Magnetic properties of the valve components
\r\n\tThis book will describe the self-assembly of materials and supramolecular chemistry design principles for a broad spectrum of materials, including bio-inspired amphiphiles, metal oxides, metal nanoparticles, and organic-inorganic hybrid materials. It will provide fundamental concepts of self-assembly design approaches and supramolecular chemistry principles for research ideas in nanotechnology applications. The book will focus on three main themes, which include: the self-assembly and supramolecular chemistry of amphiplies by coordination programming, the supramolecular structures and devices of inorganic materials, and the assembly-disassembly of organic-inorganic hybrid materials. The contributing chapters will be written by leading scientists in their field, with the hope that this book will provide a foundation on supramolecular chemistry principles to students and active researchers who are interested in nanoscience and nanoengineering fields.
",isbn:"978-1-83969-702-9",printIsbn:"978-1-83969-701-2",pdfIsbn:"978-1-83969-703-6",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"e9cc643ae0a219e91e445a1e61b33a22",bookSignature:"Prof. Hemali Rathnayake and Dr. Gayani Pathiraja",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11908.jpg",keywords:"Amphiphiles, Artificial Siderophores, Coordination Chemistry, Self-Assembly Design, Supramolecular Structures, Metal Oxides, Metal Particles, 2D Inorganic Materials, Supramolecular Devices, Stimuli-Responsive Materials, Assembly-Disassembly Design, Superstructures",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 27th 2022",dateEndSecondStepPublish:"July 1st 2022",dateEndThirdStepPublish:"August 30th 2022",dateEndFourthStepPublish:"November 18th 2022",dateEndFifthStepPublish:"January 17th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"6 days",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Rathnayake is a pioneering researcher in self-assembly and supramolecular chemistry, with a Ph.D. from the University of Massachusetts Amherst, US. She is an inventor of three innovative technologies, including the Bioinspried Sub-7 nm self-assembled structures for patterning, and holder of multiple registered patents.",coeditorOneBiosketch:"Dr. Gayani Pathiraja is a Postdoctoral Research Scholar at the Joint School of Nanoscience and Nanoengineering (JSNN). She received her Ph.D. in Nanoscience from the University of North Carolina at Greensboro in 2021. Her research interests focus on the crystal growth mechanism and kinetics of metal oxide nanostructure formation via self-assembly.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"323782",title:"Prof.",name:"Hemali",middleName:null,surname:"Rathnayake",slug:"hemali-rathnayake",fullName:"Hemali Rathnayake",profilePictureURL:"https://mts.intechopen.com/storage/users/323782/images/system/323782.jpg",biography:"Dr. Hemali Rathnayake, Associate Professor in the Department of Nanoscience at the Joint School of Nanoscience and Nanoengineering, the University of North Carolina at Greensboro, USA, obtained her B.S. in Chemistry from the University of Peradeniya in Sri Lanka. She obtained her Ph.D. from the University of Massachusetts Amherst (UMass), Department of Chemistry in 2007. She was a Postdoctoral research fellow at Polymer Science & Engineering, UMass Amherst. \r\nDr. Rathnayake is a pioneer scientist and a chemist in the field of Nanomaterials Chemistry, with a focus on the interfacial interaction of nanomaterials, molecules, macromolecules, and polymers in homogeneous and heterogeneous media. Her research on the design, synthesis, self-assembly, and application of well-defined superstructures in nanoelectronics, environmental remediation, and sustainable energy has impacted the scientific community with highly rated peer-reviewed journals publications, and more than 80 invited talks to scientific and non-scientific communities including colleges and high schools.",institutionString:"University of North Carolina at Greensboro",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of North Carolina at Greensboro",institutionURL:null,country:{name:"United States of America"}}}],coeditorOne:{id:"427650",title:"Dr.",name:"Gayani",middleName:null,surname:"Pathiraja",slug:"gayani-pathiraja",fullName:"Gayani Pathiraja",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003CCSN2QAP/Profile_Picture_1644217020559",biography:"Dr. Gayani Pathiraja is a Postdoctoral Research Scholar at the Joint School of Nanoscience and Nanoengineering (JSNN). She received her Ph.D. in Nanoscience from the University of North Carolina at Greensboro (UNCG) in 2021. Her expertise area of focus is investigating the crystal growth mechanism and kinetics of metal oxide nanostructure formation via in-situ self-assembly design principles. \r\nDr. Pathiraja earned her master’s degree in electrochemistry/Environmental Engineering from the University of Peradeniya, Sri Lanka, and her Bachelor’s degree in Materials Science and Technology from Uva Wellassa University, Sri Lanka. Dr. Pathiraja started her academic career as a lecturer at the Department of Engineering Technology, University of Ruhuna, Sri Lanka in 2016. She is a co-author of several peer-reviewed journal publications and a book chapter, and she has presented her work at several regional, international, and national conferences.",institutionString:"University of North Carolina at Greensboro",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of North Carolina at Greensboro",institutionURL:null,country:{name:"United States of America"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"8",title:"Chemistry",slug:"chemistry"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"466998",firstName:"Dragan",lastName:"Miljak",middleName:"Anton",title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/466998/images/21564_n.jpg",email:"dragan@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"39986",title:"Optimal Design Methodology of Magnetorheological Fluid Based Mechanisms",doi:"10.5772/51078",slug:"optimal-design-methodology-of-magnetorheological-fluid-based-mechanisms",body:'Magnetorheological fluid (MRF) is a non-colloidal suspension of magnetizable particles that are on the order of tens of microns (20-50 microns) in diameter. Generally, MRF is composed of oil, usually mineral or silicone based, and varying percentages of ferrous particles that have been coated with an anti-coagulant material. When inactivated, MRF displays Newtonian-like behavior. When exposed to a magnetic field, the ferrous particles that are dispersed throughout the fluid form magnetic dipoles. These magnetic dipoles align themselves along lines of magnetic flux. The fluid was developed by Jacob Rabinow at the US National Bureau of Standards in the late 1940\'s. For the first few years, there was a flurry of interest in MRF but this interest quickly waned. In the early 1990\'s there was resurgence in MRF research that was primarily due to Lord Corporation\'s research and development. Although similar in operation to electro-rheological fluids (ERF) and Ferro-fluids, MR devices are capable of much higher yield strengths when activated. For this advantage, many MRF-based mechanisms have been developed such as MR dampers, MR brake, MR clutch, MR valve... and some of them are now commercial. As well-known that performance of MRF based systems significantly depends on the activating magnetic circuit, therefore, by optimal design of the activating magnetic circuit, the performance of MRF-based systems can be optimized. Recently, there have been various researches on optimal design of MRF-based devices such as MR damper, MR valve, MR brake. The results from these studies showed that performance of MRF-based systems can be significantly improved via optimal design of the magnetic circuit of the systems.
