Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
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We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\n
Throughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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The book comprises single chapters authored by various researchers and edited by an expert active in the aforementioned research area. Each chapter is complete in itself but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on modern slavery and human trafficking, and opening new possible research paths for further novel developments.",isbn:"978-1-78923-854-9",printIsbn:"978-1-78923-853-2",pdfIsbn:"978-1-83880-483-1",doi:"10.5772/intechopen.77619",price:100,priceEur:109,priceUsd:129,slug:"modern-slavery-and-human-trafficking",numberOfPages:100,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"587a0b7fb765f31cc98de33c6c07c2e0",bookSignature:"Jane Reeves",publishedDate:"January 20th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/7802.jpg",numberOfDownloads:6029,numberOfWosCitations:3,numberOfCrossrefCitations:1,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:4,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:8,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 10th 2018",dateEndSecondStepPublish:"February 19th 2019",dateEndThirdStepPublish:"April 20th 2019",dateEndFourthStepPublish:"July 9th 2019",dateEndFifthStepPublish:"September 7th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"211328",title:"Prof.",name:"Jane",middleName:null,surname:"Reeves",slug:"jane-reeves",fullName:"Jane Reeves",profilePictureURL:"https://mts.intechopen.com/storage/users/211328/images/system/211328.jpg",biography:"Jane Reeves is an Emeritus Professor in teaching-learning and innovation at the Centre for Child Protection and was one of the founding Directors of the Centre. She is a qualified social worker. As a Co-Director of CCP she worked with many stakeholders to co-write immersive simulations that tackle complex child protection issues including sexual abuse (‘Rosie 1’); neglect (‘Rosie 2’); radicalization and extremism (‘Zak’; ‘Behind Closed Doors’); paedophilia (‘Elliot’); child sexual exploitation (‘Looking out for Lottie’); and ‘Rosie goes to court’. The simulations are widely used across the UK and internationally by professionals and young people. She has led innovative projects funded by the DfE and Innovate UK and has worked on an Erasmus project with the University of Stirling, protecting children across Europe through modernising the social work curriculum. She is currently leading a global EVAC Project on online sexual exploitation and trafficking which is designing a serious digital game for children and young people in Thailand and Cambodia.",institutionString:"Kent University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Kent",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"281",title:"Sociology",slug:"sociology"}],chapters:[{id:"67334",title:"South African Perspective on Sexual Slavery, Sex Work and Exploitation",doi:"10.5772/intechopen.86720",slug:"south-african-perspective-on-sexual-slavery-sex-work-and-exploitation",totalDownloads:1916,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"After millennia, formal slavery in most jurisdictions worldwide eventually came to an end by the middle of the nineteenth century. Yet, all kinds of trapped forms of labour took its place, among others sexual slavery—one of the most serious organised crimes of our time and historically one of the oldest human practices of gender inequality and exploitation. This chapter starts with broad, introductory remarks on the possible causes of sexual slavery and exploitation as well as what we as a society can do to collectively address this pressing issue. It then looks in more detail at the extent of this problem in South Africa. The chapter then moves on to consider antihuman trafficking legislation in South Africa and what it entails; a distinction is made between sexual slavery and sex work; and the reasons, effects and value of decriminalising sex work are referred to. 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Olutola",downloadPdfUrl:"/chapter/pdf-download/70938",previewPdfUrl:"/chapter/pdf-preview/70938",authors:[{id:"277412",title:"Dr.",name:"Paul",surname:"Bello",slug:"paul-bello",fullName:"Paul Bello"},{id:"284332",title:"Prof.",name:"Adewale",surname:"Olutola",slug:"adewale-olutola",fullName:"Adewale Olutola"}],corrections:null},{id:"70042",title:"Labour Trafficking and Exploitation in Rural Andalusia",doi:"10.5772/intechopen.90090",slug:"labour-trafficking-and-exploitation-in-rural-andalusia",totalDownloads:662,totalCrossrefCites:1,totalDimensionsCites:0,hasAltmetrics:1,abstract:"This chapter presents the preliminary results of a research project, called “Research on the Vulnerability of Human Rights in Andalusian Rural Areas: Migration, Labour Treatment, and Other Forms of Exploitation for the Strengthening of Andalusian Development Agents”. In the mentioned research, we analyse the trafficking in persons for the purpose of labour exploitation (labour trafficking) and labour exploitation in the rural context of Andalusia. For this, the research focuses on three (3) provinces of Andalusia in which the fieldwork is carried out in rural areas of the provinces of Almeria, Seville and Huelva. For that purpose, this study will be structured in four sections: first, the realisation of a conceptual introduction on “labour trafficking”, its connection with contemporary forms of slavery and exposure of the factors that favour the development of this phenomenon in the Andalusian context; second, presentation of the partial data that allow us to make a localised diagnosis through the contextual approach of labour exploitation and labour trafficking in Andalusia; third, analysis of the results; and fourth, conclusions on the confrontation with the labour treatment in Spain.",signatures:"Waldimeiry Correa da Silva and Carla Cingolani",downloadPdfUrl:"/chapter/pdf-download/70042",previewPdfUrl:"/chapter/pdf-preview/70042",authors:[{id:"296029",title:"Dr.",name:"Waldimeiry",surname:"Correa Da Silva",slug:"waldimeiry-correa-da-silva",fullName:"Waldimeiry Correa Da Silva"},{id:"296030",title:"Mrs.",name:"Carla",surname:"Cingorlani",slug:"carla-cingorlani",fullName:"Carla Cingorlani"}],corrections:null},{id:"71313",title:"Slavery and Slave Codes in Overseas Empires",doi:"10.5772/intechopen.91411",slug:"slavery-and-slave-codes-in-overseas-empires",totalDownloads:756,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"The paper proposed aims to analyze the slavery legislation born between the fifteenth and nineteenth centuries, the so-called Black Codes laws—enacted in all the greatest colonial powers of the Old Continent—which regulated life and transportation of slaves in the colonies. Spain, Portugal, England and France, between the sixteenth and seventeenth centuries, created legislative codes dedicated to the slave’s management in the colonies, which regulated all aspects of their life: from religion to marriage, from cohabitation to imprisonment, from crimes to corporal punishment. Particularly widespread in the Caribbean colonies of the seventeenth century, these slave laws were soon in force in almost all American colonies of European monarchies, forming the legal basis on which the slave societies of the European empires were founded. In the wake of the Spanish, Portuguese, English and French slave codes, even states that had a marginal role in the process of overseas colonization enacted similar slave codes. It was the case, for example, of Denmark and Sweden that in the management of some of their ultramarine possessions adopted slave codes inspired by those of the greatest colonizing powers.",signatures:"Giuseppe Patisso and Fausto Ermete Carbone",downloadPdfUrl:"/chapter/pdf-download/71313",previewPdfUrl:"/chapter/pdf-preview/71313",authors:[{id:"295297",title:"Prof.",name:"Giuseppe",surname:"Patisso",slug:"giuseppe-patisso",fullName:"Giuseppe Patisso"},{id:"295300",title:"Dr.",name:"Fausto Ermete",surname:"Carbone",slug:"fausto-ermete-carbone",fullName:"Fausto Ermete Carbone"}],corrections:null},{id:"71571",title:"Traffickers: Are They Business People, Psychopaths or Both?",doi:"10.5772/intechopen.91882",slug:"traffickers-are-they-business-people-psychopaths-or-both-",totalDownloads:596,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Human trafficking has become a very contentious issue, constituting one of the most grievous human rights violations and most lucrative activities for criminal gangs and individuals. The selling and buying of human beings as a commodity has become so profitable and the industry so big that armed groups and terrorist organisations are turning to trafficking in people as a source of income to fund their organisations. Traffickers motivated by profit take advantage of vulnerable individuals, ignoring the consequences of their actions on those lives. The trafficker’s apparent lack of empathy or guilt and the ability to shut the self off from the impact of their actions is not unlike some of the noted characteristics of a psychopath. This chapter reviews published literature on trafficking and discusses whether there are psychopathic tendencies among traffickers or if they are primarily motivated by profit alone.",signatures:"Jennifer Okeke, Mel Duffy and Rosaleen McElvaney",downloadPdfUrl:"/chapter/pdf-download/71571",previewPdfUrl:"/chapter/pdf-preview/71571",authors:[{id:"295990",title:"Ph.D. Student",name:"Jennifer",surname:"Okeke",slug:"jennifer-okeke",fullName:"Jennifer Okeke"},{id:"295991",title:"Dr.",name:"Rosaleen",surname:"McElvaney",slug:"rosaleen-mcelvaney",fullName:"Rosaleen McElvaney"},{id:"318595",title:"Dr.",name:"Mel",surname:"Duffy",slug:"mel-duffy",fullName:"Mel Duffy"}],corrections:null},{id:"70093",title:"Child Trafficking: The Construction of a Social Problem",doi:"10.5772/intechopen.90118",slug:"child-trafficking-the-construction-of-a-social-problem",totalDownloads:732,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:1,abstract:"Child trafficking is a public health problem and a serious violation of human rights. 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1. Introduction
Fusion of cells occurs normally in vivo, such as of muscle cells, bone cells, macrophages, during fertilization of germ cells, and in placenta formation [1]. Somatic cell hybrid cell lines (or more simply hybrid cell lines) are cell lines that arise through intentional or nonintentional fusion of somatic cells having different origins [2]. Intra-species and inter-species (cross-species) cell fusions have been described since the 1950s [3] and can occur either spontaneously or can be mediated by human oncogenic viruses (such as Sendai virus, Epstein-Barr virus, human papilloma viruses, hepatitis B and C viruses, human T-cell lymphotropic virus type 1 (HTLV-1), herpesviruses-8/Kaposi sarcoma herpesvirus (HHV-8/KSHV)) [4, 5], polyethylene glycol [6], or electrical pulses (electrofusion) [7, 8, 9, 10, 11, 12], resulting in viable syncytial cells (giant cells or polykaryotes) with hybrid genotypes, namely heterokaryons. Mouse-human hetero-hybridoma technology has advanced significantly with the use of electrofusion technology [13]. Currently, electrically induced cell fusion is also being used to develop cancer cells with increased immunogenicity by fusion with dendritic cells for development of anti-tumor vaccines [14, 15].
Cell fusion can be important in the establishment and evolution of cell lines (e.g., [16]) and can lead to cancer progression and metastasis via genetic instability [17, 18, 19, 20]. Hybrid cell lines also can arise spontaneously. Numerous examples have been documented [21], including a case where a patient-derived xenograft model underwent spontaneous fusion with normal mouse stromal cells, forming a hybrid cell that was more tumorigenic than the parental lines [22]. Spontaneous cell-cell fusion can act as a mechanism for DNA exchange between malignant and non-malignant cells and for horizontal transmission of malignancy [21, 23]. Spontaneous cell-cell fusion can be challenging to detect. Some cases are only detected incidentally—for example, when unexpected chromosomes are detected during cytogenetic analysis [24].
Intentionally created hybrid cell lines have been used for a variety of purposes, including monoclonal antibody production by mouse × mouse and mouse × human hybridomas [25], gene mapping studies [26], studies of gene expression [27], study of cancer initiation, progression, and metastasis [21, 23, 24, 28, 29], evaluation of drug resistance mechanisms [30]; as well as in the field of virology [31, 32]. Perhaps the most commonly employed inter-species hybrid cell lines, currently, are mouse × human somatic cell hybrids. Examples of intra-species cell hybrids might include mouse × mouse (inter-strain) hybrid cells [33] or hybridomas created by fusion of mouse splenic cells and mouse myeloma cells [34].
Hybrid cell lines can be challenging to authenticate and to confirm that they are valid research models. This paper reviews historical and more recent technologies that have played a role in the authentication of inter-species and intra-species hybrid cell lines. As part of cell line authentication, the identity of a cell line is expected to be established to the species level, or if possible, to the individual donor level. There are a variety of approaches that may be used for this purpose. Over the years, these have included isoenzyme, cytogenetic, and immunological analyses, and more recently, a variety of molecular methods such as restriction length fragment polymorphism (RFLP), nested PCR analysis of mitochondrial genes, short tandem repeat (STR) profiling, single nucleotide polymorphism (SNP) profiling, sequence-based human leukocyte antigen (HLA) typing, and next generation sequencing. Each of these approaches may also be applicable to the authentication of intra-species or inter-species hybrid cell lines, although the results to be expected and, therefore, the interpretation of such results in arriving at the identification of the cell line may differ from those for non-hybrid cell lines. Inter-species hybrid cell lines have a propensity to lose chromosomes during continued passage of the cultures [18]. Such loss occurs especially in the case of hybrids of human and rodent cells, such as human × mouse or human × rat hybrids. In these cases, the human chromosomes tend to be lost with continued passage of the cultures. The results expected to be obtained with several of the authentication techniques mentioned below tend, therefore, to evolve over time as the hybrid cells are cultured [35, 36, 37, 38]. This is especially true in the case of karyotyping and total DNA content, but also may impact isoenzyme analysis and molecular-based methods.
2. Methodologies for authenticating hybrid cell lines
2.1. Isoenzyme analysis
Isoenzyme analysis was one of the first methods to be used (as early as 1970s) for determining the species-level identity of cell lines. This method is still being used [39], despite the fact that reagents for performance of the method are not commercially available. There is a considerable amount of historical data, in the public domain, for non-hybrid and hybrid cell lines, therefore, discussion of these results has relevance in deciphering hybrid cell line identities.
In isoenzyme analysis, the gel electrophoresis banding patterns and relative migration distances of intracellular enzyme isoforms are used to confirm the expected animal species of origin for test cells. Normalized migration distances obtained for the set of enzymes evaluated are compared to a set of tabular values for various animal species, and through a process of elimination, the most likely animal species of origin for the test cell is determined. Although the results of isoenzyme analysis historically have been used to confirm species-level (intra-species) identity of a cell line, the method also can be used to demonstrate the existence of an inter-species cell mixture [40] or to authenticate inter-species hybrid cell lines [27, 31, 32, 36, 37, 38, 41, 42].
When evaluating inter-species cell mixtures using isoenzyme analysis, bands migrating as expected for each of the parental species comprising the mixture are observed, provided that a sufficient percentage of cells of both species are present in the mixture [31, 38, 39, 40, 41]. In the case of inter-species hybrid cell lines, however, a variety of possible outcomes may be obtained when authenticating using isoenzyme analysis. These outcomes might include, for instance, bands for certain enzymes that migrate as expected for both parental species or for only one of the two parental species, or bands that migrate differently than expected for either parental species (Figure 1).
Figure 1.
