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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
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\r\n\tDementia has become the leading neurological problem for human beings associated not only with the old population but newer generations as well. Various environmental and genetic factors are reported to be involved in the disease. This book hopes to comprise a detailed discussion on the relationship between different brain areas and cognition. Pathophysiology of dementia containing molecular mechanisms will be explained as well as the memory function that depends on the neuronal circuits among the different brain areas. Other neuronal circuits involved in memory, learning, and dementia will also be discussed. Mechanism of neuronal circuits involved in memory consolidation, the main neurological disorders associated with dementia, dementia screening, and its validation, along with neurophysiological tests, will be covered. Another aspect that this book hopes to cover is the modern therapeutic trends for the management of dementia. Biologics will be changing the therapeutic world of dementia in the near future. We aim to have a project that consists of various cutting-edge technologies that have been adopted for the treatment of dementia.
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Internet of Things (IoT) embody this trend today combining distributed sensing with high connectivity so that wise decisions and actions follow information gathering and analysis [1, 2]. Trillion Sensors is another paradigm onto which IoT is further exploited on the basis that the more extensive or intensive the deployment of sensor networks is, the more fruitful the knowledge that can be derived from them would be [3, 4].
Small dimensions (nanometers to micrometers) are appropriate in the sensitive part of sensors when they need to interact with phenomena or entities equally characterized by such small dimensions (light, molecules, living cells…). An overall small size for the sensors themselves is not devoid of interest either. The smaller they are, the more sustainable their fabrication is in terms of materials and energy, and the more cost-effective they become. Small size is also enabling in itself, e.g. medical implants, as well as convenient, e.g. payloads.
Sensing requires energy. A certain provision of energy autonomy is needed for sensors to be deployed in remote locations, harsh environments, or where they need to remain temporary unattended. Batteries is a common way to provide such autonomy, but their charge is finite impeding long-term autonomy scenarios. Moreover, their recharge, replacement and disposal imply a logistic and environmental burden that will not be affordable when IoT gets to its full extent mobilizing tens of billions of devices and an even larger number of sensors.
Secondary batteries can be kept recharged by coupling them with energy harvesters able to draw energy present in the environment [5]. Heat is abundant in natural scenarios, and waste heat is also abundant in human-made scenarios due to laws of thermodynamics and our profuse use of thermal machines. When such heat gives rise to temperature gradients (a situation as simple as a hot surface exposed to air), thermoelectricity is a convenient way to extract electric energy from them [6, 7].
For that extraction to be optimum, the external thermal gradient needs to be fully transposed into the thermoelectric generator itself. Physical interaction of small devices with their environment may exploit profitably some scale factors when going down in dimensions, but, sometimes, small sizes pose a handicap or challenge for such interaction, too. This is the case when trying to cool down locally a part of a small device by exchanging heat with the surrounding air. This chapter tries to illustrate this point by sharing the issues and strategies the authors have dealt, and are dealing with, in their quest for silicon-based miniaturized thermoelectric generators.
Silicon technology has been developed around an enabling and highly abundant semiconductor material. It is a mature technology apt to mass-production of devices with economy of scale and it is the champion technology of miniaturization. Not surprisingly, it boosted microelectronics in the XX century and nanoelectronics in the XXI century. In addition to the set of techniques that allow the fabrication of integrated circuits by depositing and patterning thin films on a silicon wafer, silicon technologies also developed micromachining techniques that allow carving and shaping the silicon wafers into structures that are able to interact with the environment. Sensors and actuators belong to the latter category. Since energy harvesters are environmental interacting devices and, application-wise, they should not be much larger than the sensors they will feed, it is only logical that their fabrication will similarly benefit from the silicon technologies toolbox. These technologies do not only excel in miniaturization but also in
The traditional thermoelectric generators mentioned above feature a π-architecture, where the π symbol gives a visual clue about how each thermocouple is built assembling vertically two semiconductor pellets (
Silicon technologies are of planar nature. They enable massive parallelism at
The main objective when defining the architecture and the technological route for a
The platform consists of a thin silicon area fabricated by eliminating the silicon beneath it. In order to preserve its thermal isolation from the surrounding bulk silicon, the physical connections between them should be minimized. Such connections are the mechanical supports that keep the platform in place (e.g. ancillary silicon bridges) and the thermoelectric materials themselves (and whatever supports they may need). In order to minimize the thermal conduction of these elements, they must be produced with
Figure 1 shows the schematics for such a device. Any hot surface in which this device is placed will act as a heat source. The top surface will be exposed to air acting as heat sink and will exchange heat with it. Due to their different thermal mass, the bulk rim area will hardly cool down, thus being the hot part of the device, while the platform will experience a larger decrease of temperature becoming the cold(er) part of it.