Consequently, this chapter focuses on the methodology of optimal design of MRF-based devices. The chapter is organized as follows; in section 2, fundamentals and the theory behind MRF are overviewed. Section 3 deals with the modes used in MRF based devices and several different devices featuring MRF are discussed. In the fourth section, optimal design methodology of MRF-based mechanisms is considered. In this section, firstly the necessity of optimal design and the state of the art are discussed. Then the magnetic circuit analysis and the modeling of MRF devices are considered. In addition, the optimization problem of MRF devices is figured out and the methods to solve the problem are investigated. Section 5 is devoted to deal with a case study of MR valve optimal design. In this case study, several valve configurations such as single-coil, multiple-coil and annular-radial MR valves are considered. The chapter is then closed by the conclusion
Generally, MRF consists of non-colloidal suspensions, magnetically soft ferromagnetic, ferrimagnetic or paramagnetic elements and compounds in a non-magnetic medium. In practice, MRF usually consists of suitable magnetizable particles such as iron, iron alloys, iron oxides, iron nitride, iron carbide, carbonyl iron, nickel and cobalt [1, 2]. Among these, a preferred magnetic responsive particle that is commonly used to prepare MRF is carbonyl iron. The possible maximum yield stress induced by MR effect is mainly determined by the lowest coercivity and the highest magnitude of saturation magnetization of the dispersed particles. Therefore, soft magnetic material with high purity such as carbonyl iron powder appears to be the main magnetic phase for most of the practicalMRF composition [3]. Other than carbonyl iron, Fe-Co alloys and Fe-Ni alloyscan also be used as MR materials, whereby, Fe contributes to the high saturation magnetization. In contrary, some of the ferrimagnetic materials such as Mn-Zn ferrite, Ni-Zn ferrite and ceramic ferrites have low saturation magnetizations and are therefore suitable to be applied in low yield stress applications [1].MR particles are typically in the range of 0.1 to 10μm [4, 5], which are about 1000 times bigger than those particles in the ferrofluids [6]. In the MRF, magnetic particles within a certain size distribution can give a maximum volume fraction without causing unacceptable increasing in zero-field viscosity. For instance, fluid composition that consists of 50% volume of carbonyl iron powder was used in the application of electromechanically controllable torque-applying device.
The carrier liquid forms the continuous phase of the MRF. Examples of appropriate fluids include silicone oils, mineral oils, paraffin oils, silicone copolymers, white oils, hydraulic oils, transformer oils, halogenated organic liquids, diesters, polyoxyalkylenes, fluorinated silicones, glycols, water and synthetic hydrocarbon oils [7, 2]. A combination of these fluids may also be used as the carrier component of the MRF. In the earlier patents,inventors were using magnetizable particles dispersed in a light weight hydrocarbon oil [8], either a liquid, coolant, antioxidant gas or a semi-solid grease [9] and either a silicone oil or a chlorinated or fluorinated suspension fluid[10]. However, when the particles settled down, the field-induced particle chains formed incompletely at best in which MR response was critically degraded. Later, in order to prevent further sedimentation, new compositions of MRF with consideration on viscoplastic [11] and viscoelastic continuous phases [12] were formulated, so that the stability could be improved immensely. In addition, a composite MRF has been prepared by Pan et al. [13] with a combination of iron particles powder, gelatine and carrier fluids. They showed that the MR effects were superior under low magnetic field strength, and had a better stability compared to pure iron carbonyl powder alone.
Surfactants, nanoparticles, nanomagnetizable or coating magnetizable particles can be added to reduce the sedimentation of the heavy particles in the liquid phase [14, 13]. The sedimentation phenomenon can cause a shear-thinning behaviour of the suspension [15]. With further sedimentation, with MRF under the influence of high stress and high shear rate over a long period of time, the fluid will thicken (in-use-thickening) [16, 17]. Sedimentation phenomenon will reduce the MR effect where the particles in the MRF are settled down and form a hard “cake” that consists of firmly bound primary particles due to incomplete chain formation [18]. Anti-settling agent such as organoclay can provide soft sedimentation. When the composition of MRF has relatively low viscosity, it does not settle hard and can easily re-disperse [2]. Coating of the polymer layer also influences magnetic properties of the particles and cause them to easily re-disperse after the magnetic field is removed [19]. However, specific properties of MRF such as shear and yieldstresses under the same conditions were enormously degraded inevitably by addition of the coating layer. This is due to the shielding of the polymer layer that affects the magnetic properties of the particles [19, 20]. In addition, some additives can improve the secondary properties like oxidation stability or abrasion resistance.
The static magnetic properties of MRF are important to design any MRF-based devices and generally can be characterized by B-H and M-H hysteresis. Through the magnetic properties, the dependence of the MRF response on the applied current in the device can be predicted. Under the influence of the magnetic field, a standard model for the structure is used to predict the behaviour of the particle of MRF [21]. The model is based on a cubic network of infinite chains of the particles arranged in a line with respect to the direction of the magnetic field as shown in Figure 1.
Schematic presentation of the affine deformation of a chain of spherical particles
The chains are considered to deform with the same distance between any pair of neighbours in the chains and increase at the same rate with the strain when the MRF is strained. This model is quite simple since the chains, in actual case, are formed into some more compact aggregates of spheres in which can be constituted in the form of cylinders. Under shear stress, these aggregates might deform and eventually break. Even though the particles develop into different complicated structures under different conditions [22], the standard model still can be used in order to give a valid prediction of the yield stress [21]. The equation of motion of each particle under a magnetic field is required in order to evaluate the bulk property of MRF. At a very low magnetic field, the magnetic force tensor
where
where
where
At high magnetic fields, the magnitude of the moment can be considered as independent point dipoles as magnetization of particles reaches saturation. In this case, the magnetic moment is given by [25].
