\r\n\tIn the last decades, particular attention to this field has been paid to the coastal erosion problem all over the world. Indeed, the deployment of artificial reservoirs, modification of the runoff characteristics of internal areas, sand extraction from rivers, and harbor siltation, caused a decrease of sediment input on the coastal environments, and, therefore, a generalized deficit in the sediment budget. Often, dredging activities are required to collect sediment finalized to “soft” techniques to restore beaches or to move the sand trapped in the harbor (clean or contaminated). \r\n\tMoreover, the coastal protections induced hydrodynamics and morphodynamics modifications inducing sometimes strong variations to the sediment transport regime.
\r\n
\r\n\tHistorically, all these aspects are related to specific research areas ranging from engineering, geology, geomorphology, biology, etc, but it is difficult to find a comprehensive overview of these topics.
\r\n
\r\n\tThis book is intended to collect original works and review concerning numerical and experimental investigation, theoretical works, methodological approaches, and any other technique that allow giving the actual state-of-the-art in the field of sediment transport.
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\n
1. Introduction
\n
Coastal erosion is a worldwide concern, affecting virtually all coastal countries. In some cases, erosion reaches stages where it results in a high rate of environmental degradation. The economic repercussions are diverse, such as damage to the natural environment and loss of public infrastructure and/or private property. These facts can have extremely serious consequences in economy, ecosystems, tourism, and public health.
\n
The main causes of coastal erosion are the rising of sea level that is underway globally and inadequate management of coastal areas. Frequently, it is associated with the installation of urban and industrial equipment or with structures dedicated to leisure, housing, and tourism.
\n
In the state of Ceará, Northeast Brazil, in the 1950s, an industrial harbor was built. The harbor structures, with other factors such as the destruction of dune bypass, produced a large erosive process downdrift. It was responsible for the loss of more than 400 m of beach in six decades. At Canoa Quebrada beach (a nationally and internationally famous touristic area), a recent partial process of collapse of the cliffs occurred as an answer to inappropriate uses and occupation. This fact produced landscape and economic damage. In the northern coast of Colombia, anthropogenic interruption of the longshore transport caused by the construction of groins, as well as some harbors, produced severe beach erosion along the downdrift shoreline.
\n
With the abrasive action of waves associated with rising sea level, these coastal areas in both countries are at risk of more substantial degradation. These environmental situations will be the object of synthetic technical and scientific analysis and discussion in this chapter. Mitigation propositions for both countries coastal areas are also considered.
\n
\n
\n
2. Methodology
\n
The data displayed are the result of bibliographic research, analysis of maps and satellite images, and fieldwork on the studied areas. In relation to Fortaleza, Brazil, data of direction and velocity of currents were also collected from the Brazilian Ministry of Navy. Data of bathymetry and sea level rise were digitized from the Brazilian navigation charts. Finally, measurements were made on satellite images on Google Earth, in order to define volumes of sediments available and accumulated on the shoreline. In relation to Canoa Quebrada beach, Brazil, topographic profiles covering a 300 m stretch were made in six distinct points, using a total station. High-resolution satellite images were analyzed in a 2004, 2008, and 2017 time series, in order to define the behavior of the cliff break line and determine its retreat speed. For the analysis and georeferencing of the images, the software QGIS, version 2.12, developed by the Open Source Geospatial Foundation—OSGeo, was used with DATUM SIRGAS 2000, projection UTM zone 24 S.
\n
For northern Colombia, beach profiles along 600 km and bathymetry survey were conducted. The beach profiles were made using a total station. The bathymetry survey (10 m water depth) was conducted using a precision echo sounder and a GPS (Global Positioning System) mounted on a vessel. The bathymetry beyond 10 m water depth was digitized from the south Caribbean navigation charts. A total of 270 sediment samples were also collected. The up-to-date nearshore bathymetry data were used in the modeling of nearshore wave field. Finally, time-series aerial photos available from Google Earth were analyzed to depict beach/dune changes at various locations.
\n
\n
\n
3. Environmental problems in the coast of Ceará State, Northeast of Brazil
\n
\n
3.1 Natural settings of the study area
\n
Ceará is one of the states of the Brazilian equatorial northeastern region. Its coastal area spans between the latitudes of 2o47′S and 4o50′S for 573 km and is characterized by long and gently sloping sandy beaches, irregularly interrupted by headlands, small estuaries with mangroves, sea cliffs, and beach rocks, with large dunes and small barrier islands [1, 2] (\nFigure 1\n).
\n
Figure 1.
Location and geological/geomorphological settings of Ceará state coastal area, northeast Brazil.
\n
The headlands are characterized, with few exceptions, by the occurrence of sea cliffs with heights varying from 2.7 to 20 m. Tertiary rocks are present, named Barreiras Formation, and create a low-lying tabular surface with less than 40 m in elevation, which extends from the shoreline up to 60 km inland. It outcrops as sea cliffs 3 to 15 m high [e.g., 3] (\nFigure 1\n).
\n
The mobile dunes orient E to W and are mostly barchans and transverse dune ridges [4, 5, 6, 7]. The rate of dune migration ranges from 9 m/y to 22 m/y, with an average of approximately 11 m/y [4, 5, 6, 7]. Frequently, the dunes bypass across the headlands, nourishing the beaches downdrift. This process is an important element of the sedimentological budget of this coastal area, considering that it counterbalances the downdrift erosion resulting from the impoundment of the longshore sand by the headlands.
\n
Climatic conditions are controlled by the ITCZ [8]. During fall, the ITCZ is at its southernmost position, resulting in the rainy season. After April, the ITCZ shifts northward, leading to the dry season [9]. The climate is tropical subhumid, with average precipitation between 1000 mm and 1420 mm/y [3]. Temperatures remain largely constant throughout the year, with monthly averages ranging between 25.5° and 27.5°C [10].
\n
The trade winds dominate the area and present a similar pattern to that of precipitation but with an opposite trend: As the precipitation rate decreases, the wind speed increases; during the wet season, the average wind speed is approximately half of that in the dry season. On average, maximum wind speed is around 8 m/s in the dry season. A particular characteristic of the wind condition is its constant easterly direction, coming from southeast or northeast [10].
\n
The predominant wave direction is 90°, with heights ranging from 1.0 to 1.5 m [4, 11]. The waves are mainly of the sea type, with occasional occurrence of NE swell [12]. The area is characteristic of a semidiurnal mesotidal regime with a spring tidal range of approximately 3.1 m [13]. The most referenced Holocene sea level curve [14] indicates +5 m at 5.1 Ky BP, followed by two rises and falls until the present level.
\n
A unique aspect of this stretch of coastal area is that it is not influenced by storm-induced surge and extreme wave conditions. Instead, extremely persistent unidirectional wind and wave forcing dominate, creating a strong and persistent longshore forcing that induces a large net rate of longshore sediment transport [15].
\n
The mean sea level rose 14 cm in the last 73 years, as seen in Fortaleza (for location, see \nFigure 1\n). The data was obtained by the analysis of the nautical maps of 1945 and 2018 of Fortaleza coast, taking into account the level of the sea in both years in each map [16]. It indicates that a rising of sea level is an important element of the present dynamics in the area.
\n
The rising of sea level, with inadequate and inappropriate uses, occupation, and development of the coast and of the shoreline, is producing large degradation of this coastal area, destroying ecosystems, construction, and equipment, thus causing economic, social, and environmental problems. The situation will be analyzed in two segments of the state coastal area, which are Mucuripe harbor headland, in Fortaleza city, and Canoa Quebrada beach, on the east coast (for location, see \nFigure 1\n).
\n
\n
\n
3.2 Coastal environmental problems in Fortaleza area
\n
The Mucuripe headland, in Fortaleza city, is characteristic of a low-lying (~1.5 in mean tide) outcrop of Precambrian quartzite (\nFigure 2A\n). It trends ESE-WNW and has been heavily engineered since the 1950s, following the installation of a harbor (\nFigure 2B\n).
\n
Figure 2.
(A) Mucuripe low-lying headland, in Fortaleza city, a natural feature that changes the orientation of the shoreline, from SE-NW to NE-SW. (B) The Mucuripe/Fortaleza harbor, installed in the 1950s, and the jetties built to protect the harbor’s basin from waves and silting. The jetties interrupted the longshore transport, which came from the east.
\n
The longshore current and transport of sand in the area take place from east to west. The sands, before the installation of the harbor, bypassed the headland and were transported to the west, nourishing the beaches downdrift, for dozens of kilometers. The two extensive jetties built to protect the harbor from waves and silting interrupted the longshore current, eliminating the transport of sediments downdrift [4, 12, 16, 17, 18]. Quantification of the sand intercepted by the headland and harbor structures yielded a reasonably accurate estimate of longshore sand transport rate of approximately 860,000 m3/y [12].
\n
This interruption of littoral drift induced a large accumulation of sand updrift, of the order of 825,000 m3/y [16, 19]. Since the installation of the harbor, the total amount of sand accumulated updrift is approximately 26.4 million m3, creating a new beach of 65.5 ha of area (Serviluz beach, for location, see \nFigure 2B\n) [16].
\n
However, part of the sand accumulated in Serviluz beach, despite the jetties, bypasses them and the headland, being transported around these features and deposited by wave diffraction along the northern side of the harbor, creating the Mansa Beach and silting the harbor’s basin (\nFigure 3\n). For this reason, dredging is frequently needed in the harbor basin, in order to let large boats dock without stranding. Surveys carried out by [16] indicated that the amount of sand dredged from the harbor’s basin since the 1950s is of the order of 21 million m3.
\n
Figure 3.
The residual bypass of sand across the jetties and the headland created the Mansa Beach and keep nourishing it regularly. The bypass also produces the silting of the harbor’s basin, which has to be frequently dredged.
\n
The aggressive interruption of the tremendous amount of net longshore sand transport has induced up to 100 m of beach erosion downdrift of the headland/harbor between 1960 and 1970 [17]. Numerous shoreline structures, such as groin fields, were constructed to protect the shoreline from this beach recession (\nFigure 4\n), further disrupting the longshore sand transport system and extending the artificial influence further downdrift [12, 17].
\n
Figure 4.
Jetties installed in Fortaleza coastal area, in order to protect the shoreline against the erosion resulted from the interruption of the longshore transport produced by the harbor and associated jetties constructed updrift (east of the shown area) (source: Google Earth, 2019).
\n
In addition to the blockage of longshore bypassing, the dune bypass is also completely obstructed by buildings densely constructed over the entire area during the last decades [4] (\nFigure 5\n). Practically no sand reaches the downdrift beach through headland dune migration anymore [4] or through the flux of the Ceará river mouth, to where the dunes of the western segment of Fortaleza city migrated before [16] (for location of Ceará river estuary, see \nFigure 4\n).
\n
Figure 5.
(A). East coast of Fortaleza city and Mucuripe harbor vicinity, with large dunefields. The red arrow shows the area where the bypass of dunes still took place after the construction of the harbor. (B). Complete urbanization of the dunefields, with cessation of dunes bypass.
\n
The consequences of these processes in the coastal dynamics are dramatic. The shoreline retracted some 400 m in 60 years at places 15 km from the headland [4, 13]. The erosion is still happening: In Icarai Beach, 25 km downdrift, beach recession of magnitude of 100 m took place between the years 2004 and 2016 [4].
\n
The retraction of the beaches indicates that the coastal dynamics in the area are completely disturbed. The sand introduced in the littoral drift by means of this erosion is the probable source of the sediment that is now accumulating in the area around the pier of another harbor, the Pecém harbor, located in the next headland downdrift, 60 km west of Fortaleza harbor [4]. The degradation illustrates the changes related to extreme human interventions on a unidirectional system, associated with rising sea level.
\n
\n
3.2.1 Coastal mitigation in the metropolitan region of Fortaleza
\n
As erosion travels west, real estate owners along the shoreline try to protect their property by building coastal protection with their own resources or by pushing public power to build structures with public resources. In this way, several interventions were made in the last decades, of the rock-fill and bag-wall types.
\n
The rock-fills protect the coast from erosion; however, it results in the loss of the beach area and in increased erosion downdrift (\nFigure 6A\n). The bag-wall, built in the 2010s, on the other hand, has already been destroyed by the action of the waves (\nFigure 6B\n), showing it completely inefficient for solving the kind of problems created by the construction of the Mucuripe harbor and by the unsustainable type of urbanization of Fortaleza city.
\n
Figure 6.
(A) Erosion in Icarai Beach, 25 km downdrift of Mucuripe harbor, resulting from the interventions in Fortaleza city and in the area around the harbor. The rising of the sea must also be a factor producing the erosion. (B) Bag-wall installed in Icarai Beach in the 2010s, already destroyed by the waves.
\n
It seems clear that the erosion in the area will not cease with the kind of intervention that has been taking place in the last six decades. Effectively, it is necessary to consider that the waves are very active and that sand is missing in the shoreline. In addition, the sea level is rising. In [19], it is pointed out that the sands which are dredged from the harbor’s basin could be used to mitigate the erosion, by means of artificial nourishment of the beaches, as it takes place in other countries (e.g., [20]). Vasconcelos [16] advanced in this point of view, considering that the sand of the dredging could be dispersed along the littoral of Fortaleza, at the bathymetry of 5 m. Effectively, at 5 m deep, the longshore current would naturally transport the sands to the beaches downdrift, rebuilding coastal dynamics. This measure would waive nourishment of beaches, as well as the installation of rock-fills, bag-walls or other engineering structures and actions, implicating in less cost and less disturbance of the shoreline and of the social life related to it.
\n
Nevertheless, these suggestions have not yet been considered by public authorities. In fact, a new dredging took place in August/September 2018, and as before, the sands were transported offshore, to be deposed and lost in areas far away from the shoreline. Meanwhile, the aggressive, dramatic, disastrous, and degrading erosion and destruction of the north part of Ceará State coastal area keep taking place.
\n
\n
\n
\n
3.3 Environmental problems in Canoa Quebrada beach
\n
The town of Canoa Quebrada is located 140 km east of the city of Fortaleza and represents one of the most visited tourist destination in the coastal zone of the Northeast Brazil. It is characterized by the presence of active sea cliffs modeled in the Barreiras Formation, with the occurrence of a narrow beach in its foothills, plus beach rocks nearshore, which partially protects the sea cliffs (\nFigure 7\n). Clays and friable sands make up the sediments of the sea cliffs, which are bare or only partly protected by vegetation [21].
\n
Figure 7.
Reef line at Canoa Quebrada beach (adapted from Google Earth image, 2018).
\n
The morphodynamics in the area is very active: the strong rains that characterize the rainy season cause ravines and acute ridges, resulting in transport and deposition of sediments in the foothills, in the form of cones of dejection (\nFigure 8\n). The rain also contributes to the softening of the material of the cliff and to the increase of the water table, which produces dissolution in the slope and increases the internal pressure in the sediments, thus increasing the fragilization of the feature (e.g., [22]).
\n
Figure 8.
Grooves at the top and cone of dejection at the base of the sea cliffs of Canoa Quebrada.
\n
An important anthropogenic factor of the dynamics of the sea cliffs is the installation of numerous tourist facilities on their top and slope. These structures cause trampling and compacting of the sands, increasing ravines and generating gullies, which contributes to the acceleration of the erosive processes caused by rainwater (e.g., [23]) (\nFigure 9\n).
\n
Figure 9.
Occupation of the top and bottom of the sea cliffs of Canoa Quebrada.
\n
The cliffs of Canoa Quebrada have an average height of 15 m and can be considered as small- to medium-sized cliffs. However, the volume of material that is removed from these features is not negligible due to the high frequency of landslides. The occurrence of successive episodes of landslides is due to the combination of three factors: the friable nature of the clay-sandstone material, high anthropogenic presence, and strong tropical rainfall.
\n
The sea cliffs present slope angle usually under 45° and are characterized mostly by the occurrence of retreat controlled by milder gravitational sliding more than by abrupt collapses (\nFigures 10\n and \n11\n). Together with the type of wave breaking, sea level rising, tidal amplitude, and sediment granulometry, the inclination directly influences the erosive process that characterizes the sea cliffs today [24, 25].
