Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\n
Throughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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\n
1. Introduction
\n
From material science point of view, tendon/ligament and skin tissue are similar in that they are mainly composed of collagen and elastin. Up to 80% of the dry weight is collagen type I. However, their micro and hierarchical structures and functions are very different from each other. Tendon/ligament is composed of densely packed, aligned collagen fiber bundles, whereas skin is composed of a layered structure of collagen random naonfibril network. \nTable 1\n summarizes the key properties of tendon/ligament and skin tissue in human.
\n
\n
\n
\n
\n\n
\n
\n
Tendon/ligament
\n
Skin
\n
\n\n\n
\n
Main composition
\n
>80% Collagen, ∼5% elastin elastin
\n
>80% Collagen, ∼5% elastin
\n
\n
\n
Minor composition
\n
Fibronectin, proteoglycan
\n
Fibronectin, proteoglycan
\n
\n
\n
Main cells
\n
Fibroblast
\n
Fibroblast and keratinocytes
\n
\n
\n
Vasculature
\n
Few
\n
Abundant
\n
\n
\n
Structure
\n
1D Aligned fiber bundles (nano‐macro)
\n
2D random nanofibrils (weave basket pattern)
\n
\n
\n
Mechanical properties
\n
Strong and elastic
\n
Weak and elastic
\n
\n\n
Table 1.
A general comparison of two different connective tissues: tendon/ligament and skin.
\n
The regeneration of a large size, lost tendon/ligament, and skin tissue normally involves a type of stem cells/progenitor cells of endogenous origin or exogenous origin combined with a biomaterial. Stem cells can be derived from tendon/ligament or skin, or from embryo, placenta, adipose tissue, bone marrow, umbilical cord, etc. This review focuses only on regeneration using exogenous stem cells coupled with a biomaterial matrix/carrier implanted to the wound site. Biomaterial can play a key role in protection of the cells from dehydration while it serves as a temporary substrate for stem cells to proliferate, or differentiate, and synthesize tissue‐specific matrix. The morphology, topography, composition, stiffness of biomaterials may play a key role in controlling the differentiation of stem cells, in addition to biochemical factors, mechanical cues, or genetic/cellular cues. This chapter focuses on biomaterial explored for tendon/ligament/skin tissue regeneration applications.
\n
\n
1.1. Research methods
\n
We performed a comprehensive search of PubMed using keywords “tendon,” “ligament,” “skin,” “regeneration,” “scaffold”, over the years 1970–2016. All articles relevant to the subject were retrieved, and their bibliographies hand searched for further references in the context to biomaterials for tendon/ligament/skin regeneration
\n
\n
\n
\n
2. Results
\n
\n
2.1. Biomaterial directly derived from patients
\n
\n
2.1.1. PRP
\n
Platelet‐rich plasma (PRP) is derived from blood and PRP gel is widely used for tendon/ligament repair. Recently, PRP was combined with adipose‐derived stem cells (ADSCs) and it was found that PRP combined with stem cells resulted in improved mechanical strength in a rabbit tendon model compared to PRP gel alone [1]. Similar results were also observed using PRP with tendon‐derived stem cells (TDSCs) [2]. However, in a sheep model, no differences were observed between the PRP group and PRP‐stem cell group [3]. This approach is highly translational, since both autologous stem cells and PRP can be obtained from the same patients. The concern may be the leucocytes‐containing PRP (L‐PRP) that have a catabolic effect, whereas pure PRP (P‐PRP) without leucocytes have anabolic effects and results in over‐proliferation and scar tissue formation. The complex interaction between PRP and stem cells may explain the different preclinical outcome and warrant a large random clinical trial.
\n
\n
\n
2.1.2. Fibrin
\n
Fibrin can be derived from human plasma. After addition of thrombin, it will form a gel, a process used for blood clotting. Stem cells can be added together with fibrin and thrombin and sprayed onto the wound for the promotion of wound closure and healing. The fibrin combined with bone marrow stem cells spray was successfully tested to prevent ulceration and accelerate wound closure in mice [4]. A small human clinical trial showed this approach accelerates wound closure and resurfacing without adverse effects [5]. Poly(ethylene glycol) PEG‐modified fibrin combined with adipose-derived stem cells (ADSCs) also showed promising results in a pig burn model [6].
\n
\n
\n
2.1.3. Amniotic membrane
\n
Human placenta‐derived biomaterial is unique in that it has immune privilege while it contains multiple growth factors. Human ADSCs (hADSCs) seeded onto radiosterilized human amnion are viable and can proliferate. These cells are able to migrate over these scaffolds as demonstrated by using time‐lapse microscopy. In addition, the scaffolds induce hADSCs to secrete interleukin‐10, an important negative regulator of inflammation [7]. This suggests that placenta‐derived biomaterial may be a good substrate for stem cells and used for skin/tendon applications.
\n
3D micronized (300–600 μm) amniotic membrane (mAM) was made by means of repeated freeze‐thawing cycles to deplete cell components and homogenized with a macrohomogenizer in liquid nitrogen. These mAM loaded with epidermal stem cells (ESCs) (ESC‐mAM) was further transplanted to full‐thickness skin defects in nude mice. ESCs survived well and formed a new epidermis. Four weeks after transplantation, papilla‐like structures were observed, and collagen fibers were well and regularly arranged in the newly formed dermal layer. In conclusion, the mAM as a novel natural microcarrier possesses an intact basement membrane structure and bioactivities [8].
\n
\n
\n
\n
2.2. FDA‐approved ECM grafts for tendon augmentation and skin regeneration
\n
A recent study showed that decellularized matrix from different tissues (tendon, bone, and skin) affect the differentiation of stem cell in a different way. Decellularized bone matrix may induce the undesirable osteogenic differentiation of stem cells, while tendon or skin matrix does not have such an effect [9]. The ECM components provide a niche for proper differentiation of stem cells. For example, ECM without biglycan (Bgn) and fibromodulin (Fmod) will affect the differentiation of tendon stem cells by modulating bone morphogenetic protein signaling and impairs tendon formation in vivo [10]. Autologous origin, but decelluarized dermal matrix using trypsin and Trion X‐100, after combined with ADSCs, was found to enhance wound healing in a murine model of a full‐thickness skin defect [11].
\n
Many FDA‐approved human or animal decelluarized tissue matrixes have been approved for direct tendon/ligament/skin repair without any (stem) cells (\nTable 2\n). The key advantages of decellularized tissue grafts are that they largely maintain the main architecture, composition, and mechanical properties of native tissues. These allografts/xenografts are processed to remove immunogenic cells, DNAs, and certain immunogenic molecules. Typical problems are that these grafts are slower to repair the tissue and some fail to restore the proper functions (e.g., scarring). For tissue regeneration using these ECM biological grafts, stem cells may need to be reseeded onto the grafts for recellularization. For a dense tendon allograft, direct cell seeding may be difficult. The recellularization onto the surface may be achieved using a cell‐loaded gel coating [12]. However, it is highly desirable to get cells inside the grafts as well. Thus, ECM grafts may be processed to have a much higher porosity than the original tissue. Proration/incision into the ECM grafts may help the penetration of cells and nutrients. Instead of being coated with cell‐laden gel, an interesting approach is to use a stem cell‐sheet to wrap around a frozen tendon graft for implantation [13]. Interesting, a case report showed that a dermal allograft combined with PRP and autologous mesenchymal stem cells (MSCs) derived from peripheral blood (PB‐MSCs) resulted in enhanced healing of human rotator cuff [14].
\n
\n
\n
\n\n
\n
Alloderm
\n
Human skin (decelluarized)
\n
\n
\n
GraftJacket
\n
Human skin
\n
\n
\n
Restore
\n
10‐layered porcine small intestine submucosa (SIS) treated with peracetic acid/ethanol (90% collagen, 5–10% lipids)
Porcine acelluar dermis treated with trypsin, solvent, and crosslinked with hexamethylene diisocyanate (HMDI)
\n
\n
\n
Strattice
\n
Porcine acelluar dermal matrix
\n
\n
\n
Cuffpatch
\n
EDC‐crosslinked matrix from eight layers of treated SIS (97% collagen, 2% elastin)
\n
\n
\n
OrthoADAPT
\n
Crosslinked equine pericardium (90% collagen I, 10% collagen II)
\n
\n\n
Table 2.
An example list of biologic ECM grafts with potential for tendon/skin regeneration.
\n
Some of the FDA‐approved ECM biomatrices were combined with stem cells, and investigated for tendon/ligament/skin regeneration applications. Human acellular allograft (Alloderm) was investigated for direct cell seeding using ADSCs. It was concluded that human ADSCs can attach to Alloderm with the dermis side up in a petri dish [15]. ADSC seeded onto Alloderm was also implanted in vivo for skin regenerations with promising results [16]. Strattice was evaluated for seeding with rat MSCs [17]. Thus, the stem cell‐seeded biologic graft can be used as a tendon wrap or a skin regeneration material. A study was performed to compare the survival and proliferation of stem cells via bioluminescent imaging. The use of biologic graft patch (SIS) as carrier of ADSCs significantly increases the survival of stem cells as compared to direct injection of ADSCs into the skin wounds [18]. There may be a synergistic angiogenesis promoting effects of biologic graft with stem cells, which may be important for tendon/skin wound healing [19].
\n
Another interesting approach is to use ECM directly secreted by the cells as a carrier for stem cells. For example, stem cells can be incubated at 37°C in a temperature‐responsive flask (e.g., upcellTM, Cellseed, Japan) and they will product ECM after addition of ascorbic acid. The cell sheets can be lifted at room temperature since the Poly‐n‐isopropylacrylamide (Poly‐NIPAM)‐based substrate will become soluble at lower temperature. The cell‐ECM sheet has been explored for promotion of tendon/ligament healing [20] as well as diabetic skin wound healing [21].
\n
\n
\n
2.3. FDA‐approved biomaterial
\n
\n
2.3.1. Collagen sponge scaffold
\n
(5 mm × 2 mm) collagen sponge scaffolds (Zimmer Dental) were used for the culture of (BM) MSCs. Cell‐seeded scaffolds were placed in culture dishes and incubated for 2 hours in a minimum volume of growth medium, after which more medium was applied to submerge the scaffolds. After an additional 24‐hour culture, cells seeded in scaffolds were treated with 10 ng/mL of recombinant (BMP) 12 for 12 hours. The medium was then replaced with fresh growth medium and scaffolds were either cultured for an additional 7 days or immediately implanted into partial calcaneal tendon defects in rats. It was shown that after 21 days, the BMP12‐treated, collagen‐cell scaffold results in robust formation of tendon‐like tissue [22]. Similarly, a collagen carrier combined with ASDCs showed they did not improve the biomechanical properties of the tendon‐to‐bone healing. However, the ADSCs group showed less inflammation, which may lead to a more elastic repair and less scarred healing in a rat model.
\n
\n
\n
2.3.2. Integra bilayer
\n
Integra® bilayer wound Matrix (LifeSciences Corp., Plainsboro, New Jersey) is a dermal acellular analog composed of bovine collagen type I crosslinked with glycosaminoglycans. Importantly, inclusion of WJ‐MSC into Integra induced significant up‐regulation of prototypical angiogenic and healing factors, stimulating pleiotropic aspects of neovascularization in experimental settings of angiogenesis, without altering the inflammatory response in the animals, thus demonstrating their potential benefit in therapeutic care of wounds and skin grafts [23]. Recently, Integra dermal matrix scaffold engineered with adult mesenchymal stem cells and platelet‐rich plasma was investigated in vitro and demonstrated promising preliminary results [24].
\n
\n
\n
\n
2.4. Synthetic biopolymer matrix
\n
Biopolymer matrix such as collagen, gelatin, hyaluronic acid, chitosan, silk, cellulose are the essential ECM components of human, animal, or plant cells. They have showed great promise for attachment, proliferation, and differentiation of stem cells and have been explored for tendon and skin regeneration.
\n
\n
2.4.1. Collagen
\n
Collagen monomer solution can be extracted from skin of fetal bovine calf in close herd. Collagen‐based biomaterial has been widely used for tendon/skin regeneration. For tendon application, it is highly desirable to prepare aligned collagen fiber scaffolds. Anisotropic collagen biomaterial can be prepared by directional freeze drying [25], electrospinning, or a novel process called electrochemical process. Electrochemically aligned collagen fiber and skin substrate have been coupled with stem cells for both tendon [26] and skin regeneration [27], respectively. Collagen carrier/gel [28] or collagen combined with stem cell accelerated the wound healing in healing‐impaired db/db mice [29].
\n
\n
\n
2.4.2. Pullulan‐collagen hydrogel
\n
A biomimetic pullulan‐collagen hydrogel was used to create a functional biomaterial‐based stem cell niche for the delivery of MSCs into wounds. Murine bone marrow‐derived MSCs were seeded into hydrogels and compared to MSCs grown in standard culture conditions. Hydrogels induced MSC secretion of angiogenic cytokines and expression of transcription factors associated with maintenance of pluripotency and self‐renewal. MSC‐seeded hydrogels showed significantly accelerated healing and a return of skin appendages [30].
\n
\n
\n
2.4.3. Gelatin
\n
Gelatin is denatured collagen. Human ADSCs laden gelatin microcryogels (GMs) were evaluated in vitro as a stem cell carrier. The cell phenotype markers, stemness genes, differentiation, secretion of growth factors, cell apoptosis, and cell memory were compared against cells without a carrier. The priming effects of GMs on upregulation of stemness genes and improved secretion of growth factors of hASCs were demonstrated.
\n
\n
\n
2.4.4. Hyaluronic acid (HA)
\n
Hyaluronic acid (HA) is a nonsulfated, linear polysaccharide with the repeating disaccharide, β‐1,4‐D‐glucuronic acid ‐ β‐1,3‐N‐acetyl‐D‐glucosamine (Mw: 100–8000 KDa). It is an ECM component. ADSCs combined with hyaluronic acid (ADSC‐HA) dermal filler were implanted in rats and compared with HA alone. It was demonstrated that ADSC‐HA has better filling effects than HA alone. A total of 70% of stem cells remain in the injection site after 3 months. These suggested stem cells have the potential to improve the esthetic effects and longevity of dermal fillers [31].
\n
\n
\n
2.4.5. Chitin/Chitosan
\n
Chitosan‐hyaluron membrane: Hsu et al. investigated adult ADSCs spheroids combined with a chitosan‐hyaluron membrane and showed biomaterial combined with stem cells promoted wound healing in a rat skin repair model [32]. Dense and porous chitosan‐xanthan membranes seeded with multipotent mesenchymal stromal cells were evaluated for the treatment of skin wounds. The membranes showed to be nonmutagenic and allowed efficient adhesion and proliferation of the mesenchymal stromal cells in vitro. In vivo assays performed with mesenchymal stromal cells grown on the surface of the dense membranes showed acceleration of wound healing in Wistar rats [33].
\n
\n
\n
2.4.6. Gelatin/PEG
\n
A thiol‐ene Michael‐type addition was utilized for rapid encapsulation of MSCs within a gelatin/PEG biomatrix according to Eq. (1). The MSCs/gelatin/PEG biomatrix was applied as a provisional dressing to full‐thickness wounds in Sprague‐Dawley rats. Biomatrix resulted in attenuated immune cell infiltration, lack of foreign giant cell (FBGC) formation, accelerated wound closure and re‐epithelialization, as well as enhanced neovascularization and granulation tissue formation by 7 days [34].
Electrospun nanofiberous scaffolds prepared from silk fibroin protein were seeded with bone marrow‐derived mesenchymal stem cells (MSCs) and epidermal stem cells (ESCs). The constructs were evaluated for wound re‐epithelization, collagen synthesis, as well as the skin appendages regeneration. It was shown that both the transplantation of MSCs and ESCs could significantly accelerate the skin re‐epithelization, stimulate the collagen synthesis. Furthermore, the regenerative features of MSCs and ESCs in activating the blood vessels and hair follicles formation, respectively, were suggested [35]. Combination of silk with collagen or poly(lactic-co-glycolic acid) (PLGA) [18] and stem cells were evaluated in a rabbit tendon defect model [36].
