Anatomical malformations related to difficult airway in craniofacial syndromes.
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"1966",leadTitle:null,fullTitle:"Molecular Dynamics - Theoretical Developments and Applications in Nanotechnology and Energy",title:"Molecular Dynamics",subtitle:"Theoretical Developments and Applications in Nanotechnology and Energy",reviewType:"peer-reviewed",abstract:"Molecular Dynamics is a two-volume compendium of the ever-growing applications of molecular dynamics simulations to solve a wider range of scientific and engineering challenges. 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The incidence of difficult airway is higher in children with craniofacial syndromes than normal children, hence a thorough airway evaluation is crucial in order to anticipate difficult airway and to formulate a safe plan. Common challenges encountered upon examination of a child’s airway include an uncooperative child and the unreliability of the Mallampati scoring for prediction of the difficult airway in children [1]. Airway assessment must focus on the general clinical systematic evaluation as well as the more specific airway issues of each syndrome and other associated organs involvement. The approach should include history taking, physical examination, and diagnostic tests.
General clinical history should focus on the presence of any problem affecting the airway or the respiratory system including history of snoring or apneas, upper respiratory tract infection (URTI), croup, stridor, voice hoarseness, recurrent aspirations, asthma, parental smoking, and most importantly a history of previous difficult airway management [2].
The general airway examination must include: a baseline oxygen saturation on room air, respiratory rate, preferred body position (prone position must be red-flagged as upper airway obstruction), mouth breathing, existence of any obstruction manifested by intercostal/suprasternal retractions, oral examination of the mouth opening, teeth, tongue size and Mallampati score, shape and position of the mandible, hyo-mental distance, and neck length/mobility.
Nevertheless, the airway examination in children may be difficult to perform in detail especially with an uncooperative child, thus it may be restricted to the general observation of the face, mandible, and breathing pattern in such situations.
The most critical step in airway examination of children pertains at taking a lateral “profile” look of the mandible which could spot a micrognathia or a retracted mandible that might be masked with the frontal look.
General diagnostic tests: they are seldom required especially when further details of the airway are needed. An X-ray of the head and neck can show the place and the level of upper airway obstruction; however, a CT scan/MRI can provide further details (especially in tumors and vascular malformations of the airway). CT virtual endoscopy (VE) is an excellent tool used to obtain an anatomically similar representation of the intraluminal geography of the airway, including supraglottic, glottic, and subglottic structures without the risk of exposure to ionizing radiation. Compared to conventional 3-D reconstructions, the images obtained through virtual endoscopy create the impression of a true endoscopic image allowing for a tailored approach toward the airway management. A flexible fiberoptic endoscopy maybe required in children with airway pathology especially children with an unexplained hoarse voice, suprasternal/intercostal retractions, and chronic aspirations.
The clinical evaluation should focus on risk factors which may potentially contribute to difficult airway management including (Table 1) [3]:
An extremely short thyro-mental distance with an overbite, with micro/retrognathia such as seen in Pierre Robin sequence and Treacher-Collins syndrome;
A fixed neck such as in Klippel-Feil syndrome;
A small oral opening and large tongue such as seen in Beckwith-Wiedemann syndrome;
Obstructive sleep apnea +/− secondary pulmonary hypertension;
Stiff subcutaneous tissues as seen in Mucopolysaccharidosis (high risk of difficult ventilation);
Midface hypoplasia as seen in Apert and Crouzon syndromes;
Obstruction of the airway when in supine position and the need to continuously maintain in prone positioning;
History of a previous failed airway;
Soft tissue tumors and vascular malformations with significant obstruction of the airway.
