These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
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This collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
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To celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
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Initially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
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These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\n
This collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\n
To celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"8008",leadTitle:null,fullTitle:"Antioxidants",title:"Antioxidants",subtitle:null,reviewType:"peer-reviewed",abstract:"Antioxidants are substances that can prevent or slow damage to living cells caused by free radicals, which are unstable molecules the body produces as a reaction to environmental and other pressures. Sometimes called “free-radical scavengers,” free radicals can cause mutation in different biological compounds such as protein, nucleic acids, and lipids, which lead to various diseases (cancer, cardiovascular disease, aging, etc.). Healthy foods are considered a main source of antioxidant compounds and from the beginning of a person’s life, a strong relationship is seen between antioxidant compounds and the prevention of certain diseases, such as types of inflammations, cardiovascular diseases, and different kinds of cancers. It is thus of great importance that new data relating to antioxidants and their biological activity be collected and that antioxidant modes of action be illustrated.Experts from around the world contributed to the current book, discussing antioxidant sources, modes of action, and their relation to human diseases. Twenty-five chapters are presented in two sections: Antioxidants: Sources and Modes of Action and Antioxidants Compounds and Diseases.",isbn:"978-1-78923-920-1",printIsbn:"978-1-78923-919-5",pdfIsbn:"978-1-83962-725-5",doi:"10.5772/intechopen.77838",price:139,priceEur:155,priceUsd:179,slug:"antioxidants",numberOfPages:418,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"76361b4061e830906267933c1c670027",bookSignature:"Emad Shalaby",publishedDate:"November 6th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/8008.jpg",numberOfDownloads:32837,numberOfWosCitations:170,numberOfCrossrefCitations:134,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:296,numberOfDimensionsCitationsByBook:2,hasAltmetrics:1,numberOfTotalCitations:600,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 5th 2018",dateEndSecondStepPublish:"September 26th 2018",dateEndThirdStepPublish:"November 25th 2018",dateEndFourthStepPublish:"February 13th 2019",dateEndFifthStepPublish:"April 14th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"63600",title:"Prof.",name:"Emad",middleName:null,surname:"Shalaby",slug:"emad-shalaby",fullName:"Emad Shalaby",profilePictureURL:"https://mts.intechopen.com/storage/users/63600/images/system/63600.png",biography:"Dr. Emad Shalaby is a professor of biochemistry on the Biochemistry Department Faculty of Agriculture, Cairo University. He\nreceived a short-term scholarship to carry out his post-doctoral\nstudies abroad, from Japan International Cooperation Agency\n(JICA), in coordination with the Egyptian government. Dr.\nShalaby speaks fluent English and his native Arabic. He has 77\ninternationally published research papers, has attended 15 international conferences, and has contributed to 18 international books and chapters.\nDr. Shalaby works as a reviewer on over one hundred international journals and is\non the editorial board of more than twenty-five international journals. He is a member of seven international specialized scientific societies, besides his local one, and\nhe has won seven prizes.",institutionString:"Cairo University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1182",title:"Clinical Pharmacology",slug:"clinical-pharmacology"}],chapters:[{id:"65225",title:"Antioxidant Categories and Mode of Action",doi:"10.5772/intechopen.83544",slug:"antioxidant-categories-and-mode-of-action",totalDownloads:2261,totalCrossrefCites:6,totalDimensionsCites:19,hasAltmetrics:0,abstract:"Oxidative stress has received a considerable scientific attention as a mediator in the etiology of many human diseases. Oxidative stress is the result of an imbalance between free radicals and antioxidants. Cells can be damaged by free radicals that are considered to play a main role in the aging process and diseases development. Antioxidants are the first line of defense against the detrimental effects of free radical damage, and it is essential to maintain optimal health via different mechanisms of action. Types of antioxidants range from those generated endogenously by the body cells, to exogenous agents such as dietary supplements. Antioxidant insufficiency can be developed as a result of decreased antioxidant intake, synthesis of endogenous enzymes, or increased antioxidant utilization. To maintain optimal body function, antioxidant supplementation has become an increasingly popular practice through improving free radical protection. In this chapter, we first elucidate the oxidative stress, and then define the antioxidant and its categories. Finally, introduce the antioxidants mode of actions for cell protection from free radicals.",signatures:"Manal Azat Aziz, Abdulkareem Shehab Diab and Abeer Abdulrazak Mohammed",downloadPdfUrl:"/chapter/pdf-download/65225",previewPdfUrl:"/chapter/pdf-preview/65225",authors:[{id:"276717",title:"Associate Prof.",name:"Manal",surname:"Azat Aziz",slug:"manal-azat-aziz",fullName:"Manal Azat Aziz"},{id:"286369",title:"Dr.",name:"Abdulkareem",surname:"Shehab Diab",slug:"abdulkareem-shehab-diab",fullName:"Abdulkareem Shehab Diab"},{id:"312155",title:"Dr.",name:"Abeer Abdulrazak",surname:"Mohammed",slug:"abeer-abdulrazak-mohammed",fullName:"Abeer Abdulrazak Mohammed"}],corrections:null},{id:"66259",title:"Antioxidant Compounds and Their Antioxidant Mechanism",doi:"10.5772/intechopen.85270",slug:"antioxidant-compounds-and-their-antioxidant-mechanism",totalDownloads:7489,totalCrossrefCites:53,totalDimensionsCites:135,hasAltmetrics:1,abstract:"An antioxidant is a substance that at low concentrations delays or prevents oxidation of a substrate. Antioxidant compounds act through several chemical mechanisms: hydrogen atom transfer (HAT), single electron transfer (SET), and the ability to chelate transition metals. The importance of antioxidant mechanisms is to understand the biological meaning of antioxidants, their possible uses, their production by organic synthesis or biotechnological methods, or for the standardization of the determination of antioxidant activity. In general, antioxidant molecules can react either by multiple mechanisms or by a predominant mechanism. The chemical structure of the antioxidant substance allows understanding of the antioxidant reaction mechanism. This chapter reviews the in vitro antioxidant reaction mechanisms of organic compounds polyphenols, carotenoids, and vitamins C against free radicals (FR) and prooxidant compounds under diverse conditions, as well as the most commonly used methods to evaluate the antioxidant activity of these compounds according to the mechanism involved in the reaction with free radicals and the methods of in vitro antioxidant evaluation that are used frequently depending on the reaction mechanism of the antioxidant.",signatures:"Norma Francenia Santos-Sánchez, Raúl Salas-Coronado, Claudia Villanueva-Cañongo and Beatriz Hernández-Carlos",downloadPdfUrl:"/chapter/pdf-download/66259",previewPdfUrl:"/chapter/pdf-preview/66259",authors:[{id:"143354",title:"Dr.",name:"Raúl",surname:"Salas-Coronado",slug:"raul-salas-coronado",fullName:"Raúl Salas-Coronado"},{id:"148546",title:"Dr.",name:"Norma Francenia",surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez"},{id:"193718",title:"Dr.",name:"Beatriz",surname:"Hernández-Carlos",slug:"beatriz-hernandez-carlos",fullName:"Beatriz Hernández-Carlos"},{id:"278133",title:"Dr.",name:"Claudia",surname:"Villanueva-Cañongo",slug:"claudia-villanueva-canongo",fullName:"Claudia Villanueva-Cañongo"}],corrections:null},{id:"65142",title:"Effect of the Ozonization Degree of Emu Oil over Healing: An Emerging Oxidation Treatment",doi:"10.5772/intechopen.83383",slug:"effect-of-the-ozonization-degree-of-emu-oil-over-healing-an-emerging-oxidation-treatment",totalDownloads:1214,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter deals with the ozonization process of the emu oil, the objective of this study was to quantitatively determine the peroxide value (PV) to measure the degree of ozonation, the peroxide value measures the number of peroxide groups in the ozonized oil. The ozone oxidizes the unsaturated chemical functions present in the oil giving a high cure rate for epidermal wounds. The healing process is not completely understood and there are different approaches, therefore, it was determined qualitatively if it has healing and inflammation properties, but the results of our studies have shown that the length and width of the wounds were healing quickly thanks to the peroxidation rate of the oils. In addition, both tests were correlated to obtain a greater appreciation of their functions, the mechanism involves a decrease in the inflammation of the wounds and stimulates the process of scar formation.",signatures:"Daniel Martin Márquez López, Tomás A. Fregoso-Aguilar, Jorge A. Mendoza-Pérez and Sergio O. Flores-Valle",downloadPdfUrl:"/chapter/pdf-download/65142",previewPdfUrl:"/chapter/pdf-preview/65142",authors:[{id:"154732",title:"Dr.",name:"Jorge A.",surname:"Mendoza-Pérez",slug:"jorge-a.-mendoza-perez",fullName:"Jorge A. Mendoza-Pérez"},{id:"154908",title:"Dr.",name:"Tomás A.",surname:"Fregoso-Aguilar",slug:"tomas-a.-fregoso-aguilar",fullName:"Tomás A. Fregoso-Aguilar"},{id:"273582",title:"Dr.",name:"Sergio O.",surname:"Flores-Valle",slug:"sergio-o.-flores-valle",fullName:"Sergio O. Flores-Valle"},{id:"277367",title:"M.Sc.",name:"Daniel",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López"}],corrections:null},{id:"66234",title:"Antioxidant Compounds from Agro-Industrial Residue",doi:"10.5772/intechopen.85184",slug:"antioxidant-compounds-from-agro-industrial-residue",totalDownloads:1239,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:1,abstract:"Agro-industrial residues are a potential source of antioxidant compounds, which in general are phenolic compounds with a large chemical variability. The structure and the complexity of the phenolic compounds (polyphenols) determine their antioxidant capacity, pretreatments, and extraction methods. This chapter gives an overview of the chemical complexity of the phenolic compounds found in extractable and non-extractable fractions of agro-industrial residues, and representative compounds that are present in such residues are shown. Moreover, extraction methods described in this review showed the use of nonconventional technologies and chemical, enzymatic, or thermic treatments, useful to transform non-extractable polyphenols (NEP) to extractable polyphenol (EP) and then apply the EP extraction methods and recover antioxidants.",signatures:"Beatriz Hernández-Carlos, Norma Francenia Santos-Sánchez, Raúl Salas-Coronado, Claudia Villanueva-Cañongo and Paula Cecilia Guadarrama-Mendoza",downloadPdfUrl:"/chapter/pdf-download/66234",previewPdfUrl:"/chapter/pdf-preview/66234",authors:[{id:"148546",title:"Dr.",name:"Norma Francenia",surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez"},{id:"193718",title:"Dr.",name:"Beatriz",surname:"Hernández-Carlos",slug:"beatriz-hernandez-carlos",fullName:"Beatriz Hernández-Carlos"},{id:"234670",title:"Dr.",name:"Raúl",surname:"Salas-Coronado",slug:"raul-salas-coronado",fullName:"Raúl Salas-Coronado"},{id:"242658",title:"Dr.",name:"Claudia",surname:"Villanueva-Cañongo",slug:"claudia-villanueva-canongo",fullName:"Claudia Villanueva-Cañongo"},{id:"278157",title:"Dr.",name:"Paula Cecilia",surname:"Guadarrama-Mendoza",slug:"paula-cecilia-guadarrama-mendoza",fullName:"Paula Cecilia Guadarrama-Mendoza"}],corrections:null},{id:"65851",title:"The Bioaccessible Reducing Capacity of Buckwheat-Enhanced Wheat Breads Estimated by Electrochemical Method",doi:"10.5772/intechopen.84716",slug:"the-bioaccessible-reducing-capacity-of-buckwheat-enhanced-wheat-breads-estimated-by-electrochemical-",totalDownloads:822,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The application of cyclic voltammetry (CV) technique for the determination of bioaccessible reducing capacity of buckwheat-enhanced white wheat breads (BEWWBs) and buckwheat-enhanced dark wheat breads (BEDWBs) was addressed. Buckwheat flour (BF) or flour from roasted buckwheat groats (BFR) were used to substitute white (WWF) or dark wheat flour (DWF) at 10, 20, 30, and 50% w/w on total flour basis in bread formula. The study showed that substitution of 10, 20, 30, and 50% of WWF or DWF by BF or BFR in bread formula resulted in almost linear increase of the reducing capacity of BEWWBs and BEDWBs. After digestion of BEWWBs, the bioaccessible reducing capacity was up to fivefold higher than the reducing capacity of the corresponding undigested breads, and in all cases was also higher than that noted for a soluble fraction of the digestible portion of white wheat bread (WWB). In contrast, the bioaccessible reducing capacity of BEDWBs was only up to twofold higher but in all cases did not exceed the value noted for digested dark wheat bread (DWB). Our results indicate that CV methodology is suitable for obtaining rapid electrochemical profile of a bread sample after digestion useful for evaluation of their selected functional properties.",signatures:"Danuta Zielińska",downloadPdfUrl:"/chapter/pdf-download/65851",previewPdfUrl:"/chapter/pdf-preview/65851",authors:[{id:"191296",title:"Dr.",name:"Danuta",surname:"Zielińska",slug:"danuta-zielinska",fullName:"Danuta Zielińska"}],corrections:null},{id:"65762",title:"Antioxidants in Date Fruits and the Extent of the Variability of the Total Phenolic Content: Review and Analysis",doi:"10.5772/intechopen.83851",slug:"antioxidants-in-date-fruits-and-the-extent-of-the-variability-of-the-total-phenolic-content-review-a",totalDownloads:1259,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:0,abstract:"The date fruit is economically important agricultural commodity, as well as a staple food in many countries in the Arab world, North Africa, and the Middle East. Recent interest in its nutritional, health, and therapeutic attributes is manifested by the rise in scientific publications. Dates of various cultivars are widely publicized and highly ranked as rich sources of natural antioxidant constituents and antioxidant activity. Such publicity, justified or otherwise, is sometimes accompanied by misconceptions and claims of cultivar- and/or country-wise superiority. This chapter examines these claims using a dataset generated from scientific studies published over the last three decades focusing on the total phenolic (TP) content of three stages of date maturity, with emphasis on the last stage, Tamer. The dataset contains TP values (mg GAE/100 g DM) from 18 countries and 243 cultivars and included 583 entries. It only examines variability of TP values. Statistical analysis indicates a great variability of TP content, both within a particular cultivar and among different cultivars. Claims of cultivar- and country-wise superiority and very high ranking of date antioxidant activity are not substantiated. The chapter also discusses various causes of high variability and calls for a collaboration work to address the issue.",signatures:"Abdulameer Allaith",downloadPdfUrl:"/chapter/pdf-download/65762",previewPdfUrl:"/chapter/pdf-preview/65762",authors:[{id:"277441",title:"Associate Prof.",name:"Abdulameer",surname:"Allaith",slug:"abdulameer-allaith",fullName:"Abdulameer Allaith"}],corrections:null},{id:"65331",title:"Flavonoids and Phenolic Acids as Potential Natural Antioxidants",doi:"10.5772/intechopen.83731",slug:"flavonoids-and-phenolic-acids-as-potential-natural-antioxidants",totalDownloads:2723,totalCrossrefCites:34,totalDimensionsCites:74,hasAltmetrics:0,abstract:"For centuries, aromatic herbs and spices have been added to different foods to improve the flavor and organoleptic properties. The use of aromatic plants and spices in phytotherapy is mostly related to different activities of their essential oils, such as antimicrobial, spasmolytic, carminative, hepatoprotective, antiviral, and anticarcinogenic activities. Furthermore, many studies point to strong antioxidant activities of aromatic plants and their essential oils. Knowing that phenolic compounds are the most responsible for the antioxidant activity, the amount of total phenolic contents and content of flavonoids have also been determined. In order to examine the antioxidant properties of five different extracts of Laurus nobilis L. leaves, various assays which measure free radical scavenging ability were carried out: 1,1-diphenyl-2-picrylhydrazyl, hydroxyl, superoxide anion, nitric oxide and hydroxyl radical scavenger capacity test, and lipid peroxidation assay. In all of the tests, only the EtOAc extract showed a potent antioxidant effect.",signatures:"Biljana Kaurinovic and Djendji Vastag",downloadPdfUrl:"/chapter/pdf-download/65331",previewPdfUrl:"/chapter/pdf-preview/65331",authors:[{id:"142369",title:"Prof.",name:"Biljana",surname:"Kaurinovic",slug:"biljana-kaurinovic",fullName:"Biljana Kaurinovic"},{id:"286918",title:"Prof.",name:"Djendji",surname:"Vastag",slug:"djendji-vastag",fullName:"Djendji Vastag"}],corrections:null},{id:"66592",title:"The Role of Endogenous Antioxidants in the Treatment of Experimental Arthritis",doi:"10.5772/intechopen.85568",slug:"the-role-of-endogenous-antioxidants-in-the-treatment-of-experimental-arthritis",totalDownloads:966,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:"The pathogenesis of rheumatoid arthritis is poorly understood; however, elevated oxidative stress has been described to be involved. In this chapter, we present experiments with endogenous molecules bearing antioxidative properties. In our studies, we used male Lewis rats, and the arthritis was induced with Mycobacterium butyricum. In the first experiment, we tested coenzyme Q 10 (CoQ 10) in the oral daily dose of 100 mg/kg b.w. Markers of inflammation and total antioxidant status were corrected in the group supplemented. CoQ 10 treatment significantly improved concentrations of the investigated endogenous antioxidants. Further as an important fact, we consider a good bioavailability of used CoQ 10 formulation which was confirmed by increased CoQ concentrations in plasma, tissue, and mitochondria from skeletal muscles. In the second study, we describe the results with hyaluronic acid (HA) administered in oral daily doses of 0.5 mg and 5 mg/kg b.w. and of different molecular weights (0.43, 0.99, and 1.73 MDa). A notable antioxidative effect of HA was assessed: its administration increased the activities of antioxidant enzymes (superoxide dismutase and glutathione peroxidase) in erythrocytes and total antioxidant capacity of plasma and reduced the marker of oxidative damage to lipids—plasmatic lipid hydroperoxides. HA with the highest molecular weight showed the most significant effect.",signatures:"Katarina Bauerova, Jarmila Kucharska, Silvester Ponist, Lukas Slovak, Karol Svik, Vladimir Jakus and Jana Muchova",downloadPdfUrl:"/chapter/pdf-download/66592",previewPdfUrl:"/chapter/pdf-preview/66592",authors:[{id:"39576",title:"Prof.",name:"Vladimir",surname:"Jakus",slug:"vladimir-jakus",fullName:"Vladimir Jakus"},{id:"68832",title:"Dr.",name:"Katarína",surname:"Bauerova",slug:"katarina-bauerova",fullName:"Katarína Bauerova"},{id:"128928",title:"Dr.",name:"Silvester",surname:"Ponist",slug:"silvester-ponist",fullName:"Silvester Ponist"},{id:"289777",title:"Dr.",name:"Jarmila",surname:"Kucharska",slug:"jarmila-kucharska",fullName:"Jarmila Kucharska"},{id:"289778",title:"Dr.",name:"Jana",surname:"Muchova",slug:"jana-muchova",fullName:"Jana Muchova"},{id:"289779",title:"Dr.",name:"Lukas",surname:"Slovak",slug:"lukas-slovak",fullName:"Lukas Slovak"},{id:"289780",title:"Dr.",name:"Karol",surname:"Svik",slug:"karol-svik",fullName:"Karol Svik"}],corrections:null},{id:"66504",title:"Antioxidants as a Double-Edged Sword in the Treatment of Cancer",doi:"10.5772/intechopen.85468",slug:"antioxidants-as-a-double-edged-sword-in-the-treatment-of-cancer",totalDownloads:1626,totalCrossrefCites:13,totalDimensionsCites:18,hasAltmetrics:0,abstract:"Antioxidant compounds are thought to prevent and treat diseases, especially cancer, under any circumstances. For this purpose, nature-based antioxidants nowadays are being commonly used to prevent and treat diseases. Indeed, phenolic compounds found in medicinal plants have opened a new horizon to prevent and treat diseases because of having antioxidant properties. However, some recent studies have reported that antioxidants are