where
Rheology is the response of materials to an applied stress [26]. Rheology is an interdisciplinary field and is used to describe the properties of a wide variety of materials such as oil, food, ink, polymers, clay, concrete, asphalt and others. Rheology measurements and parameters can be used to determine the processing behaviour of non-Newtonian materials, viscoelastic behaviour as a function of time, the degree of stability of a formulation at rest condition or during transport, and zero shear viscosity or the maximum viscosity of the fluid phase to prevent sedimentation [27]. The viscosity equation on the basis of a hydrodynamic theory for dilute dispersions of spherical particles has been developed by Einstein about 100 years ago [28]. The equation has been derived as
where
However, these equations do not depend on the particle size but instead depend on the particle shape and solid concentration. Thus, Toda and Furuse [30] extended the equation in order to satisfy the viscosity behaviour of concentrated dispersion for small and large particles, respectively given by,
where
where
Classification of time-independent non-Newtonian fluid
MRF responds to the external field, where the particles are held together to form chains parallel to the applied field. The interaction between the particles impedes to a certain level of the shear stress without breaking and simultaneously increases the viscosity of the fluids [32]. In many cases,the effect of MRF is described by Bingham Plastic model [33]. A modified or extended Bingham model, or a combination of Bingham model with other models such as viscous and coulomb friction have also been used to describe the behaviour of MRF [34]. In the absence of an external field, MRF behave like a normal fluid which is known as Newtonian fluid. There are many factors that influence the rheological properties of controllable MRF such as concentration and density of particles, particle size and shape distribution, properties of the carrier fluid [35], additional additives, applied field and temperature. The relationships of all these factors are very complex and are important in establishing methodology to improve efficiency of these fluids for suitable applications. Excellent MRF must have low viscosity and coercivityof particles without the influence of an external magnetic field and can achieve maximum yield stress in the presence of the external magnetic field. Gross [8] in his invention related to the valve for magnetic fluids, found that the advantage of large particle sizes or heavy suspensions can increase the size of the gap which also increases the flow of the fluid.Conversely, the large particles of the magnetically active phase of MRF lead to a strong tendency for particles to settle out of the liquid phase [19].
Some of the techniques are typically necessary in order to increase the yield stress; either by increasing the volume fraction of MR particles or by increasing the strength of the applied magnetic field. However, neither of these techniques is desirable since a higher volume fraction of the MR particles can add significant weight to the MR devices as well as increases the overall off-state viscosity of the material. In that connection, restricting the size and geometry of the MR device capable of utilizing that material, and a higher magnetic field significantly increases the power requirement of the device. To overcome this difficulty, Carlson [36] in his patent introduced alloy-particles material that was used as a solid particle instead of the common carbonyl iron. This MRF independently increases the yield stress without requiring increment of either the volume fraction of particles or magnetic field strength.
MRF models play an important role in the development of MRF based devices.Moreover, accurate models that can predict the performance of these MRF devices are an important part of implementation of such devices. MRF demonstrates nonlinear behavior when subjected to external magnetic fields. The rheological behavior of these materials can be separated into distinct preyield and post-yield regimes. A wide variety of nonlinear models have been used to characterize MRF, including the Bingham plastic model [37, 38], the biviscous model [39], the Herschel–Bulkley model [40, 41], and Eyring plastic model [42]. Although there have been several models have been developed and applied for MRF the two most popular models have been widely used with reasonable accuracy and computational cost are the Bingham plastic model and the Herschel–Bulkley plastic model. Therefore, in this chapter these two constitutive models are used.
Bingham plastic model
The so-called Bingham plastic model includes a variable rigid perfectly plastic element connected in parallel to a Newtonian viscosity element. This model assumes that the fluid exhibits shear stress proportional to shear rate in the post-yield region and can be expressed as [37, 38]
where
Herschel-Bulkley plastic model
In cases where the fluid experiences post-yield shear thickening or shear thinning, especially when the MRF experiences high shear rate, this choice of constitutive equation can result in an overestimation. In this case, the Herschel-Bulkley plastic model is more suitable [43]. The Herschel-Bulkley model can be expressed by
where
It is noteworthy that, in the above, the post-yield parameters of the MRF such as the post-yield viscosity, the consistency parameter and the fluid behavior index are assumed to be independent onthe applied magnetic field. In practice, these parameters are slightly affected by the applied magnetic field. Zubieta et al. [44] have proposed field-dependent plastic models for MRF based on the original Bingham plastic and Herschel-Bulkley plastic models. The models were then applied in several researches [45, 46] with experimental agreement. In the field dependent Bingham and Herschel-Bulkley model, the rheological properties of MRF depend applied magnetic field and can be estimated by the following equation
Viscoplastic models often used to describe MR fluids
where
Figure 4a schematically show the valve mode which have been used in many MR devices where the flow of the MRF between motionless plates or a duct is created by a pressure drop. The magnetic field, which is applied perpendicular to the direction of the flow, is used to change the rheological properties of the MRF in order to control the flow. Therefore, the increase in yield stress or viscosity alters the velocity profile of the fluid in the gap between two plates. A typical velocity profile for Bingham-plastic of the valve mode is illustrated in Figure 4b.The velocity profile contains a pre-yield region, where the velocity gradient is zero across the plug region. The velocity profile of MRF between two parallel plates can be represented by the following relation [47]
Here,
Valve mode in the MR application
The second working mode for controllable fluid devices is the direct shear mode. An MRF is situated between two surfaces, whereby one surface slides or rotates in relation to the other, with a magnetic field applied perpendicularly to the direction of motion of these shear surfaces. Figure 5 shows the concept of shear mode in MRF application
The concept of shear mode
The direct shear mode has been studied thoroughly especially in the MR damper technology. Masri et al. [52] proposed a curve fitting technique for representing the nonlinear restoring force of an ER device in order to characterize the ER material behaviour under static and dynamic loading over a wide range of electric fields. Spencer et al. [53] developed a phenomenological model which is based on the improved Bouc-Wen hysteresis model to represent MR dampers. Moreover, Wereley et al. have proposed a non-dimensional approach to model different types of shear damper (linear shear mode, rotary drum and rotary disc damper) [54]. In the research, the Bingham–plastic, biviscous, and Herschel–Bulkley models are considered. In terms of the behaviour of the damper under conditions of high-velocity and high field input, Lee et al. [55] recommended the Herschel-Bulkley shear model to analyze the performance of impact damper systems.Furthermore, Neelakantan et al. [56] incorporated a volume fraction profile of particles with an analytical technique for calculating the torque transmitted in clutches experiencing particle centrifuging. The effect of centrifuging at high rotational speeds and the subsequent sealing problems associated with it can be mitigated by the proposed model. Extraordinary features of the direct shear mode like simplicity, fast response, simple interface between electrical power input and mechanical power output using magnetic fields, and controllability are features that make MRF technology suitable for many applications such as dampers, brakes, clutches and polishing devices [56-59].