\n
Figure 10.
(A) The cliff on January 16, 2016, and to the right on February 20, 2016. (B) The retreat of the sea cliff by gravitational slip is visible in the 2016 picture.
\n
Figure 11.
Topographic profiles of Canoa Quebrada sea cliffs.
\n
The analysis of the set of points where topographic profiles were made indicates that from east to west (profiles 1,2,3, \nFigure 11\n), the slope presents relatively smooth landslides, while in the westernmost portion of the beach, where the profile assumes an angulation of more than 45° (profiles 5 and 6, \nFigure 11\n), landslides occur. The analysis of satellite images containing a time series of the years 2004, 2008, and 2017 indicates that the velocity of retreat of the Canoa Quebrada sea cliffs is very high when compared to hard rock cliffs.
\n
Retreat velocity was calculated in three distinct sections, with the following results: in the east, the retreat was the smallest, of the order of 90 cm between 2004 and 2017, representing an average retreat of 8.2 m per century. In the central areas, which have many tourist developments, the retreat was slightly faster, of the order of 1.2 meters in 13 years, representing approximately 10.9 m per century. To the west, less sheltered area in relation to the attack of the waves due to smaller presence of beach rocks, the cliff receded 1.7 m in 13 years, equivalent to 15.5 m per century. The average speed of retreat of the cliff for the studied area is of 11.5 m per century.
\n
It is also observed that the line of rupture of the sea cliff in the image of 2017 presents recesses, with gaps and gullies that did not exist in 2004, indicating morphogenetic processes acting differently over the years. In 2004, the performance of the marine processes at the base of the cliff was dominant, with more intense and uniform retreat of the slope. The presence of retreat in the image of 2017 indicates that there was a change in the relation of forces between the active processes, being now the subaerial processes more intense than the marine ones. In synthesis, it is concluded that the cliffs rapidly recede by the combined action of wave attack, rising sea levels, rainfall, and human action.
\n
The average retreat velocity of the Canoa Quebrada sea cliff is compatible with the soft nature of the sediments that compose it. However, it is a very high speed if we consider the presence of an important urban nucleus and many tourist facilities located near or on the edge of the cliffs.
\n
Environmental risk prevention was never present in the urban planning of Canoa Quebrada. Natural and anthropic factors were not taken into account in the expansion of the village on the cliffs. However, the cliffs of Canoa Quebrada are fragile and present strong risks of landslides, as indicated by the survey realized and exposed above. These factors must be taken into account in planning the future use and occupation of the area, under penalty of material damages, environmental degradation, and unsafety to the public. It is also noted that in the central portion of the beach, there are ventures located very close to the foot of the cliff, running at great risk of burial by materials from the top, through the frequent landslides (\nFigure 12\n).
\n
Figure 12.
Tourist equipment installed very close to the unstable sea cliffs, running the risk of being buried by landslides.
\n
In this central area, it is strongly advisable to remove part of the existing tourist structures, thus ensuring the use of this equipment safely by tourists and inhabitants of the town.
\n
\n
\n
\n
4. Coastal environmental problems in northern Colombia
\n
\n
4.1 Natural settings of the study area
\n
The northern Colombia coast is located along the south side of the Caribbean Sea (latitude and longitude of the west and east boundaries are 11.1 north 74.9o west and 12.2 north 72.0 west, respectively) (\nFigure 13\n). The meteorological and oceanographic conditions are dominated by northeast trade wind, which results in the dominating northeasterly approaching wave occurring over 95% of the time. Effectively, northeasterly approaching waves occur by far the most frequently (\nFigure 14\n), driving a persistent westward longshore sediment transport.
\n
Figure 13.
The northern Colombia coast, located on the south side of the Caribbean Sea.
\n
Figure 14.
Regional wave modeling results for NE (45°) approaching wave. Example of the area Santa Marta—Barranquilla Cienaga.
\n
The general shoreline orientation of the study area is roughly 60 degrees, or striking WSW-ENE. The relatively straight shoreline is interrupted by two protruding headlands, Santa Marta and Cabo De La Vela. A broad shoreline orientation change occurs near Riohacha. To the west, the shoreline orientation is roughly 68°, while to the east, the orientation is roughly 52° or a change of 16° around the broad Riohacha headland. These shoreline orientation changes play a significant role in beach processes.
\n
Rocky coast dominates at both the Cabo de la Vela and Santa Marta headlands, with pocket sandy beaches distributing in the numerous embayment areas (\nFigure 15\n). Sandy beaches distribute along most of the coastline except at the headlands. Numerous rivers discharge into the Caribbean Sea. Most of the sandy beaches distribute directly along the mainland. The westward longshore sand transport is illustrated in this example from Riohacha by the sand impoundment along the east updrift side of the long groin (\nFigure 16\n).
\n
Figure 15.
Example of rocky coast at Santa Marta headland.
\n
Figure 16.
Example of sandy beach at Riohacha, accreted updrift by the help of jetties.
\n
Several spit type barrier islands extend along this stretch of coastline, originated from westward spit growth, and are of the wave-dominated type [26]. All the tidal inlets are quite narrow with small flood and ebb deltas. This is controlled by the fact that the tidal range is mostly less than 0.3 m even during spring tides, while wave forcing is relatively strong. Therefore, beach-inlet interaction only has localized influences on beach erosion and accretion. Wave plays a dominant role in shaping the coastline, since it is the dominating forcing, causing beach erosion or accretion. Extreme energetic conditions associated with direct hit or nearby passage of tropical storms can have significant and long-lasting impacts on coastal morphology.
\n
The beach processes along northern Colombia coast are relatively simple, driven predominantly by westward longshore sand transport. The trend of beach erosion or accretion and the state of the beach are largely controlled by the gradients of longshore sand transport, which can be caused by both natural and artificial factors.
\n
\n
\n
4.2 Environmental problems at Santa Marta: Barranquilla area
\n
About 19 km west of Barranquilla (km-19 site) (for location, see \nFigure 13\n), severe beach erosion has threatened a section of a major coastal highway (\nFigure 17\n). Presently, the highway is protected by recently installed riprap revetment. However, continued beach erosion is undermining the foundation of the riprap and likely the road in the near future. Furthermore, the erosion may continue to expand westward and propagate the problem over a larger area.
\n
Figure 17.
Severe beach erosion at 19 km site threatening a major highway. The recently installed riprap is experiencing toe scour due to continued erosion.
\n
Analysis of time-series aerial photos from Google Earth has shown that the beach along the km-19 coast is experiencing persistent rapid erosion from 2009 to 2015, at over 15 m per year. The sediment transport gradient along this stretch of coastline is caused by the shadowing effect of the Santa Marta headland, which creates a westward increasing wave height along the km-19 site. This results in more sediment being transported westward from the km-19 site than being transported into the site. A major coastal road to the city of Barranquilla is now practically at the shoreline (see \nFigure 17\n). Originally, the road was several hundred meters from the shoreline. In 2009, the distance was only 115 m. The waves along this section of the coast is quite energetic nearly all year round, and the longshore sediment transport gradient resulting is induced by natural morphological conditions.
\n
\n
\n
4.3 Environmental problems at Riohacha coastline
\n
The Riohacha coastline (for location, see \nFigure 13\n) provides an example of beach accretion and erosion associated with artificial interruption of the persistent westward longshore sand transport. \nFigure 18\n shows the aerial view of the Riohacha coastal line with a groin field. The groins were installed with the perspective to allow accretion of beaches.
\n
Figure 18.
Aerial view of the Riohacha shoreline. Note the large amount of sand accumulation at the east-most three groins and little to no sand accumulation at the rest of the groins and erosion further downdrift.
\n
Effectively, it is apparent that the groins at the updrift end have impounded a large amount of sand and resulted in a quite wide beach there (\nFigure 19\n). Several small rivers to the east and updrift of the beach contribute to the sand supply.
\n
Figure 19.
Large amount of sand accumulation updrift of the first groin. The groin is considerably higher than the beach.
\n
However, the field of these 150-m long groins nearly completely interrupted the westward longshore sand transport and resulted in severe beach erosion along a long and extending stretch of downdrift coast. \nFigure 20\n illustrates the erosion along the beach downdrift of the groin field. In addition, due to the depleted sand supply, the groins downdrift of the large beach failed to impound any sand. Similar sand bypassing patterns around and through a groin were found by [27] in a large-scale laboratory study on interaction of a groin with longshore sand transport.
\n
Figure 20.
Severe beach erosion downdrift of the Riohacha groin field, exposing a crucial infrastructure to direct wave attack.
\n
\n
\n
4.4 Environmental problems at Costa Verde Cienega
\n
Costa Verde Cienega (for location, see \nFigure 13\n) is located within the greater shadow zone of the Santa Marta headland and at the edge of the secondary shadow zone. The waves along this stretch of the coast are low due to the shadowing effect of the Santa Marta headland. A wave-height gradient exists along this stretch of the coast due to the secondary shadowing by the headland, although the rate of longshore sand transport should be much smaller due to the low wave. Beach erosion here has exposed a crucial pipeline along the coast (\nFigure 21\n). Various low-profile groins made of sand bags were installed in an effort to control the erosion. Based on field observations, the sandbag groins have very limited and localized effect.
\n
Figure 21.
Severe beach erosion along the Costa Verde Cienega coast, exposing a crucial pipeline (yellow marker). Note the low-profile sandbag groin and the earth-moving machine at the top of the picture. The earth-moving machine was moving sand from the upland to nourish the beach and attempting to control the erosion.
\n
In addition to the longshore sand transport gradient induced by natural processes, anthropogenic activities also play a significant role in the beach erosion in the area. The westward longshore sand transport and a transport gradient were induced by a 140-m long groin installed between January 2011 and May 2012. Rapid sand accumulation east and updrift of the long groin occurred. By May 2012, the updrift beach had grown to about 35 m landward of the tip of the long groin. Only 5 months later in October 2012, the updrift of the long groin was filled to the tip of the groin.
\n
The impoundment at the groin created a transport gradient at the downdrift, which further contributed to the beach erosion problems caused by the natural wave-height gradient associated with the secondary shadowing of the Santa Marta headland. Therefore, similar to the long groins at Riohacha, the downdrift beach did not benefit from sand bypassing even when the updrift beach reached the tip of the groin.
\n
\n
\n
4.5 Coastal mitigation in northern Colombia
\n
The above examples, along with numerous other cases in the northern Colombia coast, strongly suggest that caution should be carefully exercised in artificially interrupting the persistent westward longshore sand transport. Impounding the longshore moving sand by engineering structures, many times by groin field, is quite easy to do. The often very rapid beach accretion at the updrift side of the structure may lead to construction of longer and more groins. This can quickly turn into a very destructive practice along the tropical trade wind-dominated coast, where longshore sand transport is westward almost 100% of the time.
\n
Well-planned regional scale study should be developed in order to avoid these types of problems in the future. The study should investigate (1) the source and availability of the sand to the beach, (2) rate of longshore sand transport, and (3) most importantly, existing natural and anthropogenic causes of longshore sediment transport gradient. The study should have adequate temporal and spatial scales. Spatially, the study should include a long stretch of beach, particularly along the downdrift coast, to ensure that the downdrift effect induced by the shore protection structures is fully considered over a long period.
\n
\n
\n
\n
5. Conclusions
\n
Coasts along Northeast Brazil and northern Colombia are beautiful environments. Being popular tourist destinations as well as desirable living areas, these coasts can be very valuable economically. Tourism along the coast, particularly at sandy beaches, constitutes a large income for the two countries. The increasing of urban activities in these areas also induces to the installation of many key structures to the functioning of the urban and economic life, such as harbors. For instance, the areas are very vulnerable to numerous natural and anthropogenic stressors.
\n
The present study showed examples of the coastal environmental degradation caused by these stressors in two areas of northeast Brazil and three areas of northern Colombia. The erosion of the beaches in Brazil and Colombia and the collapse of sea cliffs of Canoa Quebrada, Brazil, cause damage to the population, either through the alteration of marine ecosystems or through the reduction of artisanal fishing, leisure, and recreation spaces or the reduction of fishing activities, vacation, and tourism. It leads to heavy losses to economic activity, such as job losses, decrease in the income and tax generation, and real estate depreciation.
\n
In such a context, it is necessary to better plan the occupation and uses of these coastal areas, in order to promote a sustainable development. Specifically, it is necessary to consider the fact that easterly trade wind has significant influence along the coastal area of both countries. It results in a dominating easterly approaching wave occurring over 95% of the time and then, in a unidirectional longshore transport, which has to be carefully considered in the moment to introduce equipment, structures, and housing in the shoreline. Considering that trade winds are in action in tropical areas, these findings should be applicable to many other tropical coasts.
\n
\n
Acknowledgments
\n
We thank the editorial assistance of Mr. Roger Morton.
