IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\n
By listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
All three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n
"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n
"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\n
In conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n
“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\n
We invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\n
Feel free to share this news on social media and help us mark this memorable moment!
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\n
By listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
All three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n
"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n
"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\n
In conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n
“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\n
We invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\n
Feel free to share this news on social media and help us mark this memorable moment!
\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"3348",leadTitle:null,fullTitle:"Tissue Engineering",title:"Tissue Engineering",subtitle:null,reviewType:"peer-reviewed",abstract:"The Tissue Engineering approach has major advantages over traditional organ transplantation and circumvents the problem of organ shortage. Tissues that closely match the patient’s needs can be reconstructed from readily available biopsies and subsequently be implanted with minimal or no immunogenicity. This eventually conquers several limitations encountered in tissue transplantation approaches.\r\nThis book serves as a good starting point for anyone interested in the application of Tissue Engineering. It offers a colorful mix of topics, which explain the obstacles and possible solutions for TE applications.",isbn:null,printIsbn:"978-953-307-079-7",pdfIsbn:"978-953-51-4553-0",doi:"10.5772/189",price:159,priceEur:175,priceUsd:205,slug:"tissue-engineering",numberOfPages:536,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"39bb39271df3b373edb7d5e2cdeffb18",bookSignature:"Daniel Eberli",publishedDate:"March 1st 2010",coverURL:"https://cdn.intechopen.com/books/images_new/3348.jpg",numberOfDownloads:122139,numberOfWosCitations:311,numberOfCrossrefCitations:101,numberOfCrossrefCitationsByBook:4,numberOfDimensionsCitations:292,numberOfDimensionsCitationsByBook:5,hasAltmetrics:1,numberOfTotalCitations:704,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 24th 2012",dateEndSecondStepPublish:"May 15th 2012",dateEndThirdStepPublish:"August 19th 2012",dateEndFourthStepPublish:"November 17th 2012",dateEndFifthStepPublish:"December 17th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,8",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"6495",title:"Dr.",name:"Daniel",middleName:null,surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli",profilePictureURL:"https://mts.intechopen.com/storage/users/6495/images/1947_n.jpg",biography:"Daniel Eberli MD. Ph.D. is a scientific physician working in the translational field of urologic tissue engineering. He has a medical degree from the Medical School in Zurich, Switzerland, and a Ph.D. in Molecular Medicine from Wake Forest University, Winston Salem, NC. He currently has a faculty position at the Department of Urology at the University Hospital Zurich, where he devotes half of his time to patient care. He is a lecturer at the Medical School of Zurich and the Swiss Federal Institute of Technology. Together with his research team, he is working on novel biomaterials for bladder reconstruction, improving autonomic innervation, cellular treatment of incontinence and tracking of stem cells.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"University Hospital of Zurich",institutionURL:null,country:{name:"Switzerland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"980",title:"Tissue Engineering and Regenerative Medicine",slug:"tissue-engineering-and-regenerative-medicine"}],chapters:[{id:"9809",title:"Development of Human Fetal Mesenchymal Stem Cell Mediated Tissue Engineering Bone Grafts",doi:"10.5772/8592",slug:"development-of-human-fetal-mesenchymal-stem-cell-mediated-tissue-engineering-bone-grafts",totalDownloads:3841,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Zhiyong Zhang, Swee-Hin Teoh, Mahesh Choolani and Jerry Chan",downloadPdfUrl:"/chapter/pdf-download/9809",previewPdfUrl:"/chapter/pdf-preview/9809",authors:[null],corrections:null},{id:"9806",title:"The Future of Cell Therapy and Tissue Engineering in Cardiovascular Disease: The New Era of Biological Therapeutics",doi:"10.5772/8589",slug:"the-future-of-cell-therapy-and-tissue-engineering-in-cardiovascular-disease-the-new-era-of-biologica",totalDownloads:3191,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Sepideh Heydarkhan-Hagvall, Ali Nsair, Ramin E. Beygui and Richard J. Shemin",downloadPdfUrl:"/chapter/pdf-download/9806",previewPdfUrl:"/chapter/pdf-preview/9806",authors:[null],corrections:null},{id:"9814",title:"Characteristics of Antlerogenic Stem Cells and Their Potential Application",doi:"10.5772/8597",slug:"characteristics-of-antlerogenic-stem-cells-and-their-potential-application",totalDownloads:3347,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Marek Cegielski, Ilona Iżykowska, Wojciech Dziewiszek, Maciej Zatonski, Marek Bochnia and Olga Kalisiak",downloadPdfUrl:"/chapter/pdf-download/9814",previewPdfUrl:"/chapter/pdf-preview/9814",authors:[null],corrections:null},{id:"9801",title:"Cell-Protein-Material Interaction in Tissue Engineering",doi:"10.5772/8584",slug:"cell-protein-material-interaction-in-tissue-engineering",totalDownloads:5422,totalCrossrefCites:3,totalDimensionsCites:17,hasAltmetrics:0,abstract:null,signatures:"Manuel Salmeron-Sanchez and George Altankov",downloadPdfUrl:"/chapter/pdf-download/9801",previewPdfUrl:"/chapter/pdf-preview/9801",authors:[null],corrections:null},{id:"9790",title:"Learning From Nature: Emulating Macromolecular Crowding To Drive Extracellular Matrix Enhancement For The Creation Of Connective Tissue in vitro",doi:"10.5772/8573",slug:"learning-from-nature-emulating-macromolecular-crowding-to-drive-extracellular-matrix-enhancement-for",totalDownloads:3319,totalCrossrefCites:1,totalDimensionsCites:6,hasAltmetrics:0,abstract:null,signatures:"Yanxian Peng and Michael Raghunath",downloadPdfUrl:"/chapter/pdf-download/9790",previewPdfUrl:"/chapter/pdf-preview/9790",authors:[null],corrections:null},{id:"9800",title:"Scaffolds for the Engineering of Functional Bladder Tissues",doi:"10.5772/8583",slug:"scaffolds-for-the-engineering-of-functional-bladder-tissues",totalDownloads:3416,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Horst Maya M.D., Srinivas Madduri Ph.D., Gobet Rita M.D., Sulser Tullio M.D., Heike Hall Ph.D. and Daniel Eberli M.D. Ph.D.",downloadPdfUrl:"/chapter/pdf-download/9800",previewPdfUrl:"/chapter/pdf-preview/9800",authors:[null],corrections:null},{id:"9798",title:"Biomaterial Scaffold Fabrication Techniques for Potential Tissue Engineering Applications",doi:"10.5772/8581",slug:"biomaterial-scaffold-fabrication-techniques-for-potential-tissue-engineering-applications",totalDownloads:14919,totalCrossrefCites:58,totalDimensionsCites:142,hasAltmetrics:0,abstract:null,signatures:"B. Subia, J. Kundu and S. C. Kundu",downloadPdfUrl:"/chapter/pdf-download/9798",previewPdfUrl:"/chapter/pdf-preview/9798",authors:[null],corrections:null},{id:"9812",title:"Electrospun Functional Nanofibrous Scaffolds for Tissue Engineering",doi:"10.5772/8595",slug:"electrospun-functional-nanofibrous-scaffolds-for-tissue-engineering",totalDownloads:4906,totalCrossrefCites:2,totalDimensionsCites:8,hasAltmetrics:0,abstract:null,signatures:"Xiaochuan Yang and Hongjun Wang",downloadPdfUrl:"/chapter/pdf-download/9812",previewPdfUrl:"/chapter/pdf-preview/9812",authors:[null],corrections:null},{id:"9791",title:"Selective Laser Sintering of Poly(L-Lactide)/Carbonated Hydroxyapatite Nanocomposite Porous Scaffolds for Bone Tissue Engineering",doi:"10.5772/8574",slug:"selective-laser-sintering-of-poly-l-lactide-carbonated-hydroxyapatite-nanocomposite-porous-scaffolds",totalDownloads:3186,totalCrossrefCites:3,totalDimensionsCites:19,hasAltmetrics:0,abstract:null,signatures:"Wen You Zhou, Min Wang, Wai Lam Cheung and Wing Yuk Ip",downloadPdfUrl:"/chapter/pdf-download/9791",previewPdfUrl:"/chapter/pdf-preview/9791",authors:[null],corrections:null},{id:"9810",title:"Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering",doi:"10.5772/8593",slug:"perspectives-of-chitin-and-chitosan-nanofibrous-scaffolds-in-tissue-engineering",totalDownloads:6129,totalCrossrefCites:6,totalDimensionsCites:10,hasAltmetrics:0,abstract:null,signatures:"R. Jayakumar, S. V. Nair, T. Furuike and H. Tamura",downloadPdfUrl:"/chapter/pdf-download/9810",previewPdfUrl:"/chapter/pdf-preview/9810",authors:[null],corrections:null},{id:"9797",title:"Bioresorbable Polymers for Tissue Engineering",doi:"10.5772/8580",slug:"bioresorbable-polymers-for-tissue-engineering",totalDownloads:3959,totalCrossrefCites:9,totalDimensionsCites:17,hasAltmetrics:0,abstract:null,signatures:"Arnaldo Rodrigues Santos Jr.",downloadPdfUrl:"/chapter/pdf-download/9797",previewPdfUrl:"/chapter/pdf-preview/9797",authors:[null],corrections:null},{id:"9804",title:"Physical Limitations to Tissue Engineering of Intervertabral Disc Cells",doi:"10.5772/8587",slug:"physical-limitations-to-tissue-engineering-of-intervertabral-disc-cells",totalDownloads:2469,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Shigeru Kobayashi, Hisatoshi Baba, Kenichi Takeno, Tsuyoshi Miyazaki, Adam Meir and Jill Urban",downloadPdfUrl:"/chapter/pdf-download/9804",previewPdfUrl:"/chapter/pdf-preview/9804",authors:[null],corrections:null},{id:"9803",title:"Enamel Tissue Engineering",doi:"10.5772/8586",slug:"enamel-tissue-engineering",totalDownloads:5173,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Masaki J. Honda and Ken-ichiro Hata",downloadPdfUrl:"/chapter/pdf-download/9803",previewPdfUrl:"/chapter/pdf-preview/9803",authors:[null],corrections:null},{id:"9792",title:"Design of Injectable Bone Tissue Engineering Scaffold Consists of ß-Tricalcium Phosphate Beads and Alginate",doi:"10.5772/8575",slug:"design-of-injectable-bone-tissue-engineering-scaffold-consists-of-tricalcium-phosphate-beads-and-alg",totalDownloads:4416,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Tomonori Matsuno",downloadPdfUrl:"/chapter/pdf-download/9792",previewPdfUrl:"/chapter/pdf-preview/9792",authors:[null],corrections:null},{id:"9813",title:"Low Intensity Pulsed Ultrasound: A Laboratory and Clinical Promoter in Tissue Engineering Abstract",doi:"10.5772/8596",slug:"low-intensity-pulsed-ultrasound-a-laboratory-and-clinical-promoter-in-tissue-engineering-abstract",totalDownloads:4336,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Tarek H. El-Bialy",downloadPdfUrl:"/chapter/pdf-download/9813",previewPdfUrl:"/chapter/pdf-preview/9813",authors:[null],corrections:null},{id:"9796",title:"Bioreactors in Tissue Engineering",doi:"10.5772/8579",slug:"bioreactors-in-tissue-engineering",totalDownloads:11171,totalCrossrefCites:3,totalDimensionsCites:27,hasAltmetrics:0,abstract:null,signatures:"S. Partap, N. A. Plunkett and F. J. O’Brien",downloadPdfUrl:"/chapter/pdf-download/9796",previewPdfUrl:"/chapter/pdf-preview/9796",authors:[null],corrections:null},{id:"9794",title:"High Resolution X-Ray Tomography - 3D Imaging for Tissue Engineering Applications",doi:"10.5772/8577",slug:"high-resolution-x-ray-tomography-3d-imaging-for-tissue-engineering-applications",totalDownloads:4245,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Zehbe Rolf, Haibel Astrid, Schmidt Franziska, Riesemeier Heinrich, Kirkpatrick C. James, Schubert Helmut and Brochhausen Christoph",downloadPdfUrl:"/chapter/pdf-download/9794",previewPdfUrl:"/chapter/pdf-preview/9794",authors:[null],corrections:null},{id:"9799",title:"In Vivo and In Vitro Models of Psoriasis",doi:"10.5772/8582",slug:"in-vivo-and-in-vitro-models-of-psoriasis",totalDownloads:9395,totalCrossrefCites:4,totalDimensionsCites:19,hasAltmetrics:0,abstract:null,signatures:"Jessica Jean and Roxane Pouliot",downloadPdfUrl:"/chapter/pdf-download/9799",previewPdfUrl:"/chapter/pdf-preview/9799",authors:[null],corrections:null},{id:"9807",title:"Growth Factors and Signalling Molecules for Cartilage Tissue Engineering – from Embryology to Innovative Release Strategies for Guided Tissue Engineering",doi:"10.5772/8590",slug:"growth-factors-and-signalling-molecules-for-cartilage-tissue-engineering-from-embryology-to-innovati",totalDownloads:4344,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Christoph Brochhausen, Rolf Zehbe, Bernhard Watzer, Sven Halstenberg, Helmut Schubert and C. James Kirkpatrick",downloadPdfUrl:"/chapter/pdf-download/9807",previewPdfUrl:"/chapter/pdf-preview/9807",authors:[null],corrections:null},{id:"9808",title:"Scaffold-free Cartilage Tissue by Mechanical Stress Loading for Tissue Engineering",doi:"10.5772/8591",slug:"scaffold-free-cartilage-tissue-by-mechanical-stress-loading-for-tissue-engineering",totalDownloads:3989,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Katsuko S Furukawa, Masato Sato, Toshihiro Nagai Stephanie Ting, Joji Mochida and Takashi Ushida",downloadPdfUrl:"/chapter/pdf-download/9808",previewPdfUrl:"/chapter/pdf-preview/9808",authors:[null],corrections:null},{id:"9795",title:"Tissue Engineering for Meniscus Regeneration",doi:"10.5772/8578",slug:"tissue-engineering-for-meniscus-regeneration",totalDownloads:3983,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Elizaveta Kon, Giuseppe Filardo, Marco Delcogliano, Giuseppe Peretti, Alessandro Di Martino and Maurilio Marcacci",downloadPdfUrl:"/chapter/pdf-download/9795",previewPdfUrl:"/chapter/pdf-preview/9795",authors:[null],corrections:null},{id:"9802",title:"Tissue Engineering of the Anterior Cruciate Ligament and Meniscus Using Acellularized Scaffolds",doi:"10.5772/8585",slug:"tissue-engineering-of-the-anterior-cruciate-ligament-and-meniscus-using-acellularized-scaffolds",totalDownloads:2852,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Gunther H. Sandmann and Thomas Tischer",downloadPdfUrl:"/chapter/pdf-download/9802",previewPdfUrl:"/chapter/pdf-preview/9802",authors:[null],corrections:null},{id:"9811",title:"Bio-nanotechnology Approaches to Neural Tissue Engineering",doi:"10.5772/8594",slug:"bio-nanotechnology-approaches-to-neural-tissue-engineering",totalDownloads:3954,totalCrossrefCites:3,totalDimensionsCites:7,hasAltmetrics:0,abstract:null,signatures:"Kun Zhou, David Nisbet, George Thouas, Claude Bernard and John Forsythe",downloadPdfUrl:"/chapter/pdf-download/9811",previewPdfUrl:"/chapter/pdf-preview/9811",authors:[null],corrections:null},{id:"9793",title:"Evolution in Tissue Engineering for the Lower Urinary Tract",doi:"10.5772/8576",slug:"evolution-in-tissue-engineering-for-the-lower-urinary-tract",totalDownloads:2721,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Bouhout Sara, Ouellet Gabrielle, Perron Emilie and Bolduc Stephane",downloadPdfUrl:"/chapter/pdf-download/9793",previewPdfUrl:"/chapter/pdf-preview/9793",authors:[null],corrections:null},{id:"9805",title:"Skin Substitutes",doi:"10.5772/8588",slug:"skin-substitutes",totalDownloads:3463,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Barbara Zavan, Vincenzo Vindigni, Roberta Cortivo and Giovanni Abatangelo",downloadPdfUrl:"/chapter/pdf-download/9805",previewPdfUrl:"/chapter/pdf-preview/9805",authors:[null],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"637",title:"Tissue Engineering for Tissue and Organ Regeneration",subtitle:null,isOpenForSubmission:!1,hash:"5bef0b1c31f0555294c7d49580c8d241",slug:"tissue-engineering-for-tissue-and-organ-regeneration",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/637.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4486",title:"Cells and Biomaterials in Regenerative Medicine",subtitle:null,isOpenForSubmission:!1,hash:"1c333e655d47208db36f2a886b49c160",slug:"cells-and-biomaterials-in-regenerative-medicine",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/4486.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3361",title:"Regenerative Medicine and Tissue Engineering",subtitle:null,isOpenForSubmission:!1,hash:"fe914d49a96b3dcd00d27292ae23536e",slug:"regenerative-medicine-and-tissue-engineering",bookSignature:"Jose A. Andrades",coverURL:"https://cdn.intechopen.com/books/images_new/3361.jpg",editedByType:"Edited by",editors:[{id:"40914",title:"Prof.",name:"Jose A.",surname:"Andrades",slug:"jose-a.-andrades",fullName:"Jose A. Andrades"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"786",title:"Advances in Regenerative Medicine",subtitle:null,isOpenForSubmission:!1,hash:"06d8a9addc021349418ffcc670142467",slug:"advances-in-regenerative-medicine",bookSignature:"Sabine Wislet-Gendebien",coverURL:"https://cdn.intechopen.com/books/images_new/786.jpg",editedByType:"Edited by",editors:[{id:"65329",title:"Dr.",name:"Sabine",surname:"Wislet",slug:"sabine-wislet",fullName:"Sabine Wislet"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"560",title:"Bone Regeneration",subtitle:null,isOpenForSubmission:!1,hash:"293cde681a800f168d0b3ceb13bac38a",slug:"bone-regeneration",bookSignature:"Haim Tal",coverURL:"https://cdn.intechopen.com/books/images_new/560.jpg",editedByType:"Edited by",editors:[{id:"97351",title:"Prof.",name:"Haim",surname:"Tal",slug:"haim-tal",fullName:"Haim Tal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6609",title:"Muscle Cell and Tissue",subtitle:"Current Status of Research Field",isOpenForSubmission:!1,hash:"522e700080f9e908b6b330587f0f381d",slug:"muscle-cell-and-tissue-current-status-of-research-field",bookSignature:"Kunihiro Sakuma",coverURL:"https://cdn.intechopen.com/books/images_new/6609.jpg",editedByType:"Edited by",editors:[{id:"195829",title:"Prof.",name:"Kunihiro",surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"824",title:"Tissue Regeneration",subtitle:"From Basic Biology to Clinical Application",isOpenForSubmission:!1,hash:"a7b540e4a2d901e0b3c940f69d0fc058",slug:"tissue-regeneration-from-basic-biology-to-clinical-application",bookSignature:"Jamie Davies",coverURL:"https://cdn.intechopen.com/books/images_new/824.jpg",editedByType:"Edited by",editors:[{id:"63994",title:"Prof.",name:"Jamie",surname:"Davies",slug:"jamie-davies",fullName:"Jamie Davies"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6475",title:"Tissue Regeneration",subtitle:null,isOpenForSubmission:!1,hash:"d5ed06a80f0205146aa90d158facefd1",slug:"tissue-regeneration",bookSignature:"Hussein Abdel hay El-Sayed Kaoud",coverURL:"https://cdn.intechopen.com/books/images_new/6475.jpg",editedByType:"Edited by",editors:[{id:"265070",title:"Dr.",name:"Hussein Abdelhay",surname:"Essayed Kaoud",slug:"hussein-abdelhay-essayed-kaoud",fullName:"Hussein Abdelhay Essayed Kaoud"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4610",title:"Muscle Cell and Tissue",subtitle:null,isOpenForSubmission:!1,hash:"f2719cb06d2a1327298528772eacec55",slug:"muscle-cell-and-tissue",bookSignature:"Kunihiro Sakuma",coverURL:"https://cdn.intechopen.com/books/images_new/4610.jpg",editedByType:"Edited by",editors:[{id:"173502",title:"Dr.",name:"Kunihiro",surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"79356",slug:"corrigendum-the-ghanaian-flora-as-a-potential-source-of-anthelmintic-and-anti-schistosomal-agents",title:"Corrigendum: The Ghanaian Flora as a Potential Source of Anthelmintic and Anti-Schistosomal