Routes for administration of AIT, showing the advantages and disadvantages of each route.
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"2112",leadTitle:null,fullTitle:"Soil Health and Land Use Management",title:"Soil Health and Land Use Management",subtitle:null,reviewType:"peer-reviewed",abstract:"Soils play multiple roles in the quality of life throughout the world, not only as the resource for food production, but also as the support for our structures, the environment, the medium for waste disposal, water, and the storage of nutrients. A healthy soil can sustain biological productivity, maintain environmental quality, and promote plant and animal health. Understanding the impact of land management practices on soil properties and processes can provide useful indicators of economic and environmental sustainability. The sixteen chapters of this book orchestrate a multidisciplinary composition of current trends in soil health. Soil Health and Land Use Management provides a broad vision of the fundamental importance of soil health. In addition, the development of feasible management and remediation strategies to preserve and ameliorate the fitness of soils are discussed in this book.\nStrategies to improve land management and relevant case studies are covered, as well as the importance of characterizing soil properties to develop management and remediation strategies. Moreover, the current management of several environmental scenarios of high concern is presented, while the final chapters propose new methodologies for soil pollution assessment.",isbn:null,printIsbn:"978-953-307-614-0",pdfIsbn:"978-953-51-4923-1",doi:"10.5772/2516",price:139,priceEur:155,priceUsd:179,slug:"soil-health-and-land-use-management",numberOfPages:346,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"3065f0ce00f5f86227cc7f2069cdb89a",bookSignature:"Maria C. 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Hernandez-Soriano, PhD, received a BS degree in Chemistry from the University of Granada, Spain, in 2006, where she also completed a MS in Agricultural Sciences in 2007. She carried out her thesis studies within an international agreement between the High Council for Scientific Research in Spain, and the Katholieke Universiteit Leuven in Belgium, under the supervision of Dr MD Mingorance, Dr A. Peña and Prof. E. Smolders, receiving a PhD degree in Bioscience Engineering in June 2009.\nDr Hernandez-Soriano has been awarded with a significant number of fellowships, including a Fulbright Postdoctoral Fellowship to conduct research in North Carolina State University, under the supervision of Prof. D. Hesterberg. She has made a significant number of research contributions that were published in prestigious international peer-reviewed journals in the area of Soil Science, Environmental Sciences, and Chemistry. Her work has been presented internationally in more than 20 conferences. 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\r\n\tCoordinating, orchestrating, and scheduling tasks has been an art practiced by governments, companies, and managers for ages. The rise of Taylorism, standardisation, electrical systems, electronic systems and computing, and now, quantum computing, has given scheduling a whole World of importance.
\r\n\tFrom practice to a mathematical and technological application, scheduling has become another form of art: an algorithmic art, declined in as many OS and hardware constraints, from embedded systems onboard an aircraft or a spacecraft to databases in all financial and Internet servers.
\r\n\tThey have become ubiquitous so that a large part of our civilisational development is supported by their reliability, redundancy, and optimisation capacity. Like all of our civilisational assets, they are benefiting from scientific breakthrough in computational sciences such as evolutionary algorithms, Artificial Intelligence, and quantum computing. If not by using it, by being in need of adapting to the next generation of computing. Space development is also bringing new challenges, especially in redundancy and reliability.
The aim of this chapter is to review the applications of NLP in business. Advancement in the application of technologies in daily lives has revolutionised communication and interaction between humans and computers. It has also had the same effect on humans throughout the world, for they can now use communicative applications (enabling translation and transliteration). Interaction/communication is an important factor in daily lives, as it is the basis for humans to become involved in activities such as business, education, commerce, healthcare management, politics and socialising. The way in which humans communicate can be referred to as natural language, which includes speech, text and emotions [1]. Humans are more involved in speaking as a means of communication than in writing (text). Text, rather than speech, is important for developing any AI application that facilitates the communication process, as machines, as yet, are not as effective in learning languages as humans, as a result of which, they have to depend on the text/data [2]. A child spends years learning any language, which involves emotions, fluency, grammar and speaking norms, among other things. Hence, it is not an easy task for a computer scientist to build applications that deal with natural language input/output.
The study of language, with regard to its grammar, rules, semantics and phonetics, is referred to as linguistics. Devising rules of language, methods for syntax and semantics are included as part of linguistics study. The methods and rules proposed by theoretical linguists can be processed by computer systems, which generate natural language which cope with such matters as grammar, semantic norms etc. This approach has been referred to as computational linguistics [3], for which statistical approaches are utilised in the process of analysing text/data. However, the approaches for processing natural language may not be limited to statistics, for they could also involve the application of advanced inference methods, like machine learning (ML) and deep learning, which are popular artificial intelligence (AI) techniques. Application of advanced techniques could address various challenges associated with the processing of natural language, such as breaking sentences, tagging the parts of speech (POS), generating dependency graphs, building an appropriate vocabulary, linking different components of vocabulary, setting the context, extracting semantic meanings or transforming unstructured data into a structured format [4, 5, 6].
With the development of technologies and applications of various methods for processing natural language, the understanding and definition of NLP has changed over time. Statistical NLP uses the data generated according to some probability distribution and then makes some inferences about this [7]. In a wider sense, NLP should be able to cover any kind of computer manipulation of natural language: it could be as simple as counting word frequencies to compare different writing styles; or as complex as understanding complete human utterances for delivering responses to an input [8]. Given the application of effective technologies, such as ML, in recent years, for NLP, the most appropriate definition is proposed as:
‘NLP is a collective term referring to automatic computational processing of human languages. This includes both algorithms that take human-produced text as input and algorithms that produce natural looking text as outputs’ [9].
Focusing on the brief background discussed, it can be identified that there is a growing demand and scope for larger application of NLP in various sectors. Therefore, reviewing the applications of NLP in different sectors contributes valuable knowledge to academicians, researchers and industry practitioners working in the areas of NLP applications. Accordingly, the purpose of this chapter is to review the applications of NLP in various business service sectors and provide future directions of NLP applications.
Review chapters could be an important sources of information for academicians and practitioners in guiding their decision-making and work practices [10]. High-quality reviews are cited more frequently [11]; and are found to be downloaded more often than any published article, as they offer a high-quality information from various articles in an effective way [12]. In addition, reviews enable one to have an overview, if not a detailed knowledge of the area in question, as well as references to the most useful primary sources [13].
Literature review, in this aspect, can be very useful in collecting information from various sources such as systematic reviews, theoretical reviews etc. Literature review may be the best methodological tool for gathering evidence in a certain area [14]. As this study focuses on gathering information related to application of NLP in business, it can be considered as explorative study. The approach in literature reviews can be narrow, such as investigating the effect of relationship, or it can be broader, such as exploring collective evidence in relation to a specific area or concept. Literature reviews are identified to be very useful, when the aim of the study is to provide an overview about certain issue. In addition, it can be useful for creating research agendas, identifying gaps in research or simply discussing a particular matter [15]. It can be very beneficial in mapping the development of a particular research field in different contexts over time [16]. Considering the nature of this study, which focuses on investigating the development of NLP and its applications in business, literature review methodology is considered as it is identified as an effective methodological tool. Therefore, this chapter adopted a literature review methodology by collecting the relevant information from various sources of information including academic journals, online articles, conferences, white papers and industry reports. A brief literature review about the development of NLP over time is presented in Section 3. In addition, the information collected regarding NLP applications is categorised into major areas/industries including commerce, E-Governance, healthcare, and education, and other relevant areas as explained in Section 4.
The roots of NLP development can be traced back to 1950s, when the idea ‘can machines think’ was put forward and examined by Alan Turing, which is popularly known as the Turing Test for the creation of intelligence [17]. This study paved the way for research related to the understanding of natural languages and machine translation. However, there was not much progress, for after many experiments, as identified in a 1966 ALPAC report, no one had succeeded in meeting his specified criteria [18, 19]. Some promising NLP systems were developed in the 1960s, which have been updated since through various techniques and new conceptualisations. Some of the major applications in the 1960s included ‘SHRDLU’, a natural language understanding program that allowed user interaction in English terms [20]; and ‘ELIZA’, a NLP program that stimulated human-machine conversation using a pattern matching and substitution methodology [21].
