\r\n\tThe planning and technology of the tunnel and underground structures is an important issue for building of the structure. Depending on the particulars of each project location and the construction time available, the adopted construction methods have an important influence on the success of the project. Traditional and novel methods are underlined with the focus on reliable and cost effective technology. \r\n\tOnce built, the tunnel needs to guarantee comfort to the users and reduce the risks of accident. The equipment is important to obtain adequate visibility and reduced concentration of contaminants. For these purposes, an adequate lighting system and ventilation system are necessary. Ventilation is also crucial in the case of emergency conditions, as it used to control fire development and smoke propagation. Operational and safety systems are to be analysed to fulfill the all the operational and emergency needs. The book investigates the relevant topics in these regards as the crucial point of tunnel exploitation. \r\n\tThe aim of the book in focused also on the aspect of the optimised maintenance strategy of tunnels that bases on a systematic condition assessment through the investigations. Operation and maintenance works in tunnels have an adverse effect on the traffic, hence it is essential to plan operation and maintenance works rationally and effectively as the maintenance have to minimise the impact on the daily traffic and to ensure cost effectiveness at all times.
",isbn:null,printIsbn:"979-953-307-X-X",pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"f640f0187c5c2db846fc350f222cb6a0",bookSignature:"Prof. Peter Vidmar",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/8538.jpg",keywords:"Planning of tunnels, Development of tunnel, Geomechanics, Investigation, Tunnel construction, Process monitoring, Tunnel installations, Technologies, Tunnel safety, Maintenance, Underground pipelines, Cables",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"August 30th 2019",dateEndSecondStepPublish:"September 20th 2019",dateEndThirdStepPublish:"November 19th 2019",dateEndFourthStepPublish:"February 7th 2020",dateEndFifthStepPublish:"April 7th 2020",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"69701",title:"Prof.",name:"Peter",middleName:null,surname:"Vidmar",slug:"peter-vidmar",fullName:"Peter Vidmar",profilePictureURL:"https://mts.intechopen.com/storage/users/69701/images/system/69701.jpeg",biography:"Peter Vidmar holds a PhD in Maritime and Transport science at Faculty of maritime studies and transportation, University of Ljubljana and a M. 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1. Introduction
Intrauterine devices (IUDs) represent long-lasting reversible birth control method [1] with the greatest satisfaction among users [2]. However, this contraceptive use generated much heated discussion and debates, with exhaustive studies that are presented in the present chapter.
2. History of IUDs
Intrauterine contraception with various devices seems to have a long history, from the ancient Arabs who placed round smooth stones in the camels’ uteri to prevent conception during long journeys. In the late nineteenth century, intracervical devices have been used to prevent pregnancy or to induce abortion [3]. Still, the first medical communication on medical IUD was published in Germany, at the beginning of the twentieth century by Richter [4], who reported the results of intrauterine insertion of a metallic ring with catgut tied around it. In the 1920s, Ernest Graefenberg attached a silver wire to the ring for Roentgen visualization, but silver rings were rapidly abandoned as they led to gingival argyrosis. An alloy of copper, nickel, and zinc was used instead [5]. In 1959, the first paper was published who condemned the IUDs as dangerous because of the ineffectiveness, risk of infection, and carcinogenic potential [5]. The modern IUDs evolved from 1960 with a T-shaped product that configured better to the natural shape of the uterus [6]. By the mid-1960s, IUDs became a widely used method with fewer potential cardiovascular risks when compared to oral contraceptives [7]. In 1970, nearly 10% of women were using the Dalkon Shield IUD as a contraceptive method. Since then, the use of IUDs dropped because of the severe septic cases reported, along with the increased risk of pelvic inflammatory disease (PID) and infertility [8]. IUDs were even withdrawn from the US market between 1986 and 1988.
Since the introduction of the levonorgestrel 52 mg IUD in 2001, this intervention achieved a new, therapeutic, dimension—because of significant benefits in treating heavy menstrual bleeding and dysmenorrhea [7].
Today, IUDs are an important component of family planning, as they are used by one in 10 women in the USA and 9–24% of all contraceptives in European countries [9]. The highest rates of IUD use are recorded in Asia: 40% of women in China, 50% in Korea, and 56% in Uzbekistan [10], while the lowest rates are recorded in Africa. The trend of contraceptive method is declining as the use of injectable products is increasing [11]. From the beginning, the gynecologists were preferred for a safe insertion of the IUD, instead of general practitioners [3].
3. Types of IUDs: copper and hormonal
The two main types of IUDs are the copper non-hormonal device and the hormonal device.
There are a few types of copper devices as well. The most frequent copper device series are the T380 devices that also consist of the original T380A, the T380Ag available in Finland, and the T380S available in Canada and UK [12]. This IUD has a small plastic “T” frame with a stem wrapped with copper wire and also copper collars on the two arms of the frame, of about 380 mm2 of copper. T380A has been approved around the world for up to 10 years [13], with no uterine perforation reported, but a high rate of medical removal due to bleeding, pain, and pelvic infection [12].
Other types of copper IUDs include the Multiload series of devices that consists of ML250 for a 3 years’ use and the ML375 with more copper to enhance a longer use, up to 5 years. The device has additional plastic fins on the lateral, and curved arms to avoid spontaneous expulsion [12].
The GyneFix device has been introduced in 1997 as a frameless copper-bearing device designed especially for nulliparous women. However, it associates an increased risk of expulsion in the first 3 months. Both GyneFix and T380A are reported to have high efficiency in women contraception [14].
Besides pure copper devices, there is also a gold IUD called Eurogine Gold T, Goldlily, or GoldringMedusa, with a gold core that prevents the copper from fragmenting or corroding [15].
Silver was also being added on a copper device, to reduce fragmentation, and to prolong the lifespan of the device. The production of the initial NovaT200 was ceased, because of poorer performance and NovaT 380 was developed [12].
To reduce side effects of IUDs such as bleeding, pain, and expulsion, Flexi-T300 was introduced, with a smaller and more flexible frame and thinner side arms that are bent back on themselves. Flexi-T300 is also preferred for emergency contraception, as it is cheap and easily inserted and removed [12].
Since 1976, medicated or hormonal IUDs were developed. Mirena was produced in 2001 as a hormonal IUD releasing 52 mg of levonorgestrel during a 5 years’ period of approved use [7]. Mirena releases approximately 20 μg of levonorgestrel daily in the first few weeks with a decrease to 18 μg/day by the end of 1 year and 10 μg/day after 5 years [16]. Other hormonal IUDs, as Skyla or Jaydess, have a shorter period of use (3 years) because of the lower levonorgestrel content (13.5 mg), that is released 14 μg daily after the first few weeks and with a rapid decrease to 10 μg/day by 2 months and 5 μg/day by the end of 3 years [17]. Besides contraception, the hormonal IUDs reduce the blood flow with amenorrhea in about 20% of cases within 1 year [18]. FibroPlant is a frameless levonorgestrel-releasing IUD with a non-resorbable thread through the center and with similar effects on uterine-bleeding patterns as Mirena [12].
Other IUDs include the copper indomethacin type, available in China, with a silicone elastomer beads containing 25 mg of indomethacin that does not interfere with the copper release and reduces the menstrual cramping [12].
In Austria and Israel, a copper intrauterine ball is available, which once inserted takes the shape of a sphere. The rationale of the ball shape is to reduce the irritating effect of classic copper IUD. It is also easy to insert with no uterine perforation reported and highly accepted by patients [19].
New IUDs, such as flexible VeraCept—that utilize a low-dose copper configuration of 175 mm2 surface area on a shape memory Nitinol frame—need clinical trials for validation of efficacy and tolerability [20] (Figures 1 and 2).
Figure 1.
Various types of IUD. Copper devices presented in the upper row, from left to right: T Safe Cu380A®, Nova T380®, Flexi-T300®, Multiload Cu375®, GyneFix®, Ocon® Cooper intrauterine ball. In the middle row—hormonal IUDs: Mirena®, Skyla®, FibroPlant® frameless levonorgestrel-releasing device. In the lower row, other IUD types are presented, as the indomethacin-releasing cooper device AiMu® and the flexible, low copper dose VeraCept®.
Figure 2.
General structure with stems, arms, and strings of the IUD. Normal location after proper IUD insertion in the middle of the endometrial cavity with no extension in the myometrium, both arms spread toward the uterine horns and the inferior part of the vertical body stem just above the isthmus.
4. IUDs mechanism of action
Both copper and hormonal IUDs involve multiple mechanisms that provide contraceptive protection. The major described effect is represented by the induction of a local inflammatory reaction in the endometrium. Therefore, the endometrial and myometrial function is disturbed by cellular and humoral immune-inflammatory reaction. Intrauterine foreign bodies are known to interfere with reproduction in all species [21]. Other mechanisms of action for copper IUDs are related to copper ions’ effect on the sperm motility and viability and also to changes of the cervical mucus [7]. However, recent studies demonstrated no significant increase in inflammatory reaction, so the effect of copper on the sperm or oocyte remains as the main mechanism of action [22]. The mechanism of inhibiting fertilization or sperm viability impairment may be responsible for the high efficacy of copper IUDs as emergency contraception [23]. The reported failure rate for copper IUD placement for emergency contraception within 5 days of intercourse or ovulation is less than 1‰, significantly more effective than any hormonal emergency contraceptive [24, 25]. Even if copper IUDs do not usually influence the menstrual frequency or quantity, 10–13% of women have their IUD removed in the first year due to increase of menstrual flow and cramping-type abdominal pain [26].
Besides the foreign body reaction, another mechanism of the hormonal IUD is represented by the release of small amount of progestin hormones, respectively, levonorgestrel. The hormonal effects induce an unfriendly and even fatal environment to sperm inside the uterus, with inhibition of capacitation, penetration, and survival [27]. Hormonal IUDs interfere with sperm motility by thickening cervical mucus, thus preventing the sperm to travel up into the uterus [28], while copper IUDs rather impair the sperm viability, with various effects as head-tail disruption [29]. A thinner endometrium develops under the progesterone influence and egg implantation is affected. Also, menstrual blood flow is reduced, thus hormonal IUDs are frequently used to treat menorrhagia [30].
We underline that IUDs, whether hormonal or non-hormonal, do not provide protection against sexually transmitted diseases. Still, the historical association with pelvic inflammatory disease (PID) and tubal infertility is considered false [31, 32].
The indomethacin-releasing copper IUD contains a nonsteroidal anti-inflammatory agent, indomethacin, that do not interfere with copper ions [33, 34], aimed to reduce the menstrual blood flow and cramping that are frequently related by IUDs users [33] (Table 1).
Mechanisms of action
Type of intrauterine device
Copper IUD
Hormonal levonorgestrel IUD
Effects on sperm
Foreign body reaction with toxic changes to sperm
+
+
Copper ions spermicidal or cytotoxic
+
Thickened cervical mucus affecting sperm motility
+
Effects on fertilization
Decreased number of fertilized ova in fallopian tubes
+
+
Effects on the endometrium
Immune-inflammatory reaction with increased leukocytes
+
Altered cytotoxic cytokine and integrin profile
+
+
Endometrial atrophy, decreased thickness, and secretions
+
Table 1.
Mechanisms of action of the main types of IUDs. Modified, Schulman et al. [35].
5. Adverse and side effects, health benefits, and risks of IUDs
Generally, all IUDs are well tolerated with high rates of continuation in all reversible contraception types [36]. All IUD types present potential side effects: uterus perforation and malposition, especially during the inserting technique; embedment and expulsion, as it is a foreign body, and menstrual pattern alterations (Figure 3). All patients should be counseled regarding the possibility of IUD expulsion as this is the most common complication following IUD insertion [37].
The expulsion rate is reported to be similar for copper and hormonal IUDs, as well as in nulliparous versus parous women, approximately 5% [38].
Uterine perforation is rare and surgical intervention is recommended if this occurs, but this is not an emergency in asymptomatic cases [39]. In these patients, a new IUD placement should be considered after at least 4–6 weeks time interval needed for uterine wall healing [40].
A rarely reported complication is the embedment within the endometrium. This should be suspected at the ultrasound (US) follow-up, or clinically, if no IUD strings are visualized at the cervical os or there is difficulty with removal [41].
Copper IUDs can cause menstrual pattern alterations, especially irregular, heavy and painful bleeding, and intermenstrual spotting or bleeding as well throughout use [42, 43].
Regarding the hormonal IUDs side effects, they are similar to other progestin-based contraceptives such as headaches, nausea, hair loss, breast tenderness, depression, decreased libido, and ovarian cysts [44, 45]. Also, vulvovaginitis and abdominal or pelvic pain may be experienced by users of hormonal IUDs [44, 45]. On the contrary to copper IUDs, the hormonal IUDs usually cause amenorrhea and oligomenorrhea after 2 years of use [42, 44].
The contraindications/health risks for IUD use are current pregnancy or gestational trophoblastic disease, cervico-vaginitis or acute pelvic inflammatory disease, including pelvic tuberculosis, puerperal sepsis and recent septic abortion, uterine (cervical or endometrial) cancer, unexplained vaginal bleeding, and malformed uterine cavity. Other systemic contraindications include copper allergy, immunodeficiency disorders, immunosuppressive therapy, Wilson’s disease, acute liver disease or liver carcinoma and breast carcinoma—especially for hormonal IUD, multiple sexual partners for the patient or her partner.
The major health benefit of IUD is represented by the efficacy in contraception similar or better than female sterilization. The cooper IUD failure rate is reported to be 0.8% at 1 year, while a failure rate for hormonal IUD is reported to be 0.1% at 1 year [46, 47]. Of great importance is that this efficacy is not influenced by or related to patient age, multiple medications, or medical comorbidities and does not require patient compliance [48]. IUDs can be safely placed immediately after abortion or 6 weeks postpartum with high contraceptive benefits [49]. Copper IUD is recommended as the most effective option for emergency contraception [50].
Another IUD benefit is the fact that it can be used as an adjunctive treatment modality for intrauterine adhesions. Several studies have shown that IUD can be beneficial in patients with intrauterine adhesions or Asherman’s syndrome, especially when combined with other ancillary treatments [51].
Other noncontraceptive benefits of IUDs include the treatment of menorrhagia, anemia, dysmenorrhea and pelvic pain associated to endometriosis, and endometrial protection during hormone replacement [48]. Since 2009, when Food and Drug Administration (FDA) approved the hormonal IUD as treatment for heavy menstrual bleeding, hormonal IUDs became the most cost-effective alternative to hysterectomy/surgery for the respective patients, with improved hemoglobin concentration [52]. Studies report a decrease of the menstrual blood loss that varies between 74 and 97% at 12 months of use [53, 54]. First, an initial irregular bleeding pattern is noted by most users, but over time the menstrual blood loss is improved. In contrast with copper IUD, the hormonal IUD can also decrease dysmenorrhea [55].
In 30% of patient with deep endometriosis or adenomyosis, an improved control of chronic pelvic pain and dyspareunia is noted after at least 6 months of hormonal IUD use [56, 57].
As the main effect of hormonal IUDs is to decrease the local endometrial response to estrogen, several studies have suggested that this may lead to primary protection from endometrial cancer [58]. Hormonal IUDs can also be used as a component of combined hormone therapy in menopausal women [52].
The use of IUD contraception is considered a health benefit in special groups such as women with comorbidities, in postpartum, postabortion and lactating women, patients with prior thromboembolic events, bleeding diathesis, or under anticoagulation. Also, IUD contraception can be a preferable option in women with uterine fibroids after uterine artery embolization, endometrial ablation, or magnetic resonance-guided focused ultrasound.
However, the IUD does not protect from sexually transmitted diseases; therefore, caution must be considered when selecting IUD users.
6. Correcting misunderstandings, myths, and barriers
6.1. IUD and PID
Since the introduction of IUDs, scientists manifested a concern that this contraception method may cause or facilitate gynecologic infection. In fact, the relationship between IUD and PID has a long and controversial history dating since 1940 [59]. Moreover, in the 1970s, the reputation of IUD was tarnished in many countries, as the use of a Dalkon Shield IUD was linked to several cases of potentially fatal pelvic sepsis [60]. Today, although there is common reserve regarding the PID incidence in the IUD users’ population, valuable research has shown that the risk of PID is no greater with IUD use than the general population [61]. WHO admits a risk of six times greater of PID in the first 20 days after the insertion of IUD [61]. One randomized trial found that the hormonal IUD might provide some protection against PID when compared to the group of copper IUD users and the group of IUD non-users [62]. Due to this risk, prophylactic antibiotics were proposed before IUD insertion, especially doxycycline and/or azithromycin. Multiple large, randomized control studies have demonstrated that the prophylactic antibiotic has no significant beneficial role in reducing the risk of PID before IUD insertion [63].