not absolute anticancer compounds and certain drugs have been reported to reduce levels of reactive oxygen species (ROS) in the cancer cells, i.e., their main action mechanism. It has been argued that increasing levels of ROS cause an increase in apoptosis rate and therefore can be considered an approach to treat fatal and hard-to-treat cancers. This chapter seeks to partly explain the role of ROS in progression or inhibition of cancer growth in addition to the role of antioxidants in preventing and treating this disease.",signatures:"Majid Asadi-Samani, Najmeh Kaffash Farkhad, Mohammad Reza Mahmoudian-Sani and Hedayatollah Shirzad",downloadPdfUrl:"/chapter/pdf-download/66504",previewPdfUrl:"/chapter/pdf-preview/66504",authors:[{id:"237542",title:"Dr.",name:"Majid",surname:"Asadi-Samani",slug:"majid-asadi-samani",fullName:"Majid Asadi-Samani"},{id:"275475",title:"Dr.",name:"Mohammad",surname:"Reza Mahmoudian-Sani",slug:"mohammad-reza-mahmoudian-sani",fullName:"Mohammad Reza Mahmoudian-Sani"},{id:"295230",title:"Dr.",name:"Najmeh",surname:"Kafash Farkhad",slug:"najmeh-kafash-farkhad",fullName:"Najmeh Kafash Farkhad"},{id:"295231",title:"Dr.",name:"Hedayatollah",surname:"Shirzad",slug:"hedayatollah-shirzad",fullName:"Hedayatollah Shirzad"}],corrections:null},{id:"66207",title:"Antioxidants at Newborns",doi:"10.5772/intechopen.85175",slug:"antioxidants-at-newborns",totalDownloads:947,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Humans possess defense mechanisms against free radicals: enzymatic and non-enzymatic antioxidants. Antioxidant defense is deficient in newborns and can be enhanced by the action of reactive oxygen species, generated by perinatal diseases such as respiratory distress or asphyxia. Prematurity itself will be associated with deficient antioxidant mechanisms, which are primarily enzymatic, but also non-enzymatic. Under oxidative stress conditions, antioxidant defense is overcome and thus, low-molecular weight free iron is released, which is not bound to transferrin and will play a role in Fenton’s reaction, catalyzing lipid peroxidation. The generated ROS will in turn influence antioxidant defense mechanisms, stimulating their synthesis, as an adaptation mechanism of the body in response to the presence of increased ROS levels.",signatures:"Melinda Matyas and Gabriela Zaharie",downloadPdfUrl:"/chapter/pdf-download/66207",previewPdfUrl:"/chapter/pdf-preview/66207",authors:[{id:"219800",title:"Dr.",name:"Melinda",surname:"Matyas",slug:"melinda-matyas",fullName:"Melinda Matyas"},{id:"241399",title:"Dr.",name:"Gabriela",surname:"Zaharie",slug:"gabriela-zaharie",fullName:"Gabriela Zaharie"}],corrections:null},{id:"65974",title:"Prevention of Oxidative Injury Associated with Thrombolysis for Ischemic Stroke",doi:"10.5772/intechopen.84774",slug:"prevention-of-oxidative-injury-associated-with-thrombolysis-for-ischemic-stroke",totalDownloads:945,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Although treatment of ischemic stroke focuses on re-establishing blood flow to the brain (e.g., thrombolysis), delayed reperfusion may be associated with oxidative damage to brain capillary endothelial cells, resulting in cerebral bleeding and death (hemorrhagic transformation). The goal of this study was to define cellular mechanisms responsible for reperfusion injury to brain capillaries, and to provide a rationale for more effective treatment of stroke. Mechanisms of oxidative injury to cerebral capillary endothelial cells were measured in the presence and absence of experimental inhibitors to define the roles of transport and metabolic pathways. In vitro experiments provided evidence that: (1) intracellular calcium is elevated in brain capillary endothelial cells following simulated transient ischemia and reperfusion, due to reverse movement of Na/Ca exchange; (2) a simultaneous increase of calcium and reactive oxygen species (ROS) during re-oxygenation causes mitochondrial dysfunction, thus initiating apoptosis and loss of brain capillary integrity. In vivo studies showed that γ-glutamylcysteine (an antioxidant precursor of glutathione) and the experimental compound KB-R7943 (inhibits reverse movement of Na/Ca exchange) protect brain capillary endothelial cells when co-administered just before reperfusion following transient ischemia. The data indicate that these agents may be useful in preventing oxidative injury associated with thrombolysis for ischemic stroke.",signatures:"Darryl R. Peterson and Ernest J. Sukowski",downloadPdfUrl:"/chapter/pdf-download/65974",previewPdfUrl:"/chapter/pdf-preview/65974",authors:[{id:"229998",title:"Prof.",name:"Darryl R.",surname:"Peterson",slug:"darryl-r.-peterson",fullName:"Darryl R. Peterson"},{id:"230859",title:"Dr.",name:"Ernest J.",surname:"Sukowski",slug:"ernest-j.-sukowski",fullName:"Ernest J. Sukowski"}],corrections:null},{id:"66809",title:"Dietary Antioxidants in the Chemoprevention of Prostate Cancer",doi:"10.5772/intechopen.85770",slug:"dietary-antioxidants-in-the-chemoprevention-of-prostate-cancer",totalDownloads:1048,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:1,abstract:"Prostate cancer is the second most common cancer and the fifth leading cause of cancer death. The incidence of prostate cancer is rising due to increased screening and awareness, and there is epidemiological evidence suggesting an interaction among biological and environmental risk factors in the development and progression of prostate cancer. Vegetables and fruits provide a wide range of antioxidants and phytochemicals that have been demonstrated to have a negative, positive, or no association with prostate cancer risk. Therefore, it is evident that the effect of dietary antioxidants on risk of prostate cancer remains undecided and inconclusive. The main focus of this review was to examine recent and past literature of the chemoprotective properties of five major groups of phytochemicals against prostate cancer development including both in vivo and in vitro findings.",signatures:"Dwayne Tucker, Melisa Anderson, Fabian Miller, Kurt Vaz, Lennox Anderson-Jackson and Donovan McGrowder",downloadPdfUrl:"/chapter/pdf-download/66809",previewPdfUrl:"/chapter/pdf-preview/66809",authors:[{id:"155804",title:"Dr.",name:"Donovan",surname:"McGrowder",slug:"donovan-mcgrowder",fullName:"Donovan McGrowder"},{id:"158092",title:"Mr.",name:"Lennox",surname:"Anderson-Jackson",slug:"lennox-anderson-jackson",fullName:"Lennox Anderson-Jackson"},{id:"280661",title:"Mr.",name:"Dwayne",surname:"Tucker",slug:"dwayne-tucker",fullName:"Dwayne Tucker"},{id:"280662",title:"Ms.",name:"Melisa",surname:"Anderson",slug:"melisa-anderson",fullName:"Melisa Anderson"},{id:"280664",title:"Mr.",name:"Fabian",surname:"Miller",slug:"fabian-miller",fullName:"Fabian Miller"},{id:"291987",title:"Ph.D. Student",name:"Kurt",surname:"Vaz",slug:"kurt-vaz",fullName:"Kurt Vaz"}],corrections:null},{id:"64992",title:"Condensed Benzimidazoles Are a Novel Scaffold for Antioxidant Agents’ Search and Development",doi:"10.5772/intechopen.82817",slug:"condensed-benzimidazoles-are-a-novel-scaffold-for-antioxidant-agents-search-and-development",totalDownloads:853,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Taking into account that the imidazole ring has π-electron redundancy, condensed benzimidazole derivatives have attracted our attention as a promising class for the search for antioxidant substances. Synthesis was carried out, and information on the antioxidant activity of imidazo- and tetrahydropyrimido benzimidazoles was provided. Highly active antioxidant substance enoxifol has been revealed. The data on the synthesis and study of the pharmacodynamic, pharmacokinetic, and toxicological properties of the new antioxidant compound enoxifol are presented. The antioxidant activity of the compound is due to its ability to inactivate superoxide, hydroxyl, and peroxyl radicals, thereby reducing the overall oxidation rate due to a decrease in the total initiation rate. It has been shown that enoxifol has hepatoprotector, antihypoxic, cerebroprotective, nootropic, stress-protective, neuropsychotropic, actoprotective, cardioprotective, antiaggregant, and antithrombogenic properties and is able to prevent rheological disorders in diabetes mellitus.",signatures:"Vadim A. Kosolapov, Alexander А. Spasov, Vera А. Аnisimova and Olga N. Zhukovskaya",downloadPdfUrl:"/chapter/pdf-download/64992",previewPdfUrl:"/chapter/pdf-preview/64992",authors:[{id:"279139",title:"Prof.",name:"Vadim A.",surname:"Kosolapov",slug:"vadim-a.-kosolapov",fullName:"Vadim A. Kosolapov"},{id:"286027",title:"Prof.",name:"Alexander",surname:"Spasov",slug:"alexander-spasov",fullName:"Alexander Spasov"},{id:"286031",title:"Prof.",name:"Olga N.",surname:"Zhukovskaya",slug:"olga-n.-zhukovskaya",fullName:"Olga N. Zhukovskaya"},{id:"286074",title:"Prof.",name:"Vera A.",surname:"Anisimova",slug:"vera-a.-anisimova",fullName:"Vera A. Anisimova"}],corrections:null},{id:"66582",title:"Importance of the Nutrition with Antioxidants in the Treatment of Cancer and Others Damages",doi:"10.5772/intechopen.85469",slug:"importance-of-the-nutrition-with-antioxidants-in-the-treatment-of-cancer-and-others-damages",totalDownloads:856,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The antioxidants are molecules capable of retarding or anticipating the oxidation of other molecules. Epidemiological results have shown that the persons who consume a rich diet of fruits and vegetables present a minor risk of suffering different types of cancer, cardiovascular and neurological diseases, and a minor mortality than the persons who consume few fruits and vegetables. Others studies suggests that the vitamins are antioxidants like can to decrease hurt oxidative in the physiopathology of many chronic diseases and cancer.",signatures:"Eva María Molina Trinidad, Marco Antonio Becerril Flores, José Luis Imbert Palafox and Laura Vargas Servín",downloadPdfUrl:"/chapter/pdf-download/66582",previewPdfUrl:"/chapter/pdf-preview/66582",authors:[{id:"279473",title:"Ph.D.",name:"Eva María",surname:"Molina-Trinidad",slug:"eva-maria-molina-trinidad",fullName:"Eva María Molina-Trinidad"},{id:"290461",title:"Dr.",name:"Marco Antonio",surname:"Becerril Flores",slug:"marco-antonio-becerril-flores",fullName:"Marco Antonio Becerril Flores"},{id:"290462",title:"Dr.",name:"José Luis",surname:"Imbert Palafox",slug:"jose-luis-imbert-palafox",fullName:"José Luis Imbert Palafox"},{id:"290463",title:"Mr.",name:"Laura",surname:"Vargas Servín",slug:"laura-vargas-servin",fullName:"Laura Vargas Servín"}],corrections:null},{id:"66187",title:"Prospects for Using the Natural Antioxidant Compounds in the Obesity Treatment",doi:"10.5772/intechopen.83421",slug:"prospects-for-using-the-natural-antioxidant-compounds-in-the-obesity-treatment",totalDownloads:1003,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Obesity is strongly associated with the insulin resistance development and is an integral pathogenic part of the metabolic syndrome, type 2 diabetes, atherosclerosis, and other comorbid pathologies. It is well known that the obesity causes the disorders in adipose tissue endocrine and metabolic activity, which results in the activation of free radical processes. The administration of natural origin substances with antioxidant properties could be a promising direction for obesity and overweight correction. The objective of the current study was to evaluate the usefulness of natural origin active substances with antioxidant properties’ administration under the obesity and comorbid disorder treatment. This chapter presents the results of experimental studies that proved the usefulness of phenolic compounds from apple food concentrate (Malus domestica L.) and dry bilberry extract (Vaccinium myrtillus L.) application under experimental metabolic syndrome, insulin resistance syndrome, and type 2 diabetes mellitus, which are extremely associated with obesity. It has been found that due to expressive antioxidant activity, these compounds exhibit the high efficiency in carbohydrate metabolism disorders’ correction (in cases of metabolic syndrome and type 2 diabetes), lipids metabolism disorders’ correction (in case of metabolic syndrome), preventing of endothelial dysfunction under experimental insulin resistance, and normalization of antioxidant status in the liver (under experimental type 2 diabetes mellitus).",signatures:"Andriy Zagayko, Tatiana Briukhanova, Dmytro Lytkin, Anna Kravchenko and Victoria Fylymonenko",downloadPdfUrl:"/chapter/pdf-download/66187",previewPdfUrl:"/chapter/pdf-preview/66187",authors:[{id:"155169",title:"Prof.",name:"Andriy",surname:"Zagayko",slug:"andriy-zagayko",fullName:"Andriy Zagayko"},{id:"277619",title:"Dr.",name:"Anna",surname:"Kravchenko",slug:"anna-kravchenko",fullName:"Anna Kravchenko"},{id:"277626",title:"Dr.",name:"Victoria",surname:"Fylymonenko",slug:"victoria-fylymonenko",fullName:"Victoria Fylymonenko"},{id:"277627",title:"Dr.",name:"Tatiana",surname:"Briukhanova",slug:"tatiana-briukhanova",fullName:"Tatiana Briukhanova"},{id:"277628",title:"MSc.",name:"Dmytro",surname:"Lytkin",slug:"dmytro-lytkin",fullName:"Dmytro Lytkin"}],corrections:null},{id:"66039",title:"Potential Antioxidative Effects of Kolaviron on Reproductive Function in Streptozotocin-Induced Diabetic Wistar Rats",doi:"10.5772/intechopen.84822",slug:"potential-antioxidative-effects-of-kolaviron-on-reproductive-function-in-streptozotocin-induced-diab",totalDownloads:1025,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The present study investigated the effects of Kolaviron (KV) on the testicular and epididymal tissue antioxidant status in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of STZ at 50 mg/kg body weight. The antioxidant status was studied by evaluating epididymal and testicular levels of malondialdehyde (MDA), a lipid peroxidation (LPO) marker, and the activities of catalase (CAT) glutathione peroxidase (GPX) and superoxide dismutase (SOD) were also assessed using biochemical techniques. Diabetes induction resulted in testicular and epididymal LPO and adversely affected the activities of antioxidant enzymes evident by a noticeable decrease in enzyme activity in both tissues. The potential antioxidative effects of KV in the testicular and epididymal tissues of STZ-induced diabetes were revealed by its ability to mitigate against LPO and increase the activity of antioxidant defense enzymes in the reproductive tissues studied. KV might potentially be used as an antioxidant as well as antidiabetic treatment; however, further studies are needed.",signatures:"Claudine Manirafasha, Omolola Rebecca Oyenihi, Nicole Lisa Brooks, Stefan S. du Plessis and Yapo Guillaume Aboua",downloadPdfUrl:"/chapter/pdf-download/66039",previewPdfUrl:"/chapter/pdf-preview/66039",authors:[{id:"95656",title:"Dr.",name:"Yapo G.",surname:"Aboua",slug:"yapo-g.-aboua",fullName:"Yapo G. Aboua"},{id:"168702",title:"Prof.",name:"Stefan S.",surname:"Du Plessis",slug:"stefan-s.-du-plessis",fullName:"Stefan S. Du Plessis"},{id:"203689",title:"Dr.",name:"Nicole Lisa",surname:"Brooks",slug:"nicole-lisa-brooks",fullName:"Nicole Lisa Brooks"},{id:"276123",title:"Dr.",name:"Omolola Rebecca",surname:"Oyenihi",slug:"omolola-rebecca-oyenihi",fullName:"Omolola Rebecca Oyenihi"},{id:"276126",title:"Ms.",name:"Claudine",surname:"Manirafasha",slug:"claudine-manirafasha",fullName:"Claudine Manirafasha"}],corrections:null},{id:"65500",title:"Antioxidant and Biological Activity of Cissus sicyoides and Rosmarinus officinalis Extracts",doi:"10.5772/intechopen.83733",slug:"antioxidant-and-biological-activity-of-em-cissus-sicyoides-em-and-em-rosmarinus-officinalis-em-extra",totalDownloads:1135,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"This chapter will describe the antioxidant and biological activity of Cissus sicyoides and Rosmarinus officinalis leaf extracts, which represent an important natural source of antioxidants. These plants contain several bioactive compounds with high antioxidant activity, such as phenolic compounds, which are compounds that prevent or delay oxidative stress, acting as free radical scavengers (FRSs), and thus reduce the onset of cardiovascular disease, cancer, diabetes, epilepsy, stroke, among other diseases. The supercritical fluid extraction (SFE) has been studied to obtain antioxidant compounds from natural sources, without the drawbacks associated with conventional extraction processes, such as the use of organic solvents, which present toxicity and contaminate the extracts, is proposed.",signatures:"Marielba de los Angeles Rodriguez Salazar, Glides Rafael Olivo Urbina, Priscila do Nascimento Bezerra, Vânia Maria Borges Cunha, Marcilene Paiva da Silva, Flávia Cristina Seabra Pires, Ana Paula de Souza e Silva, Sérgio Henrique Brabo de Sousa and Raul Nunes de Carvalho Jr",downloadPdfUrl:"/chapter/pdf-download/65500",previewPdfUrl:"/chapter/pdf-preview/65500",authors:[{id:"192844",title:"Dr.",name:"Raul",surname:"Nunes de Carvalho Jr",slug:"raul-nunes-de-carvalho-jr",fullName:"Raul Nunes de Carvalho Jr"},{id:"195291",title:"MSc.",name:"Marcilene",surname:"Paiva Da Silva",slug:"marcilene-paiva-da-silva",fullName:"Marcilene Paiva Da Silva"},{id:"195292",title:"MSc.",name:"Vânia Maria",surname:"Borges Cunha",slug:"vania-maria-borges-cunha",fullName:"Vânia Maria Borges Cunha"},{id:"241344",title:"MSc.",name:"Priscila do Nascimento",surname:"Bezerra",slug:"priscila-do-nascimento-bezerra",fullName:"Priscila do Nascimento Bezerra"},{id:"242604",title:"MSc.",name:"Glides Rafael Olivo",surname:"Urbina",slug:"glides-rafael-olivo-urbina",fullName:"Glides Rafael Olivo Urbina"},{id:"242605",title:"MSc.",name:"Ana Paula",surname:"de Souza e Silva",slug:"ana-paula-de-souza-e-silva",fullName:"Ana Paula de Souza e Silva"},{id:"270755",title:"MSc.",name:"Flávia Cristina",surname:"Seabra Pires",slug:"flavia-cristina-seabra-pires",fullName:"Flávia Cristina Seabra Pires"},{id:"270756",title:"MSc.",name:"Marielba De Los Angeles",surname:"Rodriguez Salazar",slug:"marielba-de-los-angeles-rodriguez-salazar",fullName:"Marielba De Los Angeles Rodriguez Salazar"},{id:"282408",title:"MSc.",name:"Sérgio Henrique Brabo De",surname:"Sousa",slug:"sergio-henrique-brabo-de-sousa",fullName:"Sérgio Henrique Brabo De Sousa"}],corrections:null},{id:"65496",title:"Increase of Oxidants and Antioxidant Consumption in Patients with Type 2 Diabetes Mellitus in Peritoneal Dialysis",doi:"10.5772/intechopen.82880",slug:"increase-of-oxidants-and-antioxidant-consumption-in-patients-with-type-2-diabetes-mellitus-in-perito",totalDownloads:1074,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Oxidative stress (OS) is implicated as a unifying factor between chronic kidney diseases and cardiovascular diseases. The objective of the study was to compare the oxidant and antioxidant status in patients with PD according to the state of DM. Lipoperoxides (LPO), 8-isoprostanes (8-IP) and nitric oxide (NO) were determined as oxidants and the activity of superoxide dismutase (SOD) and total antioxidant capacity (TAC) as antioxidants in patients with DM and without DM (No-DM). We included 35 patients with DM, 42 No-DM patients and 10 healthy people as a control group (HC). Patients with DM were older (p<0.0001), had higher BMI (p<0.0001), high glucose levels (p<0.0001) and more hypertension (p<0.0001). It was found that LPO levels increased in patients with DM and No-DM vs. HC (p<0.0001). There was a decrease in the levels of 8-IP in DM and No-DM compared to HC (p<0.0001). The levels of NO in patients with DM and No-DM decreased significantly compared to the HC group with 197.97±34.20 μM (p<0.0001). The activity of the SOD enzyme in patients with DM and No-DM was found to be increased compared to the HC group (p<0.0001). The levels of TAC in HC were 2.62±0.17 mM and decreased in patients with DM and No-DM (p<0.0001).",signatures:"Leonardo Pazarín-Villaseñor, Julio Alejandro Gutiérrez-Prieto, Javier Soto-Vargas, Renato Parra-Michel, Andrés García-Sanchez and Alejandra Guillermina Miranda-Diaz",downloadPdfUrl:"/chapter/pdf-download/65496",previewPdfUrl:"/chapter/pdf-preview/65496",authors:[{id:"178033",title:"Dr.",name:"Alejandra Guillermina",surname:"Miranda-Diaz",slug:"alejandra-guillermina-miranda-diaz",fullName:"Alejandra Guillermina Miranda-Diaz"},{id:"202793",title:"Dr.",name:"Leonardo",surname:"Pazarín-Villaseñor",slug:"leonardo-pazarin-villasenor",fullName:"Leonardo Pazarín-Villaseñor"},{id:"222296",title:"Mr.",name:"Andrés",surname:"García-Sánchez",slug:"andres-garcia-sanchez",fullName:"Andrés García-Sánchez"},{id:"281435",title:"Dr.",name:"Julio Alejandro",surname:"Gutiérrez-Prieto",slug:"julio-alejandro-gutierrez-prieto",fullName:"Julio Alejandro Gutiérrez-Prieto"},{id:"281446",title:"Dr.",name:"Javier",surname:"Soto-Vargas",slug:"javier-soto-vargas",fullName:"Javier Soto-Vargas"},{id:"281447",title:"Dr.",name:"Renato",surname:"Parra-Michel",slug:"renato-parra-michel",fullName:"Renato Parra-Michel"}],corrections:null},{id:"66161",title:"Antioxidants: Natural