Anatomical malformation | Syndrome |
---|---|
Overbite | Pierre Robin-Treacher Collins-Goldenhar |
Mandibular prognathism | Apert |
Small mouth | Pierre-Robin, Treacher-Collins, Goldenhar, Down’s syndrome |
Large mouth | Mucopolysaccharidosis, Beckwith-Wiedemann |
Palate (high arched) | Down, Crouzon, Apert, Pierre Robin, Treacher Collins, Mucopolysaccharidosis |
Cleft Palate | Pierre Robin, Treacher Collins, Goldenhar, Down’s, Apert, Crouzon |
Tongue abnormality (Large or Glossoptosis) | Beckwith-Wiedemann, Mucopolysaccharidosis, Pierre Robin. |
Short thyromental distance (less than 3 finger breadths used by the own child’s fingers) | Pierre Robin, Treacher Collins, Goldenhar, |
Subglottic narrowing | Down’s syndrome |
Tracheal abnormality (tortuosity) | Mucopolysaccharidosis |
Cervical spine abnormalities | Down’s syndrome, Klippel-Feil, Mucopolysaccharidosis, Goldenhar |
Anatomical malformations related to difficult airway in craniofacial syndromes.
The airway management plan of the infants and children with difficult airway has many proposed algorithms but not unified as in the American Society of Anaesthesiologists (ASA) adult difficult airway algorithm [4, 5, 6, 7]. The awake intubation is no more a popular option in pediatric intubations except for some emergency situations where the patient is in severe distress and obstruction, as it carries its own disadvantages (increase in intracranial pressure ICP and intracerebral hemorrhage ICH, gagging, uncooperative kid), hence induction of anesthesia with preservation of spontaneous breathing is the cornerstone for a safe airway management in patients with craniofacial syndromes with suspected difficult airway.
The airway provider should set a structured strategy for the management of the airway. Common practice is to have a “Plan A” as an initial approach with subsequent plan B and C in case of failure of the former.
An otolaryngologist attendance for emergency backup surgical access (Bronchoscopy/Tracheostomy) is recommended during the management of the potential difficult airway.
A secured peripheral IV line prior to induction is recommended in patients with cranio-facial anomalies.
Presence of two airway experts (pediatric anesthesiologists) during induction is advisable.
Induction using IV sedative medication: propofol infusion or boluses (also dexmedetomidine, ketamine)
Or
Inhalation induction with Sevoflurane
While patient is spontaneously breathing, a careful insertion of the laryngoscope blade may be attempted provided that the patient tolerates without bucking norcoughing.
A wide range of airway tools and techniques have been described for the intubation. However, it is crucial that the airway operator sticks with the tool that he is mostly familiar with. It is noteworthy to keep in mind that an airway tool is not a plan.
Techniques used for intubation of syndromic children with difficult airway include:
The paraglossal approach with a straight blade is a well-described technique for intubation in children with difficult airway where conventional laryngoscopy technique fails. Using this technique may allow the operator to avoid the large tongue commonly encountered in cranio-facial syndromes via inserting the laryngoscope’s straight blade through the trench between the tonsils and the base of the tongue. This technique allows a better exposure of an anterior larynx; however, it does not provide an adequate space for tube manipulation, hence it requires a high level of skills by the operator.
Intubation with direct laryngoscopy may be facilitated with gum elastic bougie or a stylet.
It is also challenging to perform F.O.B intubation in neonates who have a small airway as the field of vision in the distal lens is very narrow and might get easily obstructed whenever touching any obstacle, hence it requires a high-level skill set and expertise.
However, the removal of the LMA might get complicated with accidental ETT extubation, thus many techniques have been described for the removal; however, the safest strategy remains keeping both the LMA and the ETT in place after intubation and removing them together at extubation.
If “Cannot ventilate” through LMA, then the operator should immediately move to plan C.
If all the previous attempts fail, then an emergency surgical airway must imminently be resorted to by the otolaryngologist with either an emergent rigid bronchoscopy placement or an emergency tracheostomy.
An atraumatic intubation with minimal airway edema
A minor short surgery not involving the airway (excluding adeno-tonsillectomies)
Absence of a history of severe obstructive apnea
The extubation should be performed when the patient is fully awake with vigorous spontaneous breathing and resumption of airway reflexes. The anesthesiologist must be ready for a re-intubation with all the airway tools set up should the extubation trial fail.
Patients at risk of post-operative airway obstruction such as obstructive sleep apnea must be monitored overnight in a high dependency unit (Apnea monitoring).
