Genetic mutations associated with RE/ARE spectrum.
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More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"stanford-university-identifies-top-2-scientists-over-1-000-are-intechopen-authors-and-editors-20210122",title:"Stanford University Identifies Top 2% Scientists, Over 1,000 are IntechOpen Authors and Editors"},{slug:"intechopen-authors-included-in-the-highly-cited-researchers-list-for-2020-20210121",title:"IntechOpen Authors Included in the Highly Cited Researchers List for 2020"},{slug:"intechopen-maintains-position-as-the-world-s-largest-oa-book-publisher-20201218",title:"IntechOpen Maintains Position as the World’s Largest OA Book Publisher"},{slug:"all-intechopen-books-available-on-perlego-20201215",title:"All IntechOpen Books Available on Perlego"},{slug:"oiv-awards-recognizes-intechopen-s-editors-20201127",title:"OIV Awards Recognizes IntechOpen's Editors"},{slug:"intechopen-joins-crossref-s-initiative-for-open-abstracts-i4oa-to-boost-the-discovery-of-research-20201005",title:"IntechOpen joins Crossref's Initiative for Open Abstracts (I4OA) to Boost the Discovery of Research"},{slug:"intechopen-hits-milestone-5-000-open-access-books-published-20200908",title:"IntechOpen hits milestone: 5,000 Open Access books published!"},{slug:"intechopen-books-hosted-on-the-mathworks-book-program-20200819",title:"IntechOpen Books Hosted on the MathWorks Book Program"}]},book:{item:{type:"book",id:"3302",leadTitle:null,fullTitle:"New Research Directions in DNA Repair",title:"New Research Directions in DNA Repair",subtitle:null,reviewType:"peer-reviewed",abstract:"This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.",isbn:null,printIsbn:"978-953-51-1114-6",pdfIsbn:"978-953-51-5375-7",doi:"10.5772/46014",price:159,priceEur:175,priceUsd:205,slug:"new-research-directions-in-dna-repair",numberOfPages:674,isOpenForSubmission:!1,isInWos:1,hash:"1370d613ce38c993753a3dd25f102a3c",bookSignature:"Clark Chen",publishedDate:"May 22nd 2013",coverURL:"https://cdn.intechopen.com/books/images_new/3302.jpg",numberOfDownloads:47217,numberOfWosCitations:63,numberOfCrossrefCitations:44,numberOfDimensionsCitations:98,hasAltmetrics:1,numberOfTotalCitations:205,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 17th 2012",dateEndSecondStepPublish:"May 8th 2012",dateEndThirdStepPublish:"August 12th 2012",dateEndFourthStepPublish:"November 10th 2012",dateEndFifthStepPublish:"December 10th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,editors:[{id:"62462",title:"Prof.",name:"Clark",middleName:null,surname:"Chen",slug:"clark-chen",fullName:"Clark Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/62462/images/1731_n.jpg",biography:"Dr. Clark C. Chen received his B.S. from Stanford University in 1992, M.S. from Columbia University in 1993, and his M.D.-Ph.D. from Harvard Medical School in 2001. He completed his neurosurgery training at the Massachusetts General Hospital and subsequently completed independent fellowships in stereotactic neurosurgery and radiosurgery. Dr. Chen previously served as the director of Clinical Neuro-Oncology at the Beth Israel Deaconess Medical Center before his current role as the Director of Stereotactic and Radiosurgery and Co-Director of Surgical Neuro-Oncology at the University of California, San Diego. Dr. Chen’s research is directed at identifying alterations in DNA repair pathways as they relate to brain cancer therapy. Dr. Chen is the recipient of the Damon Runyon Fellowship Award, the James Kerr Award, American Brain Tumor Association Investigator Award, Paul Calabresi Scholar Award, Burroughs Wellcome Career Award, William Guy Forbeck Scholar Award, the Doris Duke Clinical Scientist Award and the Kimmel Scholar Award.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"University of California, San Diego",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"421",title:"Molecular Genetics",slug:"biochemistry-genetics-and-molecular-biology-microbiology-molecular-genetics"}],chapters:[{id:"44542",title:"Recombination Hot-Spots and Defense Players – Maintenance of Genomic Integrity",doi:"10.5772/54016",slug:"recombination-hot-spots-and-defense-players-maintenance-of-genomic-integrity",totalDownloads:1586,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Radhika Pankaj Kamdar and Basuthkar J. 