\n
\n
\n
2.4.8. Fibrin‐agarose
\n
A stroma skin substitute was first generated by using a mixture of human fibrin obtained from frozen human plasma and 0.1% agarose. An average of 250,000 cultured skin fibroblasts were added to 5 mL of the mixture immediately before inducing the polymerization of the artificial stroma on Transwell (Corning Enterprises, Corning, NY, http://www.corning.com) porous inserts. Once the stromas jellified, human umbilical cord Wharton’s jelly stem cells (HWJSCs) were seeded on top of the skin artificial stromas and cultured. It was demonstrated that this 3D bioactive scaffold can stratify and form epithelial cell‐like layers and well‐formed cell‐cell junctions [37]. The authors also demonstrated similar strategy can be used for regeneration of oral mucosa using human Wharton’s jelly stem cells (HWJSCs)‐seeded fibrin‐agarose‐mucosal fibroblasts.
\n
\n
\n
2.4.9. Sodium carboxymethylcellulose (CMC)
\n
Sodium CMC was evaluated as a substrate for ADSCs and implanted in adult male Wistar rats. CMC at 10 mg/mL associated with ADSCs increased the rate of cell proliferation of the granulation tissue and epithelium thickness when compared to untreated lesions (Sham). CMC is capable to allow the growth of ADSCs and is safe for this biological application up to the concentration of 20 mg/mL. These findings suggest that CMC is a promising biomaterial to be used in cell therapy [38].
\n\nTable 3\n summarizes common nondegradable polymer used as a biomaterial or as a modifier of ECM‐based biopolymer for skin and tendon tissue engineering applications. The incorporation of such polymer allows biopolymer (collagen, gelatin, HA) to be able to gelled at physiological condition (e.g., under UV/blue light, ambient temperature, or room temperature aqueous free radical initiator. Stem cells can be directly encapsulated inside the substrate during gel formation.
\n
Table 3.
Common synthetic, nondegradable polymer used as hydrogel or gel components.
\n
Table 4.
Common synthetic, degradable polymer used for tendon/skin regeneration applications.
\n
\n
2.5.1. Poly(NIPAM)‐based
\n
A biodegradable, multifunctional crosslinker and an n‐isopropylacrylamide (NIPAM)‐based, thermosensitive hydrogel was synthesized to carry BMSCs to treat diabetic skin ulcers. The crosslinker contains an arginylglycylaspartic acid(GRD)‐like motif that promotes cell attachment and differentiation of BMSCs. After hydrogel association with BMSCs treated the diabetic skin wound in mice, significantly greater wound contraction was observed in the hydrogel + BMSCs group. Histology and immunohistochemistry results confirmed that this treatment contributed to the rapid healing of diabetic skin wounds by promoting granulation tissue formation, angiogenesis, extracellular matrix (ECM) secretion, wound contraction, and re‐epithelialization. These results show that a hydrogel laden with BMSCs may be a promising therapeutic strategy for the management of diabetic ulcers [39].
The structure of common polyester is shown in \nTable 4\n. Stem cell‐coated polyester suture was evaluated for tendon applications in a rat model [40]. Electrospun PLGA fiber may be more suitable for tendon regeneration than film [41]. (PGA/PLA) fiber combined with ADSCs improve tendon in a rabbit tendon model [42]. Open cell PLGA seeded with stem cells produced more collagen type I [43]. Knited PLGA encapsulated with stem cell/alginate gel [44]. PGA sheet with MSCs were able to regenerate tendon‐bone insertions and the tendon in rabbit [45]. Electrospun polycaprolactone/gelatin (PCL/GT) membrane and human urine‐derived stem cells (USCs) were evaluated for skin wound healing in a rabbit model [46]. USCs‐PCL/GT‐treated wounds closed much faster, with increased re‐epithelialization, collagen formation, and angiogenesis. Moreover, USCs could secrete vascular endothelial growth factor(VEGF) and transforming growth factor (TGF)‐β1, and USC‐conditioned medium enhanced the migration, proliferation, and tube formation of endothelial cells. This data suggested that USCs in combination with PCL/GT significantly prompted the healing of full‐thickness skin wounds in rabbits. Similarly, electrospun poly (L‐lactide‐co‐ε‐caprolactone)/poloxamer (PLCL/P123) scaffolds combined with ADSCs enhanced skin wound healing in a rat model [47]. Chitosan‐crosslinked poly (3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) was used to load unrestricted somatic stem cells. The cell‐laden scaffold showed better results during the healing process of skin defects in rat models [48, 49].
\n
\n
\n
\n
3. Conclusion
\n
Biomaterials play an important role for attachment, survival, and function of stem cells. Many biomaterials are either used alone or as one component of the product for the regeneration of tendon/ligament/skin. Despite abundance of biomaterial developed, the optimal biomaterials that meet the structural, mechanical, functional requirement of tendon/ligament tissues to be regenerated remain a challenge. Novel biomaterial fabrication process, biomaterial design, and biomaterial synthesis toward tendon/ligament and skin regeneration are urgently needed.
\n
\n\n',keywords:"biomaterials, tendon, skin, regeneration",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/56104.pdf",chapterXML:"https://mts.intechopen.com/source/xml/56104.xml",downloadPdfUrl:"/chapter/pdf-download/56104",previewPdfUrl:"/chapter/pdf-preview/56104",totalDownloads:1219,totalViews:377,totalCrossrefCites:2,totalDimensionsCites:2,totalAltmetricsMentions:0,introChapter:null,impactScore:1,impactScorePercentile:69,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"November 7th 2016",dateReviewed:"May 11th 2017",datePrePublished:"December 20th 2017",datePublished:"February 14th 2018",dateFinished:"June 20th 2017",readingETA:"0",abstract:"Tendon/ligament injury or skin injuries due to diseases, trauma, and surgery are common. Timely functional repair and tissue regeneration is a key to improve the quality of life of the patient while reducing health care cost. Tendon/ligament/skin is also enriched in a common extracellular matrix (ECM), collagen I, III, and elastin. Tissue engineering and regenerative medicine, the combination of (stem) cells, growth factors, and biomaterial scaffolds, is an emergent field, which has attracted substantial attention over the years. Biomaterials are considered the foundation of regenerative medicine. A key to find a new solution to tendon/ligament/skin healing is to synthesize new functional biomaterials, which have better biomechanical properties, biodegradability, and cell supporting properties. This chapter will review existing FDA‐approved biomaterial‐based therapy, as well as those in development.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/56104",risUrl:"/chapter/ris/56104",book:{id:"5951",slug:"biomaterials-in-regenerative-medicine"},signatures:"Xingguo Cheng",authors:[{id:"200769",title:"Dr.",name:"Xingguo",middleName:null,surname:"Cheng",fullName:"Xingguo Cheng",slug:"xingguo-cheng",email:"xcheng@swri.org",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Southwest Research Institute",institutionURL:null,country:{name:"United States of America"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1. Research methods",level:"2"},{id:"sec_3",title:"2. Results",level:"1"},{id:"sec_3_2",title:"2.1. Biomaterial directly derived from patients",level:"2"},{id:"sec_3_3",title:"2.1.1. PRP",level:"3"},{id:"sec_4_3",title:"2.1.2. Fibrin",level:"3"},{id:"sec_5_3",title:"2.1.3. Amniotic membrane",level:"3"},{id:"sec_7_2",title:"2.2. FDA‐approved ECM grafts for tendon augmentation and skin regeneration",level:"2"},{id:"sec_8_2",title:"2.3. FDA‐approved biomaterial",level:"2"},{id:"sec_8_3",title:"2.3.1. Collagen sponge scaffold",level:"3"},{id:"sec_9_3",title:"2.3.2. Integra bilayer",level:"3"},{id:"sec_11_2",title:"2.4. Synthetic biopolymer matrix",level:"2"},{id:"sec_11_3",title:"2.4.1. Collagen",level:"3"},{id:"sec_12_3",title:"2.4.2. Pullulan‐collagen hydrogel",level:"3"},{id:"sec_13_3",title:"2.4.3. Gelatin",level:"3"},{id:"sec_14_3",title:"2.4.4. Hyaluronic acid (HA)",level:"3"},{id:"sec_15_3",title:"2.4.5. Chitin/Chitosan",level:"3"},{id:"sec_16_3",title:"2.4.6. Gelatin/PEG",level:"3"},{id:"sec_17_3",title:"2.4.7. Silk",level:"3"},{id:"sec_18_3",title:"2.4.8. Fibrin‐agarose",level:"3"},{id:"sec_19_3",title:"2.4.9. Sodium carboxymethylcellulose (CMC)",level:"3"},{id:"sec_21_2",title:"2.5. Synthetic nondegradable polymer‐based biomaterial",level:"2"},{id:"sec_21_3",title:"2.5.1. Poly(NIPAM)‐based",level:"3"},{id:"sec_23_2",title:"2.6. Polyester‐based degradable polymer biomaterial",level:"2"},{id:"sec_25",title:"3. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'\nUysal CA, et al. Adipose‐derived stem cells enhance primary tendon repair: Biomechanical and immunohistochemical evaluation. Journal of Plastic Reconstructive & Aesthetic Surgery. 2012:65(12):1712-1719\n'},{id:"B2",body:'\nXu K, et al. Platelet‐rich plasma activates tendon‐derived stem cells to promote regeneration of Achilles tendon rupture in rats. Journal of Tissue Engineering and Regenerative Medicine. 2017;11(4):1173-1184\n'},{id:"B3",body:'\nMartinello T, et al. Effects of in vivo applications of peripheral blood‐derived mesenchymal stromal cells (PB‐MSCs) and platlet‐rich plasma (PRP) on experimentally injured deep digital flexor tendons of sheep. Journal of Orthopaedic Research. 2013;31(2):306-314\n'},{id:"B4",body:'\nFalanga V, et al. Autologous bone marrow‐derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds. Tissue Engineering. 2007;13(6):1299-1312\n'},{id:"B5",body:'\nBadiavas EV, Falanga V. Treatment of chronic wounds with bone marrow‐derived cells. Archives of Dermatology. 2003;139(4):510-516\n'},{id:"B6",body:'\nChung E, et al. Fibrin‐based stem cell containing scaffold improves the dynamics of burn wound healing. Wound Repair and Regeneration. 2016;24(5):810-819\n'},{id:"B7",body:'\nSanchez‐Sanchez R, et al. Generation of two biological wound dressings as a potential delivery system of human adipose‐derived mesenchymal stem cells. Asaio Journal. 2015;61(6):718-725\n'},{id:"B8",body:'\nJi SZ, et al. An epidermal stem cells niche microenvironment created by engineered human amniotic membrane. Biomaterials. 2011;32(31):7801-7811\n'},{id:"B9",body:'\nYin Z, et al. The effect of decellularized matrices on human tendon stem/progenitor cell differentiation and tendon repair. Acta Biomaterialia. 2013;9(12):9317-9329\n'},{id:"B10",body:'\nBi Y, et al. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nature Medicine. 2007;13(10):1219-1227\n'},{id:"B11",body:'\nHuang SP, et al. Adipose‐derived stem cells seeded on acellular dermal matrix grafts enhance wound healing in a murine model of a full‐thickness defect. Annals of Plastic Surgery. 2012;69(6):656-662\n'},{id:"B12",body:'\nMartinello T, et al. Successful recellularization of human tendon scaffolds using adipose‐derived mesenchymal stem cells and collagen gel. Journal of Tissue Engineering and Regenerative Medicine. 2014;8(8):612-619\n'},{id:"B13",body:'\nOuyang HW, et al. Mesenchymal stem cell sheets revitalize nonviable dense grafts: Implications for repair of large‐bone and tendon defects. Transplantation. 2006;82(2):170-174\n'},{id:"B14",body:'\nProtzman NM, Stopyra GA, Hoffman JK. Biologically enhanced healing of the human rotator cuff: 8‐month postoperative histological evaluation. Orthopedics. 2013;36(1):38-41\n'},{id:"B15",body:'\nAltman AM, et al. Human adipose‐derived stem cells adhere to acellular dermal matrix. Aesthetic Plastic Surgery. 2008;32(4):698-699\n'},{id:"B16",body:'\nAltman AM, et al. Dermal matrix as a carrier for in vivo delivery of human adipose‐derived stem cells. Biomaterials. 2008;29(10):1431-1442\n'},{id:"B17",body:'\nGao Y, et al. Methodology of fibroblast and mesenchymal stem cell coating of surgical meshes: A pilot analysis. Journal of Biomedical Materials Research Part B Applied Biomaterials. 2014;102(4):797-805\n'},{id:"B18",body:'\nLam MT, et al. Effective delivery of stem cells using an extracellular matrix patch results in increased cell survival and proliferation and reduced scarring in skin wound healing. Tissue Engineering Part A. 2013;19(5-6):738-747\n'},{id:"B19",body:'\nLiu S, et al. Synergistic angiogenesis promoting effects of extracellular matrix scaffolds and adipose‐derived stem cells during wound repair. Tissue Engineering Part A. 2011;17(5-6):725-739\n'},{id:"B20",body:'\nMifune Y, et al. Tendon graft revitalization using adult anterior cruciate ligament (ACL)‐derived CD34+ cell sheets for ACL reconstruction. Biomaterials. 2013;34(22):5476-5487\n'},{id:"B21",body:'\nKato Y, et al. Allogeneic transplantation of an adipose‐derived stem cell sheet combined with artificial skin accelerates wound healing in a rat wound model of type 2 diabetes and obesity. Diabetes. 2015;64(8):2723-2734\n'},{id:"B22",body:'\nLee JY, et al. BMP‐12 treatment of adult mesenchymal stem cells in vitro augments tendon‐like tissue formation and defect repair in vivo. PLoS One. 2011;6(3):e17531\n'},{id:"B23",body:'\nEdwards SS, et al. Functional analysis reveals angiogenic potential of human mesenchymal stem cells from Wharton’s jelly in dermal regeneration. Angiogenesis. 2014;17(4):851-866\n'},{id:"B24",body:'\nFormigli L, et al. Dermal matrix scaffold engineered with adult mesenchymal stem cells and platelet‐rich plasma as a potential tool for tissue repair and regeneration. Journal of Tissue Engineering and Regenerative Medicine. 2012;6(2):125-134\n'},{id:"B25",body:'\nCaliari SR, Harley BA. Structural and biochemical modification of a collagen scaffold to selectively enhance MSC tenogenic, chondrogenic, and osteogenic differentiation. Advanced Healthcare Materials. 2014;3(7):1086-1096\n'},{id:"B26",body:'\nCheng XG, et al. Platelet‐derived growth‐factor‐releasing aligned collagen–nanoparticle fibers promote the proliferation and tenogenic differentiation of adipose‐derived stem cells. Acta Biomaterialia. 2014;10(3):1360-1369\n'},{id:"B27",body:'\nCheng X, et al. Preparation and in vitro evaluation of electrochemically‐aligned collagen matrix as a dermal substitute. MRS Advances. 2016;1(18):1295-1300\n'},{id:"B28",body:'\nValencia Mora M, et al. Application of adipose tissue‐derived stem cells in a rat rotator cuff repair model. Injury. 2014;45(Suppl 4):S22-27\n'},{id:"B29",body:'\nNambu M, et al. Accelerated wound healing in healing‐impaired db/db mice by autologous adipose tissue‐derived stromal cells combined with atelocollagen matrix. Annals of Plastic Surgery. 2009;62(3):317-321\n'},{id:"B30",body:'\nRustad KC, et al. Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold. Biomaterials. 2012;33(1):80-90\n'},{id:"B31",body:'\nNowacki M, et al. Filling effects, persistence, and safety of dermal fillers formulated with stem cells in an animal model. Aesthetic Surgery Journal. 2014;34(8):1261-1269\n'},{id:"B32",body:'\nHsu SH, Hsieh PS. Self‐assembled adult adipose‐derived stem cell spheroids combined with biomaterials promote wound healing in a rat skin repair model. Wound Repair and Regeneration. 2015;23(1):57-64\n'},{id:"B33",body:'\nBellini MZ, et al. Combining xanthan and chitosan membranes to multipotent mesenchymal stromal cells as bioactive dressings for dermo‐epidermal wounds. Journal of Biomaterials Applications. 2015;29(8):1155-1166\n'},{id:"B34",body:'\nXu K, et al. Thiol‐ene Michael‐type formation of gelatin/poly(ethylene glycol) biomatrices for three‐dimensional mesenchymal stromal/stem cell administration to cutaneous wounds. Acta Biomaterialia. 2013;9(11):8802-8814\n'},{id:"B35",body:'\nXie SY, et al. Adult stem cells seeded on electrospinning silk fibroin nanofiberous scaffold enhance wound repair and regeneration. Journal of Nanoscience and Nanotechnology. 2016;16(6):5498-5505\n'},{id:"B36",body:'\nZhang W, et al. Weft‐knitted silk‐poly(lactide‐co‐glycolide) mesh scaffold combined with collagen matrix and seeded with mesenchymal stem cells for rabbit Achilles tendon repair. Connective Tissue Research. 2015;56(1):25-34\n'},{id:"B37",body:'\nGarzon I, et al. Wharton’s jelly stem cells: a novel cell source for oral mucosa and skin epithelia regeneration. Stem Cells Translational Medicine. 2013;2(8):625-632\n'},{id:"B38",body:'\nRodrigues C, et al. New therapy of skin repair combining adipose‐derived mesenchymal stem cells with sodium carboxymethylcellulose scaffold in a pre‐clinical rat model. PLoS One. 2014;9(5):e96241\n'},{id:"B39",body:'\nChen S, et al. Mesenchymal stem cell‐laden anti‐inflammatory hydrogel enhances diabetic wound healing. Scientific Reports. 2015;5:18104\n'},{id:"B40",body:'\nAdams Jr SB, et al. Stem cell‐bearing suture improves Achilles tendon healing in a rat model. Foot & Ankle International. 2014;35(3):293-299\n'},{id:"B41",body:'\nJames R, et al. Tendon tissue engineering: Adipose‐derived stem cell and GDF‐5 mediated regeneration using electrospun matrix systems. Biomedical Materials. 2011;6(2):025011\n'},{id:"B42",body:'\nDeng D, et al. Repair of Achilles tendon defect with autologous ASCs engineered tendon in a rabbit model. Biomaterials. 2014;35(31):8801-8809\n'},{id:"B43",body:'\nKim YS, et al. Survivorship of implanted bone marrow‐derived mesenchymal stem cells in acute rotator cuff tear. Journal of Shoulder and Elbow Surgery. 2013;22(8):1037-1045\n'},{id:"B44",body:'\nVaquette C, et al. A poly(lactic‐co‐glycolic acid) knitted scaffold for tendon tissue engineering: An in vitro and in vivo study. Journal of Biomaterials Science Polymer Edition. 2010;21(13):1737-1760\n'},{id:"B45",body:'\nYokoya S, et al. Rotator cuff regeneration using a bioabsorbable material with bone marrow‐derived mesenchymal stem cells in a rabbit model. The American Journal of Sports Medicine. 2012;40(6):1259-1268\n'},{id:"B46",body:'\nFu Y, et al. Human urine‐derived stem cells in combination with polycaprolactone/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis. Journal of Translational Medicine. 2014;12:274\n'},{id:"B47",body:'\nGu J, et al. Adiposed‐derived stem cells seeded on PLCL/P123 eletrospun nanofibrous scaffold enhance wound healing. Biomedical Materials. 2014;9(3):035012\n'},{id:"B48",body:'\nBiazar E, Keshel SH. The healing effect of stem cells loaded in nanofibrous scaffolds on full thickness skin defects. Journal of Biomedical Nanotechnology. 2013;9(9):1471-1482\n'},{id:"B49",body:'\nZeinali R, et al. Regeneration of full‐thickness skin defects using umbilical cord blood stem cells loaded into modified porous scaffolds. ASAIO Journal. 2014;60(1):106-114\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Xingguo Cheng",address:"xcheng@swri.org",affiliation:'
Southwest Research Institute, San Antonio, TX, USA
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1. Introduction
The world\'s population of 7.6 billion people is still growing and is expected to reach 8.3 billion by 2025 and almost 10 billion by 2050 [1]. Concomitantly, the Earth’s resources are depleting. According to the different scenarios, global food demand is expected to increase by 40–68% by 2050 [2]. Among food resources, plants are of particular interests, as the global production of plant-based products is constantly increasing while producing significant waste. In this context, recycling or revalorizing these by-products is a priority [1].
