Imaging technique findings in the right-sided infective endocarditis.
\r\n\t2) Human sexual disorders in males and females.
\r\n\t3) Psychological aspects of the human sexual response cycle and its disorders.
\r\n\t4) The therapeutic aspects.
\r\n\tThe human sexual response cycle and human sexual behavior are interrelated. How this inter-relationship and its association to normal sexual health need to be delineated. In a world torn between sex and sexually transmitted disease, clear-cut scientific information in the form of a monograph is required to educate.
\r\n\r\n\tHuman sexuality, gender identity, and sexuo-erotic orientation play great roles in human health and disease. Sex education is the need of the hour and a reflection will be timely.
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It is seen most frequently in people with intravenous drug addiction; nevertheless, other portions of the population are in high risk of developing this disease such as patients with indwelling catheters, cardiac devices, congenital cardiac pathologies, and immunocompromised diseases [1, 2, 3].
The evolution of right-heart IE is much better than the left-side IE with a lower rate of mortality (3–30%) [3]. This pathology is more frequent in people between 20 and 61 years, with a mean age of 38 ± 15 years [4].
Common symptoms secondary to right-sided endocarditis are the respiratory symptoms characterized by a cough, hemoptysis, persistent fever, dyspnea, and chest pain [4].
In exceptional circumstances, right-heart failure can arise, generated by the increase in pulmonary pressure, severe tricuspid valve regurgitation, or obstruction of pulmonary circulation through multiple pulmonary emboli [4, 6].
The diagnosis of RSIE is often delayed because the signs and symptoms are relatively different concerning the LSIE clinical setting; the Duke’s modified criteria do not have value in the RSIE. The low incidence of RSIE also plays an essential factor in the underdiagnosis of this disease.
There are reports in which the 76% of the patients had gotten an antibacterial treatment before the endocarditis’s diagnosis because they developed some signs and symptoms that were misunderstood as a febrile syndrome or pneumonia [4].
An acute beginning of the disease is seen at the majority of the patients; only a few cases have been reported with chronic symptoms (more of 2 months) [4].
It is frequent that right-side vegetations dislodge microemboli to the pulmonary region. The pulmonary embolism (PE) can induce pulmonary infarction, abscesses, pneumothoraxes, and purulent pulmonary effusions.
Persistent fever associated with pulmonary events, anemia, and microscopic hematuria, the so-called “tricuspid syndrome,” is the sign of clinical alert for tricuspid valve IE [3, 4, 7].
Revilla et al. found 24% of their patients with this syndrome, and the other 65% had at least two of the three signs [4].
Nowadays it is routinary to order blood tests for any patient admitted at the hospital, and it is reasonably used if the suspicion of infection is thought. Some findings such as high titers of white blood cells, procalcitonin, and C-reactive protein can support the infection diagnosis; nevertheless, these variables are not used as criteria to diagnose infective endocarditis [5, 8].
The anemia has been described as part of the tricuspid syndrome, so the values of hemoglobin and hematocrit below the normal range can be found in the blood test, which probably will reveal a normocytic, normochromic anemia patron [3, 4, 7].
The urine test can show microhematuria which also is part of the tricuspid syndrome.
Right-sided endocarditis in IVDA is commonly caused by
In the majority of patients, the microorganism can be identified through blood cultures if they are adequately collected. The 2015 ESC endocarditis guidelines recommend a technique of recollection minutely sterile of at least three sets of samples with an interval of 30 minutes; each sample must contain 10 ml of blood and should be incubated in both aerobic and anaerobic atmospheres. Another crucial aspect is the recollection of samples from a peripheral vein instead of central venous catheter due to the risk of contamination and wrong interpretation [5].
Occasionally, the blood cultures can be negative by different reasons, especially if an antimicrobial therapy was established before the acquisition of the samples. The blood cultures usually become negatives after 48 hours from the beginning of antibiotics [4].
Currently, the diagnosis of IE requires the finding of an infective process inside the heart, reason why the imaging techniques are valuable to diagnose or discard IE. The echocardiography is the most important and more used tool to diagnose, manage, and monitor patients with IE [5].
However, other imaging methods have been developed in the last decades, allowing us to back the diagnosis of IE when the echography is not entirely clear in some cases (Table 1).
Imaging technique findings in the right-sided infective endocarditis.
It can be quite normal or shows a variety of findings, such as cardiomegaly, pulmonary septic emboli, or pleural effusion [4].
The benefits that the echocardiography brought to the cardiology area are well-known, and they can help us to detect anomalies related to IE. It is the gold standard imaging test for IE, becoming one of the first steps that we must do if IE is suspected [3, 9].
The same as the LSIE, the transthoracic echocardiography (TTE) is the first modality recommended to perform if RSIE is suspected. The sensitivity of TTE to detect vegetations is roughly 75% and its specificity over 90%. When the hunch of IE is high, but the TTE is negative, the transesophageal echocardiography (TOE) must be used because its sensitivity is higher than TTE, approximately 96%. Some experts indeed recommend TOE even if the TTE is positive for IE; nevertheless, it does not apply for RSIE in which an explicit finding of IE is enough for the diagnosis [5, 9].
The 2015 ESC guidelines also suggest the use of TOE when the suspicion of IE is present in patients with a prosthetic heart valve and intracardiac device [5].
There are some “typical lesions” of IE that we can detect in the echocardiography, such as vegetations, abscess, pseudoaneurysm, valve aneurysm, perforation, fistula, and dehiscence of the prosthetic valve, being the vegetation of the landmark lesion of this disease (Figure 1) [5, 9].
Transesophageal echocardiogram: a hyperechoic lesion (red arrow) is seen at level of pulmonary valve, prolapsing to right ventricle outflow tract.
Occasionally, parts of the vegetations can be visualized floating in the right ventricle or entrapped in the subvalvular apparatus. TTE usually allows assessment of tricuspid valve involvement because of the valve’s anterior location and large natural vegetations. TOE imaging is more sensitive to detect vegetations than TTE imaging, especially in the case of abscesses, and associated left-sided involvement [6].
Cardiac computed tomography (CCT) can improve the diagnosis of IE when abscesses and pseudoaneurysm are present, due to its higher sensitivity (approximately 81%) in comparison with TTE and TOE (roughly 63%). The combination of echocardiography and CCT to diagnose abscess/pseudoaneurysm reaches 100% sensitivity. In pulmonary/right-sided endocarditis, CT may reveal concomitant pulmonary disease, including abscesses and infarcts [5, 10].
The use of MR in the IE setting is focused on the diagnosis of cerebrovascular events related to IE. This imaging modality has better sensitivity than CT to detect brain hemorrhage and infectious intracranial aneurysms (IIAs) [5, 11].
The incorporation of positron-emission tomography (PET) in the modified Duke’s criteria is addressed to enhance the IE diagnosis in some situations where the clinical suspicion is not always confirmed with the echocardiography. This imaging technique is especially valuable in the diagnosis of prosthetic valve infective endocarditis (PVIE) [5, 12].
There are also reports where the PET helped to determine the extension of pacemaker or defibrillator infection, consequently improving the adequate surgical intervention [13].
Peripheral embolic and metastatic infectious events can also be detected with this technique; nevertheless, their specificity is lower in brain septic emboli [5].
A correct interpretation of PET must be taken in some conditions which can make us misinterpret the findings, for instance, a recent cardiac surgery usually shows enhancement at the mediastinal area due to the inflammatory response. Some conditions can show similar patterns to that of IE, such as an active thrombus, soft atherosclerotic plaques, vasculitis, primary cardiac tumors, cardiac metastasis from a non-cardiac tumor, postsurgical inflammation, and foreign body reactions [5].
The same fundamental aspects about the antibiotic therapy in IE is applied to the right-sided endocarditis, making emphasis in the early and proper setting of the cultures, the prompt and adequate starting of empirical antimicrobial therapy (if the suspicious of IE is higher), and the administration of a culture-antibiogram sensible antibiotic.