Isoenzyme analysis of (A) lactate dehydrogenase; and (B) 6-phosphogluconate dehydrogenase in parental cells, a cell mixture, and a hybrid cell. Lane 1: parental rat-SV40 cell; lane 2: hybrid H3 (rat-SV40 × mouse 3T3 TK−); lane 3: mixture of rat-SV40 and mouse 3T3 TK−; lane 4: parental mouse 3T3 TK− (from [31]). The black lines in each lane indicate the origins (the slots in the wells into which the protein is loaded).
As is evident from Figure 1, interpretation of an isoenzyme analysis electropherogram for a hybrid cell is not as straightforward as it is for a cell mixture. The chromosomes contributed to the hybrid cell by the two parental cells determine the outcome of the isoenzyme analysis results for any given enzyme, as the genes encoding the enzymes evaluated in this method are scattered among the various chromosomes of the various animal species [37]. In fact, isoenzyme analysis was performed commonly in early gene mapping studies because linkage between genes encoding an isoenzyme and a gene of interest could be used to assign the chromosomal location for the gene of interest. Due to uncertainty of the assortment of parental chromosomes (and encoded enzyme genes) into a hybrid cell, it is not possible to predict in advance the phenotype and, therefore, the electrophoretic characteristics of enzymes being evaluated using isoenzyme analysis. This is depicted well by the results of authentication of a series of human × bovine hybrid cell lines (Table 1) by van Olphen and Mittal [32].
Authentication results for three hybrid (human × bovine) cell lines (data from [32]).
Total chromosomes includes human, bovine, and unidentified chromosomes.
Bands expected for bovine were observed, along with extra bands.
Bands expected for human were observed, along with extra bands.
Mean ± standard deviation, units are relative DNA content.
Authenticating an intentionally created hybrid cell line using isoenzyme analysis, therefore, entails evaluation of the hybrid as soon as possible after fusion of the parental cells. The migration patterns displayed by the enzymes evaluated are then considered to be the reference pattern to be expected for the hybrid cell during subsequent authentication assays. This is similar to the case for DNA fingerprinting. When reviewing historical data of cell line authentication by isoenzyme analysis, allowance must be made for loss of parental chromosomes during extended culture, as this may result in loss of electrophoretic bands associated with certain enzyme isoforms over time. Reagents for performing isoenzyme analysis are no longer commercially available, so other methods to be described below are now more commonly being used for hybrid cell authentication.
2.2. Immunostaining for surface antigens
The species-level identification of cells through use of antisera directed against species-specific cell surface markers has also been applied to the authentication of inter-species cell hybrids [32]. In the case of an inter-species cell mixture, immunostaining reagents directed against conserved surface antigens of each parental species would each be expected to demonstrate reactivity. In the case of inter-species hybrids, the result that might be obtained is not so easily predicted in advance. For instance, as shown in Table 1, the surface antigens that are actually detected in a set of hybrids may be derived from only one or the other of the parental species (Figure 2).
Figure 2.
Use of immunostaining against species-specific surface antigens to characterize parental human [293-Puro] and bovine [MDBK-Neo] cells, and three human × bovine hybrid cell lines [BHH2C, BHH3, and BHH8]. Antisera are designed α-human (anti-human), α-bovine (anti-bovine), and α-mouse (anti-mouse). The latter was used as a negative control reagent (from [32]).
It is also possible, depending upon the species-specific antisera employed and the chromosomal make-up of the hybrid cell, for an inter-species hybrid cell to display surface staining for antigens of both parental species. For instance, Kano et al. [43] reported that all human × mouse hybrids evaluated in their study displayed mouse surface antigens, while most but not all also displayed human surface antigens. Surface antigens characteristic of both parental species were displayed by all human × hamster and human × rat hybrid cells evaluated. Gallagher et al. [44] reported similar results in their analysis of the surface antigens in human [HeLa] × mouse hybrid [3T3.4E] cells. Surface antigens characteristic of both parental cells were displayed by the hybrid cells.
It is also possible that by the staining of interspecies hybrid cells, one may detect a surface antigen that is not expressed by either parental cell. For instance, van Someren et al. [41] examined a large number of human × Chinese hamster hybrid cells using human leukocyte antigen (HLA) typing antisera. The parental human cells exhibited reactivity against HLA typing serum 3 only. Most of the hybrids evaluated retained reactivity against this typing serum, and a subset of these displayed reactivity against one or more additional typing sera (i.e., sera 1, 2, 9, and 10) for which the human parental cell was negative.
Immunostaining for HLA antigens may be used for detecting hybrids of parental human cells with differing HLA types, therefore conferring limited utility of this approach for detecting intra-species (human × human) cell hybrids [44, 45]. The results of HLA typing of a human × human hybridoma cell line [46] are displayed in Table 2.
Parameter
Parental cell lines
Hybrid cell line
GM15006TGOB
ECEBV
GMEC-101
Chromosomes (mean ± standard deviation)
38 ± 3
38 ± 2
84 ± 7
HLA type
A2
A1,2
A1,2
B18
B5,17
B17
C7
C6,7
C7
Bw6
Bw4
Bw4,6
DR5
DR6
DR5,6
Table 2.
Authentication of a human × human hybridoma cell line using HLA typing (data from [46]).
As with isoenzyme analysis, immunostaining for surface antigens should be performed as soon as possible once a hybrid cell is created. The results may not in all cases remain the same throughout management of the cell culture over time. For instance, a loss of one or more of the parental surface antigen reactivities may coincide with loss of chromosomal material, and perhaps function, with time in culture.
2.3. Karyotypic (cytogenetic) analysis
Karyotypic analysis of inter-species hybrid cells enables an investigator to visualize the rearrangement and addition/deletion of chromosomes that are typically (but not always) observed in such hybrids as a result of the fusion of the two parental cells (Tables 1 and 2). The analysis may amount to determination of modal chromosome number and/or the range of chromosomal numbers observed in a set of metaphase spreads [38, 45]. The chromosomes comprising the karyotype may also be analyzed for morphology (telocentricity, acrocentricity, and banding pattern analysis, see Scheme 1), enabling assignment of chromosomes to one parental species or the other [26, 32, 36, 46, 47].
Scheme 1.
Part 1. Schema for chromosomal structure. Part 2. Human × mouse karyotype from [36]. The arrow indicates the single human submetacentric chromosome among numerous telocentric mouse chromosomes.
Jacobsen and co-workers [22] used fluorescence in situ hybridization (FISH) to demonstrate inter-species cell hybrids between human breast cancer and mouse stromal cells in patient-derived xenografts. The authors labeled human and mouse Cot-1 DNA (enriched in repetitive DNA sequences) with different fluorophores and used these as FISH probes. They were able to highlight the origin of individual nuclei in formalin-fixed, paraffin-embedded tissue sections, and the origin of individual chromosomes in metaphase spreads, and were able to detect hybrid chromosomes consisting of both human and mouse DNA.
At the time of creation, hybrid cells contain a complement of chromosomes, a portion of which are attributable to one of either parental cells, while some may be of unknown origin (Table 1). Inter-species chromosomal rearrangements may also occur in somatic cell hybrids [26]. In many, but not all cases, loss of chromosomes attributed to one or the other parental cell is experienced as the hybrid cells are cultured [26, 31, 32, 35, 36, 46].
2.4. DNA content
Measurement of total or nuclear DNA content is used in characterization of somatic cell hybrids, but is not necessarily intended as an identity test for authenticating such cells. The excess number of chromosomes present in certain cell hybrids relative to the parental cells (discussed above) is also reflected in an increase in DNA content in the hybrid cells. This increase may be detected using microspectrophotometric analysis for nuclear DNA [38] or flow cytometric analysis of propidium iodide-stained cells for total DNA [32]. For instance, while authenticating a series of human × bovine hybrid cell lines, van Olphen and Mittal [32] found that the total DNA content of the hybrid cells was 51–77% greater than the average value for the parental cells (Table 1).
Levels of nuclear DNA in bovine × mouse hybrid cells corresponded to the relative increases in chromosome count for the hybrids [38]. A hybrid with mean chromosomal count of 53 (vs. parental values of 44 and 44) was found to have nuclear DNA content similar to the parental mouse cell, while a hybrid with mean chromosome count of 89 displayed a bimodal nuclear DNA content, with one peak similar to that of the parental mouse cell and another peak at around twice the parental cell peak value [38].
Both total DNA and chromosome count for a hybrid cell may evolve with continued passage of a culture, due to the propensity for loss of chromosomes derived from one or both parental cells, as mentioned above.
2.5. Nucleic acid sequence-based methods
The ability to detect intra-species and inter-species cell hybrids has been greatly facilitated by the development of nucleic acid sequencing methods, such as DNA barcoding (PCR- or sequence-based approaches targeting mitochondrial genes), STR analysis, and next generation sequencing.
2.5.1. DNA barcoding
Ono et al. [48] used a nested PCR targeting the cytochrome b gene of 7 animal species (human, mouse, rat, rabbit, cat, cow, and pig) to authenticate two inter-species hybrid cell lines. These included the 4G12 hybridoma cell line (human B lymphocyte × mouse myeloma) and the N18-RE-105 hybridoma cell line (mouse glioma × rat neural retina). Cytoplasmic isoenzymes from the two hybridoma cell lines were found to display human- or rat-specific migration patterns in isoenzyme analysis, but yielded a result expected for mouse in the nested PCR (Figure 3). The authors concluded that the preferential retention of mouse mitochondria in hybrid cells in which one of the parental cells was mouse, as observed also by Attardi and Attardi [47], diminishes the utility of the nested PCR method for identifying inter-species cell hybrids.
Figure 3.
Use of nested PCR to evaluate a human × mouse hybrid cell line [4G12] and a mouse × rat hybrid cell line [N18-RE-105]. Multiplex group 1 (targeting human, mouse, rat, rabbit, cat, cow, and pig) or the corresponding species-specific primer pairs were used. Note that only the mouse DNA is detected in these two hybrid cells (from [48]).
2.5.2. STR profiling
Chan et al. [49] used STR profiling to identify presumed intra-species human hybrid cell lines comprised of HeLa × EBV-negative NPC (Epstein-Barr virus-negative nasopharyngeal carcinoma) cells. Four EBV-negative NPC cell lines (CNE-1, CNE-2, HNE-1, and HNE-2) were found to have STR profiles similar to each other, and also shared at least one allele with HeLa across 16 STR loci, as well as additional alleles at several of the STR loci that were attributed to an unknown EBV-negative NPC cell. High-throughput RNA sequencing by Strong et al. [50] resulted in similar conclusions and raised similar concerns for three other EBV-negative NPC cell lines (HONE-1, AdAH, and NPC-KT).
Because these particular EBV-negative NPC cell lines have additional alleles, they do not satisfy the usual match criteria for human cell line authentication [51]. However, it is important to consider all available evidence when deciding if cross-contamination has occurred. The data from Chan et al. [49] showed that CNE-1, CNE-2, HNE-1, and HNE-2 carry an allelic variant (D13S317 13.3) that is characteristic of HeLa derivatives [51]. Strong et al. [50] showed that CNE-1, CNE-2, HONE-1, AdAH, and NPC-KT carry human papillomavirus 18 (HPV18), which is an unexpected finding for NPC cell lines, and display viral and cellular genomic rearrangements that are consistent with HeLa. Looking at all the evidence, it is reasonable to conclude that these EBV-negative NPC cell lines represent not simply cross-contamination with HeLa, but rather somatic cell hybridization with HeLa.
The mechanism responsible for somatic cell hybridization in these seven EBV-negative NPC cell lines is not known. Cell-cell fusion may have occurred between HeLa and an unknown NPC cell line through exposure to Sendai virus. NPC-KT, one of the cell lines investigated by Strong et al. [50], was established by using Sendai virus to fuse AdAH and primary NPC cells [52]. NPC-KT also carried EBV, which can cause cell–cell fusion in monolayer cultures [5, 53]. If the originating laboratory unknowingly performed this work on a culture that was cross-contaminated with HeLa, it may have resulted in a HeLa fusion cell line, which may have subsequently cross-contaminated other cell lines used by the NPC research community. HeLa cells also contain the gene for HPV18 viral protein E5, which is fusogenic [54]. The E5 protein of HPV16 is a fusogenic membrane protein and if expressed in two cells, the cells can fuse [55, 56]. So if HeLa and another cell line expressed the HPV18 analogue protein E5, this could have also induced fusion.
Yoshino et al. [33] used an STR profiling approach to authenticate a series of mouse cell lines, including an inter-strain hybrid (Balb/c mouse × C3H/He mouse) cell line. In this approach, F1 hybrid cells derived from the two parental mouse strains displayed different alleles at each locus, corresponding to the alleles contributed by the two parental strains. Loss of heterozygosity occurring during extended culture was thought to result in loss of one of the parental alleles at the D5 Mit201.1 locus of the dinucleotide STR marker (Table 3).
Strain/cell line
Size of amplicons for alleles at STR loci
D1 Mit159.1
D2 Mit395.1
D4 Mit170.1
D5 Mit201.1
D13 Mit256.1
D17 Mit51.1
Parental Balb/c
141.8
135.5
242.5
94.9
88.3
155.1
Parental C3H/He
185.1
123.8
236.4
92.5
78.4
140.1
Hybrid UV.CC3.11.1
142.0, 185.2
135.5, 123.9
242.6, 236.4
94.8
88.4, 78.5
155.2, 140.2
Table 3.
Authentication of an inter-strain hybrid (mouse) cell line by STR profiling (data from [33]).
Almeida et al. [34] described results obtained during authentication of an intra-strain (Balb/c mouse) hybridoma (P3X63Ag8.653 × Balb/c mouse splenic cell). In this case, not unexpectedly, identical alleles were detected for eight of nine STR loci evaluated. At the mouse STR 9-2 locus, the parental P3X63Ag8.653 cell was heterozygous, displaying alleles with 15 and 16 repeats, while the hybrid cell contained only the allele with 15 repeats.
Authentication of hybridoma cell lines is difficult, because of the inbred rodent populations that are used for hybridoma generation. Koren et al. [57] proposed a unique solution using degenerate primers to amplify and sequence the variable regions of the monoclonal antibodies produced by their hybridoma cell lines. Because these regions are highly diverse, they can potentially be used to uniquely identify the hybridoma cell line from which a monoclonal antibody is generated. Koren et al. [57] used this approach to resolve a misidentified cell line in their own laboratory, but the method would be useful for any laboratory working with hybridoma cell lines.