The main objectives of using plant by-products are to revalorize wastes, reduce pollution, and limit resource depletion. Fermentation is one of the least polluting methods. Plant by-products fermentation contributes to sustainable development; in fact, this type of valorization is part of some objectives of the United Nations 2030 Agenda, notably the third objective: good health and well-being and the twelfth objective: responsible consumption and production. The consumption of fermented plant by-products therefore allows responsible consumption. The fermentation of plant by-product leads to bioactivities related to human health such as antioxidant, anti-inflammatory, or antimicrobial activities that contribute to good health and well-being [3]. Plant-based foods are sources of many bioactive compounds such as fibers, vitamins, minerals, or phenolic compounds. These nutrients are necessary for the survival and growth of organisms [4]. In many countries, the health benefits of certain plant and their traditional use have been recognized for decades [5]. Since industries have been exploiting plant-based foods, many agro-industrial by-products that still contain valuable compounds have been generated. Many companies are now seeking to recycle waste from their fruit and vegetable activities in order to address environmental and economic issues. For example, cereal waste reached about 40,000–45,000 tons per year in Europe [6]. The by-products are mainly used for livestock feed or methanisation but have great potential to generate food or dietary supplements for human use [6, 7]. Another example concerns the waste from the citrus industry, which amounts to 50 million tons per year and is the most important waste from fruits exploitation. The management of by-products represents a real food waste problem and raises major issues [8]. Therefore, in recent years, there has been a growing interest in the valorization of plant by-products.
In China, for 9000 years, humans have empirically exploited the fermentation process for numerous applications [9]. Studied since the nineteenth century, lactic acid fermentation has been an essential process for food processing and preservation for many millennia [10]. Humans took advantage of it for their food, notably by developing bread, beer, wine, cheese, or vinegar. Subsequently, fermentation with lactic acid bacteria has been largely studied to improve the nutritional and functional properties of plants. Due to their richness in nutrients, water, and natural ferments, plants such as fruits and vegetables represent an optimal substrate for Lactobacillus [11]. Lactic acid bacteria constitute a diverse group of Gram-positive, catalase-negative bacteria producing lactic acid as the main end product. Many food products fermented by lactic acid bacteria are obtained with organisms belonging to the genus Lactobacillus[12]. With more than 200 species of Lactobacillus bacteria [11], this genus is certainly the main and most diverse group of lactic acid bacteria. A study published in 2020 re-evaluated the genetic relatedness and phylogeny of Lactobacillus species. Based on a polyphasic approach such as whole-genome comparison, core genome phylogeny, physiological criteria, and ecology of the organisms, the genus Lactobacillus was reclassified into 25 genera (2 preexisting genus and 23 new genera). This work showed the great and extensive diversity of the Lactobacillaceae family [13]. Lactobacillus species are commonly used in fermented food. Depending on the species, their enzymatic activities including amylase, lactate dehydrogenase, peptidase, proteinase, α- and β-glucosidases, decarboxylase, lactate dehydrogenase, peptidase, phenolic acid decarboxylase, phenol reductase, proteinase or tannase are very useful in food fermentation [14]. These enzymes can degrade the plant cell wall matrix, resulting in the release of many bioactive compounds, which may or may not be modified structurally by the action of other enzymes in the bacteria.
Today, several ecological and economic issues are at the heart of lactic fermentation research. The optimization of yield, cost, and energy consumption and the valorization of plant-derived products represent challenges for the industry [15]. To meet this demand, the use of new substrates and the genetic engineering of fermentation strains are being studied as potential solutions [11]. Moreover, it is now known that lactic fermentation increases the content of bioactive compounds. Indeed, this fermentation process is well known to strengthen the immune and antioxidant (AO) effect of medicinal plants by increasing the bioavailability of active compounds, but also through the production (or the bioconversion) of plant metabolites into new bioactive molecules [16]. To increase the bioactivities and organoleptic characteristics of fermented products, Lactobacillus converts metabolizable molecules with their enzymes, in particular L. plantarum, which is one of the most used Lactobacillus as a fermentation starter. This degradation increases the bioavailability of molecules and improves their absorption [17]. A fermentation starter is usually a consortium of bacteria that helps the fermentation process to start. Today, the use of starter cultures in food fermentation is one of the necessary ingredients for good production. In addition, LAB used as starter in the food industry provide safe product with good nutritional and organoleptic qualities. LAB are used as starter for many products, including fruit, vegetables, and cereal [18]. As illustrated in Figure 1, the production of biomolecules by lactic fermentation of plant by-products can induce other bioactivities. This chapter refers to antioxidant (AO), anti-inflammatory (AI), antimicrobial, prebiotic activities, and others. These can be used in human food and beverage, livestock feeding, or biotechnology mainly to produce lactic acid. Those activities and applications will be detailed in this chapter.
Figure 1.
Summary of the biomolecules, bioactivities generated by the fermentation by Lactobacillus strains of plant products or by-products, and their application domains.
2. Bioactivities resulting from the fermentation of plant products or by-products by Lactobacillus genera
2.1 Antioxidant activity
Many Lactobacillus enzymes can generate compounds with strong AO activity from plant by-products. For example, β-galactosidase releases isoflavone and oleuropein aglycone while tannases generate propylgallate [16].
Glycosylated polyphenols such as tannins, lignans, isoflavones, flavonols, and anthocyanins are widespread in plant products. Absorption in the intestine depends mainly on their degree of glycosylation. Some strains of Lactobacillus, such as L. plantarum, possess glycosidases that are crucial for the absorption of glycosylated polyphenols and consequently for the resulting AO activity [19]. In most cases, the AO activity is studied with classical biochemical antioxidant assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2\'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), hydrolxyl or alkyl radical scavenging activities, the ferric-reducing antioxidant power (FRAP), superoxide dismutase (SOD) -like activity, β-carotene bleaching, and oxygen radical absorbance capacity (ORAC). In addition to in vitro biochemical tests, other studies have investigated the antioxidant capacity of fermented products with in vitro cell-based assays. Reference [16] demonstrated that the fermentation of L. plantarum increased the AO properties of a kiwi extract. They correlated this result with increased amounts of protocatechic and chlorogenic acid in the fermented products, which were less represented in the starting extract [20]. Gallic acid production was also observed with the fermentation of red chicory leaves by L. plantarum et L. hilgardi thanks to tannases [21]. In addition, co-fermentation by L. gassieri and Bifidobacterium animalis resulted in the release of caffeic acid and conjugated chlorogenic acid after fermentation of sunflower seeds through the action of cinnamoyl esterase. Tannins are also the product of biomass fermentation by Lactobacillus. Tannases hydrolyze the ester bond, and gallate decarboxylase converts gallic acid to pyrogallol; thus, Lactobacillus generates gallic acid, glucose, and pyrogallol [22].
Several studies have illustrated the fermentation of plants such as Indian chilli pepper, grape pomace, dandelion beverage, and cereal-based plant beverages by Lactobacillus spp., resulting in polyphenol compounds (caffeic acid, succinate, pyruvate, pyroglutamate) with AO capacity [23, 24, 25]. In [26], they evidenced that rice bran and wheat bran fermented with L. plantarum possessed AO capacity through their hydroxyl and oxygen radical scavenging activities. Furthermore, the purified fractions exerted reactive oxygen species (ROS) scavenging activity in HUVEC cells and decreased the senescence of the cultured cells, also conferring an antiaging activity to the fermented fractions. These activities were attributed to the acids and ketones [26]. Co-cultivation of L. johnsonii and Bacillus coagulans was undertaken in [27] to produce a soybean meal with improved AO properties. Interestingly, the co-cultivation resulted in a significant increase in total phenolic content [27]. Fruits are also an excellent matrix for fermentation due to their high content of dietary fiber, sugars, vitamins, minerals, and phenols. Furthermore, lactic fermentation preserves and improves food safety, nutritional value and preserves the organoleptic quality. In particular, when plants are fermented by Lactobacillus endophyte, it preserves of color, firmness, AO activity, growth of fermentation starters and inhibits pathogens in media. Many studies have been conducted on the lactic fermentation of polyphenol-rich berries and red fruits. L. casei has been studied for the fermentation of blueberry pulp [28]. In another example studied in [29], mulberry juice fermented in coculture by three different strains (L. plantarum, L. acidophilus, and L. paracasei) showed a higher AO capacity [29].
In reference [30], they investigated the fermentation of cherry silverberry fruits (Elaeagnus multiflora Thunb.) fermented with pure cultures of L. plantarum KCTC 33131 and L. casei KCTC 13086 alone or in mixed culture. In reference [31], they studied the fermentation by L. plantarum FNC 0027 of Jamaican cherry (Muntingia calabura Linn.), which induces the production of phenolic compounds and the inhibition of diabetic-related enzymes (α-glucosidase, α-amylase, and amyloglucosidase). They demonstrated the production of gallic acid, 5,7 dihydroxyflavone, and dihydrokaempferol [31].
The valorization of argan press cake was also carried out by lactic acid fermentation using a specifically isolated strain of L. plantarum Argan-L1. Argan press cake is a waste of oil production containing polyphenols and saponins. The authors demonstrated that sucrose from argan press cake was easily converted to lactic acid during the fermentation process. Furthermore, the fermented extract presented an increased AO capacity, but the total phenolic compound was slightly decreased [32].
L. plantarum KCCM 11613P isolated from Kimchi allowed the production of ginsenosides after fermentation of Korean red ginseng (Panax ginseng)[33]. In reference [34], it was shown that fermented soymilk products exhibited improved AO capacity associated with increased isoflavone aglycone content. In addition, fermented extracts inhibited the DNA oxidation induced by the Fenton reagent [34]. All these studies show the interest in using Lactobacillus to increase the antioxidant properties of fermented products. Moreover, this antioxidant activity is often associated with the anti-inflammatory activity of certain extracts. Fermentation of other plant matrices can induce antioxidant activity of the products, as shown in Table 1.
Vegetables, fruits, and plants (tomato, cucumber, pear, apple, mandarin, parsley, carrot, celery, onion, burdock, kale, spinach, aloe vera, civet, grape, jujube, cabbage, and perilla) fermented by L. plantarum offer interesting AI molecules [51]. These molecules include organic acids (OAs) such as lactic acid, 3-phennyl-lactate, indole-3-lactate, β-hydroxybutyrate, gamma-aminobutyric acid (GABA), and glycerol. When investigating the AI (and AO) capacity of these compounds, the parameters studied werethe levels of nitric oxide (NO), IL-6 (interleukins) and tumor-necrosis factor-alpha (TNF-alpha), and the DPPH test on RAW cells [52]. Another study showed the AI properties of a fermented plant extract (Artemisia capillaris) in RAW 264.7 cells, which stimulated NO and IL-10 secretion without cytotoxic effects [53]. Thus, the fermentation of Aronia melanocarpa extract by L. plantarum was investigated to produce GABA, polyphenol, and flavonoid compounds. The fermented extract was shown to exert AI effects inhibiting the production of proinflammatory cytokines in RAW 264.7 cells and modulating the immune response in mice [54]. Furthermore, several molecules derived from the fermentation of red fruit juices have been studied for their AI effects. For example, anthocyanins from these products are thought to produce the TNF-alpha and proinflammatory cytokines [23].
Fermented Asian products were highly investigated for their AI properties. For example, a specific strain of L. plantarum is involved in the fermentation of the traditional korean fermented vegetable food, the kimchi. It has been shown to secrete exopolysaccharides able to protect against rotavirus-induced diarrhea [55]. Turmeric, another plant originating from Asia, has been also extensively studied for its AI properties and particularly after fermentation. The development of turmeric extracts with potential health applications, particularly for inflammation, is increased.
The production of curcuminoid molecules, such as curcumin, has been enhanced by fermentation of turmeric (Curcuma longa) by L. johnsonii. The turmeric extracts showed AI and antiallergic effects in atopic dermatitis mice and induced a decrease in serum immunoglobulin E and proinflammatory cytokines in lipopolysaccharide-induced inflammation (LPS) [56]. Supplementation of turmeric extract fermented by L. rhamnosus (GG-ATCC 53103) and Bifidobacterium animalis (BB12) strains maintained bacterial growth of the gut microbiota in case of inflammation.
