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\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
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\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
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\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
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\n\nNote: Edited in October 2021
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by",editors:[{id:"16515",title:"Dr.",name:"Robert",middleName:null,surname:"Gensure",slug:"robert-gensure",fullName:"Robert Gensure"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11698",leadTitle:null,title:"Pigmentation Disorders",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tThis book is intended to be about pigmentation disorders and will aim to include several topics: the first topic is “common hyperpigmentation disorders”. This includes lesions such as melasma, sun-induced lentigo, café-au-lait macules, moles, and malignant melanoma. In the second category “congenital hypopigmented disorders”, diseases such as albinism, piebaldism, hypomelanosis of Ito, and tuberous sclerosis are placed. The third topic is “common and acquired disorders of hypopigmentation”, where diseases such as vitiligo, tinea versicolor, and tinea alba are discussed. The fourth topic is the “treatment of hyper- and hypopigmented disorders”. Types of treatment include sunscreens, hydroquinone, skin peels, retinoids, azelaic acid, laser and IPL therapy, skin surgery, and depigmentation therapy.
\r\n\tThe fifth topic is “complications and drug side effects in the treatment of pigmentation disorders”. These include drug allergies, hyper- and hypopigmentation, persistent skin depigmentation, scars, skin burns, and the potential for skin cancer and skin lymphoma. The last topic is called “coping and support along with skin pigmentation diseases”. Increase the quality of life, psychotherapy, team therapy, and asking for understanding and support from family members.
Mid-face fractures are common in different populations [1, 2]. Facial fractures are detected in almost 5–10% of trauma patients [3]. Motor vehicle accidents seem to be the first cause of mid-face fractures all around the word [4]. The other causes of facial fractures including mid-face trauma indicated in the literature are assaults, falls, sport injuries, and anima attacks [5, 6].
\nThe importance of mid-face is clear in function and esthetics. The mid-face skeleton is important in providing a functional unit for respiratory, olfactory, vision, and digestive systems. The mid-face consists of vertical, horizontal, and sagittal pillars. Understanding the principles of mid-facial repair is the key to optimize the outcome.
\nDiagnosing mid-face fractures is sometimes very difficult in emergency cases. Diagnosis of the types of mid-face fractures is the first and basic step in management of mid-face trauma. The treatment of mid-face fractures is complex due to the physiology and anatomy of mid-facial subunits. Quality of life of the patients is influenced following unsuccessful management of mid-face fractures which lead to permanent functional problems. Esthetic disfiguring trauma changes the whole mid-facial compartments.
\nThis chapter aims to present a comprehensive review of mid-face fractures types’ diagnosis and management.
\nAdvanced trauma life support (ATLS) is the first step that should be applied in emergency cases. Airway obstruction should be evaluated as soon as possible since the mid-face is the beginning of the respiratory pathway. Hemorrhage and secretions may obstruct the oropharynx and nasopharynx. Removal of fractured teeth, clots, and loose dental crowns or dentures is important to open the oral airway. Packing should be used to control acute bleeding. Intubation to secure the airway in instable mid-face fractures is the next step that should be considered in emergency patients [7, 8]. It is important to keep the airway open in mid-face fractures because there is always the potential of airway obstruction due to displacement of bones or severe bleeding in such cases.
\nCervical spine injuries are common in facial fractures. The incidence rate of cervical spine trauma in pediatric facial fracture cases is almost 3.5% [9] whilst this number is much higher in adult trauma patients [10]. According to the possibility of spinal injuries in facial trauma patients stabilizing the cervical spine by a rigid collar is necessary until the spinal injury is ruled out.
\nAfter providing a secure airway, ATLS protocol can continued. When the patient is stable, facial examination to detect the mid-face fractures is executed as follow.
\nLe Fort fractures are classified as three types. Le Fort I injury is defined as separation of maxilla from the mid-face (Figure 1A). Nasal septum, lateral nasal walls, lateral maxillary sinus wall, and pterygoid plates are involved in these kinds of fractures (Figure 2). Le Fort II fracture is also called the pyramidal fracture pattern which is identified by the separation of nasomaxillary complex (Figure 1B). Nasal and lacrimal bones, nasofrontal suture, infraorbital rims, and pterygoid plates are involved in this fracture pattern. Le Fort III also known as craniofacial dissociation is detected by the separation of the whole mid-face from the skull (Figure 1C). This fracture occurs in nasofrontal and zygomaticomaxillary sutures, zygomatic arch, and pterygoid plates.
\nLe Fort I (A), II (B), III (C) fracture patterns on a three-dimensional model.
A, a three-dimensional view of Le Fort I fracture and B, pterygoid plate involvement in Le Fort I fracture (arrow head).
As an initial examination mobility of maxilla is evaluated. The maxillary arch is grasped by thumb and pointing fingers of one hand and the mobility is checked by the other hand on pyriform aperture, nasofrontal suture, and zygomaticofrontal suture. In Le Fort fractures, lateral and medial pterygoid muscles pull the fracture segment posteriorly and inferiorly lead to an anterior open bite deformity. So malocclusion is an important sign in diagnosing the Le Fort fractures. Epistaxis is a common sign in all three patterns of Le Fort fractures. Hypoesthesia of the infraorbital nerve is seen in types I and II of Le Fort fractures. Bilateral periorbital ecchymosis which is called raccoon eyes is a classic sign of Le Fort II and III fractures (Figure 3). The clinician should be aware of the possibility of cerebrospinal fluid (CSF) leak in Le Fort II and III fractures.
\nA classic raccoon eye is a sign of Le Fort II fracture.
The decision to choose whether the open or closed technique in Le Fort fractures is dependent on the mobility of the maxilla and severity of maxillary displacement results in malocclusion. Minor maxillary displacement and malocclusion and low mobility of fractured segment are the indications of closed treatment. Closed technique could be performed by either maxillomandibular fixation (MMF) or skeletal suspension (Figure 4). The method of choice in the treatment of mobile maxilla with severe malocclusion is open reduction and internal fixation (ORIF). In the Le Fort I pattern lateral nasal walls and zygomatic buttresses are used to provide stability by four plates. Displaced Le Fort II fracture is treated by ORIF of bilateral infraorbital rims and zygomatic buttresses simultaneously using a miniplate to fix the nasofrontal suture. Mobile mid-face and esthetic problems following Le Fort III fracture (dish-face deformity) are the main indications of ORIF treatment. The number of fixations is dependent on the extent of comminution and dislocation. Bilateral zygomatic arches and zygomaticofrontal sutures and nasofrontal sutures should be fixed in severely displaced cases.
\nSuspension and closed treatment of comminuted Le Fort fractures.
Hendrickson et al. [11] classified the palatal fracture into six patterns anatomically (Figure 5). Computed tomographies (CTs) in coronal and axial views are helpful in detecting the palatal fractures. Alveolar fracture is classified as type I palatal fracture in which it is categorized into two subcategories of anterior and posterolateral fractures. Anterior type I palatal fracture involves the incisor teeth and involving the posterior teeth it is defined as type 1b palatal fracture. Type II palatal fracture is defined as sagittal fracture which is less common in adults. Type III and IV fractures are the most common palatal fractures in adults [11]. Type III is also called para-sagittal fracture which occurs in the thin part of the palate lateral to the attachment of vomer bone to the maxilla. The anterior limit of the fracture is between canine teeth which extend to the pyriform aperture. Type III fracture pattern extends posteriorly to the tuberosity or track approximate to the midline. Type IV fracture also known as para-alveolar fracture is a variant of the type III pattern. The fracture line in this pattern tracks medial to the alveolar bone of maxilla. The type V pattern is a complex fracture with comminution fragments. The transverse palatal fracture is classified as the type VI pattern which is the least common palatal fracture type.
\nClassification of palatal fractures.
Mobility of alveolar segments should be checked for the entire maxillary arch. Displacement of fractured segments results in malocclusion which is an important sign to the clinician in diagnosing the palatal fracture. Ecchymosis of the palate may also indicate the line of fracture.
\nWhen the occlusion is good enough and the fractured segment is either minimally displaced or not displaced at all the surgeon may decide to follow the patient and choose no intervention. MMF is the treatment of choice in minimally displaced palatal fractures unless there is a contraindication for MMF. Gunning and palatal splints are other amenable methods for closed treatment of palatal fracture (Figure 6). ORIF of palatal fracture is indicated in severely mobile and displaced patterns to prevent splaying of the fragments.