The research during the 1970s was focused on formatting and structuring real-world data into computer understandable data, which was based on conceptual ontologies. Some of the major developed applications included MARGIE, which could read an English sentence, using Riesbeck’s expectation-based parser as well as building a conceptual dependency form, which represented the meaning of the sentence [22]; and QUALM, which used semantic modelling for framing questions and associating them with different strategies to find answers [23]. In the 1980s, most of the applications relied on complex sets of hand-written rules for NLP. By the late 1980s and 1990s, the research was focused on the application of statistical models for making soft and probabilistic decisions based on the input data along with ML algorithms, such as decision-trees [18, 24]. Accordingly, various techniques of ML became popular approaches to NLP, as they could achieve effective results for various NLP tasks, such as modelling and parsing [25, 26, 27, 28]. Other popular techniques utilised in recent years are text embedding to capture the semantic properties of words, deep learning, machine translation and neural machine translation [29] (Figure 1).
Brief history of NLP evolution.
Deep learning has gained momentum in NLP over ML in recent years for various reasons, including the ability to handle larger amounts of training data, the availability of faster machines and multicore CPU/GPUs. Moreover, new models and algorithms with advanced capabilities that have improved performance have stimulated deep learning research [29]. The manually designed features in ML are often over-specified, incomplete and take a long time to design and validate, whereas deep learning’s underpinning parameters are quick to adapt and learn fast. Machine translation on various platforms is one of the classic representations of NLP implementation, the use of which is increasing in various industries and the market is projected to be $56 billion by 2021 [30]. Applications, such as ‘Google Translate’, one of the widely used applications on online platforms; Facebook, using machine translation for translating texts in posts and comments; and eBay, similarly using machine translation for enabling cross-border trade by connecting the users across the world. Neural Machine Translation, which manages the entire process of NLP through an artificial neural network known as a Recurrent Neural Network, has been found to be very effective [31]. Another important breakthrough for NLP application is the delivery of dialogue and conversations through chatbots or virtual assistants, such as Apple Siri, Amazon Alexa and Microsoft Cortana. These are increasingly being used, being continuously updated through ML. In sum, the growth of NLP can be observed with the changing needs and increasing adoption of technologies, being transformed through various techniques, such as rules-based algorithms, statistical models, ML, deep learning and RRN.
Communication is an important factor that builds relationship among individuals, and also between organisations and individuals. Interactions among the people from different countries have been facilitated using translators. However, with the development of NLP, communications between such entities have become easier, with language no longer being a barrier to human and business interactions. Businesses can internationalise their operations, and trade relations can be improved, thereby enhancing global commerce. Application of NLP can be found in a range of business contexts, some of which are described in what follows.
Sentiment analysis is one NLP technique that is widely used in the finance market/trading. It is the process of understanding an opinion about a given subject through written or spoken language and accurate predictions are considered to be a game changer in achieving success on the stock market. Financial analysts, business analysts and trade analysts are employed in the organisations for this purpose, to monitor and analyse the impact of various happenings to stock prices. Their work can be simplified by using NLP with ML and AI techniques, are effective in analysing the data from internet, news, blogs and social networking sites (analysis of huge chunks of data across various channels). They can predict trade fluctuations, which enable investors to take the right decisions at the right time. For instance, when using sentiment analysis, words such as ‘good’, ‘profit’, ‘benefit’, ‘positive’ and ‘growth’ can be tagged with positive value, while those, such as ‘risk’, ‘fall’, ‘bankruptcy’, and ‘loss’ are tagged with negative values. Making meaning from the text identified using NLP and ML allows for accurate predictions to be made [32].
Similarly, NLP’s application in business can be observed in other forms, such as: filtering emails and identifying spam (by analysing text); enhancing security through voice recognition; extracting information from large datasets; using online assistants/chatbots (questioning-answering) for providing customer service; promoting business intelligence; placing relevant ads online by using keyword matching and sense disambiguation; analysing competitors and the market using event extraction techniques, this list being inconclusive [33, 34, 35, 36, 37]. NLP can be applied in E-Commerce/S-Commerce applications for analysing the consumer behaviour based on the feedback, posts, reviews, ratings etc. (text analysis). It can also provide effective customer support through virtual assistants that can respond to customer queries in a range of formats, including: text, speech, audio or video [38].
NLP can enhance E-Governance, which is completely reliant on an information and communication technologies infrastructure [39]. It can facilitate interaction between the citizens and government using an E-Governance framework. For example, citizens who are illiterate can share their opinions and interact with government through audio/video conversation, which can be translated into text for documentation. Similarly, voice-enabled mobile applications can read the text and convey messages to the people. In addition, government can use NLP for monitoring various channels through which people interact to identify their concerns. Moreover, in this context, it can be used for enhanced security, by preventing any breaches of this.
Interactions between citizens and government involve enormous volumes of information exchange. Filtering and formatting such large amounts of data is a complex task, which can be effectively managed by the use of NLP with AI and ML techniques [40]. For instance, sentiment analysis can be used for mining opinions from huge datasets, including feedback, complaints and reviews about a particular policy, thereby ascertaining what the general consensus on it is [41]. That is, it can be used to gauge opinions from feedback, complaints and suggestions made by the residents of a city in relation to various urban issues, such as carbon emissions, lack of a solid waste management system and lack of sanitation [42]. This would help the relevant government agencies in selecting appropriate strategies to address the issues identified. In sum, as a result of adopting these approaches, the communication between government and citizens could be markedly improved, in particular, the former could use them to identify the concerns of the latter and thus, address these in a timely manner. In addition, it encourages E-Participation from both sides, thereby greatly contributing to the effective implementation of government policies.
The healthcare industry is one of the fastest growing. It has been integrating technology applications with healthcare practices, such as diagnosis and treatment for delivering effective and efficient services, which can be accessed by the majority of people, thereby overcoming any regional disadvantages (access in rural areas through E-Health services). However, the amount of data being collected through this process, in the form of such as EHRs (Electronic Health Records), sensor information, diagnoses, monitoring data, healthcare operations and management data is vast. It has been ascertained that about 80% of the healthcare data is unstructured, of poor quality, and considering the current format, it is effectively unusable [40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68]. NLP, in this context, can be considered as one of the effective approaches for addressing these problems by using it to parse information and extract critical strings of data, thereby offering an opportunity to leverage unstructured data. It has been already in use in various healthcare operations across the world. The market for NLP in healthcare and life sciences is expected to reach $2650.2 million by 2021 [44]. The major drivers of NLP applications in healthcare [40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69] include the following:
the rising need for handling the surge in clinical data;
support for value-based care and population health management;
improving clinical documentation and making computer-assisted coding more efficient;
improving patient and healthcare provider interactions;
empowering patients with health literacy;
increasing need for higher quality healthcare.
So far, the applications of NLP in healthcare have achieved remarkable results, as a result of which its deployment in healthcare technologies has been increasing in recent years. For instance, NLP techniques were used for reviewing more than 2 billion EHR documents for indications of PTSD, depression and potential self-harm in veteran patients, in 2013, by the Department of Veterans Affairs (USA) [45]. Similarly, in another study [46], an analytics algorithm that leverages NLP was able to predict the onset of psychosis in high-risk youths with 100% accuracy. Similarly, a study conducted by researchers from the University of Alabama found that by applying NLP techniques the reportable cancer cases identified was 22.6% more accurate than a manual review of medical records [47]. Further, various other studies have identified the potential benefits, including effective decision-making by physicians; reducing physician burnout (disillusionment among doctors tired of repetitive data entry tasks and administrative duties as well as excessive time spent combing through patient data); addressing accelerating demand for healthcare services; and dealing with increasing numbers of healthcare claims [48, 49, 50, 51], through the application of NLP techniques in the healthcare context.
