Chapters authored
Experiment and Animal Models of AAA
Introduction: The incidence of abdominal aortic aneurysms has been increasing throughout the world. The etiology and pathophysiology of this disease are very complicated and complex and include biomechanical aspects as well as biological processes. The effect of these mechanisms is the degradation of the aortic wall, which leads to its dilation and rupture. The possibilities for studying such complex pathophysiology in humans are very limited. That is why we use various mathematical models and a number of different animal models of aneurysm. Methods: A summary of the basic characteristics, findings and examples of using the most widely used animal models of abdominal aortic aneurysm. Information has been obtained from our own experience with laboratory animals and from studies published and available on the Pubmed Internet database. The following search terms were used: aneurysm, aorta, animal model and experiment. Conclusion: Animal models of aortic aneurysms are a usable and useful tool in the study of AAA etiopathogenesis. They also serve as a means to find novel therapeutic pathways. Each model, like any animal species, is different and has its own limitations, advantages and disadvantages, which we should always consider during their use and while interpreting the results.
Part of the book: Abdominal Aortic Aneurysm