From left to right and top to bottom: 3D sketch of an integrated planar micro-thermocouple; SEM image of a fabricated device; schematic cross-section of the device identifying the thermally isolated platform and other relevant elements, and the expected heat flow from hot to cold areas in a transversal architecture. The typical area for the platform of the devices discussed is 1 mm2.
With respect to the thermoelectric material, the depicted device follows a uni-leg approach. Two thermoelectric materials are still at play, but a metal one replaces one of the semiconductor legs in order to close the circuit. Some thermoelectric performance is sacrificed because metals behave poorly thermoelectrically (they have higher thermal conductivities and close to zero Seebeck coefficients), but for the architecture presented and to keep processing simple, the use of a metal leg is technologically convenient.
Regarding the semiconductor thermoelectric material, one distinct feature of our approach is resourcing to silicon materials, namely arrays of silicon nanowires (Si NWs). The rationale behind this option is to attempt the fabrication of
Moreover, arrays of Si NWs can be conveniently grown as a post-process using a
The metal leg cannot be integrated in the same self-standing way. It is deposited as a thin film, so it needs a physical support. These ancillary supports need to be thermally optimized since they bridge the hot and cold areas. The nature of these supports has evolved across the different generations of our devices: from long and thin silicon bridges (400 μm x 100 μm x 15 μm) to wide and very thin Si3N4 membranes (100 μm x 1000 μm x 0.3 μm). Since thermal conductivity of Si3N4 is two orders of magnitude lower than the one of silicon, there is a net gain in thermal conductance, while enabling a shorter and wider (and less electrically resistive) metal leg.
The thermal impact on platform isolation of the
As said, longer NWs generally imply larger ΔT and, thus, a larger thermovoltage. However, a resulting larger voltage is not necessarily associated to a larger power. Power (
It must be noted that the heat transfer issues discussed in this chapter revolve about the challenge of exchanging heat in planar micromachined structures exhibiting very small exchange surfaces [18, 19, 20, 21, 22], while the particular nature of the thermoelectric material employed (e.g. NWs) is of no significance: the same conclusions will apply if silicon membranes, silicon-based thin films, or any other thermoelectric films of interest were considered instead.
When considering the optimum design for a thermoelectric microgenerator (μTEG) the generated power is the parameter which needs to be maximized. It is well known that for a given μTEG with its own internal resistance, the power that is transferred to the load is maximized when the internal resistance and the load resistance are equal. This case is usually known as load matching condition [23].
Considering the electrical circuit diagram shown in Figure 2, which represents a μTEG, formed by a voltage source (VOC) and its internal electrical resistance (RTEG), connected to a load resistance (RL), it is straightforward to evaluate the total dissipated power at the load as:
Equivalent circuit of a μTEG, formed by a voltage source (VOC) and its internal resistance (RTEG), connected in series with a load resistance (RL).
Finding the value of RL which maximizes PL implies after a few calculations the load matching condition, RTEG = RL. It is important to notice that the only parameter allowed to change in this optimization is the load resistance. Therefore, one can write the maximum power as:
As can be seen in Figure 3, where the output power of a μTEG is plotted versus load resistance for three different internal resistances, each curve has a maximum for the load matching condition. But now the influence of the internal resistance is highlighted, where the lower its value, the greater the power output. In Figure 3, for example, halving the internal resistance can double the power output at the load matching condition. This highlights the importance of reducing the internal resistance when designing a μTEG.
Power output of a μTEG versus load resistance for different RTEG values.
Some publications discussing load matching focus on the need to modify the internal resistance, increasing it, in order to match the load resistance [22]. According to Figure 3, this is in fact an error. It is always a better approach to minimize the internal resistance in order to increase the power output even further. Once the internal resistance is the minimum possible, then the load matching condition can be applied to maximize the power output. Actually, many integrated circuits exist which efficiently implement maximum power point tracking (MPPT) algorithms to extract the maximum power from a power source by modifying its load resistance.
This load matching approach can be analogously applied to the temperatures involved in the μTEG and is known as thermal matching. A simplified conductance network describing the μTEG (KTEG) in parallel with KLK accounting for parasitic thermal leakages and in series with KS representing the conductance to ambient (to both heat source and heat sink) is shown in Figure 4.
Simplified thermal conductance network describing the μTEG with parallel and series thermal conductances.
To explore which is the KTEG value that maximizes Pmax, as was done in the electrical case, Eq. (2) can be rewritten as:
Where
Where ΔTA is the total available temperature difference, Tamb-Thot. KTEG is the internal thermal conductance of the μTEG and KS represents the thermal conductance to the ambient.