Antibiotics",doi:"10.5772/intechopen.84864",slug:"antioxidants-natural-antibiotics",totalDownloads:1576,totalCrossrefCites:5,totalDimensionsCites:8,hasAltmetrics:0,abstract:"The aim of this current piece of writing is to draw the attention of readers and researchers toward the natural antioxidants that can take the place of synthetic antibiotics to avoid bacterial resistance and gastrotoxicity/nephrotoxicity. Antioxidants such as polyphenols, vitamins, and carotenoids are the organic compounds mainly extracted from natural sources and dominantly involved in boosting the defense system of organisms. The main public health-related issue over the globe is ever-growing bacterial resistance to synthetic antibiotics, which is being continuously reported during the last decade. Further, the pipeline of the development of new synthetic antibacterial agents to replace the resistant antibiotics in clinical set-up is gradually drying up. This scenario originated the concept to revive the interest toward natural antibacterial products due to their chemical diversity, which provide important therapeutic effect and make the microbes unable to copy them for creating resistance. Natural products, especially polyphenols had been seen in antioxidant, antibacterial, anticancer, anti-inflammation, and antiviral activities with encouraging results. In this chapter, we will focus over the role of natural antioxidants as antibacterial agents.",signatures:"Syed Ali Raza Naqvi, Sana Nadeem, Sana Komal, Syed Ali Asad Naqvi, Muhammad Samee Mubarik, Sajid Yaqub Qureshi, Shahzad Ahmad, Ali Abbas, Muhammad Zahid, Naeem-Ul-Haq Khan, Syed Shujat Raza and Nosheen Aslam",downloadPdfUrl:"/chapter/pdf-download/66161",previewPdfUrl:"/chapter/pdf-preview/66161",authors:[{id:"259190",title:"Dr.",name:"Syed Ali Raza",surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi"},{id:"287649",title:"Ms.",name:"Sana",surname:"Nadeem",slug:"sana-nadeem",fullName:"Sana Nadeem"},{id:"287650",title:"Ms.",name:"Sana",surname:"Komal",slug:"sana-komal",fullName:"Sana Komal"},{id:"287652",title:"Dr.",name:"Muhammad Samee",surname:"Mubarik",slug:"muhammad-samee-mubarik",fullName:"Muhammad Samee Mubarik"},{id:"287654",title:"Dr.",name:"Muhammad",surname:"Zahid",slug:"muhammad-zahid",fullName:"Muhammad Zahid"},{id:"287655",title:"Mr.",name:"Ali",surname:"Abbas",slug:"ali-abbas",fullName:"Ali Abbas"},{id:"298090",title:"Dr.",name:"Syed Ali Asad",surname:"Naqvi",slug:"syed-ali-asad-naqvi",fullName:"Syed Ali Asad Naqvi"},{id:"298091",title:"Dr.",name:"Sajid Yaqub",surname:"Qureshi",slug:"sajid-yaqub-qureshi",fullName:"Sajid Yaqub Qureshi"},{id:"298092",title:"Dr.",name:"Naeem-Ul-Haq",surname:"Khan",slug:"naeem-ul-haq-khan",fullName:"Naeem-Ul-Haq Khan"},{id:"298093",title:"Dr.",name:"Nosheen",surname:"Aslam",slug:"nosheen-aslam",fullName:"Nosheen Aslam"},{id:"303158",title:"Dr.",name:"Shahzad",surname:"Ahmad",slug:"shahzad-ahmad",fullName:"Shahzad Ahmad"},{id:"311133",title:"Mr.",name:"Syed Shujat",surname:"Raza",slug:"syed-shujat-raza",fullName:"Syed Shujat Raza"}],corrections:null},{id:"65067",title:"Diseases Related to Types of Free Radicals",doi:"10.5772/intechopen.82879",slug:"diseases-related-to-types-of-free-radicals",totalDownloads:1789,totalCrossrefCites:7,totalDimensionsCites:11,hasAltmetrics:1,abstract:"The free radicals are reactive molecules with electron-rich groups produced during metabolic reactions occurring in the cells. These free radicals are collectively known as reactive oxygen species (ROS) and reactive nitrogen species (RNS). Lipid peroxidation products and protein carbonyls species are under the group of ROS, and nitric oxide and peroxynitrites are under the group of RNS. The malondialdehyde that reacts with LDL-C indirectly induced the risk of atherosclerosis. The protein carbonyls acts as marker of protein oxidation and exerts damage to proteins. The nitric oxide plays an important role in DNA damage, inflammation, proliferation of cancer cells, and dysfunction of apoptosis. The peroxynitrites could induce the process of lipid peroxidation, DNA damage, and may exert chronic damage to all biomolecules. The aim of the present study is that the free radicals may react with biomolecules of the cells and play an important role in the development of chronic disease conditions in the humans.",signatures:"Narendra Maddu",downloadPdfUrl:"/chapter/pdf-download/65067",previewPdfUrl:"/chapter/pdf-preview/65067",authors:[{id:"272889",title:"Dr.",name:"Narendra",surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu"}],corrections:null},{id:"67584",title:"The Effect of Antioxidants on Ischemia-Reperfusion Injury in Flap Surgery",doi:"10.5772/intechopen.85500",slug:"the-effect-of-antioxidants-on-ischemia-reperfusion-injury-in-flap-surgery",totalDownloads:1003,totalCrossrefCites:4,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Flap surgery has wide use in plastic surgery in the closure of tissue defects. In spite of the major advances in plastic surgery in the past years, flap surgery is still associated with significant mortality. Ischemia-reperfusion (I/R) injury, which is a complex injury associated with flap blood flow, is one of the most important causes of flap failure. The main pathophysiology underneath I/R injury is associated with reactive oxygen species, which can be prevented by certain antioxidant applications. Antioxidants have been widely used in flap surgery and I/R injury previously. There have been a lot of articles showing positive effects of antioxidants on I/R injury. In this chapter, we focus the mechanism of I/R injury and how antioxidants can able to diminish the damage, moreover demonstrating the effect of certain antioxidants on I/R injury that has been investigated previously.",signatures:"Mehmet Bozkurt, Melihcan Sezgic, Percin Karakol, Can Uslu and Tevfik Balikci",downloadPdfUrl:"/chapter/pdf-download/67584",previewPdfUrl:"/chapter/pdf-preview/67584",authors:[{id:"277830",title:"Prof.",name:"Mehmet",surname:"Bozkurt",slug:"mehmet-bozkurt",fullName:"Mehmet Bozkurt"},{id:"297745",title:"Dr.",name:"Perçin",surname:"Karakol",slug:"percin-karakol",fullName:"Perçin Karakol"},{id:"297746",title:"Dr.",name:"Melihcan",surname:"Sezgic",slug:"melihcan-sezgic",fullName:"Melihcan Sezgic"},{id:"297747",title:"Dr.",name:"Can",surname:"Uslu",slug:"can-uslu",fullName:"Can Uslu"},{id:"297750",title:"Dr.",name:"Tevfik",surname:"Balikci",slug:"tevfik-balikci",fullName:"Tevfik Balikci"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:{id:"11",series:{id:"10",title:"Physiology",issn:"2631-8261",editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}}}},tags:null},relatedBooks:[{type:"book",id:"6678",title:"Antioxidants in Foods and Its Applications",subtitle:null,isOpenForSubmission:!1,hash:"819eb2d8d2c889ef23affd7fd01e4e98",slug:"antioxidants-in-foods-and-its-applications",bookSignature:"Emad Shalaby and Ghada Mostafa Azzam",coverURL:"https://cdn.intechopen.com/books/images_new/6678.jpg",editedByType:"Edited by",editors:[{id:"63600",title:"Prof.",name:"Emad",surname:"Shalaby",slug:"emad-shalaby",fullName:"Emad Shalaby"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7258",title:"Resveratrol",subtitle:"Adding Life to Years, Not Adding Years to Life",isOpenForSubmission:!1,hash:"b02655d4c4df83b50688fa1a22661d49",slug:"resveratrol-adding-life-to-years-not-adding-years-to-life",bookSignature:"Farid A. 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\r\n\tThe primary aim of this book is to integrate the knowledge of dairy product manufacturing with the chemistry of ingredients, along with the chemistry of several reactions which appear during the preparation of these products. Therefore, understanding the basic composition of milk and the chemistry of various constituents is of utmost importance. This will be the first topic that will be covered in this book, along with the advance and updated knowledge on the ingredients/ milk constituents. Over the years, the processing and manufacturing of several dairy products have witnessed upgraded processing equipment and hence the protocols of manufacturing. We also hope to cover the advanced processing methods for the production of dairy products. \r\n\tFurthermore, during the preparation of high-quality dairy products, several physical, chemical, enzymatic, and microbial transformations take place. We will consciously focus on this interaction of different constituents of milk under different processing conditions for the development of the products.
",isbn:"978-1-83768-093-1",printIsbn:"978-1-83768-092-4",pdfIsbn:"978-1-83768-094-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"420e687768b56ca7b3238d77f63f1302",bookSignature:"Dr. Neelam Upadhyay",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12173.jpg",keywords:"Protein, Fat, Lactose, Carbohydrates, Milk Processing, Milk Products, Milk Constituents, Acid Coagulated, Enzyme Treated, Heat Treated, Dairy Products, Protocols of Manufacturing",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 18th 2022",dateEndSecondStepPublish:"July 19th 2022",dateEndThirdStepPublish:"September 17th 2022",dateEndFourthStepPublish:"December 6th 2022",dateEndFifthStepPublish:"February 4th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"24 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Dr. Upadhyay has received many awards most notable being the Young Woman Scientist Award 2020 from the Agro-Environmental Development Society and the Best Poster Award 2021 from the National Conference on Moringa Food Conclave 2021. She is a dedicated researcher in food and dairy processing and has published many research articles and papers in both national and international journals and publications.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"269538",title:"Dr.",name:"Neelam",middleName:null,surname:"Upadhyay",slug:"neelam-upadhyay",fullName:"Neelam Upadhyay",profilePictureURL:"https://mts.intechopen.com/storage/users/269538/images/system/269538.jpg",biography:"BRIEF BIODATA\n1.\tName in full: Neelam Upadhyay \n2.\tDate & Place of Birth: 29th December, 1987 at Delhi\n3.\tField of specialization: Food Technology\n4.\tPresent Position/ Designation: Scientist- Senior Scale\n5.\tAddress:\t(a)\tOfficial:\tTel. No.:0184-2259258\n\t\t\t\tE-mail: \ticar.neelam@gmail.com; neelam.upadhyay@icar.gov.in \n\t\t\t\tAddress: \tLaboratory No. 146, Dairy Technology Division, ICAR- \n\t\t\t\t\t\tNational Dairy Research Institute, Karnal \n\t\t\t(b)\tResidential: Tel. No.: +91-9255772587\n\tAddress (Permanent): 41-D, MIG DDA Flats, Shivam Enclave, Delhi-110032\n6.\t(a) Academic career and (b) professional attainments\n(a) Examination\tClass/ Percentage\tYear of Passing\tSubjects Taken\tName of University / Board\nXth \t1st/83\n(415/500)\t2003\tMathematics, Social Science, Science, English, Hindi\tK.V., Mumbai (CBSE)\nXIIth\t1st/78.2 \n(391/500)\t2005\tPhysics, Mathematics, Chemistry, Biology, English\tK.V., Delhi (CBSE)\nB.A.Sc. (Hons.)\t1st/83.43 (2044/2450)\n(3rd position)\t2008\tFood Technology\tSRCASW, University of Delhi, Delhi\nM.Sc.\t1st/8.62\n(1st position)\t2010\tFood Science & Technology\tCCS Har. Agri. Uni., Hisar, Haryana\nTitle of Research:\tDevelopment of flavoured whey-soya milk beverage\nMajor Advisor:\tDr. R. S. Dabur (Professor and Head)\nPh.D.\t1st/8.0\n(1st position)\t2014\tDairy Chemistry\tNational Dairy Research Institute, Karnal, Haryana\nTitle of Research: \tDetection of vegetable oil and animal body fat adulteration in ghee using solvent fractionation technique\nMajor Advisor:\tDr. Darshan Lal (Principal Scientist and Ex-Head)\nDistinctions during Academics\nDegree\tDistinctions\nBachelor of Applied Science (Hons.)\ti.\tY.K. Kapoor Memorial Scholarship 2006 by All India Food Processor’s Association \nii.\t3rd position in university\niii.\tReceived highest attendance award\niv.\tReceived trophy for ‘Most Disciplined Student’ for the graduation period 2005-2008\nv.\tCertificate of Honor from Honb’le Mr. Justice K.G. Balakrishnan, Chief Justice of India\nMaster of Science\ti.\t1st position in discipline and 2nd position in college\nii.\tReceived recognition for academic excellence from Jawaharlal Nehru Memorial Fund; \niii.\tQualified GATE\niv.\t2nd in inter-college yoga competition\nv.\tParticipated in various events of All India Youth Festival organized at UAS, Bangalore.\nDoctor of Philosophy\ti.\tReceived Merit Certificate for Academic Excellence in PhD course work\nii.\tReceived Certificate of Appreciation for outstanding work in the field of Dairy Processing during PhD\niii.\tQualified ICAR’s National Eligibility Test in 2010; Qualified the ICAR’s All India Examination, ICAR-SRF (PGS_-2011-2012 for award of ICAR-SRF (PGS) with 2nd rank (both in first attempt) \niv.\tQualified Agricultural Research Service Examination-2013 conducted by Agricultural Scientist Recruitment Board against the single vacancy (for UR) in the discipline of Food Technology\nv.\tStage Management Secretary of student’s council 2010-11\nvi.\tLiterary secretary of Student’s Council 2011-12\nvii.\tCompleted certificate e-course on “Publishing a Journal Manuscript - the Groundwork” directed by Springer in 2013\nviii.\tHave successfully completed certificate e-course – “Peer Review Academy” directed by Springer in 2013\nix.\tReceived a certificate on accomplishment IRIS 4-2 Information Literacy Plagiarism Quiz (on-line) in 2013 developed by Distance Learning Council of Washington, USA \n (b) Position Held\tInstitution \tPeriod of Appointment\tNature of Appointment\nScientist (Food Technology)\tICAR- National Academy of Agricultural Research Management, Hyderabad\t3 months\n(1st January, 2015 till 31st March, 2015)\tPermanent\n(Received ‘A’ grade for FOCARS)\nScientist \n(Food Technology)\tICAR- National Dairy Research Institute, Karnal\t10th March, 2015 till 31st December, 2018\n(after availing 10 days of transfer period)\tPermanent\nScientist-Senior Scale\n(Food Technology)\tICAR- National Dairy Research Institute, Karnal\t1st January, 2019 till date\tPermanent\n\n7. Special attainments in Research\n(https://scholar.google.co.in/citations?hl=en&user=PRz0Tz4AAAAJ&view_op=list_works&sortby=pubdate)\nPublications\tNumbers\tRemarks \nResearch Articles\t35\n(24 Intl, 9 National, 2 others)\tTotal Impact: 72.302\n\nBook Chapters\t7\t5 APA/CRC Press; 1 InTech Open; \n1 National\nReview Articles\t2\tTotal Impact:8.327\nTechnical Articles\t7\tCompendium of trainings, seminars, etc\nInstitute publication\t1\t\nPopular Article\t12\t6 in English; 5 in hindi\nCitations \t1066\t(as per googlescholar)\nH-index/ i10-index\t15/ 17\t\n.\n.\nJournal\tNumber of publications\tImpact factor\nResearch Articles\t35\t72.302\nInternational\t24 (15 as either corresponding or first author)\t72.302\nNational\t9 (3 as first or corresponding author)\tNAAS score\nOthers\t2\t\nReview article (International)\t2\t8.327\nInternational\t2\t8.327\n.\n \n\n\n\nRESEARCH ARTICLES\nInternational Journals \n1.\tTiwari, S., Upadhyay, N.*, Singh, A. K. (2022). Stability assessment of emulsion of carotenoids extracted from carrot bio-waste in flaxseed oil and its application in food model system. Food Bioscience, 47, 101631. https://doi.org/10.1016/j.fbio.2022.101631.\n2.\tPatil, A. T., Meena, G. S., Upadhyay, N., Khetra, Y., Singh, A. K., & Borad, S. G. (2021). Buffalo milk protein concentrate 60: Effect of skim milk heat treatment on its reconstitutability and functionality. Food Science & Technology – Lebensmittel -Wissenschaft & Tech, 148, 111638. \n3.\tUttamrao, H. J., Meena, G. S., Khetra, Y., Upadhyay, N., Singh, A. K., Arora, S., & Borad, S. G. (2022). Homogenization and sodium hydrogen phosphate induced effect on physical and rheological properties of ultrafilterd concentrated milk. Journal of Food Science and Technology, 59(3), 956-967. \n4.\tTiwari, S., Upadhyay, N.*, Malhotra, R. (2021). Three way ANOVA for emulsion of carotenoids extracted in flaxseed oil from carrot bio-waste. Waste Management, 121, 67-76. \n5.\tRanvir, S., Sharma, R., Gandhi, K., Upadhyay, N., Mann, B. (2020). Assessment of proteolysis in ultra-high temperature milk using attenuated total reflectance–Fourier transform infrared spectroscopy. International Journal of Dairy Technology. 73(2): 366-375. doi: 10.1111/1471-0307.12683. \n6.\tPonbhagavathi, T.R., Singh, A.K., Raju, P.N., Upadhyay, N. (2020). High performance liquid chromatographic (HPLC) determination of available lysine in milk protein-maize composite extrudates and its stability during storage. Journal of the Indian Chemical Society, 97(11a), 2344-2350\n7.\tTiwari, S., Upadhyay, N.*, Singh, A. K., Meena, G. S., & Arora, S. (2019). Organic solvent-free extraction of carotenoids from carrot bio-waste and its physico-chemical properties. Journal of Food Science and Technology, 1-10. 10.1007/s13197-019-03920-5\n8.\tBaria, B., Upadhyay, N.*, Singh, A. K., & Malhotra, R. K. (2019). Optimization of ‘green’extraction of carotenoids from mango pulp using split plot design and its characterization. Food Science & Technology – Lebensmittel -Wissenschaft & Tech, 104, 186-194. \n9.\tPatil, A. T., Meena, G. S., Upadhyay, N., Khetra, Y., Borad, S. G., & Singh, A. K. (2019). Effect of change in pH, heat treatment and diafiltration on properties of medium protein buffalo milk protein concentrate. Journal of Food Science and Technology, 56(3), 1462-1472. \n10.\tUttamrao, H. J., Meena, G. S., Borad, S. G., Punjaram, S. A., Khetra, Y., Upadhyay, N., & Singh, A. K. (2019). Effect of disodium phosphate and homogenization on physico-chemical and rheological properties of buffalo skim milk based ultrafiltered retentate. Journal of food science and technology, 56(5), 2426-2435. \n11.\tMeena, G.S., Dewan, A., Upadhyay, N., Barapatre, R., Kumar, N., Singh, A.K., & Rana, J.S. (2019). Fuzzy Analysis of Sensory Attributes of Gluten Free Pasta Prepared From Brown Rice, Amaranth, Flaxseed Flours and Whey Protein Concentrates. Journal of Food Science and Nutrition Research, 2(1), 022-037. DOI: 10.26502/jfsnr.2642-1100006\n12.\tPatil, A. T., Meena, G. S., Upadhyay, N.*, Khetra, Y., Borad, S., & Singh, A. K. (2018). Production and characterization of milk protein concentrates 60 (MPC60) from buffalo milk. Food Science & Technology – Lebensmittel -Wissenschaft & Tech, 91, 368-374. https://doi.org/10.1016/j.lwt.2018.01.028 \n13.\tUpadhyay, N.*, Jaiswal, P., & Jha, S. N. (2018). Application of attenuated total reflectance Fourier Transform Infrared spectroscopy (ATR–FTIR) in MIR range coupled with chemometrics for detection of pig body fat in pure ghee (heat clarified milk fat). Journal of Molecular Structure, 1153, 275-281. \n14.\tUpadhyay, N.*, Kumar A., Goyal A. and Lal, D. (2017). Complete liquification time test coupled with solvent fractionation technique to detect adulteration of foreign fats in ghee (heat-clarified milk fat). International Journal of Dairy Technology. 70(1): 110-118. doi: 10.1111/1471-0307.12323. \n15.\tUpadhyay, N.*, Goyal A., Kumar A. and Lal, D. (2017). Detection of adulteration of caprine body fat and mixture of caprine body fat and groundnut oil in bovine and buffalo ghee using Differential Scanning Calorimetry. International Journal of Dairy Technology. 70(2): 297-303. May 2017.doi:10.1111/1471-0307.12336. \n16.\tKumar, A., Upadhyay, N.*, Ghai, D.L., Kumar, A. Gandhi, K. and Sharma, V. (2016). Effect of preparation and storage of khoa on physico-chemical properties of milk fat. International Journal of Dairy Technology. 69(2): 294-300. doi: 10.1111/1471-0307.12266. \n17.\tUpadhyay, N.*, Jaiswal, P. & Jha, S.N. (2016). Detection of goat body fat adulteration in pure ghee using ATR-FTIR spectroscopy coupled with chemometric strategy. Journal of Food Science and Technology. 53 (10): 3752-3760. doi:10.1007/s13197-016-2353-2 ISSN 0022-1155\n18.\tRathi, M., Upadhyay, N.*, Dabur, R.S. and Goyal A. (2015). Formulation and physic-chemical analysis of whey –soymilk dahi. Journal of Food Science and Technology. 52(2): 968-975. doi 10.1007/s13197-013-1074-z. ISSN: 0022-1155. \n19.\tKanthale, P., Kumar, A. Upadhyay, N.*, Lal, D., Rathod G. and Sharma, V. (2015). Qualitative test for the detection of extraneous Thiocyanate in Milk. Journal of Food Science and Technology. 52(3): 1698-1704. DOI: 10.1007/s13197-013-1174-9. ISSN: 0022-1155.\n20.\tGoyal, A., Sharma, V., Upadhyay, N., Singh, A.K., Arora, S. and Ghai, D.L. (2015). Development of stable flaxseed oil emulsions as a potential delivery system of ω-3 fatty acids. Journal of Food Science and Technology. 52(7):4256-4265. \n21.\tUpadhyay, N.*, Kumar, A., Rathod, G., Goyal, A. and Lal, D. (2015). Development of a method employing reversed-phase thin-layer chromatography for establishing milk fat purity with respect to adulteration with vegetable oils. International Journal of Dairy Technology. 68(2): 207-217. doi. 10.1111/1471-0307.12178. \n22.\tGoyal, A., Siddiqui, S. Upadhyay, N., Soni, J. (2014). Effects of ultraviolet irradiation, pulsed electric field, hot water and ethanol vapours treatment on functional properties of mung bean sprouts. Journal of Food Science and Technology. 51(4): 708-714. doi 10.1007/s13197-011-0538-2. Publisher Springer. ISSN (electronic version): 0975-8402. \n23.