6.2. IUD and tubal infertility
Tubal infertility was thought to be a consequence of IUD use. Specific research has been conducted and found that the past use of copper IUD did not increase the risk of tubal infertility [59]. Chlamydia infection is the primary cause of PID and tubal infertility in women who use or do not use IUD [31]. A cervix already infected with Chlamydia was considered to be a risk factor for placing an IUD, but proved to have no association with PID on later development [64].
6.3. IUD and the risk of ectopic pregnancy
In the past, IUD was perceived as a high risk factor for ectopic pregnancies (EPs). Actually, a pregnancy with an IUD in situ has an increased risk of being an EP, but the absolute risk of any pregnancy is extremely low in the group of IUD users, much lower than in the group of women with no contraception method [65, 66]. Another important aspect to highlight is that a history of previous EP does not represent a contraindication for IUD insertion [67].
6.4. IUD in nulliparous women
Adolescents and nulliparous women represent a special group that was considered, in the past, not eligible for IUD contraception. Approximately half of adolescents have never heard of IUD contraception [68]. What is more, approximately one-third to one-half of health providers do not offer IUD contraception method to nulliparous women due to several myths and misconceptions [69]. Nowadays, there is sufficient evidence to support the use of IUDs in the nulliparous women as a suitable contraception method, regardless of all false myths and misconceptions including high risk of PID, tubal infertility, EP, gynecological neoplasia, difficulties of the insertion technique, and IUD expulsion [70].
6.5. IUD and gynecological neoplasia
There is a lack of awareness and understanding of IUD contraception by women worldwide, possibly due to lack of medical education and proper information. A frequent misconception of IUD use is that it increases the risk of genital cancer. Mandatory screening for cervical cancer is a requirement of many guidelines before IUD insertion. In fact, several epidemiological studies suggested that IUDs might protect against cervical carcinogenesis [71]. The role of hormonal IUD as a protective factor against endometrial hyperplasia is well known [58]. Accurate information regarding the use of hormonal IUD must underline the risk of ovarian cysts, but not ovarian cancer.
6.6. IUD and female sexual dysfunction
Female sexual dysfunction was thought to be determined by IUD but in fact has a multifactorial etiology and studies found no difference between IUD users or non-users [72].
7. The technique of inserting and removing IUDs
IUD represents the choice method of contraception for many women as its effects are reversible after removal.
The insertion technique is easy and well tolerated by selected female patients after taking into consideration the contraindications, as well as the health benefits for women with anemia, menorrhagia, or dysmenorrhea [73]. First, it is advisable to have a documentation of a negative pregnancy test as a precaution. Also, exclusion of a possible Chlamydia or gonorrhea is advisable before an IUD is inserted [74]. The insertion can be performed at any time during the menstrual cycle [42]. In the past, the technique was preferred to be done during menses to exclude pregnancy, but this is associated with a higher risk of expulsion. Several studies found that the pain during the insertion is lower during the sixth and the tenth days of the menstrual cycle [26]. Regarding the insertion of a hormonal IUD, the appropriate timing is considered to be within the first 5 days of menstrual bleeding or immediately after childbirth, abortion, or switching from an alternative contraceptive method [42, 75]. Backup contraception is recommended for a period of 7 days after the hormonal IUD insertion and is not needed after the copper IUD insertion [48]. In cases of emergency contraception, the insertion of the copper IUD can be done within the 5 days of the unprotected intercourse to prevent pregnancy [25]. The use of a hormonal IUD has not been yet studied and so it is not recommended for emergency contraception. The removal of both the copper IUD and the hormonal IUD can be performed anytime preferably during the menstrual cycle. As mentioned before, antibiotic prophylaxis is not needed before IUD insertion or removal, even in patients at risk for endocarditis [76]. The insertion procedure is usually done by a trained provider in the office, and only in special circumstances, such as mentally limited patients and nulliparous young women, it can be done under sedation. The physician must discuss all risks and benefits of IUD with the patient and must obtain an informed consent. The use of misoprostol before IUD insertion to allow an easier procedure was proposed in 2007 [77]. However, more recent researches found no benefit but increased side effects with misoprostol, and no recommendation has been yet made [78, 79]. On the other hand, the use of a nonsteroidal anti-inflammatory drug, respectively, 600–800 mg of ibuprofen 1 h before the procedure can alleviate discomfort [80]. Also, the physician must educate the patient in locating the IUD threads after each menstruation and consulting earlier if incapacity to locate [80]. IUD insertion is similar for copper IUD and for hormonal IUD. The preparation before IUD insertion must include the determination of uterus position. This can be done by a bimanual examination or by an ultrasound examination. All proper equipment must be sterile and assembled before the procedure. The cervix and vagina must be cleansed with antiseptic solution. A speculum is used to visualize the cervix and a tenculum to stabilize the cervix. Local anesthesia is preferred with lidocaine gel in the cervical canal, or a paracervical block. The uterine depth must be verified using a hysterometer and the IUD is inserted as shown in the accompanying written material of any IUD. After proper insertion, the threads should be cut to a length of 3 cm. A post-procedure ultrasound should be performed to verify the IUD position [81]. The removal procedure should be considered anytime on patient request. If any contraindication appears or adverse effects persist, IUD can be easily removed by grasping the threads at the external os. Special conditions include impossibility to remove the IUD with a simple traction; deeply embedment IUD should be suspected and in such cases, hysteroscopy is mandatory. Cervical screening is performed the same as in IUD non-users. Colposcopy is performed the same, but excisional procedure for cervical dysplasia must be performed after IUD removal [81].
8. The role of ultrasound in IUD users
US evaluation of the pelvis, especially transvaginally, has become an important part of the gynecological care and is essential for the assessment of IUD position after insertion [81]. Moreover, the lack of a pelvic US examination before IUD insertion may predispose to malposition or serious complications such as perforation [82]. US assessment is cheap, easy to learn, perform and interpret, efficient, and without side effects [81]. A correct positioned IUD is visualized in the middle of the endometrial cavity with no extension in the myometrium, with both arms spread toward the uterine horns and the inferior part of the vertical body of the IUD just above the isthmic portion of the uterus [83] (Figure 4). The two-dimensional technique has some limits in the evaluation of the IUD position, as the most important plane for this purpose, the coronal plane, usually cannot be imagined. Three-dimensional (3D) assessment is also helpful to identify hormonal IUD, because of the lack of echogenicity (Figure 4B), unlike copper IUD that are easily identified due to its high echogenity.
Figure 4.
Ultrasound image of hormonal IUD. (A) 2D image; (B) 3D rendering, with reconstruction of the coronal plane.
About 10% of IUDs are malpositioned and so the efficacy in contraception is significantly decreased. More than half of the patients with a malpositioned IUD are asymptomatic. Still, there are no general guidelines for a routine transvaginally US verification after IUD insertion [84]. The 3D US technique has the advantage to allow subsequent reconstruction of the coronal plane [83]. This approach provides a correct diagnosis regarding the malposition, expulsion, displacement, embedment, or perforation (Figure 5). It can also detect more specifically uncommon complications such as fragmentation and calcification [81]. So, 3D has become crucial as it is more sensitive in assessing symptomatic IUD users, but also for routine evaluation. However, familiarity with the transvaginal 2D/3D US techniques is essential.
Figure 5.
Ultrasound image of a malpositioned copper IUD. (A) 2D image; (B) 3D rendering of the coronal plane showing copper IUD displacement; (C) 3D rendering showing copper IUD partial embedment into myometrium.
9. Management of problems in continuing users
Patient satisfaction and acceptability are extremely important regardless of their contraceptive method. After a proper counseling regarding the risks and the benefits, women choose the appropriate most effective contraception option to prevent an undesired pregnancy. The continuation rates for copper IUD are reported to be as high as 84% at 12 months and 85% for hormonal IUD [85]. Overall, the satisfaction rates of women users of IUDs are the highest between all other contraceptive methods [86]. In terms of IUDs advantages, the most frequently reported reasons are the ease of use, efficacy, and reliability, but also reduction of the menstrual flows when using a hormonal IUD [40].
Pelvic pain is the most frequent side effect of any IUDs. Approximately 27% of copper IUD users and 34% of hormonal IUD users have their IUD removed prior to 6 months because of continuing cramping [87]. The post-insertion pain can be managed with 400 mg of ibuprofen/325–650 mg of aspirin/325–1000 mg of paracetamol/200 mg of naproxen. The post-insertion recommendations forbid tampons, vaginal douching, and sex for 24 h [48].
Another reason for discontinuation is represented by irregular bleeding patterns especially for hormonal IUD users. With the copper IUDs, most women continue to have regular monthly periods and bleeding may get heavier [48]. In such cases, tranexamic acid can be required for a short-term relief, but unfortunately, it is not available in many countries. Another option may be nonsteroidal anti-inflammatory drugs, such as indomethacin, but not aspirin. Anemia may be a serious side effect of using copper IUD, so patients must receive iron tablets for the anemia prevention or indication to a specific diet rich in foods containing iron. Amenorrhea is a common side effect when using hormonal IUD. Even if irregular bleeding may bother the user, the menstrual flow is overall decreased [88]. In adolescents, a 7% rate of discontinuation has been reported within the first year, independent to the IUD type, due to abnormal bleeding [89].
Most cases of discontinuation can be prevented by an accurate medical informed discussion between the user and the health provider prior to IUD insertion. Both types of IUD should be taken into consideration and the best decision must consider the benefits, but also all adverse effects. The most important disadvantage of IUD use is the fact that it does not offer protection from sexually transmitted diseases and condom should be used for this purpose. In rare cases, the male partner can feel the IUD retrieval strings or stem during intercourse and this may bother him. Strings can be cut shorter or in some cases the IUD can be removed and a new one inserted. Lack of medical education seems to be the main cause for the reduced uptake and continuation rates for intrauterine contraception among female patients [90].
10. When to switch to other contraception methods
Other contraception methods should be considered if menstrual bleeding is increased when using copper IUDs or if irregular bleeding induced by using the hormonal IUDs becomes a disturbance in the female patient’s routine.
PID or EP represents a cause for severe pain in the lower abdomen. However, PID does not represent an indication to remove the IUD before starting antibiotic treatment. If EP is diagnosed, IUD must be removed and proper specific treatment should be initiated. IUD should be removed also in intrauterine pregnancy cases. If the woman wants to terminate the pregnancy, the removal procedure is done before the evacuation of the uterus. If the woman wants to continue the pregnancy, early removal of the IUD reduces the risk of preterm delivery or miscarriage.
During the insertion procedure, perforation may be suspected. In such situations, immediate removal of the IUD is recommended along continuous monitoring of the patient’s vital signs. If perforation is suspected after 6 weeks of insertion or later, then the IUD should be removed by an experienced clinician and other contraception method should be considered.
If the IUD is partially expelled, it must be removed and insertion of a new one should be decided with the patient after careful counseling. If the IUD is completely expelled, then other contraceptive methods are advisable.
Male discomfort during intercourse is a rare cause for switching to other contraception methods.
11. New alternative to IUD
A series of medical conditions, due to high maternal mortality rates approaching 50%, represent an imperative indication for the most reliable methods of contraception in women. Essure was introduced in 2002 as a new sterilization method for women who do not desire to preserve fertility or for those who have significant medical contraindications. Essure is composed of two intra-tubal stents that must be inserted into the proximal section of the fallopian tube. This procedure is done hysteroscopically using only oral analgesia or sedation [91]. The contraceptive effect is installed in 3 months after insertion due to mechanical obstruction and inflammation causing fibrosis [92]. Thus, an additional form of contraception must be used in the meantime other than IUD. The main advantages of Essure are represented by the fact that Essure is non-incisional, permanent birth control device [93]. The insertion procedure is ideally performed in the proliferative phase when the tubal ostia can be easily visualized and cannulated. Tubal stenosis and tubal spasm can determine the failure of placement, but also poor visualization [94]. The procedure success rate varies from 85 to 98% [95]. When inserted, there is a risk of vaso-vagal attacks of 1.85% [96]. The Essure contraindications are the uncertainty regarding ending fertility, suspected pregnancy, active or recent PID, uterine anomalies, less than a 6-week interval after delivery or miscarriage, patient unwilling to use other contraceptive methods for the first 3 months, prior tubal ligation, and current immunosuppressive therapy [97]. After 3 months post-insertion, an imaging method to verify the position of the Essure is recommended. Several studies have been done in order to establish the best imaging method between hysterosalpingogram (HSG), X-ray, or hysterosalpingo-contrast sonography. Still, all studies underline the importance of trained staff in assessing the appropriate Essure placement [93] (Figure 6). As complications, mild pain has been reported in most cases—80% of patients, while severe pain may be encountered in 17% [98]. Also, minor symptoms like cramping, nausea, and light bleeding or spotting can also occur in the first week [3]. Severe complications like tubal perforation and expulsion are rare. Essure is compatible with 1.5 T of magnetic resonance imaging (MRI), but special caution is indicated in 3 T MRI and with some techniques of endometrial ablation. In terms of efficacity, Essure has a 99.74% successful rate in permanent contraception after 5 years [97]. The minimal risk of pregnancy with Essure can be overcome by educating patients to respect the recommended instructions and comply to periodic follow-ups, including HSG protocol [98].
Figure 6.
The Essure system and placement of the device.