\n(A) Gunning for closed treatment of simultaneous mandibular and palatal fractures in an edentulous patient and (B) Maxillomandibular fixation for closed treatment of the patient.
According to the involved orbital walls there are five fracture patterns. The most common fracture of the orbit is the orbital floor fracture mostly detected as a blow-out fracture [6] (Figure 7). Orbital roof fracture is the most common fracture in pediatric population [12]. Other less common orbital fractures involve medial or lateral wall. Combined orbital fracture especially involving all four orbital walls are the least common orbital fracture [6] patterns whilst the leading functional and esthetic problems of this pattern are much more serious than former fracture types.
\nCoronal CT view indicating orbital floor (blow out) fracture.
Entrapment of extraocular muscles should be assessed when there is suspected orbital wall fracture (Figure 8). Forced duction test is helpful in distancing between muscle entrapment and neurologic disturbance although this test is sometimes falsely negative due to post-injury edema. Diplopia is a common sign of orbital fracture, especially medial fracture pattern due to rectus muscle entrapment [13]. Infraorbital nerve hypoesthesia is a symptom of orbital fracture especially when the infraorbital rim is involved [14]. Subconjunctival hemorrhage and periorbital ecchymosis are useful signs of an underlying orbital fracture [15] (Figure 9). Enophthalmus is an important sign of orbital fracture and also a significant indication of orbital reconstruction [16]. Enophthalmus usually occurs as a result of increased orbital volume or loss of orbital content especially orbital fat.
\nThe patient is not able to look upward concurrently by both eyes due to left orbital floor fracture lead to inferior rectus muscle entrapment.
Periorbital ecchymosis and subconjuctival hemorrhage following orbital fracture.
Orbital fracture cases are non- or minimally displaced should just observe. No intervention is needed when Orbital fractures do not result in any ocular problems including diplopia or enophthalmus. Orbital fracture treatment is a controversial issue among maxillofacial and oculoplastic surgeons. Fracture size, timing of the reconstruction, and biomaterials for reconstructions are all important issues which should be considered in orbital fracture repair. The debate still is present in deciding on whether to treat an orbital fracture or not. The investigations are insufficient with high heterogeneity in this field. As a general rule it is almost acceptable that defects more than 50% of the orbital wall or 2 cm length should be treated [17]. Enophthalmus and positive-forced duction tests are two indications for management of orbital wall fractures.
\nTiming of orbital reconstruction is categorized into three groups of immediate categories: within 24 h, early (between first and day 14), and delayed (after 2 weeks) [18]. When the reason of diplopia is muscle entrapment immediate reconstruction of the orbit is advocated by the investigators. Blow-out fracture in young patients is the other indication for immediate repair. Early orbital reconstruction is advocated by some surgeons in cases of early enophthalmus and symptomatic diplopia with positive forced duction test. Early reconstruction should also be considered in cases with large orbital wall defects (more than 50% defects). Symptomatic diplopia with negative force duction test and late-onset enophthalmus are indications for delayed orbital reconstructions [18].
\nDecision-making on the ideal material for orbital reconstruction is based on the surgeon’s experience, cost, defect size, and medical history (Figure 10) [19]. The available material and their pros and cons are categorized in Table 1.
\nTitanium meshwork plate is used to reconstruct the orbital floor defect.
Materials | \nExamples | \nAdvantages | \nDisadvantages | \nIndications | \n
---|---|---|---|---|
Autogenous bone grafts | \nIliac bone graft, caldaria grafts | \nBiocompatibility, cost effective, variability in thickness, radio opacity | \nDonor site morbidity, difficult to shape, high resorption rate | \nLarge defects, immature orbits, secondary defect reconstruction | \n
Resorbable materials | \npoly-l-lactic acid (PLLA), | \nReplacement with bone formation | \nHigh cost, radiolucency, low stability | \nSmall defects | \n
Non-resorbable materials | \nTitanium mesh, Porous polyethylene sheets | \nHigh stability, easy fixation, availability, no donor site defect | \nHigh cost, increased infection rate | \nMedium size defects with medium complexity | \n
Materials available for orbital reconstruction.
According to Markowitz’s classification naso-orbital-ethmoid (NOE) fracture is defined as three patterns [20] (Figure 11). Type I NOE fracture is defined as single-segment central fragment. This pattern could be in a uni- or bilateral form. The medial tendon is attached to the fractures segment in this pattern. Type II NOE fracture consists of comminuted central fragments external to the medial canthal tendon insertion. In type III fracture the fracture line extends into the medial canthal insertion segment. The medial canthal tendon either remains attached to the central segment or does not.
\nNaso-orbital-ethmoid fracture types. A, type I Naso-orbital-ethmoid fracture. B, type II naso-orbital-ethmoid fracture. C, type III naso-orbital-ethmoid fracture.
Epistaxis is a common sign of NOE fracture. Involving the NOE complex in trauma patients results in splayed nasal complex and widened the nasal bridge. In the case of medial canthal tendon detachment or disruption of traumatic telecanthus and medial canthus rounding occurs (Figure 12). The intercanthal distance is usually half of the interpupillary distance (average of 28–35 mm in white adults). So when this measure is more than 40 mm or half of the interpupillary distance, the traumatic telecanthus is defined [21]. Bimanual test is a useful method in detecting the instability of NOE fracture [22].
\nSigns in a patient with naso-orbital-ethmoid fracture. Rounding of the left medial canthus (arrow) and traumatic telecanthus is obvious in this patient.
Stabilization of the fractures segment is the only intervention advocated in NOE type I fracture (Figure 13A). Stabilizing the central fragment in which the medial canthal tendon is inserted is the treatment of choice in type II fracture (Figure 13B). Transnasal wiring simultaneously with orbital medial wall reconstruction is considered in type III pattern.
\nA, fixation of the type I naso-orbital-ethmoid fracture. B, reconstruction of left type II naso-orbital-ethmoid fracture.
Intraoral approach and vestibular incision is the most common technique used in treatment of Le Fort fractures (Figure 14). Circum-vestibular incision mesial to the second premolar is used to reach the nasal lateral walls and zygomatic buttresses. As mentioned earlier these buttresses are stable enough to maintain the maxilla at the right position following rigid fixation. Cinch suture and V-Y plasty is necessary when the incision involves the nasalis muscles.
\nIntraoral approach to expose the Le Fort I fracture line.
After decision-making of rigid fixation of the Le Fort III fracture, extraoral approaches to the zygomaticofrontal and nasofrontal sutures are applied (Figure 15). Bicoronal flap is the common approach to achieve all three sutures by one sing incision. Also this is a good approach in repairing the NOE fracture. The incision is made several centimeters behind the hair line between the upper origins of the temporal muscles from one superior temporal line to the other. Dissection of the flap is performed in the subgaleal plane up to 2 cm above the superior orbital rims. The periosteum is incised at this level and subperiosteal dissection is continued to expose the zygomaticofrontal and nasofrontal sutures. Using a suction drain is optional during closure.
\nCoronal approach for management of Le Fort III fracture (courtesy of Dr. Fereydoun Pourdanesh).
When there is no displacement of nasofrontal suture, fixation of zygomaticofrontal sutures is applicable by lateral brow approach. The incision is made almost 2 cm parallel to the hair follicles of the lateral eyebrow (Figure 16). The advantages of this technique are least noticeable scar and no adjacent anatomical structure.
\nLateral brow approach.
Glabellar and ethmoidal (known as Lynch approach) approaches are used in solitary NOE fracture. The latter technique is not recommended by AOCMF due to visible scar band (web) [23]. Glabellar incision is made in old patients in the glabellar furrows through the skin, subcutaneous layer, and the periosteum.
\nFour kinds of periorbital approaches are represented in the literature for reconstruction of orbital fractures and Le Fort II fracture. The incisions on the lower lid are classified into three types based on the distance from the gray line (Figure 17). The periorbital approach is called subciliary incision when this distance is about 2–3 mm. When this distance is almost 3–4 mm to the gray line the incision is known as mid-lower lid or subtarsal approach. The dissection of these two techniques is in three fashions. The best dissection technique is to start a few millimeters subcutaneously followed by orbicularis oculi muscle dissection. Skin only or pre-orbicularis oculi muscle incision is not advocated by authors due to high possibility of ectropion rate. The third incision is called skin-muscle flap which involves both skin and orbicularis oculi muscle.