\tKundu, H., Grewal, R.B., Goyal, A., Upadhyay, N.*, and Prakash S. (2014). Effect of incorporation of pumpkin (Cucurbita moshchata) powder and guar gum on the rheological properties of wheat flour. Journal of Food Science and Technology. 51(10):2600-2607. DOI: 10.1007/s13197-012-0777-x. ISSN: 0022-1155. \n24.\tUpadhyay, N.*, Kumar, A., Goyal, A. and Lal, D. (2014). A planar chromatographic method to detect adulteration of vegetable oils in ghee. JPC-Journal of Planar Chromatography-Modern TLC. 27 (6): 431-437. DOI: 10.1556/JPC.27.2014.6.5 \nNational Journals\n1.\tPonbhagavathi, T. R., Singh, A. K., Raju, P. N., Upadhyay, N. (2021). Textural and Sensory Characteristics of Milk Protein-Maize Flour-based Extrudates. Journal of Agricultural Engineering, 58(2), 124-136. 10.52151/jae2021581.1740\n2.\tPonbhagavathi, T.R., Singh, A.K., Raju, P.N., Upadhyay, N. (2020). Effect of Rennet Casein and Whey Protein Concentrate on Extrusion Behavior of Maize Flour. Current Journal of Applied Science and Technology. 39(33), 16-27, Article no.CJAST.57830.\n3.\tUpadhyay, N.*, Kumar, A., Lal, D., Kant, R., & Goyal, A. (2018). Detection of groundnut oil and goat body fat adulteration in ghee using principal component analysis on fatty acid profile. Indian Journal of Dairy Science. 71(5):464-472. \n4.\tUpadhyay, N.*, Kumar, A., Gandhi, K., Goyal, A. and Lal, D. (2014). Standardization of solvent fractionation technique for detection of adulteration in ghee by enriching animal body fat and vegetable oil in different fractions. Indian Journal of Dairy Science. 67 (4):323-327.\n5.\tGandhi. K., Upadhyay, N., Aghav, A.D., Sharma, V., and Lal, D. (2014). Detection of adulteration of ghee (clarified milk fat) with palmolein and sheep body fat using Reichert-Meissl (RM) value coupled with solvent fractionation technique. Indian Journal of Dairy Science. 67(5): 387-393. Received Second Best Paper Award during 44th Dairy Industry Conference organized by ICAR-NDRI, Karnal and Indian Dairy Association from 18-20, February 2016.\n6.\tAghav, A.D., Gandhi, K., Upadhyay, N., Kumar, A. and Lal, D. (2014). A study on the physico-chemical changes occurring in the milk fat during preparation of Paneer. Indian Journal of Dairy Science. 67 (5): 398-404.\n7.\tKumar, A., Upadhyay, N., Gandhi, K., Lal, D. and Sharma, V. (2013). Detection of soybean oil and buffalo depot fat in ghee using Normal-Phase Thin Layer Chromatography. Indian Journal of Dairy Science. 66(4): 294-99. ISSN: 0019-5146.\n8.\tKumar, A., Upadhyay, N., Gandhi, K., Kumar, A., Lal, D. and Sharma, V. (2013). Reverse-Phase Thin Layer Chromatography of Unsaponifiable Matter of ghee for detecting adulteration with soybean oil and buffalo depot fat. Indian Journal of Dairy Science. 66(6): 496-501. ISSN: 0019-5146.\n9.\tUpadhyay, N.*, Dabur R.S. and Rathi, M. (2011). Development and Shelf life Study of Flavoured Whey-soya milk beverage. Indian Journal of Dairy Science. 64(2): 92-101. ISSN: 0019-5146.\nOther Journals\n1.\tDewan, A., Meena, G.S., Upadhyay, N., Barapatre, R. Singh, A.K., Rana, J.S. (2017). Formulation of non-Gluten Pasta from the Optimized levels of Dairy and Non-Dairy ingredients. Madridge Journal of Food Technology. 2(2): 92–98. \n2.\tGalmessa, U., Prasad, S., Kumaresan, A., Oberoi, P. S., Baithalu, R. K., Upadhyay, N., and Dang, A. K. (2015). Modulation of Milk Fatty acid profile milk yield and composition through supplementation of omega-3 fatty acid in transition cow’s diet. Journal of Science and Sustainable Development. 3(1): 25-38. ISSN: 2070-1748\nREVIEW ARTICLES\n1.\tUpadhyay, N.*, Goyal, A. Kumar, A., Lal, D. and Singh, D. (2014). Preservation of milk and milk products for analytical purposes: A review. Food Reviews International. 30(3):203-224. DOI 10.1080/87559129.2014.913292. ISSN: 1525-6103\n2.\tGoyal, A., Sharma, V., Upadhyay, N., Gill, S. and Sihag, M. (2014). Flax and flaxseed oil: an ancient medicine & modern functional food. Journal of Food Science and Technology. 51(9): 1633-1653. DOI 10.1007/s13197-013-1247-9. ISSN: 0975-8402. \nBOOK CHAPTERS\n1.\tKumari, L., Sharma, M., & Upadhyay, N. (2021). Three-Dimensional Printing of Food Products: Printing Techniques, Novel Applications, and Printable Food Materials. Handbook of Research on Food Processing and Preservation Technologies: Volume 3: Computer-Aided Food Processing and Quality Evaluation Techniques, 55. Boca Raton, CRC Press\n2.\tUpadhyay, N.*, Harshitha, C. G., Pathak, N. K., & Sharma, R. (2021). Fourier Transform Infrared (FTIR) Spectroscopy with Chemometrics: Evaluation of Food Quality and Safety. Handbook of Research on Food Processing and Preservation Technologies: Volume 5: Emerging Techniques for Food Processing, Quality, and Safety Assurance, 271.\n3.\tNagarajappa, V., Upadhyay, N., Chawla, R., Mishra, S.K., & Nath, S. (2019). Functional Properties of Milk Proteins. In: Engineering Practices for milk products- Dairyceuticals, Novel Technologies, and Quality (pp 3-26). Apple Academic Press.\n4.\tUpadhyay, N., Kumar, M. C. T., Sharma, H., Borad, S., & Singh, A. K. (2019). Pulse Electric Field Processing of Milk and Milk Products. In: Non-thermal Processing of Foods (pp.129-144). Boca Raton, CRC Press\n5.\tUpadhyay, N., Nagaraj, V., & Singh, A. K. (2019). Advances in Fractionation of Milk Lipids: Analysis and Applications of fractions In: Recent Technologies in Dairy Science (pp. 325-344). Today and Tomorrow’s Printers and Publishers.\n6.\tNagaraj, V., Upadhyay, N.*, Nath, B. S., & Singh, A. K. (2018). Advances in Fractionation and Analysis of Milk Carbohydrates. In Technological Approaches for Novel Applications in Dairy Processing (pp. 127-147). IntechOpen. http://dx.doi.org/10.5772/intechopen.76312\n7.\tUpadhyay, N.*, Veena, N., Borad, S., & Singh, A. K. (2017). Application of Natural Antioxidants in Dairy Foods. In Natural Antioxidants (pp. 281-318). London: Apple Academic Press.\nINSTITUTE PUBLICATION\n1.\tDr. T. K. Datta, Dr. Meena Malik and Dr. Neelam Upadhyay (2017). Foundation Programme for Freshers at ICAR-NDRI 2017.\nPOPULAR AND LEAD ARTICLES\n1.\tPatil, A. T., Meena, G. S., Upadhyay, N., & Singh, A.K. (2017). Milk protein concentrates- Their Applications. Indian Dairyman, 69(9), 44-48.\n2.\tUpadhyay, N.* and R.K. Malik (2015). Nutritive Value of Milk. In: In Touch, Heinz Nutrition Foundation of India. Volume 17, Number 2&3, 2-11. (Lead Article). \n3.\tGoyal, A., Sharma, V., Upadhyay, N., Sihag, M. and Kaushik, R. (2013). High Pressure Processing and its impact on milk proteins: A Review. Research and Reviews: Journal of Dairy Science and Technology. 2 (1): 1-9. ISSN: 2319-3409.\n4.\tKumar, A., Upadhyay, N., and Naagar, S. (2012). Allergenicity of Milk Proteins, and its Management. Indian Food Industry. 31 (5&6): 45-50. ISSN: 0972-2610.\n5.\tGoyal, A. and Upadhyay, N. (2012). Nuclear Magnetic Resonance Spectroscopy in Dairy Science. Indian Food Industry. 31(1): 39-45. ISSN: 0972-2610.\n6.\tUpadhyay, N.*, Goyal, A. and Rathod, G. (2011). Microwave Spectroscopy and its applications in online processing. Indian Food Industry. 30(5&6): 63-73. ISSN: 0972-2610.\n7.\tउपाध्याय, नी*. (२०१८) भारत में कुपोषण: स्थिति और इससे निपटने के लिए रणनीतियाँ. दुग्ध—गंगा (आठवाँ अंक). अप्रैल-सितम्बर. २४-२९. \n8.\tउपाध्याय, नी.*, सिंह, आ.कु., गांगुली, स., सबिखी, ल. (२०१८) खाध्य और डेयरी क्षेत्र मे महिला उद्यमिता: कारण, समस्याए एवम उपलब्ध मंच. दुग्ध—गंगा (आठवाँ अंक). अप्रैल-सितम्बर. ६४-६९.\n9.\tउपाध्याय, नी*. (२०१९) ek¡ dk nw/k % f'k'kqvksa ds ekufld] 'kkjhfjd ,oa lkekftd mRFkku gsrq ve`r. दुग्ध—गंगा (नवाँ अंक). अकटूबर –मार्च १०२-१०४.\n10.\tउपाध्याय, नी*, fç;k ;koys (२०१९) [kk| inkFkksaZ esa —f=e ds cnys çk—frd jax o.kZd ds mi;ksx dh vko';drk दुग्ध—गंगा (दसवाँ अंक). अकटूबर –मार्च १०२-१०५.\n11.\tuhye mikè;k;, fuys'k dqekj ikBd (२०१९) d`f\"k] [kk| ,oa Ms;jh m|ksx ds Hkfo\"; eas lkSj ÅtkZ dk egRo दुग्ध—गंगा (दसवाँ अंक). अकटूबर –मार्च १२६-१३०. \n12.\tवैज्ञानिक और तकनीकी विषय के मूल हिंदी लेख जोकि गेहूँ एवम् जौ स्वर्णिमा में प्रकाशित हुए: उपाध्याय, नी*, राकेश कुमार (2020) महिला उद्यमिता के माध्यम से महिला सशक्तिकरण. गेहूँ एवम् जौ स्वर्णिमा (बारहवााँ अंक), पृष्ठ सं. 55-58; भाकृअनुप- भारतीय गेहूँ एवम् जौ अनुसंधान संस्थान, करनाल- १३२००१ द्वारा प्रकाशित\n\n8. Concepts/Processes/Products/Technologies/Patents/Others\n(i)\tConcepts \nCurrently, I am working on the integrated approach of application of green technology for the development of functional foods by utilizing under-utilized/ indigenous fruits and vegetables and/ or bio-waste. In the research projects, I am also keenly working on food chemistry and instrumental food analysis and applications of technologies/ products in dairy and non-dairy products. \nBesides this, I am working on development of functional food for addressing menopausal symptoms in osteopenic mice model. \n(ii)\tProducts/ Technologies ready for commercialization- 5\n1. Production of Milk Protein Concentrate 60 (MPC60), a high protein low lactose powder from buffalo milk (Co-Inventor)\n2. Technology for omega-3 rich mixed fat table spread (Inventor)\n3. Lipid and water soluble yellow natural colouring ingredient from bio-waste (Inventor)\n4. Technology for preparation of encapsulated flaxseed oil for its applications in foods (Inventor)\n5. Production of buffalo milk based Milk Protein Concentrate 60 (MPC60) powder with improved solubility (Co-Inventor)\n(iii) Expertise on\n1.Gas Liquid Chromatography\t5.Thin Layer Chromatography\n2.Fourier Transform Infra-red Spectroscopy\t6. Spectrophotometry\n3.Differential Scanning Calorimetry\t7.Chemical analysis including titration, distillation, etc.\n4.High Pressure Liquid Chromatography\t\n\n\n9. List of completed, on-going and submitted projects\nTitle of Project\tDuration\tRole\tFunding\tStatus\tRemarks\nEffect of storage on Baudouin test, sesamin test and RP-TLC test to detect adulteration of vanaspati and vegetable oils in ghee\t2015-2017\tCo-PI\tICAR-NDRI\n\tCompleted\tTwo research articles on RP-TLC\nPreparation and Characterization of Micro/nano delivery systems for “green” carotenoids\t2016-2019\tPI\t-Do-\t\t3 research articles+ 3 products/ technologies\nTechnology Development for the Production of Milk Protein Concentrate (MPC60) From Buffalo Milk\t2016-2019\tCo-PI\t-Do-\t\t4 research articles+ 2 products/ technologies\nTechnology of Goat Milk based Functional Beverage\t2017-2020\tCo-PI\t-Do-\t\tOne oral presentation\nTechnology for Moringa oleifera enriched cheese spread\t2020-2023\tPI\t-Do-\tOn-going\tCharacterization and incorporation of M. oleifera- pods in cheese spread is complete; shelf life study and animal trial is in progress\nDevelopment of flaxseed-rich probiotic dairy foods to address menopause symptoms\t2020-2023\tCo-PI\tDST\t\tDeveloped method -estimation of phytoestrogen; validation -in progress\nNutritional and therapeutic validation of chhachh and ghee prepared from indigenous cows by traditional method\tThree years (proposed)\tPI\tSEED Division, DST\tSubmitted \n \t\nCharacterization of Moringa oleifera leaves for functional bioactives and its application in table spread as model food system\tThree years (proposed)\tPI\tSYST, DST\t\t\nOther research work: \nDetection of adulteration of goat body fat and pig body fat in ghee using ATR-FTIR coupled with chemometrics; carried out during Professional Attachment Training at ICAR-CIPHET, Ludhiana\n\n\n\n10. Awards & honours \nName of Award\tYear\tAwarding Agency\nBest Paper Award\t2022\tGSAT (Gender Advancement for Transforming Institutions Self-Assessment Team), NDRI\nBest Poster Award\t2021\tNational Conference on Moringa Food Conclave-2021\nYoung Woman Scientist Award\t2020\tAgro Environmental Development Society during International Web-conference \nSecond Best Poster Award\t2020\tIndian Dairy Association\nCommendation certificate for Institute’s Magazine in which I am co-Editor\t2020\tTown Official Language Implementation Committee, Karnal\nLetter of Appreciation to editorial board of Institute’s magazine for receiving ICAR’s Second Prize and Trophy under Ganesh Shankar Vidyarthi Hindi Patrika Puraskar (2018-19)\t2020\tICAR- National Dairy Research Institute, Karnal\nAssociate Fellowship\t2019\tNational Academy of Dairy Science India\nFirst Prize in E-poster \t2018\tIndian Dairy Association\nOne Best oral Presentation\t2018\tHome Science Association of India\nBest Oral Presentation to my Master’s student\t2018\tICMR- National Institute of Nutrition\nBest Poster Award\t2016\tIndian Dairy Association\nSecond Best Paper Award\t2016\tIndian Dairy Association\nICAR-SRF (PGS) with 2nd rank\t2011-12\tICAR\nGATE (Engg Sciences: Food Tech; Thermodynamics)\t2010\tMHRD, GoI\nInstitution level awards\nThird prize in poster presentation \t2021\tICAR- National Dairy Research Institute, Karnal\nInstitute’s Rajbhasha Gaurav Certificate\t2020\t\nFirst prize in Scientific and Technical writing\t2019\t\nConsolation prize in Scientific and Technical writing \t2020, 2019 \t\nFirst prize in Poster Presentation- 2020, 2018, 2017\t\t\nThird prize in poster presentation\t2019\t\nFirst Prize in hindi extempore\t2017\t\nThird, first and second prize in hindi essay writing in consecutive years – 2020, 2019, 2018\t\t\n\n\n11. Teaching Assignments \n(a) Teaching: Actively involved either as course in-charge or associate \nClass\tB.Tech (DT)\tMSc/ MTech\n(FT) (till 2021)\tM.Tech (DT)\tPhD (DT/ DC/ FSQA)\nNo. of courses\t1-2\t2-3\t0-1\t2-3\nDT- Dairy Technology, DC- Dairy Chemistry, FT- Food Technology, FSQA- Food Safety Quality Assurance\n(b) Student’s guided\nDegree\tMajor Advisor \tCo-Advisory\tStatus/ Remarks\nM. Tech (DT)\t8\t2\tCompleted\n\t1\t0\tOn going\nM. Tech/ M Sc (FT/ FSN)\t2\t1\tCompleted\nM. Tech (DC)\t0\t3\tCompleted\nM. Tech (DM)\t0\t1\tCompleted\nPhD (DT)\t2 \t0\tOngoing \n\t0\t2\tCompleted\nPhD (DC)\t0\t1 \tCompleted\n\t\t1\tOn going\ni.\tThree students under my guidance as major advisor and one student as co-advisory member nominated for Best thesis award; \nii.\tOne represented NDRI at zonal-level student research convention ANVESHAN-2018\n\n12. Lectures/ member/convener of committees: \ni.\tLectures: \na.\tEntrepreneurship Development Programme (EDP) (conducted by SINED-TBI/BPD unit, ICAR-NDRI) and Online Training of Master Trainers on Fat and Oilseed processing conducted by SINED-TBI/BPD unit (ICAR-CIPHET); \nb.\tStudent’s Counselling session at SRCASW, University of Delhi, \nc.\tWorkshop conducted at DAV college, Karnal, etc\nd.\tDelivered talks at various villages on the importance of mother’s milk, nutrition in first 1000 days of an infant’s life, nutri-thali, etc\nii.\tTraining Organized: \na.\tTwenty one days Training at Centre for Advanced Faculty Training (DT Division) on ‘R & D strategies and interventions for effective agribusiness and entrepreneurship development in dairy and food sector’; \nb.\tone/two months or shorter duration trainings for students and others under BPD unit and KVK, NDRI, Karnal\nc.\tFive days training on the aspects of dairy processing to the farmers of Karnal district. \niii.\tGeneral Secretary, Staff Club, NDRI, Karnal\niv.\tMember: Student Empowerment Unit, Conferences organized from 2015 till 2018, convocation, credit seminar evaluation committees; Mera Gaon Mera Gaurav program, Farmer’s First Door programme, Swatchh Bharat Abhiyan, coordinator and mentor of different groups for organizing Foundation Program-2017, 2018, Nodal officer of Poshan Maah-2020 etc\nv.\tConvener/ Rapporteur of sessions: Conference, Dr. K. K. Iya Memorial oration; International conference of Proteomics Society of India\nvi.\tOther responsibilities: Management Representative of QMS-IS/ISO 9001:2008 and HACCP- IS 15000:2013 of Experimental Dairy (essential part of institute) until Jan 2019; one of the editors of Institute hindi magazine Dudgh Ganga which also received coveted award from ICAR (until 2019).\nvii.\tResource Generation on account of consultancy provided in field of dairy processing and by conducting sponsored trainings \nMore than ₹ 2 50 000/- (Two lakhs fifty thousand only)\nviii.\tBesides research, teaching and extension activities, I am also involved in promotion of Hindi language and have won several prizes during competitions (like extempore, essay, e-mail writing) organized by Official Language Units.\nix.\tLifetime Member of three scientific bodies: Indian Dairy Association- RE/NZ/LM/10852/HR; Association of Food Scientists & Technologists (INDIA)- AFST/LM/9-2018/KRN/2444; Lifetime member of Home Science Association of India; Membership number: HSAI-2017-HR-127-LF\nx.\tReviewed research papers of Journal of Ayurveda and Integrative Medicine (Elsevier), LWT, International Journal of Food Properties, Indian Journal of Dairy Science, Indian Journal of Natural Products and Resources, United Scientific Group, etc. \n\n\n\n\n\n\n\n\nDated: 12-04-2022\t \nNeelam Upadhyay",institutionString:"National Dairy Research Institute",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"National Dairy Research Institute",institutionURL:null,country:{name:"India"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"5",title:"Agricultural and Biological Sciences",slug:"agricultural-and-biological-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"444312",firstName:"Sara",lastName:"Tikel",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/444312/images/20015_n.jpg",email:"sara.t@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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1. Introduction
Over the years, benefits have been attributed to fruits and vegetables consumption associated with their content of phenolic compounds with antioxidant activity that may contribute to reduce the risk of cardiovascular diseases and cancer [1]. The antioxidant behavior of phenolic components is related to their ability to chelate metals, inhibit lipoxygenase, and capture free radicals, although sometimes they can also act as promoters of in vitro oxidation reactions [2]. In this way, phenolic compounds act as antioxidants by delaying or preventing autooxidation or oxidation and free radicals sequestration, forming more stable compounds that cannot undergo subsequent oxidations, which allows them to protect low density lipoproteins (LDL) of the human body from oxidation [3]. Antioxidant activity of different foods research, such as fruits, vegetables, and plants in general, have indicated the positive effects of this on diseases control related to oxidative stress [4, 5, 6].
Phenolic compounds are chemical substances that have an aromatic ring attached to one or more hydroxyl groups, including functional derivatives such as esters, glycosides, among others. They have an acidic behavior, since the oxygen of the hydroxyl group is strongly bounded to aromatic ring, while the oxygen and hydrogen bond is relatively weak, which have allowed the proton dissociation that can be released into the medium, causing a phenolate ion negatively charged [7]. They are secondary metabolites distributed in the plant kingdom, from which more than 8000 compounds have been identified that differ in chemical structures and in activity. Its distribution in tissues and cells varies among different fruit and vegetable species and its abundance depends on the species, the type of crop, the part of the plant used, the type of soil, maturity stage, light hours, fertilization, part of the vegetative cycle, among others [8].
These compounds participate in various functions of plants, such as nutrient absorption, protein synthesis, enzymatic activity, photosynthesis, structural components formation, allelopathy, and defense against adverse environmental factors [9]. They are substances responsible for providing fragrances, colors, and flavors to various plants. As an example, anthocyanins are responsible for the red, blue, and violet color of red fruits such as cherries, blackberries, or currants, while flavones are attributed the yellow color of fruits such as lemon or banana. This type of compounds in addition to giving color also contribute by providing characteristics to taste (astringency) of some foods and affecting the sugar/acid ratio of some fruits, as well as being used as a criterion to determine the overall quality of fresh fruits and derived products of these [10]. Among the polyphenols that are considered important in food, are the acids such as gallic, synaptic, ferulic, caffeic, p-coumaric, and their derivatives; as well as the flavonoids and their glycosides [11]. In that sense, phenolic compounds are usually classified into three groups such as flavonoids, phenolic acids, and polyphenols, the most important being the benzoic acid derivatives for their therapeutic use and specifically the flavonoids for having the greatest chemical diversity with approximately 6000 different structures. The profile and quantity of phenolic compounds extracted from plant matrices changes depending on the species, cultivar, season, climate, and other factors such as the cultivation method. However, the extraction performance depends mainly on the solvent polarity used, the extraction method, the duration of the process, and the quantitative and qualitative distribution of the compounds present [3, 11, 12].