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Behar, Ch. Kabakchiev, I. Garvanov and H. Rohling",authors:[{id:"2768",title:"Dr.",name:"Christo",middleName:null,surname:"Kabakchiev",fullName:"Christo Kabakchiev",slug:"christo-kabakchiev"},{id:"18669",title:"Dr.",name:"Vera",middleName:null,surname:"Behar",fullName:"Vera Behar",slug:"vera-behar"},{id:"18671",title:"Dr.",name:"Ivan",middleName:null,surname:"Garvanov",fullName:"Ivan Garvanov",slug:"ivan-garvanov"},{id:"18672",title:"Prof.",name:"Hermann",middleName:null,surname:"Rohling",fullName:"Hermann Rohling",slug:"hermann-rohling"}]},{id:"14034",title:"Practical Monte Carlo Based Reliability Analysis and Design Methods for Geotechnical Problems",slug:"practical-monte-carlo-based-reliability-analysis-and-design-methods-for-geotechnical-problems",signatures:"Jianye Ching",authors:[{id:"19783",title:"Prof.",name:"Jianye",middleName:null,surname:"Ching",fullName:"Jianye Ching",slug:"jianye-ching"}]},{id:"14035",title:"A Monte Carlo Framework to Simulate Multicomponent Droplet Growth by Stochastic Coalescence",slug:"a-monte-carlo-framework-to-simulate-multicomponent-droplet-growth-by-stochastic-coalescence",signatures:"Lester Alfonso, Graciela Raga and Darrel Baumgardner",authors:[{id:"18046",title:"Prof.",name:"Lester",middleName:null,surname:"Alfonso",fullName:"Lester Alfonso",slug:"lester-alfonso"},{id:"22501",title:"Dr.",name:"Graciela",middleName:null,surname:"Raga",fullName:"Graciela Raga",slug:"graciela-raga"},{id:"22502",title:"Dr.",name:"Darrel",middleName:null,surname:"Baumgardner",fullName:"Darrel Baumgardner",slug:"darrel-baumgardner"}]},{id:"14036",title:"Monte Carlo Simulation of Room Temperature Ballistic Nanodevices",slug:"monte-carlo-simulation-of-room-temperature-ballistic-nanodevices",signatures:"Ignacio Íñiguez-de-la-Torre, Tomás González, Helena Rodilla, Beatriz G. 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Arif",authors:[{id:"21687",title:"Dr.",name:"Sayyad Zahid",middleName:null,surname:"Qamar",fullName:"Sayyad Zahid Qamar",slug:"sayyad-zahid-qamar"},{id:"21688",title:"Prof.",name:"Anwar Khalil",middleName:null,surname:"Sheikh",fullName:"Anwar Khalil Sheikh",slug:"anwar-khalil-sheikh"},{id:"21689",title:"Prof.",name:"Abul Fazal M.",middleName:null,surname:"Arif",fullName:"Abul Fazal M. Arif",slug:"abul-fazal-m.-arif"},{id:"21690",title:"Prof.",name:"Tasneem",middleName:null,surname:"Pervez",fullName:"Tasneem Pervez",slug:"tasneem-pervez"}]},{id:"14041",title:"Loss of Load Expectation Assessment in Electricity Markets using Monte Carlo Simulation and Neuro-Fuzzy Systems",slug:"loss-of-load-expectation-assessment-in-electricity-markets-using-monte-carlo-simulation-and-neuro-fu",signatures:"H. 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Geisler",authors:[{id:"19631",title:"Dr.",name:"Benjamin",middleName:"Peter",surname:"Geisler",fullName:"Benjamin Geisler",slug:"benjamin-geisler"}]},{id:"14043",title:"Monte Carlo Simulations of Adsorbed Molecules on Ionic Surfaces",slug:"monte-carlo-simulations-of-adsorbed-molecules-on-ionic-surfaces",signatures:"Abdulwahab Khalil Sallabi",authors:[{id:"22986",title:"Prof.",name:"A",middleName:null,surname:"Slabi",fullName:"A Slabi",slug:"a-slabi"}]}]}]},onlineFirst:{chapter:{type:"chapter",id:"75338",title:"Rolandic Epilepsy: Self-Limited Epilepsy with Centrotemporal Spikes",doi:"10.5772/intechopen.96148",slug:"rolandic-epilepsy-self-limited-epilepsy-with-centrotemporal-spikes",body:'
Self-limited epilepsy with centrotemporal spikes (SECTS), well-known as Rolandic epilepsy is the most frequent among the childhood focal epilepsies and may account for about 15–25% of all epileptic syndromes diagnosed between the ages of 5 to 15 years [1]. It is termed ‘rolandic’ epilepsy because the focal seizures are originated from the region around the lower part of the central gyrus of Rolando. The incidence range changes between 7.1–21 per 100000 in a population younger than 15 years with male predominance [2]. The age of onset in 90% of cases between 1 and 10 years with a peak around 6–7 years and recovery occurs before the age of 15–16 years [2, 3, 4].