\nPeriorbital incisions. Subciliary (A), subtarsal (B), and infraorbital (C) approaches are shown in this picture.
Another popular periorbital approach because of its invisible scar is the transconjunctival technique (Figure 18). The incision is made parallel to the gray line through the conjunctive. This approach is divided into preseptal and retroseptal techniques based on the dissection plane. Lateral canthotomy and inferior cantholysis are used in some cases when the surgeon needs more access to the orbit.
\nTransconjunctival approach is used to expose the orbital floor fracture.
The mid-face is esthetically and functionally very important which makes repairing the deformities of this facial part very difficult. Diagnosing the exact injuries on the facial bones is the key step of deciding the treatment plan. The surgeon should have enough knowledge of facial anatomy and physiology to be able to reconstruct the fractured segments. Deformity following facial trauma is hard to repair on the second surgery. So the importance of managing almost all problems of mid-face fractures in the first surgery is pretty clear to all traumatologists.
\nThe authors declare that they have no conflict of interest. The photos not referenced in the text belong to the author.
Coastal zones are now experiencing increased natural and human disruptions, such as sea-level rise, coastal erosion, and resource overexploitation, to name a few. Coastal erosion affects almost 80% of the world’s beaches, with rates ranging from 1.0 cm year−1 to 30 m year−1, posing a major threat to several coastal regions [1]. According to [2], increased knowledge of many driving forces is affecting the health of global coastal ecosystems has expedited efforts to evaluate, monitor, and reduce coastal stressors to understand the spatial distribution of erosion risks, predict their growth tendency, and support mechanism research on erosion and its solutions.
Shoreline extraction and change detection rates at different times are critical for coastal zone monitoring. The coastline, defined by [3] as the position of the land-water interface at a single point in time, is a highly dynamic characteristic that serves as a predictor of coastal erosion and accretion. Shoreline changes occur on a variety of time scales, ranging from geological to short-term catastrophic events. Waves, winds, tides, sea-level rise, frequent storms, geomorphic processes of erosion and accretion, and human activities are all factors that affect these changes [4].
Several international studies looked at quantitative and qualitative analysis of shoreline spatiotemporal fluctuations [5, 6, 7, 8, 9, 10, 11, 12, 13].
Alternatively, efforts were made to estimate the potential position of the shoreline to reduce the impact of the upcoming erosion activity. Moreover, for future predictions of shoreline spatial change, extensive and reliable information regarding historical and present coastline position is required. In a GIS framework, shoreline prediction models are simple to implement. With the help of historical data, several statistical models for example the Average of Rates (AOR), Least Median of Squares (LMS), Linear Regression Rate (LRR), End Point Rate (EPR) model, and Jackknife model (JK) were used to evaluate shoreline prediction [12, 14, 15, 16, 17, 18, 19].
Few encouraging investigations have been conducted along Egypt’s North Sinai shore [20] used an aerial picture taken in 1955 and a topographic map analyzed in 1992 to describe the shoreline alteration along Sinai’s northern coast. Despite this, the magnitude of shoreline variations was not quantified in their analysis due to the inability of the analyzed maps’ surveying methodologies to calculate it. Moreover [21] used a hydrographic survey to investigate the impact of the El Arish power station (located west of the El Arish valley coast) on the surrounding area on Sinai’s Mediterranean coast. The authors discovered a 5.5 m/year coastline retreat east of the El Arish power plant breakwater [22] used topographic maps from 1973 with satellite pictures from 1984 and 1996 to tutor the coastal changes over the western half of the North Sinai coast (i.e., from El Tinah Bay to El Bardawil Lake). They also calculated how the area of El Bardawil Lake changed throughout time. They discovered that the extent of El Bardawil Lake changed dramatically from 1973 to 1984, losing an average of 128 km2, then slowing to a loss of 5 km2 from 1984 to 1996. El Banna et al. (2009) used the same method to track changes in the shoreline along the North Sinai coast for 15 years (from El Bardawil Lake to Rafah) by studying TM and ETM true color Landsat pictures from 1986 to 2001. The accretion and erosion rates were calculated to be +0.076 km2 year−1 and 0.123 km2 year−1, respectively.
To sum up, the extensive literature survey undertaken in the North Sinai coast area demonstrated that the current published data related to the area needs to be improved and renovated. Furthermore, it cannot determine coastline change rates with high-precision approaches. The current study uses GIS and DSAS geospatial approaches to examine shoreline changes along the North Sinai coastline from 1989 to 2016. Furthermore, the current research aims to: (1) apply three different semi-automated shoreline extraction methods, including Histogram threshold of band ratio, Histogram threshold of band 5, and Tasseled Cap Transformation (TCT); (2) plot and measure shoreline accretion/erosion rates using several statistical methods functionalized in DSAS, including NSM, LRR, EPR, and LMS; and (3) develop a decision-support algorithm that can vigorously support in elaborating shoreline accretion/erosion rates; (4) using the EPR model, outline a futuristic decision plotting based on the North Sinai shoreline forecast in the years 2025, 2035, and 2050.
Sinai’s coastal area is considered an essential part of Egypt’s Mediterranean Coast [22]. It is a geographical connecting point between Asia and Africa, with the Gulf of Suez and the Suez Canal on the west, the Gulf of Aqaba and the Egyptian-Israeli border on the east, and the Mediterranean Sea on the north (Figure 1). The latitudes and longitudes are (28°–31°N) and (32° 30/–34° 30/ E) respectively. The northern Sinai coast stretches for about 220 km along the Mediterranean Sea, extending from Port Said in the west to Rafah in the east, from the Egyptian border [23]. The current study area is split into three subzones based on the vulnerability of coastal areas as well as the availability of data from the field and remotely sensed data. Zone I contain El Tinah Plain Bay, which stretches 38.5 km from Port Said in the west to El Bardawil Lake in the east, (Figure 1a). Zone I is characterized by some features such as Lagoons, vegetation cover, and fish ponds. Zone II includes El Bardawil Lake (Figure 1b). This lake covers approximately 60% of Sinai’s northern coast. It has a total area of over 700 km2 and is approximately 72.5 km long, 22 km wide-ranging, and 2 m deep. The Mediterranean Sea is isolated from the Lake by shallow sand barriers that range in width from 300 to 1000 m, and are overtopped by storm waves in the winter. It has three inlets joining it to the Mediterranean Sea, two of which are manmade (no. 1 and 2) and one of which is natural (El Zaranek inlet), [24]. Zone III includes the El Arish Valley shore, which almost forms a 37 km west-to-east intersection between the El Arish power plant and Rafah, (Figure 1c).
False-color composite images of the study area and shoreline digitization in different periods from (1989–2016) for the three zones (a, b, c) respectively, after [
The intensity and direction of wave action along Egypt’s Mediterranean coast are inextricably linked to significant pressure systems over the Mediterranean and North Atlantic [25]. Wave heights reach 1.16 m and average 0.4 m during the spring and summer, with the prevailing wave direction being NW. Prevailing wave direction is come mainly from N, NNW, and NW in Winter. The maximum wave height is 4.25 m, with an average wave height of 0.51 m and a period of 6.5 sec.
Wave data was analyzed previously by [26, 27, 28] along Egypt’s Mediterranean coast show that waves from the northwest predominate (81%), with small components from the northeast (14%) and southwest (5%). The prevailing wave direction is the main key of the eastward-flowing alongshore current. Reversed alongshore currents are generated by waves incoming from the N, NNE, and NE (Figure 2). The main alongshore current path (62–65%) on the North Sinai coast is from west to east, stimulated by waves from the NNW and NW, according to preceding measured data. However, west trending alongshore currents (24–29%) result from the remaining wave components from the N, NNE, and NE, particularly during March and April due to easterly winds. Furthermore, with a range of 31 cm, the tide along Sinai’s Mediterranean coast is micro-tidal and semi-diurnal. The average high water level is 20 cm, and the average low water level is −11 cm [30].
Wave rose for study area, and wave induced currents’ directions (modified from El Banna et al., 2009), after [
This study used multi-temporal satellite data from Landsat TM, ETM, and OLI/TIRS that cover our coast from 1989 to 2016. Even so, thanks to the shortage of cloud-free imagery during the selected period, satellite images could not be obtained at regular intervals. The polynomial geo-rectification method is used to ortho-rectify the selected satellite images, as it is afterward used to track changes in the shoreline along the Sinai Peninsula’s northern coast Satellite images’ data are described in detail in Table 1. Data acquired for North Sinai coastline surveying from El Tinah bay to El Arish valley was supplied by the Egyptian Institute of Oceanography and Fisheries in 2010.
