intechopen.com/books/images_new/11217.jpg"},signatures:"Rozina Khattak"},{id:"83004",title:"Pyridine Heterocycles in the Therapy of Oncological Diseases",slug:"pyridine-heterocycles-in-the-therapy-of-oncological-diseases",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.106406",abstract:"Oncological diseases pose a major challenge for modern medicine. Heterocyclic compounds play a vital role in modern medical and pharmaceutical science as most medicinal substances incorporate them. Nitrogen-containing heterocycles serve as the basis of numerous drugs and, therefore, are deeply involved in the design and synthesis of promising new therapeutic agents. Pyridine or pyrimidine scaffolds, with a number of substituents attached, comprise a large portion of FDA-approved drugs. They are chemically stable in the human body, manifest an affinity for DNA via hydrogen bonding, and present an opportunity for the development of novel anticancer agents. A large number of pyridine-based molecules are synthesized and tested for anticancer activity each year. The present chapter aims to introduce the most current synthetic approaches, published in scientific literature, and would also elaborate on structure-activity relationships described therein.",book:{id:"11562",title:"Chemistry with Pyridine Derivatives",coverURL:"https://cdn.intechopen.com/books/images_new/11562.jpg"},signatures:"Lozan T. Todorov and Irena P. Kostova"},{id:"82969",title:"Utilizing Photocatalysts in Reducing Moisture Absorption in Composites of Natural Fibers",slug:"utilizing-photocatalysts-in-reducing-moisture-absorption-in-composites-of-natural-fibers",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.106543",abstract:"Due to growing environmental consciousness and the depletion of oil supplies, numerous efforts have been made to replace synthetic fibers in fiber-reinforced composites with natural fibers (NFr). The low cost and abundance of NFr and its biodegradability and low density have encouraged researchers worldwide to study their potential applications in several industrial sectors. However, NFr has several disadvantages: excessive moisture absorption and subsequent swelling and degradation, low chemical and fire resistance, and insufficient interfacial interactions with polymers. Consequently, there is great interest in modifying the surface of NFr using a variety of methods. This chapter presents an overview of the NFr, its characterization, the problems associated with adding NFr to polymer composites. This literature survey suggests an in-depth review of photocatalysis by utilizing photocatalysts nanoparticle (PHNPs) aimed at increasing the hydrophobicity and interfacial bonding between the NFr and the matrix Using a photo-induced oxidation mechanism to disassemble water molecules, pollutants, and bacteria in a wet environment. Additionally, we reviewed the effects of these PHNPs on the moisture absorption, mechanical characteristics, and dimensional stability of NFr composites. As a result, this review article may make a valuable contribution to researchers interested in coating and treating NFr to further enhance their surface characteristics.",book:{id:"11559",title:"Photocatalysts - New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11559.jpg"},signatures:"Mohammed Mohammed and Rozyanty Rahman"},{id:"82853",title:"Revealing Retention Mechanisms in Liquid Chromatography: QSRR Approach",slug:"revealing-retention-mechanisms-in-liquid-chromatography-qsrr-approach",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.106245",abstract:"One-factor-at-a-time experimentation was used for a long time as gold-standard optimization for liquid chromatographic (LC) method development. This approach has two downsides as it requires a needlessly great number of experimental runs and it is unable to identify possible factor interactions. At the end of the last century, however, this problem could be solved with the introduction of new chemometric strategies. This chapter aims at presenting quantitative structure–retention relationship (QSRR) models with structuring possibilities, from the point of feature selection through various machine learning algorithms that can be used in model building, for internal and external validation of the proposed models. The presented strategies of QSRR model can be a good starting point for analysts to use and adopt them as a good practice for their applications. QSRR models can be used in predicting the retention behavior of compounds, to point out the molecular features governing the retention, and consequently to gain insight into