Self-limited epilepsy with centrotemporal spikes is a syndrome of brief hemifacial motor seizures, frequently having associated somatosensory symptoms, usually without impairment of consciousness which tend to evolve into GTCS [3, 4, 5, 6]. Seizures are often related to sleep [7]. Genetic predisposition is frequent, and there is male predominance [3, 5, 8, 9]. An interictal EEG has normal background activity with biphasic high-voltage centrotemporal spikes, often followed by slow waves that are activated by sleep and tend to spread or shift from side to side [10]. Neurological and mental status before the debut of epilepsy is normal. There are no specific abnormalities on brain MRI or CT. Many studies reported that RE may cause transient or long-lasting cognitive and behavioral disturbances [4, 5, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40].
Panayiotopoulos described a concept of benign childhood susceptibility syndrome (BCSSS) to unify RE, Panayiotopoulos syndrome (PS) and childhood occipital epilepsy of Gastaut (ICOE-G) outlined the common features, course of diseases, prognosis, and the possible genetic predisposition in this group of associated syndromes [5].
1989 ILAE classification recognized three “age-related and localization-related epilepsies and syndromes”: (1) benign childhood epilepsy with centrotemporal spikes (BCECTS); (2) childhood epilepsy with occipital paroxysms; (3) primary reading epilepsy [10].
ILAE Commission on Classification and Terminology lists three childhood idiopathic focal epilepsy syndromes: (1) benign childhood epilepsy with centrotemporal spikes (BCECTS); (2) Panayiotopoulos syndrome, and (3) late-onset childhood occipital epilepsy (Gastaut type) [13].
Rolandic epilepsy had undergone significant terminological and classification changes. RE had been previously considered as benign childhood epilepsy. Frequently reported cognitive and language impairments and behavioral disturbances in children with RE led to the replacement of the terms “benign” and “idiopathic” by the “self-limited” in the new classification proposed by Sheffer I. and colleagues [41].
The role of genetic factors in RE has been presumed since the first high incidence of centrotemporal spikes in family members of patients with RE was reported in 1964 [42]. RE and related syndromes with atypical features do not follow a Mendelian inheritance mode [43]. The clinical and genetic studies have shown complex inheritance [43, 44, 45, 46, 47, 48, 49, 50, 51].
The genetics of CTS is not the same as the clinical genetics of RE [52]. Although CTS is the primary EEG characteristics of RE or ARE, they are also observed in healthy children [53] or the children with autistic spectrum disorders without seizures [54]. Only 10% of EEG trait carriers had seizures [55, 56]. An autosomal dominant mode of inheritance of CTS on EEG has been reported by several authors [42, 55, 56] but it is still debated [52]. The linkage of CTS to ELP4-PAX6 region on 11p13 and chromosome 15q13 [57], 16p12–11.2 [58], and 15q14 [59] have been identified.
Doose et al. investigated the broad spectrum clinical and EEG manifestation of 147 children with RE and their 1266 family members revealed a high incidence of febrile convulsion and afebrile GTCS in patients and their relatives suggested multifactorial inheritance. EEG recordings of probands and their siblings showed a high rate of generalized EEG traits [43].
A multicentral twin study of eighteen twin pairs (10 MZ, 8 DZ) based on a twin database done by Vadlamudi and colleagues demonstrated that the etiology of RE and its inheritance mode is much more complicated than considered before [44].No twin pairs were concordant for RE. Only one monozygotic twin pair has shown centrotemporal spikes on EEG without seizures. Another intriguing finding from this twin data was that all twin pairs with atypical features RE, had a co-twin with seizures although discordant for RE, which emphasized that genetic factors may be more important in atypical cases of RE.