The third working mode of MRF is the squeeze mode shown in Figure 6. This mode has not been widely investigated. Squeeze mode operates when a force is applied to the plates in the same direction of a magnetic field to reduce or expand the distance between the parallel plates causing a squeeze flow. In squeeze mode, the MRF is subjected to dynamic (alternate between tension and compression) or static (individual tension or compression) loadings. As the magnetic field charges the particles, the particle chains formed between the walls become rigid with rapid changes in viscosity. The displacements engaged in squeeze mode are relatively very small (few millimeters) but require large forces. The squeeze mode was disclosed by Stanway et al. [60] in 1992. They studied the usage of ER fluids in squeeze mode and found that the yield stress produced under DC excitation could be several times greater than the shear mode. The same outcome was later confirmed by Monkman [61] for fluids under compressive stress. Consequently, systematic investigations have been carried out by many researchers to evaluate the mechanical and electrical properties of ER and MRF in squeeze flow. Despite the fact that the Bingham plastic model was used to describe the behaviour of ER fluid in shear mode, Nilsson and Ohlson [62] have not recommended to utilize that model in squeeze mode. Bingham parameters tested from shear mode are not well-founded for the calculation of the squeeze mode behaviour. Sproston et al. [63] characterized the performance of ER fluids in dynamic squeeze mode using a bi-viscous model under a constant potential difference or by a constant field. Later on, Sproston and El Wahed [64] utilized the model to assess the fluid’s response to a step-change in the applied field and the influence of the size of solid phase. Even though the model was useful to predict the peak values of the input and transmitted forces [65], a more refined model is needed, according to authors, to predict the detailed temporal variations. Therefore, a new approach of modified bi-viscous model was developed by El Wahed et al. in order to model the behaviour of an ER squeeze mode cell under dynamic conditions [66, 67]. Furthermore, Yang and Zhu [68] extended this latter model by incorporating Navier slip condition to obtain the radial velocity, pressure gradient, pressure and squeeze force.
The concept of squeeze mode
The stress produced by the squeeze mode is the highest stress among other modes and can be used in damping vibrations with low amplitudes and high dynamic forces [69, 70]. In vibration isolation of structural system, the unwanted vibration in a relatively high frequency range can be attenuated by activating the MR mount. Examples for vibration control are isolation engine mount [71], turbo-machinery [72] and squeeze film damper [73]. Another interesting application on the squeeze mode is related to haptic devices where the user can feel the resistance forces by touching and moving a tool [74].
Some of the applications of field responsive fluids take advantage of the combination of two modes for a greater strength and functionality. For instance, dampers can be constructed in three different modes [75]. In a general manner, shear mode exhibits Couette flow through the annular bypass, while a valve flow is characterized by Poiseiulle flow through the annular bypass. The combination of them often gives higher yield stress as compared to stress produced by individual operation modes. Kamath et al. [76] have shown in their analysis and testing of Bingham plastic behaviour that mixed (valve and shear) mode dashpot dampers have higher passive damping than flow mode dampers. The mixed mode damper has a secondary effect of viscous drag as a result of the motion of piston head, instead of relying on the pressure gradient developed by the piston head to push the fluid through the gap created by the fixed electrodes. Wereley and Pang [75] have developed nonlinear quasi-steady ER and MR damper models using idealized Bingham plastic shear flow mechanism to characterize the equivalent viscous damping constant of the dampers. Plug thickness is the strongest variable that contributed to the damper behaviour for both flow and mixed modes.
In another experimental study done by Kulkarni et al. [62], the performance ofhe combination of squeeze and shear modes of MRF in dynamic loading was investigated. Even though squeeze mode can produce the highest strength among all modes, the addition of squeeze mode to shear mode did not always give a better strength than the shear mode alone. However, Tang et al. [77] demonstrated that the yield shear tress can be significantly improved by compressing the MRF along the magnetic field direction before the shear process is performed.
It is well-known that modeling of the MRF based systems is a coupled analysis problem: electromagnetic analysis and fluid system analysis. The purpose of the modeling of an MRF based device is to find the relation between the applied electric power (usually the current applied to the coils) and the output mechanical power such as pressure drops for MR valves, damping force for MR damper, braking torque for MR brakes and transmitted torque for MR clutches. In order to deal with modeling of MRF based devices, firstly the magnetic circuit of the MRF based devices should be solved. In general, the magnetic circuit can be analyzed using the magnetic Kirchoff’s law as follows:
where
where Φ is the magnetic flux of the circuit,
where
By assuming magnetic property of the structural materials of the MR devices is similar (
where
The inductive time constant (
where
In the above,
In some applications, an electromagnet is used in combination with a permanent magnet to control the rheological properties of the MRF as shown in Figure 7. In this case, the permanent magnet is used to shift the off-state (no current in the coil) viscosity of the MRF to a selected value and the electromagnet is used to control the viscosity variations around this value. A frequent situation is that where the magnetic circuit is designed in such a way that the MRF viscosity is maximum when no current flows through the coil. This is particularly useful when the device based on such magnetic circuit has to be blocked the major part of its operation time (such as in release mechanisms, for instance). The magnetic intensity across the active volume of the MRF is determined by [78]
Magnetic coil with MRF filled gap and permanent magnet:a) magnetic circuitb) electric equivalence
where
Magnetic coil with MRF filled gap and permanent magnet with secondary path: a) magnetic circuitb) electric equivalence
The electromagnet will thus not be used to completely cancel the flux produced by the permanent magnet but will only redirect it to the secondary path. This secondary path comprises a higher reluctance air gap in order to concentrate the major part of the flux generated by the permanent magnet in the primary path (comprising the MRF gap) when no current is flowing through the coil. In this case, the magnetic intensity across the active volume of the MRF is determined by [78]
It is interesting to note that, if
This value may seem smaller than what was obtained in the previous case; however, to obtain the same magnetic field inside the MRF gap, the magnet has to be more powerful since it has to compensate for the loss of magnetic flux in the secondary circuit.