NLP can enhance education technology in various ways, in particular, being effective in analysing data and text, thereby delivering meaningful outcomes. For learning of language-related subjects, it can enhance teaching by focusing on reading, writing and speaking. In general, it can support the needs of students, teachers and researchers [40, 41, 42, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71]. Language assessment (formative and summative) is one of the upcoming major areas of NLP application, being used for assessing student’s proficiency in reading, writing and speaking (e.g., automated scoring system for assessing/grading essays using NLP techniques). Syntactics analysis, for instance, can be used for correcting writing errors, which can provide instant feedback for correction and this process can be very useful for students, especially with the disabled, such as the deaf/ blind [41]. Other areas of application include proofreading, detecting errors of machine translation, assessing the meaning and content of student works, such as essays, short/long answers, training non-native speakers, and assessing reading and speaking [42, 52, 53, 54, 55].
Moreover, NLP can be used in the teaching the use of language, that is, any subject using any language as a medium. One of its current uses pertains to the chatbot/virtual assistant applications that are used for various purposes, including teaching, training, tutoring and assessment in the education sector. Chatbots can also be integrated with gaming technologies, which promotes an active learner environment in the E-Learning context, with virtual characters or avatars [56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71]. The chatbot application, similar to E-Learning resources, also fosters students’ engagement in learning activities by motivating them and gaining their attention by using innovative media features [57]. They can also be used in self-guided learning through learning modes, such as quizzes, which is one of the important principles of E-Learning [58]. However, many extant E-Learning approaches (online educational videos, online classes, portals) have been focused on one-way communication using rich and real-time media, thus failing to address pedagogical and social aspects. With the introduction of discussion forums and messaging applications, this issue was addressed to an extent, but increased the complexity and the amount of information to be processed, which can be a burden to the learner [59]. Chatbots in such instances can be very effective in providing the accurate information in real time, where the learners need not depend on different entities to seek answers. The personalisation and additivity features can be integrated into the chatbot applications, which can increase the accuracy of the learner model obtained by the student. He/she can negotiate jointly with the model using a natural conversational flow of interaction [59]. This aspect reflects the difference in designing educational chatbot applications and E-Learning resources. That is, for the former, voice user interface and conversational flow techniques need to be designed closely with the users of the system, this allows for the inclusion of culture and social issues in the stages of design, unlike E-Learning where the developers greatly influence the design process [70].
In addition to assessing students’ linguistic inputs, through such matters as feedback, assessments/ coursework, essays, short/long answers and serving as a medium of instruction (tutoring, teaching, training), NLP can also be used in processing text and speech in other ways that can support teachers, students, system developers and researchers. As the amount of electronically available text in education is increasing rapidly, NLP can be effective in organising the relevant text for teaching. For, it can be a very onerous task for teachers to identify appropriate materials for effective input during lectures. That is, teaching with the most up to date course materials is beneficial for both students in learning and teachers in teaching the subjects more effectively and efficiently [41]. In addition, NLP can be effective in research, especially in formulating meaningful extractions from bodies of literature (systematic reviews, scoping reviews, meta-analyses etc.). In addition, NLP can be effective in processing qualitative data, such as those collected from interviews, in various formats including audio, video and text. Moreover, it can be used for converting audio translations from one language to other or into text, thereby assisting with data analysis [60, 61].
Sectors such as hospitality and travel, manufacturing and logistics, media and entertainment etc. can benefit from the application of NLP. For instance, the service engineers who repair electronics and other products at homes and offices need to provide the fault reports to the companies, which will be analysed and the identified issues would be resolved in products manufactured in future. However, compiling and interpreting information provided by the service engineers (age of devices, parts replaced, fault description etc.) could be a complex task for quality engineers as the text can be full of abbreviations, spelling mistakes and can range from verbose to abrupt in content length [72]. NLP can effectively refine such data and provide appropriate information for quality engineers. NLP can be implemented in all those areas where AI is applicable either by simplifying communication process or by refining and analysing information. Similarly, it is applied in hospitality and travel industry in providing excellent customer satisfaction through chatbots and virtual assistants in selecting hotels, booking flights, providing information about places to visit and experience etc., which is customised according to the travellers’ preferences [73]. Similar applications of NLP can be identified across all the sectors where the services are provided to the customers, such as streamlining the programs according to the customers’ viewing history on televisions (Media & entertainment) [74]; or communicating with travel chatbots about the travel routes while driving such as Google Maps(travel). Therefore, NLP can be applied across various sectors which are not only service oriented but also manufacturing sectors.
NLP has made a major leap in the past few years, both in theory and practical integration into various industry solutions. Interacting with a virtual chatbot when booking a hotel or flight to extracting insights from call-centre interactions to analyse customer behaviour, such as their attitudes and satisfaction levels, has made NLP’s presence felt in almost every industry-based solution. With deep learning being progressively developed, it has finally come into its own with RNN, outperforming the traditional ML methods in a wide range of NLP tasks. It can deliver better performance than humans in complex tasks such as questioning-answering and machine translation [62]. In addition, the recent advances in the technology and practices are promising for improving scalability and robustness. That is, they herald a shift in how business organisations consume computing resources and deploy NLP applications. From the technical perspective, various new approaches have been emerging for such learning (NLP and deep learning using training data), such as the Universal Language Model Fine-tuning (ULMFit); and Bidirectional Encoder Representations from Transformers (BERT), developed by Google for contextual pre-training, which has now advanced to XLNet. This avoids the issues that BERT suffers from by using a technique called ‘permutation language modelling’ [63]. These methods have improved NLP tasks, outperforming state-of-the-art performance as well as obtaining high accuracy. For example, application of the ULMFit method on text classification tasks has reduced the error by 18–24% for the majority of datasets. In addition, with only 100 labelled examples, it matched the performance of training from scratch on a hundred times more data [62].
The market for NLP in future is considered to be very promising, for various reports [30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64] have projected a rapid increase in its application. The NLP market, including hardware, applications and service is projected to reach $22.3 billion by 2025, while the market for AI enabled NLP software has been forecast to reach $5.4 billion by 2025 [64]. With the integration of deep learning techniques and NLP, with platforms like iDS Cloud, businesses in future will reap benefits in the areas of customer services, marketing, business intelligence and operational management. This will reduce the dependency on the data scientists, thereby reducing the costs and improving process efficiency [65]. Humanoids/robotics is one of the most promising advancements in technology, which can be experienced in near future in industrial sectors and also in social lives for managing various tasks. However, enabling humanoids to function like humans in every aspect and assisting them in performing most complex activities would need the ability to comprehend entirely accurately human speech. Given the versatile nature of robots, NLP will become more important than ever, because a single misinterpreted command by one could lead to it performing undesirable actions and may even cause harm to humans. Research on designing socially intelligent robots by using NLP [66, 67] has been increasing in recent years, which could result in the development of fully functional and safe humanoids in the near future.
The purpose of this paper is to review the applications of NLP in business. NLP potential lies in effectively learning and understanding the natural language. It can handle the issues associated with translation and transliteration by effectively improving the communication process between humans and machines across various formats. Based on the review, it can be concluded that its presence in various industry-based solutions has been increasing in the recent years. Complex processes in commerce, such as predictions and decision-making in stock-market trading; simplifying customer interactions using chatbots on commerce platforms, thus making the interaction more enjoyable; analysing citizens issues from large volumes of data in E-governance; effectively managing healthcare operations, such as diagnoses, service delivery and records management; and improving the learning and teaching approaches in education sector, are some of the benefits that NLP techniques can engender. In addition, NLP’s integration with advanced technologies, such as ML, AI and deep learning, can deliver more accurate outcomes compared to the use of traditional methods. However, its application in the areas of AI, robotics, and other advanced systems is under-researched. In sum, given the efficiency of NLP techniques in improving the accuracy in data analysis and processing of natural language, it has immense scope for use in the areas of robotics and business intelligence in future.