The genetic basis of RE/ARE is polygenic and complex, the interaction of environmental factors or other genes should be considered in etiology of RE spectrum epilepsy syndromes [60, 61]. A number of genes were found to follow the Mendelian inheritance and be associated with RE/ARE (Table 1).
Mutations | Protein function | Special features | Reports |
---|---|---|---|
KCNQ2/KCNQ3 | Voltage-gated potassium channel | BFNS plus RE | Maihara et al. [62] |
BFNS CTS trait | Coppola et al. [63] | ||
BFNS plus RE, RE, CTS trait | Neubauer et al. [64] | ||
SRPX2 | E2A/HLF fusion | RS, oral and speech dyspraxia, MR | Roll et al. [65] |
ELP4 | Elongator subunit | CTS trait, speech disorder, behavior disturbances, ADHD | Strug et al. [57] |
GRIN2A | NMDAR subunit | Atypical RE (LKS/CSWS), intellectual disability, various dysmorphic features | Lemke et al. [66] |
RBFXO1/3 | ATAXIN 2-BINDING PROTEIN 1/HEXARIBONUCLEOTIDE-BINDING PROTEIN 3 | RE, atypical RE, CTS trait | Lal et al. [67] |
DEPDC5 | GATOR complex | RE, atypical RE | Lal et al. [50] |
GABRG2 | GABA receptors | RE, atypical RE | Reinthaler et al. [68] |
CAMK2A | Subunit of calcium/calmodulin-dependent protein kinase II | Atypical RE, intellectual disability and autism | Rudolf et al. [45] |
GRIN2B | NMDAR subunit | Atypical RE, epileptic encephalopathy, intellectual disability | Rudolf et al. [45] |
CHRNA4 | Neuronal nicotinic acetylcholine receptor α4 subunits | RE (familial case) | Neng et al. [69] |
Genetic mutations associated with RE/ARE spectrum.
Lemke et al., have identified GRIN2A mutations in 20% of patients with ARE associated with neurocognitive disturbances [66].
Although mutations in PRRT2, KCNQ2, KCNQ3, RBFOX1, and DEPDC5 genes with an autosomal dominant transmission reported in patients with RE spectrum epilepsy syndromes, they have not been confirmed by the studies based on large case series [70].
With the exception of GRIN2A and ELP4, many genes currently associated with RE/ARE, including KCNQ2, KCNQ3, CHRNA4, DEPDC5, RBFOX1/3, BDNF, and GABAA-R, were initially linked to other neurogenetic conditions, and later their phenotypes were expanded to RE/ARE.
The main seizure type in RE according to the ILAE 2017 seizure classification is focal aware seizure consisting of motor-hemifacial tonic or clonic contractions, oro-pharyngo-laryngeal symptoms, sensory symptoms represented by unilateral numbness or paresthesia of tongue, lips, gum, and inner part of the check, and associated with speech arrest, hypersalivation, and focal to bilateral seizures [2, 3, 4, 41, 71]. Hemiconvulsions and bilateral tonic–clonic seizures are less frequently observed ictal features, mainly seen in younger children due to rapid distribution of focal onset seizures [2, 3, 4, 6]. Hemiconvulsions may be followed by post-ictal Todd’s hemiparesis in 10% of cases [8, 72].
Seizures are brief, usually last from 30 sec to 2–3 minutes or longer if turn into bilateral tonic–clonic seizures [6, 18, 72]. Seizures mainly occur during night sleep or drowsiness, whereas the probability of awake seizures is less than 10% [73, 74]. Seizure frequency is low, most patients have less than 10 seizures, 10%–20% of patients have a single seizure [75]. Consciousness is completely preserved in around 60% of patients with RE [5].
Focal motor seizures in approximately one-third of cases manifest as unilateral oral-facial tonic or clonic contractions. These are brief (few seconds −1 min), a sudden burst of clonic contractions of the face, which may be entirely localized in the lower lip or spread to the ipsilateral upper and very rare to the lower extremities [1, 2, 3, 4, 5, 71, 76].
Tonic deviation of the mouth is frequently observed ictal motor manifestation [5].