In the above, magnetic circuit of the MRF based devices is solved based on the approximation of the analytical analysis. This approach can only used in case of simple geometry. In case of complex geometry or several coils are used, the approach becomes very complicated. Therefore, practically, the magnetic circuit of the MRF based devices is solved by finite element method (FEM). Once the magnetic solution is obtained, the magnetic intensity and magnetic flux density across the active MRF volume can be calculated. The rheological properties of MRF in the active volume are then determined based on the behaviour characteristics of the employed MRF. The behavior characteristics of MRF are usually obtained from experimental results with a curve-fitting algorithm. The most important parameter of MRF is the field-dependent yield stress. There have been several approximate functions have been used to express the dependence of the induced yield stress of MRF on the applied magnetic field. The two most widely used functions are the exponential function and the polynomial function. The former can well expressed the saturation of MRF yield stress as a function of the applied magnetic intensity. However, it exhibits large error at the small value of the applied magnetic intensity. In general, the approximate exponential function of induced yield stress is expressed as following
where
The latter, the approximate polynomial function, can well predict the MRF yield stress at small value of the applied magnetic intensity. The higher order of the polynomial is the more accurate value of the yield stress can be predicted. In practice, the third order polynomial is often used. However, the polynomial function can not express the saturation of the induced yield stress. Therefore, a saturation condition should be added. The 3rd order approximate polynomial function of MRF yield stress can be expressed by
where
In many researches, other characteristics of MRF such as the post yield viscosity (
As aforementioned modeling of MRF based systems is a coupled analysis problem. Therefore, output mechanical power of these systems depends not only on their mechanics behaviors but also on their magnetic circuits. It is obvious that in order to improve performance of the MRF based systems, the optimal design should be taken into account. Generally, the objective of the optimal design is to find significant geometric dimensions of the MRF based devices that maximize an objective function considering typical characteristics such as pressure drop, damping force, dynamic range, braking torque, transmitted force, mass, time response constant and power consumption. Some constraints such as available space, allowable operating temperature, uncontrollable torque etc. may be also considered in the optimal design. There have been several researches focusing on optimal design of MRF devices. Rosenfield and Wereley [48] proposed analytical optimization design method for MR valves and dampers based on the assumption of constant magnetic flux density throughout the magnetic circuit to ensure that one region of the magnetic circuit does not saturate prematurely and cause a bottleneck problem. Nguyen et al. [79] proposed a FEM based optimal design of MR valves (single-coil, two-coil, three-coil and radial-annular types) constrained in a specified volume. This work considered the effects of all geometric variables of MR valves by minimizing the valve ratio calculated from the FE analysis. Later on Nguyen el al. [80] have developed an optimization procedure based on the finite element method in order to find the optimal geometry of MR valves constrained to a specific volume, satisfying a required pressure drop with minimal power consumption. The time response of the valves was also taken into account by considering the inductive time constant as a state variable. The optimization results showed the significance of the optimal design of the MR valves in order to minimize the power consumption. It was also shown that the wire diameter does not significantly affect the optimization solution and can be neglected. The optimal design of MR damper was also performed by Nguyen et al [81], in which the objective function was proposed by a linear combination of the ratios of the damping force, dynamic range and the inductive time constant and their reference values using corresponding weighting factors. Recently, there have been several researches on the optimal design of MR brakes and clutches. Park et al. [82] have performed multidisciplinary design optimization of an automotive MR brake, in which a multi-objective function considering both braking torque and mass of the brake was considered. Nguyen et al. [45] have performed a thorough research on optimal design of MR brake for middle-sized vehicle considering the available space, mass, braking torque and steady heat generated by a zero-field friction torque of the MR brake on cruising at a speed of 100
As abovementioned, the magnetic circuit of the MRF based devices can be solved by an approximation of analytical solution or by FEM. Therefore, the optimal design of these devices can be performed based on either the analytical analysis or finite element analysis (FEA). The former is used only for simple devices such as single coil MR damper [84].In this section, the optimal design of MRF devices based on FEA is introduced. First of all, an objective function should be proposed depending on the purpose of the optimal design and the application of the devices. It is noted that in the optimization problem the objective function is always minimized. Therefore, if the purpose of the optimization is to maximize a performance function of the devices, that function should be transform to an equivalent objective function.The equivalent objective function is the function that when it is minimized, the corresponding performance function is maximized. After the objective function is constructed, the design parameters of the optimization problem should be identified. In addition, the constraints of the optimization problem should be determined if there any. In the next step, an algorithm to obtain the optimal solution should be chosen. It is well-known that there have been numerous methods to find the optimal solution of an optimization problem. They may be non-derivative, first-derivative or second-derivative methods. The non-derivative methods that do not require any derivative of the function are not usually applied to MRF based systems. Although they are generally easy to implement, their convergence properties are rather poor. They may work well in special cases when the function is quite random in character or the variables are essentially uncorrelated. Some typical non-derivative algorithms are the Simplex, Genetic Algorithms and Neural Networks. The second-derivative optimization methods are characterized by fast convergence and affine invariance. However, they require second derivatives and the solution of linear equation can be too expensive for large scale applications. The most popular optimization method, which is widely used in optimal design of MRF based devices, is the first order (derivative) method. Although the convergence rate of the first derivative method is somewhat slower than that of the second-derivative one, the first derivative method is still preferred in many applications because of its inexpensive cost for computation and programming. A typical first derivative optimization algorithm is the conjugate gradient method. The flow chart in Figure 9 shows how to find the optimal solution of MRF based devices based on ANSYS finite element software using the first order method. The procedures from the flow chart can be easily extended to other finite element software.
First of all, initial value of the design variables (DV) should be decided. Computation time of the optimization process significantly depends on the initial value of the DVs. Therefore, the initial value of design variables should be calculated based on a draft calculation or based on practical experience.Then, an analysis file for solving the magnetic circuit and calculating performance characteristics of the devices such as control energy, the inductive time constant, pressure drops, damping force, braking torque and transmitted torque is built. In ANSYS, the analysis file is built using parametric design language (APDL). It is noted that this analysis file can be created from a graphic user interface (GUI) model of ANSYS by using the
where
Flow chart for optimal design of MRF based devices using FEM.
