The district and major cities in East Java.
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"8250",leadTitle:null,fullTitle:"The Burden of Respiratory Syncytial Virus Infection in the Young",title:"The Burden of Respiratory Syncytial Virus Infection in the Young",subtitle:null,reviewType:"peer-reviewed",abstract:"Respiratory syncytial virus (RSV) causes seasonal epidemics during the winter and wet seasons, particularly in young children. Although there is one drug available for prophylaxis, palivizumab, it is indicated for high-risk children only. Therefore a vaccine is urgently needed. This book provides an overview of RSV and discusses its incidence and presentation in different populations, including preterm infants and children with congenital heart disease. It also discusses future strategies for RSV prophylaxis and developments in and barriers to creating a viable vaccine.",isbn:"978-1-78984-643-0",printIsbn:"978-1-78984-642-3",pdfIsbn:"978-1-83962-252-6",doi:"10.5772/intechopen.78206",price:119,priceEur:129,priceUsd:155,slug:"the-burden-of-respiratory-syncytial-virus-infection-in-the-young",numberOfPages:108,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"576eea34382b48ecff475d3f267837a2",bookSignature:"Bernhard Resch",publishedDate:"October 30th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/8250.jpg",numberOfDownloads:4816,numberOfWosCitations:6,numberOfCrossrefCitations:5,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:10,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:21,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 6th 2018",dateEndSecondStepPublish:"January 14th 2019",dateEndThirdStepPublish:"March 15th 2019",dateEndFourthStepPublish:"May 20th 2019",dateEndFifthStepPublish:"July 19th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"66173",title:"Prof.",name:"Bernhard",middleName:null,surname:"Resch",slug:"bernhard-resch",fullName:"Bernhard Resch",profilePictureURL:"https://mts.intechopen.com/storage/users/66173/images/system/66173.png",biography:"Born in Graz, Austria, Prof. Resch received his medical degree at the Karl-Franzens-University Graz in 1988. Following post-doc studies at the Division of Neonatology, and the Department of Pediatric Surgery of the University Hospital Graz, he became consultant of Pediatrics in 1997 and consultant of Neonatal and Pediatric Intensive Care Medicine in 2000. Since 2004, he is Professor of Pediatrics and since 2008, Head of the Research Unit of Neonatal Infectious Diseases and Epidemiology of the Medical University Graz. Since 2012 he is Deputy Head of the Division of Neonatology of the Medical University of Graz. His main research fields include neonatal infectious diseases, RSV infection, periventricular leukomalacia of the preterm infant, the neonatal microbiome and the role of probiotics.\nHe is a member and board member of several scientific societies including ESPID, past president of the Austrian Society of Perinatal Medicine, and member of the editorial board of several international journals including 'BMC Infectious Diseases' and 'Frontiers in Pediatrics'",institutionString:"Medical University of Graz",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Medical University of Graz",institutionURL:null,country:{name:"Austria"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1047",title:"Pulmonology",slug:"pulmonology"}],chapters:[{id:"68674",title:"Disease Severity in Respiratory Syncytial Virus Infection: Role of Viral and Host Factors",doi:"10.5772/intechopen.88782",slug:"disease-severity-in-respiratory-syncytial-virus-infection-role-of-viral-and-host-factors",totalDownloads:770,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Respiratory syncytial virus (RSV) is not only a major cause of severe lower respiratory tract infection (LRTI) in infancy but is increasingly recognised as an important pathogen in later life. RSV infection is associated with a wide spectrum of disease ranging from asymptomatic infection to life-threatening bronchiolitis and pneumonia. Research has demonstrated that there exists a complex interplay between viral and host factors that determines the severity of disease following RSV infection. Several factors determine RSV virulence including the infective properties of individual strains and viral load (VL). Disease outcome from RSV infection is also impacted considerably by a variety of host factors with the host immune response increasingly recognised as pivotal. This chapter outlines our current understanding of these factors and provides an oversight of their relative importance.",signatures:"Julian P. Legg",downloadPdfUrl:"/chapter/pdf-download/68674",previewPdfUrl:"/chapter/pdf-preview/68674",authors:[{id:"290959",title:"Dr.",name:"Julian",surname:"Legg",slug:"julian-legg",fullName:"Julian Legg"},{id:"409527",title:"Dr.",name:"Julian P.",surname:"Legg",slug:"julian-p.-legg",fullName:"Julian P. Legg"}],corrections:null},{id:"66054",title:"Resolving the Debate on RSV Prophylaxis in Late Preterm Infants",doi:"10.5772/intechopen.85073",slug:"resolving-the-debate-on-rsv-prophylaxis-in-late-preterm-infants",totalDownloads:818,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"There is still active debate in the scientific literature about the importance of providing respiratory syncytial virus (RSV) prophylaxis to late preterm infants born at 33–35 weeks’ gestational age (wGA). The American Academy of Pediatrics and the Canadian Paediatric Society position statements only advocate for RSV prophylaxis for infants <30 wGA. Several publications prove the contrary, reporting substantial morbidity and even mortality in older GA infants, following RSV infection. Consequently, other Societies, such as from Spain and Italy, have different criteria, and include as candidates 30–32 wGA infants and 33–35 wGA infants with risk factors for severe RSV disease. This chapter will systematically examine the current evidence for RSV prophylaxis in both early and late preterm infants 29–35 wGA and the cost-effectiveness of this strategy with the use of risk scoring tools. The authors will attempt to reconcile the misconception that late preterm infants do not merit RSV prophylaxis and hopefully resolve the long-standing debate that currently exists in many countries worldwide.",signatures:"Bosco Paes, Barry Rodgers-Gray and Xavier Carbonell-Estrany",downloadPdfUrl:"/chapter/pdf-download/66054",previewPdfUrl:"/chapter/pdf-preview/66054",authors:[{id:"287108",title:"Dr.",name:"Barry",surname:"Rodgers-Gray",slug:"barry-rodgers-gray",fullName:"Barry Rodgers-Gray"},{id:"287110",title:"Dr.",name:"Bosco",surname:"Paes",slug:"bosco-paes",fullName:"Bosco Paes"},{id:"287130",title:"Prof.",name:"Xavier",surname:"Carbonell-Estrany",slug:"xavier-carbonell-estrany",fullName:"Xavier Carbonell-Estrany"},{id:"406705",title:"Dr.",name:"Bosco",surname:"Paes",slug:"bosco-paes",fullName:"Bosco Paes"},{id:"406706",title:"Dr.",name:"Barry",surname:"Rodgers-Gray",slug:"barry-rodgers-gray",fullName:"Barry Rodgers-Gray"},{id:"406707",title:"Dr.",name:"Xavier",surname:"Carbonell-Estrany",slug:"xavier-carbonell-estrany",fullName:"Xavier Carbonell-Estrany"}],corrections:null},{id:"66450",title:"Respiratory Syncytial Virus Infections among Children with Congenital Heart Disease",doi:"10.5772/intechopen.85552",slug:"respiratory-syncytial-virus-infections-among-children-with-congenital-heart-disease",totalDownloads:992,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Infants and children suffering from congenital heart disease represent a patient cohort particularly at risk for severe RSV infections. Most notably the complication rates in lower respiratory tract infections due to RSV among patients with congenital heart disease are significantly higher compared to other patient collectives. Predisposing factors are altered lung mechanics caused by either increased or decreased pulmonary blood flow, both resulting in a ventilation/perfusion mismatch causing decreased pulmonary compliance and higher airway resistance. Randomized controlled trials have shown that immunoprophylaxis with palivizumab is beneficial for CHD patients. Guidelines from different national societies suggest administration of palivizumab for infants with CHD in young age injected monthly throughout the RSV season, if the CHD is considered hemodynamically significant.",signatures:"Maja Daurach and Ina Michel-Behnke",downloadPdfUrl:"/chapter/pdf-download/66450",previewPdfUrl:"/chapter/pdf-preview/66450",authors:[{id:"288835",title:"Dr.",name:"Maja",surname:"Daurach",slug:"maja-daurach",fullName:"Maja Daurach"},{id:"407393",title:"Dr.",name:"Maja",surname:"Daurach",slug:"maja-daurach",fullName:"Maja Daurach"},{id:"407394",title:"Dr.",name:"Ina",surname:"Michel-Behnke",slug:"ina-michel-behnke",fullName:"Ina Michel-Behnke"}],corrections:null},{id:"65931",title:"RSV: Available Prophylactic Options and Vaccines in Clinical Trials",doi:"10.5772/intechopen.84851",slug:"rsv-available-prophylactic-options-and-vaccines-in-clinical-trials",totalDownloads:1018,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Respiratory syncytial virus (RSV) is the leading cause of serious lower respiratory infection (ALRI)-related hospitalization in children worldwide, and a source of morbidity and mortality in high-risk adults. There are strong associations between RSV, persistent wheezing and childhood asthma. Despite extensive research, no effective treatment is available aside from supportive care. The trial of a formalin-inactivated RSV vaccine in the 1960s resulted in priming the severe illness upon natural infection. Palivizumab, a monoclonal antibody approved for RSV prophylaxis in high-risk infants, has only moderately decreased hospital admissions due to RSV infection. Live-attenuated, vector, and protein-based vaccine candidates are being investigated in many clinical trials. Developing a vaccine remains challenging due to finding the right balance between adequate immunogenicity and attenuation of vaccine. Here we review the clinical significance of RSV in infants, young children, high-risk adults, elderly population, pregnant women; clinical manifestations and consequences of RSV infection; the pharmacologic strategies currently available, the current stages of RSV vaccine clinical trials, different strategies, and major hurdles in the development of an effective RSV vaccine.",signatures:"Debra T. Linfield and Fariba Rezaee",downloadPdfUrl:"/chapter/pdf-download/65931",previewPdfUrl:"/chapter/pdf-preview/65931",authors:[{id:"287189",title:"Dr.",name:"Fariba",surname:"Rezaee",slug:"fariba-rezaee",fullName:"Fariba Rezaee"},{id:"287519",title:"BSc.",name:"Debra",surname:"Linfield",slug:"debra-linfield",fullName:"Debra Linfield"},{id:"406495",title:"Dr.",name:"Debra T.",surname:"Linfield",slug:"debra-t.