Oro-pharyngo-laryngeal symptoms are mostly motor ictal phenomena with the involvement of the (epi-) glottis and pharynx (> 50%) produce guttural bizarre sounds, resembling gargling, grunting, wheezing [72]. These may be accompanied by contractions of the respiratory and abdominal muscles (vomiting like contractions) which appear in more than half of seizures [77]. They consist of unilateral sensory and motor manifestations inside the mouth, tongue, inner cheek, gums, teeth, and pharyngolaryngeal regions [3].
Speech arrest occurs in >40% of seizures with dys - or anarthria [3, 72]. The child usually is aware, with preserved receptive language, attempts to communicate with gestures, but unable to produce a single intelligible word [3, 5]. Speech arrest is considered more as a motor ictal manifestation associated with the loss of the power and coordination for the articulation of words [3]. There is no impairment of the cortical language mechanisms [4, 5].
Focal non-motor seizures commonly observed in RE.
Sensory symptoms may manifest as unilateral numbness or paraesthesias like tingling, prickling, freezing and their variations in the parts (rarely involve the whole area) of oral-facial-pharyngeal area, usually tongue, inner cheek, gum, teeth, lips [3, 4, 6]. Sensory seizures often occur in combination with motor seizures and hypersalivation [3, 5, 72].
Hypersalivation is one of the most characteristic autonomic ictal symptoms of RE, occurs in one-third of cases [2, 3, 4, 5, 71]. It is frequently associated with hemifacial motor symptoms. As well as the awareness is not disturbed in most of the cases, children usually are able to describe their sensations as sudden filling of the mouth with saliva and air, difficulty in pronouncing words, a lot of saliva flowing from the mouth [5].
Other autonomic ictal manifestations as ictal emesis and ictal syncope may observe rarely in RE. Although autonomic seizures are the cardinal symptom of Panayiotopoulos syndrome, they are reported in RE [74, 78, 79, 80, 81, 82]. The overlap of the clinical and EEG features of PS and RE has been widely investigated by several authors [5, 74, 79, 80]. The cases where two different types of childhood focal seizures presented at the same time or one form of epilepsy progressed to another have been thoroughly reported by different investigators [74, 79, 80, 81, 82, 83, 84, 85].
Focal to bilateral tonic–clonic seizures are a frequent seizure type present in one to two-thirds of children with RE. FBTCSs mostly appear during night sleep [86].
Status epilepticus is seen rarely and usually associated with an atypical course of the disease [87].
Focal motor SE occurs more often than generalized convulsive SE [3]. This state consists of unilateral or bilateral hemifacial contraction, subtle perioral myoclonus, speech arrest, dysarthria, excessive drooling, swallowing difficulties [88, 89, 90, 91, 92, 93].
The EEG picture is distinctive in Rolandic epilepsy. The background activity is almost always preserved in an awake state and during sleep [91]. The characteristic interictal EEG pattern- centrotemporal spikes (CTS) or rolandic spikes are regarded as the neurobiological markers of RE. CTS is high-amplitude (usually > than 150 mkV) biphasic spikes or sharp waves of ∼ 70–80 milliseconds duration frequently followed by a slow activity on the central-mid temporal region (C3/C4, T3/T4) [2, 3, 4]. More posterior localization of CTS is often observed in the youngest patients [94]. The spikes may occur isolated or in clusters, in one or both hemispheres [95, 96] (Figure 1A and B). A focal rhythmic slow activity over the centrotemporal region is occasionally observed [2]. The most typical finding of the rolandic spikes is their significant increase in frequency during NREM sleep [74] (Figure 1C-E). The spikes appear only in sleep in about a third of children [97].
7y.old boy with rolandic epilepsy. (A) Interictal awake EEG. Left centrotemporal spikes with rapid spreading to the right frontal-anterior temporal region. with maximum negativity over the C3T3,F7 and maximum positivity on the right-midline frontal-parietal region F4Fp2FzPzCz(AV montage, sensitivity 20Mkv/mm, paper speed 30mm/sec, LFF 70 Hz, HFF 0.5 Hz, Rejector 50 Hz). (B) Increased paper speed clearly demonstrates propagation of left centrotemporal spikes to the right frontal-anterior temporal region (AV montage, sensitivity 20 Mkv/mm, paper speed 120 mm/sec, LFF 70 Hz, HFF 0.5 Hz, Rejector 50 Hz). (C and D) Interictal 1NREM sleep EEG. The frequency of CTS of the same distribution is increased. (E) The same EEG sample in bipolar longitudinal montage demonstrates phase reversal on both right and left centrotemporal region (C3C4T3T4).