After the analysis file is prepared, the procedures to achieve optimal design parameters of the MRF devices using the first order method of ANSYS optimization tool are performed as shown in Figure 9. Starting with initial value of DVs, by executing the analysis file, the initial value of the performance characteristics of the devices such as control energy, the inductive time constant, pressure drops, damping force, braking torque and transmitted torque are obtained. The ANSYS optimization tool then transforms the constrained optimization problem to an unconstrained one via penalty functions. The dimensionless, unconstrained objective function is formulated as follows:
where
The values of DVs in next iteration (
where the line search parameter
Thus, each iteration is composed of a number of sub-iterations that include search direction and gradient computations.
It is noted that ANSYS software supports optimal design problems by integrating an optimization tool. Therefore, in most cases the optimal solution of the MRF based devices can be solved directly by the ANSYS software without interfacing with any programming software. In order to use the ANSYS optimization tool, it is necessary to set up optimization parameters. To do this, firstly the analysis file should be manually executed once to load all parameters in the analysis file into software buffer memory. After that, from the
Figure 10 shows the structural configurations of the two typical types of MR valves: the annular MR relief valve (Figure 10a) and MR valve with both annular and radial flow paths (Figure 10b). The valve in Figure 10a consists of valve coil, cores and covers. The MRF flows through annular ducts between core A and core B. When the power of the coil is turned on, a magnetic field is exerted on the MRF, which causes the MRF flowing through the ducts to change its state into semi-liquid or solid and stop the flow. Only when the supply pressure gets high enough to offset the yield stress, the fluid can flow through the valve again. The valve in Figure 10b consists of the valve core, magnetic disk and valve housing form a magnetic circuit of the valve. A non-magnetic washer is used to warrant the required thickness of the radial duct. When the magnetic disk is placed coaxially with the valve housing using the cone-shape cap, the annular and radial ducts are formed between the disk and the valve housing, and the disk and the valve core, respectively. MRF flows from the inlet through the first annular and radial duct, then flow along the hole at the center of the core and after that follows the second radial and annular duct to the outlet.
Schematic diagrams of MR valves.
Figure 11a shows a simplified structure and significant dimensions of a single-coil annular MR valve. The valve geometry is featured by the overall effective length
Simplified MR valve configurations
By using Bingham plastic model, the pressure drop of the valve is calculated by [80, 81]
where
The multi-coil MR valve, which was first employed by Spencer et al. to make a high damping force MR damper used in seismic protection system [85], is now widely used in many applications. For MR valve with two coils, the pressure drop is calculated by
where
Similarly, for the three-coil annular MR valve, the pressure drop is calculated by
For the MR valve with both annular and radial flow paths shown in Figure 11b, the pressure drop can be calculated by
where
In the above,
The optimal objective is to minimize the valve ratio defined by the ratio of the viscous pressure drop to the field-dependent pressure drop of the MR valve. This ratio has great effect on the characteristics of the MR valve. It is desirable that the valve ratio takes a small value. The valves are constrained in a cylinder of the radius
In Eq. (42), the unit of the yield stress is
It is noted that, a small change in the valve gap
The ANSYS APDL program is the analysis ANSYS APDL code used in optimal design of the annular single MR valve. The analysis ANSYS APDL code for other types of MR valve can be prepared in the same maner.
Valve Components | Material | Relative Permeability | Saturation Flux Density |
Valve Core | Silicon Steel | B-H curve (Fig. 12a) | 1.5 Tesla |
Valve Housing | Silicon Steel | B-H curve (Fig. 12a) | 1.5 Tesla |
Coil | Copper | 1 | x |
MR Fluid | MRF132-DG | B-H curve (Fig. 12b) | 1.6 Tesla |
Nonmagnetic Cap/Bobbin | Nonmagnetic Steel | 1 | x |
Magnetic properties of the valve components
Magnetic properties of silicon steel and MR fluid