Agents",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/76505.pdf\r\n",downloadPdfUrl:"/chapter/pdf-download/76505",previewPdfUrl:"/chapter/pdf-preview/76505",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/76505",risUrl:"/chapter/ris/76505",chapter:{id:"76353",slug:"the-ghanaian-flora-as-a-potential-source-of-anthelmintic-and-anti-schistosomal-agents",signatures:"Evelyn Asante-Kwatia, Abraham Yeboah Mensah, Lord Gyimah and Arnold Donkor Forkuo",dateSubmitted:"February 24th 2021",dateReviewed:"March 25th 2021",datePrePublished:"April 20th 2021",datePublished:"May 11th 2022",book:{id:"10356",title:"Natural Medicinal Plants",subtitle:null,fullTitle:"Natural Medicinal Plants",slug:"natural-medicinal-plants",publishedDate:"May 11th 2022",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"217045",title:"Dr.",name:"Arnold Forkuo",middleName:null,surname:"Donkor",fullName:"Arnold Forkuo Donkor",slug:"arnold-forkuo-donkor",email:"forkuo3@gmail.com",position:null,institution:{name:"Kwame Nkrumah University of Science and Technology",institutionURL:null,country:{name:"Ghana"}}},{id:"303360",title:"Dr.",name:"Evelyn",middleName:null,surname:"Asante-Kwatia",fullName:"Evelyn Asante-Kwatia",slug:"evelyn-asante-kwatia",email:"emireku@yahoo.com",position:null,institution:null},{id:"309974",title:"Prof.",name:"Abraham Yeboah",middleName:null,surname:"Mensah",fullName:"Abraham Yeboah Mensah",slug:"abraham-yeboah-mensah",email:"aymensah@yahoo.com",position:null,institution:{name:"Kwame Nkrumah University of Science and Technology",institutionURL:null,country:{name:"Ghana"}}},{id:"347910",title:"Mr.",name:"Lord",middleName:null,surname:"Gyimah",fullName:"Lord Gyimah",slug:"lord-gyimah",email:"lordgyimah36@gmail.com",position:null,institution:{name:"Kwame Nkrumah University of Science and Technology",institutionURL:null,country:{name:"Ghana"}}}]}},chapter:{id:"76353",slug:"the-ghanaian-flora-as-a-potential-source-of-anthelmintic-and-anti-schistosomal-agents",signatures:"Evelyn Asante-Kwatia, Abraham Yeboah Mensah, Lord Gyimah and Arnold Donkor Forkuo",dateSubmitted:"February 24th 2021",dateReviewed:"March 25th 2021",datePrePublished:"April 20th 2021",datePublished:"May 11th 2022",book:{id:"10356",title:"Natural Medicinal Plants",subtitle:null,fullTitle:"Natural Medicinal Plants",slug:"natural-medicinal-plants",publishedDate:"May 11th 2022",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"217045",title:"Dr.",name:"Arnold Forkuo",middleName:null,surname:"Donkor",fullName:"Arnold Forkuo Donkor",slug:"arnold-forkuo-donkor",email:"forkuo3@gmail.com",position:null,institution:{name:"Kwame Nkrumah University of Science and Technology",institutionURL:null,country:{name:"Ghana"}}},{id:"303360",title:"Dr.",name:"Evelyn",middleName:null,surname:"Asante-Kwatia",fullName:"Evelyn Asante-Kwatia",slug:"evelyn-asante-kwatia",email:"emireku@yahoo.com",position:null,institution:null},{id:"309974",title:"Prof.",name:"Abraham Yeboah",middleName:null,surname:"Mensah",fullName:"Abraham Yeboah Mensah",slug:"abraham-yeboah-mensah",email:"aymensah@yahoo.com",position:null,institution:{name:"Kwame Nkrumah University of Science and Technology",institutionURL:null,country:{name:"Ghana"}}},{id:"347910",title:"Mr.",name:"Lord",middleName:null,surname:"Gyimah",fullName:"Lord Gyimah",slug:"lord-gyimah",email:"lordgyimah36@gmail.com",position:null,institution:{name:"Kwame Nkrumah University of Science and Technology",institutionURL:null,country:{name:"Ghana"}}}]},book:{id:"10356",title:"Natural Medicinal Plants",subtitle:null,fullTitle:"Natural Medicinal Plants",slug:"natural-medicinal-plants",publishedDate:"May 11th 2022",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11433",leadTitle:null,title:"Human Migration in the Last Three Centuries",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tIn March 2022, another book on human migration seems important when the events or tragedies unfolding in Eastern Europe are considered. People have always migrated and have moved, but, specifically looking at the last three hundred years, involuntary migration is on the rise. Involuntary migration does not only affect Europe; Asia, Africa, and North as well as South America, have had their fair share of natural catastrophes, invasions, and wars. \r\n\tThis book will intend to look at different migrant patterns, voluntary and involuntary migration, over the last three centuries. What influenced people to leave their home countries, family, and friends and settle somewhere else? The book may include histories of the 19th century, consider tragedies and movements activated by political events in the 20th century, and/or look at recent events of the 21st century. Push and pull factors are important points. While most of us may be influenced in a negative way by the current happenings in Eastern Europe, the Russian invasion and resulting tragedies also demonstrate some very positive human traits – the preparedness of Ukraine’s surrounding countries to help those in need and to provide a safe place for the present. \r\n\tWhether one looks at voluntary or involuntary migration into any country, after a period of adjustment, migrants do play a positive role. The research found that migrants contribute to the economy (food, shelter, employment, tax) and enrich a country’s cultural norms. Prerequisites for successful settlements are that the host society adopts a tolerant approach and that the migrants recognize the law and the language of the host country. Nothing is ever easy or without controversy, but I am a migrant (German Australian), and life in Australia has been relatively harmonious. Issues that could be considered in the book are multicultural societies (do monocultural societies still exist?) and theories of acculturation versus integration (settlement processes). \r\n\tTwo further issues are very important in relation to human migration. There is climate change, global warming, and the environment, which clearly affect people’s movement. Small island populations are very concerned about rising sea levels. 2021 has also seen floods costing human lives: Turkey (August 2021), Brazil (December 2021), Chile (January 2021), and South India (November 2021), to name but a few. In Australia (March 2022), farms and whole townships in New South Wales and Queensland have been flooded for the second time in five years, and plans to resettle these towns are considered. Official and social media provide ample coverage of the events, which leads me to the next issue. There is today’s very important role of the media, of the official and social media. We are constantly bombarded with images of human war tragedies and flood victims. People in industrialized, western countries must be the best-informed populace. How far do the images and up-to-date TV news influence us, make us change our behavior, and perhaps even consider us more generous than we have been? \r\n\tClimate change and the media are relatively new to the human migration debate, but both issues play important parts, and some interesting discussions are appreciated. \r\n\t
",isbn:"978-1-80356-618-4",printIsbn:"978-1-80356-617-7",pdfIsbn:"978-1-80356-619-1",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"9836df9e82aa9f82e3852a60204909a8",bookSignature:"Dr. Ingrid Muenstermann",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11433.jpg",keywords:"Voluntary Migration, Involuntary Migration, Push Factors, Pull Factors, Receiving Countries, Human Rights Violations, Migrants' Acculturation, Migrants' Integration, Young People's Movement, Climate Change, War, Psychological Consequences",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 13th 2022",dateEndSecondStepPublish:"July 13th 2022",dateEndThirdStepPublish:"September 11th 2022",dateEndFourthStepPublish:"November 30th 2022",dateEndFifthStepPublish:"January 29th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Ingrid Muenstermann is a Casual Academic at the College of Nursing and Health Sciences, Flinders University of South Australia, with a rich research background in relation to migration. For many years she worked as a secretary in the medical field. Still, she discovered the rewards of becoming an academic after achieving a Ph.D. in Social Sciences (Flinders University, Ph.D. supervisor Prof Robert Holton).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"77112",title:"Dr.",name:"Ingrid",middleName:null,surname:"Muenstermann",slug:"ingrid-muenstermann",fullName:"Ingrid Muenstermann",profilePictureURL:"https://mts.intechopen.com/storage/users/77112/images/system/77112.jpg",biography:"Ingrid Muenstermann was born in 1938 in Hamburg, Germany, and settled in Australia in 1973. For many years she worked as a secretary in the medical field, but discovered the rewards of becoming an academic after achieving a PhD in Social Sciences. She is a sociologist at heart and is casually employed at Flinders University of South Australia. Dr. Muenstermann has a special interest in all things equity. Of particular interest have been, and still are, new settlers to Australia with a special focus on German immigrants. The decline of the natural environment and increased societal self-interest led her to consider universal social responsibility. Lately the concept of aging and how to retire gracefully, that is, to maintain a certain standard of living, have been on her mind. She hopes to research different areas of life in the not too distant future.",institutionString:"Flinders University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Flinders University",institutionURL:null,country:{name:"Australia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"23",title:"Social Sciences",slug:"social-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"466997",firstName:"Patricia",lastName:"Kerep",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/466997/images/21565_n.jpg",email:"patricia@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully"}},relatedBooks:[{type:"book",id:"5598",title:"People's Movements in the 21st Century",subtitle:"Risks, Challenges and Benefits",isOpenForSubmission:!1,hash:"34b65e63d50ff8998006a76b46081adf",slug:"people-s-movements-in-the-21st-century-risks-challenges-and-benefits",bookSignature:"Ingrid Muenstermann",coverURL:"https://cdn.intechopen.com/books/images_new/5598.jpg",editedByType:"Edited by",editors:[{id:"77112",title:"Dr.",name:"Ingrid",surname:"Muenstermann",slug:"ingrid-muenstermann",fullName:"Ingrid Muenstermann"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6630",title:"Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"2f6cc315119ed59e44cce41a717d6316",slug:"social-responsibility",bookSignature:"Ingrid Muenstermann",coverURL:"https://cdn.intechopen.com/books/images_new/6630.jpg",editedByType:"Edited by",editors:[{id:"77112",title:"Dr.",name:"Ingrid",surname:"Muenstermann",slug:"ingrid-muenstermann",fullName:"Ingrid Muenstermann"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8090",title:"Who Wants to Retire and Who Can Afford to Retire?",subtitle:null,isOpenForSubmission:!1,hash:"90fe30d224594414bb156e42afa47f5e",slug:"who-wants-to-retire-and-who-can-afford-to-retire-",bookSignature:"Ingrid Muenstermann",coverURL:"https://cdn.intechopen.com/books/images_new/8090.jpg",editedByType:"Edited by",editors:[{id:"77112",title:"Dr.",name:"Ingrid",surname:"Muenstermann",slug:"ingrid-muenstermann",fullName:"Ingrid Muenstermann"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6942",title:"Global Social Work",subtitle:"Cutting Edge Issues and Critical Reflections",isOpenForSubmission:!1,hash:"222c8a66edfc7a4a6537af7565bcb3de",slug:"global-social-work-cutting-edge-issues-and-critical-reflections",bookSignature:"Bala Raju Nikku",coverURL:"https://cdn.intechopen.com/books/images_new/6942.jpg",editedByType:"Edited by",editors:[{id:"263576",title:"Dr.",name:"Bala",surname:"Nikku",slug:"bala-nikku",fullName:"Bala Nikku"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6926",title:"Biological Anthropology",subtitle:"Applications and Case Studies",isOpenForSubmission:!1,hash:"5bbb192dffd37a257febf4acfde73bb8",slug:"biological-anthropology-applications-and-case-studies",bookSignature:"Alessio Vovlas",coverURL:"https://cdn.intechopen.com/books/images_new/6926.jpg",editedByType:"Edited by",editors:[{id:"313084",title:"Dr.",name:"Alessio",surname:"Vovlas",slug:"alessio-vovlas",fullName:"Alessio Vovlas"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"65878",title:"Vitamin K2: A Vitamin that Works like a Hormone, Impinging on Gene Expression",doi:"10.5772/intechopen.80388",slug:"vitamin-k2-a-vitamin-that-works-like-a-hormone-impinging-on-gene-expression",body:'
1. Introduction
Vitamin K has since more than 25 years been known to serve as a powerful nutrient factor in the preservation of homeostatic bone turnover, along with blood clotting biochemistry. In addition, vitamin K has been used as a therapeutic remedy in the clinic to treat and prevent bone brittleness (osteoporosis) in Japan and many other countries around the world. Moreover, beyond its enzymatic character as a cofactor for the vitamin K-dependent GGCX (gamma-glutamyl carboxylase), Professor Inoue and his co-workers have shown that the K2 variant is, in fact, a transcriptional modulator of osseous marker genes, also serving as an extracellular matrix-related molecule, via the stimulation of the ‘steroid and xenobiotic receptor’ SXR [1]. A microarray-based revelation of the present action of vitamin K2 in bone-derived osteoblastic cell genes corroborated the notion that the K2 variant menaquinone-4 (MK-4), in fact, is a hormone. Among the significantly upregulated genes, both growth differentiation factor 15 (GDF15) and stanniocalcin 2 (STC2) were concluded to serve as novel target genes, which both circumvented the traditional GGCX- and SXR-mediated pathways found in osteoblast-like cells.
2. Vitamin K2: vitamin and hormone
The induction of both GDF15 and STC2 genes is construed as specific to MK-4, since it was shown not to be brought about by another vitamin K(2) isoform MK-7, vitamin K(1) or the MK-4 side chain containing the geranylgeraniol group. A survey into the signalling pathways in question indicated that MK-4 sustained phosphorylation of protein kinase A (PKA) and that MK-4 mediated upregulation of genes, such as GDF15 and STC2, was diminished by the exposure to a PKA inhibitor or by siRNA constructs against PKA. These observations were in line with the concept that vitamin K(2) was capable of modulating its own target gene expression in bone-derived (osteoblastic) cell entities through a PKA-driven pathway, which in essence was different from the traditional vitamin K-dependent signalling pathways [2].
Vitamin K2 has been included as a member in a group of molecules, constituting the ‘requirement’ for blood to coagulate; however, it has been demonstrated to function or serve as a key in the homeostasis of osseous tissue, thus showing effectiveness as one therapeutic agent, among others, in the curative treatment portfolio of bone ailments and diseases, i.e. like bone loss or brittleness (osteomalacia and osteoporosis). Furthermore, it has, since several decades, been acknowledged that vitamin K2 mediates transcriptional modulation of marker genes in osteoblastic cells, as well as reinforcing bone formation via the nuclear steroid and xenobiotic receptor, SXR. In this context, Dr. Satoshi Inoue and his research team identified several genes, which were upregulated by vitamin K2 (and a prototypical SXR like ligand, rifampicin) in osteoblastic cells, through microarray analysis and PCR. A plethora of genes was upregulated, among which collagen synthesis and accumulation in osteoblast-like MG63 cells were enhanced several times over by vitamin K2 treatment. Therefore, the results of Dr. Inoue and his research group more than suggested a novel function for vitamin K2 in the formation of osseous tissues, i.e. that K2 was a true transcriptional regulator of extracellular matrix-related genes, being involved in the assembly of collagen. At present, we know that vitamin K2 (or menaquinone-7 = MK-7, among other vitamin K2 metabolites) works through this nuclear receptor and consequently should be classified as a hormone and not solely be construed as ‘a vitamin’.
Arterial stiffness is always associated with an enhanced cardiovascular risk, morbidity and mortality [3]. The present article reviews the main vitamins being involved in arterial stiffness and enabling destiffening; their mechanism of action, providing a brief description of the latest studies in the area; and their implications for primary cardiovascular prevention, clinical practice and therapy. Despite inconsistent proof for ‘softening’ brought about by vitamin supplementation in a plethora of clinical trials, promising results were observed in selected populations. The chief mechanisms pertain to anti-atherogenic potential, substantial augmentation of endothelial functionality (pertaining to vitamins A, C, D and E, respectively) and general metabolic profiling (pertaining to vitamins A, B12, C, D and K, respectively), suppression of the renin-angiotensin-aldosterone (R-R-A) system (vitamin D), anti-inflammatory (vitamins A-D-E-K) and antioxidant effects (vitamins A-C-E), diminished homocysteine levels (vitamin B12) and a reversal of the calcification of arteries (vitamin K). Vitamins A, B12, C, D and E, as well as vitamin K status, are important in evaluating the risk of cardiovascular events, and, finally, supplementation with vitamins may serve as an efficient, individually based and less costly ‘destiffening’ therapeutic mode.
Vitamin K is renowned for being an important (vital) nutrient, sustaining both bone homeostasis and blood coagulation. Therefore, it is both clinically and ubiquitously used as a therapeutic agent or treatment for osteoporosis in Japan and western countries. Besides its powerful enzymatic, cofactor role of the vitamin K-dependent g-glutamyl carboxylase (GGCX), it has since long been known that vitamin K2 may serve as a transcriptional regulator of marker osteoblastic genes, as well as in matrix-related, extracellular genes. In this context the activation of the so-called steroid and xenobiotic receptor (known as SXR) is mandatory.
Hence, genes known to be upregulated by vitamin K2 isoforms like menaquinone-4 (MK-4) were applied using oligonucleotide-based microarray analyses. Among the MK-4 upregulated gene species, the growth differentiation factor 15 (GDF15) and stanniocalcin 2 (STC2) were discovered as new MK-4 target genes, being independent of the GGCX and SXR pathways in osteoblastic cells. The observed induction of GDF15 and STC2 was construed as specific to MK-4, since it was not seen with exposure to MK-7 or vitamin K1. Surprisingly, a scrutiny of the main signalling pathways showed that MK-4 stimulated PKA (protein kinase A) phosphorylation. Furthermore, the MK-4-dependent induction of both GDF15 and STC2 genes was obliterated subsequent to the treatment with PKA inhibitors or siRNAs against PKA. Therefore, it was postulated that vitamin K2 (MK-7) could modulate target gene expression in osteoblastic cells via PKA-dependent mechanisms, which were distinct from any previously known vitamin K-mediated signalling pathway.
The paper found that vitamin K2 is recognised, along with calcium, vitamin D and magnesium, as essential in supporting strong bones and healthy arteries. In the paper, Nutritional strategies for skeletal and cardiovascular health: hard bones, soft arteries, rather than vice versa, the authors cite a US Surgeon General’s Report that states that one in two Americans over 50 is expected to have or to be at risk of developing osteoporosis, which causes 8.9 million fractures annually, with an estimated cumulative cost of incident fractures predicted at $474 billion during the next 20 years in the USA.