EEG and magnetoencephalography (MEG) studies show a stable horizontal dipole coming from the lower rolandic region with maximal electronegativity in the centrotemporal region and electropositivity in the frontal region, usually seen unilateral or bilateral [98, 99, 100]. Spikes may often appear in the central, parietal, midline, or even occipital regions which do not exclude a diagnosis of RE [98].
Somatosensory stimulation by the tapping of hands or feet or electrical stimulation of fingers at 1 Hz may activate CTS and somatosensory evoked potentials (SEPs) on the contralateral hemisphere [101].
Brief interictal generalized bursts of 3–5 Hz slow waves with intermixed small spikes distinctive than a pattern 3 Hz spike–wave seen in CAE may observe in about 4% of patients with RE [85, 102].
Many studies have tried to identify the source of rolandic discharges using topographic analysis, source modeling techniques, dipole tracing method, magnetoencephalography (MEG), and functional MRI (fMRI) investigations [99, 100, 101, 103, 104, 105, 106]. The functional MRI (fMRI) triggered by EEG of the rolandic spikes as well as MEG showed activation of the sensorimotor area [104], mainly in the orofacial division of the primary sensorimotor cortex [105]. However, it is challenging to distinguish the precentral or postcentral origin of CTS [103]. Ishitobi et al., suggested the precentral origin of rolandic spikes explained this theory by the continuity of cortical surface polarity from negative gyral cortex to the surface positive interhemispheric fissure based on the combination of scalp EEG and MEG [103]. Gregory and Wong analyzed 12 independent foci in 10 patients with RE assumed that the generator of a dipole discharge was located halfway between the maximum negative and positive poles, and was most likely situated at the depth of the lower rolandic fissure or Sylvian fissure [107]. The propagation pattern of rolandic spikes first studied by Jung et al., suggests that spike propagation was caused by intracortical spreading a single dipole across the central sulcus [108].
CTS are diagnostic markers of RE only in a suggestive clinical presentation [74]. It has been widely reported that 1.2 to 3.5% of normal healthy children population between 5 and 12 years old [109, 110], 6–34% of siblings and relatives of patients affected by RE [9, 111, 112], children with migraine, behavior disturbances, ADHD, variety of organic brain diseases with or without seizures, such as cerebral tumors, Rett syndrome, fragile X syndrome and focal cortical dysplasia [84, 113] also show CTS in routine EEG recording.
The first described ictal patterns are characterized by a quite monomorphic sequence of rhythmic sharp waves or spikes without significant post-ictal slowing [91, 114]. In 1990, Gutierrez et al. described an ictal event with speech arrest only characterized by a short train of ictal alpha activity, and then two multiple spikes and wave complexes originated from the left centrotemporal region followed by marked attenuation of the left hemispheric background [115]. Subclinical rhythmic discharges of spike and wave in the centrotemporal region have been documented by several authors in RE [116, 117]. Saint-Martin et al. in 2001 described a series of patients presenting with typical and also atypical ictal manifestations such as falls, negative myoclonus and observed that positive motor phenomenon correlated to the spike component preceding a negative motor phenomenon, correlated with the slow-wave component of the spike and wave complex [118].
Capovilla et al. recorded 34 seizures in 30 patients with RE and described four electrographic seizure patterns thus emphasizing that ictal pattern for RE is not unique [116]:
low-voltage activity of fast rhythmic spikes, increasing in amplitude and decreasing in frequency observed in the majority of patients,
a discharge of spikes intermixed with sharp waves increasing in frequency and amplitude,
monomorphic theta which progressively formed a discharge increasing in amplitude and decreasing in frequency,
initial focal depression of the electrical activity, followed by one of the three above described patterns.
Ictal EEG source analysis of 3 patients with RE demonstrated the activation of the opercula-insular area, time-locked to the contralateral focal myoclonic jerks [119].
In most cases, children with RE have a good prognosis regarding both seizures and neurodevelopment [120, 121]. The remission of seizures usually occurs before the age of 18 years [11, 98]. The cognitive and behavior problem may happen in an active period of disease which is reversible in most patients [11, 12].
Rolandic seizures occur in a period of significant brain maturation. The dysfunction of neuronal network activities such as focal discharges may be associated with neuropsychological problems, including, linguistic, cognitive, and behavioral impairment [28, 29, 30, 122]. The frequent spike discharges in sleep may boost language and attention processing problems [120, 123, 124, 125].
