This chapter presents the recent literature data data on the problems of etiopathogenesis, cardiac, and obstetric risk of mitral valve prolapsus, as well as the tactics of patients with this pathology. Modern views on the role of genomic, genetic disorders, and metabolomics in violations valvular structures in the etiology and pathogenesis of clinical manifestations of the mitral valve prolapsus. In addition, the data on the peculiarities of pregnancy and childbirth in women with mitral valve prolapsus (miscarriage, cervical incompetence, preeclampsia, fetal growth restriction, placental insufficiency, labor anomaly, and postpartum hemorrhage) are studied. However, ambiguous and sometimes conflicting data on the relationship and the incidence of these complications with mitral valve prolapsus require further research to determine the set of diagnostic and preventive measures.
Part of the book: Structural Insufficiency Anomalies in Cardiac Valves
Currently, the term “melanoma associated with pregnancy” is used, implying the inclusion of all clinical observations of melanoma diagnosis during pregnancy and in the first 2 years after delivery. The management of pregnant women with newly diagnosed melanoma is likewise controversial, especially with regard to the management of women with an advanced melanoma. Thrombotic complications are the most common form of paraneoplastic syndrome, which largely determines the prognosis of the disease. The presented chapter is intended to familiarize practical physicians with the complexities that arise in the management of pregnant women with a developing metastatic disease, with questions of the progression of the disease during pregnancy, with the emergence of severe paraneoplastic complications involving secondary thrombophilia, amaranthine endocarditis, and widespread arterial thrombosis. The possibility of using modern antitumor drugs (Zelboraf) is shown. It is emphasized that in the management of such patients, the need for an effective team of specialists of various profiles is especially high: oncologists, obstetrician-gynecologists, surgeons, hematologists, anesthesiologist-resuscitators, and US and magnetic resonance imaging (MRI) diagnostics.
Part of the book: Cutaneous Melanoma