-linfield",fullName:"Debra T. Linfield"},{id:"406496",title:"Dr.",name:"Fariba",surname:"Rezaee",slug:"fariba-rezaee",fullName:"Fariba Rezaee"}],corrections:null},{id:"68404",title:"Hurdles in Vaccine Development against Respiratory Syncytial Virus",doi:"10.5772/intechopen.87126",slug:"hurdles-in-vaccine-development-against-respiratory-syncytial-virus",totalDownloads:1218,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:1,abstract:"Respiratory syncytial virus (RSV) infection is a major cause of severe respiratory disease in infants and young children worldwide and also forms a serious threat for the elderly. Vaccination could significantly relieve the burden of the RSV disease. However, unfortunately there is no licensed vaccine available so far. This is partly due to disastrous outcome of a clinical trial of formalin-inactivated RSV (FI-RSV) in children in 1960s; leading to enhanced respiratory disease upon natural infection. These findings contributed significantly to the delay of RSV vaccine development. Other key obstacles in development of RSV vaccine such as a peak of severe disease at 2–3 months of age, challenging biochemical behavior of key vaccine antigens and dependence on animal models that may not truly reflect human disease processes. These challenges could be overcome through maternal immunization, structure-based engineering of vaccine antigens, the design of a novel platform for safe infant immunization, and the development of improved animal models. Currently, several vaccine candidates are in pre-clinical and clinical trials targeting the diverse age groups; young children or older adults from the infection or can reduce incidence, mortality and morbidity among the RSV infected individuals.",signatures:"Muhammad Shafique, Muhammad Asif Zahoor, Muhammad Imran Arshad, Bilal Aslam, Abu Baker Siddique, Muhammad Hidayat Rasool, Muhammad Usman Qamar and Muhammad Usman",downloadPdfUrl:"/chapter/pdf-download/68404",previewPdfUrl:"/chapter/pdf-preview/68404",authors:[{id:"201590",title:"Dr.",name:"Bilal",surname:"Aslam",slug:"bilal-aslam",fullName:"Bilal Aslam"},{id:"224512",title:"Dr.",name:"Muhammad Asif",surname:"Zahoor",slug:"muhammad-asif-zahoor",fullName:"Muhammad Asif Zahoor"},{id:"229168",title:"Dr.",name:"Abu Baker",surname:"Siddique",slug:"abu-baker-siddique",fullName:"Abu Baker Siddique"},{id:"229169",title:"Dr.",name:"Muhammad",surname:"Shafique",slug:"muhammad-shafique",fullName:"Muhammad Shafique"},{id:"261133",title:"Dr.",name:"Muhammad Hidayat",surname:"Rasool",slug:"muhammad-hidayat-rasool",fullName:"Muhammad Hidayat Rasool"},{id:"288062",title:"Dr.",name:"Muhammad Imran",surname:"Arshad",slug:"muhammad-imran-arshad",fullName:"Muhammad Imran Arshad"},{id:"303654",title:"Dr.",name:"Muhammad Usman",surname:"Qamar",slug:"muhammad-usman-qamar",fullName:"Muhammad Usman Qamar"},{id:"303655",title:"Mr.",name:"Muhammad",surname:"Usman",slug:"muhammad-usman",fullName:"Muhammad Usman"},{id:"409438",title:"Dr.",name:"Muhammad",surname:"Shafique",slug:"muhammad-shafique",fullName:"Muhammad Shafique"},{id:"409439",title:"Dr.",name:"Muhammad Asif",surname:"Zahoor",slug:"muhammad-asif-zahoor",fullName:"Muhammad Asif Zahoor"},{id:"409440",title:"Dr.",name:"Muhammad Imran",surname:"Arshad",slug:"muhammad-imran-arshad",fullName:"Muhammad Imran Arshad"},{id:"409441",title:"Dr.",name:"Bilal",surname:"Aslam",slug:"bilal-aslam",fullName:"Bilal Aslam"},{id:"409442",title:"Dr.",name:"Abu Baker",surname:"Siddique",slug:"abu-baker-siddique",fullName:"Abu Baker Siddique"},{id:"409443",title:"Dr.",name:"Muhammad Hidayat",surname:"Rasool",slug:"muhammad-hidayat-rasool",fullName:"Muhammad Hidayat Rasool"},{id:"409444",title:"Dr.",name:"Muhammad Usman",surname:"Qamar",slug:"muhammad-usman-qamar",fullName:"Muhammad Usman Qamar"},{id:"409445",title:"Dr.",name:"Muhammad",surname:"Usman",slug:"muhammad-usman",fullName:"Muhammad Usman"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"990",title:"Human Respiratory Syncytial Virus Infection",subtitle:null,isOpenForSubmission:!1,hash:"b5d980a120eec6669c7f37a5082f0696",slug:"human-respiratory-syncytial-virus-infection",bookSignature:"Bernhard Resch",coverURL:"https://cdn.intechopen.com/books/images_new/990.jpg",editedByType:"Edited 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\r\n\tCartilage lesions of the knee are common and should be treated correctly if symptomatic. Until now, multiple (surgical) techniques have been described; however, there is no consensus on which one should be used. Also, treatment techniques using platelet-rich plasma, mesenchymal stem cells, and different king of growth hormones have been mentioned. In this book, the importance of other knee structures when treating these knee cartilage defects will be discussed as the meniscus, integrity of ligaments, and the importance of the alignment of the lower limb will be emphasized. The book will give an update on the different treatment approaches in knees with this (osteo-)chondral lesion.
",isbn:"978-1-83768-204-1",printIsbn:"978-1-83769-984-1",pdfIsbn:"978-1-83768-205-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"90b8cac7c6b437387a540790d072699f",bookSignature:"Dr. Karl Almqvist, Dr. Ahmed Ebrahim El Hamaky and Dr. Taiceer Abdulwahab",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11693.jpg",keywords:"Defect, Cartilage Function, Subchondral Bone, Envelope of Function, Alignment, Knee Stability, Meniscal Function, Surgical Treatment, Microfracture, Use of Scaffolds, Debridement",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 4th 2022",dateEndSecondStepPublish:"July 7th 2022",dateEndThirdStepPublish:"September 5th 2022",dateEndFourthStepPublish:"November 24th 2022",dateEndFifthStepPublish:"January 23rd 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"An experienced researcher, specializing in sports medicine and knee pathologies, is currently involved in the development of innovative techniques for the treatment of cartilage lesions. Dr. Almqvist is an editorial board member at Sage Journals, Affiliated with the Orthocure Clinic, Dubai as an Orthopedic Consultant, Mediclinic City Hospital as a Consultant Orthopaedic surgeon, and is a member of ISAKOS.",coeditorOneBiosketch:"Dr. El Hamaky is a practitioner with over 11 years of experience in Orthopedic Surgery, is a member of the Egyptian Board of Orthopedic Surgery, a member of the AO Foundation, and was awarded his medical degree from the University of Cairo.",coeditorTwoBiosketch:"Dr. Taiceer Abdulwahab is an experienced practitioner, specializing in orthopedic surgery, trauma, and sports medicine, previously affiliated with The University of Bristol, The University of Edinburgh, The University of Warwick, and The University of Leicester, and is a member of the Royal College of Surgeons (MRCS) London, UK.",coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"251312",title:"Dr.",name:"Karl",middleName:null,surname:"Almqvist",slug:"karl-almqvist",fullName:"Karl Almqvist",profilePictureURL:"https://mts.intechopen.com/storage/users/251312/images/system/251312.jpg",biography:"Prof. Dr. Almqvist trained at the University of Ghent in Belgium and worked at the Ghent University Hospital where he was Head of Clinic, Department of Physical Medicine and Orthopaedic Surgery, prior to moving to Dubai in 2014. He also has considerable teaching experience and is an assistant professor in Physiotherapy and Orthopaedic Surgery at Ghent University. Karl Fredrik has published extensively and written a number of book chapters. He is a regular speaker at international meetings and is on the editorial board or is a reviewer for the major sports orthopedic journals.\r\nHe obtained his Ph.D. in 2001 (Human differentiated articular cartilage cells in biodegradable matrices – Preparative studies for their use in the repair of cartilage defects).\r\nKarl Fredrik is active in a number of orthopaedic organisations, and is the past Chairman of the Sports Committee of the International Society of Arthroscopy, Knee Surgery & Orthopaedic Sports Medicine as well as the past Chairman of the Cartilage Committee of the European Society of Sports Traumatology, Knee Surgery & Arthroscopy.