2.5.3. Next generation sequencing
Inter-species and intra-species cell fusion may be detectable by next generation sequencing techniques because of the extensive amount of DNA sequencing and the unbiased selection of the DNA segments (i.e., not using species-specific primers for PCR or selection of DNA fragments). A difficulty may occur in genomic regions that are highly conserved between species for which only small sequence differences exist (e.g., a single or a few bases). In such cases, it may be difficult to determine whether the observed difference is a single nucleotide variation (SNV) between two species or between two samples from the same species. Also, SNPs/SNVs are generally transitional sequence changes (i.e., either purine to purine or pyrimidine to pyrimidine) and may not provide sufficient information to determine whether a sample contains cells from two different species or from two different individuals of the same species. To overcome this difficulty, one must sequence DNA segments that are highly variable and unique to different individuals. These might include human, mouse [34], or rat [58, 59] STR and human [60, 61] or mouse SNP arrays [62, 63]. Multiple genomic regions must be evaluated for those cases in which a few or even a single chromosome from one species is retained by the hybrid cell, as is the case with many hybridoma cell lines.
3. Discussion
Hybrid cell lines represent a special problem for the various approaches that have been utilized for authentication up to now. Firstly, the endpoints that are used in cell authentication assays are ultimately, if not directly, dependent upon the genetic make-up of the cell. Intra-species and inter-species hybrid cells are difficult to test because they contain an assortment of genetic material conferred from the two parental cell types during the fusion process. Thus, specific isoforms of enzymes, the presence or absence of surface antigens, chromosome count, and total DNA content are each subject to the assortment of genetic material that is present in the hybrid cell line following the fusion process. This difficulty also applies to the molecular-based methods that are so useful for determining the authenticity of cells. Thus, one cannot predict, in advance, the results that will be obtained during authentication of a hybrid cell using one of these analytical techniques.
Secondly, not all of the genetic material in the hybrid cell is stable, as it is not uncommon for one or more chromosomes to be lost from hybrid cells on continued passage of the culture. This means that the authentication profile of a hybrid cell may evolve over time in culture.
Due to these considerations, a hybrid cell should be evaluated as soon as possible after fusion to get a baseline (reference) profile. Any drift or change in subsequent profiles may imply changes within the chromosome number or expression profiles. The profile of authentication resulting from one or more of these methods can then be used as a sort of fingerprint or reference against which subsequent authentication can be compared (as in authentication of a master cell bank or a working cell bank). Evolution of such a reference pattern may occur as chromosomes are lost, sometimes quite soon following fusion, from a hybrid during continued culture. This evolution typically involves the loss of characteristics of one of the parental cells (be it parental chromosome(s), species-specific isoenzyme bands or hybrid bands, loss of heterozygosity in SNP or STR profiles, loss of surface staining characteristic of one of the parental cells, etc.). On the other hand, gains in chromosome counts, addition of new isoenzyme bands, appearance of new alleles in SNP or STR profiles, or increases in DNA content with time in culture would not be expected, and such would be considered a red flag during authentication. For instance, such a result might indicate the presence of a cross-contaminating cell type.
4. Executive summary
Fusion of two different cell types to create an inter-species or intra-species hybrid results in an unpredictable assortment of genetic material derived from one or the other parental cell into the hybrid.
The outcome of the fusion process in terms of genetic content contributed by the two parental cells will impact the results of the methodologies typically used for determining cell line authenticity.
Isoenzyme analysis may indicate the presence of electrophoretic bands migrating as expected for one parental cell, the other parental cell, or bands migrating differently than expected for either parental cell.
Hybrid cells may retain surface antigens characteristic of one parental cell or the other, or of both.
Chromosome number (total, and number derived from one parental cell or the other) and total DNA content will vary from hybrid to hybrid.
Human chromosomes found in inter-species hybrid cells tend to be unstable, and are often lost over time in culture.
Regardless of the authentication method to be used, it is recommended that a baseline evaluation be performed as soon as possible after the fusion process used to create the hybrid cell, and that the result be used as a reference against which future authentication results may be compared.
5. Future perspectives
Hybrid cell lines require new methods to ensure that cell-cell fusion is detected and such cultures can be authenticated to demonstrate their validity as research models. Detection of spontaneous cell-cell fusion is particularly important. Somatic cell hybridization may arise when using feeder layers in vitro or when working with patient-derived xenograft models in vivo. In many cases, cell–cell fusion is associated with increased tumorigenicity or the development of malignant behavior in adjacent cell populations [21, 22]. This has the potential to alter the behavior of patient-derived xenograft models, which may be used as the final step before a novel drug proceeds to clinical evaluation [64].
Current authentication methods are not always effective to detect hybrid cell lines. The advantages and limitations of the available methods are displayed in Table 4. Common to all methods is the fact that the chromosomal contributions from each parental cell are not possible to predict in advance. This means that chromosomal makeup and number and corresponding genetic information (e.g., surface antigens, HLA types, enzyme isoforms, alleles at STR loci) will be unique to each fusion cell. In hybrid cells, STR profiles become more complex and difficult to interpret, while mitochondrial-based methods may not be effective for species detection if mitochondria from one species are retained preferentially (as is true for the mouse). However, many methods can be optimized to allow for detection of cell-cell hybrids. For example, SNP genotyping is increasingly used for cell line authentication and has been used as a test method for patient-derived xenograft models [64]. SNP panels could be modified to include species-specific marker sets, or human and mouse SNP panels could be run in parallel to confirm species and strain identifications and search for additional markers. Although this type of comprehensive assessment is not usually performed, it could be incorporated into testing pipelines if laboratories are aware of the spontaneous (unintentional) cell fusion issue and look specifically for such markers of cell fusion. A role has been suggested for cell-cell fusion in cancer, stem cell plasticity, and trans-differentiation [17, 18, 19, 20, 54, 59, 65, 66, 67]. A better set of tools is needed to explore hybrid cell lines and the role of somatic cell hybridization in health and disease.
Method
Principle
Advantages
Disadvantages
Isoenzyme analysis
Electrophoretic mobilities of cytosolic enzymes in the fusion cell correspond to one or both parental cell isoforms
Rapid; inexpensive; visual endpoint; useful for inter-species hybrids
Reagents no longer commercially available; results must be compared to a reference result; certain isoforms may be lost with continued passage of the hybrid cells
Immunostaining
Surface antigens of one or both parental cells may be retained
Rapid, visual endpoint; useful for inter-species hybrids; HLA immunostaining enables detection of intra-species (human) fusion cells
Requires species- or HLA type-specific immunostaining reagents and fluorescent microscopy; results must be compared to a reference result; certain surface antigens may be lost with continued passage of the hybrid cells
Karyotyping (cytogenetic analysis)
Chromosomes contributed by two parental cells may be directly observed in the fusion cell
Visual endpoint; useful for inter-species hybrids; can directly determine chromosomal makeup derived from the parental cells; useful for inter-species hybrids
Preparing and interpreting karyotypes takes expertise; human chromosomes in inter-species hybrids are often lost with passage in culture
DNA content
Fusion cells may contain more total DNA content than either parental cell
Total DNA content is simple to measure; DNA content is useful in detecting intra- as well as inter-species hybrid cells
Total DNA content in hybrid cells is often not stable with passage in culture as chromosomes may be lost
DNA barcoding
Mitochondrial DNA sequences are conserved within species
Rapid; DNA barcoding is used for species of origin confirmation of cells
Nested PCR must be created with species-specific primers for parental cells; preferential retention of mouse mitochondria in inter-species bybrid cells diminishes utility of this method
STR profiling
Multiple (8 or more) STR loci provide identity to the donor level
Rapid; STR profiling can enable authentication of human, dog, or mouse cells to the individual donor level; useful for authenticating mouse hybridoma cells
Not typically useful for inter-species hybrid cells; loss of heterozygosity during extended passage in culture may result in loss of STR alleles
Next generation sequencing
Agnostic sequencing of variable DNA sequences such as STR or SNP arrays
Detects inter- and intra-species hybrid cells
Multiple genomic regions must be evaluated in hybrids containing few or single chromosomes from one of the parental cells
Table 4.
Limitations and advantages of methods for authenticating hybrid cells.
Abbreviations
DNA
deoxyribonucleic acid
EBV
Epstein-Barr virus
FISH
fluorescence in situ hybridization
HHV-8/KSHV
herpesviruses-8/Kaposi sarcoma herpesvirus
HLA
human leukocyte antigen
HPV
human papillomavirus
HTLV-1
human T-cell lymphotropic virus type 1
NPC
nasopharyngeal carcinoma
PCR
polymerase chain reaction
RFLP
restriction length fragment polymorphism
RNA
ribonucleic acid
SNP
single nucleotide polymorphism
SNV
single nucleotide variation
STR
short tandem repeat
SV40
simian virus 40
\n',keywords:"cell fusion, hybrid cell line, authentication, immunostaining, isoenzyme analysis, karyotyping, STR profiling, SNP profiling",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/63598.pdf",chapterXML:"https://mts.intechopen.com/source/xml/63598.xml",downloadPdfUrl:"/chapter/pdf-download/63598",previewPdfUrl:"/chapter/pdf-preview/63598",totalDownloads:1015,totalViews:166,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:1,impactScore:0,impactScorePercentile:11,impactScoreQuartile:1,hasAltmetrics:1,dateSubmitted:"March 23rd 2018",dateReviewed:"August 2nd 2018",datePrePublished:"November 5th 2018",datePublished:"January 23rd 2019",dateFinished:"September 17th 2018",readingETA:"0",abstract:"Hybrid (both intra-species and inter-species) cell lines arise through intentional or nonintentional fusion of somatic cells having different origins. Hybrid cell lines can pose a problem for authentication testing to confirm cell line identity, since the results obtained may not conform to the results expected for the two parental cell types. Thus, depending on the identity testing methodology, a hybrid cell may display characteristics of one of the parental cell type or of both. In some instances, the hybrid cell line may display characteristics that are different from those displayed by either parental cell type; these differences may not necessarily indicate cellular cross-contamination. Testing should be performed as soon as possible after an intended fusion has occurred, so that a baseline reference profile is available for later comparison. In this article, we describe the various approaches that have been used for identifying hybrid cell lines and the results that might be expected when using various technologies for this purpose.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/63598",risUrl:"/chapter/ris/63598",book:{id:"6964",slug:"cell-culture"},signatures:"Raymond W. Nims, Amanda Capes-Davis, Christopher Korch and\nYvonne A. Reid",authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Methodologies for authenticating hybrid cell lines",level:"1"},{id:"sec_2_2",title:"2.1. Isoenzyme analysis",level:"2"},{id:"sec_3_2",title:"2.2. Immunostaining for surface antigens",level:"2"},{id:"sec_4_2",title:"2.3. Karyotypic (cytogenetic) analysis",level:"2"},{id:"sec_5_2",title:"2.4. DNA content",level:"2"},{id:"sec_6_2",title:"2.5. Nucleic acid sequence-based methods",level:"2"},{id:"sec_6_3",title:"2.5.1. DNA barcoding",level:"3"},{id:"sec_7_3",title:"Table 3.",level:"3"},{id:"sec_8_3",title:"2.5.3. Next generation sequencing",level:"3"},{id:"sec_11",title:"3. Discussion",level:"1"},{id:"sec_12",title:"4. Executive summary",level:"1"},{id:"sec_13",title:"5. Future perspectives",level:"1"},{id:"sec_16",title:"Abbreviations",level:"1"}],chapterReferences:[{id:"B1",body:'Cell Fusion. Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Dordrecht: Springer; 2008. DOI: 10.1007/978-1-4020-6754-9_2621'},{id:"B2",body:'Somatic Cell Hybrids. Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Dordrecht: Springer; 2008. DOI: 10.1007/978-1-4020-6754-9_15854'},{id:"B3",body:'Ephrussi B, Weiss MC. Interspecific hybridization of somatic cells. Proceedings of the National Academy of Science, USA. 1965;53:1040-1042'},{id:"B4",body:'Gao P, Zheng J. Oncogenic virus-mediated cell fusion: New insights into initiation and progression of oncogenic viruses–related cancers. Cancer Letters. 2011;303:1-8'},{id:"B5",body:'Hussain T, Mulherkar R. Lymphoblastoid cell lines: A continuous in vitro source of cells to study carcinogen sensitivity and DNA repair. International Journal of Molecular and Cellular Medicine. 2012;1:75-87'},{id:"B6",body:'Pedrazzoli F, Chrysantzas I, Dezzani L, Rosti V, Vincitorio M, Sitar G. Cell fusion in tumor progression: The isolation of cell fusion products by physical methods. Cancer Cell International. 2011;11:32. https://doi.org/10.1186/1475-2867-11-32'},{id:"B7",body:'Scheurich P, Zimmermann U, Mischel M, Lamprecht I. Membrane fusion and deformation of red blood cells by electric fields. Zeitschrift für Naturforschung C. 1980;35:1081-1085'},{id:"B8",body:'Pilwat G, Richter H-P, Zimmermann U. Giant culture cells by electric field-induced fusion. FEBS Letters. 1981;133:169-174'},{id:"B9",body:'Zimmermann U. Electric field-mediated fusion and related electrical phenomena. Biochimica et Biophysica Acta. 1982;694:227-277'},{id:"B10",body:'Zimmermann U, Vienken J. Electric field-induced cell-to-cell fusion. Journal of Membrane Biology. 1982;67:165-182'},{id:"B11",body:'Zimmermann U, Vienken J, Pilwat G, Arnold WM. Electro-fusion of cells: Principles and potential for the future. Ciba Foundation Symposia. 1984;103:60-85'},{id:"B12",body:'Zimmermann U, Urnovitz HB. Principles of electrofusion and electropermeabilization. Methods in Enzymology. 1987;151:194-221'},{id:"B13",body:'Trontelj K, Rebersek M, Kanduser M, Serbec VC, Sprohar M, Miklavcic D. Optimization of bulk cell electrofusion in vitro for production of human-mouse heterohybridoma cells. Bioelectrochemistry. 