Patients with significant obstructive apneas undergoing major airway surgeries (such as mandibular distraction osteogenesis surgery) in which intubation might have been difficult or traumatic should not be extubated at the end of the procedure as they are at high risk of obstruction post-op which may necessitate an intubation that would likely be extremely difficult as exacerbated by the airway edema. Such patients should be kept intubated, properly sedated, and transferred to the ICU for post-monitoring. Intravenous steroids regimen should be given to minimize airway edema.
In 1866, Dr. John Langdon Down, with few simple words, well described the main craniofacial features related to this disorder: a flat and broad face, narrow palpebral fissures, small nose, and long and thick tongue. These anomalies include a microcephaly, brachycephaly, a flattened occiput, a sloping forehead, midfacial hypoplasia, depressed nasal bridge, slanting eyes with epicanthic folds, hypotelorism, strabismus, and small ears with flat or absent helix. A cleft lip and/or palate may be present.
Collecting a detailed and accurate history from the parents is the first step in assessing the airways. Symptoms related to obstructive sleep apnea (snoring, choking, mouth breathing, sleep disturbances/restless sleep, diurnal drowsiness or fatigue) and a recent episode of upper respiratory tract infection should be noted. Any recent or active upper respiratory infection should prompt the physician to postpone any non-urgent surgery because of the high rate of postoperative respiratory complications. Examination of the oropharynx and head-neck is of utmost importance looking for any predictor of a difficult airway. A careful pulmonary examination is a must, and preoperative chest X-ray is not routinely required. An echocardiography is sometimes indicated to rule out any congenital heart defect or pulmonary hypertension [12].
The risk of upper airway obstruction at the induction of anesthesia for children with Down’s syndrome is always present, hence a difficult airway management scenario must be anticipated. A difficult mask ventilation may necessitate insertion of an oropharyngeal or a nasopharyngeal airway. Tracheal intubation in children with Down’s syndrome deserves special attention. The trachea is narrow and smaller than in healthy children, not only at the subglottic area but over its entire length and may be the site of numerous anatomical anomalies. When endotracheal intubation is indicated, a tracheal tube of 0.5 or 1 mm smaller than the expected one may be required due to the high risk of post-extubation stridor. It is recommended to monitor the ETT cuff pressure and keep it below 18 cm H2O in order to lower the risk of post-extubation stridor, whereas a smooth and non-traumatic tracheal intubation should be the rule with cuffed ETT [1].
Craniocervical instability is reported to be common in children with DS with an incidence of about 15% of the cases, mostly secondary to a hyperlaxity of the transverse ligament. Nonetheless, a malformation of the craniovertebral junction bones may be associated. Atlanto-occipital and atlanto-axial joints are at high risk of subluxation during airway manipulation which may result in compression of the underlying spinal cord [13]. Thus, a gentle and cautious manipulation of the neck and the head is required during the airway management of children with DS especially those with potential risk of cervical spine instability causing neurological deficit or at risk of worsening while under anesthesia. A cervical spine manual in-line immobilization approach must always be provided by an assistant during mask ventilation and intubation.
After surgery, a “no touch technique” awake extubation with the child kept in lateral position is preferred. Down’s syndrome children with a history of obstructive sleep apnea are hypersensitive to opioid effects and need to be admitted for post-operative apnea monitoring (with continuous SPO2 monitoring and a dedicated nurse) due to the high incidence of postoperative airway obstruction and hypoventilation. The use of non-invasive positive pressure support may be required for DS patients with severe OSA.
Pierre Robin sequence frontal (A) and lateral (B) facial [
Infants may present with airway obstruction (stridor) and respiratory distress and may require multiple surgeries (tongue adhesion, mandibular distraction osteogenesis, or tracheostomy).
The major challenge to the anesthesiologist is managing the airway of such patients who are infamous to be difficult to bag-mask-ventilate and extremely difficult to intubate.