The plant extracts, in their majority do not present a unique phenolic component, but, on the contrary, correspond to the mixture of several of these. In that sense, its antioxidant activity will be affected by the concentration of each one in the analysis matrix [3]. This is how there is no single methodology to know the antioxidant capacity of an extract and, therefore, to obtain more comprehensive and complete information, different methods must be used with different mechanisms of action. In addition, due to the heterogeneity of the analytical conditions used, among which are: wavelength, radical generator, time of analysis and how to express the results, is possible to reach values of antioxidant capacity that are not comparable. In that way, in this chapter some generalities about the phenolic compounds with antioxidant activity present in plant matrices will be exposed, also, the principal methods for their extraction and quantification will be described and this information will be complemented with a review on applications of these compounds in food industry.
2. Classification and properties of phenolic compounds
Phenolic compounds can be classified as extractable and non-extractable, as explained below:
Non-extractable polyphenols: these are compounds with high molecular weight, or polyphenols linked to dietary fiber or proteins that can be found in extraction wastes. Include hydrolysable tannins and condensed tannins with a high number of units in the polymer chain. The hydrolysable tannins are polymeric structures that can derive from gallic acid or its condensation dimer product hexahydroxydiphenic acid. The condensed tannins or proanthocyanidins, on the other hand, are polymeric structures, formed by the union of flavan-3-oles, and can be procyanidins, prodelfinidins, and propelargonidins [13].
Extractable polyphenols: these are low or medium molecular weight compounds that can be extracted with aqueous or aqueous-organic solvents. They are classified according to their chemical structure in: flavonoids, which are much more complex structures, which in turn, are subdivided into flavones (chrysin and rutin); flavonols (quercetin and myricetin); flavanols or catechins (epicatechin, epicatechin gallate, epigallocatechin, and epigallocatechin gallate); flavanones (hesperidin and naringenin), anthocyanins (delphinidin, malvidin, and cyanidin) and condensed tannins with a low number of monomers, etc. [13]. On the other hand, non-flavonoid compounds are formed by an aromatic ring substituted by an alcohol in one or more positions and are classified according to the number of carbons they have, within this group can be found: simple phenols, benzoic acids, hydrolysable tannins, acetophenones and phenylacetatic acids, cinnamic acids, coumarins, benzophenones, xanthones, stilbenes, chalcones, lignans, and secoiridoids [14].
Showing up next a description of some of the phenolic compounds present in plant species, including some of their properties and possible applications.
Simple phenolic: these are compounds to which antioxidant, antibiotic, antiparasitic, and cytotoxic properties have been attributed. In general, foods such as cereals are found as resorcinol derivatives [15].
Aromatic carboxylic acids and their derivatives: they occur naturally in many plant species [16] and have been linked to immunostimulant, choleretic, anti-inflammatory, analgesic, antipyretic, and protective properties of the cardiovascular system [11]. The antioxidant properties of phenolic acids have been associated to their capacity to purify free radicals avoiding lipids peroxidation, inhibiting LDL plasma oxidation, and purifying reactive oxygen, which plays a very important role in the promotion of tumors, carcinogenesis. They also act preventively on diseases of the coronary arteries, by decreasing platelet aggregation [17]. Among phenolic acids, antioxidant properties have been attributed as follows: caffeic acid, chlorogenic acid and its isomers, such as 4-O-caffeyl-quinic [18], being the chlorogenic acid the most abundant in plants and the most active antioxidant in this group. It is also known that benzoic acid plays important roles in plant metabolism by regulating their growth and chemically modifying the rhizosphere forming part of the radical exudates; it also increases the capacity to capture minerals when it accumulates in soil in a great concentration [19, 20]. This acid is also a mediator of stress responses, as it is incorporated into numerous secondary metabolites associated with plant-herbivore or plant-pathogen interactions [21].
Acetophenones and phenylacetic acids: they are used as sunscreens in sun creams and o-hydroxybenzophenones are used to protect fibers from photodegradation in the textile industry [11].
Phenylpropanoids: these are products that have a specific role in the response to pathogens or protection from ultraviolet rays, through their antioxidant capacity and energy dissipation, as well as their function as structural components of the cell wall [22]. Due to the phytotoxicity of these compounds, they are stored in their glycosylated form in the vacuoles or conjugated with other components of the cell wall [23]. The cinnamic acid derivatives are abundant in nature in free form (coumaric acid and caffeic acid) or esterified with sugars (caffeyl-tartaric acid), quinic acid (chlorogenic acid), etc. While the benzoic acid derivatives are in free form, such as acids (vanillic acid and gallic acid) or aldehydes (vanillin and anisaldehyde).
Coumarins and related: in plants, these compounds can be present in seed cover, fruits, flowers, roots, leaves and stems, but in general, the highest concentrations are found in fruits and flowers. Its function is related to plant defense, given its antimicrobial, antifeedant, protective properties of UV radiation and inhibiting germination. The pharmaceutical interest for coumarins is due to their vitamin properties, their ability to decrease capillary permeability and an increasing in the strength of capillary walls. They present a wide range of physiological effects in animals, ranging from the less complex element of this group known as simple coumarin, which is toxic to mammals, to the last in the scale that is noboviocin, recognized as a commercial antibiotic [17].
Flavonoids and derivatives: these compounds are widely distributed in plants, especially in leaves, flowers and pollen, as well as in woody parts, such as peduncles and barks. It is known that plants that grow in full sun exposition have more flavonoids than those that grow in the shade, which makes interpreting their presence as a mechanism of plant defense to oxidations promoted by UV light. Among its plant functions, antifungal and bactericidal role is highlighted. Flavonoids have an enormous scientific interest due to the protection they exert against chronic diseases such as cancer and cardiovascular diseases [24, 25]. Flavonoids contain a variable number of phenolic hydroxyl groups in their chemical structure, have excellent chelation properties of iron and other transition metals, which gives them a high antioxidant capacity and therefore, play an essential role in protection against the phenomena of oxidative damage [26, 27].
The growing interest in flavonoids as antioxidants is due to the appreciation of their broad pharmacological activity, since they can bind to biological polymers, such as enzymes, hormone transporters and DNA; chelate transient metal ions, such as Fe2+, Cu2+ and Zn2+, catalyze the transport of electrons and purify free radicals. So, these type of compounds have an interest from a nutritional point of view, since the obtaining and food preparation with a high content of these, supposes a decreasing in the use of antioxidant additives, at the same time as obtaining healthier foods, which can even be considered functional foods [28].
The activity of flavonoids as antioxidants depends on the redox properties of their hydroxyphenolic groups and the structural relationship. For example, it has been determined that chemical criteria that are related to antioxidant capacity of the flavonoids are as follows: (a) the presence of O-dihydroxy structure in the B ring; that gives greater stability to the radical form and participates in electrons delocalization, (b) the double bond in conjunction with 4-oxo function of the C ring and (c) the hydroxyl groups in the three and five positions. Given these concerns, quercetin flavonol is the one that exerts an effective antioxidant function, with a Trolox value of 4.7 mM, which is five times greater than that shown by vitamins E and C and has a water-solubility similar to vitamin E. In addition, the antioxidant function of quercetin shows synergistic effects with vitamin C, since ascorbic acid reduces the quercetin oxidation, in such a way that combined with flavonoid can maintain its antioxidant functions for longer [29]. Another flavonol is kaempferol, a bleaching inhibitor of illuminated chloroplasts, due to the inhibition of the reactions promoted by the triplet of oxygen inside the chloroplast and the protection against thermal autooxidation of palm oils, corn, sunflower, soy, olive, peanut, coconut, butter and margarine [30]. In that sense, polyhydroxylated chalcones, such as butein, have shown considerable antioxidant activity for shortening, being twice as active as quercetin or α-tocoferol. Chalcones with two adjacent hydroxyl groups are almost as effective as butein, however, the presence of additional hydroxyl only slightly increases the inhibitory activity of rancidity, while hydrogenation of the chalcone double bond increases the antioxidant power, is found that pentahydroxydihydrochalcone is 2–3 times more active than the corresponding unsaturated chalcone [31].
Other examples of this type of metabolites are the catechin, epicatechin, gallocatechin, compounds that act as OH’ radical sequestration generated in a Fenton system ranged from 100 to 300 times higher than the effects of mannitol, a typical sequestration of the most toxic from all reactive oxygen-ERO species in vivo generated [32]. In this, there is a positive correlation between phenolic compounds and antioxidant capacity, in this case, the antioxidant capacity depends on secondary metabolites, especially those of phenolic nature such as flavonoids [33].
Tannins: antioxidant activity study of condensed tannins in vitro and in vivo shows that they are effective scavengers of free radicals and they inhibit the tissues oxidation better than vitamin C, vitamin E and β-carotene. In vitro conditions has been shown that condensed tannins have a preference for neutralizing the hydroxyl free radical (•OH), as well as it has been demonstrated that they have the capacity to act as noncompetitive inhibitors of the enzyme xanthine oxidase, one of the biggest generators of free radicals in cellular metabolism [34]. The biological properties of tannins are linked to their capacity to form complexes with macromolecules, particularly with proteins (digestive proteins, fungal or viral enzymes). This explains the problems that its presence can cause in industrial processes associated with food and beverages (cloudiness of beer) production or in agriculture (formation of humic acid, which decreases soybean nutritional value) [15]. Due to tannins affinity with proteins, they can be used as follows: antidiarrheals, in products for skin protection and mucous membranes, vasoconstrictors, skin regenerators, antiseptics, antibacterials and antifungals. Additionally, they act as scavengers of free radicals and inhibitors of superoxides formation, enzymatic inhibitors of 5-lipoxygenase, angiotensin-converting enzyme (ACE), elastase and protein kinase C.
Xanthones, benzophenones and stilbenes: xanthones and benzophenones are present in roots and exotic fruits, while stilbenes have been found in different types of fruits and foods. Its major representative is resveratrol (3,5,4′- trihydroxystilbene), which occurs in grapes, red fruits and peanuts. This compound has an anticancer effect and inhibits reactions that increase the risk of coronary heart disease [35]. Additionally, it has been found to be useful in treatment of various chronic diseases, such as inflammation, arthritis, cardiovascular diseases and delaying aging, while xanthones have shown antiprotozoal activity including activity against Leishmania [15].
Lignans and lignins: these are the most abundant organic substances in plants, after cellulose. These are part of the lignin of the cell wall and participate in plant growth. They also belong to the group of phytoestrogens acting as antioxidants, decreasing the effects of free radicals. There are simple lignans and cyclic lignans that fight against the damaging effects of free radicals and whose compounds like enterodiol and enterolactone have anticancer potential that mimics the functions of human hormones, in addition to inhibiting the growth of breast and prostate tumors [36].
Phenolic diterpenes: this type of compounds are widely known to be potent inhibitors of the linoleic acid oxidation. Its mechanism of action is related to metals chelation by the central beta-diketone group [37].
It can also be included in this review, ubiquinol, which is a product of the ubiquinone (vitamin Q) reduction, a potent antioxidant in vivo conditions of low oxygen concentration, such as those found in many cellular environments, also inhibits the peroxidation of arachidonic acid in emulsion, which have hemoglobin as an initiator and prevents lipids photooxidation in mitochondria. The observed reactivity of ubiquinol with the free radical diphenyl-picryl-hydrazyl suggests that is an antioxidant that breaks the chain reaction and probably reacts in vivo with peroxy radicals [38].
In Table 1 some of these compounds isolated from different plant matrices are presented [39, 40, 41].
2.1. Extraction and quantification of phenolic compounds
Among the techniques used in phenolic compounds extraction are as follows: maceration, digestion, decoction, infusion, percolation, soxhlet, countercurrent extraction, ultrasound-assisted extraction, microwave extraction, extraction with supercritical fluids, extraction with hydrofluorocarbon solvents, micro -extraction in solid phase, partition, chromatography, hydrolytic maceration followed by distillation, hydro-distillation, micro-distillation, molecular distillation, thermo-micro-distillation, among others. In these methods, the solvents used depend on the hydrophilic or lipophilic character of the compounds of interest, thus, for the lipophilic extracts preparation, hexane, diethyl ether and methylene chloride can be used, while for the extraction of hydrophilic compounds, methanol has been used, ethanol, mixtures of ethanol/water, acetone/water and methanol/water and extraction in acidic medium (pH = 2) with methanol/water, followed by acetone/water and water/acetonitrile in acidic medium [14].
Showing up next applications of some solvents according to the polarity:
Water: extraction of anthocyanins, lectins (carbohydrates bound to proteins), polypeptides, saponins, starch, terpenoids and tannins.
Methanol: extraction of antoncianins, lactones, phenols, polyphenols, saponins, tannins, terpenoids and xanthoxillins.
Ethanol: extraction of alkaloids, flavonols, polyphenols, polyacetylenes, terpenoids, steroids and tannins.
Acetone: extraction of alkaloids, coumarins, fatty acids and terpenoids.
Chloroform: extraction of flavonoids and terpenoids.
To minimize the generation of organic waste from extractions and reduce the environmental impact caused by the disposal of toxic solvents used in some extractions, in recent years, the development of sustainable extraction methods has been studied, such as those in which they use acidified water and ethanol as solvents, in addition to the developments in the area of extraction with sub-critical water [14].
2.2. Methodologies for the quantification of phenolic compounds
Depending on equipment availability and the needs of the measurement in terms of costs, precision and speed, quantification techniques can range from simple spectrophotometric analysis to complex chromatographic analysis [43]. Among the spectrophotometric techniques for quantification of phenolic compounds are the Folin-Ciocalteau method, which determines the ability of polyphenols to reduce Mo(VI) to Mo(V), by using the Folin-Ciocalteau reagent (mixed of phosphotungstic acid and phosphomolybdic acid). As a result of such reaction, a color change from yellow to blue is observed [3, 44]. The results of quantification of polyphenols obtained by this methodology, can be expressed in equivalents of gallic acid, catechin, colorgenic, caffeic, protocatecuic, vanillinic or ferulic acid, making it difficult to establish comparisons among different determinations [13]. This methodology can be applied on a routine basis, due to the speed with determinations, which can be made at relatively low costs of these in comparison with other techniques [43]. However, it has been observed that the amount of phenols can be overestimated, since other compounds than phenols (sugars, organic acids, iron (II), nitrogenous compounds and other inorganic substances such as sulfates, phosphates and chlorides) can present interferences due to their reactions with reagent or at the wavelength used (close to 730 nm) in the determination [8, 13]. An example of the methodology is that proposed by García, for the quantification of phenolic compounds in plant extracts [8].
Another spectrophotometric technique is the one used for the quantification of total flavonoids where the ortho-dihydroxylated, meta-hydroxylated and para-hydroxylated flavonoids are chelated by reaction with AlCl3 [45]. However, since plant extracts may vary in their turbidity, is possible that in some samples there are alterations in the results [46]. For anthocyanins measurement, a colorimetric method based on the color change obtained as a result of pH variation can also be used. Taking into account that anthocyanins have a red, violet or purple coloring at acidic pH, while at basic pH, they are green or blue [47]. An example of its application was carried out by Gajula et al., for flavonoids and anthocyanins quantification in a plant extract (Ocimum basilicum L.) [48].
Apart from the spectrophotometric techniques are the chromatographic techniques for phenolic compounds quantification and identification. From these, the simplest technique is the column chromatography based on sample separation as it passes through a column packed with silica that allows compounds separation and their subsequent quantification through the use of a detector used at different wavelengths. Each type of compound is quantified by the preparation of a calibration curve and the results are expressed in terms of concentration or total amount of specific compounds in the analyzed extracts. One of the advantages of this technique when is used for separation and determination of phenolic compounds, is that does not require the previous sample derivatization [49]. Some examples of the application of this type of techniques are reported by Stefenona et al., Sánchez et al., and Martínez [14, 45, 50].
As a complement to chromatographic techniques and to improve the compounds identification found in the extracts, mass spectrometry is currently used, in the analysis of flavonoids extracted from plants [51]. This have allowed to know significant information about the structure of the present compounds even when sample quantities analyzed are very small or correspond to mixtures. With respect to flavonoids characterization applying mass spectrometry, the information obtained can be as follows: (1) the remains of aglycones, (2) types of carbohydrates (mono, di, tri, or tetrasaccharides and hexoses or pentoses) present, (3) the stereochemical assignment of terminal carbohydrate units, (4) the sequence of the glycan part, (5) the inter-glycosidic linkages and (6) points where the substituents bind to the aglycone [52]. Given that there are cases in which mass spectrometry and analysis through high performance liquid chromatography (HPLC) in the UV-Vis spectrum are not sufficient to identify the compounds present in a sample, is necessary to use gas chromatography (GC) coupled to mass spectrometry to achieve more accurate results. However, in the case of gas chromatography for the analysis of non-volatile and thermolabile compounds is necessary to previously carry out their conversion into volatile and thermotolerant chemical derivatives. In this sense, silylation of these compounds has been proposed, prior to GC quantification [49].
2.3. Methodologies for the quantification of antioxidant activity
The measurements of the antioxidant activity can be carried out based on the information you want to obtain:
Direct determination: a radical is used as a quantification factor (since it produces an analytical signal). In this sense, the addition of the antioxidant, before or after the generation of the radical, causes a decreasing in the signal (ABTS•+ or DPPH methods), which is proportional to the antioxidant activity of the sample.
Indirect determination: the presence of free radicals causes the loss or appearance of a reagent and therefore, in the presence of an antioxidant, an increasing or decreasing in the signal is caused (ORAC and FRAP methods) proportional to the antioxidant activity of the sample.
In that way, it is necessary to mention the differences between the free radical stabilizing activity or antiradicalaria (indirect methods) and the antioxidant activity (direct methods), the first being completely determined by the reactivity of an antioxidant against free radicals, characterized by reaction speed, while the second measures the ability to retard oxidative processes [53]. In this sense, the results of the antioxidant capacity measurement obtained by each of the methods do not always coincide, even among methods based on the same redox mechanism, there may be variations. Therefore, it is recommended that an assessment of the antioxidant capacity be carried out using more than one analytical technique and comparisons among results only be made when the same method has been used and samples have been obtained with the same solvents [8, 13].
In general, it has been suggested to combine FRAP and ABTS techniques [54]. This is because the use of the FRAP technique in combination with others such as ABTS and DPPH, allows to evaluate different interactions of the antioxidant compounds, expanding the knowledge about them, which is relevant in the exploration of the antioxidant properties of nutraceutical products from natural sources or simply from some products included in the diet, such as fruits and vegetables [55]. When two techniques are used, as mentioned above, is generally sought that through one of them, is possible to determine the antioxidant activity based on transfer reactions of one electron (SET) and on the other, this same property is determined based on a transfer reaction of a hydrogen atom (HAT for its acronym in English) between an antioxidant and a free radical, allowing to evaluate the two mechanisms to extend the spectrum of the results obtained [8]. In Figure 1, the HAT and SET mechanisms are showed.
Figure 1.
Mechanisms of antioxidant reacting with free radical: single electron transfer (SET) and hydrogen atom transfer (HAT).
Table 2 summarizes the principal methods to quantify the antioxidant activity [13].
Regarding the expression of results of antioxidant capacity, several methods (FRAP, ABTS and ORAC) express the results in μmol Trolox/g of sample on dry or wet basis (Trolox is a water-soluble analog of vitamin E). Likewise, these results can be expressed in terms of vitamin C and E. In summary, a suitable method for the quantification of antioxidant activity should consider the electron transfer and hydrogen atoms reaction, establish the oxidation substrate, ensure that the substrate and how to induce oxidation, became relevant in terms of oxidative damage, be simple, have a mechanism and a defined endpoint, use available and affordable instrumentation, be reproducible, be adaptable to measure hydrophilic and lipophilic antioxidants, use different sources of free radicals with relevant biological characteristics and be adaptable for routine large-scale analyzes [13].
This is increasingly important, since is known that no single method reflects the total antioxidant capacity of a sample, that is, its ability to act as an antioxidant of lipophilic and hydrophilic compounds through specific mechanisms, in addition to its reactivity against different species [56]. In addition, is known that the antioxidant activity of a sample is not only given by the sum of the antioxidant capacities of the components present in it, but also depends on the synergistic and inhibitory effects that may exist among compounds and the microenvironment in which this one is [57].
2.3.1. Principal methods for in vitro antioxidant activity quantification
In Table 3, the advantage and disadvantages of in vitro antioxidant activity determination methods will be presented.
Group
Number of carbons
Plant matrix
Compound or type
Simple phenolic
C6
Banana
Transcinnamic acid
Benzoic acid
C6–C1
Strawberry
p-Hydroxybenzoic
Acetophenones and phenylacetic acids
C6–C2
Blueberry
Phenylpropanoids
C6–C3
Grapes
Coumarins
C6–C3
Tangerine, orange, lemon
Caffeine acid, scopolin
Flavonoids
C6–C3–C6
Cherry, orange, grape, soybeans
Isoflavones, quercetin, cyanidin
Tangerine, orange
Flavanones
Parsley, celery, oreganum
Flavones
Apple, pear
Flavonols
Grapes
Flavanols
Benzophenones and stilbenes
C6–C1–C6
Grapes
Resveratrol
Xanthones
C6–C2–C6
Mangosteen, mango
Mangiferine
Lignans and lignins
(C6–C3)n
Passion fruit, lime, fruits with bone
Daidzein
Table 1.
Classification of phenolic compounds.
Principle
Method
Metal reduction
Ferric ion-reducing antioxidant power (FRAP)
Peroxyl radical absorption capacity
Oxygen radical absorbance capacity (ORAC) Total radical-trapping antioxidant parameter (TRAP)
Hydroxyl radical absorption capacity
Deoxyribose assay
Capacity for radicals absorption generated from certain organic molecules
This method has a high sensitivity, is practical and fast. Is used to evaluate the antioxidant potential in plants, food and drink. Additionally, is a stable and soluble radical both in aqueous and organic media, allowing the evaluation of hydrophilic and lipophilic antioxidants; with the advantage that its spectrum has maximum absorbance at 414, 654, 754 and 815 nm in alcoholic medium, which represents a greater availability of wavelengths to carry out determinations, avoiding color interference. Correlations have been observed among ABTS values and the polyphenol content determined by the Folin-Ciocalteau method, especially when measurements are carried out at the beginning of the reaction (after 2 min) than when data came from measurements at longer times (15 min), which could be because in the first part of the reaction are the polyphenols that react, while in the second part are other metabolites derived.