When decreasing RTEG, as deemed appropriated in the previous paragraphs, it is important to keep in mind that KTEG is bound to increase, as they are inversely proportional. This is because of the implicit assumption that changing KTEG implies a geometry modification, not a material property change and the geometry change affects both electrical resistance and thermal conductance of the μTEG. Ignoring any leakage contribution (KLK = 0 W/K) in Eq. (4), the power output (solid) and ΔT (dotted) versus KTEG can be seen in Figure 5. Three different KS cases have been considered to highlight the fact that, the larger KS, the larger the power output, even for a constant KTEG. It can be seen that when KTEG = KS, the maximum power condition when KLK = 0, then the temperature drop across the μTEG is 50% of the available temperature difference.
Pmax (left, blue curves) and ΔT/ΔTA (right, red curves) versus KTEG for different KS values. For KTEG = 1, thermal matching conditions would call for KS = 1, but larger Pmax values are possible for larger values of KS.
Similar to the electrical case, many papers discussing thermal matching focus on reaching a temperature drop in the μTEG equal to the temperature drop across KS [5, 24, 25]. When this KS represents a heat exchanger, some authors suggest a low KS heat exchanger to match KTEG and therefore maximize the power output according. While this approach assures operation at the mathematical local maximum for a given KS, it is a bad practice because it ignores the absolute maximum, which takes place at larger KS values for a given KTEG.
Looking at Figure 5, if KTEG = 1 W/K, this reasoning would imply that KS = 1 W/K would be necessary, and 50% of the total available temperature difference would drop across the μTEG. However, with a better heat exchanger, KS = 10 W/K or even KS = 100 W/K, then ΔT will asymptotically approach ΔTA, and the power output will asymptotically reach:
In conclusion, both load matching and thermal matching are conditions that are mathematically true, but from a practical point of view, care must be taken when designing a μTEG to maximize its power output. First of all, its electrical internal resistance (RTEG) must be minimized, and after that, power output can be maximized by connecting a load which matches that of the μTEG, or simply an IC implementing an MPPT algorithm. On the thermal side, as RTEG is minimized, the thermal conductance (KTEG) is consequently maximized. Then, as the μTEG is already optimized, and it is not possible to further increase KTEG, the only option is to act on the external components, which in this case is the heat exchanger, and to choose one with an as large as possible KS, so that almost all of the available ΔT will be internally transferred to the μTEG.
As mentioned before, the performance of μTEG devices depends on the temperature difference ‘seen’ by the thermocouples. Therefore, minimizing thermal resistances in series with those elements would improve the performance of the device. In this section, such improvement is demonstrated by decreasing the thermal resistance between the suspended platform and the ambient, usually the cold part, by favoring the heat flow locally. Two methods have been used to increase such heat exchange: (i) by forcing heat convection onto the platform and (ii) by contacting it with a cold mass. The promising results obtained from the experiments described in the next two subsections call for optimizing this effect through the development of a procedure to integrate a heat exchanging structure, which will be shown in section 4.
As the working scenario for the μTEG devices is dominated by a temperature difference between the hot and the cold parts, heat convection could play also an important role on how these temperatures are established. Convection is a mechanism of heat flux originated from the movement of the surrounding fluid, which will be typically air for the usual applications of the presented devices. Depending on how this movement is induced, convection can be classified as natural or forced.
Natural convection is based on the warming up of the air that is close to a heat source that, due to the lowering of its density, tends to move upwards, giving its place to colder air and so promoting the heat exchange. In forced convection, air is forced to move and then renew by an external force.
In order to demonstrate the improvement in the performance of the device, three different sets of experimental measurements have been performed on a device at three different convection conditions. The first one corresponds to natural convection, which occurs when the device is operated by letting it rest on top of a hot surface exposed to ambient at room conditions. The second and third sets of measurements correspond to forced convection regimes. In the second case, this is accomplished by the use of a standard CPU fan (see Figure 6) placed over the device, while in the third, an air jet, obtained through a syringe connected to the compressed air line in the laboratory, is directed towards the device. More details are available at [26].
Experimental setup used for the thermoelectrical characterization of μTEG devices under a forced convection regime induced by a CPU fan located on the top. The device is mounted on the thermal chuck of a Linkam station.
Such experimental measurements have been performed on two different devices, featuring 30 and 60 μm long silicon NWs (by filling 3 and 6 trenches as described in section 2.1). Consequently, each one of the devices has different electrical and thermal resistances.
The obtained experimental results are shown in Figure 7. The devices have been measured at different temperatures of the hot plate (from 50 to 200 °C in 25 °C steps).