Mood and behavioral disorders were present in nearly a third of children (30.9%) with RE [126, 127, 128]. Retrospective studies have proposed that early age at onset pretends a more aggressive seizure course [18, 129, 130, 131].
Functional MRI study revealed CTS density caused hemodynamic changes even during wakefulness can interfere with the normal brain-language network and the bilateral insular cortex [132].
The neuropsychological tests such as Wechsler Intelligence Scale for Children-III (WISC-3rd), verbal fluency test, Wisconsin card sorting test, attention deficit diagnostic scale, and child behavior checklist scale are usually administered to measure a wide range of skills and cognitive functions of RE patients [35, 36, 37, 38, 133].
Many researchers showed a variety of neuropsychological deficits, behavioral and emotional difficulties in a limited cohort of patients with RE range from 19 to 67% [22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 134, 135]. The series of reported children with uncomplicated RE were described lower average results on neuropsychological tests involving visuomotor coordination, some executive functions, sustained attention, and language issues like spelling, reading aloud, reading comprehension, memory, and learning of auditory–verbal material, delayed recall, and verbal fluency, compared with controls. However, the Full-Scale Intelligence Quotient (FSIQ) was not significantly low in most of them.
D’Alessandro et al. investigated the neuropsychological data of 44 children with RE who did not have a seizure for more than 6 months without treatment. Attention, language, and visuomotor coordination tasks problems were more severe in children with a bilateral epileptiform discharge. However, in a follow-up assessment for 4 years, a re-examination of 11 children had revealed the normalization of cognitive functions in all [21].
Several studies reported that cognitive abnormalities and behavioral impairments are associated with a high interictal spike frequency [24, 25, 35, 120], the number of interictal abnormalities in wake or sleep [136], activation of interictal spikes during sleep [118, 137], and the presence of non-tangential dipole spikes [73].
Piccinelli et al. [138], investigated the frequency of specific learning disabilities such as reading, writing, and calculation in patients with typical RE and possible related electroclinical findings. They reported children with RE who developed seizures before age 8 years and had epileptiform discharges more than 50% of the sleep EEG recording in several tracings over more than a year were at risk of developing academic difficulties [138].
EEG may predict educational and behavioral impairments in children with RE. The presence of an intermittent slow-wave focus during wakefulness, a high number of spikes in the first hour of sleep (and during whole night sleep), and multiple asynchronous bilateral spike–wave foci in the first hour of sleep are associated with learning problems in children with RE [16, 139].
RE can present or evolve to an atypical form, characterized by atypical ictal semiology, different EEG findings, and poor neuropsychological outcomes [19, 140, 141].
Massa et al. described 5 interictal EEG patterns that significantly correlated with atypical evolutions of RE: [41] intermittent slow-wave focus; [2] multiple asynchronous spike–wave foci; [3] long spike–wave clusters; [4] generalized 3-c/s “absence-like” spike–wave discharges; [1] conjunction of interictal paroxysms with negative or positive myoclonia, and abundance of interictal abnormalities during wakefulness and sleep [136].
Several studies have shown an association between atypical rolandic epilepsy and known genes (Table 1). The identification of de novo or inherited mutations of N-methyl-D-aspartate (NMDA) receptor subunit-encoding genes (GRIN2A and GRIN2B) linked to speech and language, cognitive impairment, and behavioral difficulties have been a significant breakthrough in the understanding of the nature of atypical RE [142, 143, 144, 145]. Another relevant gene is elongation factor protein 4 (ELP4), which is associated with language impairment, autism spectrum disorder, mental retardation, and epilepsy with centrotemporal spikes on EEG [146].