Epigenetic factors and changes in the population’s lifestyle are some of the factors that have contributed to the increase in IgE-mediated allergies worldwide. Data from the World Health Organization reveal that about 30% of the world population suffers from allergies in all age groups. Due to this increase and the effect that allergic diseases have on people’s quality of life, a treatment, or even a cure, has been a priority among researchers, doctors, and society [1, 2]. Allergic reaction episodes are usually controlled with medication; however, the only treatment that acts on the immunological cause of the disease is allergen-specific immunotherapy (AIT) [2]. AIT is used to treat various forms of allergic diseases involving type I hypersensitivity, as it can modify TH2-driven immune responses by reducing symptoms after exposure to the allergen [3, 4].
Upon receiving a dose of immunotherapy containing the allergen, a shift from the allergenic TH2 inflammatory profile to the TH1 inflammatory profile and the generation of regulatory immune cells occurs. Decreased levels of mast cells, basophils, and eosinophils are seen in the mucosa and an increase in the production of allergen-specific regulatory T and B cells (Treg/Breg) occurs [5].
The generation of regulatory T cells (Treg) is the key event for the development of immune tolerance. Immune tolerance occurs in a peripheral and specific way, where the first is initiated by the secretion of IL-10 and TGF-β by allergen-specific Treg cells during continuous exposure and the second is associated with the increase in cells that present CD3+, CD25+ markers, and FOXP3+ in the nasal mucosa [6].
Essential features of AIT suggest that it has many advantages for the treatment of allergy because it works on a specific type of allergen and thus leads the individual’s immune system to establish an immune response against the one who caused the disease [7, 8]. Furthermore, allergy vaccines can be produced relatively quickly and inexpensively compared to treatments with biological agents. Another advantage is that, unlike treatments with an anti-inflammatory profile, AIT can stop the progression of both mild allergy (rhinitis) and more severe forms such as asthma, modifying the natural course of the disease [9, 10, 11]. However, some aspects need to be considered for the success of immunotherapy. The first is that AIT is in the group of precision medicine treatments, where the allergens causing the disease need to be identified so that the correct vaccine is administered. The second aspect is the need to produce effective and safe vaccines against different allergens to be co-administered, thus causing polysensitization. Furthermore, thirdly, the administration of AIT can cause side effects in patients [12, 13].
Molecular allergy diagnostics (MA) is currently the most helpful patient selection method for prescribing allergen-specific immunotherapy (AIT). Component-resolved diagnosis (CRD) was established in 1980 as a new concept in allergy diagnosis. The CRD identifies a specific IgE toward natural or recombinant allergens rather than raw allergen extracts to determine a patient’s sensitization at the molecular level [14]. More than 130 allergen molecules are commercialized. For more precise identification of the allergen, assays such as singleplex-ImmunoCAP, ImmuLite, and HyTech or many allergens per sample depot in microarrays (multiplex platform-ImmunoCAP ISAC-ThermoFisher Scientific/Phadia) can be employed [15, 16]. On the other hand, allergy Immunoproteomics can be an excellent ally for identifying unknown allergens. Proteomics has become critical to identify and structurally characterize allergens, including in vitro diagnostics, allergen discovery, and the analysis of biologicals proposed for AIT [11, 17].
Concerns about patient safety and treatment efficacy are the main reasons for the search for new approaches to AIT, so we have brought together several strategies that have been proposed to improve the effectiveness and safety of immunotherapies.
The first to work with allergen-specific immunotherapy (AIT) was Noon [18], injecting grass pollen extracts into allergic patients. In this study, Noon was able to observe a reduction in symptoms and greater allergen tolerance for almost 1 year. Later, in 1935, Cooke and his team [19], after successful clinical trials, demonstrated that AIT induces allergen protection through specific IgG antibodies that can suppress allergen-induced skin inflammation.
Allergen-specific immunotherapies (AIT) use allergen extracts obtained from natural sources. Characteristically, the active products in AIT are a combination of allergens with other proteins extracted from biological sources (egg, pollen, and mites), used without alteration or treated with aldehydes, and then formulated with or without an adjuvant [5]. The new proposals to produce AIT rely on recombinant, synthetic proteins, or DNA, instead of using natural extracts of allergens in their formulation. After identifying the genomic sequence of interest or the allergen itself, these are extensively tested through in vitro assays and animal models to obtain information about their allergenicity and immunogenicity [20].
The molecular era of AIT employs native recombinants, hypoallergenic recombinants, peptides containing short, and nonreactive IgE T-cell epitopes, followed by hypoallergenic recombinant peptides, as AITs needed to improve immediately in two aspects: specificity and safety [21].
A summary of each of the molecular approaches currently used for AIT will be presented below.
The use of native recombinants offers advantages over natural allergen extracts as they are well defined and contain relevant epitopes. Although, native recombinants cause immediate and late-phase side effects like natural allergens because of preserved IgE reactivity and T-cell epitopes. Thus, the preparation of AIT with these recombinants requires the maintenance of dosing schedules and multiple maintenance injections. However, the high quality of the vaccine (low cost and reproducibility) is the main advantage over natural extracts [22].
After producing the first recombinant allergens, it was demonstrated through in vitro experiments that the characteristics and the high proportion of epitopes resembled the allergen extracts [23]. Two other critical AIT studies also demonstrate this: in the survey by Jutel et al. [24], a mixture of 5 recombinant grass pollen demonstrated that a recombinant allergen vaccine can be an effective and safe treatment to improve the symptoms of allergic rhinitis. Clinical benefit is associated with modification of the specific immune response with IgG4 production and reduction of IgE antibodies consistent with the induction of IL-10-producing regulatory T cells. And the study by Pauli et al. [25] showed the efficacy of an AIT with native recombinants for the treatment of birch allergic rhinoconjunctivitis, concluding that the vaccine was safe and effective in the treatment of birch pollen allergy and induced a highly specific immune response.
Recombinant hypoallergenic derivatives are characterized by having a reduced reactivity to IgE. Several techniques have been developed to reduce IgE reactivity, including fragmentation, oligomerization, mutation, and sequence reassembly [26]. Hypoallergens do not cause immediate side effects. However, after immunization, they induce specific IgG antibodies. Allergen-specific T-cell epitopes remain preserved in these molecules and may lead to late-phase T-cell mediated side effects [21].
In this sense, a clinical study with patients not allergic to birch pollen was carried out for 2 years. Three injections were administered subcutaneously with a monthly interval of a vaccine containing hypoallergenic recombinants obtained from the mentioned allergen. Vaccine administration also took place before the period of the first birch pollen season, with a booster dose later given before the next birch pollen season, thus allowing better monitoring of vaccination in the face of seasonal exposure to the allergen. It was observed that most patients immunized with the hypoallergenic recombinant vaccine induced levels of IgG antibodies against the allergen Bet v 1, which suggests that these antibodies act by blocking the IgE interaction with the allergen Bet v 1 [27].
Another model of recombinant hypoallergens is peptides containing transporter-linked B cell epitopes, where the presence of allergen-specific T cell epitopes is reduced to decrease allergen activity further, thus increasing safety. The use of carrier molecules on these peptides facilitates their production and increases their immunogenicity and ability to induce blocking IgG antibody responses [21, 28].
A complement to hypoallergenic recombinants is the construction of peptides containing B cell epitopes linked to a transporter [28]. Vaccines containing B cell epitopes are composed of small peptides that cannot react with IgE, being obtained from allergens, specifically from the sites where the interaction with this antibody occurs. With the transporter, they offer patients a good IgG response that works by blocking the binding of the allergen to IgE [8].
These vaccines are produced from the fusion of recombinant proteins by expression in a bacterial system, using
BM32 is a B-cell epitope-based vaccine built to treat grass pollen allergy that has already been evaluated in several clinical trials and is the most advanced vaccine [30].