The preoperative evaluation should focus on risk factors which may contribute to difficult airway management including:
An extremely short hyo-mental distance of less than 1 cm (or a maxillary to mandibular discrepancy of more than 1 cm)
Obstruction of the airway when in supine position and the need to continuously maintain in prone positioning
Frequent desaturations and the need to provide supplementary oxygenation
Presence of OSA (may indicate severe airway obstruction)
Presence of pulmonary hypertension
History of a previous failed airway
Co-existing pulmonary disease (secondary to reflux/recurrent aspirations, laryngo-tracheo-broncho malacia, chronic lung disease…)
Presence of reflux and feeding difficulties (nasogastric-tube dependent) [17]
The airway examination must focus on taking a lateral “profile” look of the mandible, assessing for the mandibulo-maxillary discrepancy and the degree of micrognathia. As well as examining the oral cavity for the degree of glossoptosis (size and position of the tongue) and for the presence of a co-existing “cleft palate.”
The presence of any associated syndrome (Stickler, Velocardial, Treacher-Collins) or any heart murmur upon physical exam should prompt a request of a preoperative echocardiography as congenital heart anomalies are not uncommon in such patients.
The glossoptosis and the micrognathia make the glottic opening more angled and further anteriorly displaced leading to a more anterior view with the laryngoscope. Also, the nearly absent submental space makes it impossible to accommodate the tongue during laryngoscopy which renders the view obstructed by the tongue as well as the difficulty to align the oro-pharyngo-laryngeal axes. The presence of a cleft palate may prevent proper position of the laryngoscope blade in the oro-pharynx hence further complicating the view.
Despite the subglottic anatomy is usually being normal in PRS, it should be remembered that the cricothyroid space is extremely small in infants which makes emergency crico-thyroitomy an impractical option in case of the need of an emergency airway access, thus the presence of an ENT surgeon as a backup for emergency tracheotomy is recommended as an integral part of the airway management in children with PRS.
The main aim during anesthetic induction is to preserve spontaneous ventilation by avoiding muscle relaxants as not to “burn your bridges.” This could be achieved via a careful titration of IV propofol (infusion/boluses) or through inhalation induction.
Should the scenario of “Cannot Ventilate” occur at any moment of the airway management in children with PRS, a backup plan of alternative ventilation/oxygenation techniques must be imminently applied which includes first a two-handed ventilation technique with oropharyngeal/nasopharyngeal airway, and if failed, an immediate insertion of an LMA.
In case of failure of the above techniques, a laryngoscopy attempt may be tried once as to relief the obstruction done by the tongue and resumption of spontaneous breathing, or to possibly intubate. Should it fail, a prompt decision to establish an emergent surgical airway access (tracheostomy) by the otolaryngologist must be taken immediately.
If intubation was difficult and traumatic, then extubation should not be attempted at the end of the procedure, but rather the patient should be appropriately sedated/paralyzed and transferred to the ICU for post-operative care where extubation should be delayed until the patient is fully awake and has a positive leak test, along with the appropriate set up for a re-intubation in case of airway obstruction/respiratory distress.
Apert syndrome: prominent forehead, hypertelorism, proptosis, low set ears, open mouth, and feet with extensive syndactyly [
Images of children with type 1,2,3 Pfeiffer syndrome [
Treacher Collins syndrome with characteristic facial features including downward and laterally slanting palpebral fissures, paucity of lashes and lack of naso-frontal angle, bird like appearance, micrognathia, microtia (deformed pinna), macrostomia, and large tongue [
A rigorous and warily planned algorithm is the success key in the management of the airways in children with Treacher Collins syndrome. Consultation of previous anesthesia records is of valuable aid, and a meticulous airway reassessment is required. A preoperative 3D tomographic images help assess anatomical features of the upper airway and guide the choice of the best airway management plan.
A laryngeal mask airway (LMA) is indicated for short and superficial procedures. But, whenever tracheal intubation is required, the spontaneous ventilation during anesthetic induction must be maintained until securing the airways. Fiberoptic intubation represents the preferred technique. It is facilitated by application of traction on the tongue, and a jaw thrust with a backward-upward-rightward pressure (“BURP”) maneuver. Awake fiberoptic intubation is challenging in the pediatric population owing to the lack of cooperation. Other several techniques have been successfully used for tracheal intubation, namely fiberoptic intubation through LMA, fiberoptic-assisted laryngoscopy, blind nasal intubation, retrograde intubation, Shikani Optical Stylet (SOS), indirect videolaryngoscopy with GlideScope Ranger, Airtraq optical laryngoscope, Airway Scope or C-MAC videolaryngoscope with D-Blade, and tracheostomy as the last option. The use of TruView EVO2 laryngoscope for reintubation after accidental extubation in a neonate with TCS was also reported [26, 31].