Maximum power versus chip surface temperature for three different heat convection regimes and on two different devices (adapted from [
The measurement results show a very clear improvement in the performance as a result of forced convection. The maximum output power obtained when the device is mounted under the fan is multiplied by 3 when compared with the natural convection regime, while when under the more directed and higher flow air jet, the performance increases nearly three orders of magnitude: from a few nW to almost 0.7 μW. Moreover, the more performant air convection is, the less relevant become the thermal properties of the thermoelectric material. In natural and air forced convection cases, the larger output power corresponds to the longest nanowires, whereas in the air jet forced convection the opposite is true. This happens because the longer nanowires also have a larger electrical resistance, and its larger thermal resistance is not significant in this case where the platform to ambient thermal resistance is enough to assure a large ΔT.
In the previous subsection, it has been experimentally demonstrated how important a good thermal connection with the surrounding ambient is in order to improve the overall performance of μTEG devices. Nevertheless, forced convection scenarios are not always available and artificially forcing them needs additional energy consuming devices. Therefore, in order to explore a passive strategy to diminish the thermal resistance to the surrounding ambient, the effect of contacting the microplatform with a metallic probe has been assessed. With this experiment, the feasibility of the addition of a heat exchanging structure as a general strategy for the reduction of the thermal resistance to the ambient will be demonstrated.
The experimental setup consists of a metallic probe dipped in thermally conducting paste, which is carefully positioned on the micro-platform by the use of a micro-manipulator.
The performance improvement obtained by means of this approach can be observed in Figure 8, which shows a plot of the Seebeck voltage output of the device placed on a hot plate at 150 °C when the cold finger is being attached. It can be observed that the voltage increases rapidly after contact, and it rises even more when the applied force to the cold finger is increased slightly, so demonstrating the reduction of the thermal resistance when the physical contact is improved.
Voltage evolution while the cold finger is being attached and detached.
In Figure 9 the power curves obtained from the same device at a hot plate temperature of 250 °C with and without the cold finger are shown. It can be seen an important improvement in the performance of two orders of magnitude, from 1.3 to 142 nW, so proving the effectiveness of the cold finger approach as a proof of concept validating the further development of more effective heat exchanging structures.
Power curves for a device, with and without the cold finger, on a hot plate at 250 °C.
The previous section highlights the importance of physically contacting the platform in order to improve heat extraction, and thus cooling it more efficiently. According to section 2.2 and the results shown in section 3.2, the need for a heat exchanger has been proven. In this section, we study the implementation of such component on the μTEG. This poses several problems from the technological point of view, especially considering the starting device architecture used to expose the thermoelectric material to a thermal gradient. The thermally isolated platform is a fragile structure and physically contacting it without caution might break it. A proper methodology with auxiliary components needs to be developed components to provide such contact safely.
The approach implies to have a thermally conductive piece contacting the platform and interfacing this part of the device with a heat exchanger of appropriate size. For this reason, such piece will be dubbed as ‘adapter’. The contact needs to be compliant to absorb any excess vertical displacement with deformation. The compliant part of this contact will be a certain amount of silver paste. A rigid spacer (PMMA), sitting both on the silicon bulk rim and the platform, will also be necessary to limit the maximum excursion of the adapter over the platform so that pressure between the heat exchanger on top and the platform below can be applied in a safe way. Finally, the heat exchanger itself, a commercial one of similar footprint is assembled onto our chip. In this case, our chip is 7x7 mm2 and the smallest commercial heat exchanger found is 8x8 mm2. A PCB with a through-hole, to insert a copper plate improving the thermal conductance from the hot surface to the bulk silicon rim, and a slightly larger partial etch to fit the chip and facilitate the wire bonding to auxiliary copper traces, are included in the assembly as shown in Figure 10.
Isometric, cross section and detailed view of the proposed approach to safely contact the thin silicon platforms.
The feasibility of the approach has been first tested building a physical model and solving finite element simulations (COMSOL) to evaluate the expected improvement on performance. The thermal and electrical properties of the materials used in the model are listed in Table 1.
κ (W·m−1·K−1) | σ (S·m−1) | S (V·K−1) | |
---|---|---|---|
Silicon | 150 | 12·103 | |
Silicon oxide | 1.4 | — | |
Silicon nitride | 30 | — | |
Silicon NWs | 25 (1) | 12·103 (1) | 250·10−6 |
Tungsten | 174 | 7.76·106 (2) | |
Thermal paste | 5 | — | |
Copper | 401 | — | |
FR4 (PCB) | 0.3 | — | |
Spacer (PMMA) | 0.2 | — |
Thermal and electrical properties of the materials used in the model.
Silicon NWs are modeled as a block, not individual nanowires, and the block material properties assume an occupation of only 5% of the total area with nanowires, while the remaining 95% has air material properties.