An important allergen from peanuts is Ara h 2. A fusion protein of the S-layer protein, SIpB from
A study was carried out with Der p 1, a potent mite allergen responsible for causing respiratory allergies, for obtaining a fusion protein of a tetanus toxoid molecule with two copies of a peptide with hypoallergenic characteristics, previously identified through bioinformatics tools. After getting the protein DpTTDp, mice were immunized to assess the allergenic potential and production of IgG antibodies. It was observed in this study that the protein DpTTDp induced relevant levels of IgG antibodies, which act by inhibiting the interaction with IgE of patients allergic to mites, making it a candidate for a vaccine based on B cell epitope for the treatment of allergies to mites [32].
Another similar study was carried out with Salsola kali pollen, an allergen that triggers allergic rhinitis in dry and desert areas worldwide. A hypoallergenic vaccine based on B-cell epitopes was designed and called Sal k 1-KLH, composed of a peptide derived from the allergen Sal k 1 conjugated to the keyhole limpet hemocyanin transporter molecule. This study showed that the vaccine produced high IgG levels in immunized mice that block IgE interaction but did not show a T cell lymphocyte response compared to the extract and the recombinant [33].
Peptide-based immunotherapy (PIP) has been considered a safe strategy for epitope-based vaccines. Peptides must contain T cell epitopes. Peptides cannot bind IgE but bind to major histocompatibility complexes. Successful trials involve Japanese cedar pollen, grass pollens, ragweed, cat allergen Fel d 1 [34], honeybee venom, and house dust mite [35]. The role of innate immune cells in allergen immunotherapy that confers immune tolerance to the sensitizing allergen is unclear. The efficacy of immunotherapy is underscored by the induction of tolerance (T helper cell type 2 anergy Treg cell upregulation of immune deviation) and modification of innate and adaptive immune responses. It is speculated that they can induce. [36].
Through epitope mapping studies, it is possible to identify which protein sequence is related to the induction of immunological tolerance and which does not participate in the inflammatory process triggered by the allergen. This is because peptides based on allergen epitopes have essential characteristics used in the clinical field to bind to a variety of class II HLA molecules [37].
An in silico study was carried out with the aeroallergen Zea M 1, a corn pollen allergen responsible for causing allergic reactions. The study aimed to evaluate the epitopes that had the potential to compose a vaccine based on the combination of B and T cell epitopes. After identifying B and T cell epitopes through prediction analyses, it was observed that the T cell epitope (AEWKPMPSW) presented an ideal and stable fit to the binding groove of the MHC I complex from B cells. The epitope KVPPPGPNITTNY remained conserved among homologous allergens and showed more significant potential for the vaccine [38]. The vaccine strategy based on T-cell epitopes is also being investigated for food allergies. First, the peptides were synthesized, and the T cell epitopes were mapped through assays of the proliferation of T cell responses in allergen-sensitized mice. Subsequently, the animals were treated with synthetic peptides and evaluated for antibody and cytokine levels. It was found in animals a reduction in symptoms and levels of cytokines and antibodies manifested in the allergic process, as well as a shift in response to a Th1 pattern and the production of IgG2a antibodies, which are characterized as adequate immunotherapy to treat allergy to shrimp [36, 39].
Vaccines proposed a 100 years ago, and still used today, employ crude extracts and attenuated viruses. After identification of the allergens structures, AIT began to use recombinant proteins and epitope-peptides. However, highly refined antigens and derived peptides present low immunogenicity and often lead to the stimulation of weak and short-lived immunity, not activating all facets of the immune response, requiring adjustment of new immunostimulatory adjuvants to enhance immune responses induced by poorly immunogenic antigens. There are only a few adjuvants approved for human use. Alum, various aluminum salts, and the first and most commonly used adjuvant were the only human vaccine adjuvant for more than nine decades until 2009 [40]. Alum is not compatible with mucosal vaccines and is unsuitable for aluminum intolerant individuals. In 2009, the Food and Drug Administration (FDA) approved AS04, a combination of alum and monophosphoryl lipid A (MPLA), for human use [41]. From 2016 to 2018, the FDA approved three more adjuvants (i.e., MF59/AS03, CpG 1018, and AS01b). The first, MF59/AS03 is a squalene-based oil-in-water emulsion used in influenza vaccines [42]. The adjuvant CpG 1018 is a short synthetic oligonucleotide, agonist of TLR9 that is being used in a vaccine against hepatitis B. moreover, AS01b is a combined adjuvant containing MPLA and saponin QS-21 in a liposomal formulation that induces strong humoral immune responses and cellular and has been approved by the FDA for use in Shingrix® against herpes zoster and by the European Medicines Agency (EMA) for use in Mosquirix® against malaria [40].
Studies have found that CpG oligodeoxynucleotides are helpful as adjuvants in inducing Th1-type immune responses, demonstrating their immunomodulatory activity in a murine model of asthma, as they improve the function of antigen-presenting cells and increase the generation of vaccine-specific humoral and cellular immune responses [43]. Based on this technology, a randomized, double-blind, placebo-controlled, phase 2 trial of a vaccine based on ragweed pollen antigen (Amb 1), conjugated to an immunostimulatory DNA phosphorothioate oligodeoxyribonucleotide (AIC), was done in 25 adults allergic to the pollen of this plant. In this work, the vaccine (with a regimen of 6 weeks) offered long-term clinical efficacy in treating ragweed allergic rhinitis [44].
A powerful strategy for safe development of AIT is the covalent conjugation of allergens to toll-like receptor (TLR) agonists. Méndez et al. [45], synthesized two families of ligands, an 8-oxoadenine derivative as a ligand for TLR7 and a pyrimido[5,4-b]indole as a ligand for TLR4, both conjugated to a T-cell peptide from Pru p 3, one of major allergen from Prunus persica (Peach). These conjugates interacted with dendritic cells, inducing their specific maturation, T cell proliferation, and cytokine production in peach-allergic patients. In addition, they increased the frequencies of Treg cells in these patients and could induce IL-10 production [45].
The construction of allergens coupled to virus-like particles (VLPs) started from a similar principle to that described for allergens coupled to immunomodulatory sequences. In this technique, the allergen molecules are chemically coupled or specific binding systems to virus-like particles through recombinant expression [46]. This technology has shown reduced allergenic activity in vaccines and good immunogenicity. The impediment to its use, on the other hand, is the difficulty in producing the vaccines in a replicable way due to the uncontrollable coupling process [21]. A sophisticated approach to engineering virus-like nanoparticles (VNPs) has been demonstrated by Kueng et al. [47],. This work showed that the cDNA encoding the allergen was coupled to the DNA encoding the virus.
In a preclinical trial of allergy to mugwort pollen (also known as a queen of grass, field chamomile, or fireweed), these particles were used successfully for prophylactic vaccination [48]. Virus-like particles (VLPs) are safe platforms for inducing protective antibodies, and several VLP-based vaccines are commercially available, including cat allergens. In a previous study, a vaccine composed of Qβ-derived VLPs coupled to the cat allergen Fel d 1 was highly immunogenic and capable of inducing IgG antibodies in mice. Immunization of Fel d 1 sensitized mice with protected Qβ-Fel d 1 against anaphylaxis after challenge with Fel d 1 allergen [49]. A recent study showed that the allergens displayed in Qβ-VLP are immunogenic but not reactogenic and do not activate human mast cells. VLP could constitute a platform to deliver allergens to allergic patients immunogenically and effectively but safely. [50] tested peanut allergy vaccine candidates based on the immunologically optimized VLP derived from cucumber mosaic virus (CuMVtt). They demonstrated that the inactivated, VLP-coupled allergen reduced systemic and local allergic symptoms after challenge with the whole allergen extract (composed of about 12 allergenic proteins), demonstrating that immunization against a single allergen protected against a mixture of allergens could be a hope for patients allergic to many components of an extract from a single source [50].