TCS patients undergoing major surgical procedures involving the airway should be kept intubated and sedated in the intensive care unit (PICU) until subsidization of the edema. For short surgical superficial procedures not involving the airway, extubation may be attempted based on the clinical judgment of the anesthesiologist and the hospital set up. Before extubation, a nasopharyngeal airway must be inserted and maintained during the postoperative period in order to prevent upper airway obstruction.
Goldenhar’s syndrome before and after surgical procedure for lip and palatoplasty, correction of macrostomia and nasal septum deformity, excision of pre-auricular tags: (A) preoperative; (B) postoperative [
The anesthetic management is risky because of the difficult airway. The degree of difficulties depends directly on the severity of craniofacial anomalies and associated vertebral defects and tends to worsen progressively with increasing age. Detecting patients at risk in the preoperative setting may anticipate challenging airway situations. Consultation of previous anesthesia records is of a valuable help; however, the airway must be reassessed before any new airway manipulation. The degree of severity of mandibular hypoplasia correlates with difficult tracheal intubation. Virtual imaging using 3D CT or cone-beam computed tomography may be indicated for selected patients to assess the airway anatomy looking for anomalies [34].
Facemask ventilation is challenging in children with Goldenhar’s syndrome due to a poor mask seal, often requiring the use of a gauze with self-adhesive tape to provide an adequate seal. The reason for this poor mask fit is the facial asymmetry and the presence of a soft tissue slit extended from the side of the mouth to the middle of the cheek on the abnormal hemi-face.
Tracheal intubation is usually more difficult to achieve than maintaining airway patency, especially in the case right-sided hemifacial microsomia. Several combined conditions may contribute to difficult intubation, including retrognathia, micrognathia, asymmetrical hypoplasia of the mandible, limited mouth opening, palatal anomalies, potentially associated vertebral defects, and limited neck motion. The hypoplastic mandible reduces the retromandibular space. The relatively bulky tongue is displaced posteriorly overhanging the larynx, thus making visualization of the vocal inlets difficult, even nearly impossible during conventional laryngoscopy.
Although fiberoptic intubation (FOB) technique is one of the popular options for securing difficult airways of patients with GS, various strategies can be adopted successfully to perform tracheal intubation; however, it is recommended that the airway operator sticks with the tool and technique that is the most familiar to his practice. These include: FOB through LMA (video-assisted fiberoptic intubation (VAFI)), GlideScope, Air-Q, Airtraq, C-MAC D-blade or C-MAC Miller-blade videolaryngoscopy, Pentax-AWS Airwayscope with tracheal introducer, Laryngeal Mask Airway helped by Pediatric Boussignac Bougie or retrograde tracheal intubation. The Truview PCD® laryngoscopy has proven its effectiveness and offers the advantage of continuously supplying oxygen via its oxygenation side port during the procedure. When the intubation is not required, LMA or nasopharyngeal airway constitutes a possible alternative [1, 35, 36].
Child with Klippel-Feil syndrome and anomaly of the Occipito-cervical junction. The images show an elevated left shoulder due to a Sprengel anomaly, a short, webbed neck, and a low hairline (scar on the thorax after surgical repair of nonrestrictive atrial septal defect) [
KPS may be related to other anomalies such as cranio-facial deformities including craniosynostosis, cleft lip, micrognathia, and laryngeal defects. Thoracic deformities such as scoliosis may be present in addition to other skeletal deformities like scapular elevation (Sprengel’s). Uro-genital malformations are commonly present as well as congenital heart defects most commonly the VSD.
Neurological deficits with hyperlaxed cervical spines and neuro-degeneration with fused spines are commonly associated with KPS [17].