2008;74:124-129'},{id:"B14",body:'Hock BD, Roberts G, McKenzie JL, Gokhale P, Salm N, McLellan AD, et al. Exposure to the electrofusion process can increase the immunogenicity of human cells. Cancer Immunology and Immunotherapy. 2005;54:880-890'},{id:"B15",body:'Schoeman RM, van den Beld WTE, Kemna EWM, Wolbers F, Eijkel JCT, van den Berg A. Electrofusion of single cells in picoliter droplets. Scientific Reports. 2018;8:3714. DOI: 10.1038/s41598-018-21993-8'},{id:"B16",body:'Willkomm L, Bloch W. State of the art in cell-cell fusion. Methods in Molecular Biology. 2015;1313:1-19'},{id:"B17",body:'Bastida-Ruiz D, Van Hoesen K, Cohen M. The dark side of cell fusion. International Journal of Molecular Science. 2016;17(pii):E638. DOI: 10.3390/ijms17050638'},{id:"B18",body:'Zhou X, Merchak K, Lee W, Grande JP, Cascalho M, Platt JL. Cell fusion connects oncogenesis with tumor evolution. American Journal of Pathology. 2015;185:2049-2060'},{id:"B19",body:'Duelli D, Lazebnik Y. Cell fusion: A hidden enemy? Cancer Cell. 2003;3:445-448'},{id:"B20",body:'Duelli D, Lazebnik Y. Cell-to-cell fusion as a link between viruses and cancer. Nature Reviews in Cancer. 2007;7:968-976'},{id:"B21",body:'Goldenberg DM. Horizontal transmission of malignancy by cell-cell fusion. Expert Opinions in Biological Therapy. 2012;12:S133-S139'},{id:"B22",body:'Jacobsen BM, Harrell JC, Jedlicka P, Borges VF, Varella-Garcia M, Horwitz KB. Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium. Cancer Research. 2006;66:8274-8279'},{id:"B23",body:'Searles SC, Santosa EK, Bui JD. Cell-cell fusion as a mechanism of DNA exchange in cancer. Oncotarget. 2017;9:6156-6173'},{id:"B24",body:'Camps J, Salaverria I, Garcia MJ, Prat E, Beá S, Pole JC, et al. Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines. Leukemia Research. 2006;30:923-934'},{id:"B25",body:'Köhler G, Milstein C. Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. European Journal of Immunology. 1976;6:511-519'},{id:"B26",body:'Raimondi E, Mezzelani A, Castiglioni B, Moralli D, Rognoni G, De Carli L. Characterization of hamster-bovine somatic cell hybrids by in situ hybridization and chromosome banding. Hereditas. 1993;118:191-194'},{id:"B27",body:'Melmed S, Fagin JA. Isolation and characterization of rat-mouse somatic cell hybrids secreting growth hormone and prolactin. Experimental Cell Research. 1986;162:475-485'},{id:"B28",body:'Gauck D, Keil S, Niggemann B, Zänker KS, Dittmar T. Hybrid clone cells derived from human breast epithelial cells and human breast cancer cells exhibit properties of cancer stem/initiating cells. BMC Cancer. 2017;17:515. DOI: 10.1186/s12885-017-3509-9'},{id:"B29",body:'Ramakrishnan M, Mathur SR, Mukhopadhyay A. Fusion-derived epithelial cancer cells express hematopoietic markers and contribute to stem cell and migratory phenotype in ovarian carcinoma. Cancer Research. 2013;73:5360-5370'},{id:"B30",body:'Giavazzi R, Scholar E, Hart IR. Isolation and preliminary characterization of an adriamicyn-resistant murine fibrosarcoma cell line. Cancer Research. 1983;43:2216-2222'},{id:"B31",body:'van der Noordaa J, van Haagen A, Walboomers JMM, van Someren H. Properties of somatic cell hybrids between mouse cells and simian virus 40-transformed rat cells. Journal of Virology. 1972;10:67-72'},{id:"B32",body:'van Olphen AL, Mittal SK. Development and characterization of bovine × human hybrid cell lines that efficiently support the replication of both wild-type bovine and human adenoviruses and those with E1 deleted. Journal of Virology. 2002;76:5882-5892'},{id:"B33",body:'Yoshino K, Saijo K, Noro C, Nakamura Y. Development of a simple method to determine the mouse strain from which cultured cells originated. Interdisciplinary Biology Central. 2010;2:1-9. DOI: 10.4051/ibc.2010.2.4.0014'},{id:"B34",body:'Almeida JL, Hill CR, Cole KD. Mouse cell line authentication. Cytotechnology. 2014;66:133-147'},{id:"B35",body:'Weiss MC, Green H. Human-mouse hybrid cell lines containing partial complements of human chromosomes and functioning human genes. Proceedings of the National Academy of Science, USA. 1967;58:1104-1111'},{id:"B36",body:'Migeon BR, Miller CS. Human-mouse somatic cell hybrids with single human chromosome (group E): Link with thymidine kinase activity. Science. 1968;162:1005-1006'},{id:"B37",body:'Nichols EA, Ruddle FH. A review of enzyme polymorphisms, linkage and electrophoretic conditions for mouse and somatic cell hybrids in starch gels. Journal of Histochemistry and Cytochemistry. 1973;21:1066-1081'},{id:"B38",body:'Chinchar VG, Floyd AD, Chinchar GD, Taylor MW. Characterization of hybrids between bovine (MDBK) and mouse (L-cells) cell lines. Biochemical Genetics. 1979;17:133-148'},{id:"B39",body:'Machado JZ, de Miranda ACS, Cruz AS. G6PD and MDH isoenzyme electrophoresis for cell lines authentication. Virus Reviews and Research. 2016;21:1-4'},{id:"B40",body:'Nims RW. Historical and current methods for detecting inter- and intra-species cell mixtures and thereby assuring cell line purity. In: Tsongalis GJ, editor. Advances in Molecular Pathology. Vol. 1. 2018. In press'},{id:"B41",body:'van Someren H, Westerveld A, Hagemeijer A, Mees JR, Meera Khan PM. Human antigen and enzyme markers in man-Chinese hamster somatic cell hybrids: Evidence for synteny between the HL-A, PGM3, ME1, and IPO-B loci. Proceedings of the National Academy of Science, USA. 1974;71:962-965'},{id:"B42",body:'Croce CM, Talavera A, Basilico C, Miller OJ. Suppression of production of mouse 28S ribosomal RNA in mouse-human hybrids segregating mouse chromosomes. Proceedings of the National Academy of Science, USA. 1977;74:694-697'},{id:"B43",body:'Kano K, Baranska W, Knowles BB, Koprowski H, Milgrom F. Surface antigens on interspecies hybrid cells. Journal of Immunology. 1969;103:1050-1060'},{id:"B44",body:'Gallagher T, Chardonnet Y, Viac J, Patet J, Lefèvre A. Antigenic immunostaining patterns in somatic hybrids of human HeLa cells and mouse fibroblasts 3T3.4E propagated in conventional medium and delipidized serum. Virchows Archiv Part B Cell Pathology Including Molecular Pathology. 1989;57:339-347'},{id:"B45",body:'Kozbor D, Burioni R, Ar-Rushdi A, Zmijewski C, Croce CM. Expression of members of the immunoglobin gene family in somatic cell hybrids between human B and T cells. Proceedings of the National Academy of Science, USA. 1987;84:4969-4973'},{id:"B46",body:'Hulette CM, Effros RB, Dillard LC, Walford RL. Production of a human monoclonal antibody to HLA by human-human hybridoma technology. American Journal of Pathology. 1985;121:10-14'},{id:"B47",body:'Attardi B, Attardi G. Fate of mitochondrial DNA in human-mouse somatic cell hybrids. Proceedings of the National Academy of Science, USA. 1972;69:129-133'},{id:"B48",body:'Ono K, Satoh M, Yoshida T, Ozawa Y, Kohara A, Takeuchi M, et al. Species identification of animal cells by nested PCR targeted to mitochondrial DNA. In Vitro Cellular and Developmental Biology—Animal. 2007;43:168-175'},{id:"B49",body:'Chan SY-Y, Choy KW, Tsao S-W, Tao Q, Tang T, Chung GT-Y, et al. Authentication of nasopharyngeal carcinoma tumor lines. International Journal of Cancer. 2008;122:2169-2171'},{id:"B50",body:'Strong MJ, Badoo M, Nanbo A, Xu M, Puetter A, Lin Z. Comprehensive high-throughput RNA sequencing analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes. Journal of Virology. 2014;88:10696-10704'},{id:"B51",body:'ANSI/ATCC ASN-0002-2011. Authentication of human cell lines: Standardization of STR profiling. In: https://webstore.ansi.org/RecordDetail.aspx?sku=ANSI%2FATCC+ASN-0002-2011'},{id:"B52",body:'Takimoto T, Furukawa M, Hatano M, Umeda R. Epstein-Barr virus nuclear antigen-positive nasopharyngeal hybrid cells. The Annals of Otology, Rhinology, and Laryngology. 1984;93:166-169'},{id:"B53",body:'Bayliss GJ, Wolf H. Epstein-Barr virus-induced cell fusion. Nature. 1980;287:164-165'},{id:"B54",body:'Gao P, Zheng J. High-risk HPV E5-induced cell fusion: A critical initiating event in the early stage of HPV-associated cervical cancer. Virology Journal. 2010;7:238. DOI: 10.1186/1743-422X-7-238'},{id:"B55",body:'Hu L, Plafker K, Vorozhko V, Zuna RE, Hanigan MH, Gorbsky GJ, et al. Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion. Virology. 2008;384:125-134'},{id:"B56",body:'Hu L, Ceresa BP. Characterization of the plasma membrane localization and orientation of HPV16 E5 for cell-cell fusion. Virology. 2009;393:135-143'},{id:"B57",body:'Koren S, Kosmac M, Colja Venturini A, Montanic S, Curin Serbec V. Antibody variable-region sequencing as a method for hybridoma cell-line authentication. Applied Microbiology and Biotechnology. 2008;78:1071-1078'},{id:"B58",body:'Bryda EC, Riley LK. Multiplex microsatellite marker panels for genetic monitoring of common rat strains. Journal of the American Association for Laboratory Animal Science. 2008;47:37-41'},{id:"B59",body:'Shore SK, Bacheler LT, de Riel JK, Barrows LR, Lynch M. Cloning and characterization of a rat-specific repetitive DNA sequence. Gene. 1986;45:87-93'},{id:"B60",body:'Huang J, Wei W, Zhang J, Liu G, Bignell GR, Stratton MR, et al. Whole genome DNA copy number changes identified by high density oligonucleotide arrays. Human Genomics. 2004;1:287-299'},{id:"B61",body:'Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Lundin P, et al. Large-scale copy number polymorphism in the human genome. Science. 2004;305:525-528'},{id:"B62",body:'Didion JP, Buus RJ, Naghashfar Z, Threadgill DW, Morse HC 3rd, de Villena FP. SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy. BMC Genomics. 2014;15:847. DOI: 10.1186/1471-2164-15-847'},{id:"B63",body:'Morgan AP, Fu C-P, Kao C-Y, Welsh CE, Didion JP, Yadgary L, et al. The mouse universal genotyping array: From substrains to subspecies. G3: Genes, Genomes, Genetics. 2015;6:263-279'},{id:"B64",body:'El-Hoss J, Jing D, Evans K, Toscan C, Xie J, Lee H, et al. A single nucleotide polymorphism genotyping platform for the authentication of patient derived xenografts. Oncotarget. 2016;737:60475-60490'},{id:"B65",body:'Eisenberg LM, Eisenberg CA. Stem cell plasticity, cell fusion, and transdifferentiation. Birth Defects Research, Part C Embryo Today: Reviews. 2003;69:209-218'},{id:"B66",body:'Holland H, Livrea M, Ahnert P, Koschny R, Kirsten H, Meixensberger J, et al. Intracranial hemangiopericytoma: Case study with cytogenetics and genome wide SNP-A analysis. Pathology, Research and Practice. 2011;207:310-316'},{id:"B67",body:'Liu C, Lin J, Li L, Zhang Y, Chen W, Cao Z, et al. HPV16 early gene E5 specifically reduces miRNA-196a in cervical cancer cells. Scientific Reports. 2015;5:7653. DOI: 10.1038/srep07653'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Raymond W. Nims",address:"rnims@rmcpharma.com",affiliation:'
Division of Medical Oncology, University of Colorado Denver, USA
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1. Introduction
Artificial intelligence (AI) technique is the most effective technology used in the modern healthcare area. The rapidly growing accessibility of healthcare medical data and also the advances of big data diagnostic techniques has completed the potential of the current successful uses of artificial intelligence (AI) in healthcare system. With the help of important medical questions, potential artificial intelligence (AI) techniques can disengage healthcare-appropriate information secreted in the huge quantity of data, which can maintain healthcare decision-making. Modern healthcare technology in various medical areas has spread to the several pioneering startups in the world, which helps people in healthier and longer lives. The advances have initially been determined by the beginning of mobility and software, permitting the health sector to digitize several of the pen- and paper-based processes and operations that are presently held up service release. Nowadays, computer software has become far more intelligent and autonomous. These new abilities are discussed under the same cover of machine learning (ML) and artificial intelligence (AI), which are accelerating the tempo of improvement in healthcare. The applications of machine learning (ML) and artificial intelligence (AI) in healthcare region have allowed the area to employ some of its major challenges in particular domains like drug discovery, personal genetics, and disease identification and management. Every time an innovative technical tool comes into the healthcare system, it also faces several challenges. Most of the common issues of artificial intelligence (AI) technique in healthcare system are regulatory compliance requirements, patient and provider adoption, and also lack of data exchange. The Artificial intelligence (AI) has moved from all of these concerns, reducing the areas in which it can accomplish something. The purpose of artificial intelligence (AI) and machine learning (ML) in healthcare system is redesigning the industry and creating what was once impracticable into a real truth. For artificial intelligence (AI)/machine learning (ML) to take its place in the healthcare system, sustained access to appropriate data is necessary to succeed. Artificial intelligence (AI) can be used to analyze and identify patterns in large and complex datasets faster and more precisely than has previously been possible. It can also be used to search the scientific literature for relevant studies and to combine different kinds of data, for example, to aid drug discovery. Artificial intelligence (AI) health apps have the potential to empower people to evaluate their own symptoms and care for themselves when possible. Artificial intelligence (AI) systems that aim to support people with chronic health conditions or disabilities could increase people’s sense of dignity, independence, and quality of life, and enable people who may otherwise have been admitted to care institutions to stay at home for longer. Artificial intelligence (AI) depends on digital data, so inconsistencies in the availability and quality of data restrict the potential of artificial intelligence (AI). Also, significant computing power is required for the analysis of large and complex datasets. Clinical practice often involves complex judgments and abilities that artificial intelligence (AI) currently is unable to replicate, such as appropriate knowledge and the ability to read social cues. With the help of machine learning process, structured data like genetic data, electro physical data (EP), and imaging data are properly investigated. Machine learning makes the information analytical algorithms to extract characteristics from the input data. Input data generally in machine learning algorithms involve with patient’s natures as well as the intermittently apprehension healing effects. A patient’s nature generally includes bottom line data, such as gender, disease history, age, gene expressions, electrophysiological data (EP) test, analytical imaging, idea test results, and medicinal symptoms. Support vector machine was also applied in cancer diagnosis. Even supposing complicated data, machine learning represents the support for artificial intelligence (AI). At this moment in time, an innovative advancement is happening in the subfield of neural networks. This has created notable interest in various domains of healthcare science, in addition to drug analysis and also the area of public health. Deep neural networks can implement in addition to the most exceptional human clinicians in specific diagnostic tasks. Also, artificial intelligence techniques are already promising in healthcare-based apps, which can be performed by any network machine like modern smart mobile phone. Artificial intelligence has the ability to address imperative health challenges, but it is limited due to the unavailability of good health data. Employing artificial intelligence (AI) involves some ethical issues including the probable for artificial intelligence (AI) to make mistaken assessments and then the question of responsibility occurs.