\n',keywords:"intrauterine device, copper intrauterine device, hormonal intrauterine device, contraception, family planning, ultrasound",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/58267.pdf",chapterXML:"https://mts.intechopen.com/source/xml/58267.xml",downloadPdfUrl:"/chapter/pdf-download/58267",previewPdfUrl:"/chapter/pdf-preview/58267",totalDownloads:2145,totalViews:1112,totalCrossrefCites:1,totalDimensionsCites:1,totalAltmetricsMentions:4,impactScore:1,impactScorePercentile:63,impactScoreQuartile:3,hasAltmetrics:1,dateSubmitted:"July 10th 2017",dateReviewed:"November 6th 2017",datePrePublished:"December 20th 2017",datePublished:"June 13th 2018",dateFinished:"December 16th 2017",readingETA:"0",abstract:"Intrauterine devices (IUDs) represent one of the most important methods used for contraception. The methods vary in terms of efficiency, acceptability, costs, and potential complications. Early methods have been improved, and ultrasound (US) evaluation has become an important tool to diagnose the clear majority of IUDs complications. This chapter presents a comprehensive and up-to-date status regarding the use of intrauterine devices (IUDs) for birth control and family planning. The topics discussed in the manuscript will involve the current knowledge on the history, types, mechanisms, health benefits, and risks. More, the present paper presents the medical techniques for inserting and removing a IUD, and the role of US to confirm proper IUD placement. Also, this chapter offers practical guidance in managing problems of continuing users and discusses the clinical circumstances that require reconsideration of the contraception methods.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/58267",risUrl:"/chapter/ris/58267",book:{id:"6142",slug:"family-planning"},signatures:"Iliescu Dominic Gabriel, Ștefania Tudorache, Simona Vlădăreanu,\nNuți Daniela Oprescu, Maria Cezara Mureșan, Roxana Cristina\nDrăgușin and Iuliana Ceaușu",authors:[{id:"209081",title:"Dr.",name:"Stefania",middleName:null,surname:"Tudorache",fullName:"Stefania Tudorache",slug:"stefania-tudorache",email:"stefania.tudorache@gmail.com",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/209081/images/5462_n.jpg",institution:null},{id:"212459",title:"Dr.",name:"Dominic",middleName:null,surname:"Iliescu",fullName:"Dominic Iliescu",slug:"dominic-iliescu",email:"dominic.iliescu@yahoo.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Medicine and Pharmacy of Craiova",institutionURL:null,country:{name:"Romania"}}},{id:"212490",title:"Dr.",name:"Dragusin",middleName:null,surname:"Roxana",fullName:"Dragusin Roxana",slug:"dragusin-roxana",email:"roxy_dimieru@yahoo.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Craiova",institutionURL:null,country:{name:"Romania"}}},{id:"215126",title:"Prof.",name:"Simona",middleName:null,surname:"Vladareanu",fullName:"Simona Vladareanu",slug:"simona-vladareanu",email:"simconst69@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"215135",title:"Prof.",name:"Iuliana",middleName:null,surname:"Ceausu",fullName:"Iuliana Ceausu",slug:"iuliana-ceausu",email:"iulianaceausu2004@yahoo.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"216852",title:"Prof.",name:"Dana",middleName:null,surname:"Oprescu",fullName:"Dana Oprescu",slug:"dana-oprescu",email:"dana.oprescu@hotmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"230814",title:"Assistant Prof.",name:"Maria Cezara",middleName:null,surname:"Muresan",fullName:"Maria Cezara Muresan",slug:"maria-cezara-muresan",email:"drmuresan@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Victor Babeș University of Medicine and Pharmacy Timișoara",institutionURL:null,country:{name:"Romania"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. History of IUDs",level:"1"},{id:"sec_3",title:"3. Types of IUDs: copper and hormonal",level:"1"},{id:"sec_4",title:"4. IUDs mechanism of action",level:"1"},{id:"sec_5",title:"5. Adverse and side effects, health benefits, and risks of IUDs",level:"1"},{id:"sec_6",title:"6. Correcting misunderstandings, myths, and barriers",level:"1"},{id:"sec_6_2",title:"6.1. IUD and PID",level:"2"},{id:"sec_7_2",title:"6.2. IUD and tubal infertility",level:"2"},{id:"sec_8_2",title:"6.3. IUD and the risk of ectopic pregnancy",level:"2"},{id:"sec_9_2",title:"6.4. IUD in nulliparous women",level:"2"},{id:"sec_10_2",title:"6.5. IUD and gynecological neoplasia",level:"2"},{id:"sec_11_2",title:"6.6. IUD and female sexual dysfunction",level:"2"},{id:"sec_13",title:"7. The technique of inserting and removing IUDs",level:"1"},{id:"sec_14",title:"8. The role of ultrasound in IUD users",level:"1"},{id:"sec_15",title:"9. Management of problems in continuing users",level:"1"},{id:"sec_16",title:"10. When to switch to other contraception methods",level:"1"},{id:"sec_17",title:"11. New alternative to IUD",level:"1"}],chapterReferences:[{id:"B1",body:'Winner B, Peipert JF, Zhao Q, Buckel C, Madden T, Allsworth JE, Secura GM. Effectiveness of long-acting reversible contraception. New England Journal of Medicine. 2012;366(21):1998-2007. PMID 22621627. DOI: 10.1056/NEJMoa1110855'},{id:"B2",body:'Committee on Adolescent Health Care Long-Acting Reversible Contraception Working Group, The American College of Obstetricians and, Gynecologists. Committee opinion no. 539: adolescents and long-acting reversible contraception: implants and intrauterine devices. Obstetrics and gynecology. October 2012;120(4):983-988. PMID: 22996129. DOI: 10.1097/AOG.0b013e3182723b7d'},{id:"B3",body:'Guttmacher AF. Intra-uterine contraceptive devices. Journal of Reproduction and Fertility. 1965;10:115-128'},{id:"B4",body:'Richter R. Ein Mittel zur Verhueturng der Konzeption. Deutsche Medizinische Wochenschrift. 1909;35:1525-1527'},{id:"B5",body:'Margulies L. History of intrauterine devices, Bulletin of the New York Academy of Medicine. 1975 May;51(5):662-7'},{id:"B6",body:'Sivin I, Greenslade F, Schmidt F, Waldman SN. The Copper 380 Intrauterine Device: A Summary of Scientific Data. New York: Population Council, Inc; 1992. 1-50'},{id:"B7",body:'Hsia JK, Creinin MD. Intrauterine contraception. Seminars in Reproductive Medicine. 2016;34(3):175-182. DOI: 10.1055/s-0036-1571438'},{id:"B8",body:'Hubacher D. The checkered history and bright future of intrauterine contraception in the United States. Perspectives on Sexual and Reproductive Health. 2002 Mar-Apr;34(2):98-103'},{id:"B9",body:'Spinelli A, Talamanca IF, Lauria L. Patterns of contraceptive use in 5 European countries. American Journal of Public Health. 2000;90(9):1403-1408'},{id:"B10",body:'World Contraceptive Use 2012 (United Nations publication, POP/DB/CP/Rev2012); 2013 Update for the MDG Database: Contraceptive Prevalence (United Nations publication, POP/DB/CP/A/MDG2013); and 2013 Update for the MDG Database: UnmetNeed for Family Planning (United Nations publication, POP/DB/CP/B/MDG2013). Available http://www.un.org/en/development/desa/population/publications/pdf/family/worldContraceptivePatternsWallChart2013'},{id:"B11",body:'Sutherland EG, Otterness C, Janowitz B. What happens to contraceptive use after injectables are introduced? An analysis of 13 countries.International Perspectives on Sexual and Reproductive Health. 2011;37:202-208'},{id:"B12",body:'Jo Dennis, MFFP, MRCGP, Career Grade Trainee, IUDs: Which device? The Journal of Family Planning and Reproductive Health Care 2002;28(2)'},{id:"B13",body:'Sivin I. Utility and drawbacks of continuous use of a copper T IUD for 20 years. Contraception. 2007;75(6, Suppl):S70-S75'},{id:"B14",body:'Cao X, Zhang W, Gao Y, et al. Immediate post-abortal insertion of the frameless GyneFix IUD: initial experience in China. British Journal of Family Planning. 2000;26:85-88'},{id:"B15",body:'http://www.eurogine.com'},{id:"B16",body:'Bayer Healthcare Pharmaceuticals Inc. Mirena Full Prescribing Information. 2014; Available at: http://labeling.bayerhealthcare.com/html/products/pi/Mirena_PI.pdf'},{id:"B17",body:'Bayer Healthcare Pharmaceuticals Inc. Skyla Full Prescribing Information. 2013. Available at: http://labeling.bayerhealthcare.com/html/products/pi/Skyla_PI.pdf'},{id:"B18",body:'Eisenberg DL, Schreiber CA, Turok DK, Teal SB, Westhoff CL, Creinin MD, ACCESS IUS Investigators. Three-year efficacy and safety of a new 52-mg levonorgestrel-releasing intrauterine system. Contraception 2015;92(1):10-16'},{id:"B19",body:'Baram I, Weinstein A, Trussell J. The IUB, a newly invented IUD: a brief report. Contraception. 2014;89(2):139-141'},{id:"B20",body:'Reeves MF, Hathaway MJ, Canela Oleaga JM, Katz BH, Tal MG. A randomized single-blinded trial of VeraCept, a novel nitinol lowdose copper intrauterine contraceptive compared with a copper T380S intrauterine contraceptive [Abstract]. Obstetrics and Gynecology. 2015;125(5, Suppl):5s'},{id:"B21",body:'Ortiz ME, Croxatto HB, Bardin CW. Mechanisms of action of intrauterine devices. Obstetrical and Gynecological Survey. 1996;51(12 SUPPL)'},{id:"B22",body:'Achilles SL, Creinin MD, Stoner KA, Chen BA, Meyn L, Hillier SL. Changes in genital tract immune cell populations after initiation of intrauterine contraception. American Journal of Obstetrics and Gynecology. 2014;211(5):489'},{id:"B23",body:'Sonalkar S, Schreiber CA, Barnhart KT. Contraception. [Updated 2014 Nov 11]. In: De Groot LJ, Chrousos G, Dungan K, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279148/'},{id:"B24",body:'ACOG. Practice bulletin 152: Emergency contraception. Obstetrics and Gynecology 2015;126(3):685-686'},{id:"B25",body:'Cleland K, Zhu H, Goldstuck N, Cheng L, Trussell J. The efficacy of intrauterine devices for emergency contraception: A systematic review of 35 years of experience. Human Reproduction. 2012;27(7):1994-2000'},{id:"B26",body:'Hubacher D, Reyes V, Lillo S, et al. Preventing copper intrauterine device removals due to side effects among first-time users: Randomized trial to study the effect of prophylactic ibuprofen. Human Reproduction. 2006;21(6):1467-1472'},{id:"B27",body:'Speroff L, Darney PD. Intrauterine Contraception. A Clinical Guide for Contraception. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2011. pp. 239-280. ISBN: 978-1-60831-610-6'},{id:"B28",body:'Lewis RA, Taylor D, Natavio MF, Melamed A, Felix J, Mishell D Jr. Effects of the levonorgestrel-releasing intrauterine system on cervical mucus quality and sperm penetrability. Contraception 2010;82(6):491-496'},{id:"B29",body:'Croxatto HB, Ortiz ME, Valdez E. IUD mechanism of action. In: Bardin CW, Mishell DR Jr, eds. Proceedings from the Fourth International Conference on IUDs. London:Butterworth-Heinemann, 1994:44-62'},{id:"B30",body:'Bahamondes L, Valeria Bahamondes M, Monteiro I. Levonorgestrel-releasing intrauterine system: Uses and controversies. Expert Review of Medical Devices. 2008;5:437-445. PMID: 18573044. DOI: 10.1586/17434440.5.4.437'},{id:"B31",body:'Hubacher D, Lara Ricalde R, Taylor DJ, Guerra Infante F, Guzman Rodriguez R. Use of intrauterine device and the risk of infertility among nulligravid women. New England Journal of Medicine. 2001;345:561-567'},{id:"B32",body:'Shelton JD. Risk of clinical pelvic inflammatory disease attributable to an intrauterine device. Lancet. 2001;257:443'},{id:"B33",body:'Zhao G, Li M, Zhu P, Xu R, Wang J, Xu R. A preliminary morphometric study on the endometrium from patients treated with indomethacin-releasing copper intrauterine device. Human Reproduction. 1997;12(7):1563-1566'},{id:"B34",body:'Tian K, Xie C, Xia X. Chitosan/alginate multilayer film for controlled release of IDM on Cu/LDPE composite intrauterine devices. Colloids Surface B Biointerfaces. 2013;109:82-89'},{id:"B35",body:'Schulman L, Hess HM, Arias R, et al. Expert Roundtable. Intrauterine contraception: Patient and clinician considerations. OBG Management. 2009;July(Supplement):S1 8'},{id:"B36",body:'Trussell J. Contraceptive failure in the United States. Contraception. 2011;83(5):397-404'},{id:"B37",body:'Russo JA, Miller E, Gold MA. Myths and misconceptions about long-acting reversible contraception (LARC). Journal of Adolescent Health. 2013;52(4 Suppl):S14-S21'},{id:"B38",body:'Brockmeyer A, Kishen M, Webb A. Experience of IUD/IUS insertions and clinical performance in nulliparous women – a pilot study. The European Journal of Contraception & Reproductive Health Care. 2008;13(3):248-254'},{id:"B39",body:'Mechanism of action, safety and efficacy of intrauterine devices. Report of a WHO Scientific Group. World Health Organ Tech Rep Ser. 1987;753:1-91'},{id:"B40",body:'Bednarek PH, Jensen JT. Safety, efficacy and patient acceptability of the contraceptive and non-contraceptive uses of the LNG-IUS. International Journal of Womens Health. 2010;1:45-58'},{id:"B41",body:'Kaislasuo J, Suhonen S, Gissler M, Lähteenmäki P, Heikinheimo O. Uterine perforation caused by intrauterine devices: Clinical course and treatment. Human Reproduction. 2013;28(6):1546-1551'},{id:"B42",body:'American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 121: Long-acting reversible contraception: Implants and intrauterine devices. Obstetrics and Gynecology. 2011;118(1):184-196'},{id:"B43",body:'Paragard T 380 A. Intrauterine copper contraceptive [package insert]. Sellersville, Pa.; 2013. http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/018680s066lbl.pdf. Accessed June 10, 2013'},{id:"B44",body:'U.S. Food and Drug Administration. Mirena (levonorgestrelreleasing intrauterine system) July 2008. Safety labeling changes approved by FDA Center for Drug Evaluation and Research (CDER). http://www.fda.gov/safety/medwatch/safetyinformation/safetyrelateddruglabelingchanges/ucm121936.htm. Accessed June 9, 2012'},{id:"B45",body:'Skyla (levonorgestrel-releasing intrauterine system) [package insert]. Wayne NJ: Bayer HealthCare Pharmaceuticals, Inc.; 2013. http://labeling.bayerhealthcare.com/html/products/pi/Skyla_PI.pdf. Accessed June 10, 2013'},{id:"B46",body:'Hatcher RA, Trussell J, Nelson AL, Cates W Jr, Stewart FH, Kowal D. Contraceptive Technology. 19th rev ed. Ardent Media: New York (NY); 2007'},{id:"B47",body:'Trussell J. Contraceptive failure in the United States. Contraception. 2011;83(5):397-404'},{id:"B48",body:'Yoost J, Understanding benefits and addressing misperceptions and barriers to intrauterine device access among populations in the United States, Patient Prefer Adherence. 2014 Jul 3;8:947-57. DOI: 10.2147/PPA.S45710. eCollection 2014'},{id:"B49",body:'Centers for Disease Control and Prevention (CDC). US Medical Eligibility Criteria for Contraceptive Use, 2010. MMWR Recomm Rep. 2010;59(RR-4):1-86'},{id:"B50",body:'Cleland K, Raymond EG, Westley E, Trussell J. Emergency contraception review: Evidence-based recommendations for clinicians, Clinical Obstetrics and Gynecology. 2014 Dec;57(4):741-750'},{id:"B51",body:'Salma U, Xue M, Md Sayed AS, Xu D. Efficacy of intrauterine device in the treatment of intrauterine adhesions. Biomed Research International. 2014;2014:589296. DOI: 10.1155/2014/589296'},{id:"B52",body:'Hubacher D, Grimes DA. Noncontraceptive health benefits of intrauterine devices: A systematic review. Obstetrics and Gynecology Survey. 2002;57(2):120-128'},{id:"B53",body:'Cameron IT. Randomised comparative trial of the levonorgestrel intrauterine system and norethisterone for treatment of idiopathic menorrhagia. British Journal of Obstetrics and Gynaecology. 1998;105(6):592-598'},{id:"B54",body:'Barrington JW, Bowen-Simpkins P. The levonorgestrel intrauterine system in the management of menorrhagia. British Journal of Obstetrics and Gynaecology. 1997;104(5):614-616'},{id:"B55",body:'Lindh I, Milsom I. The influence of intrauterine contraception on the prevalence and severity of dysmenorrhea: A longitudinal population study. Human Reproduction. 2013;28(7):1953-1960'},{id:"B56",body:'Vercellini P, Aimi G, Panazza S, De Giorgi O, Pesole A, Crosignani PG. A levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhea associated with endometriosis: A pilot study. Fertility and Sterility. 1999;72(3):505-508'},{id:"B57",body:'Vercellini P, Frontino G, De Giorgi O, Aimi G, Zaina B, Crosignani PG. Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study. Fertility and Sterility. 2003;80(2):305-309'},{id:"B58",body:'Mueck AO, Seeger H, Rabe, Hormonal contraception and risk of endometrial cancer: A systematic review, Endocrine Related Cancer. 2010 Sep 23;17(4):R263-R271. DOI: 10.1677/ERC-10-0076'},{id:"B59",body:'Hubacher D. Intrauterine devices & infection: Review of the literature. Indian Journal of Medical Research. 2014 Nov;140(Suppl):S53-S57'},{id:"B60",body:'MacIsaac L, Espey E. Intrauterine contraception: The pendulum swings back. Obstetrics and Gynecology Clinics of North America. 2007;34:91-111'},{id:"B61",body:'Farley TM, Rosenberg MJ, Rowe PJ, Chen JH, Meirik O. Intrauterine devices and pelvic inflammatory disease: An international perspective. Lancet. 1992;339(8796):785-788'},{id:"B62",body:'Toivonen J, Luukkainen T, Allonen H. Protective effect of intrauterine release of levonorgestrel on pelvic infection: Three years ’ comparative experience of levonorgestrel- and copper-releasing intrauterine devices. Obstetrics and Gynecology. 1991;77:261-264'},{id:"B63",body:'Walsh T, Grimes D, Frezieres R, et al. Randomised controlled trial of prophylactic antibiotics before insertion of intrauterine devices. IUD Study Group. Lancet. 1998;351:1005-1008'},{id:"B64",body:'Pap-Akeson M, Solheim F, Thorbert G, et al. Genital tract infections associated with the intrauterine contraceptive device can be reduced by inserting the threads into the uterine cavity. British Journal of Obstetrics and Gynaecology. 1992;99:676-679'},{id:"B65",body:'Sivin I. Dose- and age-dependent ectopic pregnancy risks with intrauterine contraception. Obstetrics and Gynecology. 1991;78(2):291-298'},{id:"B66",body:'Skjeldestad FE. How effectively do copper intrauterine devices prevent ectopic pregnancy? Acta Obstetricia et Gynecologica Scandinavica. 1997;76:684-690'},{id:"B67",body:'World Health Organization. Medical Eligibility Criteria for Contraceptive Use. 4th edn. Geneva: WHO. 2010. Accessed 12 April 2012 from: http://www.who.int/reproductive.health/publications/mec.pdf'},{id:"B68",body:'Stanwood NL, Bradley KA. Young pregnant women’s knowledge of modern intrauterine devices. Obstetrics and Gynecology. 