/COM, Magnetic-Nodal /COM, Magnetic-Edge /PREP7 !Element definition ET,1,PLANE13 KEYOPT,1,1,0 KEYOPT,1,2,0 KEYOPT,1,3,1 KEYOPT,1,4,0 KEYOPT,1,5,0 !Material definition MAT,1, ! Silicon Steel (B-H curve) TBDEL,ALL,_MATL MPDEL,ALL,_MATL TB,BH ,_MATL , 1, 9 TBPT,, 130.000000 , 0.380000000 TBPT,, 260.000000 , 0.750000000 TBPT,, 400.000000 , 1.05000000 TBPT,, 430.000000 , 1.10000000 TBPT,, 1000.00000 , 1.30000000 TBPT,, 2000.00000 , 1.40000000 TBPT,, 4000.00000 , 1.46500000 TBPT,, 6000.00000 , 1.49000000 TBPT,, 11000.0000 , 1.51000000 !* MAT,3, ! MR Fluid (B-H curve) TBDEL,ALL,_MATL MPDEL,ALL,_MATL TB,BH ,_MATL , 1, 8 TBPT,, 50000.0000 , 0.300000000 TBPT,, 100000.000 , 0.600000000 TBPT,, 150000.000 , 0.900000000 TBPT,, 290000.000 , 1.30000000 TBPT,, 600000.000 , 1.58000000 TBPT,, 800000.000 , 1.64000000 TBPT,, 900000.000 , 1.66000000 TBPT,, 1000000.00 , 1.67000000 !* MPTEMP,,,,,,,, MPTEMP,1,0 MPDATA,MURX,3,,1 ! Valve coil MPTEMP,,,,,,,, MPTEMP,1,0 MPDATA,MURX,4,,1! Bobbin !*********************** pi=3.1416 msize=12 !Basic No. of elements/line !Geometric definition H=0.05! Height R=0.03 ! Outer Radius w=0.010 ! Coil width t=0.017 ! Pole length th=0.0065 ! Housing thickness d=0.001 ! MRF duct gap Rw=R-th-d dc=0.00052 ! Wire Radius res=0.0172e-6! Wire Resistivity Ac=pi*dc**2/4 rrc=res/Ac Nturn=w*(H-2*t)/Ac! No of turns Rc=rrc*Nturn*pi*2*(Rw-0.5*w) ! Wire Resistance I=2.5 ! Applied current J=I*4/dc/dc/pi! Current density PP=I**2*Rc! Consumption Power ! geometric model RECTNG,0,R,0,H, RECTNG,Rw,R-Th,0,H, RECTNG,Rw-W,Rw,t,H-t, RECTNG,0,Rw,0.0,t, RECTNG,0,Rw,H-t,H, RECTNG,Rw,R,t,H-t, !* FLST,2,6,5,ORDE,2 FITEM,2,1 FITEM,2,-6 AOVLAP,P51X NUMCMP,LINE NUMCMP,AREA ! Material assignment ! Housing FLST,5,3,5,ORDE,3 FITEM,5,5 FITEM,5,9 FITEM,5,-10 CM,_Y,AREA ASEL, , , ,P51X CM,_Y1,AREA CMSEL,S,_Y !* CMSEL,S,_Y1 AATT, 1, , 1, 0, CMSEL,S,_Y CMDELE,_Y CMDELE,_Y1 ! Core FLST,5,3,5,ORDE,2 FITEM,5,6 FITEM,5,-8 CM,_Y,AREA ASEL, , , ,P51X CM,_Y1,AREA CMSEL,S,_Y CMSEL,S,_Y1 AATT, 1, , 1, 0, CMSEL,S,_Y CMDELE,_Y CMDELE,_Y1 !* MR Fluid FLST,5,3,5,ORDE,2 FITEM,5,2 FITEM,5,-4 CM,_Y,AREA ASEL, , , ,P51X | CM,_Y1,AREA CMSEL,S,_Y CMSEL,S,_Y1 AATT, 3, , 1, 0, CMSEL,S,_Y CMDELE,_Y CMDELE,_Y1 !* Coil CM,_Y,AREA ASEL, , , , 1 CM,_Y1,AREA CMSEL,S,_Y CMSEL,S,_Y1 AATT, 4, , 1, 0, CMSEL,S,_Y CMDELE,_Y CMDELE,_Y1 !Mesh size per definition FLST,5,19,4,ORDE,9 FITEM,5,3 FITEM,5,-9 FITEM,5,11 FITEM,5,-12 FITEM,5,14 FITEM,5,-17 FITEM,5,21 FITEM,5,23 FITEM,5,-27 CM,_Y,LINE LSEL, , , ,P51X CM,_Y1,LINE CMSEL,,_Y LESIZE,_Y1,, , msize*1.5, , , , ,1 !* FLST,5,8,4,ORDE,5 FITEM,5,8 FITEM,5,12 FITEM,5,21 FITEM,5,23 FITEM,5,-27 CM,_Y,LINE LSEL, , , ,P51X CM,_Y1,LINE CMSEL,,_Y LESIZE,_Y1, , ,msize*2, , , , ,1 !* FLST,5,8,4,ORDE,7 FITEM,5,1 FITEM,5,-2 FITEM,5,10 FITEM,5,13 FITEM,5,18 FITEM,5,-20 FITEM,5,22 CM,_Y,LINE LSEL, , , ,P51X CM,_Y1,LINE CMSEL,,_Y LESIZE,_Y1, , ,msize, , , , ,1 ! Meshing MSHAPE,0,2D MSHKEY,0 !* AMESH,all !* FINISH ! Solving magnetic circuit /SOL ! Boundary condition FLST,2,12,4,ORDE,6 FITEM,2,1 FITEM,2,-2 FITEM,2,7 FITEM,2,17 FITEM,2,20 FITEM,2,-27 DL,P51X, ,ASYM ! Apply current density to the coil area FLST,2,1,5,ORDE,1 FITEM,2,1 BFA,P51X,JS, , ,J,0 ! Solving NCNV,0,0,0,0,0, SOLVE FINISH /POST1 ! Post processing SET,LAST ! Choose the last set of solution ! Define path PATH,p1,2,30,20, PPATH,1,0,R-th-d/2,0,0,0, PPATH,2,0,R-th-d/2,t,0,0, ! Calculate the magnetic intensity along the path PDEF,H1,H,sum,AVG /PBC,PATH, ,0 PCALC,INTG,H1in,H1,S,1, *GET,H1in,PATH, ,last,H1IN Hmr=1e-3*abs(H1IN)/t !PADEL,P1! Delete path ! Calculation of parameter neta=0.092 Q=0.0003 c=2. 5 C0=0.3 C1=0.42 C2=-0.00116 C3=1.0513e-6 ty=(C0+C1*Hmr+C2*Hmr**2+C3*Hmr**3) ! yield st. R1=(R-Th-d/2) del_P1=(6*neta*H*Q/(3.14*d**3*R1))*0.00001 del_P2=delta_P+2*C*t*ty*0.01/d del_P=del_P1+del_P2! Pressure drop OBJ=del_P1/del_P2! Objective |
ANSYS APDL program
Figure 13 shows the optimal solution of a single-coil annular MR valve constrained in the specific volume when a current of 2.5
Optimal solution of single-coil MR valves considering the valve ratio and pressure drop
Figure 14 shows the optimal solution of the two-coil annular MR valve. Initial values of
Optimal solution of two-coil MR valves considering the valve ratio and pressure drop
Figure 15 shows the optimization solution of the annular-radial MR valve. Initial values of
Optimal solution of annular-radial MR valves considering the valve ratio and pressure drop
Table 3 summarizes the optimization results for MR valve design abovementioned. The results show that the geometry of MR valve has a great effect on the valve performance. By choosing an optimal geometry, the valve performance such as pressure drop can be much improved and the power consumption can be significantly reduced. Among the MR valves constrained in the same volume, the two-coil annular MR valve provides the best value of valve ratio while the annular-radial can provide the best pressure drop at the optimal design parameters. For MR valves with three coils or more, it was shown that the performance of these valves is not better than that of the two-coil MR valve at optimal design parameters.
It was also shown by Nguyen et al. [79] that the optimal solution is affected by the applied current. The higher value of the applied current is the better performance of the valve is. However, when the applied current increases to a certain value the optimal solutions tends to be saturation. Therefore, it is advised that the applied current should be set by it maximum allowable value in the optimization problem of the MR valve.