the retention mechanisms. In terms of these applications, special attention was drawn to modified chromatographic systems, characterized by mobile or stationary phase modifications. Although chromatographic methods are applied in a wide variety of fields, the greatest attention has been devoted to the analysis of pharmaceuticals.",book:{id:"11557",title:"Chemometrics - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11557.jpg"},signatures:"Jovana Krmar, Bojana Svrkota, Nevena Đajić, Jevrem Stojanović, Ana Protić and Biljana Otašević"},{id:"82796",title:"A Revisit of the Underlying Fundamentals in the Laser Emission from BODIPYs",slug:"a-revisit-of-the-underlying-fundamentals-in-the-laser-emission-from-bodipys",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.106334",abstract:"This chapter aims to provide a comprehensive assessment of the laser performance of commercially available laser dyes based on the boron-dipyrromethene (BODIPY) chromophore in a liquid state, as well as to remark the main underlying photophysical signatures triggering such photonic behavior. First, we describe their light absorption and fluorescence properties in solution. This spectroscopic study is supplemented with quantum mechanics calculations and electrochemical measurements. Afterward, the dyes are tested as active media of tunable lasers under transversal pumping. The recorded laser efficiencies and photostabilities are correlated with the registered photophysical properties identifying the main structural guidelines and photonic parameters, which rule the laser bands’ position, intensity, and stability. As a result, we provide a comparative dataset of the laser performance, not available hitherto. Besides, the unraveling of the complex molecular structure-photophysics-laser relationship should help in the rational design of new tunable dye lasers with an improved photonic response along the entire visible region and reaching eventually the near infrared.",book:{id:"12081",title:"Dyes and Pigments - Insights and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/12081.jpg"},signatures:"Alaitz Peñafiel, Ainhoa Oliden-Sánchez, Edurne Avellanal-Zaballa, Leire Gartzia-Rivero, Rebeca Sola-Llano and Jorge Bañuelos"},{id:"82706",title:"Applications of Near-Infrared Spectroscopy (NIRS) in Fish Value Chain",slug:"applications-of-near-infrared-spectroscopy-nirs-in-fish-value-chain",totalDownloads:18,totalDimensionsCites:0,doi:"10.5772/intechopen.105736",abstract:"Near-infrared spectroscopy (NIRS) has undergone a significant evolution in the last years due to the numerous scientific studies that revealed its potential for industrial applications, attracting a growing interest in the food sector. Furthermore, new advances have allowed the reduction in size and cost of the NIR devices, making them appropriate for on-site determinations. The complex structure of the fish value chain, combined to its high market value, makes this sector particularly vulnerable to fraud and adulteration practices. Also, the perishable nature of fish and fish products, as well as the lack of traceability, arises the urgent need for a fast, reliable and portable tool capable of precisely characterizing the quality and authenticity of the product while also ensuring its safety. In this chapter, the capabilities of NIRS combined to several chemometric techniques for quality, authenticity and safety applications are presented through an extensive review of the most recent research works.",book:{id:"11564",title:"Infrared Spectroscopy - Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11564.jpg"},signatures:"Sonia Nieto-Ortega, Rebeca Lara, Giuseppe Foti, Ángela Melado-Herreros and Idoia Olabarrieta"}],onlineFirstChaptersTotal:58},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:331,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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",coverUrl:"https://cdn.intechopen.com/series/covers/22.jpg",latestPublicationDate:"August 12th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"356540",title:"Prof.",name:"Taufiq",middleName:null,surname:"Choudhry",slug:"taufiq-choudhry",fullName:"Taufiq Choudhry",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000036X2hvQAC/Profile_Picture_2022-03-14T08:58:03.jpg",biography:"Prof. Choudhry holds a BSc degree in Economics from the University of Iowa, as well as a Masters and Ph.D. in Applied Economics from Clemson University, USA. In January 2006, he became a Professor of Finance at the University of Southampton Business School. He was previously a Professor of Finance at the