One aspect that changed in the antimicrobial treatment of RSIE in comparison with LSIE is the duration of the therapy when the implicated bacteria is the methicillin-sensible
The prophylactic treatment in the patient with high suspicion of RSIE should cover
In RSIE, the medical treatment usually resolves the disease; nevertheless, the surgery for right-sided infective endocarditis is recommended in the following situations: (1) right-heart failure due to severe tricuspid valve regurgitation, (2) inability to eliminate bacteremia or organisms resistant to culture-directed antibiotic treatment, within 7 days, and (3) tricuspid valve vegetations >20 mm [1, 2, 3, 5].
During the surgery, most of the infected tissue must be removed; if it is possible, we should try to repair the native valve but guarantee the adequate functioning of the valve. When a valve-sparing is impossible, the implantation of a prosthetic valve is necessary, always trying to use the less foreign material to diminish the risk of IE recurrence [14].
Sometimes the endocardial destruction is highly extensive that compromises the valve repairing as well as the valve prosthesis replacement; this scenario is hideous and requires the reconstruction of the annular structure using endocardium patch or other materials.
Another potential complication of IE can be the formation of ventricular septal defect due to the infection’s aggressiveness which can show communication between the right ventricle and left ventricle through the membranous septum. This anatomical defect also can be figured out with a pericardium patch [15].
Some surgeons can feel uncomfortable with the idea of setting up a prosthetic valve in tricuspid position due to being afraid of high gradients through the valve and the potential thrombosis of the prosthesis. However, large prostheses (>30 mm) guarantee low transvalvular gradients, and the incidence of thrombosis is small if the patient has an adequate anticoagulation control (biological and mechanic prostheses are anticoagulated). Moreover, bioprosthesis degeneration develops more slowly owing to the low-pressure conditions in the right ventricle [6].
In 1991, Arbulu et al. published a paper showing their experience in tricuspid valvulectomy without replacement, generally indicated for IVDA, to avoid the potential IE recurrence; nevertheless, about 25% of patients cannot tolerate tricuspid regurgitation and require a second operation for tricuspid valve replacement [14, 16].
RSIE implies a better prognosis than LSIE; the previous study revealed the mortality of right-sided IE is 12% in-hospital patients and 0–7.3% for surgical patients. However, these percentages increase at least twice in patients with intensive care unit (ICU) admission; actually, this issue will be described forward [3, 9].
Concomitant left-sided IE carries a worse prognosis than right-sided infection alone, due predominantly to its greater likelihood for invasion and abscess formation [7].
The high increase of bacterial resistance throughout the last decades has produced a change in the IE guidelines from 2002. The same criteria for LSIE are applied to RSIE regarding the antimicrobial prophylaxis, being reserved only in patients with a high risk of endocarditis, particularly those with PVIE [5].
Nevertheless, there are some aspects that the last IE guidelines do not approach which are very relevant that need to be highlighted. One of the most critical issues is the quite strict aseptic measurements that healthcare professionals must take during routine procedures, especially invasive maneuvers in high-risk patients such as immunocompromised, hemodialytic (HD), cyanotic congenital heart disease (CHD) patients, etc.
The change in some hospital policies can diminish the incidence of bacteremia and IE, such as have been shown in some publications [17].
There are few publications about the characteristics of RSIE in ICU. It is noteworthy that patients with IE admitted in ICU have a higher rate of morbidity and mortality than non-ICU patients. The only study describing the outcome of IDUs with RSIE needing ICU admission reported a mortality of 26% [2].
Some factors have been associated with a worse prognosis: acute respiratory failure requiring mechanical ventilation, shock, Simplified Acute Physiology Score (SAPS II) ≥ 20, and Sequential Organ Failure Assessment (SOFA) ≥ 3 [2, 5].
Other elements that play an essential role at the 30-day survival are age <45 years, Charlson score < 3, endocarditis diagnosed before ICU admission, aminoglycoside use, the presence of septic pulmonary embolism, and a single surgical indication for patients needing a surgical procedure [2].
Reasons for admission to the ICU were a congestive cardiac failure (64%), septic shock (21%), neurological deterioration (15%), and cardiopulmonary resuscitation (9%). Younger patients have a better prognosis because they usually present a minimal dysfunction of the right-sided valve, low risk of pulmonary embolism, and reasonable response to appropriate antibiotic therapy [2].
Opposite to the last IE guidelines, which no longer recommend the aminoglycosides in the treatment of native valve staphylococcal endocarditis, Georges et al. found a better survival in their patients treated with a combination of penicillins or vancomycin with gentamicin [2].
It is imperative to describe this pathology in the people with susceptible risk factors (Table 2).
Characteristics of principal risk factors in the right-sided infective endocarditis.
AVF: arteriovenous fistula, HD: hemodialytic, HIV: human immunodeficiency virus, IE: infective endocarditis, RSIE: right-sided infected endocarditis, VSD: ventricular septal defect.
The majority of cases of RSIE reports in the literature are in drug abusers. This kind of populations of RSIE represents the 32–86% of all IE [2, 3].
There are multiple explanations about the preference of infection in the right side of the heart at this group of the population, being the leading causes of the poor hygiene with unsafe injection practices and the affected immunology well-being. The higher bacterial load and the variety of effects of injected substances over the endocardium also play an essential role in the physiopathology of the infection [7].
The incidence of reinfections and reoperations is about 28 and 20%, respectively; however, the survival described in some papers is almost equal between drug abusers and not drug abusers, in which results are very striking [7].
Sometimes IVDA also presents human immunodeficiency virus (HIV) which can aggravate the predisposition to IE if this disease is not well-controlled. The death rates in this subgroup of patients are about 5–10% [1]. The HIV affects both humoral and cellular immunities which provoked a predisposition for recurrent episodes of bacteremia that cause valve damage, fibrin deposition, thrombus formation, and adherence by bacteria in the endocardium; it is common to find abscess developments and large vegetations, which are indications for early surgical treatment [18].
The choice of empiric antimicrobial therapy depends on the suspected microorganism and type of drug and solvent used by the addict and the location of infection.
As previously was described, the empirical antimicrobial therapy must cover
The 2015 ESC IE guidelines recommend an antipseudomonal therapy in patients with pentazocine addiction if IE is suspected; nevertheless, there are few and relatively old studies about this issue [5, 19, 20].
If an IVDA uses brown heroin dissolved in lemon juice,
Although the majority of IE at the right side of the heart is fairly reported in IVDA, there is an increasing incidence in another type of patients, mainly highlighting the people with indwelling catheters and cardiac devices. The 5–10% of RSIE occur in nonaddicted patients [3].
It is estimated that more than 3 million people worldwide require dialysis for end-stage renal disease, and this number is expected to rise sharply because of the aging of the population and an increasing prevalence of diabetes and cardiovascular comorbidities paralleled by a decline in cardiovascular mortality, particularly in very elderly patients (>80 years). For instance, in the United States, this augmentation is about 3.2% per year [21, 22].
Hemodialysis patients are at increased risk for bacteremia, including an estimated 37,000 central line-associated bloodstream infections related to outpatient hemodialysis in the United States in 2008. The elevated incidence of bacteremia increases the risk for infective endocarditis [22, 23].
The average duration on HD before the diagnosis of IE was 30 months (range, 4–66 months). IE is one of the most important causes of increased mortality and morbidity among hemodialysis patients [24].
The
IE occurs 18 times more frequently in chronic HD patients than in the general population [25, 26].
The use of temporal or permanent central catheters, the constant puncture of arteriovenous fistulas, the long and frequent hospitalizations that some of these patients have to suffer during their disease, the various surgical procedures related with the creation of fistulas, and the underlying alteration of their defenses become susceptible to this population to develop IE.
The IE in HD patients is calculated about at 8% of all observed IE cases regarding the largest international cohort collected to date [27].
The incidence of IE usually increases with the time after the initiation of hemodialysis; however, some studies found a rise of this incidence in the first 5 months after the initiation of hemodialysis [26, 28]. This contradictory results can be probably due to the aseptic technique during the manipulation of the catheter and arteriovenous fistulas of these patients.
Patients in HD also present an increase in the incidence of endocarditis after aortic valve replacement surgery, affecting at the same time the short-term and long-term survival [22].
Most of the studies show that central catheters are a risk factor for bacteremia and endocarditis [6, 7, 10]; nevertheless, Farrington et al. did not find an increase of endocarditis in patients with central catheters in comparison with patients with arteriovenous fistulas [22].