In this case, the radical must be previously generated and reaction kinetics with some antioxidants can be slow, causing the determination of the endpoint to be carried out arbitrarily. This has led to differences in the literature regarding the time taken to carry out the determinations (between 1 and 7 min) affecting the antioxidant activity values, since the TEAC determination is dependent on the incubation time, as well as the relationship between the amount of sample and ABTS• concentration. It has also been found that the type of solvent used in antioxidants extraction from the sample influences the results obtained. In addition, as this technique is based on mechanisms of hydrogen atom transfer, the reactivity patterns and the reaction mechanism are difficult to interpret when the chemical structure of the evaluated antioxidant is unknown.
Method based on the power that an antioxidant substance has to reduce Fe3+ to Fe2. In this sense, 2,4,6-tripyridyl-s-triazine (TPTZ) colorless ferric compound used in the test is reduced to a colored ferrous complex. Among its advantages is that the redox potential of Fe3−TPTZ is comparable with that of the ABTS allowing to analyze similar compounds with both methods, although the reaction conditions are different. This technique, having as a base mechanism the metal reduction used as chain reaction propagator of lipid peroxidation through breakdown of hydroperoxides to alkoxyl radicals, allows its use to correlate the antioxidant activity with the ability of the compounds to act as prooxidants, in addition to its ferric ion-reducing capacity.
These types of techniques are quite sensitive to ascorbic acid and uric acid, compounds that could reduce the ferric ion to ferrous ion and react with the latter to generate new free radicals. Also, being based on an electron transfer mechanism, this technique does not allow detecting compounds that act by the hydrogen transfer mechanism. In addition, any compound with a redox potential lower than 0.7 V could reduce Fe(III), overestimating the value obtained for the activity.
In this method, DPPH• reacts with the sample in such a way that the determination is carried out indirectly by monitoring the decreasing in absorbance at 515 nm. A modification of this method, introduce kinetic parameters like EC50 (effective concentration of the antioxidant necessary to reduce by 50% the initial amount of radical), tEC50 (time necessary to reduce by 50% the initial amount of radical with the given antioxidant concentration) and the antiradical efficiency (AE) calculated based on the aforementioned parameters, which also have allowed to establish relationships between the concentration of phenolic compounds and their antioxidant activity. These kinetic parameters are determined as follows: AE=1/EC50∗tEC50 At higher AE, better the performance of the antioxidant even at low concentrations and in short times. Among the advantages of this method are the stability of the organic radical, which does not have to be generated in situ and its simplicity by not requiring sophisticated equipment.
It is known that many substances have an absorption spectrum that overlaps with the only maximum absorption that the radical presents interfering with the measurement. Additionally, its application is restricted to the fact that only allows measuring the activity of lipophilic compound
It is based on the ability of antioxidant compounds to block free radicals by hydrogen atom donation. In this method, the AAPH (2,2’-Azobis-(2-aminopropane)-dihydrochloride) artificial radical, oxidizes fluorescein in such way that fluorescein loses its fluorescence. Among its advantages is that it is easy to follow when using a colored or fluorescent probe. In addition, the use of a protein as a substrate prevents the substrate itself from generation of free radicals due to its oxidation. Likewise, the method is used to determine the antioxidant capacity of aqueous and hydrophobic samples, varying the source of radicals and the solvent. On the other hand, based on a mechanism of hydrogen atoms transfer, in this method, the reactions are of approximately 30 min to guarantee the reaction stabilization, independent of pH and solvent.
It is found that the fluorescein solution must be prepared daily, the reaction kinetics may vary depending on the antioxidant concentration, the temperature and the presence of metals and reducing agents. In addition, the results may be affected by the solvent used in the extraction and by non-antioxidant compounds present in plant foods, such as some amino acids and uronic acids, which become interferences, providing overestimated results.
CBA (Method of crocin decolorization or ß-carotene)
This method is based on crocin or β-carotene oxidation, natural derivatives of the carotenoids, by peroxyl radicals generated from AAP. For quantification, the crocin discoloration rate is measured in the presence and absence of antioxidants at 434 nm. In this sense, carotenoids can be decolorized by three main routes as follows: autoxidation, oxidation induced by heat or light and oxidation induced by peroxyl radicals (generated by AAPH generator or by lipids oxidation). This bleaching can be prevented or diminished by the addition of some antioxidant compounds capable of donating hydrogen atoms to neutralize free radicals. Among the advantages of this method are its simplicity and speed, in addition to the fact that it does not require specialized equipment for the determination.
The wavelength at which is measured coincides with food pigments (carotenoids), which can lead into a variability in the measurements. In addition, the reaction mechanisms of different antioxidants with crocin may vary, affecting the interpretation of the results. Another disadvantage is the low crocin availability (mixture of natural pigments extracted from saffron) that induces variability in the measurements.
In this method, the absorbance at 532–535 nm of a chromogenic complex formed between thiobarbituric acid and malondialdehyde (MDA) is measured, which is a by-product of the lipid oxidation of polyunsaturated fatty acids of at least 3 double bonds. It is considered a rapid, sensitive and economic measurement technique.
It is lack of specificity, since thiobarbituric acid reacts with a variety of aldehydes in addition to those formed during lipid peroxidation, in such way, the analysis in biological fluids is limiting. Another disadvantage is that malondialdehyde and other short chain products are not stable for long periods of time.
It is one of the most widely used technique to determine antioxidant activity in fluids. As an advantage, this methodology allows to determine the non-enzymatic antioxidant capacity of the tissue through a hydrogen atom transfer mechanism. In this assay, a hydrophilic radical generator and a substance that detects these radicals, such as phycoerythrin, are used. In this way, the oxidation is initially inhibited during a latency period by the antioxidant and what is done is to compare the duration of this period for the sample against Trolox.
Different endpoints for the reaction have been proposed in its application, preventing the results comparison. In addition, not all antioxidants have a fully established inhibition phase, making this method inaccurate when comparing compounds that exhibit different inhibition behaviors in fluorescence in a given oxidant system.
In DMPD method the free radical generated in the presence of an oxidizing solution of ferric chloride and acidic pH, becomes a colored and stable cationic radical, which has a maximum of absorbance at 505 nm. The experimental procedure is rapid, economical, sensitive and reproducible in the quantification of the antioxidant activity of hydrophilic compounds and in some cases lipophilic.
The technique is performed at a pH that is not physiological and reaction time that is required to perform the measurement (ranged from 18 to 21 h).
It is based on the oxidation of alpha-keto-gamma-methylbutyric acid to ethylene by the action of hydroxyl, peroxyl and peroxynitrite radicals generated from 2,2-azobis amidinopropane (ABAP). The TOSC value is found by results comparison obtained for the sample with those of a pattern. As advantages of this methodology application is its availability for the total capacity measurement of oxiradical elimination in biological tissues and the possibility of used it to discriminate different oxyradicals indicating the functions of these species or their metabolic pathways.
In reaction kinetics, there is no dose-response relationship between the amount of antioxidant and the percentage of inhibition, preventing comparisons among results.
It is a method to assess the concentration and antioxidant capacity in biological samples, in samples from the food industry and in cosmetics. In addition, this method measures the total antioxidant capacity of a sample. This design is based on Cu(II) to Cu(I) reduction by the combined action of all antioxidants (reducing agents) in a sample. The CUPRAC assay uses a related compound neocuproin (2,9-dimethyl-1,10-phenanthroline), the Cu(I) complex which absorbs at 450 nm.
Slowly reacting antioxidants required an incubation at 50 °C for 20 min for color development. Certain compounds also needed incubation after acid hydrolysis for color development.
Oxidation method of LDLs (Low density lipoproteins)
In this method, the oxidation of LDLs isolated from different individuals is induced by different elements and compounds such as Cu2+ or AAPH and subsequently, the absorbance at 234 nm is measured, which is absorbed by the conjugated dienes generated during the oxidation process of LDLs.
I some cases the duration of the determination is too long.
This method measures the ability of an antioxidant or mixture of antioxidants to capture the hydroxyl radical. Is based on reaction of 2-deoxyribose (DR) when is oxidized in the presence of hydroxyl radical generated by the Fenton reagent in such way that malondialdehyde (MDA) is produced. MDA is mixed with 2-thiobarbituric acid (TBA) in acidic medium which allows the development of a pink color chromogen that can be measured at an absorbance of 532 nm. Higher absorbance values would indicate higher levels of OH• radicals [13, 65]. As an advantage, this assay has been widely used to determine the antioxidant activity of foods and medicines.
There may be a strong alteration of the result when working with ethanolic extracts due to the interference caused by alcohol on the measurement.
It is an enzyme dehydrogenase that catalyzes the oxidation of hypoxanthine or xanthine to uric acid, by transferring an electron to the nicotinamide-adenine-dinucleotide (NAD). During the XO reoxidation, molecular oxygen acts as an electron acceptor producing radical superoxide and hydrogen peroxide.
Modifications to this method have also been developed in which the reaction is not monitored through determining changes in absorbance at 295 nm, but through HPLC or where what is determined is the evolution in uric acid formation and it can increase the cost and complexity of the method.
Principal methods for in vitro antioxidant activity quantification.
2.3.2. Principal methods for in vivo antioxidant activity quantification
There are different techniques to perform these measurements among which are as follows [68].
Techniques based on lipid oxidation:
Malondialdehyde (MDA): a breakdown of lipid hydroperoxides generated from polyunsaturated fatty acids generates different aldehydes, such as MDA, which is also produced in food and can be absorbed in the gastrointestinal tract.
Exhaled alkanes: in this technique the exhalation of volatile hydrocarbons, mainly ethane and pentane, derived from the oxidation of polyunsaturated fatty acids, is measured. The principal advantage of this method is that is a non-invasive procedure.
Ex vitro oxidation of LDLs: this method consists of subjecting the LDLs isolated from a particular subject to the same oxidation process, in order to observe their basal level of antioxidants or the effects of an antioxidant supplementation.
Techniques based on protein oxidation:
Within these techniques, three biomarkers have been used: 2-aminoadipic-semialdehyde (AAS), gamma-glutamic semialdehyde (2-GGS) product of the lysine and proline oxidation, respectively (supposed as the major products of protein oxidation), and nitrosine, oxidized derivative of proteins that can be generated by action of peroxynitrite or peroxidase.
3. Quantification of antioxidant activity and phenolic compounds in plant extracts
In Table 4, a compilation of information associated with the analytical methods and the conditions used for the quantification of antioxidant capacity and total polyphenols in plant extracts, is presented.
Fruits such as: acai, banana, star fruit, purple prune, curuba, peach, strawberry, passion fruit, guava, apple guava, kiwi, lulo, tangerine, tommy mango, red apple and Colombian vegetables such as: garlic, white bulb onion, red bulb onion, cauliflower, spinach, capira potato, etc.
Analytical methods for the quantification of antioxidant capacity and total polyphenols.
4. Application of plant extracts with antioxidant activity in food processing
In Table 5, a list of some applications of plant extracts in food processing will be presented, highlighting its use in conservation processes improvement and shelf life extension.
Antioxidant
Application
Concentration
Results
Refs.
Achiote
Biodegradable container for palm oil
Proportion of the natural additive (0.25, 0.5 and 1%, respectively)
During the storage period (45 days), a decreasing in phenolic content (17.8–36.2%) was observed in the additive used to make the packaging and a decreasing in the peroxide value of the three evaluated formulations in comparison with controls. The protective effect of natural additive was established, since the one that underwent the oxidation processes was the additive and not the palm oil. The results were directly proportional to the used concentration. The incorporation of this natural additive did not change the mechanical and barrier properties of the containers.
During the storage period (45 days) under accelerated oxidation conditions (63% UR/30°C), the total polyphenol losses in the films (40% total loss) correlated with a lower increase in the peroxide value of the packaged product, demonstrating, in such way, instead of the product, the packaging compounds were those that underwent the oxidation processes. The yerba mate extract did not alter the mechanical and barrier properties of the films.
Prune extract showed antioxidant properties in products such as irradiated turkey, precooked pork sausage and roasted meat. However, in slices of ham the results were not adequate due to an increasing in cooking loss, values of cutting force and redness. The sensory quality of products derived from meat and poultry treated with prune products presented minimal differences with respect to untreated products.
The extract of grape seed has been shown to have an antioxidant potential 20 and 50 times higher than vitamin E and vitamin C, respectively. Numerous studies concluded that is an effective antioxidant for the preservation of raw and cooked pork. Likewise, it has been determined that the use of ActiVin (extract of grape seed) at 1.0% in minced meat, inhibits TBARS values by 92%. Likewise, it was established that low concentrations of grape seed extract, ≤0.2%, do not present adverse effects on sensory characteristics such as color, odor and taste, while concentrations higher than 1% affected the color of the finished products.
The antioxidant activity of bearberry have allowed a significant decreasing in lipid oxidation compared to control under refrigeration conditions, the effect being greater in raw meats than in cooked ones. Likewise, it has been reported that bearberry did not generate differences in color, taste, texture and juiciness.
10 mg of phenolic equivalents of tannic acid/100 g in fresh chicken
By using pomegranate powder in hamburgers preparation and refrigerating them for a period of 15 days, a greater reduction of TBARS values was observed in comparison with BHT control (68%). Likewise, it was determined that pomegranate powder and pomegranate juice powder have little effect on sensory or quality attributes when used in concentrations of 5–20 mg equivalents of phenolic tannic acid/100 g of meat. Similar results have been obtained in raw goat meat, where the reduction was 67%.
It has also been reported that the use of blueberry powder juice at 0.32% in turkey meat and cooked pork meat, have allowed to inhibit the lipid oxidation almost 10 times compared to control. This is attributed to the fact that this fruit has a high concentration of phenolic compounds (158.8 μmol of total phenols/g of dry weight) and especially of anthocyanins, which can inhibit the oxidation of lipids.
The extract delayed the initial oxidation of lipids and the effect was dose dependent, likewise it was determined that inhibited the generation of molecules responsible for unwanted odors. The extract did not have significant inhibitory effects on the enzymatic hydrolysis of lipids.
Oxidation control of sunflower oil and soybean oil
5, 10, 50, 100 and 200 ppm
The oil conservation tests were carried out under accelerated conditions (72 h at 70°C) evaluating the action of natural extracts and synthetic antioxidants on the change in the peroxide value of the oils. It was observed that the action associated with an increasing in the peroxide index varied as follows: TBHQ> potato peel extract> BHT = sugar beet pulp> BHA.
The study confirmed the potential of osmotic treatments for food development that incorporate functional ingredients such as antioxidants in a successful manner. It was observed that molecular weight of the phenolic compounds limits their penetration during treatment.
The protective effect of the extract against lipid oxidation of frozen raw chicken meat stored at freezing conditions (−18°C) was demonstrated. There were some differences in the color of the cooked product and its aroma, however these results were not very different from those obtained using synthetic antioxidants.
Addition of 300 mg, 600 mg and 1 g of extract in 500 g bread
A decreasing in the antioxidant activity of the extract added to the bread was observed due to the thermal process involved in its elaboration. However, the use of the extracts has allowed to enrich the bread in compounds with antioxidant activity. The results showed that the addition of appropriate amounts of the extract contributed to the development of favorable changes in the bread color without altering the sensory properties thereof.
Extract in cookie mass 0.5, 1, 2 and 3%, respectively
The extract was used to control the oxidation of fats and oils present in cookies in such way that their shelf life could be prolonged. The extracts showed better results in comparison with those obtained using BHA, this perhaps due to its greater stability during the production process of the product.
Substitution of sodium erythorbate by natural extracts in lamb burgers
Concentration equivalent to 500 ppm of sodium erythorbate
The substitution did not affect the sensory quality of the product and managed to reduce the changes caused by meat deterioration, converting these plant extracts in a healthy alternative for the formulation of meat derivatives.
The natural antioxidants used in the elaboration of meat products (pork, chicken, goat, and cow) manage to reduce lipids and proteins oxidation in different meat matrices.
Concentrations: 1% rosemary extract, 1% clove extract and mix 0.5% from each extracts.
The chicken was stored for 15 days at 4°C. As a control, the synthetic antioxidant BHT was used. It was demonstrated that the extracts of the studied spices showed a high effectiveness against microbial growth and lipid oxidation, demonstrating their potential as natural antioxidants for raw chicken meat.
3000 mg of rosemary extract/kg, a positive control of 50 mg of TBHQ/kg and extract mixture with TBHQ, were evaluated.
The assay included the addition of the antioxidant to the oil and its heating at 180°C for 20 h. Time during which determinations of oxidative stability, total polar compounds, tocopherol content and fatty acid profile, were carried out. The addition of the extract increased the oxidative stability and resulted in a low formation of polar compounds and a high retention of tocopherols. In the treatment with rosemary extract, a high amount of polyunsaturated fatty acids was observed after 20 h. No synergies were observed between the rosemary extract and TBHQ in terms of preventing the oil oxidation.
A reduction of lipid oxidation was observed in the studied samples, which was followed by color changes and metmyoglobin concentration. The extract demonstrated ability to delay the lipids degradation present in the muscle of the meat.
During storage, the amount of phenolic compounds added to the product decreased slightly, while the lipid oxidation increased slightly. Mango shell extracts showed greater efficiency in the control of lipid oxidation against other extracts such as santol and rambutan. It was also determined that the treatments that included mango shell extract presented lower rancidity than control (without addition of antioxidants) after 10 days of storage. Mango extract applied at 0.2% (v/w) in pork meatballs showed the greatest effectiveness against lipid oxidation.
Potato immersion in a extract solution of 0.5, 1 and 1.5%, respectively
A decreasing in the speed change of the color parameter “L”, corresponding to the brightness, had achieved by extract addition. The potatoes treated with the extract, presented a lower darkening than potatoes that were not treated during storage at 5°C and 55% of relative humidity.
Applications of plant extracts with antioxidant activity in food processing.
Other applications can be found in the works developed in food matrices that include meats, oils, fruits, vegetables and cereal products [106].
5. Conclusions
The compiled information in this work demonstrates the need to continue developing techniques for the extraction of phenolic compounds with antioxidant activity from plant species in order to improve the obtained yields, have greater control over the extracts composition and their mechanism of action, to facilitate their implementation in food industry, where they can find great acceptance due to their natural character and their properties to lessen the impact of diseases attributed to the oxidation processes proper to human organism.
\n',keywords:"extraction, food additives, natural products, phenolic compounds, vegetal species",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/60554.pdf",chapterXML:"https://mts.intechopen.com/source/xml/60554.xml",downloadPdfUrl:"/chapter/pdf-download/60554",previewPdfUrl:"/chapter/pdf-preview/60554",totalDownloads:2032,totalViews:1259,totalCrossrefCites:5,totalDimensionsCites:13,totalAltmetricsMentions:0,impactScore:4,impactScorePercentile:90,impactScoreQuartile:4,hasAltmetrics:0,dateSubmitted:"November 22nd 2017",dateReviewed:"February 14th 2018",datePrePublished:"April 6th 2018",datePublished:"July 11th 2018",dateFinished:"April 6th 2018",readingETA:"0",abstract:"Plants have phenolic compounds with antioxidant activity. These compounds are distributed in tissues and cells of plants and their abundance depends on the species, the part of the plant used, maturity stage, light hours, among others. On the other hand, the profile and quantity of phenolic compounds extracted from plant matrices changes depending on the species, cultivar, climate, and other factors. Plant extracts do not present a unique phenolic component, they correspond a mixture and its antioxidant activity will be affected by the concentration of each one and their action depends on this composition. In this chapter, some generalities about the phenolic compounds with antioxidant activity present in plant matrices will be exposed, also the principal methods for their extraction and quantification will be described and this information will be complemented with a review on applications of these compounds in food industry. In that sense, the reader can infer the importance of continue to studying and developing techniques to obtain, extract, and characterize this kind of compounds, also they can identify possible application of them, the most important, they can recognize them as an alternative to replace chemical synthetized antioxidants used in food industry improving the market of natural products.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/60554",risUrl:"/chapter/ris/60554",book:{id:"6678",slug:"antioxidants-in-foods-and-its-applications"},signatures:"Ludy C. Pabón-Baquero, Ángela María Otálvaro-Álvarez, Margarita\nRosa Rendón Fernández and María Patricia Chaparro-González",authors:[{id:"236194",title:"M.Sc.",name:"Ludy C.",middleName:null,surname:"Pabón Baquero",fullName:"Ludy C. Pabón Baquero",slug:"ludy-c.-pabon-baquero",email:"lupabon@unisalle.edu.co",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"236204",title:"MSc.",name:"Margarita R.",middleName:null,surname:"Rendón F.",fullName:"Margarita R. Rendón F.",slug:"margarita-r.-rendon-f.",email:"mrendon@unisalle.edu.co",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"236205",title:"MSc.",name:"María Patricia",middleName:null,surname:"Chaparro G.",fullName:"María Patricia Chaparro G.",slug:"maria-patricia-chaparro-g.",email:"mchaparro@unisalle.edu.co",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"236206",title:"Dr.Ing.",name:"Ángela María",middleName:null,surname:"Otálvaro Álvarez",fullName:"Ángela María Otálvaro Álvarez",slug:"angela-maria-otalvaro-alvarez",email:"amotalvaro@unisalle.edu.co",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/236206/images/7180_n.png",institution:{name:"Universidad de La Salle",institutionURL:null,country:{name:"Costa Rica"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Classification and properties of phenolic compounds",level:"1"},{id:"sec_2_2",title:"2.1. Extraction and quantification of phenolic compounds",level:"2"},{id:"sec_3_2",title:"2.2. Methodologies for the quantification of phenolic compounds",level:"2"},{id:"sec_4_2",title:"2.3. Methodologies for the quantification of antioxidant activity",level:"2"},{id:"sec_4_3",title:"Table 1.",level:"3"},{id:"sec_5_3",title:"2.3.2. Principal methods for in vivo antioxidant activity quantification",level:"3"},{id:"sec_8",title:"3. Quantification of antioxidant activity and phenolic compounds in plant extracts",level:"1"},{id:"sec_9",title:"4. Application of plant extracts with antioxidant activity in food processing",level:"1"},{id:"sec_10",title:"5. Conclusions",level:"1"}],chapterReferences:[{id:"B1",body:'Proteggente A, Pannala A, Paganga G, Van Buren L, Wagner E, Wiseman S, Van de Put F, Dacombe C, Rice-Evans C. 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1. Introduction
Antrochoanal polyp (ACP) is a benign, unilateral polyp originating from the maxillary sinus, extending through the natural or accessory ostia into the nasal cavity. This finding is more common in children and young adults [1] with 2:1 male to female ratio. Its etiology is vague and varies from neoplasia to inflammatory polyp or cystic degeneration of intramaxillary retention cyst. The exact anatomic origin of ACP inside the maxillary sinus is not agreed upon in the literature. The medial and posterior walls are the most common origin sites [2, 3], but the polyp may grow from virtually any site inside the maxillary sinus. ACP exits the maxillary sinus through the accessory ostium in at least 70% of cases [4], which may explain why the polyp grows inferiorly and posteriorly into the nasopharynx. Recent publications show evidence that nearly all ACPs extend through the accessory ostium [2, 5]. The most common symptoms of ACP are nasal obstruction and anterior nasal discharge, while epistaxis and pain point towards a different etiology necessitating further workup. The treatment of choice for ACP is surgical resection [1]. While different surgical techniques were described in the past, endoscopic removal of both the intranasal and intramaxillary parts of the polyp is the common practice today. ACP is common in the pediatric population. While it represents only 4–6% of all nasal polyps in adults, up to 35% of nasal polyps in children will eventually be diagnosed as ACP [6]. The common symptoms are the same as with adults, however additional sinus pathologies are rarely seen in children. Oropharyngeal descent is more prevalent in children compared with adults [7]. In addition, children generally present with more advanced disease, probably as a result of delayed diagnosis. The recurrence rate of ACP after endoscopic surgical treatment is not significantly different between children and adults [8]. A meta-analysis conducted by Galluzzi demonstrated a 15% recurrence rate in children with significantly higher rates in patients who underwent endoscopic surgical treatment alone compared with combined approach (i.e. endoscopic and trans-canine sinusoscopy or mini-Caldwell-Luc) [9].
