Staphylococcus aureus is a microorganism of great health risk because of its high resistance to antibiotics. Methicillin-resistant strains (MRSA) are most at risk, especially in hospital patients and children. In recent years, it has been shown that a combination therapy of two or more drugs is more effective than monotherapy traditional. Furthermore, it has also been seen that many natural substances and plant extracts can inhibit the MRSA growth and other microorganisms. However, little has been studied about the combinations of different extracts or extracts combination with other commonly used drugs. The purpose of this work was to evaluate of extracts of propolis with garlic, oregano and ciprofloxacin to inhibit growth of MRSA strains, using isobolographic method. The results showed that combinations of garlic with propolis inhibit the growth of MRSA, but only in small concentrations. High concentrations of these two extracts appear to have an antagonistic effect. Combinations of propolis and oregano show a synergistic effect at any concentration. Finally, the combination of propolis with ciprofloxacin has an antagonistic effect. The action of ciprofloxacin is decreased when was combined with propolis. Health professionals should know this to warn patients when they use a natural resource, especially if a drug is being administered.
Part of the book: Active Ingredients from Aromatic and Medicinal Plants