Furthermore, a study conducted by the Mayo Clinic [4, 5] reported that ‘compared with 30 years ago, forearm fractures have risen more than 32% in boys and 56% in girls’. Meanwhile, strong epidemiological associations exist between decreased bone mineral density (BMD) and increased risk of cardiovascular (CV) disease. For example, individuals with osteoporosis have a higher risk of coronary artery disease and vice versa. This problem will be magnified, according to the paper, if the therapies for osteoporosis (calcium supplements) independently increase risk of myocardial infarction. To that end, the authors conducted a comprehensive and systematic review of the scientific literature to determine the optimal dietary strategies and nutritional supplements for long-term skeletal health and cardiovascular health. They summarised what is helpful for building strong bones while maintaining soft and supple arteries:
Obtain calcium from dietary sources (the best choice is a calcium hydroxyapatite) with the adequate animal protein, fruit and vegetable intake.
Concomitantly increase potassium consumption, while reducing sodium intake should be taken into account.
Maintain vitamin D levels in the normal range.
Increase the intake of foods rich in vitamins K1 and K2.
The study notes: ‘A meta-analysis concluded that while supplementation with phytonadione (vitamin K1) improved bone health, vitamin K2 was even more effective in this regard. This large and statistically rigorous meta-analysis concluded that high vitamin K2 levels were associated with reduced vertebral fractures by approximately 60%, hip fractures by 77% and all non-vertebral fractures by approximately 81%. Supplementation with vitamin K2 as MK-7 increased bone strength in postmenopausal women in 3-year clinical study’.
‘Additionally, increased vitamin K2 intake has been associated with decreased arterial calcium deposition and the ability to reverse vascular calcification in animal models. Moreover clinical trial proved that vitamin K2 supplementation increases elasticity of the arteries (in 3 years)’, the paper stated. The authors recommend increasing the intake of foods rich in vitamins K1 and K2 to secure skeletal and cardiovascular health. ‘The positive health potential of vitamin K2 is more effective than for vitamin K1, the paper reads. Yet, Dr. Hogne Vik, Chief Medical Officer with NattoPharma, world leader in vitamin K2 R&D, exclusive global supplier of MenaQ7 vitamin K2 as MK-7, and sponsor of the 3-year studies cited in the paper, explains that it is not possible to get sufficient amounts of vitamin K2 through a European or US diet’.
The only food that contains enough vitamin K2 is the Japanese dish Natto. ‘This means that if you want to get enough vitamin K2 into your body, then you have to take dietary supplements or functional foods containing vitamin K2’, he said. ‘We are gratified, but not surprised, that our 3-year clinical studies were cited in this paper’, Dr. Vik continues. ‘NattoPharma has driven the clinical research that has demonstrated vitamin K2’s benefits for human health, and our breakthrough studies provided the first intervention data confirming the associations that observational studies made previously: that vitamin K2 as MK-7 is available beyond the liver to support bone and cardiovascular health. And it does this by activating proteins that help the body to properly utilise calcium – there by simultaneously supporting both skeletal and cardiovascular health’.
How are we going to interpret the above-described information about the mechanism of action of vitamin K2? Well, according to the definition given in dictionaries and scientific papers, vitamin K2 (as in the form or MK-4 or MK-7) fits this definition and should be classified as one.
3. What features characterise a true hormone?
To make the picture clearer, let us start all over again. According to Figure 1, the impact of a hormone is one signal among differentiation signals (also called epigenator factors), which may be temperature variations, oxygen tension, mechano-stimulation or humoral factor/hormones. The ‘hormone’ eventually activates a transcription factor or microRNA synthesis, which may impinge upon DNA in terms of a certain or given spectrum of mRNAs appearing in the cytosol of the cell. Of major interest here are eventually two classes of molecules utmost important for the acquisition of the final cell phenotype—the histones and the sirtuins (see Figure 5).
Figure 1.
The epigenator-initiator-maintainer model of hormonal impact on the phenotype of a given cell. The hormone (binding to a given receptor—here represented by two different transmembrane proteins) will eventually elicit a response determined by the joint effect of transcription factors and microRNAs determining the end-point effect of the epigenator, such as cell differentiation and/or efflux of secretory products.
The response elicited by a single hormone (epigenator) may look like the network of interacting factors (mostly transcription factors), such as the network representing the closely cooperating network (mostly represented by transcription factor), as seen in Figure 2a and b.
Figure 2.
(a) and (b) GeneCards-based emulation of molecules interacting with NR1/NR2 (which is identical to SXR, identified/described by the Japanese researcher, Professor Satoshi Inoue). Interestingly, NR1/NR2 is integrated in a large network of interacting molecules (genes), representing various classes of transcription factors (e.g. PPARG, RORC, RARA, RXR) and not to forget the thyroid receptors A and B!
The reader is recommended to look up the remainder of the genes shown above and will be amazed as to the plethora of biological effects being modulated (directly and/or indirectly) by the nuclear receptor NR1/NR2 = SXR, to which vitamin K2 binds, exerting its multitude of biological effects. The crucial question is then: what may be the immediate effect of vitamin K2 (e.g. MK-7) on cell phenotype, for example, on bone chips harbouring live osteoblastic cells? In Figure 3, bovine chips from young calves were incubated for 14 days in growth medium, which were analysed for osteocalcin, IL-10, TGFβ, OPG and RANKL (osteoblast and osteoclast markers), respectively. For detailed summary of results, see Figure 3.
Figure 3.
Bovine chips from young calves incubated as stated above. The chips were (a) incubated for 7 or 21 days and analysed for osteocalcin, IL-10, TGFβ, OPG and RANKL (all parameters’ characteristics for the osteoblast phenotype); (b) incubated for 7 days and thereafter for 14 days in the presence of either vitamin K2 = MK-7; siRNA against the vitamin K2 receptor SXR or with pre-mir-760. The final measurements of secretory products were as indicated above (osteocalcin, IL-10, TGFβ, OPG and RANKL).
The interpretation of the experiment with ‘live’ bovine bone chips is the following: since MK-7 (a vitamin K2 analogue) is stimulated, while SXR siRNA and pre-mir-760 markedly reduced the secretory profile of the bovine osteoblast, it was concluded that the effect of vitamin K2 (MK-7) on the osteoblast profile of secretory molecules was stimulatory and that the effect of vitamin K2 was mediated solely through the action of the nuclear receptor SXR.
Furthermore, it was shown that one well-known and well-represented vitamin K2 ‘analogue’ (MK-7) was able to activate (upregulate) some of the members of the FoxA and FoxO family of transcription factors. In our hands, vitamin K2 analogue MK-7 (and to a lesser extent MK-4) was able to substitute for insulin, as well as some growth factors (like growth hormone and a few interleukins (not shown)) (Figure 4).
Figure 4.
The impact of insulin and growth factors (GFs) on members of the FoxA and FoxO families of insulin and growth factors.
Figure 5 shows a strong relationship (network between a human osteoblast microRNA profile, respectively, and a well-known plethora of marker genes) which has previously been listed according to their sequential appearance as the osteoblast develops from a stem cell into a ‘full-blown’, mature mineralizing osteoblast. By adding a plethora of transcription factors, sirtuins (SIRTs), histone deacetylases (HDACs) and transcription factors (with special references to the osteoblastic phenotype), a distinct pattern of interaction appeared. By adding vitamin K2, i.e. MK-7 and/or SXR, to the system, a similar pattern appeared (not shown1). This was also the case for other tissues as well, e.g. lung, heart, brain, muscle, white/beige fat tissues and many others (not mentioned here2).
Figure 5.
Network (based on the computerprogram Mir@nt@n) postulating the interaction between key microRNAs, transcription factors, sirtuins, and histone deacetylases (HDACs) in the developing osteoblast from stem cells via preosteoblasts. The compilation of genes was based on various searches on PubMed for genes appearing during the course of preosteoblast to mature (mineralizing) osteoblasts from mammalian species, including humans.
\n',keywords:"vitamin K2, SXR, G-proteins, vitamin A-D-K2 cascade, bioinformatics, in vitro model systems",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/65878.pdf",chapterXML:"https://mts.intechopen.com/source/xml/65878.xml",downloadPdfUrl:"/chapter/pdf-download/65878",previewPdfUrl:"/chapter/pdf-preview/65878",totalDownloads:1918,totalViews:989,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:16,introChapter:null,impactScore:0,impactScorePercentile:42,impactScoreQuartile:2,hasAltmetrics:1,dateSubmitted:"April 14th 2018",dateReviewed:"July 18th 2018",datePrePublished:null,datePublished:"April 17th 2019",dateFinished:"February 25th 2019",readingETA:"0",abstract:"Vitamin K2 binds to the intranuclear receptor SXR and results in the activation of a plethora of genes, both directly and indirectly. Among these genes are important biological markers of cellular characteristics or features (also known as cell phenotypes), as well as a set of molecules known to be involved in both hormone-induced, G-protein-mediated cell signalling, either directly or indirectly activating so-called sirtuins and/or histone deacetylaces (HDACs), known as determinants of cell types and their specific functions in a given tissue. Hence, vitamin K2 may be closely involved in or serving as a traditional molecular ‘link’ between hormonal receptors and intracellular signalling pathways. It has been stated that a true hormone is a product of living cells, which circulates in body fluids (such as blood) and elicits a specific and often stimulatory effect on the activity of cells situated remotely from its point of origin. A large bulk of evidence published over the past 10 years establishes vitamin K2 in this category of substances. Hence, vitamin K2 should be considered and consequently classified as a hormone.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/65878",risUrl:"/chapter/ris/65878",book:{id:"6883",slug:"cell-signalling-thermodynamics-and-molecular-control"},signatures:"Jan Oxholm Gordeladze",authors:[{id:"36345",title:"Prof.",name:"Jan",middleName:"Oxholm",surname:"Gordeladze",fullName:"Jan Gordeladze",slug:"jan-gordeladze",email:"j.o.gordeladze@medisin.uio.no",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/36345/images/3823_n.jpg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Vitamin K2: vitamin and hormone",level:"1"},{id:"sec_3",title:"3. What features characterise a true hormone?",level:"1"}],chapterReferences:[{id:"B1",body:'Sultana H, Watanabe K, Md MR, Takashima R, Ai O, Komai M, et al. Effects of Vitamin K2 on the Expression of Genes Involved in Bile Acid Synthesis and Glucose Homeostasis in Mice with Humanized PXR. Sendai, Japan: Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University. 2018'},{id:"B2",body:'Ichikawa T, Horie-Inoue K, Ikeda K, Blumberg B, Inoue S. Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. Journal of Molecular Endocrinology. 2007;39(4):239-247'},{id:"B3",body:'Mosos I. Review article—Crosstalk between vitamins A, B12, D, K, C, and E status and arterial stiffness. Disease Markers. 2017;2017:14. Article ID: 8784971. DOI: 10.1155/2017/8784971'},{id:"B4",body:'https://www.bodyscience.com.au/blog/dr-hogne-vik-vitamin-k2-interview/'},{id:"B5",body:'Gordeladze JO. General Reading on Vitamin K2: Vitamin K2—Vital for Health and Well-Being. IntechOpen. 2017. DOI: 10.5772/61430'}],footnotes:[{id:"fn1",explanation:"Details not included—patents pending."},{id:"fn2",explanation:"Details not included—patents pending."}],contributors:[{corresp:"yes",contributorFullName:"Jan Oxholm Gordeladze",address:"j.o.gordeladze@medisin.uio.no",affiliation:'
Department of Molecular Medicine, Section for Biochemistry, Institute of Basic Medical Science, Blindern, Norway
'}],corrections:null},book:{id:"6883",type:"book",title:"Cell Signalling",subtitle:"Thermodynamics and Molecular Control",fullTitle:"Cell Signalling - Thermodynamics and Molecular Control",slug:"cell-signalling-thermodynamics-and-molecular-control",publishedDate:"April 17th 2019",bookSignature:"Sajal Ray",coverURL:"https://cdn.intechopen.com/books/images_new/6883.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83880-066-6",printIsbn:"978-1-83880-065-9",pdfIsbn:"978-1-83962-133-8",reviewType:"peer-reviewed",numberOfWosCitations:3,isAvailableForWebshopOrdering:!0,editors:[{id:"173697",title:"Prof.",name:"Sajal",middleName:null,surname:"Ray",slug:"sajal-ray",fullName:"Sajal Ray"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"47"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"62976",type:"chapter",title:"Information Thermodynamics of Cell Signal Transduction",slug:"information-thermodynamics-of-cell-signal-transduction",totalDownloads:1057,totalCrossrefCites:0,signatures:"Tatsuaki Tsuruyama",reviewType:"peer-reviewed",authors:[{id:"94907",title:"Prof.",name:"Tatsuaki",middleName:null,surname:"Tsuruyama",fullName:"Tatsuaki Tsuruyama",slug:"tatsuaki-tsuruyama"}]},{id:"64232",type:"chapter",title:"Wnt Signaling as a Master Regulator of Immune Tolerance in a Tumor Microenvironment",slug:"wnt-signaling-as-a-master-regulator-of-immune-tolerance-in-a-tumor-microenvironment",totalDownloads:1230,totalCrossrefCites:2,signatures:"María Cristina Castañeda-Patlán, Gabriela Fuentes-García and\nMartha Robles-Flores",reviewType:"peer-reviewed",authors:[{id:"140473",title:"Dr.",name:"Martha",middleName:null,surname:"Robles-Flores",fullName:"Martha Robles-Flores",slug:"martha-robles-flores"},{id:"142831",title:"Dr.",name:"Maria Cristina",middleName:null,surname:"Castañeda-Patlán",fullName:"Maria Cristina Castañeda-Patlán",slug:"maria-cristina-castaneda-patlan"},{id:"273066",title:"MSc.",name:"Gabriela",middleName:null,surname:"Fuentes",fullName:"Gabriela Fuentes",slug:"gabriela-fuentes"}]},{id:"62003",type:"chapter",title:"A Novel Genetic Circuit Supports Laboratory Automation and High Throughput Monitoring of Inflammation in Living Human Cells",slug:"a-novel-genetic-circuit-supports-laboratory-automation-and-high-throughput-monitoring-of-inflammatio",totalDownloads:967,totalCrossrefCites:0,signatures:"Natalie Duong, Kevin Curley, Mai Anh Do, Daniel Levy and Biao Lu",reviewType:"peer-reviewed",authors:[{id:"176226",title:"Dr.",name:"Biao",middleName:null,surname:"Lu",fullName:"Biao Lu",slug:"biao-lu"},{id:"255096",title:"Ms.",name:"Natalie",middleName:null,surname:"Duong",fullName:"Natalie Duong",slug:"natalie-duong"},{id:"255097",title:"Mr.",name:"Kevin",middleName:null,surname:"Curley",fullName:"Kevin Curley",slug:"kevin-curley"},{id:"255098",title:"Ms.",name:"Mai",middleName:null,surname:"Do",fullName:"Mai Do",slug:"mai-do"},{id:"255099",title:"Mr.",name:"Daniel",middleName:null,surname:"Levy",fullName:"Daniel Levy",slug:"daniel-levy"}]},{id:"64571",type:"chapter",title:"The Signaling Nature of Cellular Metabolism: The Hypoxia Signaling",slug:"the-signaling-nature-of-cellular-metabolism-the-hypoxia-signaling",totalDownloads:1215,totalCrossrefCites:0,signatures:"Zsolt Fabian",reviewType:"peer-reviewed",authors:[{id:"253695",title:"Ph.D.",name:"Zsolt",middleName:null,surname:"Fabian",fullName:"Zsolt Fabian",slug:"zsolt-fabian"}]},{id:"65878",type:"chapter",title:"Vitamin K2: A Vitamin that Works like a Hormone, Impinging on Gene Expression",slug:"vitamin-k2-a-vitamin-that-works-like-a-hormone-impinging-on-gene-expression",totalDownloads:1918,totalCrossrefCites:0,signatures:"Jan Oxholm Gordeladze",reviewType:"peer-reviewed",authors:[{id:"36345",title:"Prof.",name:"Jan",middleName:"Oxholm",surname:"Gordeladze",fullName:"Jan Gordeladze",slug:"jan-gordeladze"}]}]},relatedBooks:[{type:"book",id:"5899",title:"Organismal and Molecular Malacology",subtitle:null,isOpenForSubmission:!1,hash:"a7f042a23fd6991a546812db126ef875",slug:"organismal-and-molecular-malacology",bookSignature:"Sajal Ray",coverURL:"https://cdn.intechopen.com/books/images_new/5899.jpg",editedByType:"Edited by",editors:[{id:"173697",title:"Prof.",name:"Sajal",surname:"Ray",slug:"sajal-ray",fullName:"Sajal Ray"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"54857",title:"Ecology, Fishery and Aquaculture in Gulf of California, Mexico: Pen Shell Atrina maura (Sowerby, 1835)",slug:"ecology-fishery-and-aquaculture-in-gulf-of-california-mexico-pen-shell-atrina-maura-sowerby-1835-",signatures:"Ruth Escamilla-Montes, Genaro Diarte-Plata, Antonio Luna-\nGonzález, Jesús Arturo Fierro-Coronado, Héctor Manuel Esparza-\nLeal, Salvador Granados-Alcantar and César Arturo Ruiz-Verdugo",authors:[{id:"198991",title:"Dr.",name:"Genaro",middleName:null,surname:"Diarte-Plata",fullName:"Genaro Diarte-Plata",slug:"genaro-diarte-plata"},{id:"199061",title:"Dr.",name:"Ruth",middleName:null,surname:"Escamilla-Montes",fullName:"Ruth Escamilla-Montes",slug:"ruth-escamilla-montes"},{id:"199062",title:"Dr.",name:"Antonio",middleName:null,surname:"Luna-González",fullName:"Antonio Luna-González",slug:"antonio-luna-gonzalez"},{id:"199065",title:"MSc.",name:"Jesús Arturo",middleName:null,surname:"Fierro-Coronado",fullName:"Jesús Arturo Fierro-Coronado",slug:"jesus-arturo-fierro-coronado"},{id:"199067",title:"Dr.",name:"Héctor Manuel",middleName:null,surname:"Esparza-Leal",fullName:"Héctor Manuel Esparza-Leal",slug:"hector-manuel-esparza-leal"},{id:"199080",title:"Dr.",name:"César Arturo",middleName:null,surname:"Ruíz-Verdugo",fullName:"César Arturo Ruíz-Verdugo",slug:"cesar-arturo-ruiz-verdugo"},{id:"205357",title:"Dr.",name:"Salvador",middleName:null,surname:"Granados-Alcantar",fullName:"Salvador Granados-Alcantar",slug:"salvador-granados-alcantar"}]},{id:"54544",title:"Possible Poecilogony Due to Discontinuous Multifactorial Inheritance in Some Mediterranean Species of Raphitoma (Mollusca, Conoidea, Raphitomidae)",slug:"possible-poecilogony-due-to-discontinuous-multifactorial-inheritance-in-some-mediterranean-species-o",signatures:"Thanasis Manousis, Constantinos Kontadakis, George Mbazios,\nGeorgios Polyzoulis and Sofia Galinou-Mitsoudi",authors:[{id:"85155",title:"Dr.",name:"Sofia",middleName:null,surname:"Galinou-Mitsoudi",fullName:"Sofia Galinou-Mitsoudi",slug:"sofia-galinou-mitsoudi"},{id:"199094",title:"Dr.",name:"Thanasis",middleName:null,surname:"Manousis",fullName:"Thanasis Manousis",slug:"thanasis-manousis"},{id:"200287",title:"Prof.",name:"Sophia",middleName:null,surname:"Galinou-Mitsoudi",fullName:"Sophia Galinou-Mitsoudi",slug:"sophia-galinou-mitsoudi"}]},{id:"54666",title:"Mussel as a Tool to Define Continental Watershed Quality",slug:"mussel-as-a-tool-to-define-continental-watershed-quality",signatures:"Mélissa Palos Ladeiro, Iris Barjhoux, Aurélie Bigot-Clivot, Marc\nBonnard, Elise David, Odile Dedourge-Geffard, Elodie Geba, Emilie\nLance, Maxime Lepretre, Gabrielle Magniez, Damien Rioult,\nDominique Aubert, Isabelle Villena, Gaëlle Daniele, Arnaud\nSalvador, Emmanuelle Vulliet, Jean Armengaud and Alain Geffard",authors:[{id:"14169",title:"Dr.",name:"Aurelie",middleName:null,surname:"Bigot",fullName:"Aurelie Bigot",slug:"aurelie-bigot"},{id:"145053",title:"Dr.",name:"Dominique",middleName:null,surname:"Aubert",fullName:"Dominique Aubert",slug:"dominique-aubert"},{id:"145057",title:"Prof.",name:"Isabelle",middleName:null,surname:"Villena",fullName:"Isabelle Villena",slug:"isabelle-villena"},{id:"199642",title:"Dr.",name:"Melissa",middleName:null,surname:"Palos Ladeiro",fullName:"Melissa Palos Ladeiro",slug:"melissa-palos-ladeiro"},{id:"205006",title:"Dr.",name:"Iris",middleName:null,surname:"Barjhoux",fullName:"Iris Barjhoux",slug:"iris-barjhoux"},{id:"205007",title:"Dr.",name:"Marc",middleName:null,surname:"Bonnard",fullName:"Marc Bonnard",slug:"marc-bonnard"},{id:"205008",title:"Dr.",name:"Elise",middleName:null,surname:"David",fullName:"Elise David",slug:"elise-david"},{id:"205009",title:"Dr.",name:"Odile",middleName:null,surname:"Dedourge Geffard",fullName:"Odile Dedourge Geffard",slug:"odile-dedourge-geffard"},{id:"205010",title:"MSc.",name:"Elodie",middleName:null,surname:"Geba",fullName:"Elodie Geba",slug:"elodie-geba"},{id:"205011",title:"Prof.",name:"Alain",middleName:null,surname:"Geffard",fullName:"Alain Geffard",slug:"alain-geffard"},{id:"205012",title:"Dr.",name:"Emilie",middleName:null,surname:"Lance",fullName:"Emilie Lance",slug:"emilie-lance"},{id:"205013",title:"MSc.",name:"Maxime",middleName:null,surname:"Lepretre",fullName:"Maxime Lepretre",slug:"maxime-lepretre"},{id:"205014",title:"MSc.",name:"Gabrielle",middleName:null,surname:"Magniez",fullName:"Gabrielle Magniez",slug:"gabrielle-magniez"},{id:"205015",title:"Dr.",name:"Gaëlle",middleName:null,surname:"Daniele",fullName:"Gaëlle Daniele",slug:"gaelle-daniele"},{id:"205016",title:"Prof.",name:"Emmanuelle",middleName:null,surname:"Vulliet",fullName:"Emmanuelle Vulliet",slug:"emmanuelle-vulliet"},{id:"205018",title:"Prof.",name:"Arnaud",middleName:null,surname:"Salvador",fullName:"Arnaud Salvador",slug:"arnaud-salvador"},{id:"205019",title:"Prof.",name:"Jean",middleName:null,surname:"Armengaud",fullName:"Jean Armengaud",slug:"jean-armengaud"},{id:"205264",title:"Dr.",name:"Damien",middleName:null,surname:"Rioult",fullName:"Damien Rioult",slug:"damien-rioult"}]},{id:"54507",title:"Patellid Limpets: An Overview of the Biology and Conservation of Keystone Species of the Rocky Shores",slug:"patellid-limpets-an-overview-of-the-biology-and-conservation-of-keystone-species-of-the-rocky-shores",signatures:"Paulo Henriques, João Delgado and Ricardo Sousa",authors:[{id:"200407",title:"MSc.",name:"Paulo",middleName:null,surname:"Henriques",fullName:"Paulo Henriques",slug:"paulo-henriques"},{id:"200915",title:"MSc.",name:"Ricardo",middleName:null,surname:"Sousa",fullName:"Ricardo Sousa",slug:"ricardo-sousa"},{id:"200916",title:"MSc.",name:"João",middleName:null,surname:"Delgado",fullName:"João Delgado",slug:"joao-delgado"}]},{id:"54302",title:"Freshwater Mussels Exposed to Arsenic and Sulfate Show Contrasting Patterns of Gene Expression",slug:"freshwater-mussels-exposed-to-arsenic-and-sulfate-show-contrasting-patterns-of-gene-expression",signatures:"Pawel Michalak, Lin Kang, Serena Ciparis, William Henley, Jess\nJones, Andrew Phipps and Eric Hallerman",authors:[{id:"79633",title:"Prof.",name:"Eric",middleName:null,surname:"Hallerman",fullName:"Eric Hallerman",slug:"eric-hallerman"},{id:"199048",title:"Dr.",name:"Pawel",middleName:null,surname:"Michalak",fullName:"Pawel Michalak",slug:"pawel-michalak"},{id:"199049",title:"BSc.",name:"Kang",middleName:null,surname:"Lin",fullName:"Kang Lin",slug:"kang-lin"},{id:"199050",title:"Dr.",name:"Serena",middleName:null,surname:"Ciparis",fullName:"Serena Ciparis",slug:"serena-ciparis"},{id:"199051",title:"Dr.",name:"William",middleName:null,surname:"Henley",fullName:"William Henley",slug:"william-henley"},{id:"199052",title:"Dr.",name:"Jess",middleName:null,surname:"Jones",fullName:"Jess Jones",slug:"jess-jones"},{id:"199053",title:"BSc.",name:"Andrew",middleName:null,surname:"Phipps",fullName:"Andrew Phipps",slug:"andrew-phipps"}]},{id:"55965",title:"Spatiotemporal Neural Activities Involved in the Olfactory Processing of the Land Slug using Fluorescent-Imaging Technique",slug:"spatiotemporal-neural-activities-involved-in-the-olfactory-processing-of-the-land-slug-using-fluores",signatures:"Minoru Saito",authors:[{id:"200709",title:"Prof.",name:"Minoru",middleName:null,surname:"Saito",fullName:"Minoru Saito",slug:"minoru-saito"}]},{id:"54501",title:"Lipid Composition Modifications in the Blue Mussels (Mytilus edulis L.) from the White Sea",slug:"lipid-composition-modifications-in-the-blue-mussels-mytilus-edulis-l-from-the-white-sea",signatures:"Natalia N. Fokina, Tatiana R. Ruokolainen and Nina N. Nemova",authors:[{id:"199037",title:"Mrs.",name:"Natalia",middleName:null,surname:"Fokina",fullName:"Natalia Fokina",slug:"natalia-fokina"},{id:"199478",title:"Mrs.",name:"Tatiana",middleName:null,surname:"Ruokolainen",fullName:"Tatiana Ruokolainen",slug:"tatiana-ruokolainen"},{id:"199479",title:"Dr.",name:"Nina",middleName:null,surname:"Nemova",fullName:"Nina Nemova",slug:"nina-nemova"}]},{id:"55299",title:"An Insightful Model to Study Innate Immunity and Stress Response in Deep‐Sea Vent Animals: Profiling the Mussel Bathymodiolus azoricus",slug:"an-insightful-model-to-study-innate-immunity-and-stress-response-in-deep-sea-vent-animals-profiling-",signatures:"Raul Bettencourt, Inês Barros, Eva Martins, Inês Martins, Teresa\nCerqueira, Ana Colaço, Valentina Costa, Domitília Rosa, Hugo\nFroufe, Conceição Egas, Sergio Stefanni, Paul Dando and Ricardo S.\nSantos",authors:[{id:"201154",title:"Dr.",name:"Raul",middleName:null,surname:"Bettencourt",fullName:"Raul Bettencourt",slug:"raul-bettencourt"},{id:"205564",title:"Dr.",name:"Eva",middleName:null,surname:"Martins",fullName:"Eva Martins",slug:"eva-martins"},{id:"205565",title:"Dr.",name:"Inês",middleName:null,surname:"Martins",fullName:"Inês Martins",slug:"ines-martins"},{id:"205566",title:"Dr.",name:"Inês",middleName:null,surname:"Barros",fullName:"Inês Barros",slug:"ines-barros"},{id:"205567",title:"Ms.",name:"Teresa",middleName:null,surname:"Cerqueira",fullName:"Teresa Cerqueira",slug:"teresa-cerqueira"},{id:"205568",title:"Dr.",name:"Ana",middleName:null,surname:"Colaço",fullName:"Ana Colaço",slug:"ana-colaco"},{id:"205569",title:"Ms.",name:"Valentina",middleName:null,surname:"Costa",fullName:"Valentina Costa",slug:"valentina-costa"},{id:"205570",title:"Ms.",name:"Domitília",middleName:null,surname:"Rosa",fullName:"Domitília Rosa",slug:"domitilia-rosa"},{id:"205571",title:"Dr.",name:"Sergio",middleName:null,surname:"Stefanni",fullName:"Sergio Stefanni",slug:"sergio-stefanni"},{id:"205572",title:"MSc.",name:"Hugo",middleName:null,surname:"Froufe",fullName:"Hugo Froufe",slug:"hugo-froufe"},{id:"205573",title:"Dr.",name:"Conceição",middleName:null,surname:"Egas",fullName:"Conceição Egas",slug:"conceicao-egas"},{id:"205574",title:"Prof.",name:"Paul",middleName:null,surname:"Dando",fullName:"Paul Dando",slug:"paul-dando"},{id:"205575",title:"Dr.",name:"Ricardo",middleName:null,surname:"Serrão Santos",fullName:"Ricardo Serrão Santos",slug:"ricardo-serrao-santos"}]},{id:"55399",title:"Gut Microbiome Analysis of Snails: A Biotechnological Approach",slug:"gut-microbiome-analysis-of-snails-a-biotechnological-approach",signatures:"Mudasir A. Dar, Kiran D. Pawar and Radhakrishna S. Pandit",authors:[{id:"201161",title:"Mr.",name:"Mudasir",middleName:null,surname:"Dar",fullName:"Mudasir Dar",slug:"mudasir-dar"},{id:"201162",title:"Prof.",name:"Radhakrishna S",middleName:null,surname:"Pandit",fullName:"Radhakrishna S Pandit",slug:"radhakrishna-s-pandit"},{id:"201163",title:"Dr.",name:"Kiran D",middleName:null,surname:"Pawar",fullName:"Kiran D Pawar",slug:"kiran-d-pawar"}]},{id:"54699",title:"The Uniqueness of Achatina fulica in its Evolutionary Success",slug:"the-uniqueness-of-achatina-fulica-in-its-evolutionary-success",signatures:"Sandip Mukherjee, Shuvasree Sarkar, Chayan Munshi and Shelley\nBhattacharya",authors:[{id:"182285",title:"Prof.",name:"Shelley",middleName:null,surname:"Bhattacharya",fullName:"Shelley Bhattacharya",slug:"shelley-bhattacharya"}]}]}],publishedBooks:[{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,isOpenForSubmission:!1,hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",slug:"endoplasmic-reticulum",bookSignature:"Angel Català",coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",editedByType:"Edited by",editors:[{id:"196544",title:"Prof.",name:"Angel",surname:"Catala",slug:"angel-catala",fullName:"Angel Catala"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6964",title:"Cell Culture",subtitle:null,isOpenForSubmission:!1,hash:"045f3a964a9628162956abc06ef5777d",slug:"cell-culture",bookSignature:"Radwa Ali Mehanna",coverURL:"https://cdn.intechopen.com/books/images_new/6964.jpg",editedByType:"Edited by",editors:[{id:"182118",title:"Dr.",name:"Radwa Ali",surname:"Mehanna",slug:"radwa-ali-mehanna",fullName:"Radwa Ali Mehanna"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7121",title:"Cell Growth",subtitle:null,isOpenForSubmission:!1,hash:"9845b4d66ecca197908bcbfe4fd89321",slug:"cell-growth",bookSignature:"Biba Vikas and Michael Fasullo",coverURL:"https://cdn.intechopen.com/books/images_new/7121.jpg",editedByType:"Edited by",editors:[{id:"241658",title:"Dr.",name:"Biba",surname:"Vikas",slug:"biba-vikas",fullName:"Biba Vikas"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7264",title:"Calcium and Signal Transduction",subtitle:null,isOpenForSubmission:!1,hash:"e373a3d1123dbd45fddf75d90e3e7c38",slug:"calcium-and-signal-transduction",bookSignature:"John N. Buchholz and Erik J. Behringer",coverURL:"https://cdn.intechopen.com/books/images_new/7264.jpg",editedByType:"Edited by",editors:[{id:"89438",title:"Dr.",name:"John N.",surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8774",title:"Programmed Cell Death",subtitle:null,isOpenForSubmission:!1,hash:"0459d0c7a518f61817a48fd4709c35bd",slug:"programmed-cell-death",bookSignature:"Hala Gali-Muhtasib and Omar Nasser Rahal",coverURL:"https://cdn.intechopen.com/books/images_new/8774.jpg",editedByType:"Edited by",editors:[{id:"57145",title:"Prof.",name:"Hala",surname:"Gali-Muhtasib",slug:"hala-gali-muhtasib",fullName:"Hala Gali-Muhtasib"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3361",title:"Regenerative Medicine and Tissue Engineering",subtitle:null,isOpenForSubmission:!1,hash:"fe914d49a96b3dcd00d27292ae23536e",slug:"regenerative-medicine-and-tissue-engineering",bookSignature:"Jose A. Andrades",coverURL:"https://cdn.intechopen.com/books/images_new/3361.jpg",editedByType:"Edited by",editors:[{id:"40914",title:"Prof.",name:"Jose A.",surname:"Andrades",slug:"jose-a.-andrades",fullName:"Jose A. Andrades"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4486",title:"Cells and Biomaterials in Regenerative Medicine",subtitle:null,isOpenForSubmission:!1,hash:"1c333e655d47208db36f2a886b49c160",slug:"cells-and-biomaterials-in-regenerative-medicine",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/4486.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6883",title:"Cell Signalling",subtitle:"Thermodynamics and Molecular Control",isOpenForSubmission:!1,hash:"e4e17d85c0643c7f4d274fa9adbcc628",slug:"cell-signalling-thermodynamics-and-molecular-control",bookSignature:"Sajal Ray",coverURL:"https://cdn.intechopen.com/books/images_new/6883.jpg",editedByType:"Edited by",editors:[{id:"173697",title:"Prof.",name:"Sajal",surname:"Ray",slug:"sajal-ray",fullName:"Sajal Ray"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"82862",title:"Assessment of Genetic Variability of Three Types of Sorghum Cultivated in Burkina Faso Using Morphoagronomic Quantitative Traits and Brix",doi:"10.5772/intechopen.105984",slug:"assessment-of-genetic-variability-of-three-types-of-sorghum-cultivated-in-burkina-faso-using-morphoa",body:'
1. Introduction
Burkina Faso is a Sahelian country whose socioeconomic development is mainly based on agriculture [1]. The agricultural sector employs about 80% of the total population and is the country’s main provider of food resources [2]. However, agricultural production is affected by climatic hazards such as irregular rainfall and shortened rainy seasons, resulting in huge yield losses and permanent food insecurity [3]. To cope with these climatic constraints, crop diversification appears to be the most appropriate solution for resilient agriculture.
In Sahelian countries such as Niger, Mali, Senegal, and Burkina Faso, cereals are the staple food of the population [4]. Sorghum [Sorghum bicolor (L.) Moench] is the most important crop. Moreover, it is the main food crop for millions of people and excellent fodder for animals in semiarid and arid tropical areas [5]. Sorghum is the fifth most important cereal crop in the world and the third most important in Africa after maize and rice in terms of production volume and area sown [6].
In Burkina Faso, sorghum is the second most important cereal crop after maize, with an estimated total production of 1,839,570 tonnes, including 1,425,103 tonnes of white sorghum and 414,467 tonnes of red sorghum [7]. However, these statistics do not highlight all types of sorghum produced. Indeed, several types of sorghum with varied but little known potential are grown in Burkina Faso and maintained by farmers [8, 9, 10]. These include grain sorghum, sweet grain sorghum, sweet sorghum, and dyer sorghum [11]. These sorghums are mainly exploited for human consumption for their grains or the sweet juice from their stems, for animal feed for their straw, and for dyeing for their strongly anthocyanated leaf sheaths [11]. The dynamic management of this diversity by farmers allows for evolutionary adjustment to a heterogeneous environment, but also to meet diversified use needs [12]. Most previous studies focusing on genetic diversity within each sorghum type have reported the existence of genetic diversity within grain sorghum [12, 13, 14], sweet grain sorghum [10], and sweet sorghum [11]. In addition, grain sorghum and sweet sorghum have been the subject of several scientific works. However, work on sweet grain sorghum is relatively recent [9, 10, 15, 16]. Therefore, information on the distinctive agro-morphological traits of this sorghum compared with other cultivated sorghums remains scarce. This could constitute a constraint to the rational exploitation of the potential of this genetic resource in breeding programs. To date, few studies on the genetic relationships between sweet grain sorghum and other sorghum types grown in Burkina Faso have been carried out using nuclear and chloroplast molecular markers. Although the results obtained showed genetic proximity between these sorghum types [17, 18], the evaluation of these sorghums under identical cropping conditions could help identify agro-morphological and biochemical traits specific to sweet grain sorghum that could be exploited in sorghum improvement programs. Thus, the present study aims to compare the quantitative agro-morphological and biochemical characteristics of sweet grain sorghum with grain sorghum and sweet sorghum grown in Burkina Faso. In particular, the aim is to (i) determine the agro-morphological and biochemical traits of sweet grain sorghum that are similar to those of other cultivated sorghums, (ii) identify the distinctive traits, and (iii) evaluate the effect of the factors “genotype” and “sorghum type” on the variability of the three types of sorghum grown in Burkina Faso.
2. Material and method
2.1 Plant material
The plant material consisted of 42 sorghum genotypes including 22 sweet grain sorghum, 10 sweet sorghum, and 10-grain sorghum (common sorghum). The seeds of sweet grain sorghum and sweet sorghum came from the germplasm of the Laboratoire Biosciences of Université Joseph KI-ZERBO. The seeds of grain sorghum were obtained from the “Institut de L’Environment et de Recherche Agricole (INERA),” “Kamboinsé,” Burkina Faso.
2.2 Experimental site
The agro-morphological evaluation took place under rainfed conditions in 2020 at the experimental station of the “Institut du Développement Rural (IDR)” in “Gampéla.” The locality is located in the northern Sudanese climatic zone with geographical coordinates of 12°25’ North latitude and 1°21’ West longitude. The soil is very heterogeneous, deep, of low chemical fertility, and predominantly sandy loam texture [19]. During the trial from July to October, the average monthly temperature ranged between 26 and 28°C for a cumulative rainfall of 769 mm.
2.3 Experimental design
The experimental setup was an incomplete Fisher block with three replications, each subdivided into three sub-blocks. Each sub-block consisted of 14 lines and 11 patches per line with 0.8 m row spacing and 0.4 m inter-patches. Each replication had 42 lines with one line per genotype and two borderlines. The distances between replications and sub-blocks were respectively 2 and 1 m for a total area of 504 m2.
2.4 Cultivation techniques
The field was plowed with a tractor and leveled before sowing on July 18, 2020. In the course of the trial, a wedding with one plant per stake was carried out 15 days after sowing, followed by two weedings on the 18th and 35th day after sowing respectively. Ridging was then carried out toward the end of the vegetative development of the plants in order to counteract the lodging caused by the high winds. NPK fertilizer (14–23-14) was applied at each weeding at a rate of 50 kg/ha, and urea was applied at the time of weeding at a rate of 50 kg/ha.