It also reduced the inflammatory state by limiting the production of proinflammatory cytokines IL-8 [57]. Another study showed that the fermentation of turmeric by L. fermentum has increased the curcumin yield by 9.76%. The AI activity was demonstrated in RAW 264.7 cells by modifying the nitrite level, the expression of TNF-alpha and TLR-4, and the activation of the JNK pathway. These phenolic compounds also showed a protective effect against the activation of TLR-4 receptor cascade, TNF-alpha, and nitric oxide production. In addition, the extract limited the proinflammatory response and low-grade oxidative stress induced by LPS [58].
2.3 Antimicrobial activity
The molecules produced during the fermentation of plant biomasses by Lactobacillus can also exhibit antimicrobial activities. The production of antimicrobial molecules by Lactobacillus has already been described, including lactobrevin and lactobacillin [59]. For example, in [60], an interesting concept of valorization of okara by solid-state fermentation was presented with a coculture of the yeast Yarrowia lipolytica and Lactobacullis casei. Okara is an oleaginous by-product of plant milk production. The authors used fermentation to generate molecules with antimicrobial activity (up to 33% reduction of Bacillus subtilis development and a modest effect on Aspergillus niger one)[60].
In reference [61], a metabolic study on Allium tuberosum to produce a food additive with antimicrobial activity against poultry pathogens was conducted. Endophytic Lactobacillus have been isolated from Chinese chives. Among those Lactobacillus strains, L. plantarum can produce flavonols with antimicrobial activity [61]. In [62], fermentation of quinoa by the strain L. plantarum CDL 778 leads to a higher production of antifungal compounds. It was also observed that during the fermentation of sweet lemon juice (Citrus limetta), the antimicrobial activity against Escherichia coli and Salmonella Typhimurium was increased. These activities were correlated with the increase in lactic acid content and the decrease of citric acid, total phenolic compounds, and sugar content [63]. Moreover, fermentation of the red sorghum cereal allows the conversion of flavanones into eriodyctiol and naringenin, which have shown an interesting antimicrobial activity [22].
2.4 Prebiotic activity
Several studies have shown that fermented fruits and vegetables have prebiotic effects. The compounds produced by the fermentation of plants induce a modification of the intestinal microbiota. These fermented extracts offer great prospects. Studies highlighted their health potential for humans but also animals. Indeed, two fermented extracts obtained from algae and chicory, plantain, alfalfa, and broad leaf dock presented prebiotic and AO effects. This study was conducted on weaned lambs, and the results showed improved resistance to infection and survival for both extracts. Similar studies have shown the same effects for thyme and rosemary [64]. In reference [65], the prebiotic potential was determined, and the AI effect of chicory root and pulp compared with inulin, as a positive control, on the intestinal barrier on IPEC-J2 cells. These tests were performed with five fermented by-products (chicory roots, chicory and citrus pulp, rye bran, and soybean bark) by different Lactobacillus spp. An increase of Lactobacillus spp. was observed for all substrates except for chicory roots. The latter was very fermentable and produced a butyrate ratio similar to that of inulin, while chicory pulp had a higher ratio than inulin. For acetate, chicory and citrus pulp and soybean bark had a higher ratio than inulin. These short-chain fatty acids (SCFAs) derived from dietary fiber fermentation contribute to maintain intestinal health. Rye bran caused a significant stimulation of the growth of Bifidobacterium spp. Rye bran and soybean bark have a positive effect on the gut microbiota. Fermented chicory roots and pulp promote the upregulation of tiny junction genes and maintain the integrity of the gut barrier. Finally, fermented chicory pulp inhibits proinflammatory cytokines such as TNF-alpha and triggers the metabolic pathway that inhibits inflammatory cytokine production [65].
2.5 Other bioactivities related to medicine
Many bioactivities could result from the lactic fermentation of plant by-products. In reference [66], they associated the AO activity with potential hypoglycemic effects of Diospyros lotus fruit fermented by L. plantarum and Microbacterium flavum. They observed an inhibition of the α-glucosidase activity in vitro. In addition, the authors showed that catechinic, tannic, and ellagic acid levels were enhanced during fermentation [66]. Similarly, several studies were interested in the capacity of Lactobacillus fermented products to exert a positive effect in the prevention of obesity and associated metabolic diseases. In [67], cabbage-apple juice fermented by L. plantarum exerted anti-obesity and hypolipidemic effects in vivo in high-fat diet–fed rats was highlighted [67].
Moreover, soy products fermented with Lactobacillus spp. have interesting biomolecular contents and present antitumoral effects. Indeed, these fermented soybean extracts could inhibit, in vitro, the growth of several cancerous cell models: fibrosarcoma and adenocarcinoma of the breast. It also reduces the risk of breast cancer, significantly influencing survival, apoptosis, and tumor inhibition rates in mice. Clinical studies were also conducted to investigate the effects of fermented soybean extract on chemotherapy-induced immunosuppression. The results showed that the populations of immune cells with activity against tumor cells, the natural killer cells, are significantly increased [23]. Using cell-based experiments, other work has investigated putative health effects associated with AO activity. Indeed, the authors showed promising antiproliferative and apoptotic effects of the extracts on the HeLa cancer cell line. In another study, the authors showed that blueberries fermented by L. plantarum exhibited anticancer activities. Their results suggest that polyphenols, in high concentrations in blueberries, were metabolized during fermentation into active phenols such as catechol [68].
3. Applications
3.1 Food products
Product of the lactic fermentation, bread has been, for a longtime, an important foodstuff of the diet of many cultures. The bread fermentation process has often been optimized and revisited to better meet consumer needs or to address economic and social issues. The fermentation of wheat leaven by L. plantarum allows the conversion of ferulic acid into vinyl guaiacol, ethyl guaiacol, and dihydro ferulic acid. This conversion improves the quality of the final bread product [22].
Corn flour is another example of a bread raw material, and its application in bakery illustrates the potential of lactic fermentation. In addition to the different ingredients of wheat bread, maize meal improves the nutritional profile after being fermented with L. plantarum T6B10 and Weissella onfuse BAN8. Indeed, an increase in amino acid (AA) and protein content, AO activity, and inhibition of lipases and phytic acid were observed. This leads to an increase in dietary fiber, digestibility, and improves the texture, taste, and nutritional value of bread [69]. The same outcome was observed with the fermentation of brans from hullless barley, emmer and pigmented wheat varieties with the same Lactobacillus under the same conditions [70]. Another study highlighted the replacement of wheat flour substitute for breadmaking, a sourdough obtained from fermented djulis (Chenopodium formosanum) by L. casei. The bread produced contained higher levels of total phenolic and flavonoid compounds and increased hardness and chewiness compared with conventional bread. The addition of djulis sourdough also extended the shelf life by approximately 2 days [71].
A process to valorize semolina pasta with hemp flour, chickpea grains, and milling by-products by fermenting them with L. plantarum and L. rossiae has been proposed [72]. However, it is necessary to note that enzymatic pretreatment of the substrates must be carried out beforehand. This could affect the economic viability of the process. At a laboratory scale, they obtained extensive protein degradation and consequently digestibility, a 50% reduction in tannin concentration and also in phytic acid concentration [72]. L. plantarum, which has high proteolytic activities, was used for the fermentation of quinoa instead of wheat. Quinoa is an interesting cereal for celiac patients because it is gluten-free. The study revealed that quinoa is more easily fermented by lactic acid bacteria than wheat. These high proteolytic activities of the strain were evidenced by the increase of the total peptides and free AA contents from quinoa slurries compared with wheat slurries [62]. In reference [70], the potential use of oat extract from cereal processing with high protein content as an alternative to yoghurt was questioned. Fermentation of this by-product with L. delbrüchii subsp. Bulgaricus and Streptococcus themophilus followed by starch gelatinization by heating generated two kinds of gels with interesting rheological and organoleptic properties. Authors placed their studies in the context of plant-based products substituting dairy ones for health and environmental reasons. They discussed the consumer acceptance of these products but claimed that sensory descriptors such as soft, sweet, and smooth are highlighted by the sensory panel [73]. Another example of food products fermentation value is the fermentation of olive by L. plantarum. Kachouri et al. have shown that the phenolic content of olive oil increases after fermentation by this strain [74]. Other studies have shown that the fermentation of the common Spanish table olive improves preservation and the taste. Indeed, L. plantarum ferments olive brine, leading to a reduction in the oleuropein content of the olives [75, 76, 77, 78, 79]. In addition, wastewater from olive production, which is another olive coproduct, has been exploited in [80]. When fermented by L. plantarum, the content of phenolic compounds becomes more interesting. The antioxidant activity was tested by DPPH and ABTS assay. This coproduct has a 50% higher antioxidant activity after fermentation by L. plantarum [80].
In order to innovate in the food market, research is being carried out into the development of plant-based drinks rich in active compounds and with health benefits for consumers. Functional plant beverages fermented with Lactobacillus are being widely studied. Aqueous extracts of plants such as soy, pea, coconut, or rice represent alternatives to nondairy milk. Lactic acid fermentation of these beverages could improve the protein content, solubility, and availability of AA. Some strains of Lactobacillus are also responsible for the biosynthesis of vitamins during fermentation (vitamin K, vitamin B). Anti-nutritional compounds such as phytates are hydrolyzed during fermentation by some phytase-producing strains, which improves the digestibility and mineral content of the final product [81]. However, optimizing flavors and nutritional quality remains a challenge today because the latter are often criticized for their low nutritional quality and bland taste caused by their short shelf life. A color change has been observed by Do and Fan in fruit or carrot juices fermented by Lactobacillus strains, indicating that carotenoids are modified to cis-carotenoid isomers responsible for color change during fermentation by Lactobacillus [82]. Rheological studies have also been performed. Indeed, in [83], the effects of different Lactobacillus species on volatile and nonvolatile flavor compounds in juices fermentation were studied. The main objective of this research was to identify the marker metabolites generated by different species of Lactobacillus strains, which contribute to the flavor and reveal the roles of various Lactobacillus species in the formation of flavor compounds. The main markers were 2.3 butanedione, hexenal, acetic acid, formic acid as volatile compounds and lactic acid, malic acid, citric acid as nonvolatile compounds [83].
In another application for the beverage sector, one of the main ideas is to provide fermented products with prebiotic effects from a different matrix of vegetable juice as raw material. Consumers’ demand for non-dairy prebiotic foods is constantly increasing due to drawbacks related to dairy foods such as allergy, lactose intolerance, as well as lifestyle change or religious beliefs. In this context, reference [71] presents a development of a functional drink based on soy and quinoa (Chenopodium quinoa Willd) obtained by fermentation by Lactobacillus casei LC-1. This drink presents a prebiotic effect stimulating the gut microbiota and reducing the following bacterial populations: Clostridium spp, Bacteroides spp, Enterobacteria, and Enterococcus spp [84]. Cabbage juice and fresh cabbage, fermented by Lactobacillus, are also being studied for the development of probiotic products. When mixed with other vegetables (carrots, onion, cucumber), white and red cabbage fermented with L. plantarum, L. casei , L. acidophilus, or L. delbrueckii shows a good fermentation profile and potential as a functional probiotic drink as demonstrated by Hyunah et al. [85, 86, 87, 88]. Dunkley and Hekmat evaluated the sensory properties and worked to assess the growth and viability of L. rhamnosus GR-1 in carrot juice, carrot apple juice, carrot orange juice, and carrot beetroot juice over 72 h of fermentation and 30 days of refrigerated storage at 4°C. The conclusion was that carrot, carrot apple, carrot orange, and carrot beetroot juice fermented with L. rhamnosus GR-1 proved to be a satisfactory alternative to dairy-based prebiotic products. All juices achieved viable counts above the minimum counts required to be classified as prebiotic. The results of sensory evaluation also indicated a market potential for prebiotic vegetable juice. The development of prebiotic vegetable juice using L. rhamnosus GR-1 as a probiotic agent will provide consumers a viable non-dairy alternative that can provide many health benefits [89]. Co- or triculture can be used to enhance activities. Bergamot juice was fermented by three Lactobacillus (L. plantarum 107 subsp plantarum PTCC 1896, L. plantarum AF1, L. plantarum LP3) in triculture. This combination resulted in a higher AO activity. Bergamot juice fermented could also be used as a functional drink [90].
Other by-products are recycled, especially in the brewery sector. One study aimed to produce a polyphenol-rich beverage from brewers’ spent grain. Fermentation by L. plantarum ATCC 8014 was realized, followed by tests on phenolic compound content and AO activity. Phenol content and AO have increased during fermentation. The beverage was more concentrated in phenolic compounds than before fermentation, and its bioactive compounds were more stable [91]. More recently, coffee cherry pulp has been used in infusion to obtain an AO drink called cascara. To improve the AO activity of this beverage, it was fermented by endophytic L. casei [92]. A turmeric-based functional drink was also obtained by co-fermentation with Enterococcus faecium, Lactococcus lactis subsp. Lacti, and L. plantarum. The AO capacity was measured by titration of total phenolic compounds, and the prebiotic effect was also highlighted by in vitro and in vivo tests.
Kombucha is a sweet infusion of green tea leaves usually fermented with Kombu, a fungus. One study shows that replacing Kombu with L. casei and L. plantarum, which are derived from kefir, enhances the production of glucuronic acid, leading to greater antimicrobial and antioxidant activities [93]. Another study showed that a mixture of LAB from kefir and kombucha (L. casei, L. plantarum, L. acidophilus. L. casei, and L. plantarum) increases the glucuronic acid concentration, antimicrobial and antioxidant activities and allows the use of Kombucha as a health drink [94]. Hou et al. demonstrated the link between antimicrobial activities of kombucha with polyphenols and LAB, especially against Escherichia coli, Salmonella tiphy, Vibrio cholerae, and Shigella dysenteriae [95]. Green tea used in Kombucha may have activity when fermented by L. plantarum. Indeed, fermented extract derived from Camellia sinensis is able to mitigate ethanol-induced liver damage. In vitro and in vivo tests on hepatic cells (HepG2,) and murin model exposed to fermented green tea extract show after exposure of ethanol a better viability and an increase of hepatic alcohol dehydrogenase [96].
3.2 Livestock feeding
The products of plant fermentation by Lactobacillus strains can be used in many fields ranging from livestock feeding, such as ruminant by decreasing gas production [97]. Lactobacillus strains can also be used for silage preparation. Silages are grass or other green fodder that is compacted and stored under airtight conditions, typically in a silo, for use as livestock feeding in the winter. Many studies focus on using Lactobacillus strains to improve the quality of the silage. In reference [98], the effect of L. brevis and L. parafarraginis used as inoculants and the microbial communities of corn stover silage were studied. After 20 days, the two Lactobacillus strains were predominant, and a reduction in lactic acid content coupled with an increase in acetic acid and 1.2-propanediol contents was observed. An improvement in the silage quality and reproducibility of the ensiling process were observed [98]. Recently in [99], the effect of L. plantarum addition on the nutritive value of dwarf elephant grass (Pennisetum purpureum cv Mott) silage was presented. The aim was to examine the effects of different L. plantarum addition on the physical quality, pH, and nutritional value (dry matter, organic matter, crude protein, crude fiber). After incubation, a good silage quality (fresh and acidic odor, good texture, and no fungi) and a pH around 4 were observed. L. plantarum addition accelerates ensilage fermentation [99]. In [100], an increase in silage quality by adding waste molasses to L. plantarum MTD1 was observed. In the same context, the addition of cellulase was studied to evaluate the effects on the chemical composition, bacterial communities, stability of mixed silage made with high-moisture amaranth and rice straw fermented by L. plantarum.
Cellulases increased the abundance of Lactobacillus bacteria and reduced the abundance of other lactic acid bacteria. It decreased pH, acetic acid content, ammonia nitrogen content and increased lactic acid concentration after 7 days of ensiling [101]. In conclusion, silage treated with both Lactobacillus bacteria and cellulase showed the best silage quality. Optimizing the digestibility of feeds and thus increasing their nutritional value are a challenge for the livestock feeding industry. In another study, the fermentation product of a mixture of ginger and turmeric extract by Lactobacillus spp. was supplemented to chickens. Biological analyses of AO enzymes and analysis of gut microbiota and lymphoid organs showed a prebiotic effect, an AO effect, and an improvement in resistance to bacterial infections [102].