Tungsten electrical conductivity is different from the bulk literature values. The sheet resistance on a real device has been measured to obtain this value.
The model boundary conditions include a constant hot temperature at the bottom (Thot = 100 °C) and natural convection on the vertical and horizontal walls of the heat exchanger through a heat exchange coefficient directly calculated in COMSOL for an air ambient temperature of 27 °C. When such element is not present, the heat exchange coefficient is applied directly on the platforms surface. Figure 11 shows the temperature distribution for the whole model under such conditions. As it can be seen, even with a heat exchanger, the lowest temperature reached in the cold part is slightly below 70 °C although the ambient temperature is 27 °C. This is because the thermal resistance from the heat exchanger to the ambient is approximately one third of the total thermal resistance while the thermal resistance from the bottom of the PCB (actually most of this is from the silicon chip) to the heat exchanger is approximately two thirds of it.
Temperature distribution for the whole model with Thot = 100 °C.
The internal temperature distribution for chips with four platforms with NW lengths of 10, 20, 30 and 40
Temperature distribution for each platform (from T1 to T4) without heat exchanger (left) and with heat exchanger (right).
On the other hand, for the case without heat exchanger (left), the temperature differences across the nanowires do not reach beyond 2 °C. In this case, the thermal resistance to the ambient is much larger than the nanowires thermal resistance, and a very small temperature drop develops across the active thermoelectric material.
If the temperature solution from the finite element model is coupled to an electrical model through the Seebeck coefficient of the nanowires, the I-V curves and power output for each platform considering both scenarios can be obtained.
These results are shown in Figure 13, where the power output has been plotted as power density considering a device area of 2 mm2, large enough to contain the whole platform (approximately 1 mm2) and space for additional contacts.
I-V curves (solid lines), and power output (dotted lines), versus current for T1-T4 devices, without (left) and with heat exchanger (right).
Clearly, a much larger power is obtained when the heat exchanger is in place due to the much higher ΔT perceived by the NWs. In addition, the behavior of the four platforms evolve differently. Without the heat exchanger, voltage and power scale with the length of nanowires since their thermal resistance is the dominant part of the total device thermal resistance and such length is directly determining the attained ΔT. However, when the presence of the heat exchanger secures most of ΔT, the positive effect of the lower thermal conductance of longer nanowires, which is still there, rapidly saturates and even reverse (see T4 vs. T3) because the detrimental impact of the increasing electrical resistance becomes dominant.
The significant increase in the generated power when applying a forced convection or a cold finger and the results from the simulations including a heat exchanger directed our efforts to the construction of the previously described heat exchanger assembly on our μTEGs (see Figure 10).
The preparation sequence of the required components is given in Figure 14a. A heat exchanger adapter is made from four Cu wires (one per on-chip a device), with diameter similar to the size of the suspended platform (which they will contact after the assembly) inserted in a square brass piece and machined to the appropriate length. The tips of the wires are dipped with thermal paste (Figure 14b) to fill the gap between the Cu wires and the suspended platforms to guarantee good thermal contact (Figure 14c). A PMMA spacer with a thickness appropriately matching the length of the protruding Cu wires is then assembled between the heat exchanger adapter and the μTEG, and finally, the aluminum heat exchanger is placed on top of adapter using a thermal paste (Figure 14d). Further details can be found in [27] from which Figures 14–17 have been adapted.
(a) Steps of the construction of the heat sink adapter. Optical microscope images of (b) the Cu wire dipped in thermal paste and (c) the footprint left on the platform of the test device. (d) An image of the final assembly.
Through the described integration scheme, a first evaluation of the performance improvement brought by a heat exchanger to the μTEG is enabled. In this study harvesting measurements with and without heat exchanger were performed by placing the assembled devices on a Linkam THMS 350 V heating stage at various temperatures in a natural convection environment. Three different cases were measured: without heat sink, with heat sink and with heat sink + pressing, where for the latter a force is applied on top of the assembly to reduce the thermal resistance of the thermal paste. Chips with different thermoelectric materials were measured: Si NWs, Si-Ge NWs and Si microbeams. At the current stage of technology maturity, a rather low number of devices has been measured, but the results shown in the next subsections correspond to significant devices of each category. In terms of measurement uncertainties, the most important source are thermal fluctuations that due to the thermoelectric nature of the device introduce variations in the measured V and I, which have been estimated to be below 10 μV and 1 μA, respectively.
The Seebeck voltage vs. hotplate temperature curves for the Si NWs-based μTEGs with different number of trenches are shown in Figure 15. As anticipated, all the devices presented output voltages that scaled with the number of trenches (i.e. length of NWs). However, the reduction of the thermal resistance between the cold side (suspended platform) and the ambient when a heat exchanger is integrated resulted in a large increase of ∆T across the NWs and hence higher overall voltages.