2006;108(6):1417-1422'},{id:"B69",body:'Kavanaugh ML, Frohwirth L, Jerman J, Popkin R, Ethier K. Long-acting reversible contraception for adolescents and young adults: Patient and provider perspectives. Journal of Pediatric & Adolescent Gynecology. 2013;26(2):86-95'},{id:"B70",body:'Black K, Lotke P, Buhling KJ, Zite NB. Intrauterine contraception for Nulliparous women: Translating Research into Action (INTRA) group, A review of barriers and myths preventing the more widespread use of intrauterine contraception in nulliparous women. European Journal of Contraception & Reproductive Health Care. 2012 Oct;17(5):340-350. DOI: 10.3109/13625187.2012.700744 Epub 2012 Jul 26'},{id:"B71",body:'Castellsague X, Diaz M, Vaccarella S, et al. Intrauterine device use, cervical infection with human papillomavirus, and risk of cervical cancer: A pooled analysis of 26 epidemiological studies. Lancet Oncology. 2011;12:1023-1031'},{id:"B72",body:'Koseoglu SB, Deveer R, Akin MN, Gurbuz AS, Kasap B, Guvey H. Is there any impact of copper intrauterine device on female sexual functioning? Journal of Clinical and Diagnostic Research. 2016 Oct;10(10):QC21-QC23'},{id:"B73",body:'IUDs—an update. Popul Rep B. 1995;6:1-35'},{id:"B74",body:'American College of Obstetricians and Gynecologists. The Intrauterine Device. ACOG technical bulletin no. 164. Washington, D.C: ACOG, 1992'},{id:"B75",body:'Bednarek PH, Jensen JT. Safety, efficacy and patient acceptability of the contraceptive and non-contraceptive uses of the LNG-IUS. International Journal of Womens Health. 2010;1:45-58'},{id:"B76",body:'Dajani AS, Taubert KA, Wilson W, Bolger AF, Bayer A, Ferrieri P, et al. Prevention of bacterial endocarditis. Recommendations by the American Heart Association. Circulation 1997;96:358-66'},{id:"B77",body:'Sääv I, Aronsson A, Marions L, Stephansson O, Gemzell-Danielsson K. Cervical priming with sublingual misoprostol prior to insertion of an intrauterine device in nulliparous women: a randomized controlled trial. Human Reproduction. 2007;22(10):2647-2652'},{id:"B78",body:'Dijkhuizen K, Dekkers OM, Holleboom CA, et al. Vaginal misoprostol prior to insertion of an intrauterine device: an RCT. Human Reproduction. 2011;26(2):323-329'},{id:"B79",body:'Edelman AB, Schaefer E, Olson A, et al. Effects of prophylactic misoprostol administration prior to intrauterine device insertion in nulliparous women. Contraception. 2011;84(3):234-239'},{id:"B80",body:'Johnson BA. Insertion and removal of intrauterine devices. American Family Physician. 2005 Jan 1;71(1):95-102'},{id:"B81",body:'Nowitzki KM, Hoimes ML, Chen B, Zheng LZ, Kim YH. Ultrasonography of intrauterine devices. Ultrasonography. 2015 Jul;34(3):183-194'},{id:"B82",body:'Valsky DV, Cohen SM. The shadow of the intrauterine device. Journal of Ultrasound Medicine. 2006 May;25(5):613-616'},{id:"B83",body:'Drăguşin R-C, Florea M, Pătru CL, Iliescu DG, Cernea N, Tudorache S, Benefits of 3D ultrasound in the diagnosis of intrauterine device malposition. Obstetrica si Ginecologia. 2016;64'},{id:"B84",body:'Nadai MN, Martins WP, Ferriani RA, Vieira CS. Three-dimensional ultrasound imaging of an intrauterine device showing copper corrosion. Ultrasound in Obstetrics and Gynecology. 2013 Nov;42(5):606-607'},{id:"B85",body:'Peipert JF, Zhao Q, Allsworth JE, et al. Continuation and satisfaction of reversible contraception. Obstetrics and Gynecology. 2011;117(5):1105-1113'},{id:"B86",body:'Forrest JD. US women’s perceptions of and attitudes about the IUD. Obstetrics and Gynecology Survey. 1996;51(12 Suppl):S30-S34'},{id:"B87",body:'Grunloh DS, Casner T, Secura GM, Peipert JF, Madden T. Characteristics associated with discontinuation of long-acting reversible contraception within the first 6 months of use. Obstetrics and Gynecology. 2013;122(6):1214-1221'},{id:"B88",body:'Nelson A, Apter D, Hauck B, et al. Two low-dose levonorgestrel intrauterine contraceptive systems: A randomized controlled trial. Obstetrics and Gynecology. 2013;122(6):1205-1213'},{id:"B89",body:'Teal SB, Sheeder J. IUD use in adolescent mothers: Retention, failure and reasons for discontinuation. Contraception. 2012;85:270-274'},{id:"B90",body:'Peipert J, Zhao Q, Allsworth J, et al. Continuation and satisfaction of reversible contraception. Obstetrics and Gynecology. 2011;117:1105-1113'},{id:"B91",body:'Duffy S, Marsh F, Rogerson L, et al. Female sterilisation: A cohort controlled comparative study of ESSURE versus laparoscopic sterilisation. BJOG. 2005;112:1522-1528'},{id:"B92",body:'Dhanjal MK. Contraception in women with medical problems. Obstetric Medicine. 2008 Dec;1(2):78-87. DOI: 10.1258/om.2008.080014'},{id:"B93",body:'Sagili H, Divers M. Hysteroscopic sterilisation with Essure: A promising new alternative to tubal ligation? Journal of Family Planning and Reproductive Health Care. 2008 Apr;34(2):99-102'},{id:"B94",body:'Sinha D, Kalathy V, Gupta JK, Clark TJ. The feasibility, success and patient satisfaction associated with outpatient hysteroscopic sterilisation. British Journal of Obstetrics and Gynaecology. 2007;114:676-683'},{id:"B95",body:'Kerin JF, Munday DN, Ritossa MG, Pesce A, Rosen D. Essure hysteroscopic sterilization: results based on utilizing a new coil catheter delivery system. Journal of American Association of Gynecologic Laparoscopists. 2004;11:388-393'},{id:"B96",body:'Agostini A, Bretelle F, Ronda I, Roger V, Cravello L, Blanc B. Risk of vasovagal syndrome during outpatient hysteroscopy. Journal of American Association of Gynecologic Laparoscopists. 2004;11:245-247'},{id:"B97",body:'Conceptus website. http://www.conceptus.com/ [Accessed 4 August 2007]'},{id:"B98",body:'Cooper JM, Carignan CS, Cher D, Kerin JF. Selective Tubal Occlusion Procedure 2000 Investigators Group. Microinsert nonincisional hysteroscopic sterilization. Obstetrics and Gynecology. 2003;102:59-67'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Iliescu Dominic Gabriel",address:null,affiliation:'
Department of Obstetrics and Gynaecology, University of Medicine and Pharmacy, Romania
Department of Obstetrics and Gynaecology, University of Medicine and Pharmacy of Bucharest, Romania
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1. Introduction
The Republic of Suriname is a small independent country in South America that is renowned for its ethnic, cultural, and religious diversity [1]. The Javanese are currently the fourth most numerous ethnic group in Suriname, after the Hindustanis, the Creoles, and the Maroons [1]. The Javanese are the descendants of indentured laborers from particularly the Indonesian island of Java who were attracted by the Dutch colonizers from the former Dutch East Indies - modern-day Indonesia - at the end of the 19th century to work on the sugar cane plantations in Suriname following the abolition of slavery in the year 1863 [2, 3]. They had signed contracts for five years, and although some returned to their home country and others relocated to The Netherlands [2, 3], most remained in Suriname and settled in the district of Commewijne where the first groups of Javanese had been put to work [2, 3].
Today, only five generations later, the Javanese have integrated well in Suriname, actively participating in all sections of the society including politics, arts, entertainment, and sports. For instance, Iding and Willy Soemita and Paul Somohardjo were prominent Surinamese Javanese politicians. Iding Soemita was born in West Java and came as an indentured laborer to Suriname, and founded the political party Kerukunan Tulodo Pranatan Inggil (KTPI) in 1949, giving Surinamese Javanese for the first time a political voice. Iding Soemita’s son Willy succeeded his father as chairman of the KTPI in 1972 and served several times as a minister until 1996. As a more outspoken and assertive alternative to the KTPI, Paul Somohardjo founded the Javanese party Pendawa Lima in 1977 that was superseded in 1998 by the Pertjajah Luhur. Somohardjo became the first-ever Javanese Speaker of the National Assembly in 2005 and also served several terms as a minister.
The Surinamese-Javanese writer Karin Amatmoekrim studied Modern Literature at the University of Amsterdam, graduated with a thesis on ‘The ethnicity in literature in Suriname’, and won the 2009-Black Magic Woman Literature Prize for her novel ‘Titus’. The Surinamese-Javanese singers Ragmad Amatstam, Oesje Soekatma, and Eddy Assan are among the greatest and most beloved musicians Suriname has brought forth. Specializing in pop-Jawa songs, they reached a broad audience in both Suriname and The Netherlands. Notable Surinamese-Javanese sports heroes are Andy Atmodimedjo, Virgil Soeroredjo, and Mitchel Wongsodikromo. Andy Atmodimedjo was an impressive professional football player and became the successful manager of several clubs in Suriname’s highest soccer league as well as the head coach of the country’s senior and under-21 national soccer teams. And Virgil Soeroredjo and Mitchel Wongsodikromo were among the world’s top badminton players who excelled on various national, Caribbean, Central American, and South American competitions.
Nevertheless, the Javanese have preserved their own identity, speaking their own language and adhering to their own specific religious and cultural customs. This also holds true for their traditional medical customs which are based on Jamu, the centuries-old traditional form of medicine from Indonesia that mainly involves the use of plants with medicinal properties. The first part of this chapter gave some background on Suriname; then addressed some of the religious and cultural expressions of Surinamese Javanese; focused on Jamu, and concluded with an extensive account of the traditional, phytochemical, and pharmacological aspects of four medicinal plants that are mainly used by Surinamese Javanese. This second part of the chapter continues with a comprehensive narrative about six additional popular ‘Javanese’ medicinal plants and concludes with the contribution of the Javanese pharmacognostic knowledge to Suriname’s traditional medicinal pharmacopeia.
2. Plants used in Javanese pharmacognosy
Hereunder, six medicinal plants that are traditionally mainly used by Surinamese Javanese - in addition to four that have been addressed in the first part of this chapter - have in detail been assessed for their phytochemical contents and pharmacological activities in order to provide a scientific rationale for their ethnopharmacological applications. The plants have been selected on the basis of the number of times they have been dealt with in a number of comprehensive publications describing the use of medicinal plants in the country [4, 5, 6, 7, 8, 9, 10, 11, 12]. All the ten plants and their main traditional use by Surinamese Javanese have been given in Table 1.
Family
Species (vernacular names in English; Surinamese-Javanese)
Part(s) used
Traditional indications
References
Acanthaceae
Strobilanthes crispa Blume (black face general; ketji beling)
Leaf
Disorders of the urinary system, diabetes mellitus
Plants commonly used in Javanese traditional medicine addressed in this chapter, parts preferentially used, and traditional indications in the Surinamese-Javanese community.
2.1 Asteraceae - Ageratum conyzoides L. 1753 not Hieron. 1895 nor Sieber ex Steud. 1840
The goat weed A. conyzoides, called wedusan in Surinamese-Javanese (Figure 1), is an annual herb that is native to northern Brazil. It is sometimes grown as an ornamental plant but has become a common invasive weed in many tropical regions in the Americas, the Caribbean, and Africa. It grows to a height of about 1 meter, has an erect stem covered with white hairs, carries leaves and flowers that emit a strong, unpleasant smell, and is commonly found in gardens and open spaces. The pungent smell from the leaf and flower is due to the presence of an essential oil with a strong nauseating odor [13]. Nevertheless, a decoction of fresh shoots and leaves is used as an ingredient of an ‘anti-ageing’ herbal shampoo [14]. A. conyzoides produces hepatotoxic pyrrolizidine alkaloids [15] that are regularly encountered as contaminants in, among others, grains, honey, milk, organ meats, and eggs [16]. For this reason, A. conyzoides is not consumed by humans except when taken for medicinal purposes.
Figure 1.
The goat weed Ageratum conyzoides L. 1753 not Hieron. 1895 nor Sieber ex Steud. 1840 (Asteraceae) (from: https://images.app.goo.gl/1tsLVnadhCW6kXSr6).
In Suriname, an infusion from the whole plant is drunk against a sore throat, colics, and atony of the digestive tract [11], as well as gynecological diseases and gonorrhea [9]. A tea prepared from the root as well as the juice from the leaf are also used against a sore throat and, in addition, for reducing fever and fighting colds [12]. Itching all over the body, diarrhea, and chest conditions are treated by drinking a tea from the leaves [6]. A concentrated leaf decoction is used against chiggers [17], the juvenile forms of a type of mite (Trombiculidae) that are also known as berry bugs and that produces itching and blisters on the skin [18]. An infusion from the leaves is externally used against allergic conjunctivitis [6]. And a paste from the crushed leaves is applied on abscesses or burn wounds [6].
Most of the traditional uses and supporting pharmacological activities of A. conyzoides have been attributed to its essential oil [19]. The oil contains monoterpenes and sesquiterpenes that are mainly responsible for its fragrance [19], as well as important bioactive constituents such as flavonoids, alkaloids, steroids, benzofurans, tannins, chromenes, and coumarins [19]. A number of alkaloids and flavonoids have been encountered in other parts of the plant [19]. Several of these compounds may be associated with some its traditional uses and pharmacological activities.
The use of preparations from A. conyzoides against a sore throat, fever, and colds [11, 12] may have its rationale in the analgesic, antiinflammatory, antimicrobial, and wound healing activities of the plant. Evidence for analgesic activity was provided by the inhibitory effects of aqueous and ethanolic whole-plant or leaf extracts on acetic acid-induced writhing and/or formalin-induced licking in laboratory rodents, and the increase in the threshold of pain the animals experienced on a hot plate [20, 21]. Notably, an aqueous extract of the whole plant had been reported to accomplish analgesic effects and improvements in articulation mobility in patients with arthrosis [22]. The antinociceptive effects of A. conyzoides might be due to saponins and/or flavonoids in the plant [20, 23].
Indications for antiiflammatory effects of A. conyzoides came from the significant reduction in carrageenin-induced hind paw edema in rats by methanolic and ethanolic root, whole-plant, aerial, and leaf extracts of the plant [21, 23]. A leaf extract also exerted antiinflammatory effects in cotton pellet-induced granuloma and formaldehyde-induced arthritis models of inflammation in rats [24]. The antiinflammatory activity of A. conyzoides might be attributed to certain flavonoids [25]. This supposition is based on the amplification of the inhibitory effect of a methanol extract of the aerial part of the plant on the carrageenan-triggered edema in rats by a flavonoid fraction [25].
Support for antimicrobial activities of A. conyzoides was provided by the broad activity of aqueous, methanolic, and ethanolic extracts from the leaf and the whole plant as well as the essential oil of the plant against both Gram-positive and Gram-negative pathogenic bacteria [26, 27]. The plant extracts were also active against bacteria from wound isolates [28], methicillin-resistant Staphylococcus aureus [29], and clinical isolates of Helicobacter pylori [30]. Furthermore, the essential oil exhibited meaningful fungitoxic effects [26, 31] including activity against Microsporum gypseum, the causative agent of ringworm [32], Candida spp. [26], and the aflatoxin B1-producing Aspergillus flavus [33]. That A. conyzoides may possess, in addition, would healing properties, has been suggested by the improved rates of epithelialization and wound contraction as well as the increased tensile strength of open excision wounds in Wistar rats accomplished by aqueous, methanolic, and ethanolic extracts of the leaf [34].
The analgesic, antiinflammatory, antimicrobial, and wound healing properties of A. conyzoides may also (partially) explain the traditional use of leaf preparations against burning eyes and skin lesions [6], itchy skin [6, 11], gonorrhea [9] as well as against gastrointestinal disorders caused by infectious microorganisms [6, 11]. The latter use is further supported by the in vitro schistosomicidal effect of the essential oil of the plant against the blood fluke Schistosoma mansoni [35]; the protective activity of aqueous and ethanolic leaf extracts against ethanol-induced gastric lesions in rats [36]; and the spasmolytic effect of an aqueous leaf extract on isolated rat intestine smooth muscles [37].
2.2 Caesalpiniaceae - Tamarindus indica L.
The tamarind T. indica, called asem in Surinamese-Javanese (Figure 2), is a long-lived, slow-growing, evergreen tree that can reach a height of 20 meters. The plant has a dense, spreading crown and an extensive root system that makes it very tolerant of windy conditions and drought. Its origin is uncertain but is thought to lie in tropical Africa. From there, it has long ago been introduced in more than fifty tropical and subtropical parts throughout the world. T. indica has fragrant flowers and is extensively cultivated for its edible, sweet–sour-tasting seedpods due to their relatively high concentrations of tartaric acid and reducing sugars. The pods, along with the young leaves, seedlings, and flowers, are extensively used for preparing a large variety of dishes, beverages, and confections, and the dried seeds can be roasted and ground as a coffee substitute.