\r\nThe main area of interest Karl Fredrik is knee surgery. His expertise covers the whole range of knee conditions from sports injuries to knee replacement.",institutionString:"Orthocure Dubai",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null}],coeditorOne:{id:"452670",title:"Dr.",name:"Ahmed",middleName:null,surname:"Ebrahim El Hamaky",slug:"ahmed-ebrahim-el-hamaky",fullName:"Ahmed Ebrahim El Hamaky",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003N9dpTQAR/Profile_Picture_2022-03-04T13:32:24.jpg",biography:"An orthopedic surgeon with 11 years experience in orthopedic surgery, trained in highly specialized facilities in Egypt such as Al kasr al ainy University hospitals, Al Helal Orthopedic tertiary hospital, Air force specialized hospital. His interest and specialty are mainly sports medicine and surgery either shoulder or knee arthroscopic and primary arthroplasty surgeries. He shifted his career to Dubai Mediclinic City Hospital, Dubai.",institutionString:"Mediclinic City Hospital",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Mediclinic City Hospital",institutionURL:null,country:{name:"United Arab Emirates"}}},coeditorTwo:{id:"204153",title:"Dr.",name:"Taiceer",middleName:null,surname:"Abdulwahab",slug:"taiceer-abdulwahab",fullName:"Taiceer Abdulwahab",profilePictureURL:"https://mts.intechopen.com/storage/users/204153/images/system/204153.jpeg",biography:"Dr. Taiceer Abdulwahab, is an Orthopaedic Surgeon at Mediclinic City Hospital, Dubai, United Arab Emirates. He is also an Assistant Clinical Professor of Orthopaedic Surgery at Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai.\r\nHe is a Master of Surgery (ChM) in Trauma & Orthopaedic Surgery, degree obtained at the University of Edinburgh School of Medicine in partnership with the Royal College of Surgeons of Edinburgh, UK. He received his Master of Science (MSc) in Trauma & Orthopaedic Surgery degree from Warwick School of Medicine, University of Warwick, UK. He also received a Postgraduate Award (PGA) in Understanding Research & Critical Appraisal at the Warwick School of Medicine, University of Warwick, UK.\r\nDr. Abdulwahab obtained his primary medical qualification, Bachelor of Medicine & Bachelor of Surgery (MBChB) from the Bristol School of Medicine, University of Bristol, UK.\r\nDr. Taiceer Abdulwahab is a Member of the Royal College of Surgeons of England (MRCS).\r\nHe has presented at various international conferences including the International Congress for Joint Arthroplasty (ICJR) and the European College of Sports & Exercise Physicians (ECOSEP) with FIFA update, as well as published in peer-reviewed journals, Editor for a book titled 'Meniscus of the Knee', and investigator in several randomized controlled trials.\r\nHe is Trauma Doctor for the annual Emirates Rugby 7s.\r\nHe has a special interest in Sports Surgery (Arthroscopic Shoulder and Knee surgery).",institutionString:"Mediclinic City Hospital",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Mediclinic City Hospital",institutionURL:null,country:{name:"United Arab Emirates"}}},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"466998",firstName:"Dragan",lastName:"Miljak",middleName:"Anton",title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/466998/images/21564_n.jpg",email:"dragan@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. 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In order to develop such models, very accurate experimental data are necessary for selected complex mixtures, such as those that exist in natural gas. For this reason researchers must collect the most important and fundamental thermodynamics properties for such systems. Two of the most important thermodynamics properties are the pressure volume (density) and temperature (P
When natural gas rises from the reservoir to the ocean floor at offshore platforms, the stream temperature can drop quickly (perhaps 5 to 10 °C) until it reaches the surrounding ocean temperature. This rapid temperature drop at high pressure along with moisture in the natural gas stream make conditions favorable for gas hydrate formation in the pipeline. Hydrates can cause several serious problems such as: plugging the pipeline and blowouts [2]. Similar problems are as well common in natural gas compression facilities at offshore and onshore processing plants. Such problems can be avoided by increasing the temperature and insulating the stream that comes from the ocean bed, or by lowering the pressure of the pipeline. Another possible solution is lowering the dew point of water in the stream by adding polar solvents to the line such as methanol or glycols. In order to apply all these methods, accurate knowledge on P
Because of their importance, density measurements essential for both industrial applications and scientific research. Very accurate P
Knowledge of temperature, pressure and composition enables determination of the density from an EOS. The equation most widely used in custody transfer of natural gas is the Detailed Characterization Method or AGA8-DC92 EOS developed by American Gas Association (AGA) in 1992 [4]. This EOS was derived using an extensive and reliable experimental P
AGA8-DC92 EOS uncertainty regions [
As seen in Figure 1, the maximum uncertainty claimed for the EOS is 0.1% in region 1, 0.3% in region 2, 0.5% in region 3 and 1.0% in region 4. However, the equation is valid only for lean natural gas mixtures over this wide range of conditions, and its ability to describe rich natural gases is untested. The equation cannot perform equilibrium calculations, as it is only valid for gas phase calculations. Also, use of the equation is not recommended near the critical point. The deviations from density measurements are 2 to 2.5% for North Sea natural gas samples at 8 to 17 MPa and 40 to 80 °C [6]. Following this, the Gas Research Institute (GRI) and National Engineering Laboratory (NEL) started a collaborative, joint industry project to extend the range of applicability of AGA8-DC92 EOS for natural gas mixtures to include the gas compositions observed in the North Sea. GERG-2008 EOS is the latest benchmark EOS that addresses the drawbacks of AGA8-DC92 EOS and it has proven to have better uncertainty in P
This section contains reviews of several experimental methods for density measurements, and discusses the relative strengths and weakness of each method. An EOS can describe the thermodynamic state or vapor liquid equilibrium (VLE) of pure fluids and mixtures with accuracy that depends upon the application. The accuracy of an EOS depends upon the experimental data used during development of the equation. Historically, the quality of predictions obtained from EOS has improved dramatically as advanced technologies and new instrumentation have become more common for experimental methods. Among the thermodynamic properties, density is the most directly predicted property using EOS. The measured densities should be approximated by suitable EOS and the measurements should be traceable to the International System of Units [8]. According to Kleinrahm et. al. [9], the following considerations are important when deciding upon a density measurement technique:
Large pressure and temperature range for wide operations.
Low total uncertainty and high accuracy of the method for the overall range.
Simplicity in design and ease of maintenance and operation.
Little time required for each data point measurement.
Several different density-measurement techniques are described in this section, including: speed of sound methods, vibrating body techniques, continuous weighing method and buoyancy-based densimeters.
Speed of sound measurements can be used to determine the performance of an equation of state for thermodynamics property predictions. By correlating the speed of sound to thermodynamics properties, one can build experimental devices and investigate solid, liquid and gas thermodynamics properties for pure components and mixtures. Densities and isothermal and isentropic compressibility factors result from speed of sound measurements experiments [10]. Based upon a pulse technique described by Daridon et. al. [11], a cylindrical-shaped cell is used to measure ultrasonic waves. In the pulse technique, effects of pressure upon piezo-electric materials are isolated by separating piezo-electric elements from the fluid studied. The speed results from the measurements of the transit time through the sample and the length of passage, which is a function of temperature and pressure. Density comes from:
In above equation u is the sound speed, α is the isobaric coefficient of thermal expansion,
Vibrating tubes and vibrating forks are common density measuring techniques. These devices measure the fluid density of interest by determining the oscillation frequency of the vibrating element in the fluid. These instruments provide accurate results quickly. However, frequent calibration is necessary for this apparatus to maintain its accuracy [12]. Moreover, when the density of the fluid is vastly different from air or pure water (frequently used as reference fluids because of their well-known thermophysical properties) the uncertainty of the measurements increases as reported by Kuramoto et al. [8].
2.2.2.1. Vibrating wires
In vibrating wire densimeters, a wire carrying a diamagnetic weight is suspended in the fluid to be monitored. The wire is placed in a robust position in a uniform magnetic field provided by permanent magnet in both vertical and horizontal directions. When an alternating current passes through the power source to the wire, interaction starts with the current and the magnetic field. This leads to induced harmonic motion that is orthogonal to the magnetic field and the wire. If the mass, density and the dimension of all the solid components of the system are known, the resonant frequency of the wire can be determined experimentally under vacuum conditions. If the viscosity of the fluid of interest is known, experimental measurement of resonant frequency of wire velocity provides the fluid density [13; 14]. Although the vibrating wire technique is suitable for a wide range of pure fluid and mixture gas density applications, it suffers from problems such as surface tension on the wire, adsorption on the weight, detailed knowledge need of exact dimensions of the wire and the assembly. However, the device is used widely as a primary densimeter device because it has a simple operating principle and allows development of an exact physical model. Density, in principle, can be calculated directly from the theory.