Publications from three decades ago showed that nucleic acid constructs (plasmid DNA or mRNA) could be injected into mice, resulting in the encoded protein made in situ. An initial study demonstrated that plasmid DNA encoding virus antigens could result in the generation of immune responses, so efforts were directed toward the use of plasmid DNA in vaccines [51].
Nucleotide vaccines are vectors that encode antigens and retain adjuvant-like activity by stimulating innate immune responses that contribute to adaptive responses [52]. Some questions were raised on whether a DNA vaccine could initiate an autoimmune disease since anti-DNA antibodies are a hallmark of autoimmune diseases. The results demonstrate that there is safety in using these vaccines and that this incorporation does not occur [51].
DNA vaccination presents the ability to rapidly induce strong CD4 and CD8 T cell and antibody responses. Several animal models for allergic diseases have demonstrated that DNA vaccination can induce a Th1 type immune response, which could counterbalance the Th2 response. Immunomic Therapeutics, Inc.’s research group developed novel allergy immunotherapy based on LAMP technology to treat pollen-induced allergies. Lysosomal Associated Membrane Protein 1 (LAMP-1 or LAMP) is a lysosomal residential protein. It has been shown that the inclusion of LAMP in the DNA plasmids significantly enhanced both cellular and humoral responses in vaccinated animals. The LAMP-Vax platform utilizes an up-to-date targeting approach, which should avoid therapy-induced side effects caused by high amounts of free allergen. Alternatively, the synthesized allergen-LAMP fusion protein is directly shuttled into the lysosomal compartment, circumventing the patient’s exposure to the native allergen. Instead of inducing tolerance, this therapy is designed to reverse the allergenic IgE/TH2 response toward an IgG/TH1 response [53].
Cry j 1 and Cry j 2 proteins are the 2 major allergenic components in Japanese red cedar (JRC) pollen and cause pollinosis (JCP) in 30–35% of the Japanese population. Su et al. [54] demonstrated that DNA plasmids encoding LAMP fused with Cry j 1 and Cry j 2 proteins elicited a strong Th1 response in mice. After repeated allergen exposure, vaccinated mice were well protected, as indicated by a minimal level of allergen-specific IgE production. The safety and immunological effects of an investigational DNA vaccine encoding CryJ2-LAMP were evaluated by Phase IA and IB clinical trials. Results indicated that CryJ2-LAMP DNA vaccine is safe and has the potential therapeutic potential for JRC and/or Mountain Cedar (MC) sensitive subjects.
Studies in Phase 1 trials to evaluate the safety, tolerability, and immune response in adolescents or adults allergic to peanut allergens employing multivalent peanut-LAMP-1 DNA vaccine, including Ara h 1, Ara h 2, and Ara h 3, are promising [55].
To obtain vaccines defined for passive immunization, specific blocking antibodies for human allergens are necessary. The first published studies where these allergen-specific antibodies were reported appeared more than two decades ago [21]. A combinatorial library to obtain IgE was constructed from peripheral blood mononuclear cells of an allergic patient to grass pollen where, for the first time, the Fabs regions of IgE specific for human allergens were isolated [56]. An IgE Fab specific for the major grass pollen allergen (Phl p 2) was converted into recombinant human IgG, and this blocked the Phl p 2 induced basophil degranulation, thus demonstrating its therapeutic potential [57].
Bi-specific antibodies were created so that an IgG-specific recombinant allergen could block the entry of allergens through the respiratory epithelium. It was possible to demonstrate the immobilization of allergen-specific IgG blocking antibodies using IgG specific for ICAM1 in respiratory epithelial cells, thus preventing the entry of allergens and opening up possibilities for topical treatment using blocking antibodies [58]. The idea of passive immunization from allergen-specific recombinant IgG antibodies is exciting and is undoubtedly a possible approach for allergen sources that contain mainly a significant allergen that can be blocked with one or a few monoclonal antibodies. This approach will be beneficial for seasonal allergies, as a pre-seasonal immunization can effectively protect the patient during seasonal exposure to the allergen [21].
This technology for formulating a safer immunotherapy is based on the classic studies of hematopoietic stem cell transfer from one mouse strain to another strain with different MHC origins early in life [21]. From that study, Baranyi et al., [59] demonstrated that rats received such cells that express the allergen could not be sensitized against the corresponding allergen. Furthermore, even using a sensitization protocol with aluminum hydroxide adsorbed allergens, it was not possible to induce allergen-specific T cells, antibodies (of any isotype, including IgE), or allergic immune responses, indicating that a robust lifetime tolerance was achieved, which depend on mechanisms of central tolerance rather than peripheral regulation.
This technique has an immunomodulatory treatment, uses a protocol for cell transduction − which can be dangerous − and needs to be applied early in life, probably immediately after birth. However, a cell-based treatment shows that a robust, lifelong, allergen-specific immune tolerance is achievable [21].
The cell-based allergen-specific prevention approach is highly experimental, warranting further investigation in clinical trials, as major safety hurdles can be overcome [21].
Other approaches are being sought to try to reduce the risks of side effects and have a safer AIT and with that alternative routes of administration have been studied.
Subcutaneous immunotherapy (SCIT) is the route of administration with the most well-established underlying mechanisms and has been in use since 1911. Already the Sublingual immunotherapy (SLIT) has been considered due to its ease of use and reduced side effects [21].
The appropriate candidates for AIT are mainly children with allergic asthma. The use of molecular diagnosis techniques [component-resolved diagnostics (CRD)] increases the effectiveness of AIT since it allows physicians to identify better whether children with allergic respiratory symptoms are sensitized to major allergens or cross-reactive molecules [60].
A review by Tsaburi [61] and colleagues gives us an understanding of the use of SCIT and SLIT in the treatment of children with allergic asthma. Studies have shown a significant decrease in asthma symptoms and also a preventive effect at the onset of the disease. And while SLIT safety profile appears better, some results suggest that SCIT efficacy is better with an earlier onset than SLIT in children with allergic asthma. Furthermore, there is no effective SLIT for significant allergens such as food and aeroallergens [62, 63].
Another approach to improving AIT is oral immunotherapy (OIT). This pathway has been tested primarily for allergens from food sources that are resistant to digestion, such as milk, egg, peanuts, and wheat, while not being used for other allergen sources [21].
Clinical studies show that the advantages of OIT are associated with the induction of specific IgG antibodies, which can block the IgE-allergen interaction as well as in SCIT. It was also described that oral immunotherapy induced changes in cellular immune responses, which could lead to clinical oral tolerance [64].
Intralymphatic Immunotherapy (ILIT) is a new application approach that has been developed within subcutaneous immunotherapy (SCIT). The proposal for this route of administration is the large amount of immune system cells that lymph nodes present, and a direct exposure of the allergen to these cells will induce a protective IgG response and faster immunomodulation [65].
A recent review by Senti et al. [66] provides an excellent overview about intralymphatic AIT, ultrasound-guided injection of allergen extracts into lymph nodes. However, there are no studies comparing the immunological and clinical responses of ILIT and SCIT using vaccines of the same allergen, making it difficult to confirm whether intralymphatic immunotherapy induces faster and stronger responses than subcutaneous.
ILIT has an acceptable safety profile, but its disadvantage is the need to use an ultrasound device for vaccine application in lymph nodes. Furthermore, few studies have been carried out so far when compared to other routes [67].
Epicutaneous immunotherapy (EPIT) assumed that applying allergens through the non-vascularized epidermis would induce fewer systemic side effects [21].
Another critical point is that EPIT does not use a needle, being considered especially suitable for children. Furthermore, this type of immunotherapy uses high doses of allergen and, despite showing some improvement in seasonal symptoms, it does not show considerable benefit in terms of local side effects when compared to subcutaneous immunotherapy (SCIT) [68].
Table 1 brings together all the proposed administration routes, showing the advantages and disadvantages that each one presents.