Seebeck voltage vs. hot plate temperature for Si NWs-based μTEGs with different number of trenches (T1-T4) with and without heat exchanger.
In terms of power, the maximum power densities obtained at hot plate temperatures of 100 °C without the heat exchanger were in the range of 0.05–0.1 μWcm−2. As expected, a tremendous increase in power density was observed after the integration of the heat exchanger + pressing, and values in the range 7–42 μWcm−2 were observed. No clear trends were observed with the number of trenches.
For devices with SiGe NWs, considerable higher Seebeck voltages were observed when compared to Si NWs (Figure 16), due to the higher thermal resistance resulting from the lower intrinsic thermal conductivity of the former. With and without heat exchanger, the devices performed better with increasing number of trenches. Also, power densities rose considerably with the integration of the heat exchanger. As already observed for the Si NWs, the voltage and generated power improved further when a slight pressure was applied to the heat exchanger, It is worth noticing that the maximum power thus obtained does not differ much for Si and SiGe NWs: 41.6 μWcm−2 vs. 45.2 μWcm−2, respectively, considering a T3 device on a hotplate at 100 °C. This points to the dilution of the effect of better starting thermal properties when the heat exchanger is present.
Seebeck voltage vs. hot plate temperature for SiGe NWs-based μTEGs with different number of trenches (T1-T3) with and without heat exchanger.
Si microbeams devices were fabricated to compare the performance of bulk Si with Si NWs. After the integration of the heat exchanger + pressing, the results presented in Figure 17 show a remarkable three orders of magnitude increase in the generated power from ∼650 pW to ∼690 nW for a T1 device, i.e. from 32.5 nWcm−2 to 34.5 μWcm−2. This result evidences again that once the heat exchanger is in place, the thermal properties of the thermoelectric material become second order. Hence, by optimizing their electrical properties and ensuring a good ∆T with the aid of a heat exchanger, it is possible to obtain high power densities even with high thermal conductivity thermoelectric materials such as Si microbeams.
I-V and power curves for the Si microbeams based μTEGs without heat exchanger (left) and with heat exchanger and pressing (right) for a hot plate temperature of 100 °C.
In order to translate the promising power densities of a single structure into useful absolute power levels, a certain number of thermocouples needs to be integrated and connected. The μTEGs design was modified to attain a higher integration density by reducing the number of active sides. The new thermocouple has a rectangular shape with one side featuring the membrane providing mechanical support and metallic connection, and the opposite side composed of the trenches to be filled with NWs. In Figure 18, a 3D schematic of the new unitary thermocouple is shown. The same cross-section profile of Figure 1 still applies. With this new design, many elements can be integrated in the same chip: up to fifty thermocouples (each with an approximate size of 5 x 0.6 mm2) fit in series or series–parallel configuration in a 49 mm2 chip, as shown in Figure 19. Both configurations would lead to the same harvested power, but the series one will scale up voltage while the parallel one will scale up current.
3D schematic of the new thermocouple design (left) and an optical microscope image of the fabricated micromachined platform.
Layout of the new compact design featuring 50 thermocouples in serial connection (left) and serial connection of 10 arrangements of 5 thermocouples in parallel configuration (right).
This compact design requires new components and a novel and more efficient approach for the integration of the heat exchanger in order to boost their thermal performance. A micromachined Si adapter (substituting the Cu wires, brass plate and PMMA spacer of the previous section) is necessary for the distribution of the force exerted on the platform by the heat exchanger, and different designs featuring the corresponding serial or parallel arrangements were fabricated. Figure 20 (left) depicts the Si adapter designs where the central columns contact the platform of each thermocouple in the chip and the ones at the corners act as force distributers. Similar to the previous section, a commercial Al mini heat exchanger will be placed on top of the Si adapter to help the circulation of heat from the Si rim of the μTEG (warm side) through the thermoelectric material to the platform (cold side) to achieve the desired larger ΔT. The heat flux representation through the assembly is shown in Figure 20 (right).
Schematic of the different designs of the micromachined Si adapter (left). Heat flux through a parallel type μTEG, the adapter and the heat exchanger (right).
To achieve a good thermal contact, which is key for a maximum generated power, a thermal interface material (TIM) needs to be placed between the thermocouple and the adapter. To this aim, an inkjet printer (Dimatix) was chosen to deposit a controlled amount of TIM only on the columns of the adapter.