2.2.2.2. Vibrating tubes
Vibrating tube densimeters consist of an assembly that includes two thin walled metallic or glass tubes bent in Y or V shapes as shown in figure 2. A permanent magnet and drive coil reside between these two tubes. Generally, a drive coil and a permanent magnet are placed in the middle of the two tubes. The drive coils and magnet are mounted on the opposite legs of the tubes. Each coil and magnet on the side leg forms a pick-off circuit. Alternatively, attractive and repulsive magnetic fields between the coils and magnets are provided by sending alternating current to the drive coil.
Vibrating tube densimeter scheme.
Because the drive coils and the magnets are installed on the opposing side of the tubes, a sine wave generated by the two pick-up circuits represents the motion of one tube relative to the other. The sine waves are in phase if there is no flow in the tube. The density of the fluid is:
where, tube parameters
where subscript
Another well-established and widely-used density measurement device is the Burnett apparatus. Burnett [15] suggested a technique to measure the densities of sample fluids without measuring the mass or volume directly. An expansion device contains two cells. During operation, the sample is charged initially into the first cell and, after pressure and temperature measurement, expanded into the second cell. The ratio of the final volume to the original volume equals the ratio of densities before and after the expansion. Only pressure and temperature are measured before and after expansion of the sample from a single volume (VA) into the combination of the original volume and a second volume (VA+VB). Some of the gas goes through a sequence of isothermal expansions into a chamber, which is evacuated every time the expansion takes place. Both virial coefficient and gas density can be calculated with this method. The ratio of the densities before and after the expansion is calculated for each expansion:
where
In equation 4,
In the continuously weighed pycnometer method, the mass of the sample is determined by direct weighing of the cell. A typical pycnometer consists of a weight measurement system, constant temperature bath, temperature control system and data acquisition system, a volume bellows cell for changing pressure and density without transferring mass, and a high vacuum system [19]. The major component of this method is a constant volume pycnometer suspended from a digital balance. The pycnometer can be filled and evacuated with an extension tube that enables faster measurements and reduces operator errors. The mass of the pycnometer when empty and when filled with fluid is measured by a digital balance. The density of the fluid being measured at constant temperature and pressure is calculated from the measured mass value of the fluid and the known volume of the pycnometer. One disadvantage of this method is that the long feed tube exposes part of the sample to ambient temperature making it impossible to measure mixture densities when the sample exists as one phase at the cell set point temperature and at room temperature.
The hydrostatic buoyancy force technique is based upon Archimedes’ Principle. Basically, Archimedes’ Principle states “when a solid body is immersed in a fluid, it displaces a volume of fluid the weight of which is equal to the buoyancy force exerted by the fluid on the sinker.” This means that the buoyancy force is proportional to the density of the fluid in the measuring cell under pressure. This principle can be applied to determine the gas density of any pure fluid or mixture. Historically, improvements have appeared in the application of buoyancy method based densimeters.
2.2.5.1. Classical methods
In classical hydrostatic buoyancy densimeters, an object (sinker hereafter), usually a sphere or cylinder, is suspended from a commercial digital balance by a thin wire. The fluid is kept in a pressure cell at constant temperature using a temperature control mechanism. The sinker is submerged in the fluid and weight of the sinker is constantly monitored. According to Archimedes’ principal, the apparent loss in the true weight of the sinker is equal to the weight of the displaced fluid. Density of the fluid results from:
In above equation
2.2.5.2. Magnetic suspension devices
To overcome limitations in achievable accuracy, the need for frequent calibration of the apparatus with reference fluids, complexity of operation, limitations on temperature and pressure, Kleinrahm and Wagner [9] introduced an MSD based upon magnetic levitation of the sinker in the measuring cell. The novelty of the magnetic suspension coupling was that it used non-physical-contact force transmission between the sinker in the pressurized cell and the weighing balance at atmospheric pressure, thus allowing a cell design that covered a very wide temperature and pressure range [21]. Then, Kleinrahm and Wagner [20] modified the hydrostatic buoyancy force method by introducing an alternative force transmission method in which they levitated two sinkers through a magnetic suspension coupling. By compensation for surface tension, buoyancy, adsorption effects and shifts in zero-point of the balance, a two-sinker MSD improved the accuracy of the density measurements.
Operation of a two-sinker MSD is rather complex and its advantage is not required for medium or high-density measurements encountered in many practical applications. To extend the instrument range towards higher temperatures and pressures, Wagner et al. [16] have developed a single-sinker densimeter. Although the single sinker design is much simpler than that of the two-sinker densimeter, it is still possible to perform high-accuracy density measurements at relatively low gas densities by applying some of the advantageous features of the two sinker device [22]. The single-sinker densimeter also operates based upon Archimedes’ principle and the force transmission comes from levitation of the sinker in the measuring housing of the high-pressure cell. Klimeck
Viscosity is a remarkable property for natural gas because of its influence on flow behavior, which is especially important for reservoir conditions. Natural gas viscosity is several orders of magnitude lower than for oil or water, and thus, natural gas mobility in reservoirs is larger than for water or oil. Moreover, gas flow is predominantly laminar in reservoirs, and thus, the influence of viscosity is especially important. The upstream gas industry faces new challenges for precision monitoring of gas supplies, for which accurate and reliable knowledge of the natural gas viscosity is a prerequisite. Davani et al. [24] and Denney [25] analyzed the gas viscosity estimation errors on the gas recovery from a high pressure-high temperature (HPHT) reservoir, showing that a -10 % error in gas viscosity estimation can produce a relative 8.22 % error in estimated cumulative gas production, and a + 10 % error can lead to a relative 5.5 % error in cumulative production. Moreover, uncertainty in gas viscosity data has a direct effect for inflow performance relationship curves [26], Davani et al. [27] showed that a 1 % uncertainty in gas viscosity data leads to a 1 % uncertainty in gas flow rate.
Sanjari et al. [28] reported in recent study that common prediction methods for natural gas viscosity lead to large deviations when applied for high pressure – high temperature ranges, and thus, these methods should be applied with caution for reservoir estimations. This lack of accuracy for current predictive viscosity models, and the large economical impact of viscosity uncertainties, show the need of experimental accurate natural gas viscosity to analyze
Experimental accurate measurement of gas viscosity is very difficult, requires properly designed equipment, especially for high pressure–high temperature conditions, and is very costly both in time and resources. Moreover, possible natural gas mixtures under experimental study is very large considering that natural gas composition depends strongly on the origin, age, and depth of the reservoir [29]. Likewise, conditions of interest, especially the high pressure – high temperature conditions found in many new reservoirs that can be explored with current technologies [30], has a remarkable effect on natural gas viscosity, and discard the use of traditional measurement techniques. The analysis of published viscosity data in the open literature shows its scarcity both in the number of studied systems and the experimental conditions (high pressure data are almost absent) [28,31]. Therefore, systematic studies on natural gas viscosity has to be carried out in wide pressure-temperature ranges and as a function of mixture compositions, for selected mixtures representative of key reservoirs. Our group is involved in a multilaboratory international research project in which natural gas viscosity is measured, and other relevant thermophysical properties, using state-of-the-art equipments [31,32]. As a result of our research, we report in this section a detailed analysis of the available experimental methods for measurement of natural gas viscosity.
Rolling ball viscometers measuring principle is based on the travelling time of a metal or glass ball through a known distance to measure the viscosity of the fluid, Figure 3. The ball of known diameter rolls down a tube of known length, at a known inclination, filled with the fluid under study, under isothermal-isobaric conditions.
The viscosity of the fluid is proportional to the ball travelling time, considering that the fluid flow around the ball is laminar. Sage and Lacey [33] proposed corrections to be applied in case of viscosity measurements under turbulent flow.
The working principle of rolling ball viscometers may be summarized in equation (7):
Scheme of a rolling ball viscometer.
Where (b and ( stand for the ball and fluid density, respectively,
The use of rolling ball viscometers for gas measurements is very scarce, and high pressure data are almost absent. Sage and Lacey [33] measured viscosity data for methane and two hydrocarbon gases up to 2900 psi, Bicher and Katz [34] measured the viscosities of methane-propane mixtures up to 5000 psi. The uncertainty of viscosity measurements using rolling ball viscometers it is claimed to be ± 2 % when applied for measurements in the liquid state [35], although no detailed uncertainty analysis is available for gas measurements. Dolan et al [36] carried out gas phase measurements for n-butane using a capillary viscometer and showed large difference with rolling ball viscometer data by Sage et al. [37], who claimed a ± 5 % for their gas phase viscosity measurements.
The working principle of classical capillary viscometers (so-called Rankine viscometers) is based on the introductions of a pellet of mercury into a tube filled with the gas under study, with the mercury pellet completely filling the cross section of the tube. The mercury pellet will reach a steady descending velocity will for any inclination of the tube. The descending pellet will act as a moving piston, which will force the gas through an adjacent capillary, leading to a constant pressure difference across the fine capillary. Gas viscosity is obtained from the measurement of the mercury pellet falling time between two fixed points. Capillary viscometers have been widely studied for gas measurement because of their operational simplicity and the small amounts of required gas. Heath [38] analyzed the performance of capillary viscometers for gas phase measurements, and Kobayashi [39] carried out a detailed analysis of the application of Hagen-Poiseuille\'s law for gases to the Rankine viscometer. Giddings et al. [40] developed a high-pressure capillary viscometer, which was applied for measurements of methane, propane and their mixtures up to 544.4 atm with a 0.25 % claimed reproducibility. Lee et al. [41] carried out systematic measurements of the viscosity of natural gas mixtures using a capillary viscometer with an estimated accuracy of ±2.00. In a recent work, May et al. [42] obtained reference viscosity data for several gases, including methane, using a modification of capillary viscometer.