Figure 2.
The tamarind Tamarindus indica L. Caesalpiniaceae (from: https://images.app.goo.gl/ViLrKniuZfAGExDb7).
T. indica also has a wide range of medicinal applications in various traditional systems throughout Asia, Africa, and the Americas. The plant has presumably been introduced in Suriname by enslaved Africans who used it to fight fever, diarrhea, and worm infections on board of the slave ships [11]. Since then, it is abundantly used medicinally in this country. Javanese use the leaves, together with the rhizomes from Curcuma spp., in various health-promoting jamus, and drink an infusion from the fruit pulp to ease menstrual pain and vaginal discharge [8]. The pulp is used for treating constipation as well as skin conditions, heartburn, and jaundice [4]. Preparations from the leaf are drunk to stimulate perspiration in patients with fever [4] and in herbal baths to ease itching and skin irritation caused by measles, chicken pox, or rubella [12]. And Maroon women who have recently given birth incorporate T. indica leaves in a hot steam bath to cleanse the uterus and the vagina [12], presumably because of the presence of astringent, antimicrobial, and wound healing properties of the tannins in the plant [38].
T. indica contains a variety of phytochemicals with nutritious and pharmacological properties which can account, at least partially, for the traditional uses of the plant and for the pharmacological studies supporting these uses [39]. Important bioactive constituents in the plant are terpenoids and phenolic compounds including tannins; citric, malic, and tartaric acid; pectin and various pentoses and hexoses; many essential dietary minerals; as well as amino acids and proteins [39].
The incorporation of T. indica parts in jamus for improving well-being [35] may be associated with its antioxidant, weight-reducing, and immunomodulatory properties. Evidence for the former property was provided by the potent antioxidant activity exhibited by seed, pericarp, and fruit pulp preparations in various in vitro assays [40, 41, 42], and the improved efficiency of the antioxidant defense system in hypercholesterolemic hamsters treated with an ethanolic extract of the seed coat [41]. The antioxidant activity could be attributed to the polyphenolic compounds such as proanthcyanidins in the preparations [40, 42].
Indications for weight-reducing properties of T. indica came from the hypolipidemic and antioxidant activities of the fruit pulp or a fruit extract in rats on a cholesterol-rich diet [41] and the hypolipidemic and slimming effects of an ethanolic fruit pulp extract in obese rats on a cafeteria diet or on sulpiride (an antipsychotic drug that causes weight gain) [43]. And suggestions for immunomodulatory activity of T. indica were given by the stimulatory effects of a polysaccharide isolated from the fruit pulp on the uptake of foreign bodies by phagocytes, the promotion of lymphocyte proliferation, and the inhibition of leukocyte proliferation in vitro [44], as well as the increase in total white blood cell count, CD4+ T-cell population, and bone marrow cellularity in BALB/c mice which had receiving the polysaccharide intraperitoneally [45].
The use of T. indica against skin lesions [12] as well as menstrual pain and vaginal discharge [8] may be accounted for by the analgesic, antiinflammatory, and antimicrobial properties of the plant. Indications for both former activities came from the increase in reaction time of laboratory rodents in a tail immersion, acetic acid-induced writhing, tail flicking, and hot-plate assay, and the reduction in carrageenan-induced hind paw edema in the animals accomplished by a petroleum ether stembark extract, an aqueous fruit extract, a hydroethanolic leaf extract, and a methanolic seed extract [46, 47]. Evidence for antimicrobial activity came from the broad in vitro antibacterial and antifungal activity of preparations from various parts of the plant [48, 49, 50]. The analgesic and antiinlammatory activities of T. indica have been attributed to sterols, triterpenes, and phenolic compounds in the plant [46, 47]. The antimicrobial activities have mainly been associated with phenolic compounds and the essential oil [48].
Further support for the traditional uses of T. indica mentioned in the preceding alinea lesions [12] are its antihistaminic potential as suggested by the inhibitory effects of a leaf methanolic extract on the histamine-induced contraction of goat tracheal chain and guinea pig ileum [51], and its wound healing activity, as indicated by the accelerated wound closure, epithelial migration, and re-epithelialization of various types of wounds in laboratory rodents caused by water and methanolin seed extracts seed [52], the fruit paste [53], and the cork and seed ash [54].
The claims of efficacy of T. indica against gastrointestinal problems [4] is supported by the efficacy of preparations from the fruit pulp against constipation [55] due to the presence of relatively high amounts of tartaric acid and malic acid in their salt form which improve the movement of the bowel and act as a mild laxative [38]. Furthermore, a methanolic seed coat extract elicited meaningful antiulcer effect on ibuprofen-, alcohol-, and pyloric ligation-induced gastric lesions in rats when compared to the antipeptic agent ranitidine [56]. Finally, the use of T. indica against fevers [4] is supported by the antipyretic activity of a water-soluble crude polysaccharide fraction from the fruit pulp against the raised body temperature in rats and mice which had subcutaneously been injected with yeast or intraperitoneally with a lipopolysaccharide (LPS) from Escherichia coli, respectively [57].
2.3 Fabaceae - Sesbania grandiflora (L.) Poiret
The vegetable hummingbird S. grandiflora, known as turi in Surinamese-Javanese (Figure 3), is a fast-growing, relatively short-lived, highly branched tree that can grow to about 4 meters tall, and has rounded leaves, white, red, or pink flowers, as well as flat, long, thin, and green bean-like fruits. The plant probably originates from Indonesia and/or Malaysia, but is abundantly found in other hot and humid locations throughout the world. It is cultivated in various countries for its many edible parts. S. grandiflora also has many traditional medicinal uses in various parts of the world [58]. In Suriname, the plant is mainly used by Javanese, who cook the flowers, leaves, and young pods and eat them as a vegetable [12]. They also prepare a tea from the astringent bark for treating abdominal disorders and use the leaf juice as a gargle against a sore throat and mouth sprue [12].
Figure 3.
The vegetable hummingbird Sesbania grandiflora (L.) Poiret (Fabaceae) (from: https://images.app.goo.gl/8oo6WbZ8MJsEr5e2A).
Phytochemical studies revealed the presence of several bioactive in S. grandiflora that may account for its traditional uses including alkaloids, flavonoids, tannins, terpenoids, glycosides, steroids, and saponins [59]. Some of these compounds have been associated with, among others, the antimicrobial, hepatoprotective, antioxidant, and hypolipidemic activities of the plant [60, 61, 62].
Pharmacological support for the use of a concoction from S. grandiflora stembark against gastrointestinal disorders [12] is provided by the preventive action of an ethanolic extract of this part of the plant against acute gastric injury in rats caused by stress or non-steroidal anti-inflammatory drugs [63]. Of note, the extract did not modify the volume, pH, and hydrochloric acid contents of the gastric secretion of the animals [63]. Importantly, ethanolic extracts of the leaf substantially inhibited the development of ulcers in adult albino rats caused by pylorus ligation and ethanol when compared to omeprazole [64]. Furthermore, the seed oil showed considerable anthelmintic activity [65], speaking in favor of its traditional use to expel parasitic worms and other internal parasites from the gastrointestinal tract. Moreover, an S. grandiflora ethanolic leaf extract exerted a substantial protective effect on liver injury in rats produced by the antibiotic erythromycin estolate [61].
The use of the leaf juice against conditions of the throat and the oral cavity [12] may be accounted for by the antibacterial and wound healing activity of this preparation. Support for the former suggestion came from the notable activity of extracts from the leaf - but also from the stembark, the flower, and other parts of the plant - against a variety of bacterial strains [66, 67, 68]. The antimicrobial activity was most prominent with extracts prepared with organic solvents [66, 67, 68] and was also directed against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, either in culture or in silkworms infected with these pathogens [68]. In some cases, the antimicrobial properties of the plant have been associated with the presence of bioactive constituents such as tannins, sterols, saponins, phenolic compounds including flavonoids, and alkaloids [66, 68, 69].
Indications for wound healing activity of S. grandiflora came from the rapid repair of excision and/or incision wounds in Wistar albino rats following the topical application of a methanolic extract of the stembark or an ethanolic extract from the flower when compared to the topical antibiotics framycetin sulphate and nitrofurazone, respectively [70, 71]. Furthermore, the use of a semi-purified extract of the stembark significantly stimulated the healing of incision wounds on the mucosa of the lower lip of rats when compared to the topical antiseptic and disinfectant dequalinium chloride [72]. This activity has been attributed to the astringent and antimicrobial properties of the stembark and has been interpreted as support for the traditional use of the plant against mouth ulcers [72]. As well, an ethanolic extract of S. grandiflora flower showed potent in vitro activity against Streptococcus mutans - that is commonly found in the human oral cavity and is a significant contributor to tooth decay - that was comparable to that of erythromycin [73].
2.4 Portulacaceae - Portulaca oleracea L.
The green purslane P. oleracea, called krokot in Surinamese-Javanese (Figure 4), is an erect annual succulent herb that can reach a height of about 40 centimeters. The origin of this plant is uncertain but may lie in western Asia, India, and/or even Africa. P. oleracea was probably one of the first plants to be domesticated as a food crop. Now, it often grows as a weed in fields, waste grounds, roadside verges, and cultivated grounds in many temperate tropical parts of the world. However, it is among the richest vegetable sources of omega-3 fatty acids and also contains high levels of vitamins C and E, β-carotene, and dietary minerals such as potassium, magnesium, calcium, phosphorus, and iron [74].
Figure 4.
The green purslane Portulaca oleracea L. (Portulacaceae) (from: https://images.app.goo.gl/wmwxjiB8FvgpzF7JA).
P. oleracea has also been used in various folk medicinal systems since ancient times and is still one of the most widely used medicinal plants in the world [75]. In Suriname, individuals from all ethnic groups including those from Javanese ancestry, mainly use preparations from P. oleracea as a dressing on abscesses and sores; as an ointment with coconut oil for sprains, swellings, stiff joints, as well as back and neck pain; to stop bronchitis, and against conjunctivitis [5, 9]. The plant is also widely used against anemia [12] because of its relatively high iron content [74]. Incidentally, administration of P. oleracea seeds to adolescent females with iron deficiency anemia led to appreciable increases in the girls’ hemoglobin, hematocrit, and mean corpuscular volume [76].
Some of the traditional uses may be associated with the presence in the plant of potent bioactive compounds such as flavonoids and alkaloids [77, 78]. Some of the flavonoids have been associated with antibacterial, antiviral, antiinflammatory, and/or antioxidant activities of the plant [77, 78, 79]. Potent alkaloids identified in the plant are dopa, dopamine, and noradrenalin as well as oleracimines which have been associated with the antiinflammatory properties of the plant [77, 78, 80].
The apparent usefulness of P. oleracea as a dressing on abscesses and sores and for treating sprains, swellings, stiff joints, and back and neck pain [12] may be explained by the wound healing, antiinflammatory, analgesic, antioxidant, and/or antimicrobial activity elicited by preparations of parts of the plant. Support for the wound healing-promoting properties of P. oleracea came from the stimulation of contraction, the decrease in surface area, and the increase in tensile strength of excision wounds in mice following topical treatment with an extract of the aerial parts of the plant [81]. An ethanolic extract of the aerial parts of the plant also accelerated the healing of excision wounds in streptozotocin-induced albino rats by stimulating wound contraction and promoting granulation and organization formation [82].
Indications for antiinflammatory and analgesic activities of P. oleraceae were provided by the inhibitory effects of extracts from aerial-parts, leaf, and seed extracts of the plant in the paw edema and ear edema tests, as well as the paw licking, writhing, tail flicking, and hot plate tests [83, 84]. Importantly, intraperitoneal administration of the alkaloid allantoin isolated from the seed gave comparable results [85]. The anti-inflammatory and analgesic efficacies of the plant-derived products were similar to those found with diclofenac and aspirin [83, 84, 85]. Furthermore, aqueous extracts of the dried aerial parts of the plant prevented the TNF-α-induced vascular inflammatory events in cultured human umbilical vein endothelial cells (HUVECs) [86], and substantially inhibited the protein expression of iNOS as well as the production of PGE2, IL-6, and TNF-α in LPS-activated cultured RAW 264.7 murine macrophages [87]. The antiinflammatory activities of the P. oleracea preparations have been attributed to oleracimines, since these compounds inhibited the secretion of various inflammatory mediators by LPS-stimulated macrophages [88].
Indications for antioxidant activity of P. oleracea have been provided by the protective effects of an aerial-parts aqueous extract against DNA strand breakage in human lymphocytes caused by hydrogen peroxide [89], and of aqueous and ethanolic seed extracts against hemolysis of erythrocytes caused by the free radical initiator 2,2′-azobis hydrochloride [90]. Furthermore, administration of leaf and stem preparations prevented oxidative damage in the liver of laboratory mice treated with steptozotocin [79] or fed with a high-fat diet, among others, by modulating blood and liver antioxidant enzyme activities [91]; increased the levels of reduced glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase and glutathione peroxidase, and inhibited lipid peroxidation and nitric oxide in liver, kidney, and testis of male Wistar albino rats [92]; and improved serum levels of superoxide dismutase and catalase in sensitized rats [93]. The latter results were also achieved with the use of α-linolenic acid, one of the constituents of the leaf and stem of the plant [93].
P. oleracea probably also possesses antibacterial, antifungal, and antiviral activities. These suppositions are supported by the growth-inhibitory activity of extracts of the leaf and stem against a wide range of both Gram-negative and Gram-positive pathogenic bacteria [94, 95] as well as Candida albicans [94]. An ethyl acetate extract of the aerial parts of the plant also inhibited the growth of dermatophytes of the genera Trichophyton [96]. And a polysaccharide isolated from the aerial part of the plant was active against herpes simplex virus type 2 [97] and a methanolic extract of the aerial parts against hepatitis C virus genotype-3a infected in cultured Huh-7 human liver cells [98]. The apparent antiviral activities of P. oleracea, along with the above-mentioned antibacterial and antifungal properties of the plant may account for its traditional use in Suriname against conjunctivitis [5] and bronchitis [9].
2.5 Zingiberaceae - Curcuma longa L.
The turmeric C. longa, known as kunjit in Surinamese-Javanese (Figure 5), is an erect, herbaceous, perennial plant that grows to a height of about 1.5 meters. It is believed to have arisen in southern or south-eastern Asia by selection and vegetative propagation of a hybrid between the wild turmeric Curcuma aromatica Salisb. and other closely related species. As a result, C. longa is not found in the wild and is only known as a domesticated plant. The maternal plant carries yellow-white flowers that do not produce viable seed and multiplies by producing new sprouts from its underground rhizomes. The plant is abundantly cultivated for its pulpy orange-yellow rhizome in Indonesia and India as well as many other tropical and subtropical parts of the world. The pungent and bitter-tasting rhizome is dried and ground into a yellow powder, an essential ingredient of curry powders and pastes for coloring and flavoring many meat and fish dishes in Asian cuisine and as a bright yellow constituent that is used in the food industry as a natural food colorant.
Figure 5.
The turmeric Curcuma longa L. (Zingiberaceae) (from: https://images.app.goo.gl/1QbEoBg45CR8ub2m6).
C. longa preparations have also a centuries-long medicinal use in various traditional systems, particularly in Indonesian Jawa and Indian Ayurveda, Unani, and Siddha [99]. In Suriname, C. longa rhizome is an essential ingredient of many jamus to promote health and fitness and to enhance mental functioning and well-being, as well as in jamus for treating inflamed gums, abscesses, menstrual pains, and skin rash [8]. In addition, drinking a tea from the fresh rhizome would purify the blood and treat stomach pain, chewing on the fresh rhizome and swallowing the sap would help against diarrhea, drinking the sap mixed with chalk would help against menstrual pains, and having children drink the sap of the grated rhizome mixed with that of other plants would take care of pinworm infection [12]. Moreover, the sap from the fresh rhizome is rubbed on the abdomen to ease bellyache and fever, dripped on watering eyes and inflamed eyelids, and used to disinfect pierced ears and the navel of newborn babies [12].
The main constituents of C. longa rhizome that may be associated with these beneficial effects are polyphenolic compounds such as diarylheptanoids and diarylpentanoids, as well as terpenoids such as sesquiterpenes, monoterpenes, diterpenes, and triterpenoids [100, 101]. The most common diarylheptanoids are the yellow-colored curcuminoids curcumin along with its derivatives demethoxycurcumin and bisdemethoxycurcumin [100, 101]. These constituents impart the characteristic color and flavor to preparations from this part of the plant [100, 101]. The sesquiterpenes are the main constituents of the rhizome essential oil, while the monoterpenes dominate the essential oils from the leaves and the flowers [101]. The major volatile principles of the rhizome oil are the aromatic compounds α- and β-turmerone [101].