After dispensing the TIM, the adapter is placed face-down onto the thermocouple chip already wirebonded on a PCB. This is done with the help of a pick & place machine (Finetech) that enables proper chip alignment and attachment with a controlled gentle force (0.1 N). A holder with a removable lid for the adequate handling of the Si adapter during the process has been designed and 3D-printed. It allows accessing the corresponding side of the adapter, first to the inkjet printer, and then to the pick & place machine. The whole assembly process is depicted in Figure 21.
New assembly route of the heat exchanger Si adapter onto the encapsulated μTEGs chip.
This is a still ongoing process. Two different inks are being tested to act as TIM between the adapter and the suspended platforms: a conductive silver nanoparticle ink (Agfa Orgacon SI-J20X) and a SU8 based polymeric ink (Micro Chem Prielex). The tests involve the assessment of the adequacy of the viscosity and adhesion of the TIM and the evaluation of the endurance of the μTEGs platforms during the assembly. Other TIM materials already used for the mainstream attachment of heat exchangers onto microprocessors can be also evaluated, as well as other ways of locally dispensing them, such as stamping. In any case, the goal is to obtain an integration route for the heat exchanger, without which no workable ∆T would be possible in such miniaturized devices, that is prone to the automatic handling of the involved chips and it is compatible with their dimensional and mechanical endurance constraints.
With this chapter, the authors have tried to show the challenges to sort out when fabricating microgenerators (μTEGs) with planar silicon technologies. Such technologies offer a cost effective way of mass-production of miniaturized devices. However, the very nature of such technologies, the high thermal conductivity of bulk silicon and the typical thickness of the layers involved advises using silicon micromachining to enable areas of lateral thermal contrast. Such transversal architectures helps to translate naturally occurring vertical thermal gradients into internal lateral ones. In this way, a temperature difference will develop across a horizontally and self-standing laid thermoelectric material whose length is a design parameter. A material properties trade-off ensues: the longer the material, the higher its thermal resistance, increasing the attainable ΔT and the obtained Seebeck voltage, but the larger will be its electrical resistance, reducing the power obtainable from that voltage. In addition, it has been shown that the overall attainable ΔT is heavily influenced by the very poor heat exchange capabilities with the environment of small bare surfaces. Simulations and experiments show that the presence of a heat exchanger largely increase the effective ΔT, but brings into play interesting heterogeneous integration challenges still to be fully solved in terms of an effective but gentle attachment of an intermediate adapter that needs to be designed ad hoc for proper heat flow handling. The presence of the heat exchanger also affects the tilting point of the previously mentioned thermal/electrical trade-off, and thus on the final choice of materials. In the examples given, silicon-based materials have been used (silicon microbeams, silicon and silicon germanium nanowires), but similar structures could be devised for instance for any thermoelectric material in thin film form.
This manuscript contains work supported by projects FP7-NMP-2013-SMALL-7 (Contract n. 604169) SiNERGY, TEC2016-78284-C3-1-R (AEI/FEDER, EU) MINAUTO and TEC2016-78284-C3-2-R (AEI/FEDER, EU) SIGGNAL. This research has made use of the infrastructure of the Spanish ICTS Network MICRONANOFABS (CNM site) partially supported by MINECO. I. Donmez-Noyan thanks the ‘Programa de Doctorat en Ciència de Materials de la UAB’ for the support in her formative activities.
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\n\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
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\n\nLast updated: 2020-11-27
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The choice of available treatments depends on tumor characteristics such as biomarkers, tumor size, metastatic disease, ligands, and antigen or endocrine receptor expression. Combined with surgical resection, chemotherapy and radiation remain the first line of treatment for patients with cancer. Even with these treatments, however, cancer continues to have high fatality rates and current therapeutic modalities have yet to significantly improve the often dismal prognosis of this disease. Nanotechnology is a highly focused approach, which may provide more effective and less toxic treatment when compared to chemotherapy. This area of research has emerged as cancer treatment in the form of new drugs and has reached promising results in preclinical and clinical trials proving its value as a potential tumor therapy.",book:{id:"5431",slug:"breast-cancer-from-biology-to-medicine",title:"Breast Cancer",fullTitle:"Breast Cancer - From Biology to Medicine"},signatures:"Márcia Rocha, Natalia Chaves and Sônia Báo",authors:[{id:"147895",title:"Dr.",name:"Sônia Nair",middleName:null,surname:"Báo",slug:"sonia-nair-bao",fullName:"Sônia Nair Báo"},{id:"190527",title:"MSc.",name:"Natalia",middleName:null,surname:"Chaves",slug:"natalia-chaves",fullName:"Natalia Chaves"},{id:"190529",title:"MSc.",name:"Marcia",middleName:null,surname:"Oliveira Da