Satellite data | Path/Row | Year of acquisition | Resolution (pixel size) | Zone |
---|---|---|---|---|
Landsat 4 - TM | 176/38 | 1989 | 30 m | I |
Landsat 5 - TM | 175/38 | 1989 | 30 m | II and III |
Landsat 5 - TM | 176/38 | 1998 | 30 m | I |
Landsat 5 - TM | 175/38 | 1998 | 30 m | II and III |
Landsat 7 - ETM | 176/38 | 2003 | 30 m | I |
Landsat 5 - TM | 175/38 | 2003 | 30 m | II and III |
Landsat 7 - ETM | 176/38 | 2010 | 30 m | I |
Landsat 7 - ETM | 175/38 | 2010 | 30 m | II and III |
Landsat 8 - OLI/TIRS | 176/38 | 2016 | 15 m | I |
Landsat 8 - OLI/TIRS | 175/38 | 2016 | 15 m | II and III |
Related abbreviations: | ||||
TM | : Thematic Mapper; | |||
ETM | : Enhanced Thematic Mapper; | |||
OLI | : Operational Land Imager; | |||
TIRS | : Thermal Infrared Sensor. |
Details of satellite dataset for North Sinai (acquired via https://earthexplorer.usgs.gov/).
Image processing carried out in this study were strip filling, georeferencing, and radiometric correction. Firstly, gap filling was applied to image 2010 for all its bands using modeling done by [31] in Arc GIS 10.2.2 using the python algorithm, see Figure 3.
Landsat image for zone I in 2010; (a) before gap filling; (b) after gap filling.
Ground Control Points (GPCs) are used to implement the geometric correction process (i.e. more than 40 GCPs are identified on the images), [10, 32]. The geometric correction is accomplished utilizing ENVI 5.3 software to reduce distortions caused by scale variation, angle, and lens distortion.
The image is projected to actual coordinate Universal Transverse Mercator (UTM), WGS-84 datum. After georeferencing, (RMSE) was found to be less than 0.5 pixels, indicating that the images were geometrically well-matched. After that, a radiometric correction is applied using the ENVI software’s radiometric, which combines the sun and view angle effects, as well as sensor calibration and atmospheric correction. Eventually, all georeferenced images are processed in ArcGIS to get the coastline digitized.
Shorelines are the high water line as surveyed by GPS units in kinematic mode [33]. Meanwhile, automatic coastline demarcation from low resolution satellite images is a complicated job due to the unclear boundary between water and land in saturated zone [34]. Three semi-automatic delineation approaches are first tried for Landsat images ETM 2010 in this study to identify the best digitization methodology that gives the least error with the related field data in 2010 (Figure 4).
Methodology framework to extract shoreline.
Since water absorbs the majority of radiation in the near-infrared and mid-infrared regions of the spectrum, its reflectance in these wavelengths is nearly zero; nevertheless, the reflectance is higher in these areas for land cover than water bodies. As a result, the coastline can be derived from a single band image. As a consequence, getting the binary image is becoming simple by estimating the histogram threshold for one of the infrared bands (i.e. Band 5) of the TM or ETM imagery [35]. Another method is to use the histogram threshold of band ratio technique, which produces a binary image by combining the two conditions of Band (2)/Band (4)
Moreover, the Tasseled Cap Transformation technique (TCT) is also used to extract shorelines. The coefficients for TCT of Landsat data are determined from [37]. TCT reconstitutes the spectral information of the six ETM bands into three primary perspective elements using coefficients deduced from sampling known land cover spectral features. The moistness component is used to distinguish land from water among the three main view elements (brightness, greenness, and wetness). In this wetness index band, the land-water configuration is clearly visible, and a binary image could be easily acquired. Finally, in 2010, each technique’s raster binary image is transformed into a vector image, which can then be used to extract the coastline border.
To identify the best technique, a comparison is made in Arc GIS 10.2.2 for the three regions between the derived shorelines (e.g., by TCT) and the observed shorelines in 2010 (Figure 5). This comparison is assessed using DSAS tools, which developed by the United States Geological Survey (USGS). The original purpose of this extension is to compute change rate in coastline’ positions. Using DSAS is summarized in the following steps: After extraction of shoreline, the baseline is created; creating transects; calculating the distances between coastline and baseline for transects; finally, the shoreline change rate is calculated [38]. Accordingly, the deviation between the derived and observed shoreline is computed using 1800 perpendicular to the baseline transects. These transects are accurately cast at intervals of 20 m (Figure 5a–c).
Comparison of digitized shorelines based on field data from 2010 and the corresponding Landsat imagery (e.g., using TCT) for (a) Zone (I); (b) Zone (II); (c) Zone (III).
Figure 6 depicts a validation process between data from a field investigation and extracted shoreline from satellite image obtained in 2010. It is based on the coupling of DSAS software and Arc GIS 10.2.2. The residuals between the measured and computerized shorelines in 2010 at each transect line from 1 to 1800 were estimated using both the histogram threshold of band 5, histogram threshold of band ratio, and TCT, as shown in Figure 6a–c. It is noticed that data are reasonably correlated (Figure 6a1, b1, and c1).
Validation process between the shoreline monitored in the field and the shoreline detected by imagery 2010 for the different zones based on NRMSE of ; (a,a1) histogram threshold of the band (5); (b,b1) histogram threshold of band ratio; (c,c1) TCT.
The normalized root means square error (NRMSE) is considered to find the best method that precisely extract the coastline. TCT technique is proved to be better in shoreline delimitation using low resolution satellite imagery (medium resolution). It achieved the least NRMSE for all zones, Figure 6a1, b1, and c1. As a result, the TCT technique was used to demarcate shorelines in 1989, 1998, 2003, and 2016 (see sectors a1, b1, b2, c1, and c2 in Figure 1a–c).
Changes in the shoreline locations are calculated using different four analysis methods (i.e., EPR, LRR, LMS, and NSM). The End Point Rate (EPR) is easily determined by dividing the length (in m.) between two coastlines by number of the years (Eq. (1) and Figure 7). This method is widely used by different coastal researchers and is widely used in shoreline movement rate calculations [39, 40, 41, 42].
Detecting changes of zone I; (a, b) Satellite images (TM) and OLI/TIRS of band (5) for the year1989 and 2016; (c, d) TCT’s equivalent binary images from 1989 and 2016; (e) The Change detection image for the period 1989 to 2016; (f) Vector map showing the erosion/accretion pattern showed in vector map for the period 1989 to 2016.
where:
L1 and L2 are the distances between the baseline (benchmark) and the shoreline, while t1 and t2 are the dates of the two shoreline locations.
Linear Rate Regression (LRR) is the second method for calculating change rates. For a specific transect, this method entails fitting a least-squares regression line to multiple shoreline location points, (Figure 8). R-squared (Eq. (2)), R2 > 0.87 has been held as the threshold of certainty in our research, considering a confidence interval (LCI) of 95%. R2 at each transect line are calculated as follows:
Explanatory example of NSM, EPR, LRR, and LMS computation; (a) Map of multi-temporal shoreline locations west and east El Bardawil inlet (1); (b) transect line’ details (x) and coastline intersection; (c) Time series of shoreline distances from the baseline along the transect line (x).
where:
L: observed distance between the reference line(baseline) for a coastline’ data point;
Lp: forecast value based on the best-fit linear regression equation;
L−: Average of the observed shoreline data points; and.
N: number of dates.
The sample data are used to calculate an average offset in the linear regression method, and the formula for the line is deduced by reducing this value so that the source points are as near to the regression line as possible. In the least median of squares method (LMS), instead of using the average, the median value of the squared residuals is used to identify the optimal equation for the line (Figure 8).
The net spacing (in meters) between the past and present shoreline locations for each transect is recognized as the Net Shoreline Movement (NSM) (i.e., 1989 and 2016). It represents a distance rather than a rate (Figure 8b).
EPR, LRR, LMS, and NSM have negative values, implying landward decline of the shoreline, whereas positive values indicate landward advancement. The erosion/accretion rates measured along the North Sinai coast are divided into seven categories (Table 2) [43].