Several lines of evidence support the inclusion of C. longa rhizome in jamus to promote health and fitness and to enhance mental functioning and well-being [8]. Firstly, rhizome preparations reduced the deposition of plaques similar to those seen in Alzheimer’s disease in the brains of aged mice and the oxidative damage and amyloid pathology in transgenic mouse models of Alzheimer’s disease [102]. Secondly, curcumin therapy produced favorable responses in a transgenic mouse model of Alzheimer’s disease [103], and both curcumin and dimethoxycurcumin lessened lead-induced memory deficits in Wistar rats [104]. Furthermore, a water extract of the rhizome exerted anti-stress effects in laboratory rats which were comparable to those caused by the antidepressant fluoxetine [105]. Importantly, the results from clinical studies suggested that the daily intake of this extract had a positive influence on emotional fatigue in healthy individuals [106], that curcumin intake reduced fatigue, tension, anger, confusion, and total mood disturbance following 4 weeks of supplementation in non-depressed healthy elderly people [107, 108], and that curcumin reduced depressive symptoms in individuals suffering from depression [109].
The usefulness of C. longa against (inflammatory) gastrointestinal conditions [12] is sustained by the inhibitory effects of curcumin on the damage caused by indomethacin to the gastric mucosa of laboratory rats [110] and the production of inflammatory cytokines, intercellular adhesion molecule 1, and TNF-α in the animals [110]. Furthermore, curcumin substantially improved the profile of inflammatory markers, severity of diarrhea, and colonic architecture in laboratory mice with colitis induced by trinitrobenzenesulfonic acid [111]. Clinical trials indeed showed beneficial effects of curcumin or a standardized C. longa rhizome extract in patients with peptic ulcers [112] or inflammatory bowel disease [113]. In fact, a Cochrane analysis revealed that curcumin may be a safe and effective therapy for the maintenance of remission in quiescent ulcerative colitis [114].
These apparent antiinflammatory activities of C. longa also support its traditional use against primary dysmenorrhea [12]. The substantial reduction in the level of pain during menstruation accomplished by rhizome preparations in various clinical studies (see, for instance, ref. [115]) was presumably due to blockade of prostaglandin production by curcumin [116], producing analgesic and antiinflammatory effects [116, 117]. The same mechanisms may be involved in the apparent beneficial effects of C. longa preparations against inflamed gums, abscesses, pain, inflammatory skin conditions, and conjunctivitis [8], as well as the application of a C. longa-based Javanese ointment called bobok for alleviating the discomfort of, among others, toothache [8].
The aseptic properties of C. longa may contribute to these effects. Indeed, both rhizome preparations and curcumin inhibited the growth of various standard bacterial strains [118, 119] including common periopathogens [120], as well as pathogenic fungi such as Candida albicans [121] and Aspergillus flavus [122]. Curcumin and its derivatives were also active against a broad variety of pathogenic viruses [123] including the influenza virus [124], accounting for its traditional use for fighting fever [12]. Finally, the broad antiparasitic activity of curcumin [125] may explain the Surinamese-Javanese custom of including C. longa rhizome in preparations for treating pinworm infection in children [8].
2.6 Zingiberaceae - Zingiber officinale Roscoe
The ginger Z. officinale, called djahe in Surinamse-Javanese (Figure 6), is a slender, erect, herbaceous perennial plant that grows to a height of about 2 meters. It has a thick, branched rhizome that grows horizontally near the soil surface and gives rise to leafy shoots that grow close together. Z. officinale has a long history of cultivation and use, with records going back almost 2,000 years [126]. It has probably first been domesticated in tropical Asia, presumably China, and is believed to have spread via south-eastern Asia and Africa to the Neotropics. In all these parts of the world it is abundantly cultivated for its succulent, aromatic, and pungent rhizome. This part of the plant is widely used as a hot, spicy flavoring for a variety of oriental dishes, as well as cakes, candies, and hot and cold beverages. Z. officinale also has a very long use as a medicinal herb in many traditional systems, particularly those from Indonesia, India, and China, where the fresh or dried rhizome and the essential oil are ingredients of numerous medicaments [127].
Figure 6.
The ginger Zingiber officinale Roscoe Zingiberaceae (from: https://images.app.goo.gl/ETuwvyrgdVMDP5eY9).
Z. officinale has probably been introduced in Suriname by Javanese indentured laborers [8]. The rhizome is an ingredient of many health-promoting jamus including those for maintaining the functioning of heart, muscles, blood vessels, and intestines, as well as those to stimulate fertility, reduce the risk of diabetes mellitus, and decrease stress [8]. Furthermore, all ethnic groups in Suriname also use Z. officinale rhizome for treating coughing, influenza, cold, sore throat, hoarseness, laryngitis, and pneumonia; stomach cramps and other abdominal problems; overweight; menstrual pain and to cleanse the uterus after delivery; and externally to massage bruised limbs, rheumatic joints, and sore muscles [12].
The distinctive odor and flavor of Z. officinale rhizome is mainly the result of a combination of volatile oils and non-volatile phenolic compounds [128]. The volatile oils predominantly consist of zingiberol and other sequiterpene hydrocarbons [128], while the non-volatile phenolic phytochemicals comprise, among others, gingerols, shogaols and paradols [128]. Gingerols, including 6-gingerol - the best studied phytochemical in Z. officinale - are the major pungent compounds in the fresh rhizome [128]. The gingerols are thermally labile and easily undergo dehydration reactions during drying, heating, or prolonged storage of the rhizome to form the corresponding shogaols which are about twice as pungent as the gingerols [128].
Both gingerols and shogaols exhibit a host of biological activities [129, 130], supporting some of the traditional claims of Z. officinale [8, 12]. The incorporation of Z. officinale in many health-promoting jamus [8] may be related to the ameliorating effects of the essential oil on the antioxidant capacity, inflammatory response, and the building up of fat in the liver in cases of high-fat diet-induced non-alcoholic fatty liver disease [131]. The antioxidant compounds in Z. officinale rhizome are primarily gingerols, shogaols, and some related diarylheptanoids [132], and may help protect the cells from oxidative stress [133]. In addition, Z. officinale preparations accomplished hypocholesterolemic, hypolipidemic, and antiatherosclerotic effects in cholesterol-fed rabbits and rats [134] and inhibited LDL oxidation and attenuated the development of atherosclerosis in apolipoprotein E-deficient mice [133].
Furthermore, crude rhizome methanol extracts elicited potent positive-inotropic effects in an isolated guinea pig left atria preparation [135]. These extract also induced a dose-dependent fall in blood pressure in anesthetized rats, inhibited the spontaneous force and beating rate of atrial contractions in guinea pig atria similarly to the calcium antagonist verapamil, and caused endothelium-independent vasodilation in rabbit and rat aorta [136]. These apparent cardiotonic activities have been ascribed to the gingerols and the shogaols in the preparations [125, 136]. Additional support for the inclusion of Z. officinale rhizome in health-enhancing jamus is provided by the ameliorating activity of 6-gingerol on the genotoxicity (chromosomal aberrations and sister chromatid exchanges) caused in cultured human lymphocyte chromosomes by norethandrolone and oxandrolone [137], and the chemopreventive activities of gingerols and shogaols in animals treated with laboratory carcinogens [138].
The folkloristic use of Z. officinale for treating conditions of the respiratory system is supported by the broad in vitro antibacterial properties of rhizome preparations as well as gingerols against both Gram-positive and Gram-negative human pathogenic bacteria and fungi [139] including those associated with respiratory tract infections [140]; the potentiation of the antibacterial effect of some commonly used antibiotics by the rhizome extract [141]; and the activity of these substances and compounds against the influenza A/Aichi/2/68 virus [142], the human respiratory syncytial virus (HRSV) [143], and the influenza A (H1N1) virus [144].
Several pieces of evidence support the traditional use of Z. officinale against gastrointestinal disorders [12]. Firstly, preparations from the rhizome inhibited the growth of several strains of Helicobacter pylori [145] and improved dyspeptic symptoms in patients with H. pylori-positive functional dyspepsia [146]. Secondly, rhizome preparations had a stimulatory effect on antiinflammatory cytokines and an inhibitory effect on proinflammatory cytokines in inflammations associated with the alimentary channel such as colitis and inflammatory bowel disease [147]. The antiinflammatory activities have been associated with potent inhibitory effects on prostaglandin, thromboxane, and leukotriene biosynthesis [148] and COX-2 activity [149]. Furthermore, methanolic and aqueous extracts from the rhizome exerted meaningful activity against larvae of the rat long worm Angiostrongylus cantonensis and those of the parasitic fish nematode Anisakis simplex, the causative agents of angiostrongyliasis, the most common causes of eosinophilic meningitis or meningoencephalitis in south-eastern Asia and the tropical Pacific islands [150], and anisakiasis, a gastrointestinal infection characterized by severe abdominal cramps [151], respectively. This suggests that Z. officinale also has activity against parasites of the alimentary tract, further supporting its traditional use against conditions of this organ system [12].
3. Concluding remarks
The Javanese have been in Suriname for over a century. They have been brought to that country as poor and unaccustomed indentured laborers but have become successful individuals who have integrated well into the Surinamese community, actively participating in all its sections. Indeed, the Javanese are full-fledged citizens of the country and an integral part of the vibrant color palette represented by its unique cultural, religious, and ethnic diversity. This is reflected by the presence of the small, often family-owned Javanese restaurants called warungs in the smallest of towns, where widely appreciated savory dishes such as bami goreng (fried noodles), nasi goreng (fried rice), pityel (mixed blanched vegetables with a peanut sauce dressing), teloh (fried cassava), pejeh (prawn crackers), and saoto soup (chicken broth, meat, and vegetables) can be enjoyed, and can be washed down with refreshing beverages such as the lemongrass-, corn starch-, and coconut milk-based dawet.
Nevertheless, the Javanese have maintained most of their cultural traditions. This particularly holds true for their ancient form of medicine that is based on centuries-old Jamu. Jamu has added a unique element to the array of traditional forms of medicine throughout the Caribbean and Latin America, most of which are based on practices from the Indigenous American peoples as well as those from Africa, China, India, and various European countries. The influence of Jamu is already noticeable. The use of an infusion of the cat’s whiskers or kumis kutjing Orthosiphon aristatus (Blume) Miq. (Lamiaceae) for treating kidney stones and renal colics is no longer limited to Indonesia and Suriname but has expanded into many other parts of the world. It is foreseeable that many more Jamu recipes will one day contribute to Suriname’s traditional medicinal pharmacopeia as well as to the development of novel mainstream drugs for treating human diseases.
\n',keywords:"Suriname, Javanese, ethnopharmacology, medicinal plants, ethnobotanical uses, phytochemistry, pharmacology",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/76706.pdf",chapterXML:"https://mts.intechopen.com/source/xml/76706.xml",downloadPdfUrl:"/chapter/pdf-download/76706",previewPdfUrl:"/chapter/pdf-preview/76706",totalDownloads:201,totalViews:0,totalCrossrefCites:0,dateSubmitted:null,dateReviewed:"April 15th 2021",datePrePublished:"May 10th 2021",datePublished:"May 11th 2022",dateFinished:"May 10th 2021",readingETA:"0",abstract:"The Republic of Suriname (South America) is among the culturally, ethnically, and religiously most diverse countries in the world. Suriname’s population of about 600,000 consists of peoples from all continents including the Javanese who arrived in the country between 1890 and 1939 as indentured laborers to work on sugar cane plantations. After expiration of their five-year contract, some Javanese returned to Indonesia while others migrated to The Netherlands (the former colonial master of both Suriname and Indonesia), but many settled in Suriname. Today, the Javanese community of about 80,000 has been integrated well in Suriname but has preserved many of their traditions and rituals. This holds true for their language, religion, cultural expressions, and forms of entertainment. The Javanese have also maintained their traditional medical practices that are based on Jamu. Jamu has its origin in the Mataram Kingdom era in ancient Java, some 1300 years ago, and is mostly based on a variety of plant species. The many Jamu products are called jamus. The first part of this chapter presented a brief background of Suriname, addressed the history of the Surinamese Javanese as well as some of the religious and cultural expressions of this group, focused on Jamu, and comprehensively dealt with four medicinal plants that are commonly used by the Javanese. This second part of the chapter continues with an equally extensive narrative of six more such plants and concludes with a few remarks on the contribution of Javanese jamus to Suriname’s traditional medicinal pharmacopeia.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/76706",risUrl:"/chapter/ris/76706",signatures:"Dennis R.A. Mans, Priscilla Friperson, Meryll Djotaroeno and Jennifer Pawirodihardjo",book:{id:"11752",type:"book",title:"Natural Drugs from Plants",subtitle:null,fullTitle:"Natural Drugs from Plants",slug:"natural-drugs-from-plants",publishedDate:"May 11th 2022",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-80356-021-2",printIsbn:"978-1-80356-020-5",pdfIsbn:"978-1-80356-022-9",isAvailableForWebshopOrdering:!0,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"193905",title:"Dr.",name:"Dennis",middleName:"R. A.",surname:"R.A. Mans",fullName:"Dennis R.A. Mans",slug:"dennis-r.a.-mans",email:"dennismans16@gmail.com",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/193905/images/system/193905.png",institution:{name:"Anton de Kom University of Suriname",institutionURL:null,country:{name:"Suriname"}}},{id:"415888",title:"Dr.",name:"Priscilla",middleName:null,surname:"Friperson",fullName:"Priscilla Friperson",slug:"priscilla-friperson",email:"dummy+415888@intechopen.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"415889",title:"Dr.",name:"Meryll",middleName:null,surname:"Djotaroeno",fullName:"Meryll Djotaroeno",slug:"meryll-djotaroeno",email:"dummy+415889@intechopen.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"415890",title:"Dr.",name:"Jennifer",middleName:null,surname:"Pawirodihardjo",fullName:"Jennifer Pawirodihardjo",slug:"jennifer-pawirodihardjo",email:"dummy+415890@intechopen.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Plants used in Javanese pharmacognosy",level:"1"},{id:"sec_2_2",title:"2.1 Asteraceae - Ageratum conyzoides L. 1753 not Hieron. 