2. Artificial intelligence (AI) devices
Basically, artificial intelligence (AI) devices are categorized by two main types: the first one is machine learning (ML) category [1], which generally analyses the structured data, for example, electrophysiological data (EP), genetic data, and imaging data. For healthcare applications, the machine learning (ML) processes try to gather patients’ individuality or understand the possibility of the disease effects [2]. The second type of artificial intelligence (AI) device is the natural language processing (NLP) technique [3], which can take out the information from free or unstructured data such as medical observations or health journals to enhance structured health check data. The natural language processing (NLP) processes objects at revolving contents toward the machine-understandable structured records and can then be considered by machine learning (ML) procedures [4]. Figure 1 explains the road plan from medical data making, during natural language processing (NLP) data improvement and machine learning (ML) data investigation, to medical judgment creating. In this figure, the road plan starts and ends with medical activities. As dominant as artificial intelligence (AI) procedures, they can be inspired by medical/healthcare troubles and also be practical to help out the medical performance at the end.
Figure 1.
The road plan from generation of medical data, during natural language processing (NLP) data improvement and machine learning (ML) data investigation.
2.1 Machine learning (ML) processes
Machine learning (ML) builds the data investigative algorithms to extort characteristics from the data. Inputs to machine learning (ML) algorithms consist of patient ‘characters’ and occasionally therapeutic effects of concern. A patient’s characters generally contain bottom line data, for example, gender, age, disease history, and also disease explicit data, for instance, gene expressions, analytical imaging, electrophysiological data (EP) test, objective test results, medication, and medical symptoms. In addition to the attributes of the patients medical results are frequently composed for medical investigation. These contain syndrome pointers, patients’ endurance periods, and quantitative syndrome stages such as the size of tumor. Here jth characteristic of the ith numbers of patient is denoted by Pij and Qi is representing the effect of concern. Regarding whether to integrate the results, machine learning (ML) algorithms can also be separated into two main types: supervised learning and unsupervised learning. One more type is also available named as semisupervised learning. Figure 2 represents all these three types of learning procedures. Unsupervised learning is also identified for feature removal, whereas supervised learning is appropriate for analytical representation by constructing several interactions involving patient individuality (input) and result of concern (output). In recent times, semisupervised learning has been projected as a hybrid involving supervised learning and unsupervised learning, which is appropriate for circumstances wherever the effect is omitted for definite issues.
Figure 2.
Representation of (A) unsupervised learning, (B) supervised learning, and (C) semisupervised learning.
There are two major unsupervised learning techniques available such as (i) principal component analysis (PCA) technique and (ii) clustering technique. Principal component analysis is basically for element reduction, mainly while the characteristic is documented in a huge number of elements, such as the number of genes in a genome-mixt connection revise. Principal component analyses (PCA) project the data on a small number of principal component (PC) guidelines, without trailing in excess of information regarding the issues. Occasionally, PCA is used to decrease the element of the data, after which clustering technique is used to fraction the issues. All these fraction issues with related characteristics are gathered together, without applying any result information. This algorithm’s result output helps the cluster tags for the patients throughout maximizing as well as minimizing the parallel of the patients and also involving the clusters. These accepted clustering algorithms contain (i) Gaussian mixture clustering, (ii) K-means clustering, and (iii) hierarchical clustering. Alternatively, supervised learning reflects on the topics’ outcomes in cooperation with their characteristics and goes via a definite training procedure to find out the finest outputs connected through the inputs, which are nearby the standard outcomes. Generally, the formulations of output contrast through the concern outcomes. Such that, the outcome can be the possibility of receiving an exact clinical result, the projected value of a disease stage or the projected endurance time. Evaluated by unsupervised learning and supervised learning, which offers extra clinically applicable results; therefore Artificial Intelligence (AI) relevance in healthcare system most regularly apply supervised learning. Unsupervised learning may be applied as a component of the preprocessing stage to or find out subgroups or decrease dimensionality, which consecutively makes summarizing supervised learning stage more capable. Appropriate methods contain logistic regression, linear regression, decision tree, naïve Bayes, random forest, discriminate analysis, nearest neighbor, neural network, and support vector machine (SVM). Neural network and SVM are the most accepted supervised learning methods in healthcare applications [5]. The mechanisms of neural networks and support vector machine (SVM) techniques process together with relevant examples in the cardiovascular disease, neurological disease, and cancer.
2.2 Neural network
Neural network is basically known as the expansion of linear regression for confining the difficult nonlinear relationships dividing the input parameters and outcome data. In this neural network, the relations involving the input parameters and the outcome are represented throughout the multiple unknown layer grouping of preindividual functional. The aim is to calculate approximately the weights via input data and also the outcome data so that the average error involving the outcome and their calculation is reduced. Here, this technique is described via following some examples. Neural network was used in stroke diagnosis [6], where the input parameters were given as Xi1, …, Xip and p = 16 stroke-related symptoms, together with acute confusion, problem of vision and mobility, paresthesia of the leg or arm, etc. Yi represents the binary outcome, where Yi = 1/0 represents that the ith patient has or does not have stroke. The output factor of importance is the possibilities of stroke (ai), which represents the equation given below:
ai=hΣK=1Dw2lfkΣl=1pw1lXil+w10+w20E1
In this equation, w10 and w20 are not equal to zero, where Xij, fk = 0; fks and h are prespecified functions, which indicate that the weighted grouping influences the disease threat as a whole. Figure 3 represents the neural network system.
Figure 3.
Neural network diagram.
The instruction’s aim is to find out the weight of wij, which can minimize the calculation in accuracy given by Σi=1nYi−ai2. The minimization can be done via standard optimization algorithms, for instance, local quadratic estimate or gradient decline optimization, which are integrated in both R and MATLAB software. The latest data were issued from the similar population and the results of wij are also applied to calculate the outcomes rooted in their particular characters [7]. This is the same as methods have been applied to identify cancer treatment [8], where the input efforts and outcomes are the principal components (PC) predictable from 6567 genes and the tumor groups. A neural network was applied to identify breast cancer, where the inputs represent the surface information from mammographic images and where the outcomes are tumor indicators [9]. Another problematical neural network model was analyzed to identify Parkinson’s disease derived where the input parameters are motor and nonmotor indications and neuroimages [10].
2.3 The support vector machine (SVM)
The supporting vector machine is mostly applied for categorizing the topics into two different clusters, where the result Yi, Yi = −1 or 1 indicates whether the ith patient is in set 1 or 2 correspondingly. This procedure can be completed for circumstances with more than 2 sets. The fundamental hypothesis is that the subject matters can be divided into two different groups via a decision boundary distinct on the characteristics Xij, which can be represented as:
ai=Σj=1pwjXij+bE2
where wj represents the weight put on the jth characteristic to mark edits’ comparative implication on moving the outcome between the others. If ai > 0, the ith patient is categorized to group 1, that is, Yi = −1; and if ai < 0, the patient is categorized to group 2, that is, Yi = 1. Furthermore, assuming that the new patients come from the same population, the resulting Wj can be applied to classify these new patients based on their traits. An important property of SVM is that the determination of the model parameters is a convex optimization problem so the solution is always global optimum. Additionally, many obtainable rounded optimization technique applications are readily available for the SVM performance. SVM has been widely applied in healthcare research. For example, SVM was used to recognize imaging biomarkers of psychiatric and neurological disease [11]. SVM was also applied in cancer diagnosis [12]. SVM and other statistical methods can also be used to reach early detection of Alzheimer’s syndrome [13]. SVM was applied to analyze the power of an offline human and device interface, which can control the upper-limb prostheses [14].
2.4 Deep learning method
Deep learning method is a contemporary expansion of the traditional neural network method. Figure 4 represents deep learning like a neural network with multicovers.
Figure 4.
Multilayer neural network.
Rapid growth of current computing allowed deep learning for constructing the neural networks along with huge amount of covers, which is impossible for traditional neural networks. Basically, this technique helps to investigate many critical nonlinear models in the information. One more cause for the recent acceptance of deep learning techniques is owing to the enhancement of the critical and volume of data [15]. Dissimilar to the traditional neural network, this process generally applies more hidden levels in order that the algorithms can handle critical data with different structures [5]. In the healthcare applications, the generally applied deep learning algorithms consist of recurrent neural network, convolution neural network technique, deep neural network, and deep belief network. Convolution neural network is the most accepted one in 2016. The convolution neural network is extended to analyzing the ineptitude of the traditional machine learning algorithms when conducting high dimensional data, that is, data with a huge number of characteristics. Conventionally, the machine learning algorithms are considered to examine data when the number of characteristics is little. The image data are physically high dimensional because each image generally includes thousands of pixels as characteristics. One explanation is to present dimension decrease: primarily preselect an object of pixels as elements and then complete the machine learning algorithms on the ensuing lower dimensional traits. However, heuristic feature selection events may drop the information in the images. Unsupervised learning methods such as clustering or PCA can be applied for data-determined dimension decrease. The convolution neural network was first projected the high-dimensional image investigation [16], where the inputs for convolution neural network are the accurately regulated pixel values on the images. The convolution neural network then transmitted the pixel values in the image throughout weighting in the difficulty layers and variety in the subsampling layers instead. The ultimate output is a recursive purpose of the weighted input values. The weights are skilled to reduce the average error involving the predictions and the outcomes. The performance of convolution neural network has been incorporated in trendy software packages such as Caffe from Berkeley AI Research [17] and Tensor Flow from Google [18]. Recently, the convolution neural network has been effectively executed in the healthcare area to help disease identification. It is used to identify the congenital cataract disease throughout learning the ocular images [19], though it has over 90% accuracy on identification and treatment implication. Convolution neural network was performed to identify skin cancer from clinical images [20]. Convolution neural network is applied to identify referable diabetic retinopathy via the retinal fundus photographs [21]. The specificity and sensitivity of the algorithm are both over 90%, which expressed the usefulness of using the method in the analysis of diabetes. It is importance to declare that in all this type of applications, the presentation of the convolution neural network is competitive beside an experienced physician in the truthfulness for categorizes both usual and disease stages.
2.5 Natural language processing
Genetic data and EP plus image are all machine-comprehensible, that is why the machine learning (ML) algorithms can be straightly presented after quality control processes or appropriate preprocessing. Though huge extents of medical data are like descriptive content, like a substantial examination, operative notes, and an experimental laboratory reports and release abstracts, these are formless and inconceivable for computer programming. Below this background, natural language processing (NLP) targets removing helpful data from the descriptive text to support the medical conclusion making [3]. A natural language processing (NLP) pipeline includes two main components: (i) classification and (ii) text processing. During text processing, the natural language processing (NLP) recognizes a sequence of disease-appropriate keywords at clinical remarks related to the past records [22]. After that, keyword subsets are preferred during analyzing their achievements in the arrangement in the normal abnormal cases. The authorized keywords then enter and enhance the controlled information to support medical choice making. The natural language processing pipelines have been developed to help the medical choice making on attentive treatment preparations and monitoring critical effects. For instance, it was showed that establishment of natural language processing, for analyzing the chest X-ray reports would help the antibiotic assistant system to aware physicians for the probable necessitate for anti-infective therapy [23]. Natural language processing was used to mechanically monitor laboratory-based difficult effects. Moreover, the natural language processing pipelines can also assist with disease analysis [24]. A recognized of 14 cerebral aneurysm disease-associated changeable during executing natural language processing (NLP), based on the clinical remarks [25]. Resulting variables are effectively applied for categorizing the common patients and the patients with cerebral problems, with 86% to 95% accuracy rates on the validation and training trials correspondingly. A natural language processing was implemented to extort the peripheral arterial disease-allied keywords from description clinical remarks. The keywords are then applied to categorize the common patients and the patients who have peripheral arterial disease, which reaches over 90% accurate [22].