The falling body and the capillary tube methods for viscosity measurements require hydrodynamic corrections and approximations for ends, edges, and walls. These applied corrections are not always known, and in most cases are sources of important errors. These corrections are avoided by the use of vibrating wire based viscometers. These apparatus are based on the damping of the vibrations of a wire in the fluid under study. An applied external field disrupts the wire immersed in the fluid, leading to periodic oscillations. In the free-decay mode the damping of the oscillations depends on the viscosity and density of the fluid [43]. This technique can be applied in a straightforward manner to low viscosity fluids, in fact most of the available contemporary natural gas viscosity data have been measured using vibrating-wire based approaches. Tough et al. [44] and Trappeniers [45] were the first to apply vibrating wire devices for the measurement of low viscous fluids and gases at high pressures. Assael et al. [46] carried out viscosity measurements of a natural gas mixture with a claimed uncertainty of ± 1 % up to 15 MPa. Langelandsvik et al. [47] measured viscosity of three natural gas mixtures with a ± 1% estimated uncertainty up to 5.0 MPa. Schley al. [48] measured viscosity of methane and two natural gases up to 29 MPa with a ±0.3 % and ±0.5 % estimated uncertainties for methane and gas mixtures, respectively. Likewise, vibrating-wire viscometers are considered as quasi-primary measurement methods [43].
The experimental setup for these instruments is very similar to that for rolling body viscometer with the exception that the ball is replaced with a piston. These equipments have been widely for measuring liquid viscosity but measurements for low viscous gases are scarce. In most cases the viscometer arrangement is vertical, which is a serious limitation for gas measurements considering the very short travelling times. Heidaryan et al. [49] used a falling body viscometer for measuring methane viscosity up to 140 MPa.
A modification of traditional falling body viscometers has recently proposed to withdraw the aforementioned disadvantages and to apply this equipment to large pressure temperature ranges. In this equipment a piston is placed inside a cylindrical measuring chamber filled with the fluid (gas or liquid) under study, the piston is driven electromagnetically by two coils located at opposite ends and the time taken by the piston to complete one motion is correlated to the viscosity of the fluid in the measuring chamber by a working equation. A scheme of the equipment installed in our laboratory is showed in Figure 4. The measurement chamber is placed at 45º inclination, and the setup allows measurements from 0.02 to 10000 cp, simply changing the used piston.
Electromagnetic viscosity measuring device [
The main advantage of this equipment is the ability to carry out fast measurements in wide pressure-temperature ranges. Nevertheless, Thomas et al. [50] and Viswanathan [51] reported problems for gas viscosity measurements using electromagnetic viscometers, mainly raising from the poorly defined pressure-temperature dependence of the measurement chamber properties. Therefore, we proposed a new calibration method using this equipment to avoid these problems, which was validated against reference viscosity data, leading ± 0.1 % reproducibility and to ± 2.5 % and ± 4.0 % uncertainties, for pressures lower than 30 MPa and higher than 30 MPa, respectively. Nevertheless, we should remark that the uncertainty values are derived from the uncertainties obtained from the calibration fluids. This is a remarkable problem for viscosity measurements, the use of secondary methods requires the knowledge of highly accurate viscosity data for reference fluids, in wide pressure – temperature ranges, which is not currently available [43]. Nevertheless, the use of electromagnetic based viscometer allow to obtain wide collection of viscosity data for gas mixtures, in wide pressure – temperature ranges, with acceptable accuracy and at moderate costs.
The prediction of natural gas vapor–liquid equilibria is of primary importance for industrial purposes [52]. This property, together with the knowledge of PVT behavior, is required in all the stages of natural gas production / transportation chain. The vapor–liquid equilibria of natural gas mixtures is commonly analyzed using the pressure–temperature projection, so–called phase envelope, Figure 5, in which a curve separating the two–phase (vapor–liquid equilibria) and single–phase (vapor or liquid) regions is plotted.
Phase envelope of a typical natural gas.
In this curve, three points are of remarkable importance:
For reservoir engineering purposes, care must be taken to maintain the gas in single phase conditions because during exploration a pressure depletion may lead to an erroneous determination of reservoir composition (and thus to incorrect field–development designs), because dew point curve is crossed and liquid is formed, and during production liquid drop-out may lead to valuable hydrocarbons left behind in the reservoir [54]. If liquid drop-out appears in the wellbore, it may lead to liquid loading concerns. For custody transfer purposes, the inaccuracy in the knowledge of phase envelopes may lead to contractual disputes rising from the contract sales gas dew point specifications between the company that sales the gas and the purchaser. For transportation through pipelines [29], it is essential to maintain the fluid pressure above the cricondenbar to protect the compressors which may be damaged by the presence of liquid drops [55]. Moreover, the sizing of the compressors depends on the value of the predicted cricondenbar, and thus, inaccuracy in the knowledge of this value may lead to an oversizing of the expensive compressors (if the real value is lower than the predicted ones) or to a two–phase flow (if the real value is above the predicted one) along the pipelines. Hence, accurate knowledge of phase envelopes allows reducing the design margins, to optimize the pipelines capacity, and thus, to improve the economic viability of new pipelines projects [56].
Therefore phase envelopes must be known before production / transportation operations are designed for any new gas–field. The most accurate and reliable way to obtain the phase envelope for any natural gas mixtures is its determination through experimental measurements [12] Nevertheless, these measurements require state–of–the–art apparatus, which are very costly, both in time and resources, and, considering that the composition, and thus properties, of natural gases can vary widely depending upon the reservoir from which the fluid comes, it is almost impossible carry out measurements for all the possible mixtures over the wide temperature and pressure ranges required. Thus, the common way to obtain phase envelopes for design purposes in the gas industry is through available theoretical models, using gas chromatography determined compositions, and thus, the reliability of the designs stands on the accuracy of the used models. In the natural gas industry, equations of state (EOS) are the common choice for phase equilibria predictions, and cubic EOS are mainly used because of their simplicity. Multiparametric EOS developed in the last years, such as AGA8–DC92 [4], which are used with high accuracy for density predictions are not applicable for phase equilibrium calculations or for liquid properties, and thus other EOS such as cubic ones or new multiparametric GERG2008 [7] are used to characterize natural gas. Nonetheless, the predictive ability of available models for phase equilibria have to be studied against accurate experimental data to test their reliability, and thus, experimental measurements for selected natural gas mixtures using accurate methods are required [57].
Experimental methods for measurement of vapor-liquid equilibria in high pressure conditions may be classified as
For the analytic method, pressure and temperature are fixed and then phase separation is produced, sampling for each phase under equilibrium is carried out and then composition is determined by chromatographic methods. This technique may carried out using static or dynamic circulation approaches. The experimental results from this type of experimental equipment are usually isothermal or isobaric phase diagrams. Natural gas mixtures usually contain small fractions of heavy components (C6+ fractions), which are difficult to measure accurately through chromatographic methods, and thus, this approach is not very useful for the study of natural gas mixtures.
In the synthetic method a mixture of known composition is prepared and its behavior observed as a function of pressure or temperature. The experimental results from this type of equipment are isopleth phase diagrams. The synthetic method may be subdivided into visual and non-visual.
4.2.2.1. Visual synthetic methods
Chilled mirror dew point meters is the simplest and most widely applied method of hydrocarbon dew point measurement in the gas industry. These instruments have a metallic mirror surface inside a high-pressure sample cell. The instruments are also equipped with a glass viewing port through which operator can observe the mirror surface. Mirror dew point meters normally are used for periodic spot check measurements [59].
The principle of the mirror dew point meter is to observe the very first signs of condensate, Figure 6. Therefore, cooling samples for several pressures allows to build the phase envelope, Figure 7.
Scheme of a chilled mirror equipment for phase envelope measurements.
The main difficulties in making such a measurement lie in the characteristics of hydrocarbon condensates. The natural gas condensates are colorless and have low surface tension. This means that the liquid film that forms as the sample cools through the dew point temperature is almost invisible to operators. At the same time, the decreasing temperature measurement reading must be observed as the mirror temperature drops. To achieve the best sensitivity and repeatability of measurement, the rate of mirror cooling is critical and should be as slow as possible through the region in which the dew point is likely to be found [60]. The subjective nature of such a measurement technique can result in large uncertainty in natural gas dew point measurement [59].
Scheme of experimental procedure for measuring phase envelopes using visual chilled mirror method.
4.2.2.2. Non-visual synthetic methods
The method usually involves a blind
The technique for determining phase loops using isochoric method utilizes the change of the slope of an isochore as it crosses the phase boundary, Figure 8.
It should be remarked that the change of slope does not occur at the cricondentherm, which has a collinear isochore [62]. The apparatus cell volume changes slightly with pressure and temperature, and thus, experimental data require an application of the cell distortion equation to correct the results to truly isochores. In a recent work Acosta et al. [63] developed a new computational method for the analysis of isochoric data to obtain phase envelope experimental data points, reporting that the phase boundary temperatures and pressures could be determined within 0.45% and 0.04%, respectively. Our research group has developed a systematic measurement program on selected natural gas-like mixtures using the isochoric method with the cell design reported in Figure 9 [64-66]. The reported results allowed to analyze the predictive ability of the equations of state commonly used in the gas industry for phase envelope predictions showing large deviations, which justify the need of very accurate experimental data for the analysis and prediction of natural gas phase equilibria.