1895 nor Sieber ex Steud. 1840",level:"2"},{id:"sec_3_2",title:"2.2 Caesalpiniaceae - Tamarindus indica L.",level:"2"},{id:"sec_4_2",title:"2.3 Fabaceae - Sesbania grandiflora (L.) Poiret",level:"2"},{id:"sec_5_2",title:"2.4 Portulacaceae - Portulaca oleracea L.",level:"2"},{id:"sec_6_2",title:"2.5 Zingiberaceae - Curcuma longa L.",level:"2"},{id:"sec_7_2",title:"2.6 Zingiberaceae - Zingiber officinale Roscoe",level:"2"},{id:"sec_9",title:"3. Concluding remarks",level:"1"}],chapterReferences:[{id:"B1",body:'General Bureau of Statistics. Demographic data 2015-2018. Paramaribo: General Bureau of Statistics; 2019.'},{id:"B2",body:'Hoefte R. In place of slavery: a social history of British Indian and Javanese laborers in Suriname. Gainesville: University Press of Florida; 1998.'},{id:"B3",body:'Djasmadi L, Hoefte R, Mingoen H, editors. Migratie en cultureel erfgoed: verhalen van Javanen in Suriname, Indonesië en Nederland (Migration and cultural heritage: stories of Javanese in Suriname, Indonesia and The Netherlands). Leiden: KITLV Press; 2010.'},{id:"B4",body:'Stephen HJM. Geneeskruiden van Suriname: hun toepassing in de volksgeneeskunde en in de magie (Herbal medicines from Suriname: their applications in folk medicine and wizardry). Amsterdam: De Driehoek; 1979.'},{id:"B5",body:'Wooding CJ. Traditional healing and medicine in Winti: a sociological interpretation. Journal of Opinion. 1979;9:35-40.'},{id:"B6",body:'May AF. Sranan oso dresi. Surinaams kruidenboek (Surinamese folk medicine. A collection of Surinamese medicinal herbs). Paramaribo: De Walburg Pers; 1982.'},{id:"B7",body:'Titjari. Famiri-encyclopedia foe da natoera dresi-fasi. Gezinskruidenboek van de natuurgeneeswijzen. Natuurgeneeswijzen uit het zonnige Suriname (Encyclopedia of plant-based forms of treatment. Folk medicines from sunny Suriname). Amsterdam: Sangrafoe; 1985.'},{id:"B8",body:'Tjong Ayong G. Het gebruik van medicinale planten door de Javaanse bevolkingsgroep in Suriname (The use of medicinal plants by the Javanese in Suriname). Paramaribo: Instituut voor de Opleiding van Leraren; 1989.'},{id:"B9",body:'Sedoc NO. Afrosurinaamse natuurgeneeswijzen: bevattende meer dan tweehonderd meest gebruikelijke geneeskrachtige kruiden (Afro-Surinamese natural remedies: over two hundred commonly used medicinal herbs). Paramaribo: Vaco Press; 1992.'},{id:"B10",body:'Raghoenandan UPD. Etnobotanisch onderzoek bij de Hindoestaanse bevolkingsgroep in Suriname (An ethnobotanical investigation among Hindustanis in Suriname). [MSc thesis]. Paramaribo: Anton de Kom Universiteit van Suriname; 1994.'},{id:"B11",body:'DeFilipps R, Maina S, Crepin J, National Museum of Natural History (US), Department of Botany. Medicinal plants of the Guianas (Guyana, Surinam, French Guiana). Washington DC: Dept. of Botany, National Museum of Natural History, Smithsonian Institution; 2004.'},{id:"B12",body:'Van Andel TR, Ruysschaert S. Medicinale en rituele planten van Suriname (Medicinal and ritual plants of Suriname). Amsterdam: KIT Publishers; 2011.'},{id:"B13",body:'Wandji J, Bissangou MF, Ouambra JM, Silou T, Abena AA, Keita A. The essential oil from Ageratum conyzoides. Fitoterapia. 1996;67:427-431.'},{id:"B14",body:'Singh SR, Phurailatpam AK, Senjam P. Identification of the plants use as natural herbal shampoo in Manipur. African Journal of Traditional, Complementary and Alternative Medicine. 2014;11:135-139.'},{id:"B15",body:'Neuman MG, Cohen L, Opris M, Nanau RM, Hyunjin J. Hepatotoxicity of pyrrolizidine alkaloids. Journal of Pharmacy and Pharmaceutical Sciences. 2015;18:825-843.'},{id:"B16",body:'Griffin CT, Sheehan A, Danaher M, Furey A. Pyrrolizidine alkaloids in food: Analytical, toxicological and health considerations. In: Wong Y-C, Lewis RJ, editors. Analysis of food toxins and toxicants. 2017. p. 267-318.'},{id:"B17",body:'Diallo BO, Joly HI, McKey D, Hosaert-McKey M, Chevallier MH. Genetic diversity of Tamarindus indica populations: Any clues on the origin from its current distribution? African Journal of Biotechnology. 2007;6:853-860.'},{id:"B18",body:'Elston DM. What’s eating you? Chiggers. Cutis. 2006;77:350-352.'},{id:"B19",body:'Singh SB, Devi WR, Marina A, Devi WI, Swapana N, Singh CB. Review: Ethnobotany, phytochemistry and pharmacology of Ageratum conyzoides Linn (Asteraceae). Journal of Medicinal Plant Research. 2013;7:371-385.'},{id:"B20",body:'Okemy-Andissa N, Ouamba JM, Koudou J, Diatewa M, Gleassor H, Abena AA. Comparative study of analgesic activities of Tetra® and an association of three plants: Ageratum conyzoides, Cymbopogon citratus and Lippia multiflora. International Journal of Pharmacology. 2006;2:42-44. DOI: 10.3923/ijp.2006.42.44.'},{id:"B21",body:'Rahman MA, Akter N, Rashid MH, Nazim A, Uddin M, Islam M. Analgesic and anti-inflammatory effect of whole Ageratum conyzoides and Emilia sonchifolia alcoholic extracts in animal models. African Journal of Pharmacy and Pharmacology. 2012;6:1469-1476. DOI: 10.5897/AJPP12.083.'},{id:"B22",body:'Marques-Neto JF, Lapa A, Kubota M. Efeitos do Ageratum conyzoides Linee no tratamento da artrose (Effects of Ageratum conyzoides Linn, on the treatment of arthrosis). Revista Brasileira de Reumatologia. 1988;28:34-37.'},{id:"B23",body:'Sampson JH, Phillipson JD, Bowery NG, OíNeill MJ, Houston JG, Lewis JA. Ethnomedicinally selected plants as sources of potential analgesic compounds: Indication of in vitro biological activity in receptor binding assays. Phytotherapy Research. 2000;14:24-29.'},{id:"B24",body:'Moura AC, Silva EL, Fraga MC, Wanderley AG, Afiatpour P, Maia MB. Anti-infl ammatory and chronic toxicity study of the leaves of Ageratum conyzoides L. in rats. Phytomedicine. 2005;12:138-142.'},{id:"B25",body:'Galati EM, Miceli N, Taviano MF, Sanogo R, Raneri E. Anti-inflammatory and antioxidant activity of Ageratum conyzoides. Pharmaceutical Biology. 2001;39:336-339. DOI: 10.1076/phbi.39.5.336.5891.'},{id:"B26",body:'Pattnaik S, Subramayam V, Perumal SR, Igancimuthu S, Patric RD. Preliminary screening of ethnomedicinal plants from India. Journal of Ethnopharmacology. 1999;66:235-290.'},{id:"B27",body:'Neelabh C, Nahid A, Navneet K. Study on methanolic extract of Ageratum conyzoides for its ability to act as an antioxidant and to suppress the microbial growth. The Pharma Innovation Journal. 2017;6:170-173.'},{id:"B28",body:'Odeleye OP, Oluyege JO, Aregbesola OA, Odeleye PO. Evaluation of preliminary phytochemical and antibacterial activity of Ageratum conyzoides (L) on some clinical bacterial isolates. International Journal of Engineering and Science. 2014;3:1-5.'},{id:"B29",body:'Akinyemi KO, Oladapo O, Okwara CE, Ibe CC, Fasure K.A. Screening of crude extracts of six medicinal plants used in South- West Nigerian unorthodox medicine for antimethicillin resistant Staphylococcus aureus activity. BMC Complementary and Alternative Medicine. 2005;5:6-8.'},{id:"B30",body:'Roland NN, Alertia EMT, Susan MM, Henry NL, Agnes M, Lucy MN, et al. In vitro anti-Helicobacter pylori activity of extracts of selected medicinal plants from North West Cameroon. Journal of Ethnopharmacology. 2007;114:452-457. DOI: 10.1016/j.jep.2007.08.037.'},{id:"B31",body:'Fiori ACG, Schwan-Estrada KRF, Stangarlin JR, Vida JB, Scapim CA, Cruz MES, et al. Antifungal activity of leaf extracts and essential oils of some medicinal plants against Didymella bryoniae. Journal of Phytopathology. 2000;148:483-487. DOI: 10.1046/j.1439-0434.2000.00524.x.'},{id:"B32",body:'Mishra DN, Dixit V, Mishra AK. Mycotoxic evaluation of some higher plants against ringworm causing fungi. Indian Drugs. 1991;28:300-303.'},{id:"B33",body:'Nogueira JH, Gonçalez E, Galleti SR, Facanali R, Marques MO, Felício JD. Ageratum conyzoides essential oil as aflatoxin suppressor of Aspergillus flavus. International Journal of Food Microbiology. 2010;137:55-60. DOI: 10.1016/j.ijfoodmicro.2009.10.017.'},{id:"B34",body:'Dash G, Pn M. Wound healing effects of Ageratum conyzoides Linn. International Journal of Pharma and Bio Sciences. 2011;2:369-383.'},{id:"B35",body:'De Melo NI, Magalhaes LG, de Carvalho CE, Wakabayashi KA, de P Aguiar G, Ramos RC, et al. Schistosomicidal activity of the essential oil of Ageratum conyzoides L. (Asteraceae) against adult Schistosoma mansoni worms. Molecules. 2011;16:762-773. DOI: 10.3390/molecules16010762.'},{id:"B36",body:'Shirwailkar A, Bhilegaonkar PM, Malini S, Kumar JS. The gastroprotective activity of the ethanol extract of Ageratum conyzoides. Journal of Ethnopharmacology. 2003;86:117-121. DOI: 10.1016/S0378-8741(03)00050-3.'},{id:"B37",body:'Silva MJMe, Capaz FR, Vale MR. Effects of the water soluble fraction from leaves of Ageratum conyzoides on smooth muscle. Phytotherapy Research. 2000;14:130-132. DOI: 10.1002/(SICI)1099-1573(200003)14:2<130::AID-PTR594>3.0.CO;2-4.'},{id:"B38",body:'Havinga RM, Hartl A, Putscher J, Prehsler S, Buchmann C, Vogl CR. Tamarindus indica L, (Fabaceae): Patterns of use in traditional African medicine. Journal of Ethnopharmacology. 2010;127:573-588. DOI: 10.1016/j.jep.2009.11.028.'},{id:"B39",body:'Ahmad A, Ahmad W, Zeenat F, Sajid M. Therapeutic, phytochemistry and pharmacology of Tamarindus indica: A review. International Journal of Unani and Integrative Medicine. 2018;2:14-19.'},{id:"B40",body:'Sudjaroen Y, Haubner R, Wurtele G, Hull WE, Erben G, Spiegelhalder B, et al. Isolation and structure elucidation of phenolic antioxidants from tamarind (Tamarindus indica L.) seeds and pericarp. Food and Chemical Toxicology. 2005;43:1673-1682.'},{id:"B41",body:'Martinello F, Soares SM, Franco JJ, Santos AC, Sugohara A, Garcia SB, et al. Hypolipemic and antioxidant activities from Tamarindus indica L. pulp fruit extract in hypercholesterolemic hamsters. Food and Chemical Toxicology. 2006;44:810-818.'},{id:"B42",body:'Siddhuraju P. Antioxidant activity of polyphenolic compounds extracted from defatted raw and dry heated Tamarindus indica seed coat. LWT Food Science and Technology. 2007;40:982-990.'},{id:"B43",body:'Jindal V, Dhingra D, Sharma S, Parle M, Harna RK. Hypolipidemic and weight reducing activity of the ethanolic extract of Tamarindus indica fruit pulp extract in cafeteria diet and sulpiride-induced obese rats. Journal of Pharmacology and Pharmacother. 2011;2:80-84. DOI: 10.4103/0976-500X.81896.'},{id:"B44",body:'Sreelekha TT, Vijayakumar T, Ankanthil R, Vijayan KK, Nair MK. Immunomodulatory effects of a polysaccharide from Tamarindus indica. Anticancer Drugs. 1993;4:209-212. DOI: 10.1097/00001813-199304000-00013.'},{id:"B45",body:'Aravind SR, Joseph MM, Varghese S, Balaram P, Sreelekha TT. Antitumor and immunopotentiating activity of polysaccharide PST001 isolated from the seed kernel of Tamarindus indica: an in vivo study in mice. ScientificWorld Journal. 2012;361382. DOI: 10.1100/2012/361382.'},{id:"B46",body:'Bhadoriya SS, Mishra V, Raut S, Jain S. Antiinflammatory and antinociceptive activities of hydroethanolic extract of Tamarindus indica leaves. Scientia Pharmaceutica. 2012;80:685-700.'},{id:"B47",body:'Suralkar AA, Rodge KN, Kamble RD, Maske KS. Evaluation of anti-inflammatory and analgesic activities of Tamarindus indica seeds. International Journal of Pharmaceutical Sciences and Drug Research. 2012;4:213-217.'},{id:"B48",body:'Escalona-Arranz JC, Péres-Roses R, Urdaneta-Laffita I, Camacho-Pozo MI, Rodríguez-Amado J, Licea-Jiménez I. Antimicrobial activity of extracts from Tamarindus indica L. leaves. Pharmacognosy Magazine. 2010;6:242-247. DOI: 10.4103/0973-1296.66944.'},{id:"B49",body:'Nwodo UU, Obiiyeke GE, Chigor VN, Okoh AI. Assessment of Tamarindus indica extracts for antibacterial activity. International Journal of Molecular Sciences. 2011;12:6385-6396. DOI: 10.3390/ijms12106385.'},{id:"B50",body:'Pratibha G, Gudipati T, Srivasthva A. Antifungal activity and phytochemical analysis of the alcoholic and aqueous extract of the aerial part of the plant Tamarindus indica L. Research Journal of Recent Sciences. 2017;6:8-13.'},{id:"B51",body:'Tayade P, Borde N, Jagtap S, Patil V, Vaishna G, Girbane Y, et al. Effect of Tamarindus indica Linn. against isolated goat tracheal and guinea pig ilium preparation. International Journal Of Comprehensive Pharmacy. 2010;1:1-3.'},{id:"B52",body:'Bin Mohamad MY, Akram HB, Bero DN. Tamarind seed extract enhances epidermal wound healing. International Journal of Biology. 2012;4:81-88. DOI: 10.5539/ijb.v4n1p81.'},{id:"B53",body:'Attah MO, Ishaya HB, Chiroma MS, Amaza DS, Balogun SU, Jacks TW. Effect of Tamarindus indica (Linn) on the rate of wound healing in adult rabbits. IOSR Journal of Dental and Medical Sciences. 2015;14:80-84. DOI: 10.9790/0853-14818084.'},{id:"B54",body:'Naik TI, Shrikanth P, Mundugaru R, Shridhara Bairy ST. Wound healing activity of Tamarindus indica Linn. seed and cork ash. Journal of Ayurveda Medical Sciences. 2017;2:129-135.'},{id:"B55",body:'Bhadoriya SS, Ganeshpurkar A, Narwaria J, Rai G, Jain AP. Tamarindus indica: Extent of explored potential. Pharmacognosy Reviews. 2011;5:73-81. DOI: 10.4103/0973-7847.79102.'},{id:"B56",body:'Kalra P, Sharma S, Suman Kumar S. Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models. Journal of Pharmacy and Bioallied Sciences. 2011;3:236-241. DOI: 10.4103/0975-7406.80778.'},{id:"B57",body:'Izquierdo T, García-Tamayo F, Soto C, Castrillón LE. A Tamarindus indica. Linn pulp polysaccharide inhibits fever in vivo and IL-1β release by murine peritoneal exudate cells. Pharmaceutical Biology. 2007;45:22-30.'},{id:"B58",body:'Mohiuddin AK. Medicinal and therapeutic values of Sesbania grandiflora. Advanced Research Journal of Pharmacy and Pharmacology. 2019;4:87-93.'},{id:"B59",body:'Wagh VD, Wagh KV, Tandale YN, Salve SA. Phytochemical, pharmacological and phytopharmaceutics aspects of Sesbania grandiflora (Hadga): A review. Journal of Pharmacy Research. 2009;2:889-892.'},{id:"B60",body:'Goun E, Cunningham G, Chu D, Nguyen C, Miles D. Antibacterial and antifungal activity of Indonesian ethnomedical plants. Fitoterapia. 2003;76:592-596.'},{id:"B61",body:'Pari L, Uma A. Protective effect of Sesbania grandiflora against erythromycin estolate-induced hepatotoxicity. Therapie. 2003;58:439-443.'},{id:"B62",body:'Ramesh T, Begum VH. Protective effect of Sesbania grandiflora against cigarettes smoke-induced oxidative damage in rats. Journal of Medicinal Food. 2008;11:369-375.'},{id:"B63",body:'Sertié JAA, Wiezel G, Woisky RG, Carvalho JCT. Antiulcer activity of the ethanol extract of Sesbania grandiflora. Brazilian Journal of Pharmaceutical Sciences. 2001;37:107-112.'},{id:"B64",body:'Bhoumik D, Berhe AH, Mallik A. Evaluation of gastric anti-ulcer potency of ethanolic extract of Sesbania grandiflora Linn leaves in experimental animals. American Journal of Phytomedicine and Clinical Therapeutics. 2016;4:174-182.'},{id:"B65",body:'Jalalpurea SS, Alagawadia KR, Mahajanshetty CS. In vitro anthelmintic property of various seed oils. Iranian Journal of Pharmaceutical Sciences. 2006;4:281-284.'},{id:"B66",body:'China R, Mukherjee S, Sen S, Bose S, Datta S, Koley H, et al. Antimicrobial activity of Sesbania grandiflora flower polyphenol extracts on some pathogenic bacteria and growth stimulatory effect on the probiotic organism Lactobacillus acidophilus. Microbiological Research. 2012;167:500-506.'},{id:"B67",body:'Vipin K, Gupta AK, Gupta R. Antimicrobial activity of Sesbania grandiflora (L.) Pers. International Research Journal of Pharmacy. 2011;2:85-87.'},{id:"B68",body:'Anantaworasakul P, Hamamoto H, Sekimizu K, Okonogi S. In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms. Pharmaceutical Biology. 2017;55:1256-1262.'},{id:"B69",body:'Roy A, Bhoumik D, Kumar Sahu R, Dwivedi J. Phytochemical screening and antioxidant activity of Sesbania grandiflora leaves extracts. Asian Journal of Research in Pharmaceutical Sciences. 2014;4:16-21.'},{id:"B70",body:'Karthikeyan P, Suresh V, Suresh A. Wound healing activity of Sesbania grandiflora (L.) Poir. bark. International Journal of Pharmaceutical Research and Development. 