Besides, the rates of IE are more significant in patients with non-cuffed catheters than cuffed catheters; the vascular grafts have more incidence of IE than AV fistulas. Furthermore, peritoneal dialysis has then lesser rates of IE due to the lack of contact of the line with luminal vessels [29].
The morbidity and mortality are higher than the general population; in the 20% of hemodialysis-related IE, the tricuspid valve is the principal place affected at the right side of the heart.
The pathogenesis of IE in HD patient can be attributed to recurrent episodes of bacteremia, the immunological compromise of hemodialytic patients and heart valvular deterioration-calcification frequently founded in this patients.
It can sound logical that the majority of cases of IE in HD patients should happen on the right cavities, similar to what occurs in IVDA; however, the left-side heart (90%) is the more frequent infected place in HD patients, the mitral being the main valve affected. The affectation of the right cavities is roughly 10%. Nevertheless, some papers report an incidence of RSIE in HD patients of between 0 and 50% [30, 31].
Between the multiple explanations of pathogenesis RSIE in HD patients, the high turbulent flow throughout the valves can provoke a deterioration at these structures, becoming more susceptible to bacterial implantation. Nonetheless, the low pressures at the right cavities might not present the same effect in their valves. One possible cause can be the associated pulmonary hypertension that some patients express, due to multiple factors, such as an increased cardiac output (hypervolemic condition and arteriovenous fistula), an increased pulmonary vascular resistance (uremic endothelial dysfunction and pulmonary artery calcifications), and elevated pulmonary capillary wedge pressure caused by heart failure or mitral valve disease [17].
Patients in HD have an increased risk of developing IE due to all the reasons described before, so to take some measurements sounds logical to diminish the incidence of bacteremia which can result in an IE.
In some hospitals, their politics have been changed regarding the hemodialysis procedure with the intention to ameliorate the arteriovenous life expectancy and decrease the local and systemic infections. For instance, Oun HA et al. have published a lowering in the bacteremia and IE at his hospital adopting new strategies, such as changing the lock solution to taurolidine, cleaning the puncture site with chlorhexidine 2%, and using the buttonhole technique instead of the rope ladder technique. Nonetheless, it is important to mention that the buttonhole technique had a modest but not significative rising of bacteremia following the move to buttonhole [26].
The arteriovenous fistula (AVF) must always be the best option to perform HD due to their low rates of bacteremia and IE, so, it is imperative to develop an adequate surgical technique and improve the care of the fistula. Whenever it is possible, the fistula must be carried out at the distal part of the arms, trying to preserve the proximal areas to future AVF if the distal fistula fails at some point. If the HD needs a temporary or permanent catheter, the cuffed ones always are preferable to non-cuffed catheters, because the former cause fewer rates of IE [29].
The patient and healthcare personnel must be informed and trained regarding the proper care of the AVF and catheters to lower the probability of bacteremia and IE. The cleaning of the surgical area is paramount as well as the correct AVF puncture.
Nowadays ICD are widely used worldwide; their implementation in the cardiology area has improved the quality of life of many people and increased the survival; nonetheless, they have side defects, the endocarditis being one of the most severe complications.
The IE on a cardiac device is increased in the last 10 years in the first-world countries, even becoming the most common cause of IE in some regions. This phenomenon is caused mainly by the rise in the longevity in these countries which results in a growing number of intracardiac devices implanted (pacemakers, cardiac defibrillator, cardiac resynchronizer, or ventricle assist device) [32].
This IE is associated with a worse prognosis and high mortality (11–36%) [32, 33, 34]. The pacemaker generator or lead change is the higher factor of risk for IE on the cardiac device. The tricuspid valve is the most common site of RSIE associated with this kind of devices [7, 35].
The removal of the infected device is mandatory in the treatment of intracardiac device infective endocarditis (ICDIE) because it decreases the hospital mortality [32]. Patients with device-related infection and intracardiac vegetations higher or equal at 1 cm have historically undergone surgery for device removal due to the potential risk for septic embolization [34].
The risk of IE in patients with adult congenital heart disease (ACHD) is substantially higher (15–140 times) than in the general population. The RSIE in CHD is more often in adults than pediatric patients [5, 36].
The ventricular septal defect (VSD) is the most frequent anomaly in right-sided IE with an incidence of 0.2–2% of all IE [37].
The risk of IE can occur either in repaired or not repaired VSD, with a higher increase in the last one [38].
A recent paper from Tutarel et al. found an incidence of 15.9% of IE in patients with VSD; the 50% of these cases were associated with infections of either the tricuspid valve or the right ventricular outflow tract [36].
The 2015 ESC IE guidelines describe that the distribution of causative organisms does not differ from the pattern found in acquired heart disease, with streptococci and staphylococci being the most common strains. Another study found the streptococci responsible for 50% of congenital heart disease infective endocarditis (CHDIE) and the staphylococci with a 31% incidence [5, 36].
The pulmonary valve is affected in almost 32% of patients from which over an 84% are prosthetic and near 16% native valve [36].
Unlike the left-sided IE mainly occurring on the aorta or mitral valve, right-sided IE could involve the tricuspid valve (82%), pulmonary valve, eustachian valve, interventricular septum, right ventricular free wall, or CS [4, 9].
The vast majority of RSIE cases involve the TV (approximately 90%). The high risk of vegetations on the TV is septic PE resulting in various pulmonary complications such as pneumonia and pulmonary abscess.
Uncomplicated tricuspid valve endocarditis can be successfully treated medically in 80% of patients and in the remaining 20% with very large vegetations and expectably poor antibiotic penetration [6].
The infection of the native tricuspid valve in nonaddicted adults occurs in younger patients (under 50 years). In the majority of cases (70%), there are underlying medical conditions such as alcoholism, abortion, colon disease, immunodeficiency, permanent catheters, septic processes in the oral cavity, skin, or genitals, etc. The 25% of cases require valve replacement or surgery [3] (Figure 2).
Pulmonary native endocarditis: a giant mass anchored to the posterior leaflet of pulmonary valve [
RSIE in PV happens in less than 10% of the patients [7]. Most of the cases of pulmonary valve infective endocarditis (PVIE) are provoked by prosthetic material present at this place due to previous surgeries or interventional procedures focused on figuring a congenital disease out.
Bovine jugular grafts are associated with a significantly higher risk of late endocarditis compared with homografts [39].
However, Robichaud et al. did not find an increased risk of PVIE regarding the type of valve, including bovine jugular vein grafts [40].
The rate of IE in transcatheter pulmonary valve implantation is higher than surgical homograft implantation [41].
Uniquely few case reports have been published about RSIE in other locations different to tricuspid and pulmonary valves.
Reports of eustachian valve infective endocarditis (EVIE) are approximately 29 cases [43]. An incidence of 3.3% in patients with right-sided endocarditis has been reported [44].
Eustachian valve is a rudimentary structure in adults and, during fetal life, directs oxygenated blood from the inferior vena cava through the foramen ovale and into the left atrium [43, 45].
IVDA is the main high-risk population to develop an EVIE (over 50% of cases).
There are only eight reported cases of IE in the coronary sinus (CS). The clinical manifestations, the complementary test, the responsible bacteria, and antibiotic treatment are very similar to the other RSIE locations. The CSIE has some features; the CS is always dilated and generally the only affected valve; the vegetation is usually mobile and has a tubule shape with a length of >10 mm [9, 46].
RSIE is a pathology scarcely studied because there are few articles released about it. One of the significant reasons about the RSIE little information is the low incidence of this disease; nevertheless, the rates of frequency of this infection are rising nowadays due to the steady increase of HD patients and implanted ICD.
RSIE clinic criteria are necessary to establish to help in the diagnosis of the disease, such as modified Duke criteria.
Healthcare personnel must be aware of this illness, keeping their suspicion in high-risk patients and performing the proper complementary test to confirm or discard this infection.
Hospital policies should be continuously updated to diminish the incidence of RSIE, an adequate epidemiologic analysis about RSIE cases, the population in potential risk to acquire the infection, and the most frequent bugs implicated in this one.
None.