3. Artificial intelligence (AI) applications in healthcare system
In spite of few limitations, artificial intelligence (AI) are applied in healthcare system. Researchers mainly focus on the region of major three diseases: cardiovascular disease, nervous system disease, and life-threatening cancer also. In cardiology, [26] explained the prospective uses of the AI system for making a diagnosis of the cardiac diseases with the help of cardiac images. Cardiac stroke is a natural and commonly stirring disease that has an effect on more than 500 million people all around the world. It is the most leading cause of death in world. It has also high medical expenses across the world nearly about US$ 689 billion, which causes serious trouble to patient families [27, 28]. For that reason, research on anticipation and medical treatment for stroke has a great impact. Recently, artificial intelligence (AI) processes have been used in additional and supplementary stroke-connected studies. In stroke-concerned cases, AI procedures help in the three main areas: before time for disease calculation and analysis, healing, and in addition to conclusion forecast and diagnosis assessment. About 85% of the time, stroke is caused by cerebral infarction, that is, thrombus in the vessel. For require of finding pre stroke indication, only some patients could obtain appropriate treatment. A movement-detecting device was developed for predicting early stroke [29]. For model structure resolution, two machine learning algorithms like PCA and genetic fuzzy finite state machine are mainly used. The revealing method is attached with a patient human action detection phase and the starting of the stroke detection phase. Ideally, the typical model is remarkably different from the patient movement, and an attentive model that can detect stroke can stimulate and assess medical action and make it immediately feasible. Correspondingly, a device that is wearable was proposed for gathering data for regular and pathological steps for calculation of stroke [30]. The data can be removed and copied by SVM and unseen Markov models, and this algorithm could suitably organize 91% of information to the exact group. For some identification of the stroke, neuro-imaging processes like CT scan and MRI are also essential for disease estimation. Several studies have attempted to concern machine learning techniques to neuro-imaging data to support with stroke analysis. SVM was used in resting-state functional MRI data, where endophenotypes of motor disability behind stroke were classified and recognized [31]. This algorithm can precisely distinguish patients with a precision of 87.6%. T1-weighted MRI, [32] helps to rearrange the stroke injury. This effect is similar for human-proficient physical injury explanation. Kamnitsas et al. [33] attempted 3D CNN aimed at injury fragmentation in multisculpt brain MRI. It likewise used fully associated provisional casual field representation for ultimate postprocessing of the CNN’s soft segmentation plots. With the help of Gaussian process regression method, stroke anatomical MRI images were analyzed,and also establish the vortex pattern performed well than injury load/area like the expecting elements [34]. Machine learning (ML) techniques are also useful to examine stroke patients with CT scans. A free-floating intraluminal thrombus can be created like injury post stroke, and this is complicated to discriminate by carotid sign in CT imaging. Three machine learning (ML) algorithms were used to categorize two quantitative types: shape analysis with linear classification analysis, SVM, and artificial neural network [35]. Machine learning is also used in expecting and evaluating the presentation for stroke cure. In a critical emergency phase determination, the result of intravenous thrombolysis (tPA) has a sturdy link for the diagnosis per durance rate. With CT scan, SVM can be used for expecting whether the patients by thrombolysis (tPA) cure can build up suggestive intracranial hemorrhage [36]. In SVM, complete brain images were used as input, which acted healthier than traditional radiology-based procedures. For improving the medical result making procedure of thrombolysis (tPA) healing, a stroke treatment model was proposed for investigating perform guiding principle, clinical trials and meta-analysis with Bayesian principle network [37]. The model consisted of 56 different types of variables and 3 decisions aimed at investigating the process for analysis, cure, and effective calculation. An interaction tree was used, where the subgroup investigated suitable thrombolysis (tPA) dosage as per patient individuality, taking into consideration the healing efficacy and the possibility of bleeding [38]. Several issues can influence stroke diagnosis and syndrome mortality. Evaluating with traditional methods, machine learning techniques have returns in progressing calculation activity. To enhance and maintain the medical assessment making procedure, a model was proposed for expecting a three-month healing outcome by examining the physiological considerations for the duration of 48 hours following stroke with logistic degeneration [39]. A database was observed with 107 patient’s medical information through acute anterior stroke and also posterior stroke via intra-arterial therapy [18]. Here, the data were examined through SVM and artificial neural network and achieved calculation accurateness of more than 70%. Machine learning procedures was used to recognize the control effect in brain arterio-venous abnormality satisfied with endo-vascular embolization. Though typical degeneration analysis representation could only reach a 43% precision rate, this technique’s exertion is much enhanced with 97.5% exactness. An optimal algorithm was analyzed to calculate 30 days mortality test and gained additional exact calculation than surviving techniques [40]. Likewise, SVM was used to calculate the stroke mortality via discharge. Additionally, the application of the synthetic alternative oversampling procedure was proposed to decrease the stroke effect calculation prejudice reasoned among class inequality between several datasets. Brain images were examined for calculating the effect of stroke cure. CT scan data were examined through machine learning procedure for estimating the cerebral edema through hemispheric infraction [41]. A random forest was constructed to involuntarily recognize the cerebrospinal fluid (CSF) and examined the changes in the CT scan, and this is more precise and capable compared to the traditional procedures. Functional connectivity was extracted from magnetic resonance imaging (MRI) and practical magnetic resonance imaging (MRI) data, and ridge degeneration and multitasking intellect were also applied for cognitive deficit calculation following stroke [42]. A relationship was examined, which involved injuries extorted from magnetic resonance imaging (MRI) and the cure effect through Gaussian method regression technique [43]. The model was used to calculate the difficulty of cognitive damages during stroke and the way of retrieval in due course. In Arterys Cardio DL process, where artificial intelligence (AI) is help to make available programmed and also changeable ventricle segmentations related on traditional MRI of cardiac images [44]. In nervous system disease, an artificial intelligence (AI) method was developed [45] for repairing the regulation of body movement in quadriplegia patients. Farina et al. experienced the control of the offline man–machine edge, which applies the release timings for the spinal motor neurons for controlling the prosthesis of the upper limb. IBM Watson for the oncology diagnosis can be a consistent AI for cancer diagnosis from start to the end, which was explained by Somashekhar et al. [46] by a double-blinded validation study. A clinical image was examined for recognizing skin cancer subtypes [20]. The applications of these three types’ diseases are not absolutely unpredicted. These three diseases are principal death causes; for that reason, analyzing the stages of the disease before time is vital to avoid worsening of the patients’ health condition. Moreover, quick diagnoses can prospectively reach throughout recovering the analysis measures on electrophysiological (EP) or electronic medical record (EMR), imaging and genetic, and this is the major power of the artificial intelligence (AI) technique. Moreover, apart from the three main diseases, artificial intelligence (AI) system has been used in another disease too: to examine the ocular image data for diagnosing inherited cataract diseases [19]. A referable diabetic retinopathy was detected by the retinal fundus photographs [21].
4. Application of artificial intelligence in modern medicine
Artificial intelligence in modern medicine and medial area has been a mostly upcoming hot topic in current years. Although there is wisdom of excessive prospective in the use of artificial intelligence in modern medicine, there are also worries about the defeat of the ‘human touch’ in such an important and person-motivated work. Artificial intelligence in modern medicine denotes to the practice of artificial intelligence tools and programmed procedures in the identification and cure of patients who need care. At the same time as analysis and cure may appear like modest phases, there are numerous other circumstantial procedures that come to pass in demand for a patient designate properly taken to attention, such as:
Collecting information data from patient discussions and checks
Treating and examining outcomes of result
Applying several causes of information data to derive an exact identification
Defining an applicable cure technique
Arranging and controlling the selected cure technique
Patient observing
Rehabilitation, continuation arrangements
Disagreement for enlarged use of artificial intelligence in modern medicine is that reasonably a various of the beyond could be programmed—computerization often means jobs are finished more swiftly, and it also help to frees up the time of a medical expert’s when they could be acting other responsibilities, which cannot be computerized, and hence are appreciated as a more cherished practice of human wealth. For instance, technology application has improved in all regions of daily life. Now, there are unbelievable volumes of tools and robotics in association with modern medicine; all medical information is digitized, online appointments can be arranged, and with the help of different healthcare apps in smartphone, it can be easy to find out nearest medical clinics or any health centers. Artificial intelligence is already being used in healthcare modern medicine nowadays. As a medical assessment support system, DXplain [47] is an artificial intelligence system that can help to perform on a set of medical outcomes like symptoms, marks, laboratory files, etc. to make a hierarchical list of identification that can describe the medical indices. Germwatcher [48] is another artificial intelligent system that is considered to notice, and examine taints in needy patients. In medical robotic surgical technology, the “da Vinci robotic surgical system” [49] with defined movement, robotic arms, and magnetized visualization permits surgeons to perform surgery that is not possible through an exclusively manual method. The probable for enlarged artificial intelligence practice in modern medicine is not objective in a decrease of physical jobs and reducing doctor’s time, growing proficiency and output-it also offers the prospect for healthcare system to change to further accuracy of modern medicine.
5. Alginate and AI in biomedical fields
Smart biomedical and medical packaging with the application of polymers is a generally and rapidly growing area of interest for academia and industries. Among a variety of polymers such as alginate, many uses have been created such as in biomedical field, medicine, packaging, and food sector [50]. For example, in modern drug delivery systems, a mesh completed of nanofibers created by the electro-spinning process is highly desired. Electro-spinning for biomedicine is based on the application of natural substances and biopolymers, along with the mixture of drugs such as sulfisoxazole, naproxen, and essential oils with antibacterial properties such as eugenol and tocopherol. In recent times, there has been an enormous thrust in the usage of biopolymers for a number of applications, especially in the biomedical and also in pharmaceutical areas [51, 52]. The functional effectiveness of the biopolymer molecules depends on the physicochemical properties, structural features, and composition [53]. It is feasible to rationally design the structure and composition of the biopolymer to gain suitable useful features [54]. The internal structure of the polymer molecule determines many functional characteristics, for example permeability, integrity, and chargeability [55]. The strength of the biopolymer particles and their summative capability is influenced by the electrical characteristics. Molecules of biopolymers and their electrical properties influence the contact with other molecules present in the neighboring environment. Alginate is one of the most popular natural biopolymers and intensely studied [56, 57]. It is an anionic biopolymer consisting of units of guluronic acid and mannuronic acid in uneven blocks [58]. Guluronic acid and mannuronic acid are linked by glycosidic linkages [59, 60], whereas the guluronic acid forms α bonds (1 → 4) and β (1 → 4) bonds with mannuronic acid [61]. The stiffness of molecular chains is ensured by the rigid and bent conformations of guluronic acid [62]. Hecth et al. have recently discussed their study on the characterization of calcium alginate and sodium alginate with particular importance on their structure [63]. Different applications and properties of alginate have also been examined. Alginate characteristics used biomedical especially in biomedicine can be formed by adjusting the accessibility of their hydroxyl and carboxyl groups [64]. It influences the characteristics of alginates, such as hydrophobicity, solubility, and their biological activity [65]. Alginate hydrogels were formed by cross-linking polymer chains [66]. The chemical properties of alginate hydrogels were found to depend on the cross-linking density of the chain [67]. The cellular viability of MG-63 osteosarcoma cells was improved by blending alginate bioink solution with N-acetyl cysteine (NAC) [68]. One of the techniques used in the design of alginate hydrogels is intermolecular cross-linking, wherein only the alginate guluronan groups react with the divalent cation, most frequently the calcium used to gel the alginate [69].
6. Conclusions
Artificial intelligence (AI) in healthcare offered a variety of healthcare information results that artificial intelligence (AI) has examined and reviewed the most important types of diseases that artificial intelligence (AI) has arranged. Machine learning (ML) and natural language processing are two major groups of artificial intelligence (AI) devices. For machine learning (ML) process, two most accepted traditional methods are available, that is, neural network and SVM. A typical artificial intelligence (AI) system must have the machine learning (ML) component that can help for conducting the structured data such as EP data, images, and genetic data and another natural language processing (NLP) module for the deduction of unstructured works. The complicated algorithm requires to be taught during the healthcare results previous to the system which can support the physicians for the disease analysis and plans which should be required for treatment. This technique focuses on how computer-oriented assessment methods, within the same roof as artificial intelligence (AI), can help in improving health and clinical area. Even though sophisticated information and machine learning present the base for artificial intelligence (AI), at present, there are revolutionary progresses happening in the subfield of neural networks. This has produced remarkable enthusiasm in several fields of healthcare science, as well as drug analysis and public health. Deep neural networks can execute as well as the most excellent human clinicians in definite diagnostic responsibilities. Additionally, artificial intelligence (AI) tools are already emerging in health-based apps, which can be engaged in handheld, network machines such as smart mobile phones. The major obstructions to be defeated in building health and healthcare data information are the space between digital data and human cognition. Data information regarding an entity patient is mostly gained in forms designed to be available to healthcare personnel. Typical data may consist of MRI or X-ray or ultrasound pictures of the patient, visual records of lung or heart function differing with time, or verbal similes of the patient as seen by the medical personnel. Alternatively, when data are accumulated in data information process and applied, in health research or to expand treatment procedures, it is regularly concentrated to statistical information that is mainly digital. The transfer of analog input into digital output is an oppressive task and may result in a defeat of important information, which would have been cooperative to the consumer.