\n
\n',keywords:"Northeast Brazilian coast, northern Colombian coast, coastal erosion, coastal mitigation",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/68450.pdf",chapterXML:"https://mts.intechopen.com/source/xml/68450.xml",downloadPdfUrl:"/chapter/pdf-download/68450",previewPdfUrl:"/chapter/pdf-preview/68450",totalDownloads:579,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,introChapter:null,impactScore:0,impactScorePercentile:38,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"February 22nd 2019",dateReviewed:"June 11th 2019",datePrePublished:"August 5th 2019",datePublished:"March 25th 2020",dateFinished:"August 5th 2019",readingETA:"0",abstract:"In the state of Ceará, northeast Brazil, in the 1950s, an industrial harbor was built. The harbor structures and other factors, such as the destruction of the bypass of dunes, produced a large erosive process downstream, responsible for the loss of 400 m of beach in six decades. In Canoa Quebrada beach—an internationally famous tourist area—recently, the partial collapse of sea cliffs occurred because of inappropriate uses and occupations, causing landscape and economic damage. In Colombia, beaches are under an intense process of erosion, due to construction for housing and tourism. With the abrasive action of waves associated with rising sea level, coastal areas in both countries are under risk of major degradation. These environmental situations are the object of technical and scientific analysis and discussion in this chapter, and mitigation propositions are considered.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/68450",risUrl:"/chapter/ris/68450",book:{id:"8007",slug:"estuaries-and-coastal-zones-dynamics-and-response-to-environmental-changes"},signatures:"Vanda Claudino-Sales, Ping Wang, Fábio Perdigão Vasconcelos and Adely Pereira Silveira",authors:[{id:"296615",title:"Prof.",name:"Vanda",middleName:null,surname:"Claudino-Sales",fullName:"Vanda Claudino-Sales",slug:"vanda-claudino-sales",email:"vcs@ufc.br",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Universidade Federal do Ceará",institutionURL:null,country:{name:"Brazil"}}},{id:"296616",title:"Prof.",name:"Ping",middleName:null,surname:"Wang",fullName:"Ping Wang",slug:"ping-wang",email:"pwang@usf.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of South Florida",institutionURL:null,country:{name:"United States of America"}}},{id:"296617",title:"Prof.",name:"Fabio Perdigao",middleName:null,surname:"Vasconcelos",fullName:"Fabio Perdigao Vasconcelos",slug:"fabio-perdigao-vasconcelos",email:"fabioperdigao@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"State University of Ceará",institutionURL:null,country:{name:"Brazil"}}},{id:"296618",title:"Dr.",name:"Adely",middleName:null,surname:"Silveira",fullName:"Adely Silveira",slug:"adely-silveira",email:"delysilveira@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"State University of Ceará",institutionURL:null,country:{name:"Brazil"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Methodology",level:"1"},{id:"sec_3",title:"3. Environmental problems in the coast of Ceará State, Northeast of Brazil",level:"1"},{id:"sec_3_2",title:"3.1 Natural settings of the study area",level:"2"},{id:"sec_4_2",title:"3.2 Coastal environmental problems in Fortaleza area",level:"2"},{id:"sec_4_3",title:"3.2.1 Coastal mitigation in the metropolitan region of Fortaleza",level:"3"},{id:"sec_6_2",title:"3.3 Environmental problems in Canoa Quebrada beach",level:"2"},{id:"sec_8",title:"4. Coastal environmental problems in northern Colombia",level:"1"},{id:"sec_8_2",title:"4.1 Natural settings of the study area",level:"2"},{id:"sec_9_2",title:"4.2 Environmental problems at Santa Marta: Barranquilla area",level:"2"},{id:"sec_10_2",title:"4.3 Environmental problems at Riohacha coastline",level:"2"},{id:"sec_11_2",title:"4.4 Environmental problems at Costa Verde Cienega",level:"2"},{id:"sec_12_2",title:"4.5 Coastal mitigation in northern Colombia",level:"2"},{id:"sec_14",title:"5. Conclusions",level:"1"},{id:"sec_15",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'\nClaudino-Sales V. Les littoraux du Ceará Evolution géomorphologique de la zone côtiėre de l’Etat du Ceará, Nord-est du Brésil [Thesis]. Paris: Université Paris-Sorbonne; 2002\n'},{id:"B2",body:'\nClaudino-Sales V. Os litorais cearenses. In: Borzacchiello J, Cavalcante T, Dantas E. (Org.). Ceará: Um novo olhar geográfico. Fortaleza: Edições Demócrito Rocha. 2005:189-210\n'},{id:"B3",body:'\nClaudino-Sales V. Cenários Litorâneos: Natureza e Ambiente na Cidade de Fortaleza, Ceará [Master’s Dissertation]. São Paulo: University of São Paulo; 1993\n'},{id:"B4",body:'\nClaudino-Sales V, Wang P, Carvalho AM. Interactions between various headlands, beaches and dunes in the coast of Ceará state, Northeast Brazil. Journal of Coastal Research. 2018;34:413-428. DOI: 10.2112/JCOASTRES-D-16-00173\n'},{id:"B5",body:'\nPedrosa AA. A geodinâmica e morfogênese das dunas eólicas na Praia de Canoa Quebrada, Aracati, Ceará, Brasil [Thesis]. Fortaleza: Universidade Federal de Ceará; 2016\n'},{id:"B6",body:'\nCastro JWA. Burying processes carried out by a mobile transversal dunefield, Paracuru County, state of Ceará, Brazil. Environmental Geology. 2005;49:214-218. DOI: 10.1007/s00254-005-0055-6\n'},{id:"B7",body:'\nJiminez JA, Maia LP, Serra J, Morais JO. Aeolian dune migration along the Ceara Coast, northeastern Brazil. Sedimentology. 1999;46:689-701. DOI: 10.1046/j.1365-3091.1999.00240.x\n'},{id:"B8",body:'\nWang W, Saha S, Pan HL, Nadiga S, White G. Simulation of ENSO in the new NCEP coupled forecast system model (CFS03). Weather Review. 2005;133:1574-1593. DOI: 10.1175/mwr2936.1\n'},{id:"B9",body:'\nZanela ME. As características climáticas e os recursos hídricos do Estado do Ceará. In: Silva JB, Dantas EWC, Meireles AJA, editors. Ceará: um novo olhar geográfico. Fortaleza: Edições Demócrito Rocha, 2a edição; 2007. pp. 169-188\n'},{id:"B10",body:'\nFUNCEME (Fundação Cearense de Metereologia e Recursos Hídricos). Dados dos postos pluviométricos do Estado do Ceará. Retrieved from www.funceme.br/calendario/produto/municipio/; 2018\n'},{id:"B11",body:'\nINPH (Instituto Nacional de Pesquisas Hidroviárias). Simulação do regime de ondas no Pecém, Ceará (Report). Rio de Janeiro; 1996\n'},{id:"B12",body:'\nMaia LP. Procesos costeiros y balancio sedimentario ao largo de Fortaleza (NE Brasil): Implicaciones para un gestión adecuada de la zona litoral [Thesis]. Barcelona: University of Barcelona; 1998\n'},{id:"B13",body:'\nDHN (Diretoria de Hidrografia e Navegação). Tábua de Marés do Porto do Mucuripe (Report). Fortaleza; 2018\n'},{id:"B14",body:'\nMartin L, Suguio K. Variation of coastal dynamics during the last 7000 years recorded in beach-ridge plains associated with river mouths: Example from the central Brazilian coast. Palaeogeography, Palaeoclimatology, Palaeoecology. 1999;99:119-140 \n'},{id:"B15",body:'\nVasconcelos FP, Morais JSD, Diniz MT, Rego-Filho FF, Rocha GC Determination of shoreline variations of the metropolitan region of Fortaleza (Ceará State - Brazil) using methodology of GIS. In: Proceeding of CoastGIS 2007; Vol. 2. Santander, Spain: Copicentro-Bonifaz; 2007. pp. 233-343\n'},{id:"B16",body:'\nVasconcelos FP. Dinâmica Costeira do Litoral de Fortaleza e os impactos da construção dos aterros das praias do Meireles (Beira-Mar) e Iracema sobre o litoral de Caucaia (Report). Universidade Estadual do Ceará - UECE. Laboratório de Gestão Integrada da Zona Costeira – LAGIZC. Fortaleza; 2018\n'},{id:"B17",body:'\nMorais JO. Aspectos de Geologia Ambiental Costeira do Município de Fortaleza, Ceará [Thesis]. Fortaleza: Universidade Federal do Ceará; 1980\n'},{id:"B18",body:'\nPitombeira ES. Litoral de Fortaleza – Ceará – Brasil, um exemplo de degradação. In: Anais do 1° Simpósio sobre Processos Sedimentares e Problemas Ambientais na Zona Costeira do Nordeste do Brasil. Recife: ABEQUA; 1995. pp. 59-62\n'},{id:"B19",body:'\nMorais JO. Geological assessment of environmental impact on the Littoral of Fortaleza, Ceará, Brazil. Urban Risk. 1993;4:23-39\n'},{id:"B20",body:'\nPaskoff R. Les Littoraux: L’impact des aménagements sur leur évolution. Paris: Editora Armand Colin; 2010\n'},{id:"B21",body:'\nMeireles AJA. Falésias do litoral leste do estado do Ceará – Análise dos Processos Morfogenéticos e Impactos Ambientais. Revista Geonotas. 1999;3(2):1-29\n'},{id:"B22",body:'\nVeyret Y. Les Risques. Paris: SEDES; 2003\n'},{id:"B23",body:'\nMiossec A. De l’érosion cotiére em general et le cas français en particulier. La Géographie Terre de Hommes. Numéro Especial: L’érosion. Octobre - Décembre 2018;1571:28-34\n'},{id:"B24",body:'\nBird E. Coastal Geomorphologie, An Introduction. Chichester: Wiley; 2000\n'},{id:"B25",body:'\nMerlotto A, Bértola GR, Isla FI, Cortizo LC, Piccolo MC. Short and medium-term coastal evolution of Necochea municipality, Buenos Aires province, Argentina. Environment and Earth Science. 2014;71:1213-1225. DOI: 10.1007/s12665-013-2525-6\n'},{id:"B26",body:'\nDavis RA, Hayes MO. What is a wave-dominated coast? Marine Geology. 1984:313-329\n'},{id:"B27",body:'\nWang P, Kraus N. Movable-bed model investigation of groin notching. Journal of Coastal Research. 2004, special issue;33:342-368\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Vanda Claudino-Sales",address:"vcs@ufc.br",affiliation:'
Federal University of Ceara State, and Master on Geography, Acarau Valley State University, Brazil
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1. Introduction
Herbs is defined as “any plants that lack the woody tissue characteristic of shrubs or trees” [1, 2, 3, 4, 5, 6, 7]. Several herbs have shown positive effects against a variety of inflammatory medical problems, such as dysphagia, gastric ulcers, wound healing, and sore throat. It is the core component of the complementary and alternative medicine (CAM) [1, 2, 3, 4, 5, 6, 7]. It has been used to manage blood problems and eliminate waste, stimulate body and blood circulation, minimize irritation [1, 2, 3, 4, 5, 6, 7]. It has several forms such as tablets, syrups, or it can be used externally as a dressings, or topical application [1, 2, 3, 4, 5, 6, 7].
Herbs could have a potential beneficial effect in the dental field, such as with gum swelling, specifically, and in oral healthcare overall. However, few studies have scientifically reviewed these topics. In this chapter, the most common herbal supplements that can be used in dentistry (i.e., neem, ginger, clove, aloe vera, eucalyptus, garlic, miswak, turmeric, tulsi, charcoal, and cinnamon) are reviewed. Evidence-based findings will be presented to support or refute the use of these agents in oral care.
2. Most common herbs used in dentistry
2.1 Aloe Vera
Aloe vera is effective in periodontal disease conditions [1]. It is available in several forms, such as a mouthwash, toothpaste, or gel [1]. In a recent systematic review, aloe vera as a mouthwash was effective in all included studies in reducing plaque and gingival inflammation (Table 1, [2]). Moreover, aloe vera had no or very minimal side effects compared to other chemical mouthwashes [2]. It has a strong detoxifying agent, a neuro-sedative properties and immune booster [1, 2]. It can act as a mercury scavenger and antioxidant. It accerlated healing after surgical extraction including the third molar [1, 2].
Herbs
Main dental use
Main oral targeted organism
Aloe vera
Periodontal index, gingival scores, inhibitory activities on some organisms, intracanal Medicaments, oral medicine, after extraction, ill fitting denture, around implants complications.
Inhibit the decalcification and promote the remineralization, topical agent, anti-bacterial
S. mutans, Porphyromonas gingivalis, Prevotella intermedia, Candida albicans, Herpes Simplex virus 1 and 2
Cinnamon
Endodontic irrigate solution, antimicrobial properties against cariogenic bacteria and fungicidal activity .
E. faecalis, Candida tropicalis and Candida glabatra
Garlic
Inhibition of the growth of the periodontal pathogens, Endodontic irrigate solution.
Aggregatibacter actinomycetemcomitans, P. gingivalis, Fusobacterium nucleatum, Streptococcus mutans and Lactobacillus acidophilus
Neem
Endodontic irrigation soluation, antiviral, antibacterial, antisclerotic and antiinflammatory properties. A local drug delivery system, inhibition of oral epithelial cell carcinoma.
E. faecalis, P. gingivalis, S. mutans, S. faecalis, S. salivarius, S. mitis, and S. sanguis
Porphyromonas gingivalis and Herpes simplex virus-1.
Turmeric
Antibacterial, antitumor, antioxidant, anti-inflammatory and analgesic properties. Mouth rinse, erythematous halo, ulcer size, and pain, oral submucous fibrosis
Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia.
Tulsi
Antimicrobial agents. Toothpaste or mouthwash
A. actinomycetemcomitans, P. gingivalis and P. intermedia
Green tea
Antibacterial properties. Minimize bone loss in periodontal disease cases, mouth rinse, local drug delivery, and chewing gum.
Streptococcus mutans, Streptococcus sobrin, P. gingivalis and P. melaninogenicus.
Chamomile
Anti-inflammatory property, mouth rinse for gingivitis and periodontal disease, management of burning mouth syndrome, irrigant solution.
Porphyromonas gingivalis
Fenugreek
Gingival index, plaque index, bleeding on probing, pocket depth, and clinical attachment levels.
Anise plant
Antibacterial properties, mouth rinse, increase healing process
E. corrodens and Prevotella spp.
Peppermint
Toothpaste or mouth rinse, antibiofilm properties. Topical analgesic and reduces pain. Treatment of gingivitis, periodontitis, oral mucosa of viral, bacterial, fungal and protozoal etiology. Decrease the treatment time, faster tissue regeneration, faster relieved pain and swelling, and improved the patients’ quality of life. Mouthwash.
Streptococcus mutans
Bloodroot
Periodontal disease, toothpaste or other oral hygiene products.
P. gingivalis.
Carawa
Mouth wash in gingivitis or periodontal disease. Flavor component in toothpaste and mouthwash products.
Fusobacterium nucleatum, early and late bacterial colonizers .
Eucalyptus
Anti-bacterial, antibiotics and oral infections prevention, dissolve root canal sealer
A. actinomycetemcomitans and P. gingivalis, Streptococcus mutans, Lactobacillus acidophilus
Phyllanthus emblica
Antimicrobial, antioxidant, antiresorptive and antiinflammatory activity. Locally delivered gel
Group of bacteria
Black seed
Suppresses pro-inflammatory cytokines, anti-bacterial, and decrease oral halitosis.
Porphyromonas gingivalis, A. actinomycetemcomitans and Prevotella intermedia, S. mutans, Enterobacter cloacae, Streptococcus oralis, Streptococcus anginosus, Staphylococcus epidermide.
Myrrh
Antimicrobial properties, immune enhancer. Topical or a mouth wash, manage pharyngitis, tonsillitis, gum swelling, aphthous ulcers, intramucosal wounds, gingivitis and ulcers. Anti-inflammatory activity such as IL-1β, IL-6, and TNF-α.
Streptococcus mutans, Lactobacillus spp, Porphyromonas gingivalis, A. actinomycetemcomitans, Treponema denticola, and Tannerella forsythia
Spasmodic, whooping cough, oral herpes, chronic candidiasis and halitosis.
S. aureus, E. coli, C. albicans Streptococcus mutans
Table 1.
The most common herbs used in dentistry and the dental application.
Aloe vera toothpaste is another form that is effective on periodontal index and gingival scores and that can be used as an alternative to traditional toothpaste [3]. Aloe vera gel has inhibitory activities on some cariogenic organisms (Streptococcus mutans) [4], such as periodontopathic (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis) and an opportunistic periodontopathogen (Bacteroides fragilis) [4]. It can be used as intracanal medicaments against Enterococcus faecalis (Table 1, [5]). It can be used to manage antiviral infection such as herpes simplex and herpes zoster, or as an antifungal agent against candida albicans [3, 4, 5].
There are several other uses for aloe vera such as aid in chemical burns, dry sockets, relief of aphthous ulcers, canker sores, lichen planus, pemphigus, desquamative gingivitis, migratory glossititis, and burning mouth syndrome [1, 2, 3, 4, 5]. It can helps in reducing the information related to ill-fitting dentures [1, 2, 3, 4, 5]. It can also be used in peri-implant mucositis and peri-implantitis [1, 2, 3, 4, 5].
2.2 Ginger
Ginger, which is scientifically named Zingiber officinale roscoe, can be used as a pain killer and is as effective as ibuprofen [6]. It can be used as an alternative for ibuprofen [6]. Combined with non-surgical periodontal therapy in chronic periodontitis cases among the type 2 diabetes population, ginger can help [7]. The reducing colony forming unit (CFUs/uL) of S. mutans is comparable to other oral rinses, such as chlorhexidine, and is also effective against Lactobacillus (Table 1).
Ginger may be a promising anti-cariogenic against Streptococcus mutans and Streptococcus sobrinus [7]. It contains phenolic compounds such as gingerol and shogaol, hydrocarbons, and oleoresins. These compounds have been investigated and shown to be effective anti-inflammatory, anti-bacterial, and antioxidant agents in oral micro-organisms, which can help in disease prevention [8]. Moreover, ginger can help to reduce costs and side effects, and can introduce a safe inhibitory agent compared to conventional mouthwash [9]. It can be used also as an intracanal dressing, and in cases with recurrent apthous stomatitis and denture stomatitis [6, 7, 8]. However, it can lead to gastrointestinal irritation, heartburn, or diarrhea [6, 7, 8]. It can interfere with warfarin and inhibit platelet aggregation [6, 7, 8].
2.3 Clove
The principal phenolic components of clove, which is known scientifically as Syzygium aromatic (S. aromatic), are volatile oil, eugenol, and eugenyl acetate. It has some physical properties that have an adverse effect on surface roughness and hardness, as well as transverse strength [10, 11, 12, 13]. A high dose of clove oil can cause serious problems, such as sore throat, vomiting, toxicity, damage to the kidney and liver, epilepsy, and difficulty breathing. In small doses, it can inhibit decalcification and promotes remineralization (Table 1, [14]). It can be used as a topical agent, as a benzocaine before needle insertion, and has similar pain scores [15]. The crude extract of S. aromaticum (clove) has shown inhibitory activity against periodontal oral pathogens, including S. mutans (Table 1, [16]).