Category | shoreline change’ rate (m/year) | classification of shoreline |
---|---|---|
1 | > -2 | Very high erosion |
2 | > -1 and < -2 | High erosion |
3 | > 0 and < -1 | Moderate erosion |
4 | 0 | Stable |
5 | > 0 and < +1 | Moderate accretion |
6 | > +1 and < +2 | High accretion |
7 | > +2 | Very high accretion |
The classification of Shoreline according to EPR, LRR, and LMS.
A long-term process of two-dimensional shoreline change detection has been extensively investigated along the coastal line of different three zones over a 27-year period (1989–2016). This procedure is conducted through different steps. Firstly, binary images from 1989 and 2016 are derived for each zone using TCT techniques to separate land and water. This step masks the land cover with all of its categories. Second, the binary images are converted from raster to vector (feature class) using ArcGIS10.2.2 software, with two main polygon attributes: water and land. Finally, the two polygon layers are superimposed to assess shoreline erosion/accretion trend from 1989 to 2016, (Figure 7f).
As a result, Figure 7a and b show satellite TM and OLI/TIRS images of the band (5) for zone I in 1989 and 2016, respectively, while Figure 7c and d show their classified binary images The post-classification change detection image (Figure 7e) on the other hand, shows severe erosion in El Tinah Bay’s western part. This erosion is the result of the combined effects of the coast’s stormy climate and the restriction of sediment movement from the Nile Delta as a result of the construction of both the jetties at Suez Canal entrance and seawalls at eastern canal. Besides that, a portion of the incident wave’s energy is shifted into the adjacent beach due to the construction of this seawall. Consequently, the shifted energy, soil disconnection has occurred in the western part of El Tinah Bay. Based on the hydrodynamic processes on the North Sinai coast, alongshore currents induced sediments to move from west to east, resulting a highly sensitive eroded area (Figure 7f, f1).
In 2013, a natural opening nearly in the middle of El Mallaha Lagoon was formed as a result of this erosion. Furthermore, as a result of hindering the sediment path by inlet (2) jetties and groins at east of the inlet, part of the transported sediments has settled nearly in the middle of El Tinah Bay shoreline. In 2015, the artificial inlet (2) was completely blocked due to sediment restrictions.
The eastern part of the Bay, on the other hand, appears to be relatively stable. This part’s shoreline is almost straight, with no major merged parts to erode or major embayments to receive sediments, hence, the shore zone is nearly stable; Only a few small pockets of accumulation have been noticed. To quantify the dynamical changes in the zone I coastline from 1989 to 2016, an asymmetrical difference vector map is created from binary images in ArcGIS10.2.2 and is then classified into two categories: erosion and accretion pattern, (Figure 7f). The change detection clearly shows a cumulative accretion of +3.442 km2 and a rate of +0.127 km2/year, while the cumulative erosion is −5.409 km2 and a rate of −0.2 km2/year over a period of 27 years (Table 3).
Study zone | Research | Date | Data source | The used technique | Area (km2) | Rate (km2/year) | ||||
---|---|---|---|---|---|---|---|---|---|---|
Loss | Gain | Net | Loss | Gain | Net | |||||
I | (Azab & Noor 2003) | 1973-1996 | Topographic maps | Manually by FCC | -3.22 | 2.42 | -0.81 | -0.14 | 0.105 | -0.035 |
Present study | 1989-2016 | Satellite imagery | TCT | -5.41 | 3.44 | -1.97 | -0.2 | 0.127 | -0.073 | |
II | (Azab & Noor 2003) | 1973-1996 | Topographic maps | Manually by FCC | -4.12 | 2.19 | -1.93 | -0.179 | 0.095 | -0.084 |
(El Banna et al. 2009) | 1986-2001 | Satellite imagery | Histogram threshold | -3.03 | 1.52 | -1.52 | -0.202 | 0.101 | -0.101 | |
Present study | 1989-2016 | Satellite imagery | TCT | -6.95 | 4.37 | -2.57 | -0.257 | 0.162 | -0.095 | |
III | (El Banna et al. 2009) | 1986-2001 | Satellite imagery | Histogram threshold | -0.63 | 0.77 | 0.138 | -0.042 | 0.051 | 0.0092 |
Present study | 1989-2016 | Satellite imagery | TCT | -1.61 | 1.947 | 0.339 | -0.059 | 0.072 | 0.0126 | |
Overall | Present study | 1989-2016 | Satellite imagery | TCT | -24.9 | 16.6 | -8.31 | -0.925 | 0.61 | -0.308 |
Calculated area of erosion(-ve), accretion(+ve), and net balance surfaces along the North Sinai coast.
The defined trend of the two-dimensional shoreline change rate (km2/year) along the coastline, extracted using TCT technique is noticed to be rather coherent with other earlier studies when compared to the other two remote sensing techniques. This is evident when the current results have been compared with the previous results in researches of [22, 23] as shown in
Mean change rates (km2/year) along the North Sinai shoreline.
The digitized shorelines have been used in the ArcGIS extension Digital Shoreline Analysis System (DSAS) to calculate the rate of shoreline change in vector format over a specific period of time [44]. DSAS is a statistical software applied in coastal research to compute rate of change from historical GIS-based shoreline positions [45].
In this study, DSAS is utilized to calculate shoreline change rate from different historical shoreline locations along the North Sinai coast in 1989, 1998, 2003, 2010, and 2016. The method for determining shoreline change rates begins with the creation of a personal geodatabase for the extracted shoreline positions in ArcCatalog 10.2.2. Each shoreline has attributes that include date, length, ID, shape, and uncertainty. Each image’s acquisition date is entered in the date column, whereas the length, ID, and shape are easily obtained. Uncertainties are also measured (Table 2) and recorded in the uncertainty column as integers. The five shoreline positions are then appended to one shapefile. Thereafter, speculative baseline is formed from the shoreline. Three different methods are available in DSAS to delineate baseline: (1) constructing a baseline along the shoreline at a particular distance; (2) utilizing a previously established baseline; (3) buffering method. The last method is the most consistent and accurate technique for baseline demarcation because it uses the same sinuosity shape as the nearby shoreline, so it was selected for the current study [12].
The baseline is then created at a buffering distance of 1000 meters offshore from the nearest shoreline.
These attributes provide DSAS with information about the sequence of transects as well as the baseline’s position in relation to the shoreline (onshore or offshore). Transects have been set orthogonally from the benchmark (baseline) along the coastline of various years in 100 m intervals for the three different zones. Finally, the shoreline change rates are statistically computed using the various techniques (i.e., EPR, LRR, LMS, and NSM). As shown in (Figure 10a–c), a qualitative analysis is performed to determine the related erosion/accretion transects using the NSM model. The field that connects the table of NSM statistical results to the transect feature class is the field that they have in common. Where the values in the transect-ID field of the NSM results table are equal to the object identifier field (Object ID) in the transect feature class. After completing the joining process, the symbology of the transect feature class can be adjusted to classify transects into two categories: erosion (green transects) and accretion (orange transects), (Figure 10). Most beaches in zones I, II, and III are susceptible to accretion and retreat (1989–2016), according to the delineation of erosion and accretion transects.
Qualitative analysis of erosion/accretion transects using NSM, conducted in DSAS, in the years of 1989, 1998, 2003, 2010, and 2016 for (a) zone (I); (b) zone (II); (c) zone (III).
Furthermore, the results reveal that, 49.61% (191 transects), 73.52% (533 transects), and 72.24% (255 transects) of the coastline corresponding to 19.1, 53.3, and 25.65 km are experiencing erosion for zone I, II, and III respectively. On ht. eother hand, 50.39%, 26.48%, and 27.76% of the coastline with lengths of 19.4, 19.2, and 9.85 km are suffering accretion (
The rates of shoreline change are computed annually for each zone during the period from 1989 to 2016 using the statistical outcomes of EPR, LRR, and LMS (Figure 11). The findings of this study are summarized in
Shoreline change rates by EPR, LRR, and LMS (m/year) for Zones, (a) I; (b) II; and (c) III during the period from 1989 to 2016. Shoreline change rates by EPR, LRR, and LMS (m/year) for Zones, (a) I; (b) II; and (c) III during the period from 1989 to 2016.
Comparison of shoreline change rates (m/year) calculated by, (a) EPR vs LRR; (b) EPR vs LMS; (c) LRR vs LMS for the overall North Sinai coast.