3.3 Lactic acid production from plant biomass
The use of low-cost by-products is of primary interest as it reduces production costs compared with the use of complex culture media made with pure and refined products. Consequently, many by-products have been tested in the last few years, in association with screening of the best microbial strains, the best fermentation process, and the best conditions to make them work together [103]. Lactic acid is one of the most widely used organic acids for a long time in various industries, such as food, cosmetics, pharmaceutical, and textile industries, and flavor, conservation, AO, and antimicrobial activity [104]. In the last decade, it has also become an essential platform molecule in the biomaterials sector to produce poly-lactic acid (PLA), a bio-based polymer. This new interest has led to an explosion in worldwide demand. One of the characteristics of polylactic acid is its thermal resistance, a critical parameter for manufacturing thermoformed materials (packaging, film, etc.). Lactobacillus have been traditionally used for lactic acid production [105, 106]. When using large-scale fermentation bioprocesses, the biomass feedstock must be carefully selected as it accounts for almost half of the biopolymers production costs [105]. To address this production cost issue, scientists and industrials have been focused on lignocellulosic biomass as a fermentation substrate for lactic acid production. Nevertheless, in order to be easily usable, saccharification pretreatments are needed to break down the cellulose into fermentable carbohydrates. Moreover, Lactobacillus are classified as either homofermentative or heterofermentative. L. delbrueckii is a homofermentative strain commonly used for the production of lactic acid [107]. Homofermentative strains of Lactobacillus cannot use pentose carbohydrates from hemicellulose, but heterofermentative ones, such as L. brevis, can use these carbohydrates through the phosphoketolase pathway [106].
In reference [105], the fermentation of 11 different carbohydrates from seaweed or plant biomass as a carbon source to produce L-lactic acid with seven different Lactobacillus species was investigated. A comparative analysis of the expected yield of lactic acid production revealed that seaweeds provided comparable production rates to lignocellulosic biomasses [105]. In another study, beet molasse was used to produce lactic acid using L. delbrueckii IFO 3202 during batch and continuous fermentation, dilution rate of 0.5 h−1 was determined to be the best one and allowed to reach a maximum productivity of 11 g L−1 h−1. Authors have demonstrated the importance of medium supplementation by yeast extract, as Lactobacilli are tedious microorganisms that require many substrates and substances to grow [108]. Nevertheless, it is estimated that the addition of yeast extract can contribute up to 30% of the cost of producing lactic acid [109]. Zhang & Vadlani studied the production of D-lactic acid by a homofermentative strain, L. delbrueckii ATCC 9649, through a sequential hydrolysis and fermentation process (SHF) and a simultaneous saccharification and fermentation process (SSF). In this work, first, the saccharification of pulp and corn stover was done, and then carbohydrates generated from hydrolysis were used by L. delbrueckii and converted to D-lactic acid with high purity (99.8 %). The authors highlighted that the SHF process, compared with the SSF process, avoids substrate inhibition and increases the productivity and the yield of D-lactic acid [107]. The same researchers’ team has then engineered a strain of L. plantarum, introducing gene encoding isomerase and xylulokinase, for the overproduction of D-lactic acid from corn stover and soybean meal extract. In this work, the authors optimized the culture medium through response surface methodology using saccharified corn stover as carbon source and soybean meal extract as a nitrogen source to substitute YE in the medium to produce high purity of D-lactic acid (99%). A maximum productivity of 0.82 g L−1 h−1 of D-lactic acid was obtained in the optimized medium, 10% higher than with YE as the main nitrogen source [106].
Saccharification and fermentation could be performed at the same time (simultaneous saccharification and fermentation) and have been used for instance by Tu et al. for LA production. With L. plantarum, they obtained up to 65.6 g L−1 of lactic acid with a cellulose conversion of 69% [110]. Using inulin from chicory, in [111] they obtained a better performance by simultaneous saccharification and fermentation to produce D-lactic acid with L. bulgaricus. In their process, they obtained an optically pure molecule (99.9%), which could be interesting for further chemical processes. Productivity is also high with 123 g L−1 starting from 120 g L−1 of inulin treated by inulinase. The enzymatic treatment yielded inulin, which was used instead of glucose in MRS medium for fermentation [110, 111].
In another example, lactic acid production from fermented orange peels was evaluated by ion-exchange chromatography. The solid fermentations were in mono or coculture, with L. casei 2246, L. plantarum 285, and L. paracasei 4186. This study showed that fermentation resulted in higher lactic acid production with the monoculture L. casei 2246 and the coculture L. casei 2246 with L. plantarum 285. Glucose can also be converted to lactic acid by symbiotic relationship between different lactic acid bacteria. L. helveticus is an AA-producing strain (alanine, serine, aspartate, glutamate, aromatic AA, and histidine), whereas L. delbrueckii is a lactic-acid-producing strain but produces little of these AAs necessary for its growth. Thus, this co-fermentation optimized the lactic acid yield [104]. Before industrialization of such a process, scale-up has to be demonstrated and downstream processes (purification) to be implemented and considered. However, another technology could also be used for lactic acid production by microorganisms. Indeed, solid-state fermentation was used with cassava bagasse as substrate and L. delbruechii as microorganism [103, 112].
3.4 Other applications of active ingredients produced from fermented plant extracts
Another biotechnology application is the production of proteins, peptides, or AA such as GABA. Indeed, plant by-products are sources of different proteins, which can be hydrolyzed during fermentation by Lactobacillus species. These microorganisms, especially L. plantarum, have developed a proteolytic system to satisfy their nitrogen requirements. The proteolytic activities and protein hydrolysis patterns are very different from one strain to another. The resulting peptides displayed different biological functions such as angiotensin-converting enzyme inhibition, mineral binding, antidiabetic, satiating, immunomodulating, opioid, AO, or antimicrobial activities [12]. The L. plantarum LP-9 strain was used to coproduce GABA and lactic acid from agri-residues such as wheat bran, rice bran, corn bran. The results were compared with the use of cassava (starchy food crop), and the production yields were significant and comparable to this control condition [113]. Co-fermentation of Ginseng root and leaf extract always by L. plantarum EJ2014 and B. subtilis, also showed GABA production [114]. The fermentation of Kimchi by L. brevis BJ20 allows the conversion of glutamic acid into GABA. This process is particularly interesting because GABA has an AO activity demonstrated during the study of DPPH scavenging, superoxide scavenging, and xanthine oxidase inhibition tests [115]. Biotechnology also allows production of cosmetic or pharmaceutical products or surfactants. Biosurfactants production was investigated using L. paracasei on enzymatically hydrolyzed vineyard pruning waste. This study presented the complete process for this waste valorization using acid hydrolysis, delignification, and enzymatic hydrolysis steps. Authors have demonstrated the impact of the carbon source extraction process on the biosurfactant composition produced by the strain L. paracasei A20 [116].
4. Limitations and future challenges
Faced with environmental and societal problems such as pollution, global warming, and overpopulation, crop yields are increasingly challenging to sustain. Moreover, while demand is increasing in developed countries, poor populations are struggling to feed themselves, and undernutrition is high in these countries. This is why the food and agriculture industry must find solutions to meet the needs of all. Among these, better use of plant resources and better exploitation of their by-products are two solutions of interest. In addition, consumers are looking for more natural and healthy products, and industrials are looking for economically viable bio-based solutions. Fruit and vegetable waste and cereal by-products are likely to be reused because of their quantity and richness in nutrients and bacterial strains suitable for lactic fermentation.
When lactic acid bacteria ferment the nutrients in them, the functional and nutritional properties increase, representing significant opportunities for the agri-food, biotechnology, medical, nutraceutical, and cosmetic industries. As presented in this chapter, the fermentation of plant products by Lactobacillus allows the production of numerous bioactive molecules for the development of many applications. Nevertheless, to meet the demand, lactic acid fermentation by Lactobacillus requires optimization. First of all, the use of plant by-products requires a crucial design of the fermentation process according to the raw material (solid, liquid, semiliquid fermentations). This design could lead to the development and emergence of new processes that should be able to meet industrial viability, economic returns, and consumer needs. Therefore, much work is still needed on these processes to increase the commercialization of new bio-based products from plant by-products. On the other hand, Lactobacillus strains are fastidious bacteria in their nutritional requirements and are not necessarily well adapted metabolically for growth from any substrate, and the use of GMOs is a very limiting criterion for many applications (food, cosmetics, etc.). The growth parameters and enzymatic activities of Lactobacillus strains have a major impact on applications, particularly when the fermentation substrate is complex. It is therefore necessary to work on the culture conditions and metabolic adaptation of these strains in order to maximize the enzymatic activities and production rates of the molecules of interest. Therefore, many constraints exist, such as the lack of scientific data and hindsight, the control of culture conditions, and the separation and purification processes to recover bioactive compounds. Further efforts are urgently needed to overcome these problems. Nevertheless, one of the advantages of production with Lactobacillus is its ability to produce several types of molecules simultaneously, typically lactic acid and other molecules (derived or transformed from the substrate), which makes the fermentation process industrially interesting. Such multiproduct strategies should be promoted in the near future up to industrial scale.
5. Conclusion
Lactic acid fermentation is an ancestral process performed by numerous bacterial strains. Fermentation conditions, substrates, and potential additives represent challenges and constraints for yield optimization, process stabilization, and standardization. Indeed, lactic fermentation by Lactobacillus allows the production of many molecules of interest. When these bacteria ferment plant products, they induce biochemical conversions and the production of phenolic compounds, organic acids, and vitamins through their enzymatic activities. This review highlights the different applications related to the production of these compounds. The latter have bioactivities such as AO, AI, prebiotic, antimicrobial, and many others.
In addition, they are of growing interest to the food industry for their ability to increase nutritional value but also for their use as preservatives and modifiers of organoleptic properties. The different studies reviewed here are looking for alternatives to meet environmental and social consumer demand. In order to reduce production costs and the carbon footprint of the process, genetic engineering and the revalorization of plant by-products appear to be interesting avenues of research to improve the yield of compounds of interest. However, there is still a lack of scientific data on the control of fermentation by Lactobacillus. Further studies are needed to identify the biochemical reactions and metabolism of Lactobacillus involved in the production of bioactive compounds. In addition, studies are needed to further investigate the mechanisms involved in the bioactivities of interest.
Acknowledgments
The authors would like to thank the financial support for the Charles Viollette Industrial Chair provided by the Lille European Metropolis (MEL) and the Isite of the University of Lille.
\n',keywords:"lactobacillus genera, lactic acid fermentation, by-product valorization, bioactivities, health benefits",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/81934.pdf",chapterXML:"https://mts.intechopen.com/source/xml/81934.xml",downloadPdfUrl:"/chapter/pdf-download/81934",previewPdfUrl:"/chapter/pdf-preview/81934",totalDownloads:16,totalViews:0,totalCrossrefCites:0,dateSubmitted:"December 17th 2021",dateReviewed:"April 15th 2022",datePrePublished:"July 22nd 2022",datePublished:null,dateFinished:"May 24th 2022",readingETA:"0",abstract:"Today, plant production is increasing, but most industrial processes generate a lot of waste and by-products for which, in the current context, it is a priority to recycle or valorize them. One of the cheapest valorization routes is fermentation, in particular lactic fermentation by Lactobacillus species, which produces lactic acid and other molecules of industrial interest such as bioactive compounds such as anthocyanin, organic acid, peptides, or phenol, which are widely found in the plant matrix, mainly in cereals, grass, fruits, and vegetables. Bioactive compounds may exert beneficial health effects, such as antioxidant, anti-inflammatory, antimicrobial, or prebiotic activities. In addition, lactic acid fermentation can improve existing products and lead to new applications in food, livestock feeding and biotechnology, such as the production of lactic acid, protein, or silage. This chapter reviews the use of Lactobacillus strains in the fermentation process of many plant bioresources or by-products through their different bioactivities, active molecules, and applications.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/81934",risUrl:"/chapter/ris/81934",signatures:"Morgan Le Rouzic, Pauline Bruniaux, Cyril Raveschot, François Krier, Vincent Phalip, Rozenn Ravallec, Benoit Cudennec and François Coutte",book:{id:"11372",type:"book",title:"Lactobacillus - A Multifunctional Genus",subtitle:null,fullTitle:"Lactobacillus - A Multifunctional Genus",slug:null,publishedDate:null,bookSignature:"Dr. Marta Laranjo",coverURL:"https://cdn.intechopen.com/books/images_new/11372.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-445-7",printIsbn:"978-1-80355-444-0",pdfIsbn:"978-1-80355-446-4",isAvailableForWebshopOrdering:!0,editors:[{id:"95242",title:"Dr.",name:"Marta",middleName:null,surname:"Laranjo",slug:"marta-laranjo",fullName:"Marta Laranjo"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Bioactivities resulting from the fermentation of plant products or by-products by Lactobacillus genera",level:"1"},{id:"sec_2_2",title:"2.1 Antioxidant activity",level:"2"},{id:"sec_3_2",title:"2.2 Anti-inflammatory activity",level:"2"},{id:"sec_4_2",title:"2.3 Antimicrobial activity",level:"2"},{id:"sec_5_2",title:"2.4 Prebiotic activity",level:"2"},{id:"sec_6_2",title:"2.5 Other bioactivities related to medicine",level:"2"},{id:"sec_8",title:"3. Applications",level:"1"},{id:"sec_8_2",title:"3.1 Food products",level:"2"},{id:"sec_9_2",title:"3.2 Livestock feeding",level:"2"},{id:"sec_10_2",title:"3.3 Lactic acid production from plant biomass",level:"2"},{id:"sec_11_2",title:"3.4 Other applications of active ingredients produced from fermented plant extracts",level:"2"},{id:"sec_13",title:"4. Limitations and future challenges",level:"1"},{id:"sec_14",title:"5. Conclusion",level:"1"},{id:"sec_15",title:"Acknowledgments",level:"1"},{id:"sec_15",title:"Acronyms and abbreviations",level:"1"}],chapterReferences:[{id:"B1",body:'Lugtenberg BJJ, Malfanova N, Kamilova F, Berg G. Plant growth promotion by Microbes. Molecular Microbial Ecology of the Rhizosphere. 