Other potential dental uses include antibacterial activity against Porphyromonas gingivalis and Prevotella intermedia [13]. It minimize several cytokines and factors such as IL-6, COX-2 and TNF-α. It has antifungal activity against Candida albicans [10, 11, 12, 13, 14, 15, 16], and antiviral activity against Herpes Simplex virus 1 and 2 [10, 11, 12, 13, 14, 15, 16]. It can be used as mouthwashes, toothpastes, topical agents and local drug delivery devices [10, 11, 12, 13, 14, 15, 16]. Clove and its components are generally considered as “safe”. However, it has been demonstrated as a cytotoxic agent towards fibroblasts and endothelial cells in vitro studies [10, 11, 12, 13, 14, 15, 16]. Moreover, hepatotoxicity, generalized seizures and disseminated intravascular coagulopathy has been reported as severe side effects [10, 11, 12, 13, 14, 15, 16]. Other potential side effects include skin irritation, ulcer formation, contact dermatitis, tissue necrosis, and delayed healing [10, 11, 12, 13, 14, 15, 16].
2.4 Cinnamon
Cinnamon is commonly referred to Cinnamon Zeylanicum or Cinnamon cassia. It can be used as an endodontic irrigant to minimize the E. faecalis, which is comparable to 3% of sodium hypochlorite [17]. Cinnamon has good antimicrobial properties against cariogenic bacteria such as S. mutans and Lactobacillus casei [18], as well as fungicidal activity against Candida tropicalis and Candida glabatra (Table 1, [18]).
Chewing gum containing cinnamon may help in the management of halitosis cases by minimizing volatile sulfur compounds inside the oral cavity [19]. The toothpaste that contained Cinnamomum zeylanicum showed anti-bacterial activity against periodontal pathogens (Table 1, [20]). It can be used in the dental unit water lines, which minimized bacterial count [21].
There are potential side effects such as tooth discoloration with high exposure to cinnamon [17, 18, 19, 20, 21], allergic reaction such as swelling, inflammation, burning, soreness of the mouth and lips [17, 18, 19, 20, 21].
2.5 Garlic
Several in vitro studies found that the inhibition of the growth of the periodontal pathogens can happen with the aqueous extract, allicin [22], and diallyl sulfide of garlic [23]. The targeted pathogens are Aggregatibacter actinomycetemcomitans, P. gingivalis, and Fusobacterium nucleatum (Table 1, [24]).
When used as an irrigant, it is an effective, safe, and natural product, and is comparable to sodium hypochlorite after using it for a period of 12 months following root canals of primary molars [25]. The maximum zone of inhibition against cariogenic bacteria, such as Streptococcus mutans and Lactobacillus acidophilus, was in hard neck garlic extract, followed by chlorhexidine mouthwash [26]. The methanolic component of garlic had no anti-bacterial effects on S. aureus and P. aeruginosa [27].
Unpleasant breath or body odor is the most common side effects of garlic use [22, 23, 24, 25, 26, 27]. Other side effects include heartburn, burning in a mouth or throat [22, 23, 24, 25, 26, 27]. Patients need medical advice before garlic use if he/she is taking the following medications: acetaminophen; birth control pills; or warfarin [22, 23, 24, 25, 26, 27].
2.6 Neem
Neem is scientifically known as Azadirachta indica and can be used as an endodontic irrigation solution to minimize the E. faecalis, which is comparable to 3% of sodium hypochlorite [17]. It has antiviral, anti-bacterial (S. mutans, S. faecalis, S. salivarius, S. mitis, and S. sanguis), anti-sclerotic, and anti-inflammatory properties. A local drug delivery system using 10% neem oil chip statistically reduced P. gingivalis and all clinical parameters in periodontal-diseased patients (Table 1, [28]).
The highly pure neem leaf extract has proven potential inhibition of oral epithelial cell carcinoma through downregulation of intra tumor pro inflammatory pathways [29]. However, it was less effective in plaque scores reduction among orthodontic patients compared to Salvadora persica miswak-based mouthwash [30]. It has Anti-candidial activity against C. albicans, and it inhibits S. mutans and E. faecalis which cause root canal failure in endodontic procedure [17, 28, 29, 30].
2.7 Miswak
Salvadora persicahas have potential benefits in reduction of plaque, bacterial oral germs, cavity prevention, and halitosis [31]. It contains high amounts of calcium, chloride, phosphate, and thiocyanate, which, as a consequence, can affect saliva and oral health [32]. When used in the dentifrice, it can lead to significant reduction in plaque index scores compared to conventional dentifrice [33]. The miswak raw extract is effective against Porphyromonas gingivalis and herpes simplex virus-1 in chronic periodontitis patients (Table 1, [34]).
The mouthwash form has been investigated as an effective method for plaque reduction [35]. It can also be used as a chewing gum, mouthwash, and chewing stick [31, 32, 33, 34, 35]. It has remineralization effects following dental caries. Miswak can accelerate the wound healing after oral/periodontal surgery or extraction. It has potential anti-cariogenic, whitening properties and orthodontic chain preservation [35].
2.8 Turmeric
Curcumin (Turmeric) has shown anti-bacterial, anti-tumor, antioxidant, anti-inflammatory, and analgesic properties [36]. It can be used as a topical application, mouthwash, subgingival irrigant or local drug delivery system to treat periodontal diseases, with equivalent or even higher efficacy compared with chlorhexidine in periodontopathic bacteria reduction such as Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia (Table 1, [36]).
The extract gel can be used as a treatment for erythematous areas, ulcers, and pain [37]. It can help in cases with oral submucous fibrosis, leukoplakia, lichen planus and it gave better results compared with the systemic form alone, or antioxidants (Table 1). It has anticancer activity as well [36, 37].
Although it considered safe, it may cause gastric irritation, nausea, diarrhea, allergic reaction, and interfering with blood-clot formation [36, 37].
2.9 Tulsi
Tulsi is released in several metabolites found in these plants, which have antimicrobial agents. It can be used in toothpaste or mouthwash [38]. It is similar to chlorhexidine in its antimicrobial property, and as an alternative in patients who cannot use chlorhexidine [39]. Tulsi extracts have antimicrobial activity against A. actinomycetemcomitans, P. gingivalis, and P. intermedia, with different inhibition zones (Table 1, [40]).
2.10 Green tea
Green tea and its principal compound (flavonoid epigallocatechin-3-gallate) are responsible for protective effects against several diseases and has anti-bacterial properties [41]. They can minimize bone loss in osteoporosis and periodontal disease cases by inducing apoptotic cell death of osteoclasts and osteoclasts-like cells (Table 1, [41]).
Green tea extract rich in epigallocatechin gallate minimizes alveolar bone loss in rats with periodontal disease [42]. It can be used in different forms, such as mouthwash, local drug delivery, and chewing gum. It has catechins that is anti-bacterial against Streptococcus mutans, Streptococcus sobrin, P. gingivalis, and P. melaninogenicus (Table 1, [42]).
2.11 Chamomile
Chamomile, known as Matricaria recutita, contains volatile oils, flavonoids, apigenin, luteolin, and quercetin [43]. It has an anti-inflammatory property that is as effective as a mouthwash for gingivitis and periodontal disease. There was a zone of inhibition when tested against P. gingivalis (Table 1, [44]). However, eucalyptus oil was the most effective, followed by tea tree oil, chamomile oil, and turmeric oil [45]. It can be used in management of burning mouth syndrome cases and as an irrigate solution (Table 1, [46]). It can be used topically in the treatment of eczema [43, 44, 45, 46]. In fact, a randomized clinical trial found it to be equivalent to hydrocortisone cream [43, 44, 45, 46]. However, it can cause allergic reactions which included bronchial constriction and skin reactions [43]. It is controversial to use with a pregnant women since it caused a newborn death in a single case report.
2.12 Fenugreek
There was a significant reduction in several parameters, such as gingival index, plaque index, bleeding on probing, pocket depth, and clinical attachment levels, when fenugreek was used clinically (Table 1, [47]). It has antibacterial activity against S. mutans, biofilm formation and acid production [47]. It was able to increase the salivary pH up to 7.83 and decreased the demineralization of the tooth’s outer surface [47]. Fenugreek is considered unsafe to use during pregnancy, breastfeeding and for children. Do not use this product without medical advice if you are pregnant [47]. It can interact with blood sugar levels and cause hypoglycemia), or cause bleeding/blood clotting disorders [47].
2.13 Anise Plant
Anise has potent anti-bacterial properties due to the presence of anethole [43]. It has a strong effect against Staphylococcus aureus, as well as some gram-positive and gram-negative microorganisms. In the oral cavity, it works on anaerobic and facultative aerobic periodontal bacteria such as E. corrodens and Prevotella spp (Table 1, [43]). When used as a mouthwash, it was comparable to chlorhexidine in reducing bleeding on probing and increasing the healing process [43]. Anise is likely safe for most adults [43].
2.14 Peppermint
Mentha piperita can be used in a toothpaste or mouthwash, which showed anti-biofilm properties against Streptococcus mutans and dental plaque (Table 1, [48]). It can be used topically as an analgesic and to reduce pain. It can also reduce a toothache [48]. It showed antimicrobial, analgesic, anti-inflammatory, immunomodulatory, and astringent properties. It can be used in treatment of gingivitis, periodontitis, and oral mucosa of viral, bacterial, fungal, and protozoal etiology (Table 1). It can lead to a decrease in treatment time, faster tissue regeneration, faster relieved pain and swelling, and improved quality of life for the patients. It has also been used as a mouthwash [48]. It can be used safely in most of the cases [48]. However, it may interfere with iron absorption [48]. It can cause burning and gastrointestinal distresses in some cases. It is contraindicated in patients with chronic heartburn, severe liver damage, gallbladder inflammation or obstruction [48], and peppermint oil should be avoided in any facial application on children and infants [48].
2.15 Bloodroot
Bloodroot is an alkaloid known as Sanguinaria canadensis. It has been used for periodontal disease due to its ability to inhibit the growth of oral bacteria such as P. gingivalis (Table 1, [43]). It’s available in toothpaste or as other oral hygiene products, and it is safe in long-term use. However, a recent report found that dental preparations with bloodroot may be associated with leukoplakia which is a precancerous lesion [43]. It is contraindicated in children, pregnant or lactating women [43]. The overdose can lead to stomachache, diarrhea, visual impairment, glaucoma, miscarriage, paralysis, and heart disease [43].
2.16 Caraway
The main components of Carum carvi are carvone and limonene. It can be used as a mouthwash in gingivitis or periodontal disease (Table 1, [43]). It can also be used as a flavor component in toothpaste and mouthwash products. It can target Fusobacterium nucleatum and early- and late-bacterial colonizers on tooth surfaces [43]. However, it should not be used in children under 2 years old because it may be cause irritation to the skin and mucous membranes [43].
2.17 Eucalyptus
Eucalyptus is effective against A. actinomycetemcomitans and P. gingivalis (Table 1). It can be used as a promising alternative to antibiotics and oral infections prevention [49]. It can stimulate the innate cell-mediated immune response, tumor chemotherapy [50]. Eucalyptus oil has the ability to dissolve root canal sealer (Table 1, [51]). It has anti cariogenic activity against Streptococcus mutans and Lactobacillus acidophilus [49, 50, 51]. There are several potential side effects associated with the use of Eucalyptus such as: allergy, rashes, burning sensation, drowsiness, difficulty in breathing, cardiovascular collapse and multi-organ failure due to substantial ingestion of eucalyptus mouthwash [49, 50, 51].
2.18 Phyllanthus Emblica
Emblica officinalis has several properties, such as cytoprotective, antimicrobial, antioxidant, anti-resorptive, and anti-inflammatory activity. It can be used as a locally delivered gel and as an adjunct to scaling and root planning, which will reduce the periodontal inflammation in chronic periodontitis cases compared with scaling alone [52]. It can reduce all strains of yeasts stick in the buccal epithelial cells compared with normal saline solution [53]. It can be used a mouthwash to treat mouth ulcers, and aphthous [52, 53]. It is the best remedy for scurvy due to vitamin C contents and pain reliefs [52, 53]. Even though Phyllanthus has been used as traditional medicine for long term, side effects may include stomach upset and diarrhea [52, 53]. It should be avoided in children, pregnant women, breastfeeding mothers, and patients with Wilson’s disease [52, 53]. It can inhibit blood clotting and should not be used plavix (clopidogrel) because it increased bleeding [52, 53].
2.19 Black seed
Miracle herb, or Nigella sativa, can reduce nitric oxide levels and inhibit pro-inflammatory cytokines such as IL-1b, IL-6, TNF-α, IFN-c, and PGE2. It can also increase the anti-inflammatory IL-10 [54, 55]. It works against Porphyromonas gingivalis, A. actinomycetemcomitans, and Prevotella intermedia(Table 1). It also decreases oral halitosis [54, 55, 56, 57, 58]. The black seed were found to have a bactericidal effect surface inhibition against S. mutans [54, 55, 56, 57, 58]. It can be used as an intracanal antisepsis in root canal therapy due to its activity against Enterobacter cloacae, Streptococcus oralis, Streptococcus anginosus, and Staphylococcus epidermides [54, 55, 56, 57, 58]. It has beneficial effects on oral ulcerations, oral mucositis, bone and wound healing after extraction or surgery [54, 55, 56, 57, 58].
2.20 Myrrh
Commiphora molm has three components: the resin, the gum, and the volatile oil. It has antimicrobial properties and immune enhancer [59, 60, 61]. It can be used as a topical or a mouth wash to manage pharyngitis, tonsillitis, gingivitis and ulcers with 2–3 times per day [59, 60, 61]. There is no known side effects with its used [62, 63, 64, 65]. It works against caries bacteria such as Streptococcus mutans and Lactobacillus spp, and periodontal disease microbes such as Porphyromonas gingivalis, A. actinomycetemcomitans, Treponema denticola, and Tannerella forsythia(Table 1, [62, 63, 64, 65]). It has anti-inflammatory activity through proinflammatory cytokines reduction such as IL-1β, IL-6, and TNF-α [66]. It can be used in cases with gum swelling, aphthous ulcers, and intramucosal wounds [62, 63, 64, 65, 66]. It can lead to significant reduction in plaque and gingival inflations compared with 0.2% Chlorhexidine Gluconate mouthwash [64].
2.21 Rosemary
Rosmarinus officinalisy has antioxidant activity and effective as an antibacterial and antifungal agents [43]. It can inhabit cancer development in animal studies [43]. It works against Staphylococcus aureus, Staphylococcus albus, Vibrio cholerae and Escherichia coli(Table 1, [43]). However, it should be avoided during pregnancy to minimize the risk of abortion [43]. It can lead to iron deficiency in same cases as well [43].
2.22 Sage
The main components of Salvia officinalis are alpha and beta-thujone, rosmarinic acid, camphor, tannins, flavonoids, and cineole [43]. It can be used as mouthwash or gargle several times to treat a sore throat and gingivitis [43]. It has antibacterial (Streptococcus mutans, Lactobacillus rhamnosus, and Actinomyces viscosus), and antifungal (Candida albicans) (Table 1, [43]). The long term used can increased heart rate, caused mental confusion and convulsions [43]. It should be avoided during pregnancy and cases with fever [43].
2.23 Thyme
Thymus vulgaris is one of the most commonly recommended herbs in Europe in spasmodic and whooping cough [43]. It can be used to treat oral herpes, chronic candidiasis and halitosis [43]. It targeted S. aureus, E. coli and C. albicans [43]. Patients with orthodontic brackets can used it as varnish to reduce Streptococcus mutans near the bracket (Table 1, [43]).
3. Conclusions
Herbal medicine can be beneficial in the dental field in dental caries, periodontal disease, candida and viral infection, oral ulcers and lesions. It has several advantages such as easy accessibility, natural products, low cost and toxicity, and faster healing time. However, it can lead to serious problems if used inappropriately. Therefore, a physician consultation is required before any dental use to avoid any potential complications or drug interaction, and a deeper investigation, preclinically and clinically, is needed before official herbal medicine use is highly recommended.