ACHD | adult congenital heart disease |
AVF | arteriovenous fistula |
CHD | congenital heart disease |
CHDIE | congenital heart disease infective endocarditis |
CS | coronary sinus |
CT | computed tomography |
EVIE | eustachian valve infective endocarditis |
HD | hemodialytic |
HIV | human immunodeficiency virus |
ICD | intracardiac devices |
ICU | intensive care unit |
IE | infective endocarditis |
IIAs | infectious intracranial aneurysms |
IVDA | intravenous drugs addiction |
LSIE | left-side infective endocarditis |
MRSA | methicillin-resistant Staphylococcus aureus |
MR | magnetic resonance |
PET | positron-emission tomography |
PE | pulmonary embolism |
PVIE | prosthetic valve infective endocarditis |
PV | pulmonary valve |
RSIE | right-side infective endocarditis |
SAPS | Simplified Acute Physiology Score |
SOFA | sequential organ failure assessment |
TTE | transthoracic echocardiography |
TOE | transesophageal echocardiography |
TV | tricuspid valve |
VSD | ventricle septal defect |
Carbon dioxide (CO2) is a naturally arising gas by the method of photosynthesis into organic matter. A derivative of fossil fuel ignition and biomass burning, it is also released from the changes in the use of lands and other industrial activities. Earth’s radiative stability is continuously disturbed primarily by carbon di oxide. CO2 is considered to be a reference gas for the measurement of other greenhouse gases and thus having a Global Warming Potential of 1. The rate of global warming increase is because of the climate change and escalation in the concentrations of atmospheric carbon dioxide.
This is because of the increase in the custom of using carbon based fuels especially in the present modern world. CO2 is also a key cause of marine acidification as it softens in water to produce carbonic acid. The earth’s radiative balance gets disturbed because of the continuous addition of greenhouse gases in the atmosphere. As a result, we observe an increase in the earth’s surface temperature and extreme changes in climate, rise in sea levels, and harmful effects on world agriculture. Since the past two decades, global emissions of carbon dioxide have risen by 99%, or on an average 2.0% for a year, and it is expected to rise by another 45% by the end of 2030, or increase in the rate of 1.6% per year.
The emergence of chloro flouro carbons which are popularly known as CFC has not happened in a day. Natural refrigerants like water, carbon di oxide were used in refrigeration and air conditioning industry in the past which did not impose any destructive effects to the environment and ozone layer. Later on, chloro flouro carbons were introduced by the company Dupon in the year 1930, as a result of remarkable developments in the refrigeration industry. CFC’s were released to the atmosphere carelessly during service and repairing of refrigeration and air conditioning equipment. Then it reaches the topmost layer of the atmosphere and destroys the ozone layer, which leads to many harmful effects to humans, animals and crop cultivation. Below Table 1 shows the brief history and the evolution of chloro flouro carbons.
Sl.No | Year | Refrigerant | Comment |
---|---|---|---|
1 | 1930 | — | Announcement of the development of Fluorocarbon refrigerant |
2 | 1931 | R-12 | Commercial refrigerant |
3 | 1932 | R-11 | Commercial refrigerant |
4 | 1933 | R-114 | Commercial refrigerant |
5 | 1934 | R-113 | Commercial refrigerant |
6 | 1936 | R-22 | Commercial refrigerant |
7 | 1943 | R-11 & R-12 | Developed to use as an aerosol propellants |
8 | 1945 | R-13 | Introduced as a commercial refrigerant |
9 | 1949 | R-500 | Patented by carrier corporation |
10 | 1952 | — | Manufacture of fluorocarbon refrigerants |
11 | 1955 | R-14 | Introduced as a commercial refrigerant |
12 | 1957- 1963 | — | Production of fluorocarbon refrigerants started by other industries |
13 | 1961 | R-502 | Introduction of R-502 in a commercial manner |
14 | 1975 | R-12 & R-13 | Thermodynamic properties were established |
History and evolution of chloro flouro carbons.
In early 1970s, scientists come to know about the hazardous impacts contributed to the earth’s atmosphere by Chlorofluorocarbons (CFCs). CFCs were widely used as foams, refrigerants and thinners for many industrial applications. UV-B radiation which is passing through the ozone depletion areas from the sun can spread straight to the Earth’s surface and will cause distinctive harms in the human cells, plants and animals. And this is because of the ozone layer destruction by CFC’s. An international treaty was decided at Montreal, Canada, to ensure further damage of ozone layer. The outcome of Montreal protocol was to begin the phasing-out the usage of CFCs and other Ozone Depleting Substances (ODS) like Hydro chloro fluorocarbons (HCFCs).
Hydro fluoro carbons (HFCs) are considered to be one of the major, fastest growing, and most potent, greenhouse gases. In the past two decades, discharges of hydro fluoro carbons (HFCs) have been increasing swiftly. HFC’s are the substitutes for chlorofluorocarbons and hydro chloro fluoro carbons (HCFCs). But stratospheric ozone is not destroyed by HFC’s, but they are considered to be one of the effective greenhouse gases with a significant global warming potential (GWP) [1]. Many commercial refrigeration systems, such as beverage coolers, vending machines, ice cream freezers, open deck coolers and freezers used in hypermarkets use Hydro chloro fluorocarbons (HCFCs) and Hydro fluoro carbons (HFCs) gases as refrigerants. HCFCs are one of the ozone depleting agents and they have to be phased out as per the Montreal Protocol.
Even though the phasing out of CFC’s are a great success in developed countries, there is still a delay in phasing out of HCFC’s in the developing countries. There is a need of awareness among the general public about the safe use of fluorinated refrigerants and their adverse effects to our planet earth. Necessary training for the refrigeration and air conditioning technicians in the developing countries as this will ensure the safe recovery of these harmful refrigerants. There is a repeated history prevailing now in the use of natural refrigerants in the air conditioning industry. Because of the climatic changes and associated global warming problems, nowadays natural refrigerants are preferred in place of CFC’s. In the present technology in the refrigerant sector, two ozone-friendly refrigerant technologies are available instead of CFC’s: 1. Fluorinated refrigerants (HFC’s) which are harmful to climate and 2. Natural refrigerants which not harmful to environment. So it is obvious and mandatory to move towards the use of natural refrigerants which have advantages on climate ozone layer. The Table 2 as shown below present the ODP and GWP of popular refrigerants.
Refrigerant | ODP (ozone depletion potential) | GWP (global warming potential) |
---|---|---|
CFC | High | Very High |
HCFC | Very Low | Very High |
HFC | Zero | High |
HC | Zero | Insignificant |
CO2 | Zero | Insignificant |
Helium used in Coolers | Zero | Zero |
ODP and GWP of popular refrigerants.
Green house gas emission is because of six potential gases. Green house gas emission in Oman during 2000’s was around 30 million metric tons [2]. Refrigerant leakage can be a small quantity, but it can be a considerable source of greenhouse gas emission. The below Table 3 show the common sources and their properties which are responsible for the greenhouse gas emission.
Symbol | Name | Common Sources |
---|---|---|
CO2 | Carbon Dioxide | Resultant gas from combustion, manufacture of cement products, Etc. |
CH4 | Methane | Landfills, manufacture and refining of natural gas and petroleum, fermentation from the digestive system of livestock, cultivation of rice, resultant gas from combustion, etc. |
N2O | Nitrous Oxide | Gas output from combustion, fertilizers, manufacture of nylon, manure, etc. |
HFC’s | Hydro fluoro carbons | Refrigerants, smelting of aluminum, manufacturing of semiconductor devices, etc. |
PFC’s | Fluorocarbons | Aluminum production, semiconductor industry, etc. |
SF6 | Sulfur Hexafluoride | Transmissions and distribution of electrical systems, circuit breakers, production of magnesium etc. |
Sources and properties of greenhouse gases.