Method for determine phase envelope from isochoric measurements.
Scheme of isochoric cell design [
Techniques for the measurement of the most relevant thermophysical properties for the characterization of natural gas mixtures are reviewed showing the state-of-the-art, and the weaknesses and strengths of the current methods. Accurate determination of density, viscosity and phase equilibria are extremely important for the natural gas industry, both for technical and economical reasons, for production, processing and transportation purposes. Likewise, exploration and production using non-conventional reservoirs, including high pressure conditions, requires the accurate measurements in wide pressure-temperature ranges. Moreover, current predictive theoretical models using in the gas industry can not be used out of their tested pressure – temperature ranges, and thus, new accurate data are required to check the models performance and / or develop new theoretical predictive approaches. Therefore, this review could help to guide in the selection of the most suitable experimental approach for the determination of the required properties in wide pressure – temperature ranges.
Indonesia is a country that often experiences hydrometereological disasters, including disasters caused by climate change and weather [1]. The National Disaster Management Agency (BNPB) noted that, in the period of 2020, Indonesia has experienced 2,925 natural disasters, starting from Wednesday (1/1/2020) to Tuesday (28/12/2020). According to data compiled by BNPB, the disasters that occurred throughout 2020 were dominated by hydrometeorological natural disasters such as floods, flash floods, landslides, hurricanes, droughts, forest and land fires. Based on the details of hydrometeorological disaster data, flood events have occurred up to 1,065 events throughout 2020. Disasters caused by hurricanes have occurred as many as 873, landslides as many as 572 events. Furthermore, for forest fires there have been 326 incidents, tidal waves and abrasion have occurred 36 events, and droughts have occurred as many as 29 events. For the types of geological and volcanic disasters, there are 16 and 7 events, respectively. There were 370 people who died as a result of the natural disaster, 39 people were missing and 536 people were injured.
East Java, is one of the provinces in Indonesia, which is on the island of Java. This province is located in the west of the province of Bali and in the east of the province of Central Java, Figure 1.
Map of East Java [
East Java has the largest area among 6 provinces on the island of Java (about 407,803 km2), and has the second largest population (40.67 million people). Based on province, West Java province has the largest population in Indonesia in 2020, which is 48.27 million people. Meanwhile, East Java province is bordered by the Java Sea in the north, the Bali Strait in the east, the Indian Ocean in the south, and Central Java Province in the west. Several small islands, namely the islands of Madura, Bawean, Kangean and a number of small islands in the Java Sea (Masalembu) and the Indian Ocean (Sempu Island and Nusa Barung) are also the East Java Region.
Administratively, the total number of Districts and Municipalities in East Java is 38, as seen in Table 1.
No. | Region Name | Capital city | Area |
---|---|---|---|
1 | District Bangkalan | Bangkalan | 1,001.44 kms (2.10%) |
2 | District Banyuwangi | Banyuwangi | 5,782.40 kms (12.10%) |
3 | District Blitar | Kanigoro | 1,336.48 kms (2.80%) |
4 | Bojonegoro | Bojonegoro | 2.198,79 kms (4.60%) |
5 | District Bondowoso | Bondowoso | 1.525,97 kms (3.19%) |
6 | District Gresik | Gresik | 1.191,25 kms (2.49%) |
7 | District Jember | Jember | 3.092,34 kms (6.47%) |
8 | District Jombang | Jombang | 1.115,09 kms (2.33%) |
9 | District Kediri | Ngasem | 1.386,05 kms (2.90%) |
10 | District Lamongan | Lamongan | 1.782,05 kms (3.73) |
11 | District Lumajang | District Lumajang | 1.790,90 kms (3.75%) |
12 | District Madiun | Caruban | 1.037,58 kms (2.17%) |
13 | District Magetan | Magetan | 688.84 kms (1.44%) |
14 | District Malang | Kepanjen | 3,530.65 kms (7.39%) |
15 | District Mojokerto | Mojosari | 717.83 kms (1.50%) |
16 | District Nganjuk | Nganjuk | 1,224.25 kms (2.56%) |
17 | Ngawi | Ngawi | 1,295.98 kms (2.71%) |
18 | District Pacitan | Pacitan | 1,389.92 kms (2.91%) |
19 | District Pamekasan | Pamekasan | 792.24 kms (1.66%) |
20 | District Pasuruan | Bangil | 1,474.02 kms (3.08%) |
21 | District Ponorogo | Ponorogo | 1,305.70 kms (2.73%) |
22 | District Probolingge | Kraksaan | 1,696.21 kms (3.55%) |
23 | District Sampang | Sampang | 1,233.08 kms (2.58%) |
24 | Sidoarjo | Sidoarjo | 634.38 kms (1.33%) |
25 | District Situbondo | Situbondo | 1,669.87 kms (3.49%) |
26 | District Sumenep | Sumenep | 1,998.54 kms (4.18%) |
27 | District Trenggalek | Trenggalek | 1,147.22 kms (2.40%) |
28 | District Tuban | Tuban | 1,834.15 kms (3.84%) |
29 | District Tulungagung | Tulungagung | 1,055.65 kms (2.21%) |
30 | Municipality, Batu | Kota Batu | 136.74 kms (0.29%) |
31 | Municipality, Blitar | Blitar | 32.57 kms (0.07%) |
32 | Municipality, Kediri | Kediri | 63.40 kms (0.13%) |
33 | Municipality, Madiun | Madiun | 33.92 kms (0.07%) |
34 | Municipality, Malang | Malang | 145.28 kms (0.30%) |
35 | Municipality, Mojokerto | Mojokerto | 16.47 kms (0.03%) |
36 | Municipality, Pasuruan | Pasuruan | 35.29 kms (0.07%) |
37 | Municipality, Probolinggo | Probolinggo | 56.67 kms (0.12%) |
38 | Municipality, Surabaya | Surabaya | 350.54 kms (0.73%) |
The district and major cities in East Java.
Cumulatively, based on calculations from the records of the National Disaster Management Agency (BNPB), from 2013 to 2019, in East Java there have been 2676 hydrometeorological disasters. The details are: floods as many as 743 cases, landslides 514 cases, drought 66 cases, forest fires 361 cases, tidal waves 22 cases and strong winds as many as 970 cases. When viewed from a case-by-case approach, it can be seen that every year there is an increase in the number of disasters. Between 2013 and 2014 there were about 233 cases, then increased to 297 cases in 2015, increasing again in 2016 by 404 cases, 2017 around 434 cases, 2018 increasing to 455 cases and increasing rapidly in 2019 with the number of cases amounting to 620 cases. The trend of increasing hydrometeorological disasters in each type of disaster has undergone significant changes. This condition can be checked by conducting media studies, by looking for disasters that occurred in the period 2019 to 2020. Around 50 more local journalists wrote about hydrometeorological disasters, from floods, landslides, forest fires, droughts, tidal waves and droughts in East Java.
The East Java Regional Disaster Management Agency (BPBD) revealed that in 2019 there had been floods covering 15 districts, namely: Madiun, Nganjuk, Ngawi, Magetan, Sidoarjo, Kediri, Bojonegoro, Tuban, Probolinggo, Gresik, Pacitan, Tranggalek, Ponorogo, Lamongan and Blitar. The worst flooding occurred in the Madiun area. The disaster affected 12,495 families from the population of 15 districts in East Java. In 2019, BPBD recorded areas affected by drought and lack of clean water covering 22 districts, 128 sub-districts and 450 villages. Meanwhile for forest and land fires, where East Java has 8 active volcanoes, forest fires occur when entering the peak of the dry season. The mountains are Arjuna, Welirang, Kawi, Kelud, Wilis, Semeru, Bromo, and Ijen. According to the Ministry of Environment and Forestry (KLHK) there were approximately 23,655 hectares of forest area and land burned in 2019.
In 2020, there are several records related to disasters such as strong winds that hit Ponorogo, landslides that occurred in Lumajang and floods that hit Pasuruan, Mojokerto, Jombang, Madiun and Trenggalek. In 2020, according to data from the Ministry of Environment and Forestry, there were around 19,148 hectares of land and forest burned in East Java. Throughout 2020, there were around 31 regions in East Java that experienced drought and lack of clean water. Meanwhile, in early 2021, East Java was faced with floods that hit several areas, the worst occurred in Jember which almost affected 7 sub-districts.
This research was conducted in two places, namely Jawar Hamlet, Srimulyo Village, Malang Regency and Banaran Village, Ponorogo Regency, both of which are in East Java. These two areas have experienced land subsidence and landslides, as well as flash floods.
