Plasmonic nanostructures have attracted considerable interest in biomarker sensing with the goal of rapid diagnostics and personalized nanomedicine. Surface‐enhanced Raman scattering (SERS) is a versatile technique for the characterization of the plasmonic effect of the metallic nanostructures as well as a sensitive read‐out approach for biomarkers detection. In this contribution, we will give a review on the key optical properties of plasmonic nanostructures as SERS substrate for protein biomarkers detection. As a consequence, two approaches, label‐free and SERS labels will be discussed in details for protein biomarkers sensing by using the plasmonic nanostructures as the substrate.
Part of the book: Nanoplasmonics