Carbon di oxide is considered to be the knob of earth’s thermostat and it is an amazing tracer gas. Even a small change in the Co2 concentrations makes a big difference to the global surface temperature [3]. Greenhouse gases have the properties of active radiative or heat-trapping nature. Comparing the properties of greenhouse gases, are done by indexing them according to their Global Warming Potential. The ability of a GHG to trap heat in the atmosphere comparative to an equivalent quantity of carbon dioxide is called GWP. Carbon dioxide has the value one (1), though the most prevalent, is the least powerful GHG. So, the greenhouse gases are expressed in carbon dioxide equivalents. The unit of GWP potential is million metric tons (MMTCDE) of carbon dioxide and greenhouse gas emission from an electrical appliance can be calculated by using the formula,
Earth’s life is protected from sun’s harmful UV rays by ozone layer which is formed as a thin layer in the stratosphere. Ozone layer depletion was identified by the scientists during 1980. As a result of this, depletion of earth is likely to receive more amount of UV radiation, so that there is a strengthened chance of overexposure to UV radiation and the subsequent wellbeing effects. The below Figure 1 depicts the formation and destruction of ozone depletion process. The sun’s yield of UV B does not change. It is obvious that, less ozone means, more exposure of UV B radiation from the sun. The amount of UV B measured at the surface of Antarctic poles is two times during the annual ozone hole.
Ozone formation and depletion process.
Ozone layer is destroyed in the stratosphere 15 to 20 Km directly above the earth surface by CFC’s. Ozone concentrations are measured in Dobson units. 1 Dobson unit denotes 1 ozone molecule for every 1 billion air molecules. The meaning of ozone hole is the loss of ozone in a particular area. Greatest ozone hole is recorded in Antarctica continuously. The characteristics of ozone are, it is an allotrope of oxygen, and it is deadly to human beings if it is inhaled [4]. Human beings existence in the earth is very important and this is ensured by the protective layer ozone, as it filters or captivates ultra violet radiations which are usually short in wave length (280 – 320 nm). Ultra violet radiations can cause serious problems to humans such as sun burns, skin cancer, and eye disorders.
One of the chief characteristics of Chloro flouro carbons is, they do not dissolve in water and highly inert to water solubility. That is the reason they are not destroyed or dissolved even during in rain and stay in the atmosphere for many years and move slowly towards the stratosphere. The chloro flouro carbon molecules split off into chlorine atoms from the CFC molecules when they come in to contact with the ultra violet rays. The primary split of the CFC molecules are shown in the below equation.
Ozone layer is destroyed particularly by these single chlorine molecules.
Considerable amount of oxygen atoms are present in the stratosphere, because it produces oxygen atoms regularly by go through photo chemical breakdown. This will lead to the renewal of chlorine atoms in the stratosphere. So a lone CFC molecule can dismiss many ozone molecules.
Ozone was first discovered by a German chemist, Christian Friedrich in the year 1939. Ozone present in the stratosphere is formed by the chemical reactions between oxygen and sunlight. The production of stratospheric ozone is because of the chemical reaction balance.
One ozone molecule is broken into one oxygen molecule and the remaining oxygen molecule is absorbed by the ultra violet radiation [5]. The photochemistry of ozone depends on the interaction of sun’s radiation with the in atmospheric gases, particularly with oxygen.
A clear understanding of ozone layer was first assumed by Chapman in the year 1930. According to Chapman, when oxygen is hit by high energy photon, it is fragmented into two oxygen atoms. The below equation depicts Chapman’s reaction.
Where h = plank’s constant.
C = Speed of light (wavelengths shorter than 242 nano meters)
Ozone production by solar ultra violet radiation produce more amounts of ozone than the actual amount of ozone present in the atmosphere. The production of ozone is balanced by ozone loss.
UVB causes nonmelanoma skin cancer and plays a major role in malignant melanoma development and it is evident by many Laboratory and epidemiological studies. Also, UVB causes eye cataracts. In general, sunlight contains some UVB, even with normal ozone levels. And it is advisable that there should be always a limit to the exposure to sun.
Even a small amount of UV B radiation present in the sunlight will cause an impact in the physiological and evolving processes of plants. Damages to early developmental stages of fish, shrimp, crab, amphibians and other animals are caused by UV B rays. Some of the most severe effects of UV B radiation exposure to plants and animals are decrease in their reproduction capacity and reduced larval development. Even a small increase in UV (B) exposure could result in significant reduction in the size of the population of animals that eat these minor creatures.
CFC -12 is having high ODP and very high GWP. Promising substitutes for CFC-12 are hydro carbons which do not have any halogen compounds. The satisfactory characteristics of hydrocarbons are environmentally safe, energy efficient, technologically reliable refrigerants. Hydrocarbons arise naturally formed from solidified plant matter, and throughout the world initiate as oil and natural gas. Flammability is the characteristic feature of HC type refrigerants and it is the concerning point to be considered as a refrigerant in air conditioning and refrigeration systems, even though it exhibits very low GWP values [6].
Lower paraffin’s such as propane, butane, and isobutene were successfully used as refrigerant before the arrival of CFCs. The thermodynamic properties of the hydrocarbons are much better than any of the other alternatives to CFC’s. Hydrocarbons are available at low price all over the world and are compatible with commonly used lubricants and materials of construction used in refrigeration systems. Hydrocarbons are very economical and they are readily available in most parts of the world.
Using phase change materials in air conditioning systems can be an effective method for improving the process of cooling as well as minimizing the size of the system. The nature of phase change materials is they will absorb, store and release large amount of heat. Generally, the temperature of PCM increases with the increase in the ambient temperature. Researchers conducted various studies in using phase change materials for the use in air conditioning systems. Co2 emission and power consumption of the systems using phase change materials are better in comparison with the conventional systems [7]. Around 7% of electrical power consumption reduction was observed in the air conditioner designed by Nataohorn Chaiyat and Tanongkiat Kiatsiriroat with PCM bed in comparison with the normal air conditioner [8]. During the transition period, the PCM melts and so absorbs heat. A reverse process happens when the PCM temperature is decreased [7]. Thermodynamic properties of CFC and Hydrocarbons are mentioned in the below Table 4.
Refrigerant | Critical temp (°C) | Boiling temp (°C) | Density (kg/m3) | Heat of vaporization (kj/kg) |
---|---|---|---|---|
Propylene | 91.4 | −47.8 | 1.955 | 440.16 |
Propane | 96.8 | −42.1 | 2.019 | 425.92 |
I-Butylene | 146.6 | −6.3 | 2.550 | 391.58 |
Isobutylene | 144.7 | −7.0 | 2.500 | 397.02 |
Isobutene | 135.0 | −11.7 | 2.668 | 366.03 |
n-Butane | 152.0 | −0.5 | 2.703 | 387.81 |
R-12 | 112.0 | −29.7 | 6.240 | 166.0 |
Thermodynamic properties of CFC and hydro carbons.
Worldwide attempts are being made to eliminate the use of Chloro-fluorocarbons (CFCs) because chlorine released from CFCs migrates to the stratosphere and destroys the stratospheric ozone layer. An international treaty known as Montreal Protocol was formed to regulate the production and trade of ozone- depleting substances. Sultanate of Oman is one among the signatories of the Montreal Protocol. During July 2003 a workshop was organized by Ministry of Regional Municipalities, Environment & Water Resources in collaboration with the UNIDO and UNEP at Muscat to train the trainers to phase out the CFCs in Sultanate of Oman. The author was also one of the participants of the workshop. After the workshop it is felt to review the available literature of the various refrigerants, especially hydrocarbons, as alternative to CFCs and hence this article. This article is primarily intended to provide a brief summary about completed /going on works during the last toe decades to use hydrocarbon as refrigerants in commercial refrigeration systems.
Among the commonly used CFCs,
Though, the CFCs were characterized in 1890, but the development of fluorocarbon refrigerants was announced in 1930. Since then CFCs never looked back. Some of the historical highlights in the progress of refrigeration and the development of refrigerants are outlined in Table 5.