Routes for administration | Advantages | Disadvantage | References |
---|---|---|---|
SCIT—subcutaneous injection | Best mechanisms documented applicable for most allergen sources | Severe side effects rares but possible; Injection needed | [18, 61, 63] |
SLIT—sublingual application in form of drops or tablets under the tongue by self-administration | Clinical efficacy demonstrated in studies | Less effective than SCIT Mechanisms are less well defined than for SCIT cumbersome treatment with low compliance applicable / available only for few allergen sources | [61, 62] |
OIT—Oral administration and swallowing | Effective for food allergey | High rate of side effects | [64] |
ILIT—Ultrasound-guided injection into subcutaneous lymphnodes | Experimental AIT form Clinical efficacy partly shown | Ultrasound-guided injection needed Advantage over SCIT not demonstrated | [65, 66, 67] |
EPIT—epicutaneous administration on stripped skin | Experimental AIT form | Clinical efficacy not demonstrated | [68] |
Routes for administration of AIT, showing the advantages and disadvantages of each route.
Allergen-specific immunotherapy has been applied for over a 100 years. This review emphasized the fundamental importance of accurately identifying the structure of allergens and their dominant epitopes, as well as choosing adjuvants. For the market establishment or acceptance new molecular AIT preparations would be the demonstration of clear added value, e.g., shortened therapy duration and superior effectiveness or tolerability. Despite the development of new approaches to allergen-specific immunotherapy, licensing any vaccine for the clinic proved complicated. Currently, allergen-specific immunotherapy with extracts of natural allergens is the only universally approved treatment for allergic patients. Isolated treatments are made with purified allergens to avoid adverse effects caused by the allergenicity of natural extracts. The latest generation of allergy vaccines based on T-cell epitopes and B-cell epitopes linked to carriers has the potential to transform AIT as it can prevent side effects, allowing the administration of doses to induce strong allergen-specific IgG responses and provide patients with sensitized with lasting effects.
AIT, like other therapies, has advantages and disadvantages in its use, but with new technologies and molecular strategies much has been sought so that safer AIT is developed and better routes of administration are developed, revolutionizing traditional immunotherapy-based in natural allergenic strata. Since success of COVID-19 vaccine allergen DNA and mRNA vaccination has been gaining prominence.
We hope that more people will benefit from this preventive way of controlling allergic diseases.
AIT | Allergen-specific immunotherapy |
CRD | Component-resolved diagnosis |
EPIT | Epicutaneous immunotherapy |
FDA | Food and Drug Administration |
ILIT | Intralymphatic Immunotherapy |
LAMP | Lysosomal Associated Membrane Protein |
LTP | Transfer protein of lipids |
MA | Molecular allergy diagnostics |
MPLA | Monophosphoryl lipid A |
OIT | Oral immunotherapy |
PIP | Peptide-based immunotherapy |
SCIT | Subcutaneous immunotherapy |
SLIT | Sublingual immunotherapy |
TLR | Toll-like receptor |
VLPs | Virus-like particles |
In our mission to support the dissemination of knowledge, we travel throughout the world to present our publications and support our Authors and Academic Editors. We attend international symposia, conferences, workshops and book fairs as well as business meetings with science, academic and publishing professionals. Take a look at the current events.
",metaTitle:"IntechOpen events",metaDescription:"In our mission to support the dissemination of knowledge, we travel worldwide to present our publications, authors and editors at international symposia, conferences, and workshops, as well as attend business meetings with science, academia and publishing professionals. We are always happy to host our scientists in our office to discuss further collaborations. Take a look at where we’ve been, who we’ve met and where we’re going.",metaKeywords:null,canonicalURL:"/page/events",contentRaw:'[{"type":"htmlEditorComponent","content":"May 18, 2022 | 1:00 PM - 2:00 PM CEST
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03 - 12 June 2022
\\n\\nPutra World Trade Centre, Kuala Lumpur, Malaysia
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24 - 27 August 2022, Beijing, China
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19 - 23 October 2022, Frankfurt, Germany
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Guadalajara International Book Fair
\\n\\n26 November - 04 December 2022, Guadalajara, Mexico
\\n\\nIntechOpen Represented by LSR Libros Servicios y Representaciones SA de CV
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May 18, 2022 | 1:00 PM - 2:00 PM CEST
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03 - 12 June 2022
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24 - 27 August 2022, Beijing, China
\n\nIntechOpen Represented by China Publishers Services (CPS)
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19 - 23 October 2022, Frankfurt, Germany
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Guadalajara International Book Fair
\n\n26 November - 04 December 2022, Guadalajara, Mexico
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. 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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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In liver resection, I/R causes post-operative transaminasemia and liver function failure. In liver transplantation, I/R causes graft dysfunction, ranging from biochemical abnormalities to primary non-function of the transplanted organ. Ischemic preconditioning is a surgical strategy to reduce the severity of I/R and improve post-operative outcomes by prior exposure to a brief period of vascular occlusion directly to the target organ or remotely to a distant vascular bed. This chapter aims to discuss the different ischemic preconditioning strategies in both liver resection surgery and liver transplantation. In addition, we will describe the differences of such surgical strategies in both steatotic and non-steatotic livers in both preclinical experiments and clinical practice. Such information may be useful to guide the design of the effective ischemic preconditioning methods in the surgery of hepatic resections and liver transplantation.",book:{id:"7875",slug:"liver-disease-and-surgery",title:"Liver Disease and Surgery",fullTitle:"Liver Disease and Surgery"},signatures:"Maria Eugenia Cornide-Petronio, Mónica B. Jiménez-Castro, Jordi Gracia-Sancho and Carmen Peralta",authors:[{id:"74565",title:"Dr.",name:"Carmen",middleName:null,surname:"Peralta",slug:"carmen-peralta",fullName:"Carmen Peralta"},{id:"150568",title:"Dr.",name:"Mónica B.",middleName:null,surname:"Jiménez-Castro",slug:"monica-b.-jimenez-castro",fullName:"Mónica B. Jiménez-Castro"},{id:"245729",title:"Dr.",name:"Maria Eugenia",middleName:null,surname:"Cornide Petronio",slug:"maria-eugenia-cornide-petronio",fullName:"Maria Eugenia Cornide Petronio"},{id:"267094",title:"Dr.",name:"Jordi",middleName:null,surname:"Gracia-Sancho",slug:"jordi-gracia-sancho",fullName:"Jordi Gracia-Sancho"}]},{id:"28628",doi:"10.5772/30124",title:"The Post-Reperfusion Syndrome (PRS): Diagnosis, Incidence and Management",slug:"the-post-reperfusion-syndrome-prs-diagnosis-incidence-and-management",totalDownloads:3517,totalCrossrefCites:3,totalDimensionsCites:4,abstract:null,book:{id:"967",slug:"liver-transplantation-basic-issues",title:"Liver Transplantation",fullTitle:"Liver Transplantation - Basic Issues"},signatures:"Kyota Fukazawa and Ernesto A. Pretto, Jr.",authors:[{id:"126448",title:"Prof.",name:"Ernesto",middleName:null,surname:"Pretto",slug:"ernesto-pretto",fullName:"Ernesto Pretto"},{id:"174429",title:"Prof.",name:"Kyota",middleName:null,surname:"Fukazawa",slug:"kyota-fukazawa",fullName:"Kyota Fukazawa"}]}],mostDownloadedChaptersLast30Days:[{id:"42855",title:"Critical Care Issues After Major Hepatic Surgery",slug:"critical-care-issues-after-major-hepatic-surgery",totalDownloads:8935,totalCrossrefCites:2,totalDimensionsCites:2,abstract:null,book:{id:"3164",slug:"hepatic-surgery",title:"Hepatic Surgery",fullTitle:"Hepatic Surgery"},signatures:"Ashok Thorat and Wei-Chen Lee",authors:[{id:"52360",title:"Prof.",name:"Wei-Chen",middleName:null,surname:"Lee",slug:"wei-chen-lee",fullName:"Wei-Chen Lee"},{id:"157213",title:"Dr.",name:"Ashok",middleName:null,surname:"Thorat",slug:"ashok-thorat",fullName:"Ashok Thorat"}]},{id:"69426",title:"Management