2013;559-573'},{id:"B2",body:'Hérault B. La demande alimentaire en 2050 : chiffres, incertitudes et marges de manœuvre. Ministère de l’Agriculture, de l’Alimentation, de la Pêche, de la Ruralité et de l’Aménagement du territoire; 2011. Report No.: 27'},{id:"B3",body:'Department of Economic and Social Affairs, Sustainable Development. THE 17 GOALS | Sustainable Development [Internet]. Organisation des Nations Unies. Available from: https://sdgs.un.org/fr/goals'},{id:"B4",body:'Septembre-Malaterre A, Remize F, Poucheret P. Fruits and vegetables, as a source of nutritional compounds and phytochemicals: Changes in bioactive compounds during lactic fermentation. Food Research International. 2018;104:86-99'},{id:"B5",body:'Dogan K, Tornuk F. Improvement of bioavailability of bioactive compounds of medicinal herbs by drying and fermentation with Lactobacillus plantarum. Functional Foods in Health and Disease. 2019;9(12):735-748'},{id:"B6",body:'Ravindran R, Jaiswal AK. Exploitation of food industry waste for high-value products. Trends in Biotechnology. 2016;34(1):58-69'},{id:"B7",body:'Görgüç A, Gençdağ E, Yılmaz FM. Bioactive peptides derived from plant origin by-products: Biological activities and techno-functional utilizations in food developments—A review. Food Research International. 2020;136:109504'},{id:"B8",body:'Bustamante D, Tortajada M, Ramón D, Rojas A. Production of D-lactic acid by the fermentation of orange peel waste hydrolysate by lactic acid bacteria. Fermentation. 2020;6(1):1'},{id:"B9",body:'Wang J, Jiang L, Sun H. Early evidence for beer drinking in a 9000-year-old platform mound in southern China. PLoS One. 2021;16(8):e0255833'},{id:"B10",body:'Capurso L. Thirty Years of Lactobacillus rhamnosus GG: A Review. Journal of Clinical Gastroenterology. 2019;53(Supplement 1):S1-S41'},{id:"B11",body:'Hill D, Sugrue I, Tobin C, Hill C, Stanton C, Ross RP. The lactobacillus casei group: History and health related applications. Frontiers in Microbiology. 2018;9:2107'},{id:"B12",body:'Raveschot C, Cudennec B, Coutte F, Flahaut C, Fremont M, Drider D, et al. Production of bioactive peptides by lactobacillus species: From gene to application. Frontiers in Microbiology. 2018;9:2354'},{id:"B13",body:'Zheng J, Wittouck S, Salvetti E, Franz CMAP, Harris HMB, Mattarelli P, et al. A taxonomic note on the genus Lactobacillus: Description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae. International Journal of Systematic and Evolutionary Microbiology. 2020;70(4):2782-2858'},{id:"B14",body:'Muñoz R, de las Rivas B, de Felipe FL, Reverón I, Santamaría L, Esteban-Torres M, et al. Biotransformation of phenolics by lactobacillus plantarum in fermented foods. In Fermented Foods in Health and Disease Prevention. 2017. pp. 63-83'},{id:"B15",body:'Carpinelli Macedo JV, de Barros Ranke FF, Escaramboni B, Campioni TS, Fernández Núñez EG, de Oliva Neto P. Cost-effective lactic acid production by fermentation of agro-industrial residues. Biocatalysis and Agricultural Biotechnology. 2020;27:101706'},{id:"B16",body:'Hur SJ, Lee SY, Kim Y-C, Choi I, Kim G-B. Effect of fermentation on the antioxidant activity in plant-based foods. Food Chemistry. 2014;160:346-356'},{id:"B17",body:'Ruiz Rodríguez LG, Zamora Gasga VM, Pescuma M, Van Nieuwenhove C, Mozzi F, Sánchez Burgos JA. Fruits and fruit by-products as sources of bioactive compounds. Benefits and trends of lactic acid fermentation in the development of novel fruit-based functional beverages. Food Research International. 2021;140:109854'},{id:"B18",body:'Bintsis T. Department of Agricultural Technology, TEI of West Macedonia, 53100 Florina, Greece. Lactic acid bacteria as starter cultures: An update in their metabolism and genetics. AIMS Microbiology. 2018;4(4):665-684'},{id:"B19",body:'Landete JM, Rodriguez H, De Las RB, Munoz R. High-added-value antioxidants obtained from the degradation of wine phenolics by lactobacillus plantarum. Journal of Food Protection. 2007;70(11):2670-2675'},{id:"B20",body:'Zhou Y, Wang R, Zhang Y, Yang Y, Sun X, Zhang Q , et al. Biotransformation of phenolics and metabolites and the change in antioxidant activity in kiwifruit induced by Lactobacillus plantarum fermentation. Journal of the Science of Food and Agriculture. 2020;100(8):3283-3290'},{id:"B21",body:'Kagkli DM, Corich V, Bovo B, Lante A, Giacomini A. Antiradical and antimicrobial properties of fermented red chicory (Cichorium intybus L.) by-products. Annals of Microbiology. 2016;66(4):1377-1386'},{id:"B22",body:'Leonard W, Zhang P, Ying D, Adhikari B, Fang Z. Fermentation transforms the phenolic profiles and bioactivities of plant-based foods. Biotechnology Advances. 2021;49:107763'},{id:"B23",body:'Feng Y, Zhang M, Mujumdar AS, Gao Z. Turmeric Extract: Potential Use as a Prebiotic and Anti-Inflammatory Compound? Trends in Food Science & Technology. 2017;65:40-48'},{id:"B24",body:'Pianpumepong P, Anal AK, Doungchawee G, Noomhorm A. Study on enhanced absorption of phenolic compounds of Lactobacillus-fermented turmeric (Curcuma longa Linn.) beverages in rats. International Journal of Food Science & Technology. 2012;47(11):2380-2387'},{id:"B25",body:'Singhal B, Pundhir A, Maurya A. In vitro evaluation of functional attributes of LABs for the development of turmeric based probiotic beverage. American Journal of Research Communication. 2016;4:141-173'},{id:"B26",body:'Wang M, Lei M, Samina N, Chen L, Liu C, Yin T, et al. Impact of Lactobacillus plantarum 423 fermentation on the antioxidant activity and flavor properties of rice bran and wheat bran. Food Chemistry. 2020;330:127156'},{id:"B27",body:'Mukherjee R, Chakraborty R, Dutta A. Comparison of optimization approaches (response surface methodology and artificial neural network-genetic algorithm) for a novel mixed culture approach in soybean meal fermentation. Journal of Food Process Engineering. 2019;42(5):e13124'},{id:"B28",body:'Cheng Y, Wu T, Chu X, Tang S, Cao W, Liang F, et al. Fermented blueberry pomace with antioxidant properties improves fecal microbiota community structure and short chain fatty acids production in an in vitro mode. LWT. 2020;125:109260'},{id:"B29",body:'Kwaw E, Ma Y, Tchabo W, Apaliya MT, Wu M, Sackey AS, et al. Effect of lactobacillus strains on phenolic profile, color attributes and antioxidant activities of lactic-acid-fermented mulberry juice. Food Chemistry. 2018;250:148-154'},{id:"B30",body:'Lizardo RCM, Cho HD, Won YS, Seo KI. Fermentation with mono- and mixed cultures of Lactobacillus plantarum and L. casei enhances the phytochemical content and biological activities of cherry silverberry (Elaeagnus multiflora Thunb.) fruit. Journal of the Science of Food and Agriculture. 2020;100(9):3687-3696'},{id:"B31",body:'Frediansyah A, Romadhoni F, Nurhayati R, Wibowo AT. Fermentation of jamaican cherries juice using lactobacillus plantarum elevates antioxidant potential and inhibitory activity against type II diabetes-related enzymes. Molecules. 2021;26(10):2868'},{id:"B32",body:'Goto M, Kuda T, Shikano A, Charrouf Z, Yamauchi K, Yokozawa M, et al. Induction of superoxide anion radical-scavenging c. LWT. 2019;100:56-61'},{id:"B33",body:'Jung J, Jang HJ, Eom SJ, Choi NS, Lee N-K, Paik H-D. Fermentation of red ginseng extract by the probiotic Lactobacillus plantarum KCCM 11613P: ginsenoside conversion and antioxidant effects. Journal of Ginseng Research. 2019;43(1):20-26'},{id:"B34",body:'Marazza JA, Nazareno MA, de Giori GS, Garro MS. Enhancement of the antioxidant capacity of soymilk by fermentation with Lactobacillus rhamnosus. Journal of Functional Foods. 2012;4(3):594-601'},{id:"B35",body:'Li Z, Teng J, Lyu Y, Hu X, Zhao Y, Wang M. Enhanced antioxidant activity for apple juice fermented with lactobacillus plantarum ATCC14917. Molecules. 2019;24(1):51'},{id:"B36",body:'Li H, Huang J, Wang Y, Wang X, Ren Y, Yue T, et al. Study on the nutritional characteristics and antioxidant activity of dealcoholized sequentially fermented apple juice with Saccharomyces cerevisiae and Lactobacillus plantarum fermentation. Food Chemistry. 2021;363:130351'},{id:"B37",body:'Gao H, Wen J-J, Hu J-L, Nie Q-X, Chen H-H, Nie S-P, et al. Momordica charantia juice with Lactobacillus plantarum fermentation: Chemical composition, antioxidant properties and aroma profile. Food Bioscience. 2019;29:62-72'},{id:"B38",body:'Wu S-C, Su Y-S, Cheng H-Y. Antioxidant properties of Lactobacillus-fermented and non-fermented Graptopetalum paraguayense E. Walther at different stages of maturity. Food Chemistry. 2011;129(3):804-809'},{id:"B39",body:'Reque PM, Pinilla CMB, Tinello F, Corich V, Lante A, Giacomini A, et al. Biochemical and functional properties of wheat middlings bioprocessed by lactic acid bacteria. Journal of Food Biochemistry. 2020;44(7):e13262'},{id:"B40",body:'Tlais AZA, Da Ros A, Filannino P, Vincentini O, Gobbetti M, Di Cagno R. Biotechnological re-cycling of apple by-products: A reservoir model to produce a dietary supplement fortified with biogenic phenolic compounds. Food Chemistry. 2021;336:127616'},{id:"B41",body:'Jin X, Chen W, Chen H, Chen W, Zhong Q. Combination of Lactobacillus plantarum and Saccharomyces cerevisiae DV10 as Starter Culture to Produce Mango Slurry: Microbiological. Chemical Parameters and Antioxidant Activity. Molecules. 2019;24(23):4349'},{id:"B42",body:'Mousavi ZE, Mousavi M. The effect of fermentation by Lactobacillus plantarum on the physicochemical and functional properties of liquorice root extract. LWT. 2019;105:164-168'},{id:"B43",body:'Braga ARC, de Mesquita LMS, PLG M, Habu S, de Rosso VV. Lactobacillus fermentation of jussara pulp leads to the enzymatic conversion of anthocyanins increasing antioxidant activity. Journal of Food Composition and Analysis. 2018;69:162-170'},{id:"B44",body:'Vieira ADS, Battistini C, Bedani R, Saad SMI. Acerola by-product may improve the in vitro gastrointestinal resistance of probiotic strains in a plant-based fermented beverage. LWT. 2021;141:110858'},{id:"B45",body:'Thompson HO, Önning G, Holmgren K, Strandler HS, Hultberg M. Fermentation of Cauliflower and White Beans with Lactobacillus plantarum—Impact on Levels of Riboflavin, Folate, Vitamin B12, and Amino Acid Composition. Plant Foods for Human Nutrition. 2020;75(2):236-242'},{id:"B46",body:'Rizzello CG, Nionelli L, Coda R, De Angelis M, Gobbetti M. Effect of sourdough fermentation on stabilisation, and chemical and nutritional characteristics of wheat germ. Food Chemistry. 2010;119(3):1079-1089'},{id:"B47",body:'Nancib A, Nancib N, Meziane-Cherif D, Boubendir A, Fick M, Boudrant J. Joint effect of nitrogen sources and B vitamin supplementation of date juice on lactic acid production by Lactobacillus casei subsp. rhamnosus. Bioresource Technology. 2005;96(1):63-67'},{id:"B48",body:'Chauhan K, Trivedi U, Patel KC. Statistical screening of medium components by Plackett–Burman design for lactic acid production by Lactobacillus sp. KCP01 using date juice. Bioresource Technology. 2007;98(1):98-103'},{id:"B49",body:'Bahry H, Abdalla R, Pons A, Taha S, Vial C. Optimization of lactic acid production using immobilized Lactobacillus Rhamnosus and carob pod waste from the Lebanese food industry. Journal of Biotechnology. 2019;306:81-88'},{id:"B50",body:'Ngouénam JR, Momo Kenfack CH, Foko Kouam EM, Kaktcham PM, Maharjan R, Ngoufack FZ. Lactic acid production ability of Lactobacillus sp. from four tropical fruits using their by-products as carbon source. Heliyon. 2021;7(5):e07079'},{id:"B51",body:'Kim J, Choi K-B, Park JH, Kim KH. Metabolite profile changes and increased antioxidative and antiinflammatory activities of mixed vegetables after fermentation by Lactobacillus plantarum. PLOS ONE. 2019;14(5):e0217180'},{id:"B52",body:'Shahbazi R, Sharifzad F, Bagheri R, Alsadi N, Yasavoli-Sharahi H, Matar C. Anti-inflammatory and immunomodulatory properties of fermented plant foods. Nutrients. 2021;13(5):1516'},{id:"B53",body:'Chon H, Kim G, Kim S. Comparison of aqueous plant extracts before and after fermentation with lactobacillus paracasei LS-2 on cytokine induction and antioxidant activity. Natural Product Communications. 2010;5(8):1934578X1000500827'},{id:"B54",body:'Ali MS, Lee E-B, Lee S-J, Lee S-P, Boby N, Suk K, et al. Aronia melanocarpa extract fermented by lactobacillus plantarum EJ2014 modulates immune response in mice. Antioxidants. 2021;10(8):1276'},{id:"B55",body:'Kim K, Lee G, Thanh HD, Kim J-H, Konkit M, Yoon S, et al. Exopolysaccharide from Lactobacillus plantarum LRCC5310 offers protection against rotavirus-induced diarrhea and regulates inflammatory response. Journal of Dairy Science. 2018;101(7):5702-5712'},{id:"B56",body:'Kim S-B, Kang B-H, Kwon H-S, Kang J-H. Antiinflammatory and antiallergic activity of fermented turmeric by lactobacillus johnsonii IDCC 9203. Microbiology and Biotechnology Letters. 2011;39(3):266-273'},{id:"B57",body:'Ghiamati Yazdi F, Soleimanian-Zad S, van den Worm E, Folkerts G. Turmeric extract: Potential use as a prebiotic and anti-inflammatory compound? Plant Foods Hum Nutr. 2019;74(3):293-299'},{id:"B58",body:'Yong CC, Yoon Y, Yoo HS, Oh S. Effect of lactobacillus fermentation on the anti-inflammatory potential of turmeric. Journal of Microbiology and Biotechnology. 2019;29(10):1561-1569'},{id:"B59",body:'Ayivi RD, Gyawali R, Krastanov A, Aljaloud SO, Worku M, Tahergorabi R, et al. Lactic acid bacteria: Food safety and human health applications. Dairy. 2020;1(3):202-232'},{id:"B60",body:'Cotârleț M, Stănciuc N, Bahrim GE. Yarrowia lipolytica and lactobacillus paracasei solid state fermentation as a valuable biotechnological tool for the Pork Lard and Okara’s biotransformation. Microorganisms. 2020;8(8):1098'},{id:"B61",body:'Kothari D, Lee W-D, Jung ES, Niu K-M, Lee CH, Kim S-K. Controlled fermentation using autochthonous lactobacillus plantarum improves antimicrobial potential of chinese chives against poultry pathogens. Antibiotics. 2020;9(7):386'},{id:"B62",body:'Dallagnol AM, Pescuma M, De Valdez GF, Rollán G. Fermentation of quinoa and wheat slurries by Lactobacillus plantarum CRL 778: Proteolytic activity. Applied Microbiology and Biotechnology. 2013;97(7):3129-3140'},{id:"B63",body:'Hashemi SMB, Mousavi Khaneghah A, Barba FJ, Nemati Z, Sohrabi Shokofti S, Alizadeh F. Fermented sweet lemon juice (Citrus limetta) using Lactobacillus plantarum LS5: Chemical composition, antioxidant and antibacterial activities. Journal of Functional Foods. 2017;38:409-414'},{id:"B64",body:'Beck MR, Garrett K, Marshall CJ, Olejar K, Bunt CR, Maxwell TMR, et al. Lactobacillus fermented plant extracts provided to yearling ewes improves their lambs’ antioxidant status at weaning. Animal Feed Science and Technology. 2021;281:115103'},{id:"B65",body:'Uerlings J, Schroyen M, Bautil A, Courtin C, Richel A, Sureda EA, et al. In vitro prebiotic potential of agricultural by-products on intestinal fermentation, gut barrier and inflammatory status of piglets. British Journal of Nutrition. 2020;123(3):293-307'},{id:"B66",body:'Zhang Z-P, Ma J, He Y-Y, Lu J, Ren D-F. Antioxidant and hypoglycemic effects of diospyros lotus fruit fermented with Microbacterium flavum and Lactobacillus plantarum. Journal of Bioscience and Bioengineering. 2018;125(6):682-687'},{id:"B67",body:'Park S, Son H-K, Chang H-C, Lee J-J. Effects of cabbage-apple juice fermented by lactobacillus plantarum EM on lipid profile improvement and obesity amelioration in rats. Nutrients. 2020;12(4):1135'},{id:"B68",body:'Ryu J-Y, Kang HR, Cho SK. Changes over the fermentation period in phenolic compounds and antioxidant and anticancer activities of blueberries fermented by lactobacillus plantarum. Journal of Food Science. 2019;84(8):2347-2356'},{id:"B69",body:'Pontonio E, Dingeo C, Gobbetti M, Rizzello CG. Maize milling by-products: From food wastes to functional ingredients through lactic acid bacteria fermentation. Frontiers in Microbiology. 2019;10:561'},{id:"B70",body:'Pontonio E, Dingeo C, Di Cagno R, Blandino M, Gobbetti M, Rizzello CG. Brans from hull-less barley, emmer and pigmented wheat varieties: From by-products to bread nutritional improvers using selected lactic acid bacteria and xylanase. International Journal of Food Microbiology. 2020;313:108384'},{id:"B71",body:'Chen H-Y, Hsieh C-W, Chen P-C, Lin S-P, Lin Y-F, Cheng K-C. Development and optimization of djulis sourdough bread fermented by lactic acid bacteria for antioxidant capacity. Molecules. 2021;26(18):5658'},{id:"B72",body:'Schettino R, Pontonio E, Rizzello CG. Use of fermented hemp, chickpea and milling by-products to improve the nutritional value of semolina pasta. Foods. 2019;8(12):604'},{id:"B73",body:'Brückner-Gühmann M, Banovic M, Drusch S. Towards an increased plant protein intake: Rheological properties, sensory perception and consumer acceptability of lactic acid fermented, oat-based gels. Food Hydrocolloids. 2019;96:201-208'},{id:"B74",body:'Kachouri F, Hamdi M. Use lactobacillus plantarum in olive oil process and improvement of phenolic compounds content. Journal of Food Engineering. 