2.5 Data collection
A total of 20 quantitative traits, of which 19 were agro-morphological and one (01) biochemical, were determined by measurement or counting. These traits are related to phenology, vegetative organ characteristics, yield parameters, and soluble sugar content (Brix).
2.5.1 Phenology-related traits
Four variables have been determined. These are the sowing-emergence cycle, the sowing-heading cycle, the sowing-flowering cycle, and the heading-flowering difference.
2.5.2 Vegetative-organs-related traits and the soluble sugar content of the stem (Brix)
The leaf characteristics were the number of leaves per plant, the length of the third leaf under the panicle, the width of the third leaf under the panicle, the length of the leaf sheath, and the separation, which corresponds to the half-distance between the base of the blade of the third leaf and the fifth leaf under the panicle. On the stem, the length of the internode, the number of internodes, the diameter of the main stem, and the number of vegetative tillers were determined. The height of the plant at maturity (HPL) was also measured. The soluble sugar content of the stem (Brix) was determined at the hard grain stage using a portable digital refractometer (ATAGO PAL-α) with an accuracy of ±0.2% on the two central internodes located in the middle of the stem.
2.5.3 Yield-related traits
Five traits were measured. These are the number of productive tillers per plant, the length of the peduncle, the weight of 100 grains, and the length and width of the panicle.
2.6 Data analysis
Data processing and analysis were carried out with the Excel 2016 spreadsheet and Xlstat 2016 software. An analysis of variance coupled with a Newman–Keuls test of the separation of means at the 5% threshold was carried out in order to evaluate the variability of the material studied and to determine on the one hand the variables that discriminate the types of sorghum and on the other hand the effects of the factors “genotype” and “type of sorghum” on the expression of the characters through the coefficient of determination (R2). A principal component analysis (PCA) was also carried out to highlight the variables that characterize each type of sorghum. A hierarchical ascending classification (HAC) was finally carried out according to the genotypes, using the majority of the quantitative characters in order to observe the grouping of the genotypes. The groups obtained were finally characterized by discriminant factor analysis (DFA).
3. Results
3.1 Comparison of sweet grain sorghum with other cultivated sorghums based on phenology-related traits
The results recorded in Table 1 showed an absence of significant differences between sweet grain sorghum and the two other types of sorghum grown in Burkina for the number of days to emergence and the sowing-flowering cycle. On the other hand, the two other characteristics significantly discriminated grain sorghum from the two other sorghum types. Indeed, it has a longer sowing-flowering cycle and a shorter mean time to flowering (1 day) than sweet sorghum (3 days) and grain sorghum (4 days).
Traits
Sweet grain sorghum
Grain sorghum
Sweet sorghum
Sowing-emergence cycle (days)
3.206 a
3.0331 a
3.100 a
Sowing-heading cycle (days)
72.810 b
70.467 a
69.800 a
Sowing-flowering cycle (days)
73.920 a
74.300 a
72.801 a
Heading-flowering difference (days)
1.111 a
3.834 c
3.000 b
Table 1.
Results of the Newman–Keuls mean separation test of phenological traits according to sorghum type.
a, b, c: values followed by the same letters are not significantly different at the 5% threshold.
3.2 Comparison of sweet grain sorghum with other cultivated sorghums based on vegetative traits and soluble sugar content of the stem
The analysis of the results in Table 2 reveals that of the 10 agro-morphological traits, only the number of leaves and the number of internodes did not significantly discriminate the three types of sorghum studied. A significant difference was observed between sweet grain sorghum and the other two sorghums in terms of leaf sheath length and stem diameter. Indeed, sweet grain sorghum was clearly distinguished from the other two types of sorghum by longer leaf sheaths and larger stem diameter. However, it has similar characteristics to grain sorghum in terms of leaf size and sweet sorghum in terms of vegetative shoot production, separation, internode length, and plant height.
Traits
Sweet grain sorghum
Grain sorghum
Sweet sorghum
Vegetative tillers
1.532 b
0.667 a
1.442 b
Leaves number
12.040 a
12.575 a
11.867 a
Leaf length (cm)
68.809 a
68.376 a
73.199 b
Leaf width (cm)
9.570 b
9.405 b
8.075 a
Leaf sheath length (cm)
21.742 b
20.121 a
19.867 a
Separation (cm)
21.310 b
13.869 a
20.745 b
Internodes number
11.492 a
11.608 a
10.783 a
Internodes length (cm)
21.518 b
14.421 a
20.704 b
Stem diameter (cm)
2.1218 b
2.0350 ab
1.9350 a
Plant height (cm)
263.508 b
199.116 a
259.801 b
Brix (%)
12.324 a
13.975 b
18.885 c
Table 2.
Results of the Newman–Keuls mean separation test of vegetative traits and Brix according to sorghum type.
a, b, c: values followed by the same letters are not significantly different at the 5% threshold.
As for the soluble sugar content (Brix), a significant variation according to the type of sorghum was observed. Sweet grain sorghum expressed a Brix value (12.32%) significantly lower than grain sorghum (13.98%) and sweet sorghum (18.89%).
3.3 Comparison of sweet grain sorghum with other cultivated sorghums based on yield-related traits
All yield-related traits significantly discriminated all cultivated sorghum types (Table 3) but panicle length showed no significant difference between sweet grain and sweet sorghum. Sweet grain sorghum is clearly distinguished from the other two types of sorghum by an intermediate peduncle length, wider panicles, lighter grains, and a higher number of productive tillers.
Traits
Sweet grain sorghum
Grain sorghum
Sweet sorghum
Productive tillers
0.155 b
0.017 a
0.092 ab
Peduncle length (cm)
50.789 ab
45.413 a
54.093 b
Panicle width (cm)
10.807 c
9.573 b
8.492 a
Panicle length (cm)
28.158 a
32.891 b
27.972 a
100-grain weight (g)
2.438 a
2.629 b
2.695 b
Table 3.
Results of the Newman–Keuls mean separation test of yield and Brix parameters according to sorghum type.
a, b, c: values followed by the same letters are not significantly different at the 5% threshold.
3.4 Effect of “genotype” factor and “sorghum type” factor on trait expression
The results recorded in Table 4 showed variability of the material at the level of most of the characters except for the number of productive tillers. The comparative analysis of the coefficients of determination (R2) revealed a preponderance of the genotype factor in the expression of all the characteristics, explained by higher values (>50%) except for the production of productive tillers (36%). However, the influence of the “sorghum type” factor was quite important in the expression of heading-flowering difference (54%), Brix (44%), panicle width (37%), and plant height (31%).
Factors
Genotype
Sorghum type
Traits
Pr > F
R2
R2
Pr > F
Sowing-emergence cycle
0.010
0.50
0.05
0.070
Sowing-heading cycle
< 0.0001
0.70
0.10
0.003
Sowing-flowering cycle
< 0.0001
0.71
0.02
0.378
Heading-flowering difference
< 0.0001
0.83
0.54
< 0.0001
Vegetative tillers
< 0.0001
0.60
0.19
< 0.0001
Leaves number
< 0.0001
0.72
0.03
0.221
Leaf length
< 0.0001
0.66
0.09
0.004
Leaf width
< 0.0001
0.82
0.22
< 0.0001
Leaf sheath length
0.000
0.59
0.11
0.002
Separation
< 0.0001
0.93
0.31
< 0.0001
Internodes number
< 0.0001
0.74
0.03
0.140
Internodes length
< 0.0001
0.88
0.28
< 0.0001
Stem diameter
< 0.0001
0.68
0.10
0.002
Plant height
< 0.0001
0.87
0.31
< 0.0001
Brix
< 0.0001
0.75
0.44
< 0.0001
Productive tillers
0.459
0.36
0.06
0.026
Peduncle length
< 0.0001
0.96
0.8
0.009
Panicle width
< 0.0001
0.65
0.37
< 0.0001
Panicle length
< 0.0001
0.88
0.18
< 0.0001
100-grain weight
< 0.0001
0.61
0.11
0.001
Table 4.
Effects of genotype and sorghum type factors on the expression of the studied traits.
F: Fisher value, Pr; probability, R2: coefficient of determination.
3.5 Description of sorghum types grown
The results of the principal component analysis (PCA) indicate that the first two axes contribute 100% of the total variance (Figure 1). Thus, the projection in the ½ plane in the biplot of the variables and the sorghum type factor shows that axis 1 with an inertia rate of 55.06% negatively associated with the variables’ sowing-flowering cycle, the number of internodes, leaf width, stem diameter, and panicle width and positively the variables leaf length and Brix. Axis 2, which explains 44.94% of the total variability, is positively associated with the variables panicle length, mean heading-flowering distance, and 100-grain weight. They are opposite to the variables plant height, vegetative tillering, and productive tillering. The biplot shows that sweet sorghum positively related to axis 1 is characterized by long leaves and a high Brix value. Grain sorghum positively associated with axis 2 is opposite to sweet grain sorghum. Sweet grain sorghum is characterized by a short panicle, a short difference between flowering and heading, taller plants, and a large number of vegetative and productive tillers. Grain sorghum is characterized by a long panicle, a long average time between flowering and heading, shorter plants, and a smaller number of vegetative and productive tillers. Moreover, the analysis of Euclidean distances (Table 5) revealed greater proximity between sweet grain sorghum and sweet sorghum (11.025). The greatest distance was recorded between sweet grain sorghum and grain sorghum (65.771).
Figure 1.
Projection of variables and sorghum types in the ½ plane of the principal component analysis. Legend: STS: sweet sorghum, SGO: Grain sorghum, SGS: Sweet grain sorghum, NJF: Sowing – flowering cycle, EE-F: Difference flowering - earing, TAV: Vegetative tillers, LAF: Leaf width, LOF: Leaf length, NEN: Internodes number, DTI: Stem diameter, HPL: Plant height, TAU: Productive tillers, LAP: Panicle width, LOP: Peduncle length, PCG: 100-grain weight.
Sweet grain sorghum
Grain sorghum
Sweet sorghum
Grain sorghum
65.771
0
Sweet sorghum
11.025
62.676
0
Table 5.
Matrix of Euclidean distance between sorghum types.
3.6 Organization of the diversity of sorghum grown in Burkina Faso
The dendrogram (Figure 2) derived from the hierarchical ascending classification (HAC), based on the Euclidean distances between individuals, divides the sorghum genotypes into three groups with one truncation at inertia level 100 (truncation 1) independently of the sorghum types. Thus, group I consists of all sweet grain sorghum genotypes and three sweet sorghum genotypes. Group II is composed of five sweet sorghum genotypes and two-grain sorghum genotypes. Group III consists of seven-grain sorghum genotypes and two sweet sorghum genotypes. In addition, a subdivision of group I genotypes into sweet grain sorghum and sweet sorghum is observed at truncation level 50 (truncation 2) conforming sweet grain sorghum is more homogeneous. Sweet sorghum is the most heterogeneous as its genotypes are distributed in all three groups.
Figure 2.
Dendrogram of the hierarchical ascending classification of the genotypes of the three types of sorghum grown in Burkina Faso. Legend: STS: sweet sorghum.
3.7 Characterization of the sorghum groups obtained
The characterization of the groups obtained from AHC by discriminant factor analysis (DFA) is shown in Figure 3. Group I, which includes all sweet grain sorghum genotypes and three sweet sorghum genotypes, is characterized by wider stalks and panicles and a greater number of productive tillers. Group II, which is mainly made up of sweet sorghum genotypes, is characterized by taller plants, longer internodes and panicles, and a higher Brix value. Group III, which is predominantly grain sorghum, contains genotypes with a longer sowing-flowering cycle, a longer mean time between flowering and heading, a higher number of internodes, and wider leaves.
Figure 3.
Position of groups from the bottom-up classification in discriminant factor analysis (DFA).
4. Discussion
The absence of significant differences between the three types of sorghum grown in Burkina Faso in terms of the characters, sowing-emergence cycle, sowing-flowering cycle, number of internodes, and number of leaves, coupled with the low influence of the “sorghum type” factor in the expression of the characters, could testify to the genetic proximity between the three types of sorghum grown. This is confirmed by the organization of genotypes into agro-morphological groups independently of the “sorghum type” factor in the hierarchical ascending classification. Similar results are reported by [18] and [17] on these sorghum types using molecular markers. Indeed, the three sorghum types generally coexist in combination in traditional production systems. A gene flow could exist between them insofar as sorghum, although it is preferentially self-pollinated, has an outcrossing rate that can vary from 7–40% [20, 21]. The genetic proximity between these sorghums could confirm that they belong to the same species [17]. Therefore, the only determining factor in their differentiation would be the genotype, hence the high values of coefficients of determination recorded in the study with this factor. However, the smaller gap between heading and flowering observed in sweet grain sorghum and its preferential harvesting at the doughy grain stage could explain its earliness compared with the two types of sorghum grown. In addition, the duration of the sowing-flowering cycle of all three types of sorghum studied is lower than the results reported by [22] on sweet sorghum (76 days), by [23] on sweet grain sorghum (91 days), and by [24] on grain sorghum (79 days). This difference could be explained by the late establishment of the trial. Flowering was early and clustered for the genotypes of the three sorghum types studied. These results could be explained by the sensitivity of these sorghums to photoperiod variation as reported by several previous studies [24, 25, 26].
Seven of the 15 characteristics related to vegetative organs and yield, as well as the Brix, made it possible to clearly discriminate sweet grain sorghum from grain sorghum and sweet sorghum. Indeed, sweet grain sorghum is characterized by a more robust and less sweet stem emitting more productive tillers, longer leaf sheaths, a wider panicle supported by an intermediate-sized peduncle, and carrying lighter grains. This is confirmed by principal component analysis, which revealed an association between this sorghum and these variables. Similar results on panicle width and grain weight of sweet grain sorghum and Brix are reported in previous studies [10, 17]. The weak grain weight of sweet grain sorghum could be explained by its asymmetric shape and mealy consistency in contrast to the other two types, which have elliptical and glassier grains. In addition, the weakly stem Brix value of sweet grain sorghum compared with sweet sorghum and grain sorghum could be related to a difference in the accumulation organs. Sweet grain sorghum would accumulate its sugars a lot in the grains as the stem. Moreover, some sweet grain sorghum and grain sorghum genotypes expressed higher Brix values than some sweet sorghum genotypes. This suggests that Brix is a trait more influenced by genotype than sorghum type, which is a simple classification criterion. Similar results were reported by [27] on grain sorghum under mineral fertilization conditions and [22] on sweet sorghum (8.88–21.83%). The Brix would be a polygenic trait with epistatic interactions and additive effects [28, 29, 30] unlike the sweet taste of the grain, which is controlled by a single biallelic gene [31, 32].
Finally, several results obtained revealed greater genetic proximity between grain sorghum and sweet stem sorghum. Indeed, among the variables discriminating the types of sorghum, similar characteristics were recorded between sweet grain sorghum and sweet sorghum in five variables (number of vegetative tillers, separation, internode length, plant height, panicle length). However, only two of these variables, i.e., leaf length and width, bring sweet grain sorghum closer to grain sorghum. This is confirmed on the one hand by the Euclidean distances, which showed a smaller distance between sweet sorghums and on the other hand by the results of the hierarchical classification where a composite group consisting of all sweet grain sorghum genotypes and three sweet sorghum genotypes was obtained. [18] also showed that sweet sorghums (sweet sorghum, sweet grain sorghum) are genetically more closely related (Fst = −0.0558) to grain sorghum [17], however, showed greater proximity between sweet grain sorghum and grain sorghum using molecular markers. This difference in molecular and phenotypic proximity could be explained by the generally polygenic determinism of the traits taken into account in the estimation of phenotypic distance, which can lead to convergence phenomena [33]. According to [34], lines with the same value for a quantitative trait may have different alleles for each of the loci involved. The effect of environmental factors on phenotype expression could also explain this difference in molecular and phenotypic distances.
Finally, the fact that all sweet grain sorghum genotypes belong to the same agro-morphological group could indicate a greater homogeneity of this type of sorghum compared with the other two types [17] also reported low diversity within this sorghum type compared with the other two sorghum types.
5. Conclusion
The study revealed a weak influence of the factor “type of sorghum” in the expression of all the characters. Nine characters, including two related to phenology, six to vegetative organs and yield, and Brix, allowed us to distinguish sweet grain sorghum from sweet sorghum and grain sorghum. Sweet grain sorghum is characterized by a robust, low-sugar stem, longer leaf sheaths, a broad panicle, and lighter grains. The study shows also that sweet sorghums are genetically similar to grain sorghum. These results could contribute to better management of sorghum genetic resources in Burkina Faso through their use in the national sorghum breeding program. Indeed, crosses could be made between these different types of cultivated sorghum to create single, three-way or double hybrids containing sweet grains and sweet stems. These hybrids could then be evaluated in multi-location trials in contrasting environments to select genotypes by environment. Marker-assisted selection could also be used to identify drought-tolerant genotypes of interest. Furthermore, the analysis of the nutritional composition of the grains of these genotypes of interest, in particular their profile in essential amino acids (lysine), vitamins, and sugars, could be the basis for their exploitation in the food industry for the manufacture of infant porridges and biscuits.
Acknowledgments
This paper is dedicated by the coauthors to Boureima sawadogo, who passed away in November 2021. The coauthors would like to acknowledge Members of “Laboratoire Biosciences” for their assistance. They would also like to thank sincerely Dr. Mariam Kiébré for the corrections and suggestions.
Conflicts of interest
The authors declare that they have no conflicts of interest regarding the publication of this paper.
Funding statement
The research was funded by the authors.
Data availability
The data supporting the findings of this study are available on request from the corresponding author.