Conflict of interest
The authors declare no conflict of interest.
\n',keywords:"bacterial plaque, herbs, oral health, gingiva, periodontal disease, caries",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/80839.pdf",chapterXML:"https://mts.intechopen.com/source/xml/80839.xml",downloadPdfUrl:"/chapter/pdf-download/80839",previewPdfUrl:"/chapter/pdf-preview/80839",totalDownloads:69,totalViews:0,totalCrossrefCites:0,dateSubmitted:"December 18th 2021",dateReviewed:"February 15th 2022",datePrePublished:"March 14th 2022",datePublished:null,dateFinished:"March 14th 2022",readingETA:"0",abstract:"Herbal medicine has long been used to prevent and control disease, and it can minimize the potential side effects of chemical products. However, side effects from herbs do exist. Most of the challenges with herbal medicine revolves around inadequate information about the effect of herbs in the oral cavity, the mechanism of action, and potential side effects. There are several herbs described in this chapter have anti-inflammatory, anti-bacterial, anti-viral, anti-fungal in oral micro-organisms. It includes aloe vera, ginger, clove, cinnamon, garlic, neem, miswak, turmeric, tulsi, green tea, chamomile, fenugreek, anise plant, peppermint, bloodroot, caraway, eucalyptus, phyllanthus emblica, black seed, myrrh, rosemary, sage, and thyme; some may act as an alternative management option to current treatments for oral conditions such as caries prevention, gingivitis, periodontitis, oral burn, ulcers and inflammation, after extraction, dry mouth, pain reduction, anesthesia, intracanal medications, ill-fitting dentures, peri-implant mucositis and peri-implantitis. It can be used in several forms such as mouthwashes, toothpastes, topical agents or local drug delivery devices. However, more research is needed to understand their mechanisms and potential side effects.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/80839",risUrl:"/chapter/ris/80839",signatures:"Zuhair S. Natto",book:{id:"10827",type:"book",title:"Oral Health Care - An Important Issue of the Modern Society",subtitle:null,fullTitle:"Oral Health Care - An Important Issue of the Modern Society",slug:null,publishedDate:null,bookSignature:"Dr. Lavinia Ardelean and Prof. Laura Cristina Rusu",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-124-1",printIsbn:"978-1-80355-123-4",pdfIsbn:"978-1-80355-125-8",isAvailableForWebshopOrdering:!0,editors:[{id:"180569",title:"Dr.",name:"Lavinia",middleName:null,surname:"Ardelean",slug:"lavinia-ardelean",fullName:"Lavinia Ardelean"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Most common herbs used in dentistry",level:"1"},{id:"sec_2_2",title:"2.1 Aloe Vera",level:"2"},{id:"sec_3_2",title:"2.2 Ginger",level:"2"},{id:"sec_4_2",title:"2.3 Clove",level:"2"},{id:"sec_5_2",title:"2.4 Cinnamon",level:"2"},{id:"sec_6_2",title:"2.5 Garlic",level:"2"},{id:"sec_7_2",title:"2.6 Neem",level:"2"},{id:"sec_8_2",title:"2.7 Miswak",level:"2"},{id:"sec_9_2",title:"2.8 Turmeric",level:"2"},{id:"sec_10_2",title:"2.9 Tulsi",level:"2"},{id:"sec_11_2",title:"2.10 Green tea",level:"2"},{id:"sec_12_2",title:"2.11 Chamomile",level:"2"},{id:"sec_13_2",title:"2.12 Fenugreek",level:"2"},{id:"sec_14_2",title:"2.13 Anise Plant",level:"2"},{id:"sec_15_2",title:"2.14 Peppermint",level:"2"},{id:"sec_16_2",title:"2.15 Bloodroot",level:"2"},{id:"sec_17_2",title:"2.16 Caraway",level:"2"},{id:"sec_18_2",title:"2.17 Eucalyptus",level:"2"},{id:"sec_19_2",title:"2.18 Phyllanthus Emblica",level:"2"},{id:"sec_20_2",title:"2.19 Black seed",level:"2"},{id:"sec_21_2",title:"2.20 Myrrh",level:"2"},{id:"sec_22_2",title:"2.21 Rosemary",level:"2"},{id:"sec_23_2",title:"2.22 Sage",level:"2"},{id:"sec_24_2",title:"2.23 Thyme",level:"2"},{id:"sec_26",title:"3. Conclusions",level:"1"},{id:"sec_30",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Fulzele P, Baliga S, Thosar N, Pradhan D. Evaluation of aloe vera gel as a storage medium in maintaining the viability of periodontal ligament cells-an in vitro study. The Journal of Clinical Pediatric Dentistry. 2016;40(1):49-52. DOI: 10.17796/1053-4628-40.1.49'},{id:"B2",body:'Al-Maweri SA, Nassani MZ, Alaizari N, Kalakonda B, Al-Shamiri HM, Alhajj MN, et al. Efficacy of aloe vera mouthwash versus chlorhexidine on plaque and gingivitis: A systematic review. International Journal of Dental Hygiene. 2020;18(1):44-51. DOI: 10.1111/idh.12393'},{id:"B3",body:'Sayar F, Farahmand AH, Rezazadeh M. Clinical efficacy of aloe vera toothpaste on periodontal parameters of patients with gingivitis-a randomized, controlled, single-masked clinical trial. The Journal of Contemporary Dental Practice. 2021;22(3):242-247'},{id:"B4",body:'Fani M, Kohanteb J. Inhibitory activity of aloe vera gel on some clinically isolated cariogenic and periodontopathic bacteria. Journal of Oral Science. 2012;54(1):15-21. DOI: 10.2334/josnusd.54.15'},{id:"B5",body:'Ghasemi N, Behnezhad M, Asgharzadeh M, Zeinalzadeh E, Kafil HS. Antibacterial properties of aloe vera on intracanal medicaments against Enterococcus faecalis biofilm at different stages of development. International Journal of Dentistry. 2020;2020:8855277. DOI: 10.1155/2020/8855277'},{id:"B6",body:'Rayati F, Hajmanouchehri F, Najafi E. Comparison of anti-inflammatory and analgesic effects of ginger powder and ibuprofen in postsurgical pain model: A randomized, double-blind, case-control clinical trial. Dental Research Journal. 2017;14(1):1-7. DOI: 10.4103/1735-3327.201135'},{id:"B7",body:'Zare Javid A, Bazyar H, Gholinezhad H, Rahimlou M, Rashidi H, Salehi P, et al. The effects of ginger supplementation on inflammatory, antioxidant, and periodontal parameters in type 2 diabetes mellitus patients with chronic periodontitis under non-surgical periodontal therapy. A double-blind, placebo-controlled trial. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2019;12:1751-1761. DOI: 10.2147/DMSO.S214333'},{id:"B8",body:'Rashmi KJ, Tiwari R. Pharmacotherapeutic properties of ginger and its use in diseases of the oral cavity: A narrative review. Journal of Advanced Oral Research. 2016;7:1-6'},{id:"B9",body:'Shrimathi S, Kemparaj U, Umesh S, Karuppaiah M, Pandian P, Krishnaveni A. Comparative evaluation of cocoa bean husk, ginger and chlorhexidine mouth washes in the reduction of steptococcus mutans and lactobacillus count in saliva: A randomized controlled trial. Cureus. 2019;11(6):e4968. DOI: 10.7759/cureus.4968'},{id:"B10",body:'Reisbick MH, Brodsky JF. Strength parameters of composite resins. The Journal of Prosthetic Dentistry. 1971;26(2):178-185. DOI: 10.1016/0022-3913(71)90050-3'},{id:"B11",body:'Grajower R, Hirschfeld Z, Zalkind M. Compatibility of a composite resin with pulp insulating materials. A scanning electron microscope study. The Journal of Prosthetic Dentistry. 1974;32(1):70-77. DOI: 10.1016/0022-3913(74)90101-2'},{id:"B12",body:'Millstein PL, Nathanson D. Effect of eugenol and eugenol cements on cured composite resin. The Journal of Prosthetic Dentistry. 1983;50(2):211-215. DOI: 10.1016/0022-3913(83)90016-1'},{id:"B13",body:'Paige H, Hirsch SM, Gelb MN. Effects of temporary cements on crown-to-composite resin core bond strength. The Journal of Prosthetic Dentistry. 1986;55(1):49-52. DOI: 10.1016/0022-3913(86)90072-7'},{id:"B14",body:'Marya CM, Satija G, Avinash J, Nagpal R, Kapoor R, Ahmad A. In vitro inhibitory effect of clove essential oil and its two active principles on tooth decalcification by apple juice. International Journal of Dentistry. 2012;2012:759618. DOI: 10.1155/2012/759618'},{id:"B15",body:'Alqareer A, Alyahya A, Andersson L. The effect of clove and benzocaine versus placebo as topical anesthetics. Journal of Dentistry. 2006;34(10):747-750. DOI: 10.1016/j.jdent.2006.01.009'},{id:"B16",body:'Uju DE, Obioma NP. Anticariogenic potentials of clove, tobacco and bitter kola. Asian Pacific Journal of Tropical Medicine. 2011;4(10):814-818. DOI: 10.1016/S1995-7645(11)60200-9'},{id:"B17",body:'Panchal V, Gurunathan D, Muralidharan NP. Comparison of antibacterial efficacy of cinnamon extract, neem extract as irrigant and sodium hypochlorite against Enterococcus fecalis: An in vitro study. Indian Journal of Dental Research. 2020;31(1):124-128. DOI: 10.4103/ijdr.IJDR_177_18'},{id:"B18",body:'Wiwattanarattanabut K, Choonharuangdej S, Srithavaj T. In vitro anti-cariogenic plaque effects of essential oils extracted from culinary herbs. Journal of Clinical and Diagnostic Research. 2017;11:DC30-DC35. DOI: 10.7860/JCDR/2017/28327.10668'},{id:"B19",body:'Zhu M, Carvalho R, Scher A, Wu CD. Short-term germ-killing effect of sugar-sweetened cinnamon chewing gum on salivary anaerobes associated with halitosis. The Journal of Clinical Dentistry. 2011;22(1):23-26'},{id:"B20",body:'Saquib SA, AlQahtani NA, Ahmad I, Kader MA, Al Shahrani SS, Asiri EA. Evaluation and comparison of antibacterial efficacy of herbal extracts in combination with antibiotics on periodontal pathobionts: An in vitro microbiological study. Antibiotics. 2019;8(3):89. DOI: 10.3390/antibiotics8030089'},{id:"B21",body:'Mamajiwala AS, Sethi KS, Raut CP, Karde PA, Khedkar SU. Comparative evaluation of chlorhexidine and cinnamon extract used in dental unit waterlines to reduce bacterial load in aerosols during ultrasonic scaling. Indian Journal of Dental Research. 2018;29(6):749-754. DOI: 10.4103/ijdr.IJDR_571_17'},{id:"B22",body:'Bakri IM, Douglas CW. Inhibitory effect of garlic extract on oral bacteria. Archives of Oral Biology. 2005;50:645-651. DOI: 10.1016/j.archoralbio.2004.12.002'},{id:"B23",body:'Bachrach G, Jamil A, Naor R, Tal G, Ludmer Z, Steinberg D. Garlic allicin as a potential agent for controlling oral pathogens. Journal of Medicinal Food. 2011;14:1338-1343. DOI: 10.1089/jmf.2010.0165'},{id:"B24",body:'Velliyagounder K, Ganeshnarayan K, Velusamy SK, Fine DH. In vitro efficacy of diallyl sulfides against the periodontopathogen Aggregatibacter actinomycetemcomitans. Antimicrobial Agents and Chemotherapy. 2012;56:2397-2407. DOI: 10.1128/AAC.00020-12'},{id:"B25",body:'Elheeny AAH. Allium sativum extract as an irrigant in pulpectomy of primary molars: A 12-month short-term evaluation. Clinical and Experimental Dental Research. 2019;5(4):420-426. DOI: 10.1002/cre2.197'},{id:"B26",body:'Kshirsagar MM, Dodamani AS, Karibasappa GN, Vishwakarma PK, Vathar JB, Sonawane KR, et al. Antibacterial activity of garlic extract on cariogenic bacteria: An in vitro study. Ayu. 2018;39(3):165-168. DOI: 10.4103/ayu.AYU_193_16'},{id:"B27",body:'Momeni R, Hosseini Z, Aghamolaei T, Ghanbarnejad A. Determinants factors to pap smear screening among married women in a city of South Iran: Applying the BASNEF model. BMC Women\'s Health. 2020;20(1):237. DOI: 10.1186/s12905-020-01102-6'},{id:"B28",body:'Vennila K, Elanchezhiyan S, Ilavarasu S. Efficacy of 10% whole Azadirachta indica (neem) chip as an adjunct to scaling and root planning in chronic periodontitis: A clinical and microbiological study. Indian Journal of Dental Research. 2016;27(1):15-21. DOI: 10.4103/0970-9290.179808'},{id:"B29",body:'Morris J, Gonzales CB, De La Chapa JJ, Cabang AB, Fountzilas C, Patel M, et al. The highly pure neem leaf extract, SCNE, inhibits tumorigenesis in oral squamous cell carcinoma via disruption of pro-tumor inflammatory cytokines and cell Signaling. Frontiers in Oncology. 2019;9:890. DOI: 10.3389/fonc.2019.00890'},{id:"B30",body:'Niazi FH, Kamran MA, Naseem M, AlShahrani I, Fraz TR, Hosein M. Anti-plaque efficacy of herbal mouthwashes compared to synthetic mouthwashes in patients undergoing orthodontic treatment: A randomised controlled trial. Oral Health & Preventive Dentistry. 2018;16(5):409-416. DOI: 10.3290/j.ohpd.a40983'},{id:"B31",body:'Ahmad H. Biological activities of Salvadora persica L. (Meswak). Medicinal & Aromatic Plants. 2017;2:129. DOI: 10.4172/2167-0412.1000129'},{id:"B32",body:'Kaur S, Abdul Jalil R, Akmar SL. The immediate term effect of chewing commercially available Meswak (Salvadora Persica) on levels of calcium, chloride, phosphate and thiocyanate in whole saliva. Annals of Dentistry. 2004;11(1):51-59. DOI: 10.22452/adum.vol11no1.8'},{id:"B33",body:'Gupta P, Agarwal N, Anup N, Manujunath BC, Bhalla A. Evaluating the anti-plaque efficacy of meswak (Salvadora persica) containing dentifrice: A triple blind controlled trial. Journal of Pharmacy & Bioallied Sciences. 2012;4(4):282-285. DOI: 10.4103/0975-7406.103238'},{id:"B34",body:'Sekar S, Jacob S, Suthanthiran TK, Dhasthaheer S, Vikraman S, Kaliappan K. Characterization and formulation of Miswak film for the treatment of chronic periodontitis: An in vitro study. Journal of Pharmacy & Bioallied Sciences. 2020;12(Suppl 1):S199-S203. DOI: 10.4103/jpbs.JPBS_59_20'},{id:"B35",body:'Nordin A, Bin Saim A, Ramli R, Abdul Hamid A, Mohd Nasri NW, Bt Hj Idrus R. Miswak and oral health: An evidence-based review. Saudi Journal of Biological Sciences. 2020;27(7):1801-1810. DOI: 10.1016/j.sjbs.2020.05.020'},{id:"B36",body:'Forouzanfar F, Forouzanfar A, Sathyapalan T, Orafai HM, Sahebkar A. Curcumin for the management of periodontal diseases: A review. Current Pharmaceutical Design. 2020;26(34):4277-4284. DOI: 10.2174/1381612826666200513112607'},{id:"B37",body:'Nurdiana N, Krishnasamy S. Effect of two percent turmeric extract gel on minor recurrent aphthous stomatitis. Padjadjaran Journal of Dentistry. 2016;28(1):1-6. DOI: 10.24198/pjd.vol28no1.13503'},{id:"B38",body:'Lolayekar NV, Kadkhodayan SS. Estimation of salivary pH and viability of Streptococcus mutans on chewing of tulsi leaves in children. Journal of the Indian Society of Pedodontics and Preventive Dentistry. 2019;37(1):87-91. DOI: 10.4103/JISPPD.JISPPD_91_17'},{id:"B39",body:'Ahmed SV, Reddy CS, Kudlure SM, Gomasani S. Effect of tulsi extract and honey mouthrinses on salivary Streptococcus mutans count in comparison with 0.2% of chlorhexidine: A randomized controlled trial. Journal of Indian Association of Public Health Dentistry. 2017;15(4):306-311. DOI: 10.4103/jiaphd.jiaphd_55_17'},{id:"B40",body:'Mallikarjun S, Rao A, Rajesh G, Shenoy R, Pai M. Antimicrobial efficacy of tulsi leaf (Ocimum sanctum) extract on periodontal pathogens: An in vitro study. Journal of Indian Society of Periodontology. 2016;20(2):145-150. DOI: 10.4103/0972-124X.175177'},{id:"B41",body:'Vargas-Sanchez PK, Pitol DL, de Sousa LG, Beloti MM, Rosa AL, Rossi AC, et al. Green tea extract rich in epigallocatechin gallate impairs alveolar bone loss in ovariectomized rats with experimental periodontal disease. International Journal of Experimental Pathology. 2020;101(6):277-288. DOI: 10.1111/iep.12379'},{id:"B42",body:'Venkateswara B, Sirisha K, Chava VK. Green tea extract for periodontal health. Journal of Indian Society of Periodontology. 2011;15(1):18-22. DOI: 10.4103/0972-124X.82258'},{id:"B43",body:'Taheri JB, Azimi S, Rafieian N, Zanjani HA. Herbs in dentistry. International Dental Journal. 2011;61(6):287-296. DOI: 10.1111/j.1875-595X.2011.00064.x'},{id:"B44",body:'Hans VM, Grover HS, Deswal H, Agarwal P. Antimicrobial efficacy of various essential oils at varying concentrations against Periopathogen Porphyromonas gingivalis. Journal of Clinical and Diagnostic Research. 