Chapters authored
Experimental Models in Abdominal Aortic Aneurysm
Abdominal aortic aneurysm (AAA) is a potentially fatal disease and survival rate is very low when rupture occurs. Experimental models related with abdominal aortic aneurysm are performed on intact and ruptured aneurysm (RAAA) models. By using AAA models; complex mechanisms of aneurysm formation, aneurysm progression, chance of rupture, preventative and treating methods are researched. Most commonly used methods for creating aneurysm are utilization of transgenic or knockout animals; intra/extraluminal pharmacologic treatments such as elastase, calcium chloride or angiotensin II; hyperlipidemic diet application and surgical interventions such as xenograft, stenosis or graft. Pathogenesis of aneurysm is predominantly examined on rodents whereas studies aimed at development of treatment modalities such as surgical or endovascular interventions are predominantly performed on large animals like rabbit, porcine or dog. Experimental studies modeling aneurysm rupture (RAAA) simulate shock (total hypoperfusion) occurred due to rupture and ischemia/reperfusion (I/R) occurred due to surgical treatment; without creating aneurysm. In this model, end organ or distal organ injuries and methods for reducing these injuries or their hemodynamic effects are investigated by creating shock +I/R.
Part of the book: Abdominal Aortic Aneurysm