2011;3:87-93.'},{id:"B71",body:'Sheikh AA, Sayyed Z, Siddiqui AR, Pratapwar AS, Sheakh SS. Wound healing activity of Sesbania grandiflora Linn flower ethanolic extract using excision and incision wound model in Wistar rats. International Journal of PharmTech Research. 2011;3:895-898.'},{id:"B72",body:'Reyes GL, Wong S, Uera J, Dimagiba MF, Timoteo MAC. Katuray (Sesbania grandiflora) bark extract as oral paint for ulcers. Poster 089. Meeting International Association for Dental Research-South East Asian Division. Bali, Indonesia: 2015.'},{id:"B73",body:'Saifudin A, Forentin AM, Fadhilah A, Tirtodiharjo K, Melani WD, Widyasari D, et al. Bioprospecting for anti-Streptococcus mutans: the activity of 10% Sesbania grandiflora flower extract comparable to erythromycin. Asian Pacific Journal of Tropical Biomedicine. 2016;6:751-754.'},{id:"B74",body:'Uddin MK, Juraimi, Hossain MS, Un Nahar MA, Ali ME, Rahman MM. Purslane weed (Portulaca oleracea): A prospective plant source of nutrition, omega-3 fatty acid, and antioxidant attributes. The Scientific World Journal. 2014;951019. DOI: 10.1155/2014/951019.'},{id:"B75",body:'Dweck AC. Purslane - Portulaca oleracea: the global panacea. [Internet]. 2001. Available from: http://www.dweckdata.com/Published_papers/Portulaca_oleracea.pdf [Accessed: 25-01-2021].'},{id:"B76",body:'Mokhtarifar A, Zeydabadi FA, Asili J, Kooshyar MM, Sahebkar A. The effect of Portulaca oleracea (purslane) seeds on hemoglobin levels in adolescent girls with iron deficiency anemia: A randomized comparative trial. Comparative Clinical Pathology. 2017;26:11-16.'},{id:"B77",body:'Okafor IA, Ezejindu D. Phytochemical studies on Portulaca oleracea (purslane) plant. Global Journal of Biology, Agriculture and Health Sciences. 2014;3:132-136.'},{id:"B78",body:'Zhou Y-X, Xin H-L, Rahman K, Wang S-J, Peng C, Zhang H. Portulaca oleracea L.: A review of phytochemistry and pharmacological effects. BioMed Research International. 2015; 925631. DOI: 10.1155/2015/925631.'},{id:"B79",body:'Oliveira I, Valentão P, Lopes R, Andrade PB, Bento A, Pereira JA. Phytochemical characterization and radical scavenging activity of Portulaca oleraceae L. leaves and stems. Microchemical Journal. 2009;92:129-134.'},{id:"B80",body:'Rafieian-Kopaei M, Alesaeidi S. Portulaca oleraceae: A review study with anti-inflammatory and muscle relaxant perspective. Indian Journal of Medical Research and Pharmaceutical Sciences. 2016;3:50-59.'},{id:"B81",body:'Rashed AN, Afifi FU, Disi AM. Simple evaluation of the wound healing activity of a crude extract of Portulaca oleracea L. (growing in Jordan) in Mus musculus JVI-1. Journal of Ethnopharmacology. 2003;88:131-136. DOI: 10.1016/s0378-8741(03)00194-6.'},{id:"B82",body:'Eldeighdye SM, Abdel-Khalek LG, Taha MS, Allam TM, Hassanian WF, Akaber TK, et al. The therapeutic effect of purslane (Portulaca oleracea) extract on wound healing in diabetic albino rats. World Journal of Pharmacy and Pharmaceutical Sciences. 2016;5:1454-1469.'},{id:"B83",body:'Chan K, Islam MW, Kamil M, Radhakrisha R, Zakaria MN, Habibullah M, Attas A. The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. Sativa (Haw.) Celak. Journal of Ethnopharmacology. 2000;73: 445-451. DOI: 10.1016/s0378-8741(00)00318-4.'},{id:"B84",body:'Fatima N, Syed S, Ahmad M, Mehjabeen, Jahan N. A Comparison of analgesic and anti-inflammatory activities of Portulaca oleraceae leaf and seeds. RADS Journal of Pharmacy and Pharmaceutical Sciences. 2018;6:194-199.'},{id:"B85",body:'Wang H-Z, Wang CJ. Isolation, characterization and analgesic activity of natural allantoin from Portulaca oleracea seed. Modern Chemistry and Applications. 2018;6:1. DOI: 10.4172/2329-6798.1000249.'},{id:"B86",body:'Lee AS, Kim JS, Lee YJ, Kang DG, Lee HS. Anti-TNF-α activity of Portulaca oleraceae L in vascular endothelial cells. International Journal of Molecular Sciences. 2012;13:5628-5644.'},{id:"B87",body:'Kim Y-O, Lee S-W, Na SW, Park HR, ES. Anti-inflammatory effects of Portulaca oleracea L. on the LPS-induced RAW 264.7 cells. Journal of Medicinal Plants Research. 2015;9:407-411. DOI: 10.5897/JMPR2012.1183.'},{id:"B88",body:'Xu L, Ying Z, Wei W, Hao D, Wang H, Zhang W, et al. A novel alkaloid from Portulaca oleracea L. Natural Product Research. 2017;31:902-908.'},{id:"B89",body:'Behravan J, Mosafa F, Soudmand N, Taghiabadi E, Razavi BM, Karimi G. Protective effects of aqueous and ethanolic extracts of Portulaca oleracea L. aerial parts on H2O2-induced DNA damage in lymphocytes by comet assay. Journal of Acupuncture and Meridian Studies. 2011;4:193-197.'},{id:"B90",body:'Karimi G, Aghasizadeh M, Razavi M, Taghiabadi E. Protective effects of aqueous and ethanolic extracts of Nigella sativa L. and Portulaca oleracea L. on free radical induced hemolysis of RBCs. Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2011;19:295-300.'},{id:"B91",body:'Chen B, Zhou H, Zhao W, Zhou W, Yuan Q, Yang G. Effects of aqueous extract of Portulaca oleracea L. on oxidative stress and liver, spleen leptin, PARα and FAS mRNA expression in high-fat diet induced mice. Molecular Biology Reports. 2012;39:7981-7988.'},{id:"B92",body:'Dkhil MA, Moniem AEA, Al-Quraishy S, Saleh RA. Antioxidant effect of purslane (Portulaca oleracea) and its mechanism of action. Journal of Medicinal Plants Research. 2011;5:1589-1593.'},{id:"B93",body:'Kaveh M, Eidi A, Nemati A, Boskabady MH. The extract of Portulaca oleracea and its constituent, alpha linolenic acid affects serum oxidant levels and inflammatory cells in sensitized rats. Iranian Journal of Allergy, Asthma, and Immunology. 2017;16:256-270.'},{id:"B94",body:'Elkhayat ES, Ibrahim SRM, Aziz MA. Portulene, a new diterpene from Portulaca oleracea L. Journal of Asian Natural Products Research. 2008;10:1039-1043.'},{id:"B95",body:'Islam SM, Shawon JAM, Mahmud SAM. Antimicrobial activity of methanol, n-hexane and dichloromethane extract of Portulaca oleracea. Advances in Pharmacology and Clinical Trials. 2018;3:1-4.'},{id:"B96",body:'Oh K-B, Chang I-M, Hwang K-J, Mar W. Detection of antifungal activity in Portulaca oleracea by a single-cell bioassay system. Phytotherapy Research. 2000;14:329-332.'},{id:"B97",body:'Dong CX, Hayashi K, Lee JB, Hayashi T. Characterization of structures and antiviral effects of polysaccharides from Portulaca oleracea L. Chemical and Pharmaceutical Bulletin. 2010;58:507-510. DOI: 10.1248/cpb.58.507.'},{id:"B98",body:'Noreen S, Hussain I, Tariq MI, Ijaz B, Iqbal S, Ul-Zaman Q, et al. Portulaca oleracea L. as a prospective candidate inhibitor of hepatitis C virus NS3 serine protease. Viral Immunology. 2015;28:282-289.'},{id:"B99",body:'Kunnumakkara B, Bordoloi D, Padmavathi G, Monisha J, Roy NK. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. British Journal of Pharmacology. 2017;174:1325-1348.'},{id:"B100",body:'Li S, Yuan W, Deng G, Wang P, Yang P. Chemical composition and product quality control of turmeric (Curcuma longa L.). Pharmaceutical Crops. 2011;2:28-54.'},{id:"B101",body:'Sabale P, Modi A, Sabale V. Curcuma longa Linn. A phytochemical and phytopharmacological review. Research Journal of Pharmacognosy and Phytochemistry. 2013;5:59-68.'},{id:"B102",body:'Rao R, Descamps O, John V, Bredesen DE. Ayurvedic medicinal plants for Alzheimer’s disease: a review. Alzheimer’s Research and Therapy. 2012;4:22. DOI: 10.1186/alzrt125.'},{id:"B103",body:'Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. Journal of Neuroscience. 2001;21:8370-8377.'},{id:"B104",body:'Dairam A, Limson JL, Walkins GM, Antunes E, Daya S. Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats. Journal of Agricultural and Food Chemistry. 2007;55:1039-1044.'},{id:"B105",body:'Zafir A, Banu N. Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats. European Journal of Pharmacology. 2007;572:23-31.'},{id:"B106",body:'Kawasaki K, Muroyama K, Murosaki S. Effect of a water extract of Curcuma longa on emotional states in healthy participants. Bioscience of Microbiota, Food and Health. 2018;37:25-29. DOI: 10.12938/bmfh.17-020.'},{id:"B107",body:'Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. Journal of Psychopharmacology. 2015;29:642-651.'},{id:"B108",body:'Cox KHM, White DJ, Pipingas A, Poorun K, Scholey A. Further evidence of benefits to mood and working memory from lipidated curcumin in healthy older people: A 12-week, double-blind, placebo-controlled, partial replication study. Nutrients. 2020;4:1678. DOI: 10.3390/nu12061678.'},{id:"B109",body:'Fusar-Poli L, Vozza L, Gabbiadini A, Vanella A, Concas I, Tinacci S, et al. Curcumin for depression: A meta-analysis. Critical Reviews in Food Science and Nutrition. 2020;60:2643-2653.'},{id:"B110",body:'Thong-Ngam D, Choochuai S, Patumraj S, Chayanupatkul M, Klaikeaw N. Curcumin prevents indomethacin-induced gastropathy in rats. World Journal of Gastroenterology. 2012;18:1479-1484.'},{id:"B111",body:'Ukil A, Maity S, Karmakar S, Datta N, Vedasiromoni JR, Das PK. Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. British Journal of Pharmacology. 2003;139:209-218.'},{id:"B112",body:'Prucksunand C, Indrasukhsri B, Leethochawalit M, Hungspreugs K. Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn) on healing of peptic ulcer. Southeast Asian Journal of Tropical Medicine and Public Health. 2011;32:208-215.'},{id:"B113",body:'Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clinical Gastroenterology and Hepatology. 2006;4:1502-1506.'},{id:"B114",body:'Kumar S, Ahuja V, Sankar MJ, Kumar A, Moss AC. Curcumin for maintenance of remission in ulcerative colitis. Cochrane Database of Systemic Reviews. 2012;17:CD008424.'},{id:"B115",body:'Rahman SF, Hardi GW, Maras MAJ, Riva YR. Influence of curcumin and ginger in primary dysmenorrhea: A review. International Journal of Applied Engineering Research. 2020;15:634-638.'},{id:"B116",body:'Kim SO, Kundu JK, Shin YK, Park J-H, Cho M-H, Kim T-Y, et al. 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Antigenotoxic effect of genistein and gingerol on genotoxicity induced by norethandrolone and oxandrolone in cultured human lymphocytes. International Journal of Pharmacology. 2008;4:177-183.'},{id:"B138",body:'Vinothkumar R, Sudha M, Nalini N. Chemopreventive effect of zingerone against colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. European Journal of Cancer Prevention. 2014;23:361-371.'},{id:"B139",body:'Teles AM, dos Santos BA, Ferreira CG, Mouchreck AN, da Silva Calabrese K, Abreu-Silva AL, Almeida-Souza F. (December 6th 2019). Ginger (Zingiber officinale) antimicrobial potential: A review. In: Ginger cultivation and its antimicrobial and pharmacological potentials, Haiping Wang, IntechOpen. DOI: 10.5772/intechopen.89780.'},{id:"B140",body:'Okiki AP, Oyetunji O, Benjamin O. Antibacterial activity of ginger (Zingiber officinale) against isolated bacteria from the respiratory tract infections. Journal of Biology, Agriculture and Healthcare. 2015;5:131-138.'},{id:"B141",body:'Nagoshi C, Shiota S, Kuroda T, Hatano T, Yoshida T, Kariyama R, et al. Synergistic effect of [10]-gingerol and aminoglycosides against vancomycin-resistant enterococci (VRE). Biological and Pharmaceutical Bulletin. 2006;29:443-447. DOI: 10.1248/bpb.29.443.'},{id:"B142",body:'Imanishi N, Andoh T, Mantani N, Sakai S, Terasawa K, Shimada Y, et al. Macrophage mediated inhibitory effect of Zingiber officinale Rosc, a traditional oriental herbal medicine, on the growth of influenza A/Aichi/2/68 virus. The American Journal of Chinese Medicine. 2006;34:157-169. DOI: 10.1142/S0192415X06003722.'},{id:"B143",body:'Chang JS, Wang KC, Yeh CF, Shieh DE, Chiang LC. Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. Journal of Ethnopharmacology. 2013;145:146-151.'},{id:"B144",body:'Sahoo M, Jena L, Rath SN, Kumar S. Identification of suitable inhibitor against influenza A (H1N1) neuraminidase protein by molecular docking. Genomics and Informatics. 2016;14:96-103.'},{id:"B145",body:'Mahady GB, Pendlan SL, Yun GS, Lu Z-Z, Stoia A. Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori. Anticancer Research. 2003;23:3699-3702.'},{id:"B146",body:'Ebrahimzadeh Attari V, Somi MH, Asghari Jafarabadi M, Ostadrahimi A, Moaddab SY, Lotfi N. The gastro-protective effect of ginger (Zingiber officinale Roscoe) in Helicobacter pylori positive functional dyspepsia. Advanced Pharmaceutical Bulletin. 2019;9:321-324. DOI: 10.15171/apb.2019.038.'},{id:"B147",body:'Zehsaz F, Farhangi N, Mirheidari L. The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners. Central European Journal of Immunology. 2014;39:174-180.'},{id:"B148",body:'Ezzat SM, Ezzat MI, Okba MM, Menze ET, Abdel-Naim AB. The hidden mechanism beyond ginger (Zingiber officinale Rosc.) potent in vivo and in vitro anti-inflammatory activity. Journal of Ethnopharmacology. 2018;214:113-123'},{id:"B149",body:'Tjendraputra E, Tran VH, Liu-Brennan D, Roufogalis BD, Duke CC. Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorganic Chemistry. 2001;29:156-163.'},{id:"B150",body:'Lin R-J, Chen C-Y, Chung L-Y, Yen C-M. Larvicidal activities of ginger (Zingiber officinale) against Angiostrongylus cantonensis. Acta Tropica. 2010;115:69-76. DOI: 10.1016/j.actatropica.2009.12.007.'},{id:"B151",body:'Lin RJ, Chen C-Y, Lee J-D, Lu C-M, Chung L-Y. Larvicidal constituents of Zingiber officinale (ginger) against Anisakis simplex. Planta Medica. 2010;76:1852-1858.'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Dennis R.A. 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Department of Pharmacology, Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, Suriname
Department of Pharmacology, Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, Suriname
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The Oryza sativa species, which is grown worldwide, is far more widely utilized compared with the Oryza glaberrima species, which is grown in West Africa. Recently, the annual rice production has reached almost 480 million tonnes, and this demand is expected to rise to 550 million tonnes in 2035. Thus, this increases the need to characterize and maintain the quality of rice and hence to determine the price of rice appropriately. Obviously, modern technologies that can provide fast and accurate measurement are essential in the large-scale industrial rice processing. In this chapter, several technologies and instruments used for rice processing are reviewed. The principle of the measurement for each technology is briefly described. The strength of this chapter is to introduce the application of microwave technology during rice processing, such as rice dying process, rice moisture detection, broken rice measurement and rice insect control. 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He pursued his MSc degree in Microwave from the Faculty of Science in 2003 and his PhD degree in Wave Propagation from the Institute for Mathematical Research, Universiti Putra Malaysia (UPM), Serdang, Selangor, Malaysia in 2006. His main personal research interest includes the theory, simulation, and instrumentation of electromagnetic wave propagation at microwave frequencies focusing on the development of microwave passive devices and sensors for medical and agricultural applications. 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UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
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Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:228,paginationItems:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",biography:"Dr. Aneesa Moolla has extensive experience in the diverse fields of health care having previously worked in dental private practice, at the Red Cross Flying Doctors association, and in healthcare corporate settings. She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/194722",hash:"",query:{},params:{id:"194722"},fullPath:"/profiles/194722",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()