Atypical rolandic epilepsy (ARE) is a severe epileptic condition especially with regards to cognitive consequences. The first description of atypical features of RE was published by Aicardi & Chevrie in 1982 showed rolandic epilepsy presenting periods with new types of seizures, mainly atonic and myoclonic, associated with continuous spike-and-waves in slow-sleep EEG (CSWS/ESES), and transitory learning difficulties [147]. Doose and Baier described similar patients with atonic fits leading to daily falls which is the hallmark seizure type for Lennox–Gastaut syndrome and termed the condition “pseudo-Lennox syndrome” to differentiate this two distinct conditions [148]. Patients with ARE have significantly lower full-scale and verbal IQ than the patients with typical RE [149]. Neuropsychological impairment, which may sometimes be present before the onset of the disease, is constantly present during the clinical course, but in contrast to ESES and LKS, the cognitive outcome is always favorable [92, 150]. Clinical semiology consists of typical for RE focal seizures, generalized tonic–clonic seizures, atypical absences, myoclonic seizures, and atonic seizures. The atonic attacks may involve the whole axial musculature or be localized, causing repeated brief (0.5–2.0 s) atonic episodes in the head or a limb (epileptic negative myoclonus) that usually occur for periods lasting one to several weeks, separated by seizure-free intervals of weeks or months [6, 90, 92]. Such atonic attacks are associated with the slow-wave component of spike and wave complexes, and the location of the EEG discharges corresponds to that of the atonic episodes [151, 152]. Interictal awake EEG shows bilateral sharp and sharp-slow wave complexes with higher amplitude in the rolandic area, which increases during sleep with bilateral synchronization [90, 92, 116, 153].
Using carbamazepine may promote the diffusion of spike–wave activity from the rolandic focus to induce atonic seizures, atypical absences in patients with RE [154].
Rolandic status epilepticus refers to status epilepticus that can be convulsive or non-convulsive, and either generalized or focal lasting days or weeks including motor facial seizures, oromotor dyspraxia, anarthria with persistent drooling and swallowing problems [155]. The interictal EEG usually shows focally or bilaterally synchronous sharp waves or sharp and slow wave complexes predominant in the rolandic area with a tendency to become continuous during sleep [146, 155]. The condition can be resolved with a good neurocognitive outcome with appropriate treatment [146]. These seizures can persist for more than 1 month without treatment [156, 157].
The decision whether to treat children with RE or not requires a particularly careful risk–benefit analysis [2, 158, 159, 160, 161, 162, 163]. Many authors suggest that drug treatment is not necessary for typical RE because of its good prognosis, and usually infrequent nocturnal seizures [114, 154]. Moreover, in 40–50% of cases, the seizures are difficult to control with drugs [148]. Besides, the treatment with AED usually does not influence the duration of active epilepsy [163].
However, treatment may be indicated in patients with frequently recurring daytime seizures, generalized tonic–clonic seizures, young age at onset [164], or when the ictal events are disruptive to the patient or family [161, 163]. Furthermore, the presence of cognitive and behavioral disturbances, either transitory or persistent has to be considered [2, 5, 91, 92]. There is no single solution supported by definitive evidence which AED is more effective in the treatment of RE.
Internationally, carbamazepine (CBZ 20-40 mg/kg/d [165]) and valproate (VPA 20-30 mg/kg/d [166]) are the most often prescribed AED for children newly diagnosed RE [167]. However, the possible worsening of EEG in rolandic epilepsy by some drugs and particularly by CBZ, increasing epileptiform abnormalities during sleep, and inducing epileptic negative myoclonus have been reported [154].
Sulthiame, levetiracetam, and gabapentin were studied in a randomized controlled trial [158, 159, 167, 168, 169]. Sulthiame administered varied between 3.1 and 5.7 mg/kg/day was effective in controlling seizures in children with RE [159].
A prospective, open-label, pilot trial evaluating the efficacy and tolerability of levetiracetam (LVT 20-30 mg/kg/d) or oxcarbazepine (OXC 20-35 mg/kg/d) as monotherapy in two parallel groups of newly diagnosed RE patients demonstrated effectiveness in controlling seizures a follow-up period up to 2 years [162].
A randomized controlled multicenter trial comparing the effects of either Levetiracetam or Sulthiame on EEG in RE showed a reduction of epileptiform discharges after 12 weeks of treatment [158]. Persistent epileptiform discharges after 12 weeks of treatment are associated with recurrent seizures [158].
When the presence of ESES associated or not with negative myoclonus, clinical status, or acquired aphasia is detected in children with RE, a change of antiepileptic drugs should be considered. Class IV studies suggest that sulthiame, benzodiazepines, ethosuximide, and, in most severe cases, corticosteroids might be useful [91, 92].
Duration of treatment in RE should not exceed 1 year following the last seizure, regardless of EEG changes [2].
We are grateful to Dr. Sándor Beniczky for his valuable comments on EEG figures.
None of the authors has any conflict of interest to disclose.
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