University of Bradford Management School. He has over 80 articles published in international finance and economics journals. His research interests and specialties include financial econometrics, financial economics, international economics and finance, housing markets, financial markets, among others.",institutionString:null,institution:{name:"University of Southampton",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"86",title:"Business and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/86.jpg",isOpenForSubmission:!0,annualVolume:11970,editor:{id:"128342",title:"Prof.",name:"Vito",middleName:null,surname:"Bobek",slug:"vito-bobek",fullName:"Vito Bobek",profilePictureURL:"https://mts.intechopen.com/storage/users/128342/images/system/128342.jpg",biography:"Dr. Vito Bobek works as an international management professor at the University of Applied Sciences FH Joanneum, Graz, Austria. He has published more than 400 works in his academic career and visited twenty-two universities worldwide as a visiting professor. Dr. Bobek is a member of the editorial boards of six international journals and a member of the Strategic Council of the Minister of Foreign Affairs of the Republic of Slovenia. He has a long history in academia, consulting, and entrepreneurship. His own consulting firm, Palemid, has managed twenty significant projects, such as Cooperation Program Interreg V-A (Slovenia-Austria) and Capacity Building for the Serbian Chamber of Enforcement Agents. He has also participated in many international projects in Italy, Germany, Great Britain, the United States, Spain, Turkey, France, Romania, Croatia, Montenegro, Malaysia, and China. 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My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"312999",title:"Dr.",name:"Bernard O.",middleName:null,surname:"Asimeng",slug:"bernard-o.-asimeng",fullName:"Bernard O. 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A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null,series:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517"},editorialBoard:[{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",institutionString:null,institution:{name:"Universidade Paulista",institutionURL:null,country:{name:"Brazil"}}},{id:"191123",title:"Dr.",name:"Juan José",middleName:null,surname:"Valdez-Alarcón",slug:"juan-jose-valdez-alarcon",fullName:"Juan José Valdez-Alarcón",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBfcQAG/Profile_Picture_1631354558068",institutionString:"Universidad Michoacana de San Nicolás de Hidalgo",institution:{name:"Universidad Michoacana de San Nicolás de Hidalgo",institutionURL:null,country:{name:"Mexico"}}},{id:"161556",title:"Dr.",name:"Maria Dos Anjos",middleName:null,surname:"Pires",slug:"maria-dos-anjos-pires",fullName:"Maria Dos Anjos Pires",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS8q2QAC/Profile_Picture_1633432838418",institutionString:null,institution:{name:"University of Trás-os-Montes and Alto Douro",institutionURL:null,country:{name:"Portugal"}}},{id:"209839",title:"Dr.",name:"Marina",middleName:null,surname:"Spinu",slug:"marina-spinu",fullName:"Marina Spinu",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRLXpQAO/Profile_Picture_1630044895475",institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",institutionURL:null,country:{name:"Romania"}}},{id:"92185",title:"Dr.",name:"Sara",middleName:null,surname:"Savic",slug:"sara-savic",fullName:"Sara Savic",profilePictureURL:"https://mts.intechopen.com/storage/users/92185/images/system/92185.jfif",institutionString:'Scientific Veterinary Institute "Novi Sad"',institution:{name:'Scientific Veterinary Institute "Novi Sad"',institutionURL:null,country:{name:"Serbia"}}}]},onlineFirstChapters:{paginationCount:9,paginationItems:[{id:"83075",title:"Practices and Challenges of Community Services at Debre Markos University, Ethiopia: A Case Study",doi:"10.5772/intechopen.105896",signatures:"Adane Mengist",slug:"practices-and-challenges-of-community-services-at-debre-markos-university-ethiopia-a-case-study",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82858",title:"Corporate Social Responsibility a Case of the Provision of Recreational Facilities",doi:"10.5772/intechopen.105608",signatures:"Peter Musa Wash, Shida Irwana Omar, Badaruddin Mohamed and Mohd Ismail Isa",slug:"corporate-social-responsibility-a-case-of-the-provision-of-recreational-facilities",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82405",title:"Does Board Structure Matter in CSR Spending of Commercial Banks? 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