\n',keywords:"artificial intelligence (AI), machine learning (ML), natural language processing (NLP), medical imaging, SVM",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/70446.pdf",chapterXML:"https://mts.intechopen.com/source/xml/70446.xml",downloadPdfUrl:"/chapter/pdf-download/70446",previewPdfUrl:"/chapter/pdf-preview/70446",totalDownloads:1680,totalViews:0,totalCrossrefCites:10,dateSubmitted:"September 20th 2019",dateReviewed:"November 11th 2019",datePrePublished:"December 12th 2019",datePublished:"February 5th 2020",dateFinished:"December 12th 2019",readingETA:"0",abstract:"Artificial intelligence (AI) has the potential of detecting significant interactions in a dataset and also it is widely used in several clinical conditions to expect the results, treat, and diagnose. Artificial intelligence (AI) is being used or trialed for a variety of healthcare and research purposes, including detection of disease, management of chronic conditions, delivery of health services, and drug discovery. In this chapter, we will discuss the application of artificial intelligence (AI) in modern healthcare system and the challenges of this system in detail. Different types of artificial intelligence devices are described in this chapter with the help of working mechanism discussion. Alginate, a naturally available polymer found in the cell wall of the brown algae, is used in tissue engineering because of its biocompatibility, low cost, and easy gelation. It is composed of α-L-guluronic and β-D-manuronic acid. To improve the cell-material interaction and erratic degradation, alginate is blended with other polymers. Here, we discuss the relationship of artificial intelligence with alginate in tissue engineering fields.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/70446",risUrl:"/chapter/ris/70446",signatures:"Sudipto Datta, Ranjit Barua and Jonali Das",book:{id:"8019",type:"book",title:"Alginates",subtitle:"Recent Uses of This Natural Polymer",fullTitle:"Alginates - Recent Uses of This Natural Polymer",slug:"alginates-recent-uses-of-this-natural-polymer",publishedDate:"February 5th 2020",bookSignature:"Leonel Pereira",coverURL:"https://cdn.intechopen.com/books/images_new/8019.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-78985-642-2",printIsbn:"978-1-78985-641-5",pdfIsbn:"978-1-83968-558-3",isAvailableForWebshopOrdering:!0,editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"304764",title:"Dr.",name:"Sudipto",middleName:null,surname:"Datta",fullName:"Sudipto Datta",slug:"sudipto-datta",email:"dattadip440v@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Artificial intelligence (AI) devices",level:"1"},{id:"sec_2_2",title:"2.1 Machine learning (ML) processes",level:"2"},{id:"sec_3_2",title:"2.2 Neural network",level:"2"},{id:"sec_4_2",title:"2.3 The support vector machine (SVM)",level:"2"},{id:"sec_5_2",title:"2.4 Deep learning method",level:"2"},{id:"sec_6_2",title:"2.5 Natural language processing",level:"2"},{id:"sec_8",title:"3. Artificial intelligence (AI) applications in healthcare system",level:"1"},{id:"sec_9",title:"4. Application of artificial intelligence in modern medicine",level:"1"},{id:"sec_10",title:"5. Alginate and AI in biomedical fields",level:"1"},{id:"sec_11",title:"6. Conclusions",level:"1"}],chapterReferences:[{id:"B1",body:'James G, Witten D, Hastie T, et al. An Introduction to Statistical Learning with Applications in R. 1st ed. Springer; 2013'},{id:"B2",body:'Darcy AM, Louie AK, Roberts LW. Machine learning and the profession of medicine. JAMA. 2016;315:551-552'},{id:"B3",body:'Christopher DM, Hinrich S. Foundations of Statistical Natural Language Processing. Cambridge, London, England: The MIT Press; 1999'},{id:"B4",body:'Murff HJ, FitzHenry F, Matheny ME, et al. Automated identification of postoperative complications within an electronic medical record using natural language processing. JAMA. 2011;306:848-855'},{id:"B5",body:'Good fellow I, Bengio Y, Courville A. Deep Learning. 1st ed. Cambridge, London, England: The MIT Press; 2016'},{id:"B6",body:'Mirtskhulava L, Wong J, Al-Majeed S, Pearce G, et al., editors. Artificial neural network model in stroke diagnosis. In: 2015 17th UKSim-AMSS International Conference on Modelling and Simulation (UKSim). IEEE; 2015'},{id:"B7",body:'Bishop CM, editor. Pattern Recognition and Machine Learning (Information Science and Statistics); 2007'},{id:"B8",body:'Khan J, Wei JS, Ringnér M, et al. Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nature Medicine. 2001;7:673-679'},{id:"B9",body:'Dheeba J, Albert Singh N, Tamil Selvi S. Computer-aided detection of breast cancer on mammograms: A swarm intelligence optimized wavelet neural network approach. Journal of Biomedical Informatics. 2014;49:45-52'},{id:"B10",body:'Hirschauer TJ, Adeli H, Buford JA. Computer-aided diagnosis of Parkinson’s disease using enhanced probabilistic neural network. Journal of Medical Systems. 2015;39:179'},{id:"B11",body:'Orrù G, Pettersson-Yeo W, Marquand AF, et al. Using support vector machine to identify imaging biomarkers of neurological and psychiatric disease: A critical review. Neuroscience & Biobehavioral Reviews. 2012;36:1140-1152'},{id:"B12",body:'Sweilam NH, Tharwat AA, Abdel Moniem NK, Moniem NKA. Supportvector machine for diagnosis cancer disease: A comparative study. Egyptian Informatics Journal. 2010;11:81-92'},{id:"B13",body:'Khedher L, Ramírez J, Górriz JM, et al. Early diagnosis of Alzheimer’s disease based on partial least squares, principal component analysis and support vector machine using segmented MRI images. Neurocomputing. 2015;151:139-150'},{id:"B14",body:'Farina D, Vujaklija I, Sartori M, et al. Man/machine interface based on the discharge timings of spinal motor neurons after targeted musclere innervation. Nature Biomedical Engineering. 2017;1:0025'},{id:"B15",body:'Ravi D, Wong C, Deligianni F, et al. Deep learning for health informatics. IEEE Journal of Biomedical and Health Informatics. 2017;21:4-21'},{id:"B16",body:'Lecun Y, Bottou L, Bengio Y, et al. Gradient-based learning applied to document recognition. Proceedings of the IEEE (Inst Electr Electron Eng). 1998;86:2278-2324'},{id:"B17",body:'Research BA. Caffe. 2017. Available from: http://caffe.berkeleyvision.org/ [Accessed: 1 June 2017]'},{id:"B18",body:'Abadi M, Agarwal A, Barham P, et al; Tensor Flow: Large-Scale Machine Learning on Heterogeneous Distributed Systems; 2016'},{id:"B19",body:'Long E, Lin H, Liu Z, et al. An Artificial Intelligence Platform for the Multihospital Collaborative Management of Congenital Cataracts; 2017'},{id:"B20",body:'Esteva A, Kuprel B, Novoa RA, et al. Dermatologist-level classification of skin cancer with deep neural networks. Nature. 2017;542:115-118'},{id:"B21",body:'Gulshan V, Peng L, Coram M, et al. Development and validation of deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA. 2016;316:2402-2410'},{id:"B22",body:'Afzal N, Sohn S, Abram S, et al. Mining peripheral arterial disease cases from narrative clinical notes using natural language processing. Journal of Vascular Surgery. 2017;65:1753-1761'},{id:"B23",body:'Fiszman M, Chapman WW, Aronsky D, et al. Automatic detectionof acute bacterial pneumonia from chest X-ray reports. Journal of the American Medical Informatics Association. 2000;7:593-604'},{id:"B24",body:'Miller TP, Li Y, Getz KD, et al. Using electronic medical record data toreport laboratory adverse events. British Journal of Haematology. 2017;177:283-286'},{id:"B25",body:'Castro VM, Dligach D, Finan S, et al. Large-scale identification of patients with cerebral aneurysms using natural language processing. Neurology. 2017;88:164-168'},{id:"B26",body:'Dilsizian SE, Siegel EL. Artificial intelligence in medicine and cardiac imaging: Harnessing big data and advanced computing to provide personalized medical diagnosis and treatment. Current Cardiology Reports. 2014;16:441'},{id:"B27",body:'Saenger AK, Christenson RH. Stroke biomarkers: Progress and challenges for diagnosis, prognosis, differentiation, and treatment. Clinical Chemistry. 2010;56:21-33'},{id:"B28",body:'Heeley E, Anderson CS, Huang Y, et al. Role of health insurance inverting economic hardship in families after acute stroke in China. Stroke. 2009;40:2149-2156'},{id:"B29",body:'Villar JR, González S, Sedano J, et al. Improving human activity recognition and its application in early stroke diagnosis. International Journal of Neural Systems. 2015;25:1450036'},{id:"B30",body:'Mannini A, Trojaniello D, Cereatti A, et al. A machine learning framework for gait classification using inertial sensors: Application to elderly, post-stroke and Huntington’s disease patients. Sensors. 2016;16:134'},{id:"B31",body:'Rehme AK, Volz LJ, Feis DL, et al. Identifying neuroimaging markers of motor disability in acute stroke by machine learning techniques. Cerebral Cortex. 2015;25:3046-3056'},{id:"B32",body:'Griffis JC, Allendorfer JB, Szaflarski JP. Voxel-based Gaussian naïve Bayes classification of ischemic stroke lesions in individual T1-weighted MRI scans. Journal of Neuroscience Methods. 2016;257:97-108'},{id:"B33",body:'Kamnitsas K, Ledig C, Newcombe VF, et al. Efficient multi-scale3D CNN with fully connected CRF for accurate brain lesion segmentation. Medical Image Analysis. 2017;36:61-78'},{id:"B34",body:'Rondina JM, Filippone M, Girolami M, et al. Decoding post-stroke motor function from structural brain imaging. NeuroImage: Clinical. 2016;12:372-380'},{id:"B35",body:'Thornhill RE, Lum C, Jaberi A, et al. Can shape analysis differentiate free-floating internal carotid artery Thrombus from atherosclerotic plaque in patients evaluated with CTA? For stroke or transient ischemic attack? Academic Radiology. 2014;21:345-354'},{id:"B36",body:'Bentley P, Ganesalingam J, Carlton Jones AL, et al. Prediction of stroke thrombolysis outcome using CT brain machine learning. NeuroImage: Clinical. 2014;4:635-640'},{id:"B37",body:'Love A, Arnold CW, El-Saden S, et al. Unifying acute stroke treatment guidelines for a bayesian belief network. Studies in Health Technology and Informatics. 2013;192:1012'},{id:"B38",body:'Ye H, Shen H, Dong Y, et al. Using Evidence-Based Medicine through Advanced Data Analytics to Work toward a National Standard for Hospital-Based Acute Ischemic Stroke Treatment. Mainland China; 2017'},{id:"B39",body:'Zhang Q , Xie Y, Ye P, et al. Acute ischaemic stroke prediction from physiological time series patterns. The Australasian Medical Journal. 2013;6:280-286'},{id:"B40",body:'Birkner MD, Kalantri S, Solao V, et al. Creating diagnostic scores using data-adaptive regression: An application to prediction of 30-day mortality among stroke victims in a rural hospital in India. Therapeutics and Clinical Risk Management. 2007;3:475-484'},{id:"B41",body:'Chen Y, Dhar R, Heitsch L, et al. Automated quantification of cerebral edema following hemispheric infarction: Application of a machine learning algorithm to evaluate CSF shifts on serial head CTs. NeuroImage: Clinical. 2016;12:673-680'},{id:"B42",body:'Siegel JS, Ramsey LE, Snyder AZ, et al. Disruptions of network connectivity predict impairment in multiple behavioral domains after stroke. Proceedings of the National Academy of Sciences of the United States of America. 2016;113:E4367-E4376'},{id:"B43",body:'Hope TM, Seghier ML, Leff AP, et al. Predicting outcome and recovery after stroke with lesions extracted from MRI images. NeuroImage: Clinical. 2013;2:424-433'},{id:"B44",body:'Marr B. First FDA Approval for Clinical Cloud-Based Deep Learning in Healthcare; 2017'},{id:"B45",body:'Bouton CE, Shaikhouni A, Annetta NV, et al. Restoring cortical control of functional movement in a human with quadriplegia. Nature. 2016;533:247-250'},{id:"B46",body:'Somashekhar SP, Kumarc R, Rauthan A. Abstract S6-07: Double blinded validation study to assess performance of IBM artificial intelligence platform, Watson for oncology in comparison with manipal multidisciplinary tumourboard? First study of 638 breast cancer cases. Cancer Research. 2017;77(4 Suppl):S6-S7'},{id:"B47",body:'Barnett GO, Cimino JJ, Hupp JA, Hoffer EP. DXplain. An evolving diagnostic decision-support system. The Journal of the American Medical Association. 1987;258(1):67-74'},{id:"B48",body:'Khan MG, Steib SA, Dunagan WC, Fraser VJ. Monitoring expert system performance using continuous user feedback. Journal of the American Medical Informatics Association. 1996;3:216-223'},{id:"B49",body:'Rao R, Nayyar R, Panda S, Hemal AK. Surgical techniques: Robotic bladder diverticulectomy with the da Vinci-S surgical system. Journal of Robotic Surgery. 2007;1:217-220'},{id:"B50",body:'Barua R, Datta S, Datta P, RoyChowdhury A. Scaffold and Tissue Engineering Applications by 3D Bio-Printing Process: A New Approach. IgI Global; 2019. pp. 78-99'},{id:"B51",body:'Fernando IPS, Kim D, Nah J-W, Jeon Y-J. Advances in functionalizing fucoidans and alginates (bio) polymers by structural modifications: A review. 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UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
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The model parameters deciphered here are the amplitude coefficient (k), horizontal location (x0), depth of the body (z), and shape (q). Inversion of the model parameter suggests that constraining the horizontal location and the shape factor offers the most reliable results. Investigation of convergence rate, histogram, and cross-plot examination suggest that the interpretation method developed for the self-potential anomalies is stable and the model parameters are within the estimated ambiguity. Inversion of synthetic noise-free and noise-corrupted data for single structures and multiple structures in addition to real field information exhibits the viability of the method. The model parameters estimated by the present technique were in good agreement with the real parameters. The method has been used to invert two field examples (Sulleymonkoy anomaly, Ergani, Turkey, Senneterre area of Quebec, Canada) with application of subsurface mineralized bodies. 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In fact, under some specific conditions the NCMs could be used either as effective adsorbent material or alternative source of minerals. This chapter presents an outline of a general review of factors that affect the application ability of NCMs and a descriptive analysis of NH4+ and REE adsorption behavior and extraction of rare earth elements (REE) by an ion-exchange with NH4+ ions onto NCMs. Clays and NCMs both effectively remove various contaminants from aqueous solution and serve as alternative sources of minerals, as extensively discussed in this chapter. This review compiles thorough literature of current research and highlights the key findings of adsorption (NH4+ and REE) that use different NCMs as adsorbents or alternative sources of minerals (i.e., REE). The review confirmed that NCMs excellently remove different cations pollutants and have significant potential as alternative source of REE. However, modification and further development of NCMs applications for getting the best adsorption and the best extraction of REE onto NCMs, which would enhance pollution control and leaching system is still needed.",book:{id:"7315",slug:"minerals",title:"Minerals",fullTitle:"Minerals"},signatures:"Aref Alshameri, Xinghu Wei, Hailong Wang, Yang Fuguo, Xin Chen, Hongping He, Chunjie Yan and Feng Xu",authors:[{id:"172947",title:"Prof.",name:"Xin",middleName:null,surname:"Chen",slug:"xin-chen",fullName:"Xin Chen"},{id:"250327",title:"Dr.",name:"Aref",middleName:null,surname:"Alshameri",slug:"aref-alshameri",fullName:"Aref Alshameri"},{id:"306625",title:"Dr.",name:"Aref",middleName:null,surname:"Alshameri",slug:"aref-alshameri",fullName:"Aref Alshameri"},{id:"306656",title:"Prof.",name:"Fuguo",middleName:null,surname:"Yang",slug:"fuguo-yang",fullName:"Fuguo Yang"},{id:"306658",title:"Dr.",name:"Wei",middleName:null,surname:"Xinghu",slug:"wei-xinghu",fullName:"Wei Xinghu"},{id:"306660",title:"Prof.",name:"Wang",middleName:null,surname:"Hailong",slug:"wang-hailong",fullName:"Wang Hailong"},{id:"306664",title:"Prof.",name:"Yan",middleName:null,surname:"Chunjie",slug:"yan-chunjie",fullName:"Yan Chunjie"},{id:"306665",title:"Dr.",name:"Xu",middleName:null,surname:"Feng",slug:"xu-feng",fullName:"Xu Feng"},{id:"306671",title:"Prof.",name:"He",middleName:null,surname:"Hongping",slug:"he-hongping",fullName:"He Hongping"}]}],mostDownloadedChaptersLast30Days:[{id:"71052",title:"Enhanced Humidity Sensing Response in Eu3+-Doped Iron-Rich CuFe2O4: A Detailed Study of Structural, Microstructural, Sensing, and Dielectric Properties",slug:"enhanced-humidity-sensing-response-in-eu-sup-3-sup-doped-iron-rich-cufe-sub-2-sub-o-sub-4-sub-a-deta",totalDownloads:596,totalCrossrefCites:7,totalDimensionsCites:7,abstract:"The CuFe(2−x)EuxO4 (where x = 0.00, 0.01, 0.02, 0.03) nanoparticles are synthesized by solution combustion method. The influence of Eu3+ on the structural, morphological, dielectrical, and humidity sensing study is recorded. The XRD pattern peaks of the as-prepared CuFe(2−x)EuxO4 (where x = 0.00, 0.01, 0.02, 0.03) nanoparticle confirm the polycrystalline spinel cubic structure with a small amount of CuO impurity phase at 38.87° and 48.96°. Surface morphology of the samples was studied by scanning electron microscope (SEM) images of the nanoparticles, and their respective average grain size was estimated using Image software. Chemical composition of all prepared samples was analyzed by EDS spectra. The dielectric parameters of AC conductivity, electric modulus, and impedance of the samples were measured over a range of frequencies from 0.1 KHz to 1 MHz at room temperature. Europium-doped copper ferrite samples showed good humidity sensing response, response and recover times, and stability over a %RH range of 11–91%. These types of samples are very useful for sensor application, battery applications, electronic applications, and automotive applications.",book:{id:"9247",slug:"mineralogy-significance-and-applications",title:"Mineralogy",fullTitle:"Mineralogy - Significance and Applications"},signatures:"I.C. Sathisha, K. Manjunatha, V. Jagadeesha Angadi, B. Chethan, Y.T. Ravikiran, Vinayaka K. Pattar, S.O. Manjunatha and Shidaling Matteppanavar",authors:[{id:"266255",title:"Dr.",name:"Veerabhadrappa",middleName:null,surname:"Jagadeesha Angadi",slug:"veerabhadrappa-jagadeesha-angadi",fullName:"Veerabhadrappa Jagadeesha Angadi"},{id:"321561",title:"Dr.",name:"I.C.",middleName:null,surname:"Sathisha",slug:"i.c.