Screening patients at risk for cervical spine instability is a crucial step before airway management in order to avoid spinal injury, especially those with hyperlaxed spines who may require C-spine precautions with in-line-stabilization during intubation. This is performed via a lateral neck X-ray in flexion and extension positions [1, 4, 5, 6, 7].
Obstructive sleep apnea (OSA) is not uncommonly encountered in patients with KFS, hence a preoperative sleep study may be indicated along with postoperative apnea monitor. A preoperative echocardiography must be considered especially in patients with pulmonary hypertension secondary to OSA and scoliosis.
A history of previous smooth intubation in KPS patient does not implicate a future favorable outcome due to the progressive nature of the disease. Hence, a careful preoperative assessment and planning is critical for safe airway management.
Bag-mask ventilation is likely difficult in those patients as well as direct laryngoscopy owing to the fixed neck or the in-line neck stabilization.
Should the older child be cooperative enough to sustain an awake fiberoptic intubation (with light sedation) that would be the approach of choice avoiding both the risks of difficult ventilation and neck injury secondary to airway manipulation.
Otherwise, a plan to preserve spontaneous ventilation during anesthetic induction should be performed with either total intravenous anesthesia (TIVA) or inhaled Sevoflurane (IV Dexmedetomidine and IV Ketamine can be used as well) avoiding the use of neuro-muscular blockers.
A trial of manual bag-mask to assess for ventilation is used by some practitioners before airway manipulation. The various arrays of airway tools including videoscopes (Glidescope/C-MAC etc.) as well as the fiberoptic bronchoscope have been used successfully for intubation in patients with KFS. They are preferred as first line intubation technique due to the lower incidence of cervical spine mobilization when used.
It is important to keep in mind that the option of an emergency surgical airway such as cricothyrotomy/tracheostomy is very limited in patients with KFS due to the extremely short neck, thus the airway approach must be very carefully planned.
Extubation must only be attempted when the patient is fully awake and in the presence of protective airway reflexes. An opioid-sparing anesthetic technique is recommended (regional anesthesia whenever possible) as the presence of OSA may increase narcotic-sensitivity. KFS patients should preferably be monitored in the post-operative setting in a high dependency unit or an intensive care unit according to the severity of their cardio-pulmonary and airway pathology.
If the patient is on a home BIPAP, it will be required after extubation.
Macroglossia in the patient with Beckwith-Wiedemann syndrome after intubation [
These children are associated with exomphalos, macroglossia, gigantism, macrosomia, visceromegaly, horizontal earlobe creases, renal medullary dysplasia, cardiac malformations, hypoglycemia, hypothyroidism, hyperlipidemia, polycythemia, hypercalciuria, and embryonal tumors. The presence of three features out of the above will confirm the clinical diagnosis of BWS after ruling out the clinical features of overgrowth syndromes. The risk for embryonal tumor development especially hepatoblastoma, neuroblastoma, rhabdomyosarcoma, gonadoblastoma, and adrenal carcinoma has been observed [6, 7, 17].
Preoperative assessment should include a careful evaluation of the airway focusing on the mouth opening, tongue size, and preoperative head and neck imaging if required. It should focus also on other systems involvement such as the heart, hence an echocardiography is recommended. The genito-urinary system and the liver must be evaluated in addition to the preoperative glucose homeostasis.
The major challenge during airway management of a patient with Beckwith-Wiedemann syndrome pertains to the huge tongue which might completely obstruct the airway with anesthetic induction rendering the bag-mask ventilation and intubation difficult to perform [39, 40].
Hence a careful plan A, with a backup plan B and a plan C must be organized beforehand. An intravenous line is recommended to be secured before induction. Keeping spontaneous ventilation is considered to be the safest approach to the airway that can be achieved with intravenous anesthetics or inhalational Sevoflurane and by avoiding non-depolarizing neuro-muscular blockers. Some practices may use muscle relaxants after making sure of the ability to ventilate by a trial of ventilation after induction. Sugammadex muscle (rocuronium antidote) has allowed more confidence for anesthesiologists to give muscle relaxants in order to facilitate intubation.