2016;10(9):ZC16-ZC19'},{id:"B45",body:'Aitken-Saavedra J, Chaves Tarquinio SB, De Oliveira da Rosa WL, Fernandes da Silva A, Almeida Machado BM, Santos Castro I, et al. Effect of a homemade salivary substitute prepared using chamomile (Matricaria chamomilla L.) flower and flax (Linum usitatissimum L.) seed to relieve primary burning mouth syndrome: A preliminary report. Journal of Alternative and Complementary Medicine. 2020;26(9):799-806. DOI: 10.1089/acm.2019.0478'},{id:"B46",body:'Venkataram V, Gokhale ST, Kenchappa M, Nagarajappa R. Effectiveness of chamomile (Matricaria recutita L.), MTAD and sodium hypochlorite irrigants on smear layer. European Archives of Paediatric Dentistry. 2013;14(4):247-252. DOI: 10.1007/s40368-013-0062-3'},{id:"B47",body:'Sundaram G, Ramakrishnan T, Parthasarathy H, Raja M, Raj S. Fenugreek, diabetes, and periodontal disease: A cross-link of sorts! Journal of Indian Society of Periodontology. 2018;22(2):122-126. DOI: 10.4103/jisp.jisp_322_17'},{id:"B48",body:'Ashrafi B, Rashidipour M, Marzban A, Soroush S, Azadpour M, Delfani S, et al. Mentha piperita essential oils loaded in a chitosan nanogel with inhibitory effect on biofilm formation against S. mutans on the dental surface. Carbohydrate Polymers. 2019;212:142-149. DOI: 10.1016/j.carbpol.2019.02.018'},{id:"B49",body:'Bankur PK, Mathew M, Almalki SA, Jalaluddin M, Jayanti I, Durgaraju M. An in vitro evaluation of antibacterial efficacy of various concentration of eucalyptus globulus leaf extract on periodontal pathogens. The Journal of Contemporary Dental Practice. 2019;20(9):1041-1044'},{id:"B50",body:'Yap PS, Lim SH, Hu CP, Yiap BC. Combination of essential oils and antibiotics reduce antibiotic resistance in plasmid-conferred multidrug resistant bacteria. Phytomedicine. 2013;20(8-9):710-713. DOI: 10.1016/j.phymed.2013.02.013'},{id:"B51",body:'Yadav HK, Yadav RK, Chandra A, Thakkar RR. The effectiveness of eucalyptus oil, orange oil, and xylene in dissolving different endodontic sealers. Journal of Conservative Dentistry. 2016;19(4):332-337. DOI: 10.4103/0972-0707.186447'},{id:"B52",body:'Grover S, Tewari S, Sharma RK, Singh G, Yadav A, Naula SC. Effect of subgingivally delivered 10% emblica officinalis gel as an adjunct to scaling and root planning in the treatment of chronic periodontitis - a randomized placebo-controlled clinical trial. Phytotherapy Research. 2016;30(6):956-962. DOI: 10.1002/ptr.5600'},{id:"B53",body:'Thaweboon B, Thaweboon S. Effect of Phyllanthus emblica Linn. On candida adhesion to oral epithelium and denture acrylic. Asian Pacific Journal of Tropical Medicine. 2011;4(1):41-45. DOI: 10.1016/S1995-7645(11)60029-1'},{id:"B54",body:'Mekhemar M, Hassan Y, Dörfer C. Nigella sativa and thymoquinone: A natural blessing for periodontal therapy. Antioxidants. 2020;9(12):1260. DOI: 10.3390/antiox9121260'},{id:"B55",body:'Tada A, Nakayama-Imaohji H, Yamasaki H, Elahi M, Nagao T, Yagi H, et al. Effect of thymoquinone on fusobacterium nucleatum-associated biofilm and inflammation. Molecular Medicine Reports. 2020;22(2):643-650. DOI: 10.3892/mmr.2020.11136'},{id:"B56",body:'ALHarthi SSY, Natto ZS, Midle JB, Gyurko R, O\'Neill R, Steffensen B. Association between time since quitting smoking and periodontitis in former smokers in the National Health and Nutrition Examination Surveys (NHANES) 2009 to 2012. Journal of Periodontology. 2019;90(1):16-25. DOI: 10.1002/JPER.18-0183'},{id:"B57",body:'Alshaeri HK, Natto ZS. A contemporary look at COVID-19 medications: Available and potentially effective drugs. European Review for Medical and Pharmacological Sciences. 2020;24(17):9188-9195. DOI: 10.26355/eurrev_202009_22870'},{id:"B58",body:'Alshaeri HK, Alasmari MM, Natto ZS, Pino-Figueroa A. Effects of annona muricata extract on triple-negative breast cancer cells mediated through EGFR signaling. Cancer Management and Research. 2020;12:12519-12526. DOI: 10.2147/CMAR.S278647'},{id:"B59",body:'Shalaby MA, Hammouda AA. Analgesic, anti-inflammatory and anti-hyperlipidemic activities of commiphora molmol extract (myrrh). Journal of Intercultural Ethnopharmacology. 2014;3(2):56-62'},{id:"B60",body:'El Ashry ES, Rashed N, Salama OM, Saleh A. Components, therapeutic value and uses of myrrh. Pharmazie. 2003;58(3):163-168'},{id:"B61",body:'Mansour G, Ouda S, Shaker A, Abdallah HM. Clinical efficacy of new aloe vera and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: A randomized, double-blind, vehicle-controlled study. Journal of Oral Pathology & Medicine. 2014;43(6):405-409'},{id:"B62",body:'Al-Mobeeriek A. Effects of myrrh on intra-oral mucosal wounds compared with tetracycline and chlorhexidine-based mouthwashes. Clinical, Cosmetic and Investigational Dentistry. 2011;3:53-58'},{id:"B63",body:'Almekhlafi STA, Alwossabi AM, Awadth N, Thabet AA, Algaadari Z. Antimicrobial activity of Yemeni myrrh mouthwash. Journal of Chemical and Pharmaceutical Research. 2014;6(5):1006-1013'},{id:"B64",body:'Kariuki HMAH, Wagaiyu EG. Effect of a natural extract toothpaste on the bacteria colonies of initial dental plaque colonizers. IOSR Journal of Dental and Medical Sciences. 2017;16(9):13-21'},{id:"B65",body:'Bassiouny G, Al-Barrak H. The anti-plaque effect of miswak and myrrh mouthwashes versus chlorhexidine in the treatment of chronic gingivitis; A comparative clinical trial. Medical Science. 2014;9(33):32-37'},{id:"B66",body:'Min-Sun Kim G-SB, Park K-C, et al. Myrrh inhibits LPS-induced inflammatory response and protects from cecal ligation and puncture-induced sepsis. Evidence-based Complementary and Alternative Medicine. 2012;2012:11'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Zuhair S. Natto",address:"znatto@kau.edu.sa",affiliation:'
Faculty of Dentistry, Department of Dental Public Health, King Abdulaziz University, Jeddah, Saudi Arabia
'}],corrections:null},book:{id:"10827",type:"book",title:"Oral Health Care - An Important Issue of the Modern Society",subtitle:null,fullTitle:"Oral Health Care - An Important Issue of the Modern Society",slug:null,publishedDate:null,bookSignature:"Dr. Lavinia Ardelean and Prof. Laura Cristina Rusu",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-124-1",printIsbn:"978-1-80355-123-4",pdfIsbn:"978-1-80355-125-8",isAvailableForWebshopOrdering:!0,editors:[{id:"180569",title:"Dr.",name:"Lavinia",middleName:null,surname:"Ardelean",slug:"lavinia-ardelean",fullName:"Lavinia Ardelean"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"191532",title:"Dr.",name:"Erin S.",middleName:null,surname:"Barry",email:"erin.barry.ctr@usuhs.edu",fullName:"Erin S. Barry",slug:"erin-s.-barry",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"3",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:{name:"Uniformed Services University of the Health Sciences",institutionURL:null,country:{name:"United States of America"}}},booksEdited:[],chaptersAuthored:[{id:"52503",title:"Gender and Leadership",slug:"gender-and-leadership",abstract:"The topic of leadership has been addressed and applied for millennia. Yet, it is only within the past 80 years that leadership has been a topic of serious discussion. It is important to understand variables relevant to effective leadership. Gender is one such variable that must be examined with regard to optimizing leadership effectiveness. The topic of gender and leadership deserves serious and thoughtful consideration and discussion because of professional, political, cultural, and personal realities of the twenty‐first century. Women and men have been, are, and should be leaders. Gender must be considered to determine how each leader can reach maximum potential and effectiveness. The FourCe‐PITO conceptual framework of leadership is designed to help guide leadership development and education. The present chapter uses this conceptual framework of leadership to discuss how consideration of gender may affect and optimize leadership development and effectiveness. It is the goal of this chapter to lay out the issues that educators of leaders, potential leaders, and “practicing” leaders should be aware of, to achieve success for the good of the groups and individuals they have the responsibility to lead.",signatures:"Kathryn E. Eklund, Erin S. Barry and Neil E. Grunberg",authors:[{id:"191531",title:"Dr.",name:"Neil E.",surname:"Grunberg",fullName:"Neil E. Grunberg",slug:"neil-e.-grunberg",email:"neil.grunberg@usuhs.edu"},{id:"191532",title:"Dr.",name:"Erin S.",surname:"Barry",fullName:"Erin S. Barry",slug:"erin-s.-barry",email:"erin.barry.ctr@usuhs.edu"},{id:"191533",title:"Ph.D. Student",name:"Kathryn",surname:"Eklund",fullName:"Kathryn Eklund",slug:"kathryn-eklund",email:"kathryn.eklund@usuhs.edu"}],book:{id:"5472",title:"Gender Differences in Different Contexts",slug:"gender-differences-in-different-contexts",productType:{id:"1",title:"Edited Volume"}}},{id:"78442",title:"Optimizing Innovative Leadership and Followership",slug:"optimizing-innovative-leadership-and-followership",abstract:"Leadership and followership development are increasingly recognized as important in all fields of the workforce. The Innovative Leadership Model helps leaders increase self-understanding and optimize the performance of organizations by focusing on Leader Type, Developmental Perspective, Resilience, Situational Analysis, and Leadership Behaviors and Mindsets. The Leader-Follower Framework identifies key elements – Character, Competence, Communication, Context – to guide the development of individual leaders and followers across four psychosocial levels – Personal, Interpersonal, Team, Organizational. Each of these approaches has value and has been applied in various settings and contexts. The present chapter offers a new insight relevant to leadership by combining these two perspectives and their component elements. Understanding and developing each of these elements will optimize effective leadership and followership in a wide range of situations and settings.",signatures:"Neil E. Grunberg, Erin S. Barry, Michael Morrow-Fox and Maureen Metcalf",authors:[{id:"191531",title:"Dr.",name:"Neil E.",surname:"Grunberg",fullName:"Neil E. Grunberg",slug:"neil-e.-grunberg",email:"neil.grunberg@usuhs.edu"},{id:"191532",title:"Dr.",name:"Erin S.",surname:"Barry",fullName:"Erin S. Barry",slug:"erin-s.-barry",email:"erin.barry.ctr@usuhs.edu"},{id:"421261",title:"Ms.",name:"Maureen",surname:"Metcalf",fullName:"Maureen Metcalf",slug:"maureen-metcalf",email:"mmetcalf@innovateleader.com"},{id:"421262",title:"Mr.",name:"Michael",surname:"Morrow-Fox",fullName:"Michael Morrow-Fox",slug:"michael-morrow-fox",email:"mikemorrowfox@gmail.com"}],book:{id:"10915",title:"Leadership",slug:"leadership-new-insights",productType:{id:"1",title:"Edited Volume"}}},{id:"82888",title:"From Empathy to the Aggression–Compassion Continuum",slug:"from-empathy-to-the-aggression-compassion-continuum",abstract:"Empathy is relevant to but not sufficient to fully understand relationships. Recent research has proposed that empathy is part of a continuum—from pity to sympathy to empathy to compassion—and that compassion is the key to building good relationships because it includes actions. We offer an extension of this concept to include neutrality (apathy) and add four constructs of opposition—from antipathy to animosity to hostility to aggression. We describe all nine constructs with regard to cognitive, emotional, and behavioral support or opposition. Further, we propose that it is useful to consider these constructs in terms of character, competence, context, and communication at four psychosocial levels—personal, interpersonal, team, and organizational. We believe that relationships can be best addressed with these concepts in mind and that application of the support versus oppose poles of the aggression-compassion continuum are not equivalent to good and bad.",signatures:"Neil E. Grunberg and Erin S. Barry",authors:[{id:"191531",title:"Dr.",name:"Neil E.",surname:"Grunberg",fullName:"Neil E. Grunberg",slug:"neil-e.-grunberg",email:"neil.grunberg@usuhs.edu"},{id:"191532",title:"Dr.",name:"Erin S.",surname:"Barry",fullName:"Erin S. Barry",slug:"erin-s.-barry",email:"erin.barry.ctr@usuhs.edu"}],book:{id:"11443",title:"Empathy - Advanced Research and Applications",slug:null,productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"189599",title:"Associate Prof.",name:"Breno",surname:"Cruz",slug:"breno-cruz",fullName:"Breno Cruz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/189599/images/4557_n.jpg",biography:"Dr. Breno de Paula Andrade Cruz is professor at Federal Rural University of Rio de Janeiro (UFRRJ) teaching on Master\\'s and bachelor courses.",institutionString:null,institution:{name:"Universidade Federal Rural do Rio de Janeiro",institutionURL:null,country:{name:"Brazil"}}},{id:"189600",title:"Mr.",name:"Ricardo",surname:"Pires-Júnior",slug:"ricardo-pires-junior",fullName:"Ricardo Pires-Júnior",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/189600/images/4560_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Veiga de Almeida",institutionURL:null,country:{name:"Brazil"}}},{id:"189601",title:"Dr.",name:"Steven",surname:"Dutt Ross",slug:"steven-dutt-ross",fullName:"Steven Dutt Ross",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Rio de Janeiro",institutionURL:null,country:{name:"Brazil"}}},{id:"190853",title:"Dr.",name:"Tom",surname:"Dobson",slug:"tom-dobson",fullName:"Tom Dobson",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190853/images/5923_n.jpg",biography:null,institutionString:null,institution:{name:"Leeds Beckett University",institutionURL:null,country:{name:"United Kingdom"}}},{id:"190985",title:"Dr.",name:"Xifu",surname:"Zheng",slug:"xifu-zheng",fullName:"Xifu Zheng",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"South China Normal University",institutionURL:null,country:{name:"China"}}},{id:"194981",title:"BSc.",name:"Yonghui",surname:"Zhu",slug:"yonghui-zhu",fullName:"Yonghui Zhu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"South China Normal University",institutionURL:null,country:{name:"China"}}},{id:"194982",title:"MSc.",name:"Wenqing",surname:"Wang",slug:"wenqing-wang",fullName:"Wenqing Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"South China Normal University",institutionURL:null,country:{name:"China"}}},{id:"194985",title:"Dr.",name:"Jingchu",surname:"Hu",slug:"jingchu-hu",fullName:"Jingchu Hu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"South China Normal University",institutionURL:null,country:{name:"China"}}},{id:"194986",title:"MSc.",name:"Biao",surname:"Feng",slug:"biao-feng",fullName:"Biao Feng",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"South China Normal University",institutionURL:null,country:{name:"China"}}},{id:"194987",title:"Ph.D. Student",name:"Jiawei",surname:"Xie",slug:"jiawei-xie",fullName:"Jiawei Xie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/194987/images/16397_n.jpg",biography:null,institutionString:null,institution:{name:"South China Normal University",institutionURL:null,country:{name:"China"}}}]},generic:{page:{slug:"cro-terms-and-conditions",title:"Odredbe i uvjeti",intro:'
Ove Odredbe i uvjeti ističu pravila i regulacije u svezi korištenja IntechOpenove stranice www.intechopen.com i svih poddomena u vlasništvu IntechOpena, tvrtke sa sjedištem u 5 Princes Gate Court, London, SW7 2QJ, Ujedinjeno Kraljevstvo.