2006;77(3):746-752'},{id:"B75",body:'Ruiz-Barba J, Brenes-Balbuena M, Jiménez-Díaz R, García-García P, Garrido-Fernández A. Inhibition of Lactobacillus plantarum by polyphenols extracted from two different kinds of olive brine. Journal of Applied Bacteriology. 1993;74(1):15-19'},{id:"B76",body:'Leal-Sánchez MV, Ruiz-Barba JL, Sánchez AH, Rejano L, Jiménez-Dı́az R, Garrido A. Fermentation profile and optimization of green olive fermentation using lactobacillus plantarum LPCO10 as a starter culture. Food Microbiology. 2003;20(4):421-430'},{id:"B77",body:'Landete JM, Curiel JA, Rodríguez H, de las Rivas B, Muñoz R. Study of the inhibitory activity of phenolic compounds found in olive products and their degradation by Lactobacillus plantarum strains. Food Chemistry. 2008;107(1):320-326'},{id:"B78",body:'Ciafardini G, Marsilio V, Lanza B, Pozzi N. Hydrolysis of Oleuropein by Lactobacillus plantarum Strains Associated with Olive Fermentation. Applied and Environmental Microbiology. 1994;60(11):4142-4147'},{id:"B79",body:'Ruiz-Barba JL, Cathcart DP, Warner PJ, Jiménez-Díaz R. Use of Lactobacillus plantaru LPCO10, a Bacteriocin Producer, as a Starter Culture in Spanish-Style Green Olive Fermentations. Applied and Environmental Microbiology. 1994;60(6):2059-2064'},{id:"B80",body:'Kachouri F, Setti K, Ksontini H, Mechmeche M, Hamdi M. Improvement of antioxidant activity of olive mill wastewater phenolic compounds by Lactobacillus plantarum fermentation. Desalination and Water Treatment. 2016;57(56):27125-27137'},{id:"B81",body:'Tangyu M, Muller J, Bolten CJ, Wittmann C. Fermentation of plant-based milk alternatives for improved flavour and nutritional value. Applied and Microbiology Biotechnology. 2019;103(23-24):9263-9275'},{id:"B82",body:'Do TVT, Fan L. Probiotic viability, qualitative characteristics, and sensory acceptability of vegetable juice mixture fermented with lactobacillus strains. Food and Nutrition Sciences. 2019;10(04):412'},{id:"B83",body:'Cui S, Zhao N, Lu W, Zhao F, Zheng S, Wang W, et al. Effect of different Lactobacillus species on volatile and nonvolatile flavor compounds in juices fermentation. Food Science & Nutrition. 2019;7(7):2214-2223'},{id:"B84",body:'Bianchi F, Rossi EA, Gomes RG, Sivieri K. Potentially synbiotic fermented beverage with aqueous extracts of quinoa (Chenopodium quinoa Willd) and soy. Food Science and Technology International. 2015;21(6):403-415'},{id:"B85",body:'Yoon KY, Woodams EE, Hang YD. Production of probiotic cabbage juice by lactic acid bacteria. Bioresource Technology. 2006;97(12):1427-1430'},{id:"B86",body:'Lavinia BC, Manea I, Bratu MG, Avram D, Nicolescu CL. Evaluation of the cabbage and cucumber juices as substrate for Lactobacillus acidophilus LA-5. Romanian Biotechnological Letters. 2012;17(4):12'},{id:"B87",body:'Karovičová J, Drdák M, Greif G, Hybenová E. The choice of strains of Lactobacillus species for the lactic acid fermentation of vegetable juices. European Food Research and Technology. 1999;210(1):53-56'},{id:"B88",body:'Jang H, Kim M. Characteristics of vegetable juice fermented with lactobacillus plantarum MKHA15 and leuconostoc mesenteroids MKSR. Journal of the Korean Dietetic Association. 2019;25(4):281-294'},{id:"B89",body:'Dunkley KE, Hekmat S. Development of probiotic vegetable juice using Lactobacillus Rhamnosus GR-1. Nutrition & Food Science. 2020;50(5):955-968'},{id:"B90",body:'Hashemi SMB, Jafarpour D. Fermentation of bergamot juice with Lactobacillus plantarum strains in pure and mixed fermentations: Chemical composition, antioxidant activity and sensorial properties. LWT. 2020;131:109803'},{id:"B91",body:'Gupta S, Jaiswal AK, Abu-Ghannam N. Optimization of fermentation conditions for the utilization of brewing waste to develop a nutraceutical rich liquid product. Industrial Crops and Products. 2013;44:272-282'},{id:"B92",body:'Oktaviani L, Astuti DI, Rosmiati M, Abduh MY. Fermentation of coffee pulp using indigenous lactic acid bacteria with simultaneous aeration to produce cascara with a high antioxidant activity. Heliyon. 2020;6(7):e04462'},{id:"B93",body:'Nguyen NK, Dong NTN, Nguyen HT, Le PH. Lactic acid bacteria: promising supplements for enhancing the biological activities of kombucha. SpringerPlus. 2015;4(1):91'},{id:"B94",body:'Nguyen NK, Dong NTN, Le PH, Nguyen HT. Evaluation of the glucuronic acid production and other biological activities of fermented sweeten-black tea by kombucha layer and the co-culture with different lactobacillus sp. strains. International Journal Of Modern Engineering Research. 2014;4(5):12-17'},{id:"B95",body:'Hou J, Luo R, Ni H, Li K, Mgomi FC, Fan L, et al. Antimicrobial potential of kombucha against foodborne pathogens: A review. qas. 2021;13(3):53-61'},{id:"B96",body:'Park JH, Kim Y, Kim SH. Green tea extract (camellia sinensis) fermented by lactobacillus fermentum attenuates alcohol-induced liver damage. Bioscience, Biotechnology, and Biochemistry. 2012;76(12):2294-2300'},{id:"B97",body:'Cherdthong A, Suntara C, Khota W. Lactobacillus casei TH14 and additives could modulate the quality, gas kinetics and the in vitro digestibility of ensilaged rice straw. Journal of Animal Physiology and Animal Nutrition. 2020;104(6):1690-1703'},{id:"B98",body:'Xu Z, He H, Zhang S, Kong J. Effects of inoculants Lactobacillus brevis and Lactobacillus parafarraginis on the fermentation characteristics and microbial communities of corn stover silage. Scientific Reports. 2017;7(1):13614'},{id:"B99",body:'Irsyammawati A, Ndaru PH. The effect of lactobacillus plantarum addition and fermentation periods on nutritive value dwarf elephant grass (pennisetum purpureum cv mott) silage. IOP Conference Series: Earth Environmental Science. 2020;478:012049'},{id:"B100",body:'Zhao J, Dong Z, Li J, Chen L, Bai Y, Jia Y, et al. Evaluation of Lactobacillus plantarum MTD1 and waste molasses as fermentation modifier to increase silage quality and reduce ruminal greenhouse gas emissions of rice straw. Science of The Total Environment. 2019;688:143-152'},{id:"B101",body:'Mu L, Xie Z, Hu L, Chen G, Zhang Z. Lactobacillus plantarum and molasses alter dynamic chemical composition, microbial community, and aerobic stability of mixed (amaranth and rice straw) silage. 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Using novel lactobacillus plantarum to produce lactic acid from lignocellulosic biomass in an integrated simultaneous saccharification and fermentation process. BioResources. 2019;14(2):3873-3885'},{id:"B111",body:'Xu Q , Zang Y, Zhou J, Liu P, Li X, Yong Q , et al. Highly efficient production of d-lactic acid from chicory-derived inulin by Lactobacillus bulgaricus. Bioprocess and Biosystem Engineering. 2016;39(11):1749-1757'},{id:"B112",body:'John RP, Nampoothiri KM, Pandey A. Solid-state fermentation for l-lactic acid product. Process Biochemistry. 2006;41(4):759-763'},{id:"B113",body:'Sharma P, Sharma A, Singh J, Singh N, Singh S, Tomar GS, et al. Co-production of gamma amino butyric acid (GABA) and lactic acid using Lactobacillus plantarum LP-9 from agro-residues. Environmental Technology & Innovation. 2021;23:101650'},{id:"B114",body:'Park J-H, Garcia CV, Lee S-P. Fortification of poly-γ-glutamic acid and γ-aminobutyric acid in homogenized hydroponic ginseng co-fermented by bacillus subtilis ha and lactobacillus plantarum EJ2014. Preventive Nutrition and Food Science. 2019;24(4):485-491'},{id:"B115",body:'Lee B-J, Kim J-S, Kang YM, Lim J-H, Kim Y-M, Lee M-S, et al. Antioxidant activity and γ-aminobutyric acid (GABA) content in sea tangle fermented by Lactobacillus brevis BJ20 isolated from traditional fermented foods. Food Chemistry. 2010;122(1):271-276'},{id:"B116",body:'Vecino X, Rodríguez-López L, Gudiña EJ, Cruz JM, Moldes AB, Rodrigues LR. Vineyard pruning waste as an alternative carbon source to produce novel biosurfactants by Lactobacillus paracasei. Journal of Industrial and Engineering Chemistry. 2017;55:40-49'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Morgan Le Rouzic",address:null,affiliation:'
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The HTML version, as well as the PDF version of publications dated before 2012 that are accessible through a reader, are available to readers with no restriction.
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IntechOpen chapters and articles are distributed under CC BY 3.0 licences allowing users to “copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship...” and there is no non-commercial restriction.
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These reactions occur through a regular radical chain causing growth of polymer by three steps, namely, initiation, propagation, and termination. To understand ionizing radiation-induced polymerization, the water radiolysis must be taken into consideration. This chapter explores the mechanism of water molecules radiolysis paying especial attention to the basic regularities of solvent radicals’ interaction with the polymer molecules for forming the crosslinked polymer. Water radiolysis is the main engine of the polymerization processes, especially the “free-radical polymerization.” The mechanisms of the free-radical polymerization and crosslinking will be discussed in detail later. Since different polymers respond differently to radiation, it is useful to quantify the response, namely in terms of crosslinking and chain scission. A parameter called the G-value is frequently used for this purpose. It represents the chemical yield of crosslinks, scissions and double bonds, etc. For the crosslinked polymer, the crosslinking density increases with increasing the radiation dose, this is reflected by the swelling degree of the polymer while being immersed in a compatible solvent. If crosslinking predominates, the crosslinking density increases and the extent of swelling decreases. If chain scission predominates, the opposite occurs. A further detailed discussion of these aspects is presented throughout this chapter.",book:{id:"6149",slug:"ionizing-radiation-effects-and-applications",title:"Ionizing Radiation Effects and Applications",fullTitle:"Ionizing Radiation Effects and Applications"},signatures:"Mohamed Mohamady Ghobashy",authors:[{id:"212371",title:"Dr.",name:"Mohamed",middleName:null,surname:"Mohamady Ghobashy",slug:"mohamed-mohamady-ghobashy",fullName:"Mohamed Mohamady Ghobashy"}]},{id:"53504",doi:"10.5772/66925",title:"Applications of Ionizing Radiation in Mutation Breeding",slug:"applications-of-ionizing-radiation-in-mutation-breeding",totalDownloads:3509,totalCrossrefCites:9,totalDimensionsCites:13,abstract:"As a predicted result of increasing population worldwide, improvements in the breeding strategies in agriculture are valued as mandatory. The natural resources are limited, and due to the natural disasters like sudden and severe abiotic stress factors, excessive floods, etc., the production capacities are changed per year. In contrast, the yield potential should be significantly increased to cope with this problem. Despite rich genetic diversity, manipulation of the cultivars through alternative techniques such as mutation breeding becomes important. Radiation is proven as an effective method as a unique method to increase the genetic variability of the species. Gamma radiation is the most preferred physical mutagen by plant breeders. Several mutant varieties have been successfully introduced into commercial production by this method. Combinational use of in vitro tissue culture and mutation breeding methods makes a significant contribution to improve new crops. Large populations and the target mutations can be easily screened and identified by new methods. Marker assisted selection and advanced techniques such as microarray, next generation sequencing methods to detect a specific mutant in a large population will help to the plant breeders to use ionizing radiation efficiently in breeding programs.",book:{id:"5451",slug:"new-insights-on-gamma-rays",title:"New Insights on Gamma Rays",fullTitle:"New Insights on Gamma Rays"},signatures:"Özge Çelik and Çimen Atak",authors:[{id:"147362",title:"Dr.",name:"Özge",middleName:null,surname:"Çelik",slug:"ozge-celik",fullName:"Özge Çelik"},{id:"147364",title:"Prof.",name:"Çimen",middleName:null,surname:"Atak",slug:"cimen-atak",fullName:"Çimen Atak"}]},{id:"32846",doi:"10.5772/36950",title:"Current Importance and Potential Use of Low Doses of Gamma Radiation in Forest Species",slug:"current-importance-and-potential-use-of-low-doses-of-gamma-radiation-in-forest-species",totalDownloads:5301,totalCrossrefCites:2,totalDimensionsCites:13,abstract:null,book:{id:"1590",slug:"gamma-radiation",title:"Gamma Radiation",fullTitle:"Gamma Radiation"},signatures:"L. G. Iglesias-Andreu, P. Octavio-Aguilar and J. Bello-Bello",authors:[{id:"110581",title:"Dr.",name:"Lourdes",middleName:null,surname:"Iglesias-Andreu",slug:"lourdes-iglesias-andreu",fullName:"Lourdes Iglesias-Andreu"}]},{id:"58410",doi:"10.5772/intechopen.72074",title:"Radiation-Induced Degradation of Organic Compounds and Radiation Technologies for Purification of Aqueous Systems",slug:"radiation-induced-degradation-of-organic-compounds-and-radiation-technologies-for-purification-of-aq",totalDownloads:1437,totalCrossrefCites:8,totalDimensionsCites:13,abstract:"Environmental application of radiation technologies is an important part of radiation processing. Radiation treatment of aqueous systems contaminated with organic compounds is a promising method of water and wastewater purification and corresponding technologies are being developed. In this chapter, the following aspects of radiation treatment process are considered: sources of contamination and major contaminants of water and wastewater; primary processes in aqueous systems initiated by ionizing radiation; principal ways of contaminant conversion as consequences of primary processes (complete mineralization of organic compounds, partial decomposition of organic molecules resulted in detoxification, decolorization, disinfection of polluted water, and improvement in biological degradation of contaminant, polymerization of monomers’ contaminants, oxidation-reduction processes, and coagulation of colloids); sources of ionizing radiation; and main equipment applied in radiation technologies of aqueous system purification.",book:{id:"6149",slug:"ionizing-radiation-effects-and-applications",title:"Ionizing Radiation Effects and Applications",fullTitle:"Ionizing Radiation Effects and Applications"},signatures:"Igor E. Makarov and Alexander V. Ponomarev",authors:[{id:"213652",title:"Dr.",name:"Igor",middleName:null,surname:"Makarov",slug:"igor-makarov",fullName:"Igor Makarov"},{id:"213657",title:"Dr.",name:"Alexander",middleName:null,surname:"Ponomarev",slug:"alexander-ponomarev",fullName:"Alexander Ponomarev"}]}],mostDownloadedChaptersLast30Days:[{id:"32842",title:"Sterilization by Gamma Irradiation",slug:"sterilization-by-gamma-irradiation",totalDownloads:74818,totalCrossrefCites:37,totalDimensionsCites:85,abstract:null,book:{id:"1590",slug:"gamma-radiation",title:"Gamma Radiation",fullTitle:"Gamma Radiation"},signatures:"Kátia Aparecida da Silva Aquino",authors:[{id:"102109",title:"Dr.",name:"Katia",middleName:"Aparecida Da S.",surname:"Aquino",slug:"katia-aquino",fullName:"Katia Aquino"}]},{id:"32837",title:"Environmental Gamma-Ray Observation in Deep Sea",slug:"environmental-gamma-ray-observation-in-deep-sea-",totalDownloads:2931,totalCrossrefCites:4,totalDimensionsCites:6,abstract:null,book:{id:"1590",slug:"gamma-radiation",title:"Gamma Radiation",fullTitle:"Gamma Radiation"},signatures:"Hidenori Kumagai, Ryoichi Iwase, Masataka Kinoshita, Hideaki Machiyama, Mutsuo Hattori and Masaharu Okano",authors:[{id:"108174",title:"Dr.",name:"Hidenori",middleName:null,surname:"Kumagai",slug:"hidenori-kumagai",fullName:"Hidenori Kumagai"},{id:"108237",title:"Dr.",name:"Masa",middleName:null,surname:"Kinoshita",slug:"masa-kinoshita",fullName:"Masa Kinoshita"},{id:"137650",title:"Dr.",name:"Ryoichi",middleName:null,surname:"Iwase",slug:"ryoichi-iwase",fullName:"Ryoichi Iwase"},{id:"137656",title:"Dr.",name:"Hideaki",middleName:null,surname:"Machiyama",slug:"hideaki-machiyama",fullName:"Hideaki Machiyama"},{id:"146918",title:"Dr.",name:"Mutsuo",middleName:null,surname:"Hattori",slug:"mutsuo-hattori",fullName:"Mutsuo Hattori"},{id:"146919",title:"Dr.",name:"Masaharu",middleName:null,surname:"Okano",slug:"masaharu-okano",fullName:"Masaharu Okano"}]},{id:"58998",title:"Ionizing Radiation-Induced Polymerization",slug:"ionizing-radiation-induced-polymerization",totalDownloads:1820,totalCrossrefCites:8,totalDimensionsCites:17,abstract:"Ionizing radiation can induce some kinds of reactions, other than polymerization, such as dimerization, oligomerization, curing, and grafting. These reactions occur through a regular radical chain causing