Carlos Fernandez

By Lakshmanan Rajendran, Mohan Chitra Devi, Carlos Fernandez and Qiuming Peng

A deep and analytical understanding of the enzyme kinetics has attracted a great attention of scientists from biology, medicine, chemistry, and pharmacy. Mathematical models of enzyme kinetics offer several advances for this deep and analytical understanding due to their in compensable potential in predicting kinetic processes and anticipating appropriate interventions when required. This chapter concerns mathematical modeling analysis and simulation of enzyme kinetics. Experimental data and available knowledge on enzyme mechanics are used in constituting a mathematical model. The models are either in the form of linear or nonlinear ordinary differential equations or partial differential equations. These equations are composed of kinetic parameters such as kinetic rate constants, initial rates, and concentrations of enzymes. The nonlinear nature of enzymatic reactions and a large number of parameters have caused major issues with regard to efficient simulation of those reactions. In this work, an enzymatic system that includes Michaelis-Menten and Ping Pong kinetics is modeled in the form of differential equations. These equations are solved numerically in which the system parameters are estimated. The numerical results are compared with the results from an existing work in literature.

Part of the book: Advanced Chemical Kinetics