C Laboratoire Biosciences, Université Joseph KI-ZERBO, Burkina Faso
'}],corrections:null},book:{id:"11643",type:"book",title:"Genetic Diversity - Recent Advances and Applications",subtitle:null,fullTitle:"Genetic Diversity - Recent Advances and Applications",slug:null,publishedDate:null,bookSignature:"Prof. Mahmut Çalışkan and Dr. Sevcan Aydin",coverURL:"https://cdn.intechopen.com/books/images_new/11643.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80356-945-1",printIsbn:"978-1-80356-944-4",pdfIsbn:"978-1-80356-946-8",isAvailableForWebshopOrdering:!0,editors:[{id:"51528",title:"Prof.",name:"Mahmut",middleName:null,surname:"Çalışkan",slug:"mahmut-caliskan",fullName:"Mahmut Çalışkan"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"238088",title:"MSc.",name:"Joseane",middleName:null,surname:"Nascimento Da Conceição",email:"joseanenascimento13@gmail.com",fullName:"Joseane Nascimento Da Conceição",slug:"joseane-nascimento-da-conceicao",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:{name:"Universidade Federal do Recôncavo da Bahia",institutionURL:null,country:{name:"Brazil"}}},booksEdited:[],chaptersAuthored:[{id:"62370",title:"Morphology, Physical and Chemical Characteristics of Mangrove Soil under Riverine and Marine Influence: A Case Study on Subaé River Basin, Bahia, Brazil",slug:"morphology-physical-and-chemical-characteristics-of-mangrove-soil-under-riverine-and-marine-influenc",abstract:"The preservation of mangrove ecosystem requires knowledge on soil Morphology, Physical and Chemical Characteristics, for understanding the requirements for their sustainability and preservation. Seven pedons of mangrove soil, five under fluvial and two under marine influence, located in the Subaé River basin were described and classified. Samples of horizons were collected for physical and chemical analyses, including Pb and Cd. The moist soils were suboxidic, with Eh below 350 mV. The pH of the pedons under fluvial influence ranged from moderately acid to alkaline, and pedons under marine influence was around 7.0. Mangrove soils under fluvial influence were characterized with the highest Pb and Cd concentrations in the pedons, which could be perhaps due to it closeness to the mining company Plumbum, while the lowest Pb concentrations was registered in the pedon furthest from the factory. Because the pedons had at least one metal above the reference level they were considered potentially toxic. The soils were classified as Gleissolos Tiomórficos Órticos (sálicos) sódico neofluvissólico, according to the Brazilian Soil Classification System and as Thiomorphic orthic Gleysol (salic) sodicluvissol (potentially toxic, very poorly drained) according with FAO. The pedon under marine influence was classified in the same subgroup, but the metal concentrations met the acceptable standard.",signatures:"Marcela Rebouças Bomfim, Jorge Antônio Gonzaga Santos, Oldair\nVinhas Costa, Joseane Nascimento da Conceiçao, Alyne Araújo da\nSilva, Claudineia de Souza Souza and Maria da Conceição de\nAlmeida",authors:[{id:"216986",title:"Ph.D.",name:"Marcela",surname:"Rebouças Bomfim",fullName:"Marcela Rebouças Bomfim",slug:"marcela-reboucas-bomfim",email:"reboucas.marcela@gmail.com"},{id:"217000",title:"Dr.",name:"Jorge Antonio",surname:"Gonzaga Santos",fullName:"Jorge Antonio Gonzaga Santos",slug:"jorge-antonio-gonzaga-santos",email:"gonzaga.jorgeas@gmail.com"},{id:"217003",title:"Dr.",name:"Oldair",surname:"Vinhas Costa",fullName:"Oldair Vinhas Costa",slug:"oldair-vinhas-costa",email:"oldairvinhas@gmail.com"},{id:"238088",title:"MSc.",name:"Joseane",surname:"Nascimento Da Conceição",fullName:"Joseane Nascimento Da Conceição",slug:"joseane-nascimento-da-conceicao",email:"joseanenascimento13@gmail.com"},{id:"238090",title:"MSc.",name:"Alyne",surname:"Araújo Da Silva",fullName:"Alyne Araújo Da Silva",slug:"alyne-araujo-da-silva",email:"alyne.agro@gmail.com"},{id:"238092",title:"Dr.",name:"Maria Da Conceição",surname:"De Almeida",fullName:"Maria Da Conceição De Almeida",slug:"maria-da-conceicao-de-almeida",email:"marycalmeida@yahoo.com.br"}],book:{id:"6411",title:"Mangrove Ecosystem Ecology and Function",slug:"mangrove-ecosystem-ecology-and-function",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"87846",title:"Dr.",name:"Eusebio",surname:"Cano Carmona",slug:"eusebio-cano-carmona",fullName:"Eusebio Cano Carmona",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRsK0QAK/Profile_Picture_2022-06-29T05:32:24.PNG",biography:"Eusebio Cano Carmona, Ph.D. in Science from the University of Granada, Spain; A Professor of Botany at the University of Jaén, Spain. His fundamental line of research is Flora and Vegetation. We have focused our research on Spain, Italy, Portugal, Palestine, the Caribbean islands, and Mexico; As a result of these investigations, we have directed 13 doctoral theses, and some 250 publications including articles, books, and book chapters. He participates in national and international congresses with about 200 papers/communications. We have held different academic positions. Director of the Dean of the Faculty of Experimental Sciences. Founder and Director of the International Seminar on Management and Conservation of Biodiversity for 14 years. Member of the Spanish, Portuguese, and Italian Geobotany societies. Counselor of the I.E.G His academic and teaching career focuses on Geobotany, teaching classes in the Biological Sciences degree and in the master's degree in olive groves and olive oil, his research has focused mainly on flora and vegetation, carrying out cartographic projects for the habitats of Europe.",institutionString:null,institution:{name:"University of Jaén",institutionURL:null,country:{name:"Spain"}}},{id:"203697",title:"Dr.",name:"Ana",surname:"Cano Ortiz",slug:"ana-cano-ortiz",fullName:"Ana Cano Ortiz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/203697/images/system/203697.jpg",biography:null,institutionString:null,institution:{name:"University of Jaén",institutionURL:null,country:{name:"Spain"}}},{id:"215767",title:"Prof.",name:"Jing",surname:"Xu",slug:"jing-xu",fullName:"Jing Xu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Hainan University",institutionURL:null,country:{name:"China"}}},{id:"216978",title:"Dr.",name:"Piñar Fuentes",surname:"J.C.",slug:"pinar-fuentes-j.c.",fullName:"Piñar Fuentes J.C.",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Jaén",institutionURL:null,country:{name:"Spain"}}},{id:"227149",title:"Prof.",name:"Shaoliang",surname:"Chen",slug:"shaoliang-chen",fullName:"Shaoliang Chen",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"232428",title:"Prof.",name:"Niya",surname:"Li",slug:"niya-li",fullName:"Niya Li",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"232429",title:"Prof.",name:"Xiaoyang",surname:"Zhou",slug:"xiaoyang-zhou",fullName:"Xiaoyang Zhou",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"232430",title:"Prof.",name:"Ruigang",surname:"Wang",slug:"ruigang-wang",fullName:"Ruigang Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"232431",title:"Mrs.",name:"Jinke",surname:"Li",slug:"jinke-li",fullName:"Jinke Li",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"232432",title:"Prof.",name:"Cunfu",surname:"Lu",slug:"cunfu-lu",fullName:"Cunfu Lu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"open-access-funding",title:"Open Access Funding",intro:"
IntechOpen’s Academic Editors and Authors have received funding for their work through many well-known funders, including: the European Commission, Bill and Melinda Gates Foundation, Wellcome Trust, Chinese Academy of Sciences, Natural Science Foundation of China (NSFC), CGIAR Consortium of International Agricultural Research Centers, National Institute of Health (NIH), National Science Foundation (NSF), National Aeronautics and Space Administration (NASA), National Institute of Standards and Technology (NIST), German Research Foundation (DFG), Research Councils United Kingdom (RCUK), Oswaldo Cruz Foundation, Austrian Science Fund (FWF), Foundation for Science and Technology (FCT), Australian Research Council (ARC).
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\\n\\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\\n\\n
\\n\\t
Does your institution already have a budget for covering Open Access publication costs?
\\n\\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\\n
\\n\\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\\n\\n
Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
\\n\\n
Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\n\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\n\n
\n\t
Does your institution already have a budget for covering Open Access publication costs?
\n\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\n
\n\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\n\n
Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
\n\n
Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:13389},{group:"region",caption:"Middle and South America",value:2,count:11660},{group:"region",caption:"Africa",value:3,count:4168},{group:"region",caption:"Asia",value:4,count:22334},{group:"region",caption:"Australia and Oceania",value:5,count:2019},{group:"region",caption:"Europe",value:6,count:33642}],offset:12,limit:12,total:135275},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasnoeditors:"0",sort:"dateendthirdsteppublish"},books:[],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:27},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:7},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:16},{group:"topic",caption:"Computer and Information Science",value:9,count:18},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:8},{group:"topic",caption:"Engineering",value:11,count:42},{group:"topic",caption:"Environmental Sciences",value:12,count:5},{group:"topic",caption:"Immunology and Microbiology",value:13,count:8},{group:"topic",caption:"Materials Science",value:14,count:17},{group:"topic",caption:"Mathematics",value:15,count:9},{group:"topic",caption:"Medicine",value:16,count:68},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:3},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:7},{group:"topic",caption:"Physics",value:20,count:6},{group:"topic",caption:"Psychology",value:21,count:5},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:7},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:0,limit:12,total:null},popularBooks:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3737",title:"MATLAB",subtitle:"Modelling, Programming and Simulations",isOpenForSubmission:!1,hash:null,slug:"matlab-modelling-programming-and-simulations",bookSignature:"Emilson Pereira Leite",coverURL:"https://cdn.intechopen.com/books/images_new/3737.jpg",editors:[{id:"12051",title:"Prof.",name:"Emilson",middleName:null,surname:"Pereira Leite",slug:"emilson-pereira-leite",fullName:"Emilson Pereira Leite"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"1770",title:"Gel Electrophoresis",subtitle:"Principles and Basics",isOpenForSubmission:!1,hash:"279701f6c802cf02deef45103e0611ff",slug:"gel-electrophoresis-principles-and-basics",bookSignature:"Sameh Magdeldin",coverURL:"https://cdn.intechopen.com/books/images_new/1770.jpg",editors:[{id:"123648",title:"Dr.",name:"Sameh",middleName:null,surname:"Magdeldin",slug:"sameh-magdeldin",fullName:"Sameh Magdeldin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4797},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",publishedDate:"July 27th 2022",numberOfDownloads:7175,editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1981,editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",publishedDate:"July 20th 2022",numberOfDownloads:2308,editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1473,editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",publishedDate:"April 26th 2011",numberOfDownloads:318571,editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",publishedDate:"September 26th 2012",numberOfDownloads:271836,editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",publishedDate:"July 1st 2013",numberOfDownloads:243450,editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",publishedDate:"July 20th 2022",numberOfDownloads:1582,editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",publishedDate:"July 13th 2022",numberOfDownloads:2082,editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",publishedDate:"October 17th 2012",numberOfDownloads:256294,editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11328",title:"Botulinum Toxin",subtitle:"Recent Topics and Applications",isOpenForSubmission:!1,hash:"7dd05a316001cef143e209eda51387a7",slug:"botulinum-toxin-recent-topics-and-applications",bookSignature:"Suna Sabuncuoglu",coverURL:"https://cdn.intechopen.com/books/images_new/11328.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"270856",title:"Associate Prof.",name:"Suna",middleName:null,surname:"Sabuncuoglu",slug:"suna-sabuncuoglu",fullName:"Suna Sabuncuoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11085",title:"Polycystic Ovary Syndrome",subtitle:"Functional Investigation and Clinical Application",isOpenForSubmission:!1,hash:"3066dd3ff29e1fac072fd60b08d4d3e7",slug:"polycystic-ovary-syndrome-functional-investigation-and-clinical-application",bookSignature:"Zhengchao Wang",coverURL:"https://cdn.intechopen.com/books/images_new/11085.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"204883",title:"Dr.",name:"Zhengchao",middleName:null,surname:"Wang",slug:"zhengchao-wang",fullName:"Zhengchao Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10833",title:"Tumor Angiogenesis and Modulators",subtitle:null,isOpenForSubmission:!1,hash:"f29b575c46128b2da061ef7f9bd1070b",slug:"tumor-angiogenesis-and-modulators",bookSignature:"Ke Xu",coverURL:"https://cdn.intechopen.com/books/images_new/10833.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"59529",title:"Dr.",name:"Ke",middleName:null,surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11356",title:"Molecular Cloning",subtitle:null,isOpenForSubmission:!1,hash:"671c629dd86e97f0fb467b9e70e92296",slug:"molecular-cloning",bookSignature:"Sadık Dincer, Hatice Aysun Mercimek Takcı and Melis Sumengen Ozdenef",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"188141",title:"Prof.",name:"Sadik",middleName:null,surname:"Dincer",slug:"sadik-dincer",fullName:"Sadik Dincer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10677",title:"Advanced Topics of Topology",subtitle:null,isOpenForSubmission:!1,hash:"bf964c52f9e653fac20a7fcab58070e5",slug:"advanced-topics-of-topology",bookSignature:"Francisco Bulnes",coverURL:"https://cdn.intechopen.com/books/images_new/10677.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"92918",title:"Dr.",name:"Francisco",middleName:null,surname:"Bulnes",slug:"francisco-bulnes",fullName:"Francisco Bulnes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11195",title:"Recent Advances in Biometrics",subtitle:null,isOpenForSubmission:!1,hash:"2d32e33e0f499cb5241734bb75dd2a83",slug:"recent-advances-in-biometrics",bookSignature:"Muhammad Sarfraz",coverURL:"https://cdn.intechopen.com/books/images_new/11195.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"6",title:"Biochemistry, Genetics and Molecular Biology",slug:"biochemistry-genetics-and-molecular-biology",parent:{id:"2",title:"Life Sciences",slug:"life-sciences"},numberOfBooks:312,numberOfSeries:0,numberOfAuthorsAndEditors:8591,numberOfWosCitations:11955,numberOfCrossrefCitations:6908,numberOfDimensionsCitations:17174,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"6",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"11356",title:"Molecular Cloning",subtitle:null,isOpenForSubmission:!1,hash:"671c629dd86e97f0fb467b9e70e92296",slug:"molecular-cloning",bookSignature:"Sadık Dincer, Hatice Aysun Mercimek Takcı and Melis Sumengen Ozdenef",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg",editedByType:"Edited by",editors:[{id:"188141",title:"Prof.",name:"Sadik",middleName:null,surname:"Dincer",slug:"sadik-dincer",fullName:"Sadik Dincer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10833",title:"Tumor Angiogenesis and Modulators",subtitle:null,isOpenForSubmission:!1,hash:"f29b575c46128b2da061ef7f9bd1070b",slug:"tumor-angiogenesis-and-modulators",bookSignature:"Ke Xu",coverURL:"https://cdn.intechopen.com/books/images_new/10833.jpg",editedByType:"Edited by",editors:[{id:"59529",title:"Dr.",name:"Ke",middleName:null,surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10794",title:"Potassium in Human Health",subtitle:null,isOpenForSubmission:!1,hash:"0fbab5c7b5baa903a6426e7bbd9f99ab",slug:"potassium-in-human-health",bookSignature:"Jie Tang",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",editedByType:"Edited by",editors:[{id:"181267",title:"Dr.",name:"Jie",middleName:null,surname:"Tang",slug:"jie-tang",fullName:"Jie Tang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10797",title:"Cell Culture",subtitle:"Advanced Technology and Applications in Medical and Life Sciences",isOpenForSubmission:!1,hash:"2c628f4757f9639a4450728d839a7842",slug:"cell-culture-advanced-technology-and-applications-in-medical-and-life-sciences",bookSignature:"Xianquan Zhan",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",editedByType:"Edited by",editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10841",title:"Hydrolases",subtitle:null,isOpenForSubmission:!1,hash:"4e868cde273d65a7ff54b1817d640629",slug:"hydrolases",bookSignature:"Sajjad Haider, Adnan Haider and Angel Catalá",coverURL:"https://cdn.intechopen.com/books/images_new/10841.jpg",editedByType:"Edited by",editors:[{id:"110708",title:"Dr.",name:"Sajjad",middleName:null,surname:"Haider",slug:"sajjad-haider",fullName:"Sajjad Haider"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10886",title:"Genetic Polymorphisms",subtitle:"New Insights",isOpenForSubmission:!1,hash:"a71558dd7dfd16ad140168409f887f7e",slug:"genetic-polymorphisms-new-insights",bookSignature:"Mahmut Çalışkan",coverURL:"https://cdn.intechopen.com/books/images_new/10886.jpg",editedByType:"Edited by",editors:[{id:"51528",title:"Prof.",name:"Mahmut",middleName:null,surname:"Çalışkan",slug:"mahmut-caliskan",fullName:"Mahmut Çalışkan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,isOpenForSubmission:!1,hash:"176adcf090fdd1f93cb8ce3146e79ca1",slug:"reactive-oxygen-species",bookSignature:"Rizwan Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",editedByType:"Edited by",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10541",title:"Regulation and Dysfunction of Apoptosis",subtitle:null,isOpenForSubmission:!1,hash:"1d45e84353c25037adb996a7a46c1af1",slug:"regulation-and-dysfunction-of-apoptosis",bookSignature:"Yusuf Tutar",coverURL:"https://cdn.intechopen.com/books/images_new/10541.jpg",editedByType:"Edited by",editors:[{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10746",title:"Prebiotics and Probiotics",subtitle:"From Food to Health",isOpenForSubmission:!1,hash:"3ab2902c0d43605ab43cd0868542db95",slug:"prebiotics-and-probiotics-from-food-to-health",bookSignature:"Elena Franco Robles",coverURL:"https://cdn.intechopen.com/books/images_new/10746.jpg",editedByType:"Edited by",editors:[{id:"219102",title:"Dr.",name:"Elena",middleName:null,surname:"Franco-Robles",slug:"elena-franco-robles",fullName:"Elena Franco-Robles"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",isOpenForSubmission:!1,hash:"8b43add5389ba85743e0a9491e4b9943",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",editedByType:"Edited by",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10745",title:"Nematodes",subtitle:"Recent Advances, Management and New Perspectives",isOpenForSubmission:!1,hash:"975ef07a02e028baac4d50b9f0a733b5",slug:"nematodes-recent-advances-management-and-new-perspectives",bookSignature:"Cristiano and Tiago Edu Kaspary",coverURL:"https://cdn.intechopen.com/books/images_new/10745.jpg",editedByType:"Edited by",editors:[{id:"274523",title:"Dr.",name:"Cristiano",middleName:null,surname:"Bellé",slug:"cristiano-belle",fullName:"Cristiano Bellé"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11021",title:"B-Complex Vitamins",subtitle:"Sources, Intakes and Novel Applications",isOpenForSubmission:!1,hash:"ad50bc292cda8d24f11aef2f5ef88f51",slug:"b-complex-vitamins-sources-intakes-and-novel-applications",bookSignature:"Jean Guy LeBlanc",coverURL:"https://cdn.intechopen.com/books/images_new/11021.jpg",editedByType:"Edited by",editors:[{id:"67023",title:"Dr.",name:"Jean Guy",middleName:null,surname:"LeBlanc",slug:"jean-guy-leblanc",fullName:"Jean Guy LeBlanc"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:312,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"38477",doi:"10.5772/45943",title:"Lipid Peroxidation: Chemical Mechanism, Biological Implications and Analytical Determination",slug:"lipid-peroxidation-chemical-mechanism-biological-implications-and-analytical-determination",totalDownloads:13516,totalCrossrefCites:80,totalDimensionsCites:223,abstract:null,book:{id:"2553",slug:"lipid-peroxidation",title:"Lipid Peroxidation",fullTitle:"Lipid Peroxidation"},signatures:"Marisa Repetto, Jimena Semprine and Alberto Boveris",authors:[{id:"36452",title:"Dr.",name:"Marisa",middleName:"Gabriela",surname:"Repetto",slug:"marisa-repetto",fullName:"Marisa Repetto"}]},{id:"41116",doi:"10.5772/51572",title:"Algal Polysaccharides, Novel Applications and Outlook",slug:"algal-polysaccharides-novel-applications-and-outlook",totalDownloads:14079,totalCrossrefCites:71,totalDimensionsCites:187,abstract:null,book:{id:"2323",slug:"carbohydrates-comprehensive-studies-on-glycobiology-and-glycotechnology",title:"Carbohydrates",fullTitle:"Carbohydrates - Comprehensive Studies on Glycobiology and Glycotechnology"},signatures:"Stefan Kraan",authors:[{id:"142720",title:"Dr.",name:"Stefan",middleName:null,surname:"Kraan",slug:"stefan-kraan",fullName:"Stefan Kraan"}]},{id:"40938",doi:"10.5772/48294",title:"Dehydrogenase Activity in the Soil Environment",slug:"dehydrogenase-activity-in-the-soil-environment",totalDownloads:6940,totalCrossrefCites:72,totalDimensionsCites:182,abstract:null,book:{id:"2524",slug:"dehydrogenases",title:"Dehydrogenases",fullTitle:"Dehydrogenases"},signatures:"Agnieszka Wolińska and Zofia Stępniewska",authors:[{id:"141696",title:"Dr.",name:"Agnieszka",middleName:"Maria",surname:"Wolinska",slug:"agnieszka-wolinska",fullName:"Agnieszka Wolinska"}]},{id:"18396",doi:"10.5772/22331",title:"Salinity Stress and Salt Tolerance",slug:"salinity-stress-and-salt-tolerance",totalDownloads:21995,totalCrossrefCites:56,totalDimensionsCites:161,abstract:null,book:{id:"371",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",title:"Abiotic Stress in Plants",fullTitle:"Abiotic Stress in Plants - Mechanisms and Adaptations"},signatures:"Petronia Carillo, Maria Grazia Annunziata, Giovanni Pontecorvo, Amodio Fuggi and Pasqualina Woodrow",authors:[{id:"47290",title:"Prof.",name:"Giovanni",middleName:null,surname:"Pontecorvo",slug:"giovanni-pontecorvo",fullName:"Giovanni Pontecorvo"},{id:"47803",title:"Dr.",name:"Pasqualina",middleName:null,surname:"Woodrow",slug:"pasqualina-woodrow",fullName:"Pasqualina Woodrow"},{id:"47804",title:"Prof.",name:"Petronia",middleName:null,surname:"Carillo",slug:"petronia-carillo",fullName:"Petronia Carillo"},{id:"47808",title:"Prof.",name:"Amodio",middleName:null,surname:"Fuggi",slug:"amodio-fuggi",fullName:"Amodio Fuggi"},{id:"47809",title:"Dr.",name:"Maria Grazia",middleName:null,surname:"Annunziata",slug:"maria-grazia-annunziata",fullName:"Maria Grazia Annunziata"}]},{id:"57644",doi:"10.5772/intechopen.71570",title:"Polysaccharides: Structure and Solubility",slug:"polysaccharides-structure-and-solubility",totalDownloads:4480,totalCrossrefCites:41,totalDimensionsCites:121,abstract:"Understanding the solubility of polysaccharides is extremely important for their food applications as most functions of polysaccharides including stability, emulsifying property, drug delivery, membrane forming properties, etc., are all achieved in aqueous solution. This chapter aims specifically at the mechanism of solubility of polysaccharides from the molecular level. General understandings of the solubility including definition, testing methods, and the solution behaviors were provided; the relationships between polysaccharide solubility and the structural features in terms of molecular weight, degree of branching, charging properties, chain flexibility, and the special groups were all discussed. With all the information provided, the molecular modification and further applications of polysaccharides in both food and nonfood areas could be promoted.",book:{id:"5935",slug:"solubility-of-polysaccharides",title:"Solubility of Polysaccharides",fullTitle:"Solubility of Polysaccharides"},signatures:"Mark Q. Guo, Xinzhong Hu, Changlu Wang and Lianzhong Ai",authors:[{id:"202384",title:"Dr.",name:"Qingbin",middleName:null,surname:"Guo",slug:"qingbin-guo",fullName:"Qingbin Guo"},{id:"203883",title:"Dr.",name:"Changlu",middleName:null,surname:"Wang",slug:"changlu-wang",fullName:"Changlu Wang"},{id:"203884",title:"Prof.",name:"Xinzhong",middleName:null,surname:"Hu",slug:"xinzhong-hu",fullName:"Xinzhong Hu"}]}],mostDownloadedChaptersLast30Days:[{id:"69775",title:"Principles of Chromatography Method Development",slug:"principles-of-chromatography-method-development",totalDownloads:4293,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"This chapter aims to explain the key parameters of analytical method development using the chromatography techniques which are used for the identification, separation, purification, and quantitative estimation of complex mixtures of organic compounds. Mainly, the versatile techniques of ultra−/high-performance liquid chromatography (UPLC/HPLC) are in use for the analysis of assay and organic impurities/related substances/degradation products of a drug substance or drug product or intermediate or raw material of pharmaceuticals. A suitable analytical method is developed only after evaluating the major and critical separation parameters of chromatography (examples for UPLC/HPLC are selection of diluent, wavelength, detector, stationary phase, column temperature, flow rate, solvent system, elution mode, and injection volume, etc.). The analytical method development is a process of proving the developed analytical method is suitable for its intended use for the quantitative estimation of the targeted analyte present in pharmaceutical drugs. And it mostly plays a vital role in the development and manufacture of pharmaceuticals drugs.",book:{id:"8912",slug:"biochemical-analysis-tools-methods-for-bio-molecules-studies",title:"Biochemical Analysis Tools",fullTitle:"Biochemical Analysis Tools - Methods for Bio-Molecules Studies"},signatures:"Narasimha S. Lakka and Chandrasekar Kuppan",authors:[{id:"304950",title:"Prof.",name:"Chandrasekar",middleName:null,surname:"Kuppan",slug:"chandrasekar-kuppan",fullName:"Chandrasekar Kuppan"},{id:"309984",title:"Mr.",name:"Narasimha S",middleName:null,surname:"Lakka",slug:"narasimha-s-lakka",fullName:"Narasimha S Lakka"}]},{id:"33046",title:"Affinity Chromatography: Principles and Applications",slug:"affinity-chromatography-principles-and-applications",totalDownloads:48679,totalCrossrefCites:8,totalDimensionsCites:21,abstract:null,book:{id:"1490",slug:"affinity-chromatography",title:"Affinity Chromatography",fullTitle:"Affinity Chromatography"},signatures:"Sameh Magdeldin and Annette Moser",authors:[{id:"123648",title:"Dr.",name:"Sameh",middleName:null,surname:"Magdeldin",slug:"sameh-magdeldin",fullName:"Sameh Magdeldin"},{id:"136483",title:"Dr.",name:"Annette",middleName:"C.",surname:"Moser",slug:"annette-moser",fullName:"Annette Moser"}]},{id:"50574",title:"Bioinformatics for RNA‐Seq Data Analysis",slug:"bioinformatics-for-rna-seq-data-analysis",totalDownloads:6047,totalCrossrefCites:6,totalDimensionsCites:7,abstract:"While RNA sequencing (RNA‐seq) has become increasingly popular for transcriptome profiling, the analysis of the massive amount of data generated by large‐scale RNA‐seq still remains a challenge. RNA‐seq data analyses typically consist of (1) accurate mapping of millions of short sequencing reads to a reference genome, including the identification of splicing events; (2) quantifying expression levels of genes, transcripts, and exons; (3) differential analysis of gene expression among different biological conditions; and (4) biological interpretation of differentially expressed genes. Despite the fact that multiple algorithms pertinent to basic analyses have been developed, there are still a variety of unresolved questions. In this chapter, we review the main tools and algorithms currently available for RNA‐seq data analyses, and our goal is to help RNA‐seq data analysts to make an informed choice of tools in practical RNA‐seq data analysis. In the meantime, RNA‐seq is evolving rapidly, and newer sequencing technologies are briefly introduced, including stranded RNA‐seq, targeted RNA‐seq, and single‐cell RNA‐seq.",book:{id:"5160",slug:"bioinformatics-updated-features-and-applications",title:"Bioinformatics",fullTitle:"Bioinformatics - Updated Features and Applications"},signatures:"Shanrong Zhao, Baohong Zhang, Ying Zhang, William Gordon,\nSarah Du, Theresa Paradis, Michael Vincent and David von Schack",authors:[{id:"176364",title:"Dr.",name:"Shanrong",middleName:null,surname:"Zhao",slug:"shanrong-zhao",fullName:"Shanrong Zhao"}]},{id:"49873",title:"An Introduction to Actinobacteria",slug:"an-introduction-to-actinobacteria",totalDownloads:8178,totalCrossrefCites:33,totalDimensionsCites:108,abstract:"Actinobacteria, which share the characteristics of both bacteria and fungi, are widely distributed in both terrestrial and aquatic ecosystems, mainly in soil, where they play an essential role in recycling refractory biomaterials by decomposing complex mixtures of polymers in dead plants and animals and fungal materials. They are considered as the biotechnologically valuable bacteria that are exploited for its secondary metabolite production. Approximately, 10,000 bioactive metabolites are produced by Actinobacteria, which is 45% of all bioactive microbial metabolites discovered. Especially Streptomyces species produce industrially important microorganisms as they are a rich source of several useful bioactive natural products with potential applications. Though it has various applications, some Actinobacteria have its own negative effect against plants, animals, and humans. On this context, this chapter summarizes the general characteristics of Actinobacteria, its habitat, systematic classification, various biotechnological applications, and negative impact on plants and animals.",book:{id:"5056",slug:"actinobacteria-basics-and-biotechnological-applications",title:"Actinobacteria",fullTitle:"Actinobacteria - Basics and Biotechnological Applications"},signatures:"Ranjani Anandan, Dhanasekaran Dharumadurai and Gopinath\nPonnusamy Manogaran",authors:[{id:"48914",title:"Dr.",name:"Dharumadurai",middleName:null,surname:"Dhanasekaran",slug:"dharumadurai-dhanasekaran",fullName:"Dharumadurai Dhanasekaran"}]},{id:"72074",title:"The Chemistry Behind Plant DNA Isolation Protocols",slug:"the-chemistry-behind-plant-dna-isolation-protocols",totalDownloads:3797,totalCrossrefCites:4,totalDimensionsCites:7,abstract:"Various plant species are biochemically heterogeneous in nature, a single deoxyribose nucleic acid (DNA) isolation protocol may not be suitable. There have been continuous modification and standardization in DNA isolation protocols. Most of the plant DNA isolation protocols used today are modified versions of hexadecyltrimethyl-ammonium bromide (CTAB) extraction procedure. Modification is usually performed in the concentration of chemicals used during the extraction procedure according to the plant species and plant part used. Thus, understanding the role of each chemical (viz. CTAB, NaCl, PVP, ethanol, and isopropanol) used during the DNA extraction procedure will benefit to set or modify protocols for more precisions. A review of the chemicals used in the CTAB method of DNA extraction and their probable functions on the highly evolved yet complex to students and researchers has been summarized.",book:{id:"8912",slug:"biochemical-analysis-tools-methods-for-bio-molecules-studies",title:"Biochemical Analysis Tools",fullTitle:"Biochemical Analysis Tools - Methods for Bio-Molecules Studies"},signatures:"Jina Heikrujam, Rajkumar Kishor and Pranab Behari Mazumder",authors:[{id:"74521",title:"Dr.",name:"Rajkumar",middleName:null,surname:"Kishor",slug:"rajkumar-kishor",fullName:"Rajkumar Kishor"},{id:"309357",title:"Prof.",name:"Pranab Behari",middleName:null,surname:"Mazumder",slug:"pranab-behari-mazumder",fullName:"Pranab Behari Mazumder"},{id:"318351",title:"Ph.D. Student",name:"Jina",middleName:null,surname:"Heikrujam",slug:"jina-heikrujam",fullName:"Jina Heikrujam"}]}],onlineFirstChaptersFilter:{topicId:"6",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"83043",title:"Applications of CRISPR/Cas9 for Selective Sequencing and Clinical Diagnostics",slug:"applications-of-crispr-cas9-for-selective-sequencing-and-clinical-diagnostics",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.106548",abstract:"In this chapter, we will discuss the applications of CRISPR/Cas9 in the context of clinical diagnostics. We will provide an overview of existing methods and their use cases in the diagnostic field. Special attention will be given to selective sequencing approaches using third-generation sequencing and PAM-site requirements. As target sequences in an AT-rich environment cannot easily be accessed by the commercially available SpCas9 due to rarity of NGG PAM-sites, new enzymes such as ScCas9 with PAM-site requirements of NNG will be highlighted. Original research on CRISPR/Cas9 systems to determine molecular glioma markers by enriching regions of interest will be discussed in the context of potential future applications in clinical diagnostics.",book:{id:"11804",title:"CRISPR Technology",coverURL:"https://cdn.intechopen.com/books/images_new/11804.jpg"},signatures:"Maximilian Evers, Björn Brändl, Franz-Josef Müller, Sönke Friedrichsen and Stephan Kolkenbrock"},{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.105049",abstract:"In this chapter, we will discuss the importance of genetic variations in the IL-23 receptor (IL-23R) gene in driving the process of inflammation-induced carcinogenesis. By applying bladder cancer (BLC) as a model, we will focus on two contradictory genetic mutations within the receptor gene. The first one is enhanced by cancer and induces inflammation-induced carcinogenesis via up-regulating IL-23/IL-17 inflammatory axis. However, the other preventive one deregulates this inflammatory pathway by distorting the protein nature of the receptor, leading to block its binding affinity. During the process of carcinogenesis, cancer genetically inclines the balance towards the protumor, via over-expressing the IL-23R on the surfaces of immune-bearing cells, particularly tumor-associated monocytes (TAMs) and thus increasing the levels of pro-angiogenic cytokines IL-23 and IL-17.",book:{id:"11672",title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg"},signatures:"Mohammed El-Gedamy"},{id:"82259",title:"p53 Tumor Suppressor: Functional Regulation and Role in Gene Therapy",slug:"p53-tumor-suppressor-functional-regulation-and-role-in-gene-therapy",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.105029",abstract:"p53, a homo-tetrameric protein found in mammalian cells, derives its name from the fact that it settles at around 53KDa position in SDS-PAGE, due to a “kink” in its structure. In its functional state, p53 forms a homo-tetramer and binds to the promoters of a wide array of genes. Binding of p53 downregulates the transcription of target genes. Most of the gene targets of p53 are involved in cell cycle progression, and therefore, any malfunctions associated with p53 have catastrophic consequences for the cell. The gene encoding for p53 known as TP53 is the most well-studied gene in the entire genome because of being the most highly mutated gene in all cancer types. It is due to this widely accepted and documented “cell protective feature” that p53 is generally referred to as “the guardian of the genome.” In this chapter, we will discuss the involvement of p53 in relation to carcinogenesis. We will also cover the major functions of p53 under normal conditions, major mutations of the TP53 gene, and their association with different forms of cancer.",book:{id:"10246",title:"P53 - A Guardian of the Genome and Beyond",coverURL:"https://cdn.intechopen.com/books/images_new/10246.jpg"},signatures:"Zeenat Farooq, Shahnawaz Wani, Vijay Avin BR, Rakesh Kochhar and Mumtaz Anwar"},{id:"82875",title:"Lipidomics as a Tool in the Diagnosis and Clinical Therapy",slug:"lipidomics-as-a-tool-in-the-diagnosis-and-clinical-therapy",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.105857",abstract:"The lipids are essential compounds of cells, with biochemical and structural properties. Lipids are classified according to their chain length or saturation levels and biogenesis. Lipidomics is a spectroscopic and spectrometric technique, like Mass Spectrometry and Nuclear Magnetic Resonance, as well as bioinformatics to quantify and characterize the lipid profile. Lipidomics enables the fundamental understanding of lipid biology, the identification of drug targets for therapy, and the discovery of lipid biomarkers of disease cohorts. Therefore, lipidomics allows knowing the diagnosis and clinical follow-up in medical therapy towards any disease. In this way, the lipid profile allows us to monitor the administration of a clinical treatment and assertively diagnose human diseases.",book:{id:"11669",title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg"},signatures:"María Elizbeth Alvarez Sánchez, Erick Nolasco Ontiveros, Rodrigo Arreola, Adriana Montserrat Espinosa González, Ana María García Bores, Roberto Eduardo López Urrutia, Ignacio Peñalosa Castro, María del Socorro Sánchez Correa and Edgar Antonio Estrella Parra"},{id:"82862",title:"Assessment of Genetic Variability of Three Types of Sorghum Cultivated in Burkina Faso Using Morphoagronomic Quantitative Traits and Brix",slug:"assessment-of-genetic-variability-of-three-types-of-sorghum-cultivated-in-burkina-faso-using-morphoa",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.105984",abstract:"In Burkina Faso, tree types of sorghum are mainly grown. Despite their genetic proximity revealed by molecular markers, the identification of distinctive agro-morphological traits between sweet grain sorghum, sweet sorghum and grain sorghum could contribute to better management of their genetic resources. Thus, 42 genotypes consisting of the three sorghum types were evaluated in a three replicate Fisher incomplete block design using 20 quantitative traits. The results showed a high variability of traits within each sorghum type and a greater closeness between sweet grain sorghum and sweet stalk sorghum. In addition, nine traits clearly discriminated sweet grain sorghum from the other sorghum types. Sweet grain sorghum expressed the highest values of the sowing-heading cycle, leaf sheath length, stem diameter, productive tillers, and panicle width and the lowest values of mean heading-flowering difference, 100-grain weight, and Brix. Moreover, the ‘sorghum type’ factor is less preponderant than the ‘genotype factor’ in expressing the variability of all traits. Therefore, the 42 genotypes are organized into three genetic groups independently of the sorghum- type factor, where the group I contains all sweet grain sorghum genotypes and three sweet stalk sorghum genotypes. These results could be exploited in sorghum breeding programs.",book:{id:"11643",title:"Genetic Diversity - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11643.jpg"},signatures:"Nerbéwendé Sawadogo, Mahamadi Hamed Ouédraogo, Lardia Ali Bougma, Norbert Yaméogo, Wendmanegda Hermann Tondé, Josiane Tiendrébéogo, Sévérin Tuina, Gapili Naoura and Mahamadou Sawadogo"},{id:"82440",title:"Lipid Metabolism and Associated Molecular Signaling Events in Autoimmune Disease",slug:"lipid-metabolism-and-associated-molecular-signaling-events-in-autoimmune-disease",totalDownloads:17,totalDimensionsCites:0,doi:"10.5772/intechopen.105746",abstract:"Lipid metabolism, when dysregulated paves the way to many autoimmune disease conditions. One such recently explored mechanism was that of Liver X receptor (LXR) signaling which acts as a molecular link between lipid metabolism and inflammation. LXR plays a critical role in coupling immune cell lipid homeostasis with systemic immune responses. In this chapter, we will discuss how an altered lipid metabolite environment causes inflammation signaling via LXR-mediated molecular events which could lead to autoimmune disease. In a hyperlipidemic environment, Interferon regulatory factor 3(IRF3) mediated downregulation of LXR signaling in innate immune cells leading to an inflammatory auto-immune response. Meanwhile, dendritic cell-mediated cytokine generation amidst LXR downregulation leads to the differentiation of autoreactive T cells and B cells, conferring an autoimmune response. Recent advances in the therapeutic management of autoimmune diseases target specific metabolic events as a strategy to limit inflammation and the autoimmune outcome. Novel treatment regimes in autoimmune diseases featuring lipid metabolic pathways are also discussed.",book:{id:"11669",title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg"},signatures:"Mohan Vanditha, Sonu Das and Mathew John"}],onlineFirstChaptersTotal:91},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. By addressing hot topics in veterinary sciences, we aim to gather authoritative texts within each issue of this series, providing in-depth overviews and analysis for graduates, academics, and practitioners and foreseeing a deeper understanding of the subject. Forthcoming texts, written and edited by experienced researchers from both industry and academia, will also discuss scientific challenges faced today in Veterinary Medicine and Science. In brief, we hope that books in this series will provide accessible references for those interested or working in this field and encourage learning in a range of different topics.",coverUrl:"https://cdn.intechopen.com/series/covers/13.jpg",latestPublicationDate:"August 7th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",isOpenForSubmission:!0,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). She is the head of the Reproduction and Embryology Laboratories and was lecturer of Reproduction and Reproductive Biotechnologies at Veterinary Medicine Faculty. She has over 25 years of experience working in reproductive biology and biotechnology areas with a special emphasis on embryo and gamete cryopreservation, for research and animal genetic resources conservation, leading