Jawar Hamlet, Sri Mulyo Village, Dampit Subdistrict, Malang Regency is one of the villages prone to landslides in East Java Province [3], Preliminary Study of Landslide In Sri Mulyo, Malang, Indonesia Using Resistivity Method And Drilling Core Data). On January 24, 2006, there was a landslide in the village which caused 1 house to be destroyed, 14 houses cracked on the walls and foundation. In addition, the landslide also resulted in 3 large landslide areas, and 12 small landslides that cut off access to village roads as deep as 60 cm. The area where the landslide occurred, after being examined geologically, was found to be located above weathered breccia rocks that lay on top of the limestone of the Wonosari Formation. When viewed from the angle of inclination, the landslide area actually has a slope of 120–200 or not too steep. The landslide incident showed that the cause of the landslide was not purely due to the slope, but because the area was located in a gravity fault area, which is thought to have caused the landslide of limestone, which is located at the bottom of the landslide area [4].
The village of Sri Mulyo, Dampit subdistrict (Figure 2) is geographically located at 8.2928 0 SL 112.7991 0 EL. Administratively, Sri Mulyo village in the north is bordered by Bumirejo Village, Ampelgading Sub-District in the east, Sumbermanjing Wetan Sub-District in the west, and Sukodono Village in the south. In general, the soil structure in Sri Mulyo village is podzolic soil, where the topography is plains and mountains with an altitude of 400–790 meters above sea level, and the slope of the slope is less than 40%. The average annual rainfall is 5229 millimeters. The majority of the population is coffee and salak farmers.
Geoelectrical resistivity measurement survey design, Sri Mulyo Village.
The second research area is Banaran village. Banaran village is located in Ponorogo Regency, East Java (Figure 3). Banaran village has a land area of 2827,713 ha divided into four small villages (hamlet), namely Krajan, Gondang Sari, Tangkil, and Sooro. Banaran Village is one of 18 villages in Pulung District. The locations of Banaran village is: In the west it is bordered by Bekiring Village, Pulung Sub-District; in the east bordering the Tambang Village, Pudak Sub-District; In the north it is bordered by Talun Village, Ngebel Sub-District and in the south by Wagir Kidul Village, Pulung Sub-District.
Banaran Village, Ponorogo regency, Indonesia (Google maps, 2018).
One method to analyze a landslide is to use geophysical methods. Geophysical method is a method to determine the subsurface conditions of the earth based on physical parameters. The resistivity method is one of the most widely used geophysical methods in the fields of hydrogeology, disaster mitigation, and archeology [5, 6, 7, 8, 9]. Several previous studies has shown that the resistivity method is effective for knowing the subsurface conditions of landslide-prone areas [4, 10, 11, 12, 13, 14].
It is important to conduct research in the Jawar Hamlet, Sri Mulyo Village, Malang Regency and Banaran Village, Ponorogo Regency so that the area’s vulnerability to landslides is known. This landslide analysis was carried out as one of the disaster mitigation efforts, because the area had experienced landslides in the past. The core drilling method was also carried out to confirm the results of the geoelectrical interpretation, especially for the Jawar hamlet area. The landslide analysis is expected to provide an overview of subsurface conditions supported by Turen and Ponorogo Geological Map, and it can determine the landslide fields as well thickness of landslide potential material at the study site.
The resistivity method basically utilizes the electrical properties of the earth, by interpreting the apparent resistivity parameters of subsurface rocks. This method is an active method, where an electric current is injected into the earth through two current electrodes (C1 and C2) then the resulting potential difference is captured by two potential electrodes (P1 and P2). By considering the geometry factor of the configuration used, it can be calculated the apparent resistivity of the rock below the surface.
In this study, the configuration used is dipole–dipole (Figure 4). Measurements are made by moving the potential electrode in a path with a fixed current electrode. Next, the current electrode is moved at a distance to the next “n”, which is followed by moving the potential electrode along the cross-section. This is done until between C1 and P1 has a distance of “na”, according to the conditions of the surface in the study area.
Dipole–dipole configuration with, “a” spacing between electrodes (m), “
The research in Jawar Hamlet, Sri Mulyo Village was carried out in 2015 which is located at the coordinates of 08018′44,86″ - 08011′05,16” SL and 112049′22,02″- 112041′56,47” WL. There are 5 measurement lines for the resistivity method (Figure 3). Lines 1, 2, and 3 with a track length of 180 meters, 200 meters and 100 meters, respectively, and the spacing between electrodes is 10 meters. Lines 1 to 3 are measured from Southeast to Southwest. Line 4 with a track length of 200 meters with an electrode spacing of 10 meters while line 5 with a line length of 300 meters and an electrode spacing of 15 meters. Lines 4 and 5 are measured from West to East.
In this study, drilling points were also carried out. This drilling point is carried out in the red and yellow lines. This core extraction is used as a sample for laboratory tests in determining soil characteristics. Drilling was carried out at two points, namely point 1 located on the 60 meter track line 1 and point 2 located 70 meter line length line 2. The results of the drilling were used as supporting data for landslide analysis for the resistivity method. Geoelectric data processing is done with Re2dinv software. Interpretation is carried out by correlation with the Geological Map of the Turen Sheet.
The method used in this research is geo-electric resistivity method, sama seperti yang dilakukan di desa Srimulyo. There are many configurations used in this method. In this research, we used a modified Wenner-Schlumberger configuration (Figure 5) with fixed electrode potential and the current electrode to obtain Vertical Electrical Sounding (VES). To obtain the lateral direction variation, the VES through interpolation dots are measured. This configuration is the right choice if the desired target is the VES with optimal field effectiveness and reduction accumulation error. Measurements were made at 12 points. The selection of this measurement point is based on the fact that the area is still relatively flat and the results of the interpretation can be correlated from one location to another.
Distribution of geo-electric resistivity measurement points.
Based on the results of resistivity data processing and information on the Turen Sheet Geological Map, it can be seen that Jawar Hamlet, Dampit Subdistrict is composed of three rock layers. The lithology of the local area is composed of clay (9,28–85,8
2D cross section of resistivity line 1.
Correlation of 2D cross-sectional resistivity lines 1, 2 and 3 respectively.
Figure 7 shows the presence of clay dominance on the three parallel lines. It is seen that clay predominates to a depth of about 10 meters below the ground surface. This will result in the weight of the soil during the rain will be even greater, due to the infiltration of rainwater into the soil which does not easily come out, due to the very low permeability of the clay. As a result, the boundary between clay and tuff will become increasingly slippery. If this continues for a long time, and if the slope is not able to withstand a large load, there will be a movement of soil down the slope which is commonly referred to as a landslide. The potential for landslides is also higher because the vegetation above the surface of the research site is in the form of seasonal plants (coffee), whose roots are not too deep. This type of plant (coffee), has roots that are not strong enough to bind soil grains.
Figures 8 and 9 show the correlation between the resistivity data and the drilling data. Drilling was carried out on two measurement lines, namely line 1 and line 2 with a depth of 8 meters, which indicates that up to a depth of 8 meters the soil type at the study site was predominantly clay. This, in accordance with the interpretation of resistivity data from the five measurement lines, indicates that to a depth of about 10 meters, the study site is dominated by clay. The correlation of the five measurement lines shows that the avalanche direction is from Northwest to Southeast this is due to the difference in height between lines 4 and 5. When viewed from the results of the study, that the landslide area is relatively flat and the research location is relatively not steep, then the type of landslide in the research location is likely to be a creep type. This type of avalanche is a type that moves slowly down the slope.
Correlation of 2D resistivity and drilling points.
Soil sample test results (a) line 1 and (b) line 2.
Based on the correlation of all data, the data shows that the potential for landslides in the research location has a high level of vulnerability. This is because the thickness of the clay has exceeded 5 meters with a high average annual rainfall of 5299 mm/year, so this will increase the weight of the soil when it rains. In addition, the carrying capacity of plant vegetation is inadequate at the study site, causing settlements to be unsafe from landslide hazards. The results of this study may be one of the considerations of the local government in disaster mitigation at the research location so as to minimize casualties and losses due to landslides.
The results of data processing show that the subsurface conditions at the research site are divided into four constituent rocks, namely; clay (0–100 Ω.m,) tuff (100–1000 Ω.m), volcanic breccia (1000–3000 Ω.m), and andesitic lava (>3000 Ω.m). The depiction of the interpolation results for several depths can be seen in Figure 10. From the analysis results, the subsurface rock at the study site is dominated by clay. The further down, it was detected that the clay became more dominant. This indicates that the landslide material at the study site is very thick.
Contour resistivity at 5 meters depth.
If the correlation is made for inline points, the following results (Figure 11) will be obtained:
Correlation of lithology of measuring points 11, 06, and 03 (from top to bottom).
The results of data processing from this resistivity method indicate that the landslide field is located at a depth of 8 to 35 meters. Tuff is indicated as a landslide field. Interpretation of resistivity data for lithological correlation shows that the upper part of the landslide area is dominated by rocks with low resistivity (conductive) and quite thick (5–35 m) which is indicated as clay. Clay is a type of rock that has very small permeability, which is 10−7 cm/s. In addition, the research location is a steep slope. From the interpretation of the lithological correlation, the estimated slope of the location is ≥400, and the rainfall was quite high at that time, namely 18.95 mm per day. The length of the rainy month is nine months.