S.# | Year | Refrigerant | Comment. |
---|---|---|---|
1 | 1930 | The development of Fluorocarbon refrigerant was announced. | |
2 | 1931 | R-12 | Introduced as a commercial refrigerant. |
3 | 1932 | R-11 | Introduced as a commercial refrigerant. |
4 | 1933 | R-114 | Introduced as a commercial refrigerant. |
5 | 1934 | R-113 | Introduced as a commercial refrigerant. |
6 | 1936 | R-22 | Introduced as a commercial refrigerant. |
7 | 1943 | Mixture of R-11 & R-12 | Developed to use as an aerosol propellants |
8 | 1945 | R-13 | Introduced as a commercial refrigerant. |
9 | 1949 | R-500 | Patented by carrier corporation |
10 | 1952 | — | Manufacture of fluorocarbon refrigerants started by Allied Chemical Corporation. |
11 | 1955 | R-14 | Introduced as a commercial refrigerant. |
12 | 1957,1958, 1963 | Manufacture of fluorocarbon refrigerants started by other companies. | |
13 | 1961 | R-502 | Commercial Introduction of R-502 |
14 | 1975 | Mixture of R-12 & R-13 | Establishment of thermodynamic properties over the whole range of composition. |
Historical development of refrigerants.
The prevalent refrigerants and refrigerant mixtures from halogenated hydrocarbon family in use are R-11, R-12, R-13, R-14, R-22, R-113, R-114, R-500 and R-502. In developed countries various steps have been already taken to control the use of ozone depleting refrigerants. In developing countries conversion from CFCs to alternatives is still a major issue.
As per the recent guidelines from the Environment Protection Agency USA, phasing down of HFCs and manufacturing of alternate refrigerants to CFCs and HFCs is the most significant environment policy to be practiced globally [13].
Montreal Protocol asks for abandoning the use and production of ODS in phased manner. It currently has the following control schedules for chemicals used as refrigerants:\t\t
a phase out by 1.1.1996 of CFCs in the developed countries.
a grace period until 2010 for a CFC phase out in the countries operating under paragraph 1 of Article 5 (the developing countries), with a freeze in 1999 and gradual reduction steps thereafter.
a HCFC control schedule for the developed countries which requires gradual phase out of HCFCs over the period 1996 – 2020 (a freeze in 1996, a virtual phase out by 2020, a complete phase out by the year 2030), based upon a cap of 2.8% of the 1989 CFC consumption and the 1989 HCFC consumption (in ODP- tones);
a HCFC control schedule for the developing countries, which lags that of the developed countries by 10 years.
The Montreal Protocol does not address non-ozone depleting chemicals According to Mc Linden over thirty years of research and development will be required to arrive at and maintain the family of refrigerants which are being used today.
Global action plans and the action plans to reduce the use and step by step phasing out of HFC type refrigernats was agreed by all the countries under the 2015, Paris amendment. In the year 2016, in Kigali, Ruwanda, around 197 countries had accepted for an amendment for the phasing down of HFC type refrigerant which was recommended by the Montreal Protocol. Phasing down of HFC type refrigerants has to be completely executed within the next 30 years [13].
HFC-134a (Tetra fluro ethane) presently is the leading candidate to replace CFC-12. The main culprit chlorine atom is absent in the molecule of HFC-134a, hence this substance provides excellent chemical and thermal stability, significantly better than CFC-12.It has got zero Ozone Depleting Potential (ODP) and Global Warming Potential (GWP) of 0.115. All toxicological studies on HFC-134a have been completed including one-year inhalation study with favorable results. Wilson et al. conducted a detail study and reported the thermodynamic properties of HFC-134a. The thermodynamic properties of HFC-134a are very much similar to CFC-12. Normal boiling point (NBP) of HFC-134 a is – 26.8 deg. C which is very near to normal boiling point of CFC-12 (−29 .8 deg. C). McLinden considered the use of HFC-134a to be the most realistic refrigerant to CFC-12. Thermal conductivity and viscosity were measured over a temperature range temperatures and reported by Shank land et al. Lot of research works were carried out on different aspects of using HFC134a as a real substitute to CFC12. The use of oil in HFC 134 a systems requires a very stringent quality control. Some researchers reported that HFC-134a has been proved as a fully reliable refrigerant in retrofitting CFC-12 systems including centrifugal chillers, semi-hermetic reciprocating and screw compressors and HFC-134a is not the most suitable option for the hermetic systems.
Boot in his paper “Overview of Alternatives to CFCs for Domestic Refrigerators and Freezers” concluded that alternatives beyond HFC-134a must be considered owing to the inefficiency of HFC-134a when used in a refrigerator. Vineyard et al. performed tests with HFC-134a in a standard household refrigerator and concluded that HFC-134a consumes more energy than that of CFC-12. From the thermodynamic data, it can be estimated that HFC-134a has a lower capacity and operates at lower suction and higher discharge pressure than CFC-12 for the same evaporating and condensing temperatures. Based on this information, a larger compressor would be necessary to achieve capacities equivalent to those obtained with CFC-12.
Hydrocarbon refrigerants, which do not contain any halogen atom, are promising substitute for CFC-12. Hydrocarbons are environmentally safe, efficient, and technologically reliable refrigerants and insulation foam-blowing agents. Hydrocarbons are naturally occurring substances formed from fossilized plant matter, and found throughout the world as oil and natural gas. Lower paraffin’s such as propane, butane, and isobutene were successfully used as refrigerant before the advent of chlorofluorocarbons. The thermodynamic properties of the hydrocarbons are much better than any of the other alternatives known. (Refer the Table 4). Hydrocarbons are available at low price all over the world and are compatible with commonly used lubricants and materials of construction used in refrigeration systems. Hydrocarbons are relatively cheap to produce and they are readily available in most parts of the world.
The need to find substitutes for CFCs during the 1990s has led refrigeration industry back to using hydrocarbons which have no impact on the ozone layer and insignificant contribution to global warming. Since 1992, hydrocarbon refrigeration has become the technology of choice in many domestic markets in Western Europe. In Germany, 100 per cent of the industry has already converted to hydrocarbon technology. All of the major European companies, such as Bosch/Siemens, Electrolux, Liebherr, Miele, Quelle, Vest frost, Whirlpool, Bauknecht, Foron, and AEG are selling hydrocarbon refrigerators. They are available in many sizes, and a wide variety of models, including some with no-frost freezer compartments. There are over 100 different hydrocarbon refrigerator models on the European market.
The main drawback of these refrigerants is their high inflammability, which has prohibited their use. But modern innovations have greatly improved the safety of hydrocarbon technologies. Besides due to very low charge of hydrocarbons (the amount of propane or butane in a domestic hydrocarbon refrigerator is only 40 to 60 g equivalent to two to six cigarette lighters, depending on the size of the refrigerator) in small capacity refrigeration system inflammability does not present a problem The present level of technological development and safety measures available have made it possible to use hydrocarbons as working fluids in domestic refrigerators. Most consumers in Southern countries are already familiar with hydrocarbons in the form of LPG (liquid petroleum gas a propane and butane mix), as it is widely used for cooking in the home. According to Pearson of Star Refrigeration over 50 million refrigerators using hydrocarbon as a refrigerator have been produced and not a single accident due to flammability was reported. The main motivation to adopt hydrocarbons in spite of their high inflammability is their being
Propane has been tested in the small capacity refrigeration systems. Propane can be considered as an alternative for HCFC-22.The high latent heat requires low refrigerant charge in the system. The performance of propane is comparable to CFC-12 and HCFC-22 and considered to be better than HFC-134a. Granryd et al. designed a heat pump prototype with propane as refrigerant as an alternative to HCFC-22. Use of HFC 134 (a) will be decomposed as acids and poisonous substances, which is worse than the use of CFC. So use of natural refrigerants like hydro carbons was suggested by Lorentzen [6].
Cyclopropane is also a promising refrigerant for domestic refrigerators. Kim et al. carried out simulation and experimental studies using HC-270 as a refrigerant in a single evaporator refrigerator and found encouraging results with respect to energy consumption. It was reported that cyclopropane results in lower energy consumption by 6 to 7% and 17% increase in volumetric capacity as compared to CFC-12 single evaporator refrigerator.
Isobutane exhibits a higher normal boiling point (−11.85 deg. C) compared to CFC-12 (−29.8 deg. C) and requires about 80% larger displacement volume in the compressor than CFC-12 to obtain an equivalent cooling capacity. Ray Riffe et al. investigated the use of isobutane as a refrigerant in refrigerator/ freezer with the use of dual cycle (D.R, 1995). His conclusions were
For same refrigeration capacity, the amount of charge required by isobutene is 50% less than that of CFC-12.