2. Pathophysiology
There are different theories regarding the pathogenesis of ACP; Early studies suggested that ACP grows from an antral mucous retention cyst, a quite common finding in the general population (8–10%) [10]. In their attempt to explain why ACP occurs in only a minority of patients with retention cysts, Frosini et al. hypothesized that increased intra-sinus pressure caused by partial occlusion of the natural ostium due to inflammatory changes and edema is leading an antral cyst to herniate through the accessory ostium [5]. Histologic features of ACP, which include a high rate of inflammatory cells, may support this theory.
The association between ACP and allergy is controversial. While the exact pathogenesis of ACP is unknown, a relationship between ACP and allergic rhinitis or ipsilateral maxillary sinusitis has been shown in pediatric patients [7]. Moreover, increased recurrence rates of ACP after endoscopic surgery were noted in children who were exposed to cigarette smoke (aka ‘passive smokers’); Mantilla described a series of 27 cases of recurrent ACP in children in which nearly half of the subjects were considered as passive smokers [11]. While this data may point to a causal correlation between smoking and the development of ACP, such a relationship is not documented elsewhere and more research is needed in this area.
3. Differential diagnosis
The diagnosis of ACP may be challenging, mainly in young children (5–8 years). In this age group, adenoid hypertrophy is a very common finding and the symptoms may resemble those of ACP, like nasal obstruction, chronic rhinorrhea and snoring. Even though the pre-operative management in these cases include nasal endoscopy and/or lateral plain films of the neck, sometimes the diagnosis of ACP may be overlooked. Another unilateral nasal pathology to be ruled out in children is foreign body but it usually manifests with unilateral foul-smelling rhinorrhea. Epistaxis is not a usual clinical feature of ACP. In these cases, vascular lesions (such as juvenile nasopharyngeal angiofibroma, hemangioma or hemangiopericytoma) and neoplasia (inverted papilloma or malignant tumors) should be excluded [12]. The key to differentiate between ACP and other pathologies is a thorough and detailed history along with meticulous physical examination. In cases of limited physical examination, imaging may contribute to the diagnosis. One should keep in mind that adenoid to nasopharynx ratio decreases with age (especially in children >8 years) due to a change in nasopharynx width [13]. Therefore, children older than 8 years must undergo complete nasal flexible endoscopy to rule out nasal polyp (Table 1).
Adenoiditis / Hypertrophy
Antrochoanal polyp
Allergic rhinitis
Rhinosinusitis
Age
Variable, 4–7 years
7 years <
7 years <
Any age (acute) 12 years < (chronic)
Etiology
Hypertrophy of adenoid tissue
Cystic enlargement of intramaxillary polyp
Inflammatory/ allergic
Infectious (acute) inflammatory (chronic)
Symptoms
Nasal obstruction snoring chronic rhinitis
Nasal obstruction (unilateral progressive to bilateral) rhinorrhea
Differential diagnosis of pediatric nasal obstruction [14].
4. Clinical manifestations
4.1 History
The most common presenting symptoms of ACP are nasal obstruction and anterior rhinorrhea. Nasal Obstruction may be unilateral or bilateral, depends on the evolution of growth of the polyp. When it emerges from the maxillary sinus ostium to the nasal cavity the patient will complain on unilateral nasal obstruction. However, as the polyp further descends into the choana it may cause bilateral obstruction, as commonly seen in hypertrophic obstructive adenoid tissue. Rhinorrhea is usually unilateral and watery; purulence is rarely seen. Other symptoms may include mouth breathing, snoring and sleep disorders, although ACP does no lead to truly obstructive sleep apnea (OSA). The cystic component is very typical to ACP. Some patients report of a sudden watery or yellow drainage followed by a relief of the nasal obstruction implying to a spontaneous rapture of the cystic part in the ACP.
Very large polyps may descend into the oropharynx and cause a foreign body sensation. As previously noted, the presentation of bilateral nasal obstruction is possible due to expansion of the polyp from one choanae to the other, however true bilateral ACP is extremely rare [15].
5. Imaging
Computed tomography (CT) imaging with nasal endoscopy represent the gold standard in the diagnosis of ACP [5]. All patients must have preoperative sinonasal CT scan, as it is a crucial part of the diagnosis and provides critical information of nasal and sinus bony landmarks prior to surgical intervention.
The classic appearance of ACP in CT is a hypo-attenuating unilateral soft tissue mass that completely occupies the maxillary sinus. It extends through the accessory maxillary ostium into the nasal cavity, medially to the inferior turbinate with progression towards the nasopharynx (Figure 1). Less commonly, the polyp extends anteriorly to the middle turbinate and the anterior inferior turbinate region [16]. Bony changes (bone erosion, destruction or sclerosis) are not typically seen with ACP, although widening of the accessory maxillary ostium may occur, usually due to enlarging cystic portion of the polyp leading to the appearance of expansile maxillary mass (Figure 1) [8]. In cases of suspected bone destruction in CT, other pathologies such as malignancy should be considered. However, studies have shown that thinning of alveolar bone in the maxillary sinus may occur secondary to the progressive growing of ACP [2]. Lee classified 3 stages of ACP based on the radiological appearance of the lesion on CT [3, 17]: Stage I (antronasal polyp without extension to the nasopharynx), Stage II (full occlusion of the maxillary sinus ostium with extension to the nasopharynx) and Stage III (partially occlusion of the maxillary sinus ostium with polyp extension to the nasopharynx). In children, advanced CT stages (stage II, III) are more commonly seen due to delayed diagnosis in this population, as previously noted [7]. Magnetic resonance imaging (MRI) shows a hypointense T1 and enhanced T2 signals. With gadolinium administration, the cystic part of the polyp is peripherally enhanced. Although CT is the preferred imaging modality in the diagnosis of any nasal or sinus pathology including ACP, MRI may be considered in children (due to the lack of radiation exposure) and in cases of total unilateral nasal and sinus opacification in CT scans (in order to distinguish between sinus secretions and the mass itself). In nasal endoscopy, ACP appears as a gray-white colored mass with a smooth round surface. Unlike other allergic or inflammatory nasal polyps, ACP has a unique course from the maxillary sinus to the choana and has a bulging expansile behavior due to its cystic component.
Figure 1.
Computed tomography (CT) imaging of right-sided antrochoanal polyp (ACP). (A) coronal image showing total opacification of the right maxillary sinus and nasal cavity. The antrochoanal polyp has both an intramaxillary component (black asterisk) and an intranasal component (black arrow) this view also demonstrates the enlarged accessory maxillary ostium (white arrow) through which the intramaxillary and intranasal portions are connected via a thin stalk. (B) Coronal view of choanal component of the polyp (white asterisk) obstructing the nasopharynx on the ipsilateral side. (C) and (D) axial and sagittal views demonstrating the different components of the antrochoanal polyp intra-maxillary (black asterisk), intranasal (black arrow) and choanal / nasopharyngeal (white asterisk) potions.
6. Histology/histopathology
Macroscopically, ACP is composed of a cystic part filling the maxillary sinus and a solid part emerging through the maxillary ostia and filling the nasal cavity. It has a gross appearance of a “dumbbell” shape with a narrow stalk connecting between the cystic and solid components (Figure 2). Microscopically, the antral (or intra-maxillary portion) part of ACP demonstrates a central cystic cavity surrounded by a homogeneous edematous stroma with few cells [5]. The intranasal portion of the polyp is covered with a respiratory epithelium similar to the normal mucosa of the sino-nasal tract and the choanal portion occasionally shows squamous metaplasia and reactive fibrosis (Figure 3). In comparison to allergic polyp, ACP is characterized by higher inflammatory cell infiltration and edema, lower eosinophilic infiltration and less submucosal glands [18]. These findings indicate that inflammatory changes are the main pathophysiological processes in the pathogenesis of ACP while allergy plays only a minor role. In addition, the paucity of submucosal glands suggests that ACP results from edematous hypertrophy of the respiratory epithelium rather than from distention of the glandular structure, which is the event responsible for the development of ordinary nasal polyps [18]. Angiogenesis is significantly less evident in ACP compared to nasal polyps resulting from chronic rhinosinusitis, with lower expression of angiogenic markers vasculo-endothelial growth factor (VEGF) and CD-34 [12]. These findings further support the idea that ACP is a result of a local inflammatory process and could also explain why ACP has less tendency to bleed compared with other types of polyps, both as a presenting symptom or during endoscopic surgery. ACP is characterized with a significantly high prevalence of intramural cysts [19, 20]. It is speculated that these cysts may have a role in the pathogenesis of ACP, and they contribute to the gross cystic appearance of both its intramaxillary and intranasal components. Moreover, the presence of intramural cysts supports Berg’s theory [10, 20] that the cystic part of the polyp develops from obstruction in the acinar glands or lymphatic ducts secondary to persistent inflammation. The pressure generated in the process of the polyp’s growth through the accessory sinus ostium may be the cause for the substantial edema that is seen.
Figure 2.
Combined radiologic and intraoperative views of a left-sided Antrochoanal polyp. (A) & (B). Coronal and axial images showing total opacification of the left maxillary sinus and nasal cavity. The intra-maxillary portion (black asterisk) and the intranasal portion (black arrow) are connected through the enlarged accessory maxillary ostium (white arrow). (C). Endoscopic view of the same patient: The intranasal component of the polyp (black arrow) is medialized with a sinus-seeker (white cross) exposing the stalk (white arrow) that connects it to the intramaxillary component (black asterisk). (D). Gross appearance of the antrochoanal polyp after resection. The intranasal (black arrow) and the choanal (white asterisk) portions are seen clearly, the stalk preserved (white arrow) is seen after separating it from the intra-maxillary portion. MT = middle turbinate. S = nasal septum.
Figure 3.
Typical histologic characteristics of ACP. Image (A) shows a cystic portion of ACP with cuboidal epithelium (H&E original magnification X200). Image (B) demonstrate the intranasal portion of the ACP, edema is seen (H&E X100). Images (C) & (D) demonstrate squamous metaplasia of choanal portion of the ACP (C- H&E X200, (D)- monoclonal P63 antibody stain x200).
An explanation of why ACP presents with more cystic changes than diffuse chronic rhinosinusitis with nasal polyps (d-CRS) may be related to their different origins. ACPs develop from the maxillary sinus, characterized by typical respiratory epithelium with thin lamina propria, cyst formation and fewer submucosal glands. On the contrary, nasal polyps in d-CRS typically originate from the ethmoid sinus, which has a thick submucosal layer [21].
When comparing ACP with d-CRS preparations, Warman et al. found that ACP exhibits typical histologic features like cyst formation and edema. ACP demonstrated significantly increased edema when compared to the d-CRS (82.5% vs. 44.4% respectively, p < 0.001), and higher cyst formation (40% vs. 6.2% P = 0.02). More over ACP preparations demonstrate lower degrees of inflammatory markers than d-CRS [22]. The lack of an inflammatory drive in the pathogenesis of ACP may explain why anti-inflammatory treatment is futile in this population, leading to the common notion that ACP is a rather surgical issue than a medical one.
7. Treatment
Surgery is the standard of care in the treatment for ACP. Since its first description by Killian in 1906, many surgical techniques have been proposed for exposing the maxillary region [4]. Successful ACP resection depends on complete removal of the intramaxillary component of the polyp. The ideal procedure should facilitate excellent approach to all maxillary sinus walls and yet be minimally invasive as possible, especially in children. Currently, various surgical approaches are available: endoscopic sinus surgery (ESS) with polyp removal via either inferior meatus or middle meatus, or a combined inferior and middle meatal naso-antral window. Other options such as ESS with adjuvant canine fossa puncture, or ESS with “mini Caldwel-Luc” procedure aim to facilitate visualization of the anterior and inferior walls of the maxillary sinus [4, 23, 24].
8. Endoscopic inferior meatal antrostomy (EIMA)
Described by Mikulicz in 1887, inferior meatal antrostomy (known as intranasal antrostomy) was a common surgical procedure in the management of maxillary sinus disease. However, the popularity of this technique has declined with the increased use of middle meatal antrostomy due to the growing recognition that an opening in the inferior meatus does not improve sinus drainage, and might even harm the maxillary sinus mucociliary clearance mechanism. Nevertheless, endoscopic approach via inferior meatal antrostomy has the advantage of inferior meatal naso-antral window that avoids violation of the ostiomeatal complex (OMC) and provides better access to anterior-inferior maxillary sinus lesions. Arguments against inferior meatal antrostomy include: persistent sinus disease following surgery, low patency rates, possible injury to the nasolacrimal duct or to developing canine teeth, and technical difficulties associated with the procedure [24, 25]. While these arguments were substantial using anterior rhinoscopy approach, they are not valid with endoscopic approach in EIMA. As the inferior turbinate is carefully medialized, the opening of the nasolacrimal duct (Hasner’s valve) is clearly seen and preserved. Then, the maxillary wall is penetrated posterior to that point, and an antrostomy of 8–10 mm is created. Once a satisfactory exposure is achieved, view of the posterior, lateral and anterior portions of the sinus walls is possible with 0- and 45-degree endoscope in respect. The lesion is then removed with straight and curved instruments. At the end of the procedure, the inferior turbinate is lateralized back to its original position [24, 25].
Landsberg and Warman reported 56 patients with multiple maxillary pathologies (45% of them with ACP) in which EIMA was the primary approach for revision surgery. In a follow-up period for at least a year, 93% of patients had no evident sinus disease recurrence. There were no cases of ACP recurrence, and recirculation was not observed during the follow-up period. In addition, no major complications such as nasolacrimal duct injury or bleeding were observed [24].
9. Endoscopic middle meatal antrostomy (EMMA)
Endoscopic sinus antrostomy via the middle meatus (EMMA) is currently considered the gold standard treatment for ACP resection. It is generally recommended that the antral portion should be completely removed together with its stalk to minimize polyp regrowth. As a result, the intranasal and choanal components of the polyp should be resected first (Figure 2). Occasionally when the choanal portion is too large, it is easier to push it back to the oropharynx and remove it trans-orally.
Next, the cystic part of the polyp is resected through maxillary antrostomy. The maxillary sinus natural ostium is identified and usually connected with the already enlarged accessory ostium. Resecting the intramaxillary portion includes −45°-70°- endoscopes to better visualize and identify the origin of the polyp. Removal of this intramaxillary portion is extremely important as to minimize post-operative recurrence [4, 26, 27].
Recurrence rate after EMMA is low. Cook et al. observed no recurrence in 33 patients with ACP [28]. Sometimes the intramaxillary portion is tightly adherent to the anterior or antero-inferior walls of the sinus, which makes the dissection a challenging task. In these cases, usage of angled instrumentation is strongly recommended. Nevertheless, the recurrence rate in these cases may increase up to 20% [17, 24, 26, 27].
Ozer et al. reviewed 42 patients who underwent ESS for ACP removal. Transcanine sinoscopy and Caldwell Luc approach were used in addition in 14 and 13 patients respectively. They found recurrence in 3/15 patients after ESS alone (20%), yet there was no recurrence after combined ESS and transcanine sinoscopy or the Caldwell Luc approach [29]. They postulated that the relative high recurrence rate may be due to improper identification of the attachment site of the polyp inside the maxillary sinus (50% of all cases). As a result, they advised considering combined approaches in cases when the attachment site is not clearly recognized. Hong et al. recommended powered instrumentation (Hummer, Stryker Instruments, Kalamazoo, MI) during ESS as an effective technique for removing ACP, especially the antral portion. They found an improvement rate of 96.4% with no significant complications when powered instrumentation was used [29, 30]. Complications following ACP resection are rare.
10. Combining endoscopic middle meatal antrostomy and transcanine sinusocopy
Lee and Huang used the transnasal endoscopic approach for ACPs originated from the inferior and posterior walls of the maxillary sinus, saving the more invasive combined endoscopic and transcanine approach for polyps originated from the lateral wall or in revision surgery. They reported success rate of the transnasal endoscopic approach and the combined endoscopic middle meatal and transcanine approach as 76.9% and 100%, respectively [31].
As mentioned earlier, Ozer et al. found no recurrence after combined ESS and transcanine sinoscopy approach [29].
Transcanine exposure has some complications such as facial swelling pain and rarely injury to the infraorbital nerve. Although rare these complications yet are against using transcanine procedure in ACP resection, especially if the polyp is approachable via EIMA.
11. Combination of ESS and “mini Caldwell-Luc” approach
Kelles et al. retrospectively reviewed 46 patients treated for ACP during a 7-year period. 20 patients underwent endoscopic endonasal surgery (ESS) with mini-Caldwell operation (performing a canine fossa window of 0.5–0.6 cm), while 26 patients underwent ESS alone. The only statistically significant difference between the groups was the recurrence rate, which was higher in the ESS group compared with ESS plus mini-Caldwell group (P < 0.05).
In the ESS group, bleeding, synechia, and ostium stenosis were more evident than in the ESS plus mini-Caldwell group, but these differences were not statistically significant. Therefore, Kelles theorized that adding the mini Caldewell-Luc approach allowed better visualization of the maxillary sinus walls and subsequently easier resection of the remnant polyp [23].
Atighechi et al. used a mini-Caldwell approach with ESS in their patients. They reported minimal recurrence and low complication rates, deciding that the technique is useful for the completely removal of ACP [32].
The traditional Caldwell-Luc approach offers good exposure and ensures complete removal of the polyp with the associated antral mucosa. Nevertheless, this approach has been largely abandoned in the treatment of maxillary sinus pathologies, because it does not address the natural ostium of the maxillary hence considered non-functional. Complications include: cheek anesthesia, sensory deficits, cheek swelling and risks for normal teeth development in children [4, 23, 29, 33, 34].
12. Special consideration in ACP resection; ESS in children
As previously noted, the incidence of ACP is higher in children and young adults. Although no difference in the pathophysiology or histology were seen between children and adults, children are at higher risk for recurrence. It is reasonable to believe that the anatomically narrow sinuses, the not-yet erupted teeth, and concern of maxillary growth may affect the surgeon’s decision regarding the surgical approach, leading to higher failure rate [17, 31, 35].
In his review of 200 patients with ACP, Forsini described recurrence in 4 patients (2%) all of which were children <7 years of age, in whom only polypectomy was performed. Eventually, in all cases of recurrence ESS was performed without evidence of recurrence [4].
13. Recurrence and follow up
As evident by various published series, recurrence rates range from 0% reported by Tsukidate to 64% reported by Saito and collaborators. Recurrence rates vary between different surgical approaches, patient’s age and other factors such as accompanying sinus pathologies [36, 37]. This raises the question – how long should we follow patients ACP resection?
Lee and Huang determined that 65% of their pediatric patients with ACPs had associated chronic sinusitis. Similarly, some authors have also identified association of ACPs with allergic disease. The main hypothesis is the challenge of removing the entire sick mucosa with the origin of the polyp once there is chronic inflammation [31]. Natasha Choudhury reported 29 patients after EMMA surgery for ACP. They described no polyp recurrence, with a mean follow-up period of 14.7 months [8]. Galluzzi reviewed 13 studies and found that recurrence in children is higher than in adults, mostly because of reasons described earlier. The review showed that combined approach had the lowest recurrence rate, with a range of follow-up between 6 to 120 months. Most recurrences were noted between 5 months to 3 years after initial surgery [17]. Some authors claim that different anatomic variations in the nasal cavity such as septal deviation, conchal hypertrophy, and concha bullosa may increase the intramaxillary pressure, hence predisposing for the development of ACP. While these variations were documented in up to 80% of patients with ACP, none of them were linked to increased rates of recurrence [4, 17, 23, 24, 30]. In most relevant studies, the time of recurrence was 1.2 ± 0.6 years. Therefore, it is advised to monitor ACP patients for at least 2 years after surgery in order to detect 95% of recurrent cases [35].
14. Conclusion
ACP originates in the maxillary sinus of children and young adults. Its etiology is speculative, currently considered a benign cystic polyp with limited inflammatory characteristics. It has a consistent three component structure intramaxillary, intranasal and choanal portions. ACP has a typical imaging characteristic and the gold standard of treatment is complete surgical resection. Special attention should be given to identify and resect the intramaxillary portion to prevent recurrence. Long term follow-up is needed to rule out polyp regrowth.