Geospatial techniques and DSAS models were utilized to assess the shoreline morphodynamic changes along the North Sinai shoreline between 1989 and 2016 via multi-temporal satellite images. The semi-automatic shoreline extraction method (Tasseled Cap Transformation technique, TCT) was accustomed to digitalize the shoreline positions in 1989, 1998, 2003, and 2016. Extreme variance in the spatial scale characterizes the study area where the highest obtained coastal erosion/accretion kinematics for El Arish valley coast, El Bardawil Lake, and El Tinah Bay are −1.61/+1.95 km2, −6.95/+4.37 km2, and − 5.41/+3.44 km2, respectively.
Moreover, the construction of eastern jetty of the Suez Canal extremely lowered sediments inputs to El Tinah Bay, which highlighted the erosion of the western segment by wave hydrodynamics and the eastwards alongshore currents. Contrary, the eastern part of El Tinah Bay has demonstrated a nearly constant shoreline throughout the study period. Instantaneously, protection jetties of El Bardawil inlet 1, El Bardawil inlet 2, and El Arish Harbor have intermittent long-shore sand movement resulting in a continuous erosion at the downdrift side and an accretion at their updrift side. The institution of El Arish power plant has substantially decreased the sedimentary routine and created destructive impacts on coastal dynamics in the west of El Arish harbor.
In the meantime, the forthcoming speculation of the North Sinai coastline variations is predicted using the End Point Rate (EPR) model for the near future of years 2025, 2035, and 2050 after model validation based on 2010 data. A well-matching between the historical and futuristic trends of shoreline is obtained which means the calculation is almost succeeding the same accretion and erosion patterns. Study results in this chapter prove that medium-resolution satellite images, geospatial features of the GIS, and digital shoreline analysis system (DSAS) successfully assessed the coastal morphodynamic changes and shoreline detection of the North Sinai coast and could be used for other coastal areas based on the data quality and availability. Additionally, the results of this study deliver a high-reliable tool to the decision-makers and the coastal managers to support their decision when developing sustainable coastal management plans for North Sinai coast.
The author would like to thank the editor and the reviewers for their constructive comments for enhancing the chapter quality.
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Over the past few decades, no major new types of antibiotics have been produced and almost all known antibiotics are increasingly losing their activity against pathogenic microorganisms. The levels of multi-drug resistant bacteria have also increased. It is known that worldwide, more than 60% of all antibiotics that are produced find their use in animal production for both therapeutic and non-therapeutic purposes. The use of antimicrobial agents in animal husbandry has been linked to the development and spread of resistant bacteria. Poultry products are among the highest consumed products worldwide but a lot of essential antibiotics are employed during poultry production in several countries; threatening the safety of such products (through antimicrobial residues) and the increased possibility of development and spread of microbial resistance in poultry settings. 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This chapter thus briefly discusses different biological methods, specially biofilm technologies, the development of biofilms on different filter media, factors affecting their development as well as their structure and function. It also tackles various conventional and modern molecular techniques for detailed exploration of the composition, diversity and dynamics of biofilms. These data are crucial to improve the performance, robustness and stability of biofilm-based wastewater treatment technologies.",book:{id:"5197",slug:"microbial-biofilms-importance-and-applications",title:"Microbial Biofilms",fullTitle:"Microbial Biofilms - Importance and Applications"},signatures:"Shama Sehar and Iffat Naz",authors:[{id:"180364",title:"Dr.",name:"Iffat",middleName:null,surname:"Naz",slug:"iffat-naz",fullName:"Iffat Naz"},{id:"183345",title:"Dr.",name:"Shama",middleName:null,surname:"Sehar",slug:"shama-sehar",fullName:"Shama Sehar"}]},{id:"49246",doi:"10.5772/61300",title:"Chitosan as a Biomaterial — Structure, Properties, and Electrospun Nanofibers",slug:"chitosan-as-a-biomaterial-structure-properties-and-electrospun-nanofibers",totalDownloads:4727,totalCrossrefCites:27,totalDimensionsCites:63,abstract:"Chitosan is a polysaccharide derived from chitin; chitin is the second most abundant polysaccharide in the world, after cellulose. Chitosan is biocompatible, biodegradable and non-toxic, so that it can be usedin medicalapplications such as antimicrobial and wound healing biomaterials. It also used as chelating agent due to its ability to bind with cholesterol, fats, proteins and metal ions.",book:{id:"4648",slug:"concepts-compounds-and-the-alternatives-of-antibacterials",title:"Concepts, Compounds and the Alternatives of Antibacterials",fullTitle:"Concepts, Compounds and the Alternatives of Antibacterials"},signatures:"H. M. Ibrahim and E.M.R. 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Aggregation continues with the maturation of biofilm. Dispersion is started by certain conditions such as phenol-soluble modulins (PSMs). By this way, sessile bacteria turn back into planktonic form. Bacteria embedded in biofilm (sessile form) are more resistant to antimicrobials than planktonic bacteria. So it is hard to treat biofilm-embedded bacteria than planktonic forms. For this reason, it is important to detect biofilm. There are a few biofilm detection and biofilm production methods on prosthetics, methods for screening antibacterial effect of agents against biofilm-embedded microorganism and antibiofilm effect of agents against biofilm production and mature biofilm. The aim of this chapter is to overview direct and indirect methods such as microscopy, fluorescent in situ hybridization, and Congo red agar, tube method, microtiter plate assay, checkerboard assay, plate counting, polymerase chain reaction, mass spectrometry, MALDI-TOF, and biological assays used by antibiofilm researches.",book:{id:"8427",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods"},signatures:"Sahra Kırmusaoğlu",authors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"}]},{id:"62553",title:"Antibiotic Use in Poultry Production and Its Effects on Bacterial Resistance",slug:"antibiotic-use-in-poultry-production-and-its-effects-on-bacterial-resistance",totalDownloads:7327,totalCrossrefCites:43,totalDimensionsCites:92,abstract:"A surge in the development and spread of antibiotic resistance has become a major cause for concern. Over the past few decades, no major new types of antibiotics have been produced and almost all known antibiotics are increasingly losing their activity against pathogenic microorganisms. The levels of multi-drug resistant bacteria have also increased. It is known that worldwide, more than 60% of all antibiotics that are produced find their use in animal production for both therapeutic and non-therapeutic purposes. The use of antimicrobial agents in animal husbandry has been linked to the development and spread of resistant bacteria. Poultry products are among the highest consumed products worldwide but a lot of essential antibiotics are employed during poultry production in several countries; threatening the safety of such products (through antimicrobial residues) and the increased possibility of development and spread of microbial resistance in poultry settings. This chapter documents some of the studies on antibiotic usage in poultry farming; with specific focus on some selected bacterial species, their economic importance to poultry farming and reports of resistances of isolated species from poultry settings (farms and poultry products) to essential antibiotics.",book:{id:"6978",slug:"antimicrobial-resistance-a-global-threat",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A Global Threat"},signatures:"Christian Agyare, Vivian Etsiapa Boamah, Crystal Ngofi Zumbi and\nFrank Boateng Osei",authors:[{id:"182058",title:"Dr.",name:"Christian",middleName:null,surname:"Agyare",slug:"christian-agyare",fullName:"Christian Agyare"},{id:"261271",title:"MSc.",name:"Crystal Ngofi",middleName:null,surname:"Zumbi",slug:"crystal-ngofi-zumbi",fullName:"Crystal Ngofi Zumbi"},{id:"261272",title:"MSc.",name:"Frank Boateng",middleName:null,surname:"Osei",slug:"frank-boateng-osei",fullName:"Frank Boateng Osei"},{id:"261273",title:"Dr.",name:"Vivian Etsiapa",middleName:null,surname:"Boamah",slug:"vivian-etsiapa-boamah",fullName:"Vivian Etsiapa Boamah"}]},{id:"65914",title:"Introductory Chapter: The Action Mechanisms of Antibiotics and Antibiotic Resistance",slug:"introductory-chapter-the-action-mechanisms-of-antibiotics-and-antibiotic-resistance",totalDownloads:4428,totalCrossrefCites:6,totalDimensionsCites:10,abstract:null,book:{id:"8427",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods"},signatures:"Sahra Kırmusaoğlu, Nesrin