A variety of tools can be used for intubation ranging from the direct laryngoscopes aided by a Gum elastic Bougie or a stylet, to the Videoscopes including the C-MAC and the Glidescope, to the fiberoptic bronchoscope.
A plan B consists of inserting a laryngeal mask airway should ventilation become problematic, and in case of the latter’s failure, a plan C with a surgical airway must be immediately implemented.
Extubation must only occur when patient is fully awake and may be helped with a nasopharyngeal airway “in-situ” to help overcoming the tongue’s obstruction in the immediate post-operative period. Patients with BWS must have a post-operative monitoring after surgery in the high dependency area or the intensive care unit.
Some types of MPS (Type1: Hurler, Type 4: Morquio, and Type 6: Maroteaux-Lamy) may be associated with atlantoaxial subluxation and odontoid hypoplasia which may lead to spinal cord compression with subsequent neurological deficit. Accumulation in the cervical spines may lead to a short and fixed neck. The temporo-mandibular joint may get affected with restricted mobility. Deposition of mucopolysaccharides in the heart and vascular tissues may lead to cardiomyopathies, arrhythmias, and pulmonary hypertension [5].
A narrow/distorted trachea may prevent an appropriately sized endotracheal tube from passing throughout the vocal cords.
Fortunately, the enzymatic replacement therapy may hinder the progression of the disease, hence an adequately treated mucopolysaccharidosis patient may have a lesser risk of difficult airway than the untreated patient.
Preoperatively, the MPS patient must be well assessed for the extent of the disease as well as a focused airway assessment including the mouth opening, tongue and tonsillar size, presence of obstructive sleep apnea (which is very common in MPS), and pulmonary hypertension. A preoperative echocardiography is essential to rule out any associated cardiomyopathy. Patients with MPS type 1 (Hurler), 4 (Morquio), and 6 must be checked for any cervical spine or atlanto-axial instability [42].
Intravenous cannulation in MPS patients may be challenging due to the thick infiltrated skin, hence a preoperatively inserted intravenous line before anesthetic induction is preferable.
Spontaneous ventilation must be maintained during induction of anesthesia due to the high risk of difficult ventilation in case of apnea. This could be achieved with either intravenous or inhalational induction agents and by avoiding neuro-muscular blockers.
An LMA must be used as a second plan whenever encountering difficulties in ventilation; it can also be used to facilitate fiberoptic intubation.
Video-laryngoscopies are other favorable options for intubation in MPS patients especially those with unstable cervical spine owing to the lesser risk of neck mobilization when used. Establishment of a surgical airway access such as tracheostomy may be difficult due to the thick tissues and the associated tracheal deformities.
Vascular anomalies are disorders of abnormal vasculogenesis or lymphogenesis. They can involve any part of body and can present in any phase of development. They include different types according to histopathology and anatomical site.
VMs may be with other syndromic malformations such as Parkes-Weber, Sturge-Weber, Klippel-Trenaunay Servelle-Martorell, PHACE and LUMBAR syndromes.
Huge movable mass is found out on the left neck [
Arterio-venous malformations (AVM) involving the face and the airway are rare to occur. The main issue with airway management is the risk of massive bleeding that can occur if the AVM has been traumatized when managing the airway.
General anesthesia with an inhaled agent such as Sevoflurane or an intravenous agent (such as propofol, ketamine or dexmedetomidine) while maintaining spontaneous ventilation is the technique of choice. Video laryngoscopy, FOB-guided endotracheal intubation, and endotracheal intubation through an LMA are the most popular strategies for intubation.
A pre-procedure tracheostomy inserted under local anesthesia may be indicated for high risk malformations with severe airway obstruction [48].
The airway management of children with craniofacial abnormalities imposes great challenges owing to the difficulties in ventilation and intubation potentially encountered in most of the syndromes as well as the other systems involvement. A careful anticipation, preparation, and planning are key elements for a safe and successful airway management. The approach to each patient should be tailored according to the extent of the relevant abnormalities following a strategy of a simple clear plan A with a backup plan B and C. Preserving spontaneous breathing is one of the safe practices when patients are at risk of difficult ventilation. The use of the most familiar airway tools is pivotal in achieving favorable results. Extubation is an integral part of the airway management and should only be performed when the child meets its criteria and in a controlled environment. Post-extubation monitoring in a critical care or an observation area must be carried out for patients at risk of airway obstruction.