',metaTitle:"Odredbe i uvjeti",metaDescription:"Ove Odredbe i uvjeti ističu pravila i regulacije u svezi korištenja IntechOpenove stranice www.intechopen.com i svih poddomena u vlasništvu IntechOpena, tvrtke sa sjedištem u 5 Princes Gate Court, London, SW7 2QJ, Ujedinjeno Kraljevstvo.",metaKeywords:null,canonicalURL:"/page/cro-terms-and-conditions",contentRaw:'[{"type":"htmlEditorComponent","content":"
1. Odredbe
\\n\\n
Pristupom na stranicu www.intechopen.com slažete se s ovim odredbama, sa svim primjenjivim zakonskim odredbama, te se slažete s poštovanjem svih lokalnih zakona. Korištenje i/ili pristup ovoj stranici temelji se na potpunom prihvaćanju ovih odredbi. Svi materijali na ovoj stranici zaštićeni su primjenjivim zakonima o autorskim pravima i žigu.
\\n\\n
Sljedeća terminologija odnosi se na Odredbe i uvjete, te na sve naše ugovore:
\\n\\n
Klijent, stranka, vi, vaš odnosi se na vas, osobu koja pristupa ovoj stranici i prihvaća IntechOpenove Odredbe i uvjete;
\\n\\n
Kompanija, tvrtka, mi, naše odnosi se na tvrtku IntechOpen;
\\n\\n
Stranke, strane odnosi se na klijenta i na nas, ili samo na klijenta ili nas.
\\n\\n
Sve odredbe koje se odnose na ponudu, prihvat ili razmatranje plaćanja, a za koja mi pružamo asistenciju klijentu, bilo na ugovoreni ili fiksni način, a s ciljem da se ostvare potrebe i želje klijenta u svezi s našim uslugama, su podložne zakonskim odredbama Ujedinjenog Kraljevstva.
\\n\\n
2. Licenca
\\n\\n
Osim ako nije suprotno navedeno, IntechOpen i/ili svi davatelji licence vlasnici su intelektualnog vlasništva nad svim materijalima na www.intechopen.com. Sva prava intelektualnog vlasništva su pridržana. Stranice sa www.intechopen.com možete gledati, preuzimati, dijeliti, dijeliti poveznice i printati za osobnu uporabu, a temeljem pravila sadržanih u ovim Odredbama i uvjetima.
\\n\\n
3. Kolačići
\\n\\n
Mi koristimo kolačiće. Korištenjem IntechOpenove stranice slažete se s korištenjem kolačića u skladu s IntechOpenovom Politikom privatnosti. Većina modernih, interaktivnih stranica koristi kolačiće kako bi omogućila ponovno pronalaženje korisničkih detalja kod svakog posjeta. Na našoj stranici kolačići se uglavnom koriste kako bi omogućili funkcionalnost i olakšali posjetiteljima korištenje stranice.
\\n\\n
4. Ograničenja odgovornosti
\\n\\n
IntechOpen ili njegovi suradnici niti u jednom slučaju neće biti odgovorni za štete (štete uključuju gubitak podataka ili profita, druge poslovne prekide, te sve ostale štete) koje nastanu zbog korištenja materijala na IntechOpenovoj stranici ili nemogućnosti da se iste koriste, čak i ako je IntechOpen ili njegov predstavnik o takvoj šteti obaviješten pismenim ili usmenim putem. Neke jurisdikcije ne dozvoljavaju ograničenja garancija ili ograničenja obveza za posljedične ili slučajne štete pa se u tom slučaju ova ograničenja možda ne odnose na vas.
\\n\\n
5. Točnost materijala
\\n\\n
Materijali koji se pojavljuju na IntechOpenovoj stranici mogu sadržavati manje greške, tipfelere ili fotografske greške. IntechOpen može napraviti promjene na bilo kojem materijalu koji se nalazi na stranici u bilo koje vrijeme.
\\n\\n
6. Poveznice
\\n\\n
IntechOpen nije formalno povezan niti s jednom vanjskom stranicom čije poveznice vode na www.intechopen.com, osim ako to nije izravno navedeno. Iz tog razloga IntechOpen nije odgovoran za sadržaj koji se pojavljuje na takvim stranicama. Poveznica na IntechOpenovu stranicu ne implicira povezanost sa IntechOpenom. Korištenje takvih poveznica isključiva je odgovornost korisnika.
\\n\\n
Zadržavamo pravo vlasništva nad cjelokupnom stranicom www.intechopen.com i nad svim materijalom na toj stranici. Koristeći se našim uslugama, slažete se da maknete sve poveznice na našu stranicu odmah nakon što to od vas zatražimo. Također, zadržavamo pravo da ove Odredbe i uvjete, i politiku o poveznicama izmjenimo u bilo koje vrijeme. Koristeći se poveznicama na naše stranice slažete se s ovim Odredbama i uvjetima.
\\n\\n
Ako smatrate da je bilo koja poveznica na našoj stranici sumnjiva iz bilo kojeg razloga, molimo vas da nas kontaktirate. U tom slučaju razmotrit ćemo micanje poveznice s naše stranice, iako nismo obvezni to napraviti.
\\n\\n
7. Okviri (Frames)
\\n\\n
Bez prethodne privole i izričite pisane dozvole, ne možete stvarati okvire oko naših stranica ili koristiti druge tehnike koje na bilo koji način mogu promijeniti prezentaciju ili izgled naše stranice.
\\n\\n
8. Promjene
\\n\\n
IntechOpen može ove Odredbe izmijeniti u bilo koje vrijeme i bez prethodne obavijesti. Koristeći ovu stranicu vi se slažete s trenutnim Odredbama i uvjetima koje su na snazi.
\\n\\n
9. Nadležno pravo
\\n\\n
Ove Odredbe i uvjeti su sastavljeni u skladu s odredbama prava Ujedinjenog Kraljevstva, a za sve sporove nadležan je sud u Londonu, Ujedinjeno Kraljevstvo.
Pristupom na stranicu www.intechopen.com slažete se s ovim odredbama, sa svim primjenjivim zakonskim odredbama, te se slažete s poštovanjem svih lokalnih zakona. Korištenje i/ili pristup ovoj stranici temelji se na potpunom prihvaćanju ovih odredbi. Svi materijali na ovoj stranici zaštićeni su primjenjivim zakonima o autorskim pravima i žigu.
\n\n
Sljedeća terminologija odnosi se na Odredbe i uvjete, te na sve naše ugovore:
\n\n
Klijent, stranka, vi, vaš odnosi se na vas, osobu koja pristupa ovoj stranici i prihvaća IntechOpenove Odredbe i uvjete;
\n\n
Kompanija, tvrtka, mi, naše odnosi se na tvrtku IntechOpen;
\n\n
Stranke, strane odnosi se na klijenta i na nas, ili samo na klijenta ili nas.
\n\n
Sve odredbe koje se odnose na ponudu, prihvat ili razmatranje plaćanja, a za koja mi pružamo asistenciju klijentu, bilo na ugovoreni ili fiksni način, a s ciljem da se ostvare potrebe i želje klijenta u svezi s našim uslugama, su podložne zakonskim odredbama Ujedinjenog Kraljevstva.
\n\n
2. Licenca
\n\n
Osim ako nije suprotno navedeno, IntechOpen i/ili svi davatelji licence vlasnici su intelektualnog vlasništva nad svim materijalima na www.intechopen.com. Sva prava intelektualnog vlasništva su pridržana. Stranice sa www.intechopen.com možete gledati, preuzimati, dijeliti, dijeliti poveznice i printati za osobnu uporabu, a temeljem pravila sadržanih u ovim Odredbama i uvjetima.
\n\n
3. Kolačići
\n\n
Mi koristimo kolačiće. Korištenjem IntechOpenove stranice slažete se s korištenjem kolačića u skladu s IntechOpenovom Politikom privatnosti. Većina modernih, interaktivnih stranica koristi kolačiće kako bi omogućila ponovno pronalaženje korisničkih detalja kod svakog posjeta. Na našoj stranici kolačići se uglavnom koriste kako bi omogućili funkcionalnost i olakšali posjetiteljima korištenje stranice.
\n\n
4. Ograničenja odgovornosti
\n\n
IntechOpen ili njegovi suradnici niti u jednom slučaju neće biti odgovorni za štete (štete uključuju gubitak podataka ili profita, druge poslovne prekide, te sve ostale štete) koje nastanu zbog korištenja materijala na IntechOpenovoj stranici ili nemogućnosti da se iste koriste, čak i ako je IntechOpen ili njegov predstavnik o takvoj šteti obaviješten pismenim ili usmenim putem. Neke jurisdikcije ne dozvoljavaju ograničenja garancija ili ograničenja obveza za posljedične ili slučajne štete pa se u tom slučaju ova ograničenja možda ne odnose na vas.
\n\n
5. Točnost materijala
\n\n
Materijali koji se pojavljuju na IntechOpenovoj stranici mogu sadržavati manje greške, tipfelere ili fotografske greške. IntechOpen može napraviti promjene na bilo kojem materijalu koji se nalazi na stranici u bilo koje vrijeme.
\n\n
6. Poveznice
\n\n
IntechOpen nije formalno povezan niti s jednom vanjskom stranicom čije poveznice vode na www.intechopen.com, osim ako to nije izravno navedeno. Iz tog razloga IntechOpen nije odgovoran za sadržaj koji se pojavljuje na takvim stranicama. Poveznica na IntechOpenovu stranicu ne implicira povezanost sa IntechOpenom. Korištenje takvih poveznica isključiva je odgovornost korisnika.
\n\n
Zadržavamo pravo vlasništva nad cjelokupnom stranicom www.intechopen.com i nad svim materijalom na toj stranici. Koristeći se našim uslugama, slažete se da maknete sve poveznice na našu stranicu odmah nakon što to od vas zatražimo. Također, zadržavamo pravo da ove Odredbe i uvjete, i politiku o poveznicama izmjenimo u bilo koje vrijeme. Koristeći se poveznicama na naše stranice slažete se s ovim Odredbama i uvjetima.
\n\n
Ako smatrate da je bilo koja poveznica na našoj stranici sumnjiva iz bilo kojeg razloga, molimo vas da nas kontaktirate. U tom slučaju razmotrit ćemo micanje poveznice s naše stranice, iako nismo obvezni to napraviti.
\n\n
7. Okviri (Frames)
\n\n
Bez prethodne privole i izričite pisane dozvole, ne možete stvarati okvire oko naših stranica ili koristiti druge tehnike koje na bilo koji način mogu promijeniti prezentaciju ili izgled naše stranice.
\n\n
8. Promjene
\n\n
IntechOpen može ove Odredbe izmijeniti u bilo koje vrijeme i bez prethodne obavijesti. Koristeći ovu stranicu vi se slažete s trenutnim Odredbama i uvjetima koje su na snazi.
\n\n
9. Nadležno pravo
\n\n
Ove Odredbe i uvjeti su sastavljeni u skladu s odredbama prava Ujedinjenog Kraljevstva, a za sve sporove nadležan je sud u Londonu, Ujedinjeno Kraljevstvo.