Gareayaghi and Bekir S. Kocazeybek",authors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"},{id:"248288",title:"Prof.",name:"Bekir",middleName:null,surname:"Kocazeybek",slug:"bekir-kocazeybek",fullName:"Bekir Kocazeybek"},{id:"406463",title:"Dr.",name:"Nesrin",middleName:null,surname:"Gareayaghi",slug:"nesrin-gareayaghi",fullName:"Nesrin Gareayaghi"}]},{id:"50992",title:"Probiotics: A Comprehensive Review of Their Classification, Mode of Action and Role in Human Nutrition",slug:"probiotics-a-comprehensive-review-of-their-classification-mode-of-action-and-role-in-human-nutrition",totalDownloads:5429,totalCrossrefCites:16,totalDimensionsCites:28,abstract:"Probiotics are live microorganisms that live in gastrointestinal (GI) tract and are beneficial for their hosts and prevent certain diseases. In this chapter, after a complete introduction to probiotics, definition, mechanism of action, and their classification, currently used organisms will be discussed in detail. Moreover, different kinds of nutritional synthetic products of probiotics along with their safety and drug interaction will be noticed. This chapter mentions all clinical trial studies that have been done to evaluate probiotic efficacy with a focus on gastrointestinal diseases.",book:{id:"5193",slug:"probiotics-and-prebiotics-in-human-nutrition-and-health",title:"Probiotics and Prebiotics in Human Nutrition and Health",fullTitle:"Probiotics and Prebiotics in Human Nutrition and Health"},signatures:"Amirreza Khalighi, Reza Behdani and Shabnam Kouhestani",authors:[{id:"179560",title:"Dr.",name:"Amirreza",middleName:null,surname:"Khalighi",slug:"amirreza-khalighi",fullName:"Amirreza Khalighi"},{id:"185238",title:"Dr.",name:"Reza",middleName:null,surname:"Behdani",slug:"reza-behdani",fullName:"Reza Behdani"},{id:"185239",title:"Dr.",name:"Shabnam",middleName:null,surname:"Kouhestani",slug:"shabnam-kouhestani",fullName:"Shabnam Kouhestani"}]},{id:"56849",title:"Physiology and Pathology of Innate Immune Response Against Pathogens",slug:"physiology-and-pathology-of-innate-immune-response-against-pathogens",totalDownloads:6226,totalCrossrefCites:21,totalDimensionsCites:28,abstract:"Pathogen infections are recognized by the immune system, which consists of two types of responses: an innate immune response and an antigen-specific adaptive immune response. The innate response is characterized by being the first line of defense that occurs rapidly in which leukocytes such as neutrophils, monocytes, macrophages, eosinophils, mast cells, dendritic cells, etc., are involved. These cells recognize the pathogen-associated molecular patterns (PAMPs), which have been evolutionarily conserved by the diversity of microorganisms that infect humans. Recognition of these pathogen-associated molecular patterns occurs through pattern recognition receptors such as Toll-like receptors and some other intracellular receptors such as nucleotide oligomerization domain (NOD), with the aim of amplifying the inflammation and activating the adaptive cellular immune response, through the antigenic presentation. In the present chapter, we will review the importance of the main components involved in the innate immune response, such as different cell types, inflammatory response, soluble immune mediators and effector mechanisms exerted by the immune response against bacteria, viruses, fungi, and parasites; all with the purpose of eliminating them and eradicating the infection of the host.",book:{id:"5975",slug:"physiology-and-pathology-of-immunology",title:"Physiology and Pathology of Immunology",fullTitle:"Physiology and Pathology of Immunology"},signatures:"José Luis Muñoz Carrillo, Flor Pamela Castro García, Oscar\nGutiérrez Coronado, María Alejandra Moreno García and Juan\nFrancisco Contreras Cordero",authors:[{id:"214236",title:"Dr.",name:"Jose Luis",middleName:null,surname:"Muñoz-Carrillo",slug:"jose-luis-munoz-carrillo",fullName:"Jose Luis Muñoz-Carrillo"},{id:"216080",title:"Dr.",name:"Alejandra",middleName:null,surname:"Moreno-García",slug:"alejandra-moreno-garcia",fullName:"Alejandra Moreno-García"},{id:"216081",title:"Dr.",name:"Oscar",middleName:null,surname:"Gutiérrez-Coronado",slug:"oscar-gutierrez-coronado",fullName:"Oscar Gutiérrez-Coronado"},{id:"216082",title:"Dr.",name:"Pamela",middleName:null,surname:"Castro-García",slug:"pamela-castro-garcia",fullName:"Pamela Castro-García"},{id:"220717",title:"Dr.",name:"Juan Francisco",middleName:null,surname:"Contreras Cordero",slug:"juan-francisco-contreras-cordero",fullName:"Juan Francisco Contreras Cordero"}]}],onlineFirstChaptersFilter:{topicId:"13",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"83067",title:"Multiplicity in the Genes of Carbon Metabolism in Antibiotic-Producing Streptomycetes",slug:"multiplicity-in-the-genes-of-carbon-metabolism-in-antibiotic-producing-streptomycetes",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.106525",abstract:"Streptomycetes exhibit genetic multiplicity, like many other microorganisms, and redundancy occurs in many of the genes involved in carbon metabolism. The enzymes of the glycolytic pathway presenting the greatest multiplicity were phosphofructokinase, fructose 1,6-bisphosphate aldolase, glyceraldehyde-3-phosphate dehydrogenase, and pyruvate kinase. The genes that encode citrate synthase and subunits of the succinate dehydrogenase complex are the ones that show the greatest multiplicity, while in the phosphoenolpyruvate-pyruvate-oxaloacetate node, only malic enzymes and pyruvate phosphate dikinase present two copies in some Streptomyces. The extra DNA from these multiple gene copies can be more than 50 kb, and the question arises whether all of these genes are transcribed and translated. As far as we know, there is few information about the transcription of these genes in any of this Streptomyces, nor if any of the activities that are encoded by a single gene could be limiting both for growth and for the formation of precursors of the antibiotics produced by these microorganisms. Therefore, it is important to study the transcription and translation of genes involved in carbon metabolism in antibiotic-producing Streptomyces growing on various sugars.",book:{id:"10893",title:"Actinobacteria",coverURL:"https://cdn.intechopen.com/books/images_new/10893.jpg"},signatures:"Toshiko Takahashi, Jonathan Alanís, Polonia Hernández and María Elena Flores"},{id:"82972",title:"Actinomycosis: Diagnosis, Clinical Features and Treatment",slug:"actinomycosis-diagnosis-clinical-features-and-treatment",totalDownloads:4,totalDimensionsCites:0,doi:"10.5772/intechopen.104698",abstract:"Actinomycosis is a filamentous bacterium that forms part of the normal human flora of the gastrointestinal, oropharynx and female genitalia. This indolent infection is characterized by abscess formation, widespread granulomatous disease, fibrosis, cavitary lung lesions and mass-like consolidations, simulating an active malignancy or systemic inflammatory diseases. It is subacute, chronic and variable presentation may delay diagnosis due to its capability to simulate other conditions. An accurate diagnostic timeline is relevant. Early diagnosis of pulmonary actinomycosis decreases the risk of indolent complications. Proper treatment reduces the need for invasive surgical methods. Actinomycosis can virtually involve any organ system, the infection spread without respecting anatomical variables as metastatic disease does, making malignancy an important part of the differential diagnosis. As it is normal gastrointestinal florae, it is difficult to cultivate, and share similar morphology to other organisms such as Nocardia and fungus. It is often difficult to be identified as the culprit of disease. Its true imitator capability makes this infectious agent a remarkable organism within the spectra of localized and disseminated disease. In this chapter, we will discuss different peculiarities of actinomycosis as an infectious agent, most common presentation in different organ systems, and challenging scenarios.",book:{id:"10893",title:"Actinobacteria",coverURL:"https://cdn.intechopen.com/books/images_new/10893.jpg"},signatures:"Onix J. Cantres-Fonseca, Vanessa Vando-Rivera, Vanessa Fonseca-Ferrer, Christian Castillo Latorre and Francisco J. Del Olmo-Arroyo"},{id:"82412",title:"Potential of Native Microalgae from the Peruvian Amazon on the Removal of Pollutants",slug:"potential-of-native-microalgae-from-the-peruvian-amazon-on-the-removal-of-pollutants",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.105686",abstract:"Environmental pollution is a severe and common problem in all the countries worldwide. Various physicochemical technologies and organisms (e.g., plants, microorganisms, etc.) are used to address these environmental issues, but low-cost, practical, efficient, and effective approaches have not been available yet. Microalgae offer an attractive, novel, and little-explored bioremediation alternative because these photosynthetic organisms can eliminate pathogenic microorganisms and remove heavy metals and toxic organic compounds through processes still under study. Our research team has conducted some experiments to determine the bioremediation potential of native microalgae on some pollutant sources (i.e., leachate