growth of polymer by three steps, namely, initiation, propagation, and termination. To understand ionizing radiation-induced polymerization, the water radiolysis must be taken into consideration. This chapter explores the mechanism of water molecules radiolysis paying especial attention to the basic regularities of solvent radicals’ interaction with the polymer molecules for forming the crosslinked polymer. Water radiolysis is the main engine of the polymerization processes, especially the “free-radical polymerization.” The mechanisms of the free-radical polymerization and crosslinking will be discussed in detail later. Since different polymers respond differently to radiation, it is useful to quantify the response, namely in terms of crosslinking and chain scission. A parameter called the G-value is frequently used for this purpose. It represents the chemical yield of crosslinks, scissions and double bonds, etc. For the crosslinked polymer, the crosslinking density increases with increasing the radiation dose, this is reflected by the swelling degree of the polymer while being immersed in a compatible solvent. If crosslinking predominates, the crosslinking density increases and the extent of swelling decreases. If chain scission predominates, the opposite occurs. A further detailed discussion of these aspects is presented throughout this chapter.",book:{id:"6149",slug:"ionizing-radiation-effects-and-applications",title:"Ionizing Radiation Effects and Applications",fullTitle:"Ionizing Radiation Effects and Applications"},signatures:"Mohamed Mohamady Ghobashy",authors:[{id:"212371",title:"Dr.",name:"Mohamed",middleName:null,surname:"Mohamady Ghobashy",slug:"mohamed-mohamady-ghobashy",fullName:"Mohamed Mohamady Ghobashy"}]},{id:"53780",title:"Gamma-Ray Spectrometry and the Investigation of Environmental and Food Samples",slug:"gamma-ray-spectrometry-and-the-investigation-of-environmental-and-food-samples",totalDownloads:2529,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Gamma radiation consists of high‐energy photons and penetrates matter. This is an advantage for the detection of gamma rays, as gamma spectrometry does not need the elimination of the matrix. The disadvantage is the need of shielding to protect against this radiation. Gamma rays are everywhere: in the atmosphere; gamma nuclides are produced by radiation of the sun; in the Earth, the primordial radioactive nuclides thorium and uranium are sources for gamma and other radiation. The technical enrichment and use of radioisotopes led to the unscrupulously use of radioactive material and to the Cold War, with over 900 bomb tests from 1945 to 1990, combined with global fallout over the northern hemisphere. The friendly use of radiation in medicine and for the production of energy at nuclear power plants (NPPs) has caused further expositions with ionising radiation. This chapter describes in a practical manner the instrumentation for the detection of gamma radiation and some results of the use of these techniques in environmental and food investigations.",book:{id:"5451",slug:"new-insights-on-gamma-rays",title:"New Insights on Gamma Rays",fullTitle:"New Insights on Gamma Rays"},signatures:"Markus R. Zehringer",authors:[{id:"311750",title:"Dr.",name:"Markus R.",middleName:null,surname:"Zehringer",slug:"markus-r.-zehringer",fullName:"Markus R. Zehringer"}]},{id:"54118",title:"Gamma Rays from Space",slug:"gamma-rays-from-space",totalDownloads:2089,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"An overview of gamma rays from space is presented. We highlight the most powerful astrophysical explosions, known as gamma-ray bursts. The main features observed in detectors onboard satellites are indicated. In addition, we also highlight a chronological description of the efforts made to observe their high energy counterpart at ground level. Some candidates of the GeV counterpart of gamma-ray bursts, observed by Tupi telescopes, are also presented.",book:{id:"5451",slug:"new-insights-on-gamma-rays",title:"New Insights on Gamma Rays",fullTitle:"New Insights on Gamma Rays"},signatures:"Carlos Navia and Marcel Nogueira de Oliveira",authors:[{id:"189908",title:"Dr.",name:"Carlos",middleName:null,surname:"Navia",slug:"carlos-navia",fullName:"Carlos Navia"},{id:"243084",title:"MSc.",name:"Marcel",middleName:null,surname:"De Oliveira",slug:"marcel-de-oliveira",fullName:"Marcel De Oliveira"}]}],onlineFirstChaptersFilter:{topicId:"227",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82739",title:"Experimental Breeder Reactor II",slug:"experimental-breeder-reactor-ii",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.105800",abstract:"The Experimental Breeder Reactor II (EBR-II) operated from 1964 to 1994. EBR-II was a sodium-cooled fast reactor operating at 69 MWth producing 19 MWe. Rather than using a loop approach for the coolant, EBR-II used a pool arrangement where the reactor core, primary coolant piping, and primary reactor coolant pumps were contained within the pool of sodium. Also contained within the pool was a heat exchanger where primary coolant, which is radioactive, transferred heat to secondary, nonradioactive, sodium. The nuclear power plant included a sodium boiler building where heat from the secondary sodium generated superheated steam, which was delivered to a turbine/generator for electricity production. EBR-II fuel was metallic uranium alloyed with various metals providing significant performance and safety enhancements over oxide fuel. The most significant EBR-II experiments occurred in April 1986. Relying on inherent physical properties of the reactor, two experiments were performed subjecting the reactor to loss of primary coolant flow without reactor SCRAM and loss of the secondary system heat removal without reactor SCRAM. In both experiments, the reactor experienced no damage. This chapter provides a description of the most important design features of EBR-II along with a summary of the landmark reactor safety experiments.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Chad L. Pope, Ryan Stewart and Edward Lum"},{id:"82712",title:"Idaho State University AGN-201 Low Power Teaching Reactor: An Overlooked Gem",slug:"idaho-state-university-agn-201-low-power-teaching-reactor-an-overlooked-gem",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.105799",abstract:"A category of reactors called university research and teaching reactors, includes relatively high-power pool-type and low-power solid-core reactors. Many high-power university reactors are largely used for irradiations and isotope production. Their almost constant operation tends to impede student access. A university reactor can be particularly relevant to the university’s mission of preparing well-rounded students who have theoretical knowledge, reinforced by focused laboratory reactor experience. The solid-core Idaho State University Aerojet General Nucleonics (AGN) model 201 reactor operates at such a low power (5 W maximum) that it is not useful for isotope production activities. However, the AGN-201 reactor is well suited for teaching and research activities. The solid-core AGN-201 reactor requires no active cooling system, uses a simple shielding arrangement, and the very low operating power results in trivial burnup providing an operating lifetime exceeding many decades. It is thus worthwhile to examine the Idaho State University AGN-201 nuclear reactor more closely because it offers a wide range of research and teaching capabilities while being widely available to students.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Chad L. Pope and William Phoenix"},{id:"81424",title:"Core Reload Analysis Techniques in the Advanced Test Reactor",slug:"core-reload-analysis-techniques-in-the-advanced-test-reactor",totalDownloads:13,totalDimensionsCites:0,doi:"10.5772/intechopen.103896",abstract:"Since becoming a national user facility in 2007, the type of irradiation campaigns the Advanced Test Reactor (ATR) supports has become much more diverse and complex. In prior years, test complexity was limited by the computational ability to analyze the tests’ influence on the fuel. Large volume tests are irradiated in flux traps which are designed to receive excess neutrons from the surrounding fuel elements. Typically, fuel elements drive the test conditions, not vice versa. The computational tool, PDQ, was used for core physics analysis for decades. The PDQ code was adequate so long as the diffusion approximation between test and fuel element remained valid. This paradigm changed with the introduction of the Ki-Jang Research Reactor—Fuel Assembly Irradiation (KJRR-FAI) in 2015. The KJRR-FAI was a prototypic fuel element for the KJRR research reactor project in the Republic of Korea. The KJRR-FAI irradiation presented multiple modeling and simulation challenges for which PDQ was ill suited. To demonstrate that the KJRR-FAI could be irradiated and meet safety requirements, the modern neutron transport codes, HELIOS and MCNP, were extensively verified and validated to replace PDQ. The hybrid 3D/2D methodology devised with these codes made analysis of the ATR with KJRR-FAI possible. The KJRR-FAI was irradiated in 2015-2016.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Samuel E. Bays and Joseph W. Nielsen"},{id:"81555",title:"Nuclear Thermal Propulsion",slug:"nuclear-thermal-propulsion",totalDownloads:118,totalDimensionsCites:0,doi:"10.5772/intechopen.103895",abstract:"This chapter will cover the fundamentals of nuclear thermal propulsion systems, covering basic principles of operation and why nuclear is a superior option to chemical rockets for interplanetary travel. It will begin with a historical overview from early efforts in the early 1950s up to current interests, with respect to fuel types, core materials, and ongoing testing efforts. An overview will be provided of reactor types and design elements for reactor concepts or testing systems for nuclear thermal propulsion, followed by a discussion of nuclear thermal design concepts. A section on system design and modeling will be presented to discuss modeling and simulation of driving phenomena: neutronics, materials performance, heat transfer, and structural mechanics, solved in a tightly coupled multiphysics system. Finally, it will show the results of a coupled physics model for a conceptual design with simulation of rapid startup transients needed to maximize hydrogen efficiency.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Mark D. DeHart, Sebastian Schunert and Vincent M. Labouré"},{id:"81013",title:"Cyber-Informed Engineering for Nuclear Reactor Digital Instrumentation and Control",slug:"cyber-informed-engineering-for-nuclear-reactor-digital-instrumentation-and-control",totalDownloads:33,totalDimensionsCites:0,doi:"10.5772/intechopen.101807",abstract:"As nuclear reactors transition from analog to digital technology, the benefits of enhanced operational capabilities and improved efficiencies are potentially offset by cyber risks. Cyber-Informed Engineering (CIE) is an approach that can be used by engineers and staff to characterize and reduce new cyber risks in digital instrumentation and control systems. CIE provides guidance that can be applied throughout the entire systems engineering lifecycle, from conceptual design to decommissioning. In addition to outlining the use of CIE in nuclear reactor applications, this chapter provides a brief primer on nuclear reactor instrumentation and control and the associated cyber risks in existing light water reactors as well as the digital technology that will likely be used in future reactor designs and applications.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Shannon Eggers and Robert Anderson"},{id:"79671",title:"Fault Detection by Signal Reconstruction in Nuclear Power Plants",slug:"fault-detection-by-signal-reconstruction-in-nuclear-power-plants",totalDownloads:107,totalDimensionsCites:0,doi:"10.5772/intechopen.101276",abstract:"In this work, the recently developed auto associative bilateral kernel regression (AABKR) method for on-line condition monitoring of systems, structures, and components (SSCs) during transient process operation of a nuclear power plant (NPP) is improved. The advancement enhances the capability of reconstructing abnormal signals to the values expected in normal conditions during both transient and steady-state process operations. The modification introduced to the method is based on the adoption of two new approaches using dynamic time warping (DTW) for the identification of the time position index (the position of the nearest vector within the historical data vectors to the current on-line query measurement) used by the weighted-distance algorithm that captures temporal dependences in the data. Applications are provided to a steady-state numerical process and a case study concerning sensor signals collected from a reactor coolant system (RCS) during start-up operation of a NPP. The results demonstrate the effectiveness of the proposed method for fault detection during steady-state and transient operations.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Ibrahim Ahmed, Enrico Zio and Gyunyoung Heo"}],onlineFirstChaptersTotal:8},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:"2753-6580",scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
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\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
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\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. In 2017, Usha was awarded the Marquis Who’s Who Lifetime Achiever Award.",institutionString:null,institution:{name:"RMIT University",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!0,editor:{id:"205604",title:"Dr.",name:"Tomas",middleName:null,surname:"Jarzembowski",slug:"tomas-jarzembowski",fullName:"Tomas Jarzembowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKriQAG/Profile_Picture_2022-06-16T11:01:31.jpg",biography:"Tomasz Jarzembowski was born in 1968 in Gdansk, Poland. He obtained his Ph.D. degree in 2000 from the Medical University of Gdańsk (UG). After specialization in clinical microbiology in 2003, he started studying biofilm formation and antibiotic resistance at the single-cell level. In 2015, he obtained his D.Sc. degree. 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He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},{id:"6",title:"Viral Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",isOpenForSubmission:!0,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. 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Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. 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\r\n\tGlobally, the ecological footprint is growing at a faster rate than GDP. This phenomenon has been studied by scientists for many years. However, clear strategies and actions are needed now more than ever. Every day, humanity, from individuals to businesses (public and private) and governments, are called to change their mindset in order to pursue a virtuous combination for sustainable development. Reasoning in a sustainable way entails, first and foremost, managing the available resources efficiently and strategically, whether they are natural, financial, human or relational. In this way, value is generated by contributing to the growth, improvement and socio-economic development of the communities and of all the players that make up its value chain. In the coming decades, we will need to be able to transition from a society in which economic well-being and health are measured by the growth of production and material consumption, to a society in which we live better while consuming less. In this context, digitization has the potential to disrupt processes, with significant implications for the environment and sustainable development. There are numerous challenges associated with sustainability and digitization, the need to consider new business models capable of extracting value, data ownership and sharing and integration, as well as collaboration across the entire supply chain of a product. In order to generate value, effectively developing a complex system based on sustainability principles is a challenge that requires a deep commitment to both technological factors, such as data and platforms, and human dimensions, such as trust and collaboration. Regular study, research and implementation must be part of the road to sustainable solutions. Consequently, this topic will analyze growth models and techniques aimed at achieving intergenerational equity in terms of economic, social and environmental well-being. It will also cover various subjects, including risk assessment in the context of sustainable economy and a just society.
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