Special thanks for Dr. Habib El Bechouti, senior anesthesia consultant in Sidra Medicine, Qatar and Dr. Yasser Hammad, senior anesthesia consultant in Hamad Medical Corporation, Qatar for their valuable comments, chapter editing, and reviewing.
The authors declare no conflict of interest.
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:{name:"Association for Computing Machinery",country:{name:"United States of America"}}},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"426586",title:"Dr.",name:"Oladunni A.",middleName:null,surname:"Daramola",slug:"oladunni-a.-daramola",fullName:"Oladunni A. Daramola",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Technology",country:{name:"Nigeria"}}},{id:"357014",title:"Prof.",name:"Leon",middleName:null,surname:"Bobrowski",slug:"leon-bobrowski",fullName:"Leon Bobrowski",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Bialystok University of Technology",country:{name:"Poland"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"354126",title:"Dr.",name:"Setiawan",middleName:null,surname:"Hadi",slug:"setiawan-hadi",fullName:"Setiawan Hadi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Padjadjaran University",country:{name:"Indonesia"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"332603",title:"Prof.",name:"Kumar S.",middleName:null,surname:"Ray",slug:"kumar-s.-ray",fullName:"Kumar S. 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Subjects will include an overview of oral diseases and infections, systemic diseases affecting the oral cavity, prevention, diagnosis, treatment, epidemiology, as well as current clinical recommendations for the management of oral, dental, and periodontal diseases.
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Her qualifications are: a specialist in Dental Imaging and Radiology, Master in Dentistry (Periodontics) from the University of São Paulo (FORP-USP, Ribeirão Preto, SP), and Doctor (Ph.D.) in Dentistry (Stomatology Clinic) from Hospital São Lucas of the Pontifical Catholic University of Rio Grande do Sul (HSL-PUCRS, Porto Alegre, RS). She held a postdoctoral internship at the Federal University from Jequitinhonha and Mucuri Valleys (UFVJM, Diamantina, MG). She is currently a member of the Brazilian Society for Dental Research (SBPqO) and the Brazilian Society of Stomatology and Pathology (SOBEP). Dr. Marinho's experience in Dentistry mainly covers the following subjects: oral diagnosis, oral radiology; oral medicine; lesions and oral infections; oral pathology, laser therapy and epidemiological studies.",institutionString:null,institution:{name:"State University of Paraíba",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,series:{id:"3",title:"Dentistry",doi:"10.5772/intechopen.71199",issn:"2631-6218"},editorialBoard:[{id:"267724",title:"Prof.",name:"Febronia",middleName:null,surname:"Kahabuka",slug:"febronia-kahabuka",fullName:"Febronia Kahabuka",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZpJQAW/Profile_Picture_2022-06-27T12:00:42.JPG",institutionString:"Muhimbili University of Health and Allied Sciences, Tanzania",institution:{name:"Muhimbili University of Health and Allied Sciences",institutionURL:null,country:{name:"Tanzania"}}},{id:"70530",title:"Dr.",name:"Márcio",middleName:"Campos",surname:"Oliveira",slug:"marcio-oliveira",fullName:"Márcio Oliveira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRm0AQAS/Profile_Picture_2022-08-01T12:34:46.jpg",institutionString:null,institution:{name:"State University of Feira de Santana",institutionURL:null,country:{name:"Brazil"}}}]},onlineFirstChapters:{paginationCount:26,paginationItems:[{id:"83087",title:"Role of Cellular Responses in Periodontal Tissue Destruction",doi:"10.5772/intechopen.106645",signatures:"Nam Cong-Nhat Huynh",slug:"role-of-cellular-responses-in-periodontal-tissue-destruction",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Periodontology - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11566.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82654",title:"Atraumatic Restorative Treatment: More than a Minimally Invasive Approach?",doi:"10.5772/intechopen.105623",signatures:"Manal A. 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