In order to achieve the same cooling capacity as that of CFC-12, compressor is to be replaced with a larger displacement compressor.
Suction pressure (gauge) is slightly negative.
Noise level of Isobutane refrigerator is much lower in comparison to CFC-12, and Isobutane results are quite encouraging.
From the above discussion it is quite apparent that there are
Azeotropes are also known as constant boiling point mixtures. This class of refrigerant mixture
Azeotropes rigorously exist at only one composition for given temperature and pressure. However for all practical purposes, minor deviations are acceptable for many refrigerant systems. For this broader range the term ‘Near Azeotropic Mixture’ (
Non – Azeotropes are also called as zeotropes. A zeotropic blend is also a combination of two or more components. The components of this refrigerant have diverse boiling points. These components will evaporate and condense at unlike temperatures. In order to fully understand zeotropic blends we must also understand fractionation and glide [16].
Non-Azeotropes, which change their composition continuously during phase, change. These mixtures do not possess a sharp boiling point but boil over a range of temperature. This feature is intimately tied to the improvement of system’s efficiency if appropriate hardware changes are made to the system heat exchangers. The change of temperature with phase change is called Temperature Glide.
When heat transfer fluids exchange heat with Non Azeotropic Refrigerant Mixtures (NARMs) in a constant current flow mode, the thermodynamic irreversibility can be reduced by matching the temperature glide (NARM side) against the temperature drop (Heat Transfer Fluid side) resulting in an increase in the coefficient of performance.
As already stated, because of limitation of single fluids as alternative to CFC-12 and also the flexibility in modulating the capacity by varying the composition of the constituents, mixtures are emerging as a viable solution to CFC-12 alternatives.
Propane and Isobutane will combine pretty happily as both are non-polar. Butane molecules will be broken and are replaced by the molecules of butane and Propane molecules. Propane-isobutene mixture has the benefit of modulating the capacity to permit their use with compressor designed for use with CFC-12. The binary mixture ratio can conceivably be designed using boiling point as a guideline such that the disparate requirements of the freezer and the fresh food compartment in domestic refrigerators can be balanced. The normal boiling point temperature for HC-290/ HC-600a mixture (each 50% by mass) ranges from −32 deg. C to −24 deg. C which is very close to normal boiling point of CFC-12 [17].
The mixture in comparison to CFC-12 possesses very high latent heat of vaporization and low value of density (1/3 of CFC-12), which makes the mixture attractive because of its low charge requirement and circulation rates. The charge levels are approximately 40% that of CFC-12. One of the important advantages of R-600a/ R-290 blends is that it is compatible with mineral oils and commonly used materials for manufacturing of refrigeration systems and requires minimal changes in the refrigeration systems. The mixtures do not contain any halogen atom and hence the possibility of forming acids in the presence of moisture is eliminated [6].
This is also a factor for better stability of these mixtures. Table 4 shows the thermodynamic properties of few hydrocarbons and CFC-12. It follows from Table 4 that pure hydrocarbons cannot be exact alternative to CFC-12. Meyer conducted experimental investigation with the use of hydrocarbon refrigerants for domestic refrigerators. It was found that an unchanged CFC-12 single temperature refrigerator had lower energy consumption with a refrigerant mixture of 50% propane and 50% isobutene compared to CFC-12. Based on these encouraging results FORON decided to develop single temperature refrigerators using hydrocarbon mixtures as refrigerants. This was the beginning of use of hydrocarbon mixtures as refrigerants in domestic refrigerators. Domanski et al. carried out a study of hydrocarbon refrigerants for residential heat pump systems and concluded that these mixtures were promising substitute. He examined the various benefits and discussed the Rankine Cycle System and component design issues and limitations when using a wide range of single component refrigerants, hydrocarbons, with the help of the READER code for residential size heating and cooling systems (Domanki, 1994).
Liu et al. (1994) conducted an experimental test with propane-isobutane as a drop in substitute in a domestic refrigerator/freezer unit. They kept all hardware components of the refrigerator/freezer as that of CFC-12 except the capillary tube, which was, lengthen to control the flow rate. They concluded that highest savings of 6.5% were achieved with a blend of 70% HC-290 and 30% HC-600 with a charge of 70 g.Kruse performed a theoretical evaluation of hydrocarbons and its mixtures as refrigerants in refrigerators, unitary air conditioners and heat pumps. He concluded that in general,
When the Montreal Protocol has phased out CFCs in the developed countries and has a regulatory regime for the phase out of HCFCs, the problem still is a major problem in developing countries. Awareness is to be created among the common people to save the planet earth. Developing countries should phase out ozone depleting chemicals in a very careful manner.
Global market will continue to develop & introduce new refrigerant chemicals. Statutory requirement is necessary to control the UN –organized sector who are dealing in HVAC industry.
Every human being or a machine has a value. Mechanical machines are designed, fabricated and manufactured with different materials, and so cost is incurred for the manufacture of all the machineries. Almost all the residential air conditioners are vapor compression systems, which uses compressors. Compressor is the main component in any air conditioning system, and so it is the costliest component in an air conditioning system. Other components and the type of refrigerants used in the air conditioning systems will also contribute significantly to the total cost of the air conditioning system. The cost of one ton window air conditioner as an example is shown in the below Figure 2.
Cost of one ton of window air conditioner.
Cost incurred in the design and fabrication of constructal designed window air conditioner is shown in the below Figure 3. Here, the compressor was replaced with a pump and so the major part of the cost is reduced. Also the refrigerant materials, phase change material and water were industrial waste from the refineries and natural resource respectively.
Cost of Constructal designed window air conditioner.
CFC type refrigerants were used in window air conditioners, and now it is is completely phased out and replaced with HFC type HC (Hydro carbon) type refrigerants. It is difficult to fill in these refrigerants in the same system which used CFC type refrigerants. The system needs lot of design changes and the air conditioning service technicians carelessly releases the harmful CFC gases into the atmosphere. So, it is a good opportunity to retrofit the old window air conditioners with non CFC refrigerants. The total cost incurred for the fabrication of constructal designed window air conditioner was found to be around R. O 70/−, which was very much lesser than the normal vapor compression type window air conditioner. Cost can be further reduced by using the thrown away air conditioners and using the condenser and evaporator coils.
Cost of refrigerants as per the current selling prices in the refrigeration and air conditioning markets in Oman and India are presented below. Phase change materials can be extracted from the industrial waste from the petroleum refineries. Hence, there is a huge potential to recycle the industrial waste and thereby contributing indirectly to safe environment (Table 6).
Sl. No | Refrigerant name | Cost in INR | Cost in OMR | Cost USD |
---|---|---|---|---|
1 | R134 (a) | Rs 390/Kg | R.O 2.02/Kg | USD 5.96/Kg |
2 | R 22 | Rs 380/Kg | R.O 1.97/Kg | USD 5.13/Kg |
3 | R 404 | Rs 400/Kg | R.O 2.08/Kg | USD 5.39/Kg |
4 | R 410 (a) | Rs 350/Kg | R.O 1.82/Kg | USD 4.72/Kg |
5 | R 32 | Rs 395/Kg | R.O 2.05/Kg | USD 5.33/Kg |
6 | R 600 (a) | Rs 1000/Kg | R.O 5.19/Kg | USD 13.49/Kg |
7 | R414 (b) Hydrocarbon Blend | Rs 1250/Kg | R.O 6.49/Kg | USD 16.86/Kg |
8 | Phase Change Material | Rs 30/Lt | R.O 0.16/Kg | USD 0.40/Kg |
Cost of refrigerant materials.
Refrigerants are the key substances used in all the conventional refrigeration and air conditioning systems. Refrigerants rub though out the system and removes heat by changing its phases during the course of operation. Use of refrigerants evolved from the day of first refrigeration and air conditioning equipment. Air, carbon dioxide, ammonia, sulfur dioxide were used as refrigerants during the early day air conditioning systems. But because of the need in very low temperature applications and human comfort conditions, different artificial refrigerants were came into use. Significant artificial refrigerants are chloro flouro carbons (CFC), Hydro flouro carbons (HFC). Though the temperature produced by these refrigerants are very good for wide applications in residences and industries. But they contribute indirectly to the ozone layer damage and global warming.
