As a tenured faculty member, I am currently directing the Molecular Neurogenetic Diagnostic Laboratory and Heading the Developmental Genetics Laboratory at the New York State Institute for Basic Research in Developmental Disabilities. I am also the Founder Director of Peking University Center of Medical Genetics as well as the Founder Chairman of Dept. Medical Genetics of Peking University Health Science Center. I have a broad research interest in perinatal health, including maternal-fetal medicine with a focus on prematurity, children development, mental retardation, and developmental disabilities, and birth defects with a focus on brain developmental-relevant disorders. I have published 140+ articles in peer-reviewed journals, including Lancet, Nature Genetics, American Journal of Human Genetics, American Journal of Medical Genetics, Clinical Genetics, Human Genetics, Genetics in Medicine, Journal of Medical Genetics, Neurogenetics, Molecular Genetics, and Metabolism, Advanced Genetics, Genetic Testing, Neurology, Neurological Science, Biochimica et Biophysica Acta - Proteins & Proteomics, Biochemical and Biophysical Research Communications, Behavior and Brain Function, Encyclopedia, J Community Genetics, J Chromatogr B, J Mol Neurosci, BMC Preg Childbirth, and Epidemiology and Infection, etc. I have been the peer reviewer for the American Journal of Human Genetics, American Journal of Medical Genetics, Clinical Genetics, Nucleic Acid Research, Human Biology, FEBS Lett, Biochimica et Biophysica Acta, Encyclopedia of Medical Genomics and Proteomics, Genet Testing, Mol Biol Report, African J. Pathology, Fertility and Sterility, BMC Public Health, Clinical and Experimental Dermatology, PLoS One, Reproductive BioMedicine (Online) and Reproductive Biology. My research studies have been founded by the NIH (USA), March of Dimes Foundation (USA), Batten Disease Support and Research Association (USA), New York State Research Foundation for Mental Hygiene (USA), Chinese Ministry of Science and Technology (Oversea Chinese Outstanding Young Investigator Award, and 973 High Tech project), Chinese Ministry of Education (211, 985 Projects), Chinese Natural Science Foundation, and Shanghai Municipal Government. My current research is focusing on the genetic and genomic study of prematurity including preterm birth and stillbirth, as well as the outcome of pregnancy, with an integrated “-omics” approach. I am also exploring rational strategies for the prevention and intervention of preterm birth with a longitudinal approach. I have initiated China Human Placenta Project (CHPP) in 2015.