-sathisha",fullName:"I.C. Sathisha"},{id:"321562",title:"Dr.",name:"K.",middleName:null,surname:"Manjunatha",slug:"k.-manjunatha",fullName:"K. Manjunatha"},{id:"321564",title:"Dr.",name:"B.",middleName:null,surname:"Chethan",slug:"b.-chethan",fullName:"B. Chethan"},{id:"321565",title:"Dr.",name:"Y.T.",middleName:null,surname:"Ravikiran",slug:"y.t.-ravikiran",fullName:"Y.T. Ravikiran"},{id:"321566",title:"Dr.",name:"Vinayaka K.",middleName:null,surname:"Pattar",slug:"vinayaka-k.-pattar",fullName:"Vinayaka K. Pattar"},{id:"321567",title:"Dr.",name:"S.O.",middleName:null,surname:"Manjunatha",slug:"s.o.-manjunatha",fullName:"S.O. Manjunatha"},{id:"321568",title:"Dr.",name:"Shidaling",middleName:null,surname:"Matteppanavar",slug:"shidaling-matteppanavar",fullName:"Shidaling Matteppanavar"}]},{id:"65826",title:"Introductory Chapter: Mineral Exploration from the Point of View of Geophysicists",slug:"introductory-chapter-mineral-exploration-from-the-point-of-view-of-geophysicists",totalDownloads:1635,totalCrossrefCites:3,totalDimensionsCites:3,abstract:null,book:{id:"7315",slug:"minerals",title:"Minerals",fullTitle:"Minerals"},signatures:"Khalid S. Essa and Marc Munschy",authors:[{id:"102766",title:"Prof.",name:"Khalid S.",middleName:null,surname:"Essa",slug:"khalid-s.-essa",fullName:"Khalid S. Essa"},{id:"292929",title:"Prof.",name:"Marc",middleName:null,surname:"Munschy",slug:"marc-munschy",fullName:"Marc Munschy"}]},{id:"69811",title:"Chemical Synthesis and Characterization of Luminescent Iron Oxide Nanoparticles and Their Biomedical Applications",slug:"chemical-synthesis-and-characterization-of-luminescent-iron-oxide-nanoparticles-and-their-biomedical",totalDownloads:564,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The syntheses and characterizations of biocompatible luminescent magnetic iron oxide nanoparticles has drawn particular attention as diagnostic and drug delivery tools for treatment of cancer and many other diseases. This chapter focuses on the chemical synthetic methods, magnetic and luminescent properties, including the biomedical applications of iron oxide nanomaterials and luminescent magnetic iron oxide-based nanocomposite materials. The influences of functionalizing with short ligands such as dopamine and L-cysteine on the magnetic properties of synthesized nanoparticles are described. The chapter contains some data on necessary reagents and protocols for bioconjugation aimed at cell culture and step by step the MTT assays used to evaluate cytotoxicity are also presented. In the final section of the chapter, we focus on the biomedical applications specifically for diagnosis and treatment of breast cancer treatment. This chapter also investigates the application of various characterization techniques for analysis of the structural, optical and magnetic properties of the iron oxide nanoparticles and as their nanocomposites.",book:{id:"9247",slug:"mineralogy-significance-and-applications",title:"Mineralogy",fullTitle:"Mineralogy - Significance and Applications"},signatures:"Martin Onani, Leandre Brandt and Zuraan Paulsen",authors:[{id:"258023",title:"Dr.",name:"Martin",middleName:null,surname:"Onani",slug:"martin-onani",fullName:"Martin Onani"},{id:"302723",title:"Dr.",name:"Leandré Bianca",middleName:null,surname:"Brandt",slug:"leandre-bianca-brandt",fullName:"Leandré Bianca Brandt"},{id:"302725",title:"MSc.",name:"Zuraan",middleName:null,surname:"Paulsen",slug:"zuraan-paulsen",fullName:"Zuraan Paulsen"}]},{id:"27429",title:"An Introduction to Mineralogy",slug:"an-introduction-to-mineralogy",totalDownloads:6621,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"1600",slug:"an-introduction-to-the-study-of-mineralogy",title:"An Introduction to the Study of Mineralogy",fullTitle:"An Introduction to the Study of Mineralogy"},signatures:"Cumhur Aydinalp",authors:[{id:"98959",title:"Prof.",name:"Cumhur",middleName:"---",surname:"Aydinalp",slug:"cumhur-aydinalp",fullName:"Cumhur Aydinalp"}]},{id:"27435",title:"A Review of Pathological Biomineral Analysis Techniques and Classification Schemes",slug:"a-review-of-pathological-biomineral-analysis-techniques-and-classification-schemes",totalDownloads:4303,totalCrossrefCites:1,totalDimensionsCites:6,abstract:null,book:{id:"1600",slug:"an-introduction-to-the-study-of-mineralogy",title:"An Introduction to the Study of Mineralogy",fullTitle:"An Introduction to the Study of Mineralogy"},signatures:"Maria Luigia Giannossi and Vito Summa",authors:[{id:"101919",title:"PhD.",name:"Maria Luigia",middleName:null,surname:"Giannossi",slug:"maria-luigia-giannossi",fullName:"Maria Luigia Giannossi"},{id:"108348",title:"Dr.",name:"Vito",middleName:null,surname:"Summa",slug:"vito-summa",fullName:"Vito Summa"}]}],onlineFirstChaptersFilter:{topicId:"651",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81626",title:"Use of Natural Safiot Clay for the Removal of Chemical Substances from Aqueous Solutions by Adsorption: A Combined Experimental and Theoretical Study",slug:"use-of-natural-safiot-clay-for-the-removal-of-chemical-substances-from-aqueous-solutions-by-adsorpti",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.101605",abstract:"The main objective of this work was to investigate the potential of Natural Safiot Clay (NSC), as an adsorbent for the removal of two cationic dyes such as Basic Blue 9 (BB9) and Basic Yellow 28 (BY28) from single and binary systems in aqueous solutions. For this, the effects of three factors controlling the adsorption process, such as initial dye concentration, adsorbent dose, and initial pH on the adsorption extent, were investigated and examined. The natural safiot clay was characterized using the following technique: energy-dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), DRX, and Fourier transform infrared (FT-IR) and pH of the point of zero charge (pHZPC). Energy-dispersive X-ray spectroscopy results indicate high percentages of Silica and Alumina. FT-IR spectrum identified kaolinite as the major mineral phase in the presence of quartz, calcite, and dolomite. The quantum theoretical study confirms the experimental results, through the study of the global and local reactivity and the electrophilicity power of the dyes. The electrophilicity power of dyes affects the removal efficiency. The theoretical study proves that BB9 (ω = 6.178) is more electrophilic than BY28 (ω = 2.480) and more interactions with surface sites. The results of the molecular dynamics simulation indicate that the dyes are adsorbed parallel to the surface of natural Safi clay (kaolinite), implying the strong interaction with the kaolinite atoms. All the results of quantum chemistry calculations and simulations of molecular dynamics are in perfect agreement with the results of the experimental study.",book:{id:"11137",title:"Mineralogy",coverURL:"https://cdn.intechopen.com/books/images_new/11137.jpg"},signatures:"Aziz El Kassimi, Mohammadine El Haddad, Rachid Laamari, Mamoune El Himri, Youness Achour and Hicham Yazid"},{id:"80866",title:"Normative Mineralogy Especially for Shales, Slates, and Phyllites",slug:"normative-mineralogy-especially-for-shales-slates-and-phyllites",totalDownloads:44,totalDimensionsCites:0,doi:"10.5772/intechopen.102346",abstract:"First, an insight into normative mineralogy and the most important methods for calculating the standard or norm minerals, such as the CIPW norm, is given. This is followed by a more detailed explanation of “slatenorm” and “slatecalculation” for low and very low metamorphic rocks, such as phyllites, slates, and shales. They are particularly suitable for fine-grained rocks where the mineral content is difficult to determine. They enable the determination of a virtual mineral inventory from full chemical analysis, including the values of carbon dioxide (CO2), carbon (C), and sulfur (S). The determined norm or standard minerals include the minerals—feldspars, carbonates, micas, hydro-micas, chlorites, ore minerals, and quartz. The advantages of slatenorm and slatecalculation compared to other methods for calculating normal minerals of sedimentary rocks are discussed.",book:{id:"11137",title:"Mineralogy",coverURL:"https://cdn.intechopen.com/books/images_new/11137.jpg"},signatures:"Hans Wolfgang Wagner"},{id:"80770",title:"Mg-Ilmenite from Kimberlites, Its Origin",slug:"mg-ilmenite-from-kimberlites-its-origin",totalDownloads:57,totalDimensionsCites:0,doi:"10.5772/intechopen.102676",abstract:"The main regularities of the saturation of kimberlite rocks with the accessory mineral Mg-ilmenite (Ilm), the peculiarities of the distribution of Ilm compositions in individual pipes, in different clusters of pipes, in diamondiferous kimberlite fields, are considered as the example of studies carried out within the Yakutian kimberlite province (Siberian Craton). Interpretation of different crystallization trends in MgO-Cr2O3 coordinates (conventionally named “Haggerty’s parabola”, “Steplike”, “Hockey stick”, as well as the peculiarities of heterogeneity of individual zonal and polygranular Ilm macrocrysts made it possible to propose a three-stage model of crystallization Ilm: (1) Mg-Cr poor ilmenite crystallizing from a primitive asthenospheric melt; (2) Continuing crystallization in the lithospheric contaminated melt by MgO and Cr2O3; (3) Ilmenite subsequently underwent sub-solidus recrystallization in the presence of an evolved kimberlite melt under increasing oxygen fugacity (ƒO2) conditions.",book:{id:"11137",title:"Mineralogy",coverURL:"https://cdn.intechopen.com/books/images_new/11137.jpg"},signatures:"Sergey I. Kostrovitsky"},{id:"80553",title:"Investigation of Accessory Minerals from the Blatná Granodiorite Suite, Bohemian Massif, Czech Republic",slug:"investigation-of-accessory-minerals-from-the-blatn-granodiorite-suite-bohemian-massif-czech-republic",totalDownloads:48,totalDimensionsCites:0,doi:"10.5772/intechopen.102628",abstract:"The Central Bohemian magmatic complex belongs to the Central European Variscan belt. The granitic rocks of this plutonic complex are formed by several suites of granites, granodiorites, and tonalites, together with small bodies of gabbros, gabbro diorites, and diorites. The granodiorites of the Blatná suite are high-K, calc-alkaline to shoshonitic, and metaluminous to slightly peraluminous granitic rocks. Compared to the common I-type granites, granodiorites of the Blatná suite are enriched in Mg (1.0–3.4 wt.% MgO), Ba (838–2560 ppm), Sr. (257–506 ppm), and Zr (81–236 ppm). For granodiorites of the Blatná suite is assemblage of apatite, zircon, titanite, and allanite significant. Zircon contains low Hf concentrations (1.1–1.7 wt.% HfO2). The composition of titanite ranges from 83 to 92 mol.% titanite end-member. Allanite is relatively Al-poor and displays Feox. ratio 0.2–0.5.",book:{id:"11137",title:"Mineralogy",coverURL:"https://cdn.intechopen.com/books/images_new/11137.jpg"},signatures:"Miloš René"},{id:"80423",title:"Minerals as Prebiotic Catalysts for Chemical Evolution towards the Origin of Life",slug:"minerals-as-prebiotic-catalysts-for-chemical-evolution-towards-the-origin-of-life",totalDownloads:106,totalDimensionsCites:0,doi:"10.5772/intechopen.102389",abstract:"A transition from geochemistry to biochemistry has been considered as a necessary step towards the emergence of primordial life. Nevertheless, how did this transition occur is still elusive. The chemistry underlying this transition is likely not a single event, but involves many levels of creation and reconstruction, finally reaching the molecular, structural, and functional buildup of complexity. Among them, one apparent question is: how the biochemical catalytic system emerged from the mineral-based geochemical system? Inspired by the metal–ligand structures in metalloenzymes, many researchers have proposed that transition metal sulfide minerals could have served as structural analogs of metalloenzymes for catalyzing prebiotic redox conversions. This assumption has been tested and verified to some extent by several studies, which focused on using Earth-abundant transition metal sulfides as catalysts for multi-electron C and N conversions. The progress in this field will be introduced, with a focus on the CO2 fixation and ammonia synthesis from nitrate/nitrite reduction and N2 reduction. Recently developed methods for screening effective mineral catalysts were also reviewed.",book:{id:"11137",title:"Mineralogy",coverURL:"https://cdn.intechopen.com/books/images_new/11137.jpg"},signatures:"Yamei Li"},{id:"80338",title:"Ionic Conductivity of Strontium Fluoroapatites Co-doped with Lanthanides",slug:"ionic-conductivity-of-strontium-fluoroapatites-co-doped-with-lanthanides",totalDownloads:54,totalDimensionsCites:0,doi:"10.5772/intechopen.102410",abstract:"Britholites derivatives of apatite’s that contain lanthanium and neodymium in the serial compounds Sr8La2−xNdx(PO4)4(SiO4)2F2 with 0 ≤ x ≤ 2 were subject of the present investigation. The solid state reaction was the route of preparing these materials. Several techniques were employed for the analysis and characterization of the synthesized powders. The chemical analysis results indicated that molar ratio Sr+La+NdP+Si was of about 1.67 value of a stoichiometric powder. The X-ray diffraction data showed single-phase apatites crystallizing in hexagonal structure with P63/m space group were successively obtained. Moreover, the substitution of lanthanium by neodymium in strontium phosphosilicated fluorapatite was total. This was confirmed by the a and c lattice parameters contraction when (x) varies coherently to the sizes of the two cations. The infrared spectroscopy and the 31P NMR (MAS) exhibited the characteristic bands of phosphosilicated fluorapatite. The pressureless sintering of the material achieved a maximum of 89% relative density. The sintered specimens indicated that the Nd content as well as the heating temperature affected the ionic conduction of the materials and the maximum was 1.73 × 10−6 S cm−1 obtained at 1052 K for x = 2.",book:{id:"11137",title:"Mineralogy",coverURL:"https://cdn.intechopen.com/books/images_new/11137.jpg"},signatures:"Khouloud Kthiri, Mohammed Mehnaoui, Samira Jebahi, Khaled Boughzala and Mustapha Hidouri"}],onlineFirstChaptersTotal:10},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. 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Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. 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His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. 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He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. 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