Rocha",slug:"marcia-oliveira-da-rocha",fullName:"Marcia Oliveira Da Rocha"}]}],mostDownloadedChaptersLast30Days:[{id:"53856",title:"Early-Stage Progression of Breast Cancer",slug:"early-stage-progression-of-breast-cancer",totalDownloads:1706,totalCrossrefCites:4,totalDimensionsCites:4,abstract:"Breast cancer can be defined as a group of diseases with heterogeneous origins, molecular profiles and behaviors characterized by uncontrolled proliferation of cells within the mammary tissue. Around one in eight women in the US will develop breast cancer in their lifetime, making it the second most frequently diagnosed cancer behind skin cancer [1]. In 2015, an estimated 231,840 cases of invasive carcinoma were diagnosed, and over 40,000 deaths were caused by breast cancer which accounts for almost 7% of all cancer mortality each year. In 2015, 60,290 cases of in situ breast cancer were diagnosed, representing over 14% of all new cancer cases among women and men. The steep increase in diagnosis of early‐stage breast cancer over the past 10 years is believed to be a result of more frequent mammography. However, since over half of these in situ lesions will not progress to invasive breast cancer, controversies have arisen about approaches to treatment and prevention of progression of early‐stage in situ breast cancer. Understanding the mechanisms of transition of normal breast to in situ pre‐neoplastic lesions and invasive breast cancer is currently a major focus of breast cancer research with implications for preventive and clinical management of breast cancer. In this review, we give an overview of current knowledge on the molecular and pathological changes that occur during early‐stage progression of breast cancer and describe some of the current models that are used to study this process.",book:{id:"5431",slug:"breast-cancer-from-biology-to-medicine",title:"Breast Cancer",fullTitle:"Breast Cancer - From Biology to Medicine"},signatures:"William Kietzman, Anna T. 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Fentiman",authors:[{id:"119147",title:"Prof.",name:"Ian",middleName:null,surname:"Fentiman",slug:"ian-fentiman",fullName:"Ian Fentiman"}]},{id:"52969",title:"Histopathological Characteristics: Clinical Course of Breast Cancer Subtypes Depending on the ER(+) (−)/PR(+) (−) Receptor Status",slug:"histopathological-characteristics-clinical-course-of-breast-cancer-subtypes-depending-on-the-er-pr-r",totalDownloads:1902,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Breast cancer patients were divided into separate groups, which were the estrogen receptor (ER)+/progesterone receptor (PR)+ HER2−, the ER or PR+ HER2−, the ER+/PR+ HER2+, the ER or PR+ HER2+, the ER−/PR− HER2−, and the ER−/PR− HER2+ groups. Patients with the ER/PR(+)/HER2− subtype breast cancers show better clinical prognosis compared to the hormone-negative, triple-negative (TN), and HER2+ subtypes. TN, HER2+ tumors in postmenopausal women were of higher grade, showing lymph node and lymphovascular invasion with poor prognosis in all case series. However, the ER+/PR−/HER2+ subgroup had the lowest survival rates in 2- and 5-year follow-ups. Comparison between the ER+PR+HER2+ and ER+PR−HER2− subgroups showed that HER2− status is an indicator of improved prognosis in long-term follow-up. Single hormone receptor (HR)(+) status, particularly HER2(−) cases, was in between the favorable and poor survival subgroups. The ER−, PR−, and HER2+ properties were found to be risk factors for frequent recurrences. In this chapter, breast cancer subtypes are compared with each other. 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His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. 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He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"28",type:"subseries",title:"Animal Reproductive Biology and Technology",keywords:"Animal Reproduction, Artificial Insemination, Embryos, Cryopreservation, Conservation, Breeding, Epigenetics",scope:"The advances of knowledge on animal reproductive biology and technologies revolutionized livestock production. Artificial insemination, for example, was the first technology applied on a large scale, initially in dairy cattle and afterward applied to other species. Nowadays, embryo production and transfer are used commercially along with other technologies to modulate epigenetic regulation. Gene editing is also emerging as an innovative tool. This topic will discuss the potential use of these techniques, novel strategies, and lines of research in progress in the fields mentioned above.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11417,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). She is the head of the Reproduction and Embryology Laboratories and was lecturer of Reproduction and Reproductive Biotechnologies at Veterinary Medicine Faculty. She has over 25 years of experience working in reproductive biology and biotechnology areas with a special emphasis on embryo and gamete cryopreservation, for research and animal genetic resources conservation, leading research projects with several peer-reviewed papers. Rosa Pereira is member of the ERFP-FAO Ex situ Working Group and of the Management Commission of the Portuguese Animal Germplasm Bank.",institutionString:"The National Institute for Agricultural and Veterinary Research. 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Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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