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. 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Watt",authors:[{id:"145620",title:"Dr.",name:"Gina",middleName:null,surname:"Forster",slug:"gina-forster",fullName:"Gina Forster"},{id:"146553",title:"BSc.",name:"Andrew",middleName:null,surname:"Novick",slug:"andrew-novick",fullName:"Andrew Novick"},{id:"146554",title:"MSc.",name:"Jamie",middleName:null,surname:"Scholl",slug:"jamie-scholl",fullName:"Jamie Scholl"},{id:"146555",title:"Dr.",name:"Michael",middleName:null,surname:"Watt",slug:"michael-watt",fullName:"Michael Watt"}]},{id:"26258",doi:"10.5772/28300",title:"Excitotoxicity and Oxidative Stress in Acute Ischemic Stroke",slug:"excitotoxicity-and-oxidative-stress-in-acute-ischemic-stroke",totalDownloads:7206,totalCrossrefCites:6,totalDimensionsCites:27,abstract:null,book:{id:"931",slug:"acute-ischemic-stroke",title:"Acute Ischemic Stroke",fullTitle:"Acute Ischemic Stroke"},signatures:"Ramón Rama Bretón and Julio César García Rodríguez",authors:[{id:"73430",title:"Prof.",name:"Ramon",middleName:null,surname:"Rama",slug:"ramon-rama",fullName:"Ramon Rama"},{id:"124643",title:"Prof.",name:"Julio Cesar",middleName:null,surname:"García",slug:"julio-cesar-garcia",fullName:"Julio Cesar García"}]},{id:"62072",doi:"10.5772/intechopen.78695",title:"Brain-Computer Interface and Motor Imagery Training: The Role of Visual Feedback and Embodiment",slug:"brain-computer-interface-and-motor-imagery-training-the-role-of-visual-feedback-and-embodiment",totalDownloads:1473,totalCrossrefCites:13,totalDimensionsCites:25,abstract:"Controlling a brain-computer interface (BCI) is a difficult task that requires extensive training. Particularly in the case of motor imagery BCIs, users may need several training sessions before they learn how to generate desired brain activity and reach an acceptable performance. A typical training protocol for such BCIs includes execution of a motor imagery task by the user, followed by presentation of an extending bar or a moving object on a computer screen. In this chapter, we discuss the importance of a visual feedback that resembles human actions, the effect of human factors such as confidence and motivation, and the role of embodiment in the learning process of a motor imagery task. Our results from a series of experiments in which users BCI-operated a humanlike android robot confirm that realistic visual feedback can induce a sense of embodiment, which promotes a significant learning of the motor imagery task in a short amount of time. We review the impact of humanlike visual feedback in optimized modulation of brain activity by the BCI users.",book:{id:"6610",slug:"evolving-bci-therapy-engaging-brain-state-dynamics",title:"Evolving BCI Therapy",fullTitle:"Evolving BCI Therapy - Engaging Brain State Dynamics"},signatures:"Maryam Alimardani, Shuichi Nishio and Hiroshi Ishiguro",authors:[{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro"},{id:"231131",title:"Dr.",name:"Maryam",middleName:null,surname:"Alimardani",slug:"maryam-alimardani",fullName:"Maryam Alimardani"},{id:"231134",title:"Dr.",name:"Shuichi",middleName:null,surname:"Nishio",slug:"shuichi-nishio",fullName:"Shuichi Nishio"}]}],mostDownloadedChaptersLast30Days:[{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:193348,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. Vaccaro",authors:[{id:"91165",title:"Prof.",name:"Vafa",middleName:null,surname:"Rahimi-Movaghar",slug:"vafa-rahimi-movaghar",fullName:"Vafa Rahimi-Movaghar"}]},{id:"63258",title:"Anatomy and Function of the Hypothalamus",slug:"anatomy-and-function-of-the-hypothalamus",totalDownloads:4632,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"The hypothalamus is a small but important area of the brain formed by various nucleus and nervous fibers. Through its neuronal connections, it is involved in many complex functions of the organism such as vegetative system control, homeostasis of the organism, thermoregulation, and also in adjusting the emotional behavior. The hypothalamus is involved in different daily activities like eating or drinking, in the control of the body’s temperature and energy maintenance, and in the process of memorizing. It also modulates the endocrine system through its connections with the pituitary gland. Precise anatomical description along with a correct characterization of the component structures is essential for understanding its functions.",book:{id:"6331",slug:"hypothalamus-in-health-and-diseases",title:"Hypothalamus in Health and Diseases",fullTitle:"Hypothalamus in Health and Diseases"},signatures:"Miana Gabriela Pop, Carmen Crivii and Iulian Opincariu",authors:null},{id:"57103",title:"GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets",slug:"gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets",totalDownloads:3565,totalCrossrefCites:4,totalDimensionsCites:10,abstract:"Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain’s overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Christiane S. Hampe, Hiroshi Mitoma and Mario Manto",authors:[{id:"210220",title:"Prof.",name:"Christiane",middleName:null,surname:"Hampe",slug:"christiane-hampe",fullName:"Christiane Hampe"},{id:"210485",title:"Prof.",name:"Mario",middleName:null,surname:"Manto",slug:"mario-manto",fullName:"Mario Manto"},{id:"210486",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Mitoma",slug:"hiroshi-mitoma",fullName:"Hiroshi Mitoma"}]},{id:"35802",title:"Cross-Cultural/Linguistic Differences in the Prevalence of Developmental Dyslexia and the Hypothesis of Granularity and Transparency",slug:"cross-cultural-linguistic-differences-in-the-prevalence-of-developmental-dyslexia-and-the-hypothesis",totalDownloads:3622,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"673",slug:"dyslexia-a-comprehensive-and-international-approach",title:"Dyslexia",fullTitle:"Dyslexia - A Comprehensive and International Approach"},signatures:"Taeko N. Wydell",authors:[{id:"87489",title:"Prof.",name:"Taeko",middleName:"N.",surname:"Wydell",slug:"taeko-wydell",fullName:"Taeko Wydell"}]},{id:"58597",title:"Testosterone and Erectile Function: A Review of Evidence from Basic Research",slug:"testosterone-and-erectile-function-a-review-of-evidence-from-basic-research",totalDownloads:1370,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Androgens are essential for male physical activity and normal erectile function. Hence, age-related testosterone deficiency, known as late-onset hypogonadism (LOH), is considered a risk factor for erectile dysfunction (ED). This chapter summarizes relevant basic research reports examining the effects of testosterone on erectile function. Testosterone affects several organs and is especially active on the erectile tissue. The mechanism of testosterone deficiency effects on erectile function and the results of testosterone replacement therapy (TRT) have been well studied. Testosterone affects nitric oxide (NO) production and phosphodiesterase type 5 (PDE-5) expression in the corpus cavernosum through molecular pathways, preserves smooth muscle contractility by regulating both contraction and relaxation, and maintains the structure of the corpus cavernosum. Interestingly, testosterone deficiency has relationship to neurological diseases, which leads to ED. Testosterone replacement therapy is widely used to treat patients with testosterone deficiency; however, this treatment might also induce some problems. Basic research suggests that PDE-5 inhibitors, L-citrulline, and/or resveratrol therapy might be effective therapeutic options for testosterone deficiency-induced ED. Future research should confirm these findings through more specific experiments using molecular tools and may shed more light on endocrine-related ED and its possible treatments.",book:{id:"5994",slug:"sex-hormones-in-neurodegenerative-processes-and-diseases",title:"Sex Hormones in Neurodegenerative Processes and Diseases",fullTitle:"Sex Hormones in Neurodegenerative Processes and Diseases"},signatures:"Tomoya Kataoka and Kazunori Kimura",authors:[{id:"219042",title:"Ph.D.",name:"Tomoya",middleName:null,surname:"Kataoka",slug:"tomoya-kataoka",fullName:"Tomoya Kataoka"},{id:"229066",title:"Prof.",name:"Kazunori",middleName:null,surname:"Kimura",slug:"kazunori-kimura",fullName:"Kazunori Kimura"}]}],onlineFirstChaptersFilter:{topicId:"18",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82953",title:"Early Visual Areas are Activated during Object Recognition in Emerging Images",slug:"early-visual-areas-are-activated-during-object-recognition-in-emerging-images",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105756",abstract:"Human observers can reliably segment visual input and recognise objects. However, the underlying processes happen so quickly that they normally cannot be captured with fMRI. We used Emerging Images (EI), which contains a hidden object and extends the process of recognition, to investigate the involvement of early visual areas (V1, V2 and V3) and lateral occipital complex (LOC) in object recognition. The early visual areas were located with a retinotopy scan and the LOC with a localiser. The participants (N=8) then viewed an EI, followed by the hidden object’s silhouette (disambiguation), and then, the EI was repeated. BOLD responses before and after disambiguation were compared. The retinotopy parameters were used to back-project the BOLD response onto the visual field, creating spatially detailed maps of the activity change. V1 and V2 (but not V3) showed stronger response after disambiguation, while there was no difference in the LOC. The back-projections revealed no distinct pattern or changes in activity on object location, indicating that the activity in V1 and V2 is not specific for voxels corresponding to the object location. We found no difference before and after disambiguation in the LOC, which may be repetition suppression counteracting the effect of recognition.",book:{id:"11374",title:"Sensory Nervous System - Computational Neuroimaging Investigations of Topographical Organization in Human Sensory Cortex",coverURL:"https://cdn.intechopen.com/books/images_new/11374.jpg"},signatures:"Marleen Bakker, Hinke N. Halbertsma, Nicolás Gravel, Remco Renken, Frans W. Cornelissen and Barbara Nordhjem"},{id:"82931",title:"Neuroinflammation in Traumatic Brain Injury",slug:"neuroinflammation-in-traumatic-brain-injury",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.105178",abstract:"Neuroinflammation following traumatic brain injury (TBI) is an important cause of secondary brain injury that perpetuates the duration and scope of disease after initial impact. This chapter discusses the pathophysiology of acute and chronic neuroinflammation, providing insight into factors that influence the acute clinical course and later functional outcomes. Secondary injury due to neuroinflammation is described by mechanisms of action such as ischemia, neuroexcitotoxicity, oxidative stress, and glymphatic and lymphatic dysfunction. Neurodegenerative sequelae of inflammation, including chronic traumatic encephalopathy, which are important to understand for clinical practice, are detailed by disease type. Prominent research topics of TBI animal models and biomarkers of traumatic neuroinflammation are outlined to provide insight into the advances in TBI research. We then discuss current clinical treatments in TBI and their implications in preventing inflammation. To complete the chapter, recent research models, novel biomarkers, and future research directions aimed at mitigating TBI will be described and will highlight novel therapeutic targets. Understanding the pathophysiology and contributors of neuroinflammation after TBI will aid in future development of prophylaxis strategies, as well as more tailored management and treatment algorithms. This topic chapter is important to both clinicians and basic and translational scientists, with the goal of improving patient outcomes in this common disease.",book:{id:"11367",title:"Traumatic Brain Injury",coverURL:"https://cdn.intechopen.com/books/images_new/11367.jpg"},signatures:"Grace Y. Kuo, Fawaz Philip Tarzi, Stan Louie and Roy A. Poblete"},{id:"82876",title:"Oxygen Tissue Levels as an Effectively Modifiable Factor in Alzheimer’s Disease Improvement",slug:"oxygen-tissue-levels-as-an-effectively-modifiable-factor-in-alzheimer-s-disease-improvement",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.106331",abstract:"Despite the advance in biochemistry, there are two substantial errors that have remained for at least two centuries. One is that oxygen from the atmosphere passes through the lungs and reaches the bloodstream, which distributes it throughout the body. Another major mistake is the belief that such oxygen is used by the cell to obtain energy, by combining it with glucose. Since the late nineteenth century, it began to be published that the gas exchange in the lungs cannot be explained by diffusion. Even Christian Bohr suggested that it looked like a cellular secretion. But despite experimental evidence to the contrary and based only on theoretical models, the dogma that our body takes the oxygen it contains inside from the air around it has been perpetuated to this day. The oxygen levels contained in the human body are high, close to 99%, and the atmosphere only contains between 19 and 21%. The hypothesis that there is a supposed oxygen concentrating mechanism has not been experimentally proven to date, after almost two centuries. The mistaken belief, even among neurologists, that our body takes oxygen from the atmosphere is widespread, even though there is no experimental basis to support it, just theoretical models. Our finding that the human body can take oxygen from the water it contains, not from the air around it, like plants, comes to mark a before and after in biology in general, and the CNS is no exception. Therefore, establishing the true origin of the oxygen present within our body and brain will allow us to better understand the physio pathogenesis of neurodegenerative diseases.",book:{id:"11637",title:"Neuropsychology of Dementia",coverURL:"https://cdn.intechopen.com/books/images_new/11637.jpg"},signatures:"Arturo Solís Herrera"},{id:"82859",title:"Impact of Hypoxia on Astrocyte Induced Pathogenesis",slug:"impact-of-hypoxia-on-astrocyte-induced-pathogenesis",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.106263",abstract:"Astrocytes are the most abundant cells of the central nervous system. These cells are of diverse types based on their function and structure. Astrocyte activation is linked mainly with microbial infections, but long-term activation can lead to neurological impairment. Astrocytes play a significant role in neuro-inflammation by activating pro-inflammatory pathways. Activation of interleukins and cytokines causes neuroinflammation resulting in many neurodegenerative disorders such as stroke, growth of tumours, and Alzheimer’s. Inflammation of the brain hinders neural circulation and compromises blood flow by affecting the blood–brain barrier. So the oxygen concentration is lowered, causing brain hypoxia. Hypoxia leads to the activation of nuclear factor kappa B (NFkB) and hypoxia-inducible factors (HIF), which aggravates the inflammatory state of the brain. Hypoxia evoked changes in the blood–brain barrier, further complicating astrocyte-induced pathogenesis.",book:{id:"10744",title:"Astrocytes in Brain Communication and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10744.jpg"},signatures:"Farwa Munir, Nida Islam, Muhammad Hassan Nasir, Zainab Anis, Shahar Bano, Shahzaib Naeem, Atif Amin Baig and Zaineb Sohail"},{id:"82839",title:"Neurophysiology of Emotions",slug:"neurophysiology-of-emotions",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.106043",abstract:"Emotions are automatic and primary patterns of purposeful cognitive-behavioral organizations. They have three main functions: coordination, signaling, and information. First, emotions coordinate organs and tissues, thus predisposing the body to peculiar responses. Scholars have not reached a consensus on the plausibility of emotion-specific response patterns yet. Despite the limitations, data support the hypothesis of specific response patterns for distinct subtypes of emotions. Second, emotional episodes signal the current state of the individual. Humans display their state with verbal behaviors, nonverbal actions (e.g., facial movements), and neurovegetative signals. Third, emotions inform the brain for interpretative and evaluative purposes. Emotional experiences include mental representations of arousal, relations, and situations. Every emotional episode begins with exposure to stimuli with distinctive features (i.e., elicitor). These inputs can arise from learning, expressions, empathy, and be inherited, or rely on limited aspects of the environment (i.e., sign stimuli). The existence of the latter ones in humans is unclear; however, emotions influence several processes, such as perception, attention, learning, memory, decision-making, attitudes, and mental schemes. Overall, the literature suggests the nonlinearity of the emotional process. Each section outlines the neurophysiological basis of elements of emotion.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Maurizio Oggiano"},{id:"82172",title:"Neuroimaging in Common Neurological Diseases Treated by Anticoagulants",slug:"neuroimaging-in-common-neurological-diseases-treated-by-anticoagulants",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.105128",abstract:"Stroke imaging/Cerebral Venous sinus thrombosis/Arterial dissecting disease in Head and Neck regions/Neurocomplication of anticoagulation therapy. Nowsday, anticoagulant drugs are common drugs used in daily practice for patients in neurology clinic. Anticoagulant treatment used for treated symptomatic patients as well as for prophylaxis therapy in asymptomatic patients. The purpose of this chapter based on the review of essential neuroimaging in the most common neurological conditions that benefit from treatment with anticoagulant drugs such as ischemic stroke, cerebral venous sinus thrombosis, and arterial dissecting disease of head and neck arteries and will be enclosed with neuroimaging in case of neurocomplication by anticoagulant therapy.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Pipat Chiewvit"}],onlineFirstChaptersTotal:12},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713",scope:"
\r\n\tScientists have long researched to understand the environment and man’s place in it. The search for this knowledge grows in importance as rapid increases in population and economic development intensify humans’ stresses on ecosystems. Fortunately, rapid increases in multiple scientific areas are advancing our understanding of environmental sciences. Breakthroughs in computing, molecular biology, ecology, and sustainability science are enhancing our ability to utilize environmental sciences to address real-world problems. \r\n\tThe four topics of this book series - Pollution; Environmental Resilience and Management; Ecosystems and Biodiversity; and Water Science - will address important areas of advancement in the environmental sciences. They will represent an excellent initial grouping of published works on these critical topics.
",coverUrl:"https://cdn.intechopen.com/series/covers/25.jpg",latestPublicationDate:"August 8th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"197485",title:"Dr.",name:"J. Kevin",middleName:null,surname:"Summers",slug:"j.-kevin-summers",fullName:"J. Kevin Summers",profilePictureURL:"https://mts.intechopen.com/storage/users/197485/images/system/197485.jpg",biography:"J. Kevin Summers is a Senior Research Ecologist at the Environmental Protection Agency’s (EPA) Gulf Ecosystem Measurement and Modeling Division. He is currently working with colleagues in the Sustainable and Healthy Communities Program to develop an index of community resilience to natural hazards, an index of human well-being that can be linked to changes in the ecosystem, social and economic services, and a community sustainability tool for communities with populations under 40,000. He leads research efforts for indicator and indices development. Dr. Summers is a systems ecologist and began his career at the EPA in 1989 and has worked in various programs and capacities. This includes leading the National Coastal Assessment in collaboration with the Office of Water which culminated in the award-winning National Coastal Condition Report series (four volumes between 2001 and 2012), and which integrates water quality, sediment quality, habitat, and biological data to assess the ecosystem condition of the United States estuaries. He was acting National Program Director for Ecology for the EPA between 2004 and 2006. He has authored approximately 150 peer-reviewed journal articles, book chapters, and reports and has received many awards for technical accomplishments from the EPA and from outside of the agency. Dr. Summers holds a BA in Zoology and Psychology, an MA in Ecology, and Ph.D. in Systems Ecology/Biology.",institutionString:null,institution:{name:"Environmental Protection Agency",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"38",title:"Pollution",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",isOpenForSubmission:!0,editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",biography:"Ismail Md. Mofizur Rahman (Ismail M. M. Rahman) assumed his current responsibilities as an Associate Professor at the Institute of Environmental Radioactivity, Fukushima University, Japan, in Oct 2015. He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"312999",title:"Dr.",name:"Bernard O.",middleName:null,surname:"Asimeng",slug:"bernard-o.-asimeng",fullName:"Bernard O. Asimeng",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}}]}},subseries:{item:{id:"17",type:"subseries",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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