of Patients with Liver Transplantation in ICU",slug:"management-of-patients-with-liver-transplantation-in-icu",totalDownloads:1593,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Liver transplantation constitutes the most effective and indispensable treatment of end-stage liver disease (ESLD). Major advances in surgical techniques, anesthesiological management, postoperative care, immunosuppression, and diagnostic approach have led to increased overall survival of patients. Postoperative care poses a great challenge since detrimental occurrences that need prompt treatment may affect the graft or distant organ functionality. Adequate graft function is strongly associated with distant organ restoration and rapid patient recovery. In the ICU setting, the main focal points are hemodynamic stabilization, coagulation and electrolyte disturbances correction, respiratory support, early weaning from mechanical ventilation, and evaluation of graft functionality. It is of paramount importance to facilitate early graft recovery, recognize and promptly treat systematic complications and life-threatening sequelae, and individualize treatment protocols considering graft quality, donor’s and recipient’s health status, and potential co-morbidities. To achieve those goals, technological advancements in continuous patient monitoring, graft functionality, and its metabolic reserves must be assimilated and implemented in the ICU.",book:{id:"7875",slug:"liver-disease-and-surgery",title:"Liver Disease and Surgery",fullTitle:"Liver Disease and Surgery"},signatures:"Areti Karapanagiotou, Achillefs Pitsoulis, Maria Vasileiou and Nikolaos Voloudakis",authors:null},{id:"42584",title:"Segmental Oriented Liver Surgery",slug:"segmental-oriented-liver-surgery",totalDownloads:7560,totalCrossrefCites:0,totalDimensionsCites:1,abstract:null,book:{id:"3164",slug:"hepatic-surgery",title:"Hepatic Surgery",fullTitle:"Hepatic Surgery"},signatures:"O. Al-Jiffry Bilal and Khayat H. Samah",authors:[{id:"153686",title:"Dr.",name:"Bilal",middleName:null,surname:"Aljiffry",slug:"bilal-aljiffry",fullName:"Bilal Aljiffry"},{id:"165264",title:"Dr.",name:"Samah",middleName:null,surname:"Khayat",slug:"samah-khayat",fullName:"Samah Khayat"}]},{id:"68250",title:"Robotic Liver Surgery",slug:"robotic-liver-surgery",totalDownloads:894,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Robotic liver surgery is an evolving specialty within liver surgery. The robotic platform allows some of the limitations in both open and laparoscopic surgery to be overcome. Indeed as the technology develops there is scope for the number of robotic liver resections to increase as well as their complexity. In this chapter we discuss the current robotic platform, review the current role of robotics in liver surgery and review the available data in the literature on patient outcome.",book:{id:"7875",slug:"liver-disease-and-surgery",title:"Liver Disease and Surgery",fullTitle:"Liver Disease and Surgery"},signatures:"Ricky Harminder Bhogal, Stephanos Pericleous and Aamir Z. Khan",authors:null},{id:"42361",title:"Essential Functional Hepatic and Biliary Anatomy for the Surgeon",slug:"essential-functional-hepatic-and-biliary-anatomy-for-the-surgeon",totalDownloads:7737,totalCrossrefCites:0,totalDimensionsCites:2,abstract:null,book:{id:"3164",slug:"hepatic-surgery",title:"Hepatic Surgery",fullTitle:"Hepatic Surgery"},signatures:"Ronald S. Chamberlain",authors:[{id:"67289",title:"Prof.",name:"Ronald",middleName:null,surname:"Chamberlain",slug:"ronald-chamberlain",fullName:"Ronald Chamberlain"}]}],onlineFirstChaptersFilter:{topicId:"1145",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:20,paginationItems:[{id:"83065",title:"Interventions and Practical Approaches to Reduce the Burden of Malaria on School-Aged Children",doi:"10.5772/intechopen.106469",signatures:"Andrew Macnab",slug:"interventions-and-practical-approaches-to-reduce-the-burden-of-malaria-on-school-aged-children",totalDownloads:2,totalCrossrefCites:null,totalDimensionsCites:0,authors:[{name:"Andrew",surname:"Macnab"}],book:{title:"Malaria - Recent Advances, and New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11576.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82804",title:"Psychiatric Problems in HIV Care",doi:"10.5772/intechopen.106077",signatures:"Seggane Musisi and Noeline Nakasujja",slug:"psychiatric-problems-in-hiv-care",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82827",title:"Epidemiology and Control of Schistosomiasis",doi:"10.5772/intechopen.105170",signatures:"Célestin Kyambikwa Bisangamo",slug:"epidemiology-and-control-of-schistosomiasis",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82817",title:"Perspective Chapter: Microfluidic Technologies for On-Site Detection and Quantification of Infectious Diseases - The Experience with SARS-CoV-2/COVID-19",doi:"10.5772/intechopen.105950",signatures:"Andres Escobar and Chang-qing Xu",slug:"perspective-chapter-microfluidic-technologies-for-on-site-detection-and-quantification-of-infectious",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},overviewPagePublishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"6667",title:"Influenza",subtitle:"Therapeutics and Challenges",coverURL:"https://cdn.intechopen.com/books/images_new/6667.jpg",slug:"influenza-therapeutics-and-challenges",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Shailendra K. 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Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. 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He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}]},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",biography:"Dr. Kasenga is a graduate of Tumaini University, Kilimanjaro Christian Medical College, Moshi, Tanzania and Umeå University, Sweden. He obtained a Master’s degree in Public Health and PhD in Public Health and Epidemiology. He has a background in Clinical Medicine and has taken courses at higher diploma levels in public health from University of Transkei, Republic of South Africa, and African Medical and Research Foundation (AMREF) in Nairobi, Kenya. Dr. Kasenga worked in different places in and outside Malawi, and has held various positions, such as Licensed Medical Officer, HIV/AIDS Programme Officer, HIV/AIDS resource person in the International Department of Diakonhjemet College, Oslo, Norway. He also managed an Integrated HIV/AIDS Prevention programme for over 5 years. He is currently working as a Director for the Health Ministries Department of Malawi Union of the Seventh Day Adventist Church. Dr. Kasenga has published over 5 articles on HIV/AIDS issues focusing on Prevention of Mother to Child Transmission of HIV (PMTCT), including a book chapter on HIV testing counseling (currently in press). Dr. Kasenga is married to Grace and blessed with three children, a son and two daughters: Happy, Lettice and Sungani.",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}]}]},openForSubmissionBooks:{paginationCount:2,paginationItems:[{id:"11673",title:"Stem Cell Research",coverURL:"https://cdn.intechopen.com/books/images_new/11673.jpg",hash:"13092df328080c762dd9157be18ca38c",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 13th 2022",isOpenForSubmission:!0,editors:[{id:"203598",title:"Ph.D.",name:"Diana",surname:"Kitala",slug:"diana-kitala",fullName:"Diana Kitala"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"12215",title:"Cell Death and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/12215.jpg",hash:"dfd456a29478fccf4ebd3294137eb1e3",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 29th 2022",isOpenForSubmission:!0,editors:[{id:"59529",title:"Dr.",name:"Ke",surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:20,paginationItems:[{id:"82991",title:"Diseases of the Canine Prostate Gland",doi:"10.5772/intechopen.105835",signatures:"Sabine Schäfer-Somi",slug:"diseases-of-the-canine-prostate-gland",totalDownloads:0,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82956",title:"Potential Substitutes of Antibiotics for Swine and Poultry Production",doi:"10.5772/intechopen.106081",signatures:"Ho Trung Thong, Le Nu Anh Thu and Ho Viet Duc",slug:"potential-substitutes-of-antibiotics-for-swine-and-poultry-production",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"82905",title:"A Review of Application Strategies and Efficacy of Probiotics in Pet Food",doi:"10.5772/intechopen.105829",signatures:"Heather Acuff and Charles G. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",fullName:"Reda R. Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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