The presence of clay with a thickness of more than 5 meters on steep slopes with high rainfall, will cause greater soil weight, especially when rainwater seeps into the soil. When it is found that the bottom layer is clay, the soil will be saturated with water and can no longer come out, because clay is almost impermeable. In addition, the soil which is dominated by clay will be very prone to landslides, because it is soft and slippery when it rains and cracks when it is hot. As a result, if it rains, the steep slope will accelerate the movement of the soil down the slope, which is known as a landslide. In addition, the use of land in the form of settlements and plantations of seasonal crops, such as ginger, spices and so on, makes plant roots not strong enough to withstand soil movement, and not strong enough to absorb rainwater. So, in the end there was a landslide.
The results of this study in Jawar Hamlet, Sri Mulyo Village indicate that the resistivity method can provide a good picture for investigations in locations that have the potential for landslides. The results of the correlation of resistivity data with drilling show that the research location is dominated by clay to a depth of about 10 meters. The level of vulnerability to landslides in Jawar Hamlet, Sri Mulyo Village is high. The results of the investigation of the location’s vulnerability to landslides are expected to be one of the references for the local government in efforts to mitigate landslides. One of the ways to do this is by replacing annual plants to strengthen the binding of the soil grains.
In addition, based on the interpretation of resistivity data, tuff and clay are indicated as slip planes, which are found at depths ranging from 8 meters to 35 meters. The landslide material is the part above the slip plane, which is dominated by clay with a thickness of 5–35 meters. Banaran Village, Ponorogo Regency is an area that is very prone to landslides, based on a landslide-prone area score. Parameters that actively support the occurrence of landslides at the study site are the presence of slip fields, steep slopes, high rainfall and inappropriate land use. Therefore, residents who live in the area are highly expected to be aware of landslides, which can occur at any time, especially during the rainy season. The level of vulnerability to landslides in the Banaran area is relatively high, so it is necessary to relocate residents’ settlements around the Banaran area.
Thanks to Geophysics Laboratory, Physics Department, Brawijaya University in supporting the equipment. The research was funded by Brawijaya University.
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Various technical variants of this test can detect antigen (native or foreign) or antibody, determine the intensity of the immune response whether pathological or not; the type of induced immune response as well as the innate immunity potential; and much more. These capabilities, as well as the high sensitivity and robustness of the test and a small price, make it possible to quickly and reliably diagnose diseases in most laboratories. Besides, ELISA is a test that is also used in veterinary medicine, toxicology, allergology, food industry, etc. Despite the fact that it has existed for almost 50 years, different ELISA tests with different technical solutions are still being developed, which improves and expands the application of the this exceptional test. The aim of this chapter is to empower the rider to optimize, standardize and validate an enzyme linked immunosorbent assay.",book:{id:"9850",slug:"norovirus",title:"Norovirus",fullTitle:"Norovirus"},signatures:"Rajna Minic and Irena Zivkovic",authors:[{id:"325806",title:"Ph.D.",name:"Irena",middleName:null,surname:"Zivkovic",slug:"irena-zivkovic",fullName:"Irena Zivkovic"},{id:"325839",title:"Dr.",name:"Rajna",middleName:null,surname:"Minic",slug:"rajna-minic",fullName:"Rajna Minic"}]},{id:"56750",title:"Laboratory Approach to Anemia",slug:"laboratory-approach-to-anemia",totalDownloads:6255,totalCrossrefCites:2,totalDimensionsCites:4,abstract:"Anemia is a major cause of morbidity and mortality worldwide and can be defined as a decreased quantity of circulating red blood cells (RBCs). The epidemiological studies suggested that one-third of the world’s population is affected with anemia. Anemia is not a disease, but it is instead the sign of an underlying basic pathological process. However, the sign may function as a compass in the search for the cause. Therefore, the prediagnosis revealed by thorough investigation of this sign should be supported by laboratory parameters according to the underlying pathological process. We expect that this review will provide guidance to clinicians with findings and laboratory tests that can be followed from the initial stage in the anemia search.",book:{id:"5942",slug:"current-topics-in-anemia",title:"Current Topics in Anemia",fullTitle:"Current Topics in Anemia"},signatures:"Ebru Dündar Yenilmez and Abdullah Tuli",authors:[{id:"183998",title:"Ph.D.",name:"Ebru",middleName:null,surname:"Dündar Yenilmez",slug:"ebru-dundar-yenilmez",fullName:"Ebru Dündar Yenilmez"},{id:"209103",title:"Prof.",name:"Abdullah",middleName:null,surname:"Tuli",slug:"abdullah-tuli",fullName:"Abdullah Tuli"}]},{id:"33133",title:"Waist Circumference in Children and Adolescents from Different Ethnicities",slug:"waist-circumference-in-children-and-adolescents-from-different-ethnicities",totalDownloads:8023,totalCrossrefCites:4,totalDimensionsCites:7,abstract:null,book:{id:"642",slug:"childhood-obesity",title:"Childhood Obesity",fullTitle:"Childhood Obesity"},signatures:"Peter Schwandt and Gerda-Maria Haas",authors:[{id:"29867",title:"Prof.",name:"Peter",middleName:null,surname:"Schwandt",slug:"peter-schwandt",fullName:"Peter Schwandt"}]},{id:"54411",title:"Isolation and Characterization of Escherichia coli from Animals, Humans, and Environment",slug:"isolation-and-characterization-of-i-escherichia-coli-i-from-animals-humans-and-environment",totalDownloads:6182,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"Working on a diverse species of bacteria that have hundreds of pathotypes representing hundreds of strains and many closely related family members is a challenge. Appropriate research design is required not only to achieve valid desired outcome but also to minimize the use of resources, including time to outcome and intervention. This chapter outlines basics of Escherichia coli isolation and characterization strategies that can assist in research designing that matches the set objectives. Types of samples to be collected, collection and storage strategies, and processing of samples are described. Different approaches to isolation, confirmation and concentration of various E. coli strains are summarized in this chapter. Characterization and typing of E. coli isolates by biochemical, serological, and molecular methods have been explained so that an appropriate choice is made to suite a specific E. coli strain/pathotype. Some clues on sample and isolate preservation for future use are outlined, and general precautions regarding E. coli handling are also presented to the researcher to avoid improper planning and execution of E. coli-related research. Given different options, the best E. coli research design, however, should try as much as possible to shorten the length of time to outcomes.",book:{id:"5493",slug:"-i-escherichia-coli-i-recent-advances-on-physiology-pathogenesis-and-biotechnological-applications",title:"Escherichia coli",fullTitle:"Escherichia coli - Recent Advances on Physiology, Pathogenesis and Biotechnological Applications"},signatures:"Athumani Msalale Lupindu",authors:[{id:"185959",title:"Dr.",name:"Athumani",middleName:"Msalale",surname:"Lupindu",slug:"athumani-lupindu",fullName:"Athumani Lupindu"}]},{id:"53085",title:"Malaria in Pregnancy",slug:"malaria-in-pregnancy",totalDownloads:3220,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Malaria infection during pregnancy is an important public health problem with substantial risks to both the mother and foetus. Pregnant women are the most vulnerable group of malaria‐associated morbidity and mortality. A pregnant woman has an increased risk (up to four times) of getting malaria and twice the chances of dying from malaria, compared to a non‐pregnant adult, becuase the immune system is partially suppressed during pregnancy. Malaria in pregnancy not only affects the mother but also has a dangerous sequel for the developing foetus, resulting in premature delivery or intrauterine growth retardation. Diagnosis of malaria in pregnancy remains a challenge due to the low parasite density and placental sequestration of Plasmodium falciparum. Thus, there is an urgent need for new diagnostic methods to detect malarial parasites in the pregnant women. Though antimalarial drugs are available, which can be safely given in the pregnancy, increasing drug resistance of malarial parasite may pose a big problem in the future. In this chapter, we review the burden of pregnancy‐associated malaria (PAM), its pathogenesis, diagnostic issues during pregnancy and recent guidelines for chemoprophylaxsis and treatment.",book:{id:"5270",slug:"current-topics-in-malaria",title:"Current Topics in Malaria",fullTitle:"Current Topics in Malaria"},signatures:"Kapil Goyal, Alka Sehgal, Chander S. 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Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. 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Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. 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He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. 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The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"117248",title:"Dr.",name:"Andrew",middleName:null,surname:"Macnab",slug:"andrew-macnab",fullName:"Andrew Macnab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"322007",title:"Dr.",name:"Maria Elizbeth",middleName:null,surname:"Alvarez-Sánchez",slug:"maria-elizbeth-alvarez-sanchez",fullName:"Maria Elizbeth Alvarez-Sánchez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",country:{name:"Mexico"}}},{id:"337443",title:"Dr.",name:"Juan",middleName:null,surname:"A. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",slug:"attilio-rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",slug:"yanfei-(jacob)-qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},onlineFirstChapters:{paginationCount:18,paginationItems:[{id:"82875",title:"Lipidomics as a Tool in the Diagnosis and Clinical Therapy",doi:"10.5772/intechopen.105857",signatures:"María Elizbeth Alvarez Sánchez, Erick Nolasco Ontiveros, Rodrigo Arreola, Adriana Montserrat Espinosa González, Ana María García Bores, Roberto Eduardo López Urrutia, Ignacio Peñalosa Castro, María del Socorro Sánchez Correa and Edgar Antonio Estrella Parra",slug:"lipidomics-as-a-tool-in-the-diagnosis-and-clinical-therapy",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - 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We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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