To ensure the safety of environment, use of CFCs are banned and to be phased out completely as per the guidelines by Montreal Protocol. Even though, phasing out of CFCs and HFCs are not happening in developing countries, and so the threat to the environment continues. This chapter, introduces the use of phase change materials) PCM) as a potential refrigerant in air conditioning systems. Since phase change materials are thrown as waste byproducts from the petroleum refineries, use of PCMs in air conditioning systems will be additional contribution for the safety of environment.
cfc = chloro flouro carbon. | |
hc = hydro carbon | |
ac = air conditioner | |
keff = effective thermal conductivity | |
qpc = heat flux | |
rc = radius of centroid | |
α = void fraction | |
μ = viscosity of fluid | |
ρ = density of fluid | |
mmtcde = million metric tons of carbon dioxide equals | |
gwp = global warming potential |
The Internet has irrevocably changed the dynamics of scholarly communication and publishing. Consequently, we find it necessary to indicate, unambiguously, our definition of what we consider to be a published scientific work.
",metaTitle:"Prior Publication Policy",metaDescription:"Prior Publication Policy",metaKeywords:null,canonicalURL:"/page/prior-publication-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"A significant number of working papers, early drafts, and similar work in progress are openly shared online between members of the scientific community. It has become common to announce one’s own research on a personal website or a blog to gather comments and suggestions from other researchers. Such works and online postings are, indeed, published in the sense that they are made publicly available. However, this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
\\n\\nThe significance of Peer Review cannot be overstated when it comes to defining, in our terms, what constitutes a published scientific work. Peer Review is widely considered to be the cornerstone of modern publishing processes and the key value-adding contribution to a scholarly manuscript that a publisher can make.
\\n\\nOther than the issue of originality, research misconduct is another major issue that all publishers have to address. IntechOpen’s Retraction & Correction Policy and various publication ethics guidelines identify both redundant publication and (self)plagiarism to fall within the definition of research misconduct, thus constituting grounds for rejection or the issue of a Retraction if the work has already been published.
\\n\\nIn order to facilitate the tracking of a manuscript’s publishing history and its development from its earliest draft to the manuscript submitted, we encourage Authors to disclose any instances of a manuscript’s prior publication, whether it be through a conference presentation, a newspaper article, a working paper publicly available in a repository or a blog post.
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\\n\\nAll submitted manuscripts originating from a previously published conference paper must contain at least 50% of new original content to be accepted for review and considered for publication.
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\\n\\n2. NEWSPAPER & MAGAZINE ARTICLES
\\n\\nNewspaper and magazine articles usually do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense. Articles appearing in newspapers and magazines rarely possess the depth and structure characteristic of scholarly articles.
\\n\\nSubmitted manuscripts stemming from a previous newspaper or magazine article will be accepted for review and considered for publication. However, Authors are strongly advised to report any such publication in an accompanying note to the External Editor.
\\n\\nAs with the conference papers and presentations, Authors should obtain any necessary permissions from the newspaper or magazine that published the work, and indicate that they have done so in a note to the External Editor.
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\\n\\nAlthough such papers are regularly made publicly available via personal websites and institutional repositories, their general purpose is to gather comments and feedback from Authors’ colleagues in order to further improve a manuscript intended for future publication.
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\\n\\n4. SOCIAL MEDIA, BLOG & MESSAGE BOARD POSTINGS
\\n\\nWe feel that social media, blogs and message boards are generally used with the same intention as grey literature, to formulate ideas for a manuscript and gather early feedback from like-minded researchers in order to improve a particular piece of work before submitting it for publication. Therefore, we do not consider such internet postings to be publication in the scholarly sense.
\\n\\nNevertheless, Authors are encouraged to disclose the existence of any internet postings in which they outline and describe their research or posted passages of their manuscripts in a note to the Academic Editor. Please note that we will not strictly enforce this request in the same way that we would instructions we consider to be part of our conditions of acceptance for publication. We understand that it may be difficult to keep track of all one’s internet postings in which the researcher´s current work might be mentioned.
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\\n"}]'},components:[{type:"htmlEditorComponent",content:'A significant number of working papers, early drafts, and similar work in progress are openly shared online between members of the scientific community. It has become common to announce one’s own research on a personal website or a blog to gather comments and suggestions from other researchers. Such works and online postings are, indeed, published in the sense that they are made publicly available. However, this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
\n\nThe significance of Peer Review cannot be overstated when it comes to defining, in our terms, what constitutes a published scientific work. Peer Review is widely considered to be the cornerstone of modern publishing processes and the key value-adding contribution to a scholarly manuscript that a publisher can make.
\n\nOther than the issue of originality, research misconduct is another major issue that all publishers have to address. IntechOpen’s Retraction & Correction Policy and various publication ethics guidelines identify both redundant publication and (self)plagiarism to fall within the definition of research misconduct, thus constituting grounds for rejection or the issue of a Retraction if the work has already been published.
\n\nIn order to facilitate the tracking of a manuscript’s publishing history and its development from its earliest draft to the manuscript submitted, we encourage Authors to disclose any instances of a manuscript’s prior publication, whether it be through a conference presentation, a newspaper article, a working paper publicly available in a repository or a blog post.
\n\nA note to the Academic Editor containing detailed information about a submitted manuscript’s previous public availability is the preferred means of reporting prior publication. This helps us determine if there are any earlier versions of a manuscript that should be disclosed to our readers or if any of those earlier versions should be cited and listed in a manuscript’s references.
\n\nSome basic information about the editorial treatment of different varieties of prior publication is laid out below:
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\n\nGiven that conference papers and presentations generally pass through some sort of peer or editorial review, we consider them to be published in the accepted scholarly sense, particularly if they are published as a part of conference proceedings.
\n\nAll submitted manuscripts originating from a previously published conference paper must contain at least 50% of new original content to be accepted for review and considered for publication.
\n\nAuthors are required to report any links their manuscript might have with their earlier conference papers and presentations in a note to the Academic Editor, as well as in the manuscript itself. Additionally, Authors should obtain any necessary permissions from the publisher of their conference paper if copyright transfer occurred during the publishing process. Failure to do so may prevent Us from publishing an otherwise worthy work.
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\n\nNewspaper and magazine articles usually do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense. Articles appearing in newspapers and magazines rarely possess the depth and structure characteristic of scholarly articles.
\n\nSubmitted manuscripts stemming from a previous newspaper or magazine article will be accepted for review and considered for publication. However, Authors are strongly advised to report any such publication in an accompanying note to the External Editor.
\n\nAs with the conference papers and presentations, Authors should obtain any necessary permissions from the newspaper or magazine that published the work, and indicate that they have done so in a note to the External Editor.
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\n\nAlthough such papers are regularly made publicly available via personal websites and institutional repositories, their general purpose is to gather comments and feedback from Authors’ colleagues in order to further improve a manuscript intended for future publication.
\n\nWhen submitting their work, Authors are required to disclose the existence of any publicly available earlier drafts in a note to the Academic Editor. In cases where earlier drafts of the submitted version of the manuscript are publicly available, any overlap between the versions will generally not be considered an instance of self-plagiarism.
\n\n4. SOCIAL MEDIA, BLOG & MESSAGE BOARD POSTINGS
\n\nWe feel that social media, blogs and message boards are generally used with the same intention as grey literature, to formulate ideas for a manuscript and gather early feedback from like-minded researchers in order to improve a particular piece of work before submitting it for publication. Therefore, we do not consider such internet postings to be publication in the scholarly sense.
\n\nNevertheless, Authors are encouraged to disclose the existence of any internet postings in which they outline and describe their research or posted passages of their manuscripts in a note to the Academic Editor. Please note that we will not strictly enforce this request in the same way that we would instructions we consider to be part of our conditions of acceptance for publication. We understand that it may be difficult to keep track of all one’s internet postings in which the researcher´s current work might be mentioned.
\n\nIn cases where there is any overlap between the Author´s submitted manuscript and related internet postings, we will generally not consider it to be an instance of self-plagiarism. This also holds true for any co-Author as well.
\n\nFor more information on this policy please contact permissions@intechopen.com.
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