and wastewater) and its ability to remove hazardous chemical compounds. Therefore, in this chapter, we provide the results of our research and updated information about this exciting topic. Experiments were conducted under controlled culture conditions using several native microalgae species, variable time periods, different pollutant sources, and hazardous chemicals such as ethidium bromide. The results indicated that native microalgae can remove pollutants (i.e., phosphorus, ammonia, etc.) of wastewater, leachate, and some hazardous chemical compounds such as ethidium bromide. In conclusion, native microalgae have an excellent potential for removing several pollutants and, consequently, could be used to develop bioremediation technologies based on native microalgae from the Peruvian Amazon.",book:{id:"11366",title:"Microalgae",coverURL:"https://cdn.intechopen.com/books/images_new/11366.jpg"},signatures:"Marianela Cobos, Segundo L. Estela, Carlos G. Castro, Miguel A. Grandez, Alvaro B. Tresierra, Corayma L. Cabezudo, Santiago Galindo, Sheyla L. Pérez, Angélica V. Rios, Jhon A. Vargas, Roger Ruiz, Pedro M. Adrianzén, Jorge L. Marapara and Juan C. Castro"},{id:"81859",title:"Respiratory Syncytial Virus",slug:"respiratory-syncytial-virus",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.104771",abstract:"Respiratory Syncytial Virus (RSV)-driven bronchiolitis is one of the most common causes of pediatric hospitalization. Every year, we face 33.1 million episodes of RSV-driven lower respiratory tract infection without any available vaccine or cost-effective therapeutics since the discovery of RSV eighty years before. RSV is an enveloped RNA virus belonging to the pneumoviridae family of viruses. This chapter aims to elucidate the structure and functions of the RSV genome and proteins and the mechanism of RSV infection in host cells from entry to budding, which will provide current insight into the RSV-host relationship. In addition, this book chapter summarizes the recent research outcomes regarding the structure of RSV and the functions of all viral proteins along with the RSV life cycle and cell-to-cell spread.",book:{id:"11369",title:"RNA Viruses Infection",coverURL:"https://cdn.intechopen.com/books/images_new/11369.jpg"},signatures:"Sattya Narayan Talukdar and Masfique Mehedi"},{id:"82148",title:"Mosquito Population Modification for Malaria Control",slug:"mosquito-population-modification-for-malaria-control",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.104907",abstract:"Malaria is a mosquito-borne disease that kills millions of people every year. Existing control tools have been insufficient to eliminate the disease in many endemic regions and additional approaches are needed. Novel vector-control strategies using genetic engineering to create malaria-resistant mosquitoes (population modification) can potentially contribute a new set of tools for mosquito control. Here we review the current mosquito control strategies and the development of transgenic mosquitoes expressing anti-parasite effector genes, highlighting the recent improvements in mosquito genome editing with CRISPR-Cas9 as an efficient and adaptable tool for gene-drive systems to effectively spread these genes into mosquito populations.",book:{id:"11379",title:"Mosquito Research - Recent Advances in Pathogen Interactions, Immunity, and Vector Control Strategies",coverURL:"https://cdn.intechopen.com/books/images_new/11379.jpg"},signatures:"Rebeca Carballar-Lejarazú, Taylor Tushar, Thai Binh Pham and Anthony James"},{id:"81934",title:"Lactobacillus Use for Plant Fermentation: New Ways for Plant-Based Product Valorization",slug:"lactobacillus-use-for-plant-fermentation-new-ways-for-plant-based-product-valorization",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.104958",abstract:"Today, plant production is increasing, but most industrial processes generate a lot of waste and by-products for which, in the current context, it is a priority to recycle or valorize them. One of the cheapest valorization routes is fermentation, in particular lactic fermentation by Lactobacillus species, which produces lactic acid and other molecules of industrial interest such as bioactive compounds such as anthocyanin, organic acid, peptides, or phenol, which are widely found in the plant matrix, mainly in cereals, grass, fruits, and vegetables. Bioactive compounds may exert beneficial health effects, such as antioxidant, anti-inflammatory, antimicrobial, or prebiotic activities. In addition, lactic acid fermentation can improve existing products and lead to new applications in food, livestock feeding and biotechnology, such as the production of lactic acid, protein, or silage. This chapter reviews the use of Lactobacillus strains in the fermentation process of many plant bioresources or by-products through their different bioactivities, active molecules, and applications.",book:{id:"11372",title:"Lactobacillus - A Multifunctional Genus",coverURL:"https://cdn.intechopen.com/books/images_new/11372.jpg"},signatures:"Morgan Le Rouzic, Pauline Bruniaux, Cyril Raveschot, François Krier, Vincent Phalip, Rozenn Ravallec, Benoit Cudennec and François Coutte"}],onlineFirstChaptersTotal:102},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"23",title:"Education and Human Development",doi:"10.5772/intechopen.100360",issn:null,scope:"\r\n\tEducation and Human Development is an interdisciplinary research area that aims to shed light on topics related to both learning and development. 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",coverUrl:"https://cdn.intechopen.com/series/covers/23.jpg",latestPublicationDate:"August 12th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"280770",title:"Dr.",name:"Katherine K.M.",middleName:null,surname:"Stavropoulos",slug:"katherine-k.m.-stavropoulos",fullName:"Katherine K.M. Stavropoulos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRdFuQAK/Profile_Picture_2022-05-24T09:03:48.jpg",biography:"Katherine Stavropoulos received her BA in Psychology from Trinity College, in Connecticut, USA and her Ph.D. in Experimental Psychology from the University of California, San Diego. She completed her postdoctoral work at the Yale Child Study Center with Dr. James McPartland. Dr. Stavropoulos’ doctoral dissertation explored neural correlates of reward anticipation to social versus nonsocial stimuli in children with and without autism spectrum disorders (ASD). She has been a faculty member at the University of California, Riverside in the School of Education since 2016. Her research focuses on translational studies to explore the reward system in ASD, as well as how anxiety contributes to social challenges in ASD. She also investigates how behavioral interventions affect neural activity, behavior, and school performance in children with ASD. She is also involved in the diagnosis of children with ASD and is a licensed clinical psychologist in California. She is the Assistant Director of the SEARCH Center at UCR and is a faculty member in the Graduate Program in Neuroscience.",institutionString:null,institution:{name:"University of California, Riverside",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:2,paginationItems:[{id:"89",title:"Education",coverUrl:"https://cdn.intechopen.com/series_topics/covers/89.jpg",isOpenForSubmission:!1,editor:{id:"260066",title:"Associate Prof.",name:"Michail",middleName:null,surname:"Kalogiannakis",slug:"michail-kalogiannakis",fullName:"Michail Kalogiannakis",profilePictureURL:"https://mts.intechopen.com/storage/users/260066/images/system/260066.jpg",biography:"Michail Kalogiannakis is an Associate Professor of the Department of Preschool Education, University of Crete, and an Associate Tutor at School of Humanities at the Hellenic Open University. He graduated from the Physics Department of the University of Crete and continued his post-graduate studies at the University Paris 7-Denis Diderot (D.E.A. in Didactic of Physics), University Paris 5-René Descartes-Sorbonne (D.E.A. in Science Education) and received his Ph.D. degree at the University Paris 5-René Descartes-Sorbonne (PhD in Science Education). His research interests include science education in early childhood, science teaching and learning, e-learning, the use of ICT in science education, games simulations, and mobile learning. He has published over 120 articles in international conferences and journals and has served on the program committees of numerous international conferences.",institutionString:"University of Crete",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}},editorTwo:{id:"422488",title:"Dr.",name:"Maria",middleName:null,surname:"Ampartzaki",slug:"maria-ampartzaki",fullName:"Maria Ampartzaki",profilePictureURL:"https://mts.intechopen.com/storage/users/422488/images/system/422488.jpg",biography:"Dr Maria Ampartzaki is an Assistant Professor in Early Childhood Education in the Department of Preschool Education at the University of Crete. Her research interests include ICT in education, science education in the early years, inquiry-based and art-based learning, teachers’ professional development, action research, and the Pedagogy of Multiliteracies, among others. 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