\n',keywords:"histoloy, Immunohistochemistry, antrochoanal polyp, nasal polyps",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/75691.pdf",chapterXML:"https://mts.intechopen.com/source/xml/75691.xml",downloadPdfUrl:"/chapter/pdf-download/75691",previewPdfUrl:"/chapter/pdf-preview/75691",totalDownloads:385,totalViews:0,totalCrossrefCites:0,dateSubmitted:"December 12th 2020",dateReviewed:"February 1st 2021",datePrePublished:"March 12th 2021",datePublished:"December 8th 2021",dateFinished:"March 12th 2021",readingETA:"0",abstract:"Antrochoanal polyp (ACP) is a benign unilateral polyp, originating from the maxillary sinus and expanding through the accessory or natural ostia into the nasal cavity and choanae. It has a 2: 1 male predominance and is more common in children and young adults. The exact pathophysiology is unclear, and it is thought to have less of the inflammatory reactions as opposed to typical bilateral nasal polyps which are commonly seen in diffused chronic rhinosinusitis. The presenting symptoms of ACP are unilateral nasal obstruction and rhinitis. Epistaxis, pain, and foul-smelling secretions are not typically seen and point towards a different etiology. Diagnosis is mainly clinical via endoscopic examination and supported by Computed tomography (CT) imaging. In CT images the three components of the polyp can be identified; an intramaxillary portion, intranasal and choanal components. Treatment is surgical, where Endoscopic sinus surgery (ESS) is the main technique used with other assisting approaches to reach the more challenging anterior and inferior areas of the maxillary sinus. Successful resection depends on complete removal of the intramaxillary component of the polyp to avoid polyp regrowth. The typical histologic characteristics are cyst formation, fibrosis and squamous metaplasia that are significantly more common in ACP than diffused nasal polyps.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/75691",risUrl:"/chapter/ris/75691",signatures:"Warman Meir, Rona Bourla, Monica Huszar and Elchanan Zloczower",book:{id:"9630",type:"book",title:"Pathology",subtitle:"From Classics to Innovations",fullTitle:"Pathology - From Classics to Innovations",slug:"pathology-from-classics-to-innovations",publishedDate:"December 8th 2021",bookSignature:"Ilze Strumfa and Guntis Bahs",coverURL:"https://cdn.intechopen.com/books/images_new/9630.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83881-859-3",printIsbn:"978-1-83881-858-6",pdfIsbn:"978-1-83881-860-9",isAvailableForWebshopOrdering:!0,editors:[{id:"54021",title:"Prof.",name:"Ilze",middleName:null,surname:"Strumfa",slug:"ilze-strumfa",fullName:"Ilze Strumfa"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"323764",title:"M.D.",name:"Meir",middleName:null,surname:"Warman",fullName:"Meir Warman",slug:"meir-warman",email:"meirwarma@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"343528",title:"Dr.",name:"Rona",middleName:null,surname:"Bourla",fullName:"Rona Bourla",slug:"rona-bourla",email:"rona83@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Kaplan Medical Center",institutionURL:null,country:{name:"Israel"}}},{id:"343529",title:"Dr.",name:"Elchanan",middleName:null,surname:"Zloczower",fullName:"Elchanan Zloczower",slug:"elchanan-zloczower",email:"chanani9@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Kaplan Medical Center",institutionURL:null,country:{name:"Israel"}}},{id:"344199",title:"Dr.",name:"Monica",middleName:null,surname:"Huszar",fullName:"Monica Huszar",slug:"monica-huszar",email:"monica_h@clalit.org.il",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Kaplan Medical Center",institutionURL:null,country:{name:"Israel"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Pathophysiology",level:"1"},{id:"sec_3",title:"3. Differential diagnosis",level:"1"},{id:"sec_4",title:"4. Clinical manifestations",level:"1"},{id:"sec_4_2",title:"4.1 History",level:"2"},{id:"sec_6",title:"5. Imaging",level:"1"},{id:"sec_7",title:"6. Histology/histopathology",level:"1"},{id:"sec_8",title:"7. Treatment",level:"1"},{id:"sec_9",title:"8. Endoscopic inferior meatal antrostomy (EIMA)",level:"1"},{id:"sec_10",title:"9. Endoscopic middle meatal antrostomy (EMMA)",level:"1"},{id:"sec_11",title:"10. Combining endoscopic middle meatal antrostomy and transcanine sinusocopy",level:"1"},{id:"sec_12",title:"11. Combination of ESS and “mini Caldwell-Luc” approach",level:"1"},{id:"sec_13",title:"12. Special consideration in ACP resection; ESS in children",level:"1"},{id:"sec_14",title:"13. Recurrence and follow up",level:"1"},{id:"sec_15",title:"14. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Lee TJ, Huang SF, et al. Endoscopic sinus surgery for antrochoanal polyps in children. Otolaryngol Head Neck Surg. 2006; 135(5):688-692'},{id:"B2",body:'Bidkar VG, Sajjanar AB, et al. Role of computed tomography findings in the quest of understanding origin of antrochoanal polyp. Indian J Otolaryngol. Head Neck Surg. 2019; 71(3):1800-1804'},{id:"B3",body:'Lee DH, Yoon TM, et al. Difference of antrochoanal polyp between children and adults. Int J Pediatr Otolaryngolol. 2016; 84:143-146'},{id:"B4",body:'Frosini P, Picarella G, et al. Antrochoanal polyp: analysis of 200 cases. Acta Otolaryngology Ital. 2009; 29 (1):21-26'},{id:"B5",body:'Yaman H, Yilmaz S, et al. Evaluation and management of antrochoanal polyps. Clin Exp Otorhinolaryngol 2010; 3: 110-114'},{id:"B6",body:'Larsen K, Tos M, et al. The estimated incidence of symptomatic nasal polyps. Acta Otolaryngol. 2002; 122: 179-182'},{id:"B7",body:'Balikci HH, Ozkul MH, et al. Antrochoanal polyposis: analysis of 34 cases. Eur Arch Otolaryngology. 2013; 270 (5):1651-1654'},{id:"B8",body:'Choudhury N. Hariri A, et al. Endoscopic management of antrochoanal polyp: a single UK centre’s experience. Eur Arch Otorhinolaryngol. 2015; 272(9) 2305-2311'},{id:"B9",body:'Mantilla E, Villamor P, et al. Combined approach for paediatric recurrent antrochoanal polyp: a single-centre case series of 27 children. J Laryngo Otol. 2019; 133(7): 627-631'},{id:"B10",body:'Min YG, Chung J, et al. Histologic Structure of Antrochoanal Polyps, Acta Oto-Laryngologica. 1995; 115:4, 543-547'},{id:"B11",body:'Gendeh BS, Long YT, et al. Antrochoanal Polyps: clinical presentation and the role of powered endoscopic polypectomy. Asian J Surg. 2004; 27(1):22-25'},{id:"B12",body:'Hirshoren N, Neuman T, et al. Angiogenesis in chronic rhinosinusitis with nasal polyps and antrochoanal polyps. Inflamm Res. 2011; 60 (4):321-327'},{id:"B13",body:'Cohen O, Betito HR, et al. Development of the nasopharynx: A radiological study of children. Clin Anat. 2020 Oct;33(7):1019-1024'},{id:"B14",body:'Flint P.W (2020) Cummings Otolaryngology - Head and Neck Surgery (7th Ed.) chapter 200; Pediatric Chronic Rhinosinusitis 2970-2978. Elsevier'},{id:"B15",body:'Oner F, Sakat M, et al. Bilateral Antrochoanal Polyp. J Craniofacial Surg. 2015; 26 (7): 661-662'},{id:"B16",body:'Peric A, Vucadinovic T, et al. Choanal polyps in children and adults: 10-year experience from a tertiary hospital. Eur Arch Otorhinolaryngol. 2019; 276(1) 107-113'},{id:"B17",body:'Galluzzi F, Pignataro L, et al. Recurrences of surgery for antrochoanal polyps in children: A systematic review. Int J Pediatr Otolaryngol. 2018; 106:26-30'},{id:"B18",body:'Stammberger H, Hawke M. Essentials of functional endoscopic sinus surgery. St Louis: Mosby 1993. p. 103-105'},{id:"B19",body:'Maldonado M, Martínez A, et al. The antrochoanal polyp. Rhinology. 2004;42(4):178—182'},{id:"B20",body:'Berg O, Carenfelt C, et al. Origin of the choanal polyp. Arch Otolaryngol Head Neck Surg 1988; 114:1270-1271'},{id:"B21",body:'Latta JS, Schall RF. LXXVIII The Histology of the Epithelium of the Paranasal sinuses under Various Conditions. Ann Otol Rhinol Laryngol. 1934;43(4):945-971. Doi:10.1177/000348943434300401'},{id:"B22",body:'Warman M, Kamar Matias A, et al. Inflammatory Profile of Antrochoanal polyps in the Caucasian Population – A Histologic Study. Am J Rhinol Allergy 2020 Accepted for publication.'},{id:"B23",body:'Kelles M, Toplu Y, et al. Antrochoanal polyp: clinical presentation and retrospective comparison of endoscopic sinus surgery and endoscopic sinus surgery plus mini-Caldwell surgical procedures. J Craniofac Surg. 2014;25(5):1779-1781'},{id:"B24",body:'Landsberg R, Warman M, et al. The Rationale for Endoscopic Inferior Meatal Antrostomy. ORL 2019; 81:41-47'},{id:"B25",body:'Yanagisawa E, Christmas DA Jr, et al. Endoscopic view of a long-term inferior meatal antrostomy. Ear Nose Throat J. 2007;86(6):318-319'},{id:"B26",body:'Pagella F, Emanuelli E, et al. Clinical features and management of antrochoanal polyps in children: Cues from a clinical series of 58 patients. Int J Pediatr Otorhinolaryngol. 2018; 114:87-91'},{id:"B27",body:'Stammberger H, Posawetz W, et al. Functional endoscopic sinus surgery. Concept, indications and results of the Messerklinger technique. Eur Arch Otorhinolaryngol. 1990;247(2):63-76'},{id:"B28",body:'Cook PR, Davis WE, et al. Antrochoanal polyposis: a review of 33 cases. Ear Nose Throat J. 72:401-410, 1993'},{id:"B29",body:'Ozer F, Ozer C, et al. Surgical approaches for antrochoanal polyp: a comparative analysis. B-ENT. 2008;4(2):93-99'},{id:"B30",body:'Hong SK, Min YG, et al. Endoscopic removal of the antral portion of antrochoanal polyp by powered instrumentation. Laryngoscope. 2001;111(10):1774-1778'},{id:"B31",body:'Ta-Jen Lee, Shiang-Fu Huang, et al. Endoscopic sinus surgery for antrochoanal polyps in children. Otolaryngol Head Neck Surg 2006; 135:688-692'},{id:"B32",body:'Atighechi S, Baradaranfar MH, et al. Antrochoanal polyp: a comparative study of endoscopic endonasal surgery alone and endoscopic endonasal plus mini-Caldwell technique. Eur Arch Otorhinolaryngol 2009; 266:1245-1248'},{id:"B33",body:'Paul W. Flint. Cummings Otolaryngology--Head & Neck Surgery. 5th ed. Elsevier Saunders, 2014. ISBN: 9781455746965'},{id:"B34",body:'Datta RK, Viswanatha B, et al. Caldwell Luc Surgery: Revisited. Indian J Otolaryngol Head Neck Surg. 2016;68(1):90-93'},{id:"B35",body:'Chaiyasate S, Roongrotwattanasiri. K, et al. Antrochoanal Polyps: How Long Should Follow-Up Be after Surgery? Int J Otolaryngol. 2015; 297417'},{id:"B36",body:'Tsukidate T, Haruna S, et al. Long term evaluation after endoscopic sinus surgery for chronic pediatric sinusitis with polyps. Auris Nasus Larynx 2012;39(6)583-7'},{id:"B37",body:'Saito H, Honda N, et al. Intractable pediatric chronic sinusitis with antrochoanal polyp, Int. J Pediatr Otorhinolaryngol. 2000 31;54(2-3):11-6'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Warman Meir",address:"meirwarma@gmail.com",affiliation:'
Department of Otorhinolaryngology, Head and Neck Surgery, Kaplan Medical Center, Israel
Hebrew University, Hadassah Medical School, Israel
Department of Otorhinolaryngology, Head and Neck Surgery, Kaplan Medical Center, Israel
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Food insecurity disproportionately affects newcomers in Canada; unfortunately, they occupy the lower end of the socio‐economic spectrum and thus adding to the burden of socio‐cultural challenges they are already facing. The high level of food insecurity contributes to poor diet quality and the rise in overweight and other chronic health conditions and therefore to the loss of healthy immigrant status. Indeed, statistical evidence, mainly of the overall Canadian population, demonstrates that individuals living in food‐insecure households have higher rates of self‐reported poor health and chronic health conditions. Therefore, understanding and properly addressing the factors associated with food insecurity among Canadian immigrants is crucial for an adequate integration of immigrants. This chapter suggests that an adequate and appropriate understanding of food security for Canadian immigrant populations requires consideration of a cultural perspective in addition to the traditional individual, household and community levels and the development of measurement tools to capture this cultural dimension. It is proposed the concept of cultural food insecurity encompasses the four usual dimensions (availability, accessibility, utilization, and stability) and a newly proposed fifth cultural dimension. Future research should aim at validating the relevance of this cultural perspective as a fifth pillar for food security and developing measurement tools to assess it.",signatures:"Diana Tarraf, Dia Sanou and Isabelle Giroux",authors:[{id:"192842",title:"M.Sc.",name:"Diana",surname:"Tarraf",fullName:"Diana Tarraf",slug:"diana-tarraf",email:"dtarr064@uottawa.ca"},{id:"193533",title:"Dr.",name:"Dia",surname:"Sanou",fullName:"Dia Sanou",slug:"dia-sanou",email:"dia.sanou@fao.org"},{id:"193603",title:"Dr.",name:"Isabelle",surname:"Giroux",fullName:"Isabelle Giroux",slug:"isabelle-giroux",email:"igiroux@uottawa.ca"}],book:{id:"5598",title:"People's Movements in the 21st Century",slug:"people-s-movements-in-the-21st-century-risks-challenges-and-benefits",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"192385",title:"Dr.",name:"Ortal",surname:"Slobodin",slug:"ortal-slobodin",fullName:"Ortal Slobodin",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"192435",title:"Dr.",name:"Fanli",surname:"Jia",slug:"fanli-jia",fullName:"Fanli Jia",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Seton Hall University",institutionURL:null,country:{name:"United States of America"}}},{id:"192625",title:"Prof.",name:"Carlo",surname:"Contini",slug:"carlo-contini",fullName:"Carlo Contini",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"192779",title:"Prof.",name:"Félix",surname:"Neto",slug:"felix-neto",fullName:"Félix Neto",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Porto",institutionURL:null,country:{name:"Portugal"}}},{id:"192842",title:"M.Sc.",name:"Diana",surname:"Tarraf",slug:"diana-tarraf",fullName:"Diana Tarraf",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ottawa",institutionURL:null,country:{name:"Canada"}}},{id:"193533",title:"Dr.",name:"Dia",surname:"Sanou",slug:"dia-sanou",fullName:"Dia Sanou",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"194425",title:"Dr.",name:"Alexandra",surname:"Gottardo",slug:"alexandra-gottardo",fullName:"Alexandra Gottardo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"194656",title:"Dr.",name:"Aline",surname:"Ferreira",slug:"aline-ferreira",fullName:"Aline Ferreira",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"195044",title:"Dr.",name:"Joana",surname:"Neto",slug:"joana-neto",fullName:"Joana Neto",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"195045",title:"Ph.D.",name:"Eliany",surname:"Oliveira",slug:"eliany-oliveira",fullName:"Eliany Oliveira",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"open-access-funding-funders-list",title:"List of Funders by Country",intro:"
If your research is financed through any of the below-mentioned funders, please consult their Open Access policies or grant ‘terms and conditions’ to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
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IMPORTANT: You must be a member or grantee of the listed funders in order to apply for their Open Access publication funds. Do not attempt to contact the funders if this is not the case.
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UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
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The equipment required to perform the distillation process is known as distillation column. Since initial investment and maintenance costs for distillation columns are very high it is necessary to have an appropriate mathematical model that allows improving the comprehension of the column dynamics, especially its thermal behaviour, in order to enhance the control and safety of the process. This chapter presents a general panorama of the mathematical modelling of distillation columns, having as a specific case of study the comparison of a space-state non-linear model and a Takagi-Sugeno fuzzy model for a batch distillation column using a binary mixture (Ethanol-Water).",book:{id:"5452",slug:"distillation-innovative-applications-and-modeling",title:"Distillation",fullTitle:"Distillation - Innovative Applications and Modeling"},signatures:"Adriana del Carmen Téllez-Anguiano, Mario Heras-Cervantes, Juan\nAnzurez-Marín, Gerardo Marx Chávez-Campos and José Antonio\nGutiérrez Gnecchi",authors:[{id:"12387",title:"Dr.",name:"Jose Antonio",middleName:null,surname:"Gutierrez Gnecchi",slug:"jose-antonio-gutierrez-gnecchi",fullName:"Jose Antonio Gutierrez Gnecchi"},{id:"189166",title:"Dr.",name:"Adriana",middleName:null,surname:"Téllez-Anguiano",slug:"adriana-tellez-anguiano",fullName:"Adriana Téllez-Anguiano"},{id:"194844",title:"MSc.",name:"Mario",middleName:null,surname:"Heras-Cervantes",slug:"mario-heras-cervantes",fullName:"Mario Heras-Cervantes"},{id:"194845",title:"Dr.",name:"Juan",middleName:null,surname:"Anzurez-Marín",slug:"juan-anzurez-marin",fullName:"Juan Anzurez-Marín"},{id:"194846",title:"Dr.",name:"Gerardo",middleName:"Marx",surname:"Chávez-Campos",slug:"gerardo-chavez-campos",fullName:"Gerardo Chávez-Campos"}]},{id:"54078",title:"Distillation Techniques in the Fruit Spirits Production",slug:"distillation-techniques-in-the-fruit-spirits-production",totalDownloads:4985,totalCrossrefCites:15,totalDimensionsCites:26,abstract:"During the distillation of the fermented fruit mash or juice, ethanol and water are the carriers of a huge number of the other volatile aroma compounds. Unique and distinctive flavour of the final spirits depends on their quantity and quality. Fruit spirits have higher concentration of almost all types of volatile compounds with comparing to other types of distilled spirits. The art of distillation run is to obtain the best balance between congeners present. Two different types of distillation equipment are used for the production of fruit spirits: copper Charentais alembic and batch distillation columns. Although both distillation methods are based on the same theoretical principles, a different quantity of the flavour compounds of the final spirits is produced by using different distillation equipment. The main difference was shown in different distributions of the methanol, n-propanol, higher alcohols and fatty acid esters. Distillation methods need to be adjusted for each fruit spirits regardless to distillation equipment employed because fermented mash of different fruit varieties has a different requirement for distilling. Alembic stills yield better aroma and more characteristic fruit distillates but are slow and require more labour. Column still cleans the distillate giving a decent aroma and higher concentration of alcohol.",book:{id:"5452",slug:"distillation-innovative-applications-and-modeling",title:"Distillation",fullTitle:"Distillation - Innovative Applications and Modeling"},signatures:"Nermina Spaho",authors:[{id:"189124",title:"Associate Prof.",name:"Nermina",middleName:null,surname:"Spaho",slug:"nermina-spaho",fullName:"Nermina Spaho"}]},{id:"54676",title:"Fractional Distillation of Organic Liquid Compounds Produced by Catalytic Cracking of Fats, Oils, and Grease",slug:"fractional-distillation-of-organic-liquid-compounds-produced-by-catalytic-cracking-of-fats-oils-and-",totalDownloads:1749,totalCrossrefCites:0,totalDimensionsCites:2,abstract:"This work aims to investigate the fractional distillation of organic liquid products (OLP) obtained by catalytic cracking of palm oil (Elaeis guineensis Jacq.) at 450°C, 1.0 atm, with 5, 10, and 15% (wt) Na2CO3, using a stirred tank reactor of 143 L. The fractional distillations of OLP were carried out in laboratory scale with and without reflux using columns of different heights, and a pilot‐packed distillation column with internal reflux. OLP and distillation fractions (gasoline, kerosene, light diesel, and heavy diesel) were physicochemically characterized for density, kinematic viscosity, acid value, saponification value, refractive index, flash point, and copper strip corrosion. The OLP and light diesel fractions were analyzed by Fourier transform infrared spectroscopy (FT‐IR) and gas chromatography‐mass spectrometry (GC‐MS). For the experiments in laboratory scale, the yields of distillates decrease along with column height, with and without reflux, while those of bottoms products increase. The yields of distillates and gas increase with increasing Na2CO3 content, while those of bottoms products decrease. The densities of gasoline, kerosene, and light diesel produced in laboratory scale with reflux superpose exactly those of kerosene, light diesel, and heavy diesel produced in laboratory scale without reflux. The kinematic viscosity decreases with increasing column height for the experiments in laboratory scale. The acid values of distillation fractions decrease along with the column height for the experiments with and without reflux. The FT‐IR of distillation fractions in pilot and laboratory scales identified the presence of aliphatic hydrocarbons and oxygenates. The GC‐MS analysis identified OLP composition of 92.84% (area) hydrocarbons and 7.16% (area) oxygenates. The light diesel fraction contains 100% hydrocarbons with an acid value of 0.34 mg KOH/g, proving the technical feasibility of OLP de‐acidification by the fractional distillation process.",book:{id:"5452",slug:"distillation-innovative-applications-and-modeling",title:"Distillation",fullTitle:"Distillation - Innovative Applications and Modeling"},signatures:"C. C. Fereira, E. C. Costa, D. A. R. de Castro, M. S. Pereira, A. A.\nMâncio, M. C. Santos, D. E. L. Lhamas, S. A. P. da Mota, M. E. Araújo,\nLuiz E. P. Borges and N. T. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. 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