research projects with several peer-reviewed papers. Rosa Pereira is member of the ERFP-FAO Ex situ Working Group and of the Management Commission of the Portuguese Animal Germplasm Bank.",institutionString:"The National Institute for Agricultural and Veterinary Research. Portugal",institution:null},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:20,paginationItems:[{id:"82991",title:"Diseases of the Canine Prostate Gland",doi:"10.5772/intechopen.105835",signatures:"Sabine Schäfer-Somi",slug:"diseases-of-the-canine-prostate-gland",totalDownloads:0,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82956",title:"Potential Substitutes of Antibiotics for Swine and Poultry Production",doi:"10.5772/intechopen.106081",signatures:"Ho Trung Thong, Le Nu Anh Thu and Ho Viet Duc",slug:"potential-substitutes-of-antibiotics-for-swine-and-poultry-production",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"82905",title:"A Review of Application Strategies and Efficacy of Probiotics in Pet Food",doi:"10.5772/intechopen.105829",signatures:"Heather Acuff and Charles G. Aldrich",slug:"a-review-of-application-strategies-and-efficacy-of-probiotics-in-pet-food",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"82773",title:"Canine Transmissible Venereal Tumor: An Infectious Neoplasia in Dogs",doi:"10.5772/intechopen.106150",signatures:"Chanokchon Setthawongsin, Somporn Techangamsuwan and Anudep Rungsipipat",slug:"canine-transmissible-venereal-tumor-an-infectious-neoplasia-in-dogs",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}}]},overviewPagePublishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"7233",title:"New Insights into Theriogenology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7233.jpg",slug:"new-insights-into-theriogenology",publishedDate:"December 5th 2018",editedByType:"Edited by",bookSignature:"Rita Payan-Carreira",hash:"74f4147e3fb214dd050e5edd3aaf53bc",volumeInSeries:1,fullTitle:"New Insights into Theriogenology",editors:[{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}]},{type:"book",id:"7144",title:"Veterinary Anatomy and Physiology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",slug:"veterinary-anatomy-and-physiology",publishedDate:"March 13th 2019",editedByType:"Edited by",bookSignature:"Catrin Sian Rutland and Valentina Kubale",hash:"75cdacb570e0e6d15a5f6e69640d87c9",volumeInSeries:2,fullTitle:"Veterinary Anatomy and Physiology",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}]},{type:"book",id:"8524",title:"Lactation in Farm Animals",subtitle:"Biology, Physiological Basis, Nutritional Requirements, and Modelization",coverURL:"https://cdn.intechopen.com/books/images_new/8524.jpg",slug:"lactation-in-farm-animals-biology-physiological-basis-nutritional-requirements-and-modelization",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Naceur M'Hamdi",hash:"2aa2a9a0ec13040bbf0455e34625504e",volumeInSeries:3,fullTitle:"Lactation in Farm Animals - Biology, Physiological Basis, Nutritional Requirements, and Modelization",editors:[{id:"73376",title:"Dr.",name:"Naceur",middleName:null,surname:"M'Hamdi",slug:"naceur-m'hamdi",fullName:"Naceur M'Hamdi",profilePictureURL:"https://mts.intechopen.com/storage/users/73376/images/system/73376.jpg",biography:"Naceur M’HAMDI is Associate Professor at the National Agronomic Institute of Tunisia, University of Carthage. He is also Member of the Laboratory of genetic, animal and feed resource and member of Animal science Department of INAT. He graduated from Higher School of Agriculture of Mateur, University of Carthage, in 2002 and completed his masters in 2006. Dr. M’HAMDI completed his PhD thesis in Genetic welfare indicators of dairy cattle at Higher Institute of Agronomy of Chott-Meriem, University of Sousse, in 2011. He worked as assistant Professor of Genetic, biostatistics and animal biotechnology at INAT since 2013.",institutionString:null,institution:null}]},{type:"book",id:"8460",title:"Reproductive Biology and Technology in Animals",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8460.jpg",slug:"reproductive-biology-and-technology-in-animals",publishedDate:"April 15th 2020",editedByType:"Edited by",bookSignature:"Juan Carlos Gardón Poggi and Katy Satué Ambrojo",hash:"32ef5fe73998dd723d308225d756fa1e",volumeInSeries:4,fullTitle:"Reproductive Biology and Technology in Animals",editors:[{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",institutionURL:null,country:{name:"Spain"}}}]}]},openForSubmissionBooks:{paginationCount:2,paginationItems:[{id:"12086",title:"Cattle Diseases - Molecular and Biochemical Approach",coverURL:"https://cdn.intechopen.com/books/images_new/12086.jpg",hash:"afdbf57e32d996556a94528c06623cf3",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 5th 2022",isOpenForSubmission:!0,editors:[{id:"219081",title:"Dr.",name:"Abdulsamed",surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11579",title:"Animal Welfare - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11579.jpg",hash:"12e4f41264cbe99028655e5463fa941a",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 8th 2022",isOpenForSubmission:!0,editors:[{id:"51520",title:"Dr.",name:"Shao-Wen",surname:"Hung",slug:"shao-wen-hung",fullName:"Shao-Wen Hung"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:11,paginationItems:[{id:"83075",title:"Practices and Challenges of Community Services at Debre Markos University, Ethiopia: A Case Study",doi:"10.5772/intechopen.105896",signatures:"Adane Mengist",slug:"practices-and-challenges-of-community-services-at-debre-markos-university-ethiopia-a-case-study",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82858",title:"Corporate Social Responsibility a Case of the Provision of Recreational Facilities",doi:"10.5772/intechopen.105608",signatures:"Peter Musa Wash, Shida Irwana Omar, Badaruddin Mohamed and Mohd Ismail Isa",slug:"corporate-social-responsibility-a-case-of-the-provision-of-recreational-facilities",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82786",title:"Discussion of Purchasing Virtual Digital Nature and Tourism",doi:"10.5772/intechopen.105869",signatures:"Hiroko Oe and Yasuyuki Yamaoka",slug:"discussion-of-purchasing-virtual-digital-nature-and-tourism",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"A New Era of Consumer Behavior - Beyond the Pandemic",coverURL:"https://cdn.intechopen.com/books/images_new/11581.jpg",subseries:{id:"88",title:"Marketing"}}},{id:"82289",title:"Consumer Culture and Abundance of Choices: Having More, Feeling Blue",doi:"10.5772/intechopen.105607",signatures:"Ondřej Roubal",slug:"consumer-culture-and-abundance-of-choices-having-more-feeling-blue",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"A New Era of Consumer Behavior - Beyond the Pandemic",coverURL:"https://cdn.intechopen.com/books/images_new/11581.jpg",subseries:{id:"88",title:"Marketing"}}},{id:"82405",title:"Does Board Structure Matter in CSR Spending of Commercial Banks? Empirical Evidence from an Emerging Economy",doi:"10.5772/intechopen.105589",signatures:"Bishnu Kumar Adhikary and Ranjan Kumar Mitra",slug:"does-board-structure-matter-in-csr-spending-of-commercial-banks-empirical-evidence-from-an-emerging-",totalDownloads:18,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82395",title:"Toward a Better Understanding of Green Human Resource Management’s Impact on Green Competitive Advantage: A Conceptual Model",doi:"10.5772/intechopen.105528",signatures:"Hosna Hossari and Kaoutar Elfahli",slug:"toward-a-better-understanding-of-green-human-resource-management-s-impact-on-green-competitive-advan",totalDownloads:27,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82269",title:"CSR Reporting and Blockchain Technology",doi:"10.5772/intechopen.105512",signatures:"Pattarake Sarajoti, Pattanaporn Chatjuthamard, Suwongrat Papangkorn and Piyachart Phiromswad",slug:"csr-reporting-and-blockchain-technology",totalDownloads:31,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82270",title:"From Corporate Social Opportunity to Corporate Social Responsibility",doi:"10.5772/intechopen.105445",signatures:"Brian Bolton",slug:"from-corporate-social-opportunity-to-corporate-social-responsibility",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82339",title:"Green Human Resource Management: An Exploratory Study from Moroccan ISO 14001 Certified Companies",doi:"10.5772/intechopen.105565",signatures:"Hosna Hossari and Kaoutar Elfahli",slug:"green-human-resource-management-an-exploratory-study-from-moroccan-iso-14001-certified-companies",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82194",title:"CSR and Female Directors: A Review and Future Research Agenda",doi:"10.5772/intechopen.105112",signatures:"Pattarake Sarajoti, Pattanaporn Chatjuthamard, Suwongrat Papangkorn and Sirimon Treepongkaruna",slug:"csr-and-female-directors-a-review-and-future-research-agenda",totalDownloads:18,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}}]},subseriesFiltersForOFChapters:[{caption:"Marketing",value:88,count:2,group:"subseries"},{caption:"Business and Management",value:86,count:9,group:"subseries"}],publishedBooks:{paginationCount:12,paginationItems:[{type:"book",id:"9883",title:"Biosensors",subtitle:"Current and Novel Strategies for Biosensing",coverURL:"https://cdn.intechopen.com/books/images_new/9883.jpg",slug:"biosensors-current-and-novel-strategies-for-biosensing",publishedDate:"May 5th 2021",editedByType:"Edited by",bookSignature:"Luis Jesús Villarreal-Gómez and Ana Leticia Iglesias",hash:"028f3e5dbf9c32590183ac4b4f0a2825",volumeInSeries:11,fullTitle:"Biosensors - Current and Novel Strategies for Biosensing",editors:[{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9959",title:"Biomedical Signal and Image Processing",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9959.jpg",slug:"biomedical-signal-and-image-processing",publishedDate:"April 14th 2021",editedByType:"Edited by",bookSignature:"Yongxia Zhou",hash:"22b87a09bd6df065d78c175235d367c8",volumeInSeries:10,fullTitle:"Biomedical Signal and Image Processing",editors:[{id:"259308",title:"Dr.",name:"Yongxia",middleName:null,surname:"Zhou",slug:"yongxia-zhou",fullName:"Yongxia Zhou",profilePictureURL:"https://mts.intechopen.com/storage/users/259308/images/system/259308.jpeg",institutionString:"University of Southern California",institution:{name:"University of Southern California",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9973",title:"Data Acquisition",subtitle:"Recent Advances and Applications in Biomedical Engineering",coverURL:"https://cdn.intechopen.com/books/images_new/9973.jpg",slug:"data-acquisition-recent-advances-and-applications-in-biomedical-engineering",publishedDate:"March 17th 2021",editedByType:"Edited by",bookSignature:"Bartłomiej Płaczek",hash:"75ea6cdd241216c9db28aa734ab34446",volumeInSeries:9,fullTitle:"Data Acquisition - Recent Advances and Applications in Biomedical Engineering",editors:[{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",institutionString:"University of Silesia",institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9905",title:"Biometric Systems",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9905.jpg",slug:"biometric-systems",publishedDate:"February 10th 2021",editedByType:"Edited by",bookSignature:"Muhammad Sarfraz",hash:"c730560dd2e3837a03407b3a86b0ef2a",volumeInSeries:8,fullTitle:"Biometric Systems",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",institutionString:"Kuwait University",institution:{name:"Kuwait University",institutionURL:null,country:{name:"Kuwait"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8622",title:"Peptide Synthesis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8622.jpg",slug:"peptide-synthesis",publishedDate:"December 18th 2019",editedByType:"Edited by",bookSignature:"Jaya T. Varkey",hash:"de9fa48c5248dbfb581825b8c74f5623",volumeInSeries:0,fullTitle:"Peptide Synthesis",editors:[{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",institutionString:"St. Teresa’s College",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7497",title:"Computer Vision in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7497.jpg",slug:"computer-vision-in-dentistry",publishedDate:"September 18th 2019",editedByType:"Edited by",bookSignature:"Monika Elzbieta Machoy",hash:"1e9812cebd46ef9e28257f3e96547f6a",volumeInSeries:7,fullTitle:"Computer Vision in Dentistry",editors:[{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8633",title:"Novel Diagnostic Methods in Ophthalmology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8633.jpg",slug:"novel-diagnostic-methods-in-ophthalmology",publishedDate:"September 4th 2019",editedByType:"Edited by",bookSignature:"Anna Nowinska",hash:"da2c90e8db647ead30504defce3fb5d3",volumeInSeries:6,fullTitle:"Novel Diagnostic Methods in Ophthalmology",editors:[{id:"261466",title:"Dr.",name:"Anna",middleName:"Karolina",surname:"Nowińska",slug:"anna-nowinska",fullName:"Anna Nowińska",profilePictureURL:"https://mts.intechopen.com/storage/users/261466/images/system/261466.jpeg",institutionString:"Medical University of Silesia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7437",title:"Nanomedicines",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7437.jpg",slug:"nanomedicines",publishedDate:"February 13th 2019",editedByType:"Edited by",bookSignature:"Muhammad Akhyar Farrukh",hash:"0e1f5f6258f074c533976c4f4d248568",volumeInSeries:5,fullTitle:"Nanomedicines",editors:[{id:"63182",title:"Dr.",name:"Muhammad Akhyar",middleName:null,surname:"Farrukh",slug:"muhammad-akhyar-farrukh",fullName:"Muhammad Akhyar Farrukh",profilePictureURL:"https://mts.intechopen.com/storage/users/63182/images/system/63182.png",institutionString:"Forman Christian College",institution:{name:"Forman Christian College",institutionURL:null,country:{name:"Pakistan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6843",title:"Biomechanics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6843.jpg",slug:"biomechanics",publishedDate:"January 30th 2019",editedByType:"Edited by",bookSignature:"Hadi Mohammadi",hash:"85132976010be1d7f3dbd88662b785e5",volumeInSeries:4,fullTitle:"Biomechanics",editors:[{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",institutionString:"University of Silesia",institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6692",title:"Medical and Biological Image Analysis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6692.jpg",slug:"medical-and-biological-image-analysis",publishedDate:"July 4th 2018",editedByType:"Edited by",bookSignature:"Robert Koprowski",hash:"e75f234a0fc1988d9816a94e4c724deb",volumeInSeries:1,fullTitle:"Medical and Biological Image Analysis",editors:[{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",value:9,count:1},{group:"subseries",caption:"Bioinspired Technology and Biomechanics",value:8,count:2},{group:"subseries",caption:"Bioinformatics and Medical Informatics",value:7,count:9}],publicationYearFilters:[{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:3}],authors:{paginationCount:754,paginationItems:[{id:"310674",title:"Dr.",name:"Pravin",middleName:null,surname:"Kendrekar",slug:"pravin-kendrekar",fullName:"Pravin Kendrekar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310674/images/system/310674.jpg",biography:"Dr. Pravin Kendrekar, MSc, MBA, Ph.D., is currently a visiting scientist at the Lipid Nanostructure Laboratory, University of Central Lancashire, England. He previously worked as a post-doctoral fellow at the Ben-Gurion University of Negev, Israel; University of the Free State, South Africa; and Central University of Technology Bloemfontein, South Africa. He obtained his Ph.D. in Organic Chemistry from Nagaoka University of Technology, Japan. He has published more than seventy-four journal articles and attended several national and international conferences as speaker and chair. Dr. Kendrekar has received many international awards. He has several funded projects, namely, anti-malaria drug development, MRSA, and SARS-CoV-2 activity of curcumin and its formulations. He has filed four patents in collaboration with the University of Central Lancashire and Mayo Clinic Infectious Diseases. His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"10",type:"subseries",title:"Animal Physiology",keywords:"Physiology, Comparative, Evolution, Biomolecules, Organ, Homeostasis, Anatomy, Pathology, Medical, Cell Division, Cell Signaling, Cell Growth, Cell Metabolism, Endocrine, Neuroscience, Cardiovascular, Development, Aging, Development",scope:"Physiology, the scientific study of functions and mechanisms of living systems, is an essential area of research in its own right, but also in relation to medicine and health sciences. The scope of this topic will range from molecular, biochemical, cellular, and physiological processes in all animal species. Work pertaining to the whole organism, organ systems, individual organs and tissues, cells, and biomolecules will be included. Medical, animal, cell, and comparative physiology and allied fields such as anatomy, histology, and pathology with physiology links will be covered in this topic. Physiology research may be linked to development, aging, environment, regular and pathological processes, adaptation and evolution, exercise, or several other factors affecting, or involved with, animal physiology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",hasOnlineFirst:!1,hasPublishedBooks:!1,annualVolume:11406,editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"306970",title:"Mr.",name:"Amin",middleName:null,surname:"Tamadon",slug:"amin-tamadon",fullName:"Amin Tamadon",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002oHR5wQAG/Profile_Picture_1623910304139",institutionString:null,institution:{name:"Bushehr University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",institutionURL:null,country:{name:"Spain"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",institutionString:null,institution:{name:"Miguel Hernandez University",institutionURL:null,country:{name:"Spain"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",institutionString:null,institution:{name:"Alexandria University",institutionURL:null,country:{name:"Egypt"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",institutionString:"Kafkas University",institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"82380",title:"Evolution of Parasitism and Pathogenic Adaptations in Certain Medically Important Fungi",doi:"10.5772/intechopen.105206",signatures:"Gokul Shankar Sabesan, Ranjit Singh AJA, Ranjith Mehenderkar and Basanta Kumar Mohanty",slug:"evolution-of-parasitism-and-pathogenic-adaptations-in-certain-medically-important-fungi",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fungal Infectious Diseases - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11400.jpg",subseries:{id:"4",title:"Fungal Infectious Diseases"}}}]},publishedBooks:{paginationCount:3,paginationItems:[{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",publishedDate:"July 27th 2022",editedByType:"Edited by",bookSignature:"Dragana Gabrić and Marko Vuletić",hash:"4af8830e463f89c57515c2da2b9777b0",volumeInSeries:11,fullTitle:"Current Concepts in Dental Implantology - From Science to Clinical Research",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić",profilePictureURL:"https://mts.intechopen.com/storage/users/26946/images/system/26946.png",institutionString:"University of Zagreb",institution:{name:"University of Zagreb",institutionURL:null,country:{name:"Croatia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7572",title:"Trauma in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7572.jpg",slug:"trauma-in-dentistry",publishedDate:"July 3rd 2019",editedByType:"Edited by",bookSignature:"Serdar Gözler",hash:"7cb94732cfb315f8d1e70ebf500eb8a9",volumeInSeries:3,fullTitle:"Trauma in Dentistry",editors:[{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7139",title:"Current Approaches in Orthodontics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7139.jpg",slug:"current-approaches-in-orthodontics",publishedDate:"April 10th 2019",editedByType:"Edited by",bookSignature:"Belma Işık Aslan and Fatma Deniz Uzuner",hash:"2c77384eeb748cf05a898d65b9dcb48a",volumeInSeries:2,fullTitle:"Current Approaches in Orthodontics",editors:[{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"August 3rd, 2022",hasOnlineFirst:!0,numberOfOpenTopics:3,numberOfPublishedChapters:107,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",fullName:"Reda R. Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. Osma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDv7QAG/Profile_Picture_1626602531691",institutionString:null,institution:{name:"Universidad de Los Andes",institutionURL:null,country:{name:"Colombia"}}},{id:"69697",title:"Dr.",name:"Mani T.",middleName:null,surname:"Valarmathi",fullName:"Mani T. Valarmathi",profilePictureURL:"https://mts.intechopen.com/storage/users/69697/images/system/69697.jpg",institutionString:"Religen Inc. | A Life Science Company, United States of America",institution:null},{id:"205081",title:"Dr.",name:"Marco",middleName:"Vinícius",surname:"Chaud",fullName:"Marco Chaud",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDGeQAO/Profile_Picture_1622624307737",institutionString:null,institution:{name:"Universidade de Sorocaba",institutionURL:null,country:{name:"Brazil"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/238088",hash:"",query:{},params:{id:"238088"},fullPath:"/profiles/238088",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()