Valve Type | Design Parameter [mm] | Valve Ratio, Pressure Drop & Power Consumption | ||
Initial | Optimal | Initial | Optimal | |
Single-coil annular valve | t = 17 wc= 10 th = 6.5 | t = 17.23 wc = 1.78 th = 7.43 | ||
Two-coil annular valve | a=10 t = 5 wc= 10 th = 4 | a=19.7 t = 10.6 wc = 6.38 th = 5.33 | N0=83.2W | |
Three-coil annular valve | b = 6 a =7 t = 7 wc= 10 th = 6 | b = 6.36 a =10.94 t = 5.84 wc=7.48 th = 3.35 | N0=55W | |
Annular-radial valve | t = 10 wc= 6 th = 8 | t = 8.6 wc= 3.1 th = 6.36 | N0=44.3W |
Optimization results for MR valve design
In this chapter, the methodology of optimal design of MRF-based devices was introduced. The chapter was started by a review of fundamentals and the theory behind MRF in section 2. In section 3, the operating modes used in MRF based devices were considered and several different devices featuring MRF are discussed. In the fourth section, optimal design methodology of MRF-based mechanisms was considered. In this section, firstly the necessity of optimal design and the state of the art were discussed. The magnetic circuit analysis and the modeling of MRF devices were then considered. In addition, the optimization problem of MRF devices was figured out and the methods to solve the problem were investigated. Section 5 dealt with a case study of MR valve optimal design. In this case study, several valve configurations such as single-coil MR valve, multiple-coil MR valve and annular-radial MR valve were considered. The optimization problem is to minimize the valve ratio by which maximized the control range and pressure drop of the MR valves. The results have shown the significance and the effectiveness of the proposed optimization methodology. Base on this study case, the optimal design of other MRF-based devices such as MR dampers, MR brakes can be performed.
Attention-deficit and hyperactivity disorders (ADHD) is a childhood-onset neuropsychiatric disorder affecting 5–6% of children [1]. The follow-up studies of children with ADHD showed that symptoms are evident even in adulthood in approximately two-third of patients [2] and that disorder is present in 2.5% of adults [1, 3]. The twin studies suggest a high heritability of ADHD, estimated to be at approximately 70% [4]. This is comparable to the heredity of other neuropsychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia (SCZ) [5]. Genetic studies shown a complex genetic etiology comprising both common variants such are single nucleotide polymorphisms (SNPs) [6], as well as rare variants causing a loss-of-function in single gene in form of single nucleotide variants (SNVs) [7], and deletions or duplications of multiple genes in form of copy number variations (CNVs) [8, 9, 10]. A SNP-based genome wide heritability studies can explain the genetic origin of the ADHD in approximately 22% cases, which still does not explain the large proportion of heredity set out in twin studies [6]. To some extent the difference can be explained by rare variants in form of SNVs and CNVs [11].
In 2010, a chromosomal microarrays (CMA) which are used for detection of genomic CNVs, became first-tier clinical diagnostic test for individuals with developmental delay and/or intellectual disability (DD/ID), ASD, and/or multiple congenital anomalies. Namely, a review of 33 studies including 21,698 patients tested by CMA showed that a pathogenic CNV could be determined in an average of 12.2% patients across all studies [12]. Since then, rare CNVs have been described across different neurodevelopmental disorders (NDDs) [13]. In individuals with ADHD a 1.33 times higher overall rate of CNVs larger than 100 kb compared to the healthy controls was observed [14].
Therefore, an important role of CNVs in etiology of ADHD is further discussed in this chapter.
CNVs are genomic structural variations causing the deletion or duplication of coding and non-coding segments of DNA. They vary in size, spanning from single gene to encompassing multiple genes. They can be common or rare events in genome acting as a disease cause.
CNVs occur in genome due to the segmental duplications present in certain regions in human genome. These repetitive sequences represent CNV “hotspots” as they make these regions prone to mutational mechanism called non-allelic homologs recombination. The process occurs during sperm or egg formation, therefore CNV prevalence remains relatively constant regardless of the severity of genomic disorder [15].
The CMA technology was designed to detect deletions and duplications across human genome randomly, without the need of specific suspected diagnosis of genomic disorder made by clinician. The technology enables us to identify the recurrent as well as novel disease associated CNVs [15]. Rare CNVs have been described as microdeletions or microduplications involved in many NDDs [12, 16, 17, 18, 19, 20].
Rare CNVs are considered to be present in less than <0.1% of general population. Disease associated CNVs are rare but collectively explain approximately 20% of DD/ID, 10% of ASD, and 5% of SCZ cases. However for other neuropsychiatric conditions the role of rare CNVs in disease pathophysiology is less clear, therefore diagnostics yield for CMA remains to be determined [17].
An important role in prevalence of rare CNV has its relative overall penetrance. CNVs with high overall penetrance are expected to be absent from general population whereas low penetrance CNVs have higher chance to be found in general population, where CNV carriers may have mild clinical manifestation [21, 22].
Different NDDs also share same CNVs effecting the same genes [4, 17] indicating on their clinical pleiotropy [13].
ADHD has a complex genetic architecture. The larger sample size and advances in technology enabled to study an effect of different classes of genetic variations in disease development. This revealed that ADHD is polygenic disorder like other neuropsychiatric disorders and its genetic architecture involves both the thousands of common variants with individually small effect size (SNPs), as well as rare variants causing a loss-of-function in single gene (SNVs) or small or larger genome deletions or duplications (CNVs) [23]. From all the genetic variants that contribute to etiology of ADHD, CNVs probably have the most evident clinical evidence, since they are enriched in several neuropsychiatric disorders [15].
ADHD is often associated with syndromic disorders [5]. For example, ADHD symptoms are present in more than 60% of patients with Williams-Beuren syndrome caused by microdeletion of chromosome region 7q11.23 [24] and approximately 40% patients with 22q11 deletion syndrome, also known as DiGeorge syndrome [25].
A parent-offspring trio studies showed a higher rate of de novo CNVs in children with NDDs. The highest is observed in 10% of children with ID/DD [26]. For ASD patients a 3- to 5-fold higher rate is observed than in control [27]. Similar rate was observed in SCZ-trio studies [28]. Only recently, studies of ADHD patients have reached the number of patients, which would unable similar studies to be performed as in ASD and SCZ patients [5]. Most recent trio-based study of ADHD patients have shown that overall mutation rate of de novo CNVs was 4.6% and similar to the rate observed in children with ADS, but slightly higher than in SCZ study [29]. Their rate was also higher than from previously trio-based ADHD study, which was 1.7% [30]. From the 14 de novo CNVs found in 13 ADHD probands, four CNVs: duplications of 15q13.1, 16p13.11 and 22q11.21 and deletion of 16p12.1, have been previously implicated in neuropsychiatric disorders or NDDs, once again highlighting their clinical pleiotropy [29].
In the study of Gudmundsson et al., a presence of 19 rare neuropsychiatric CNVs, that confer risk of ASD and SCZ, have been tested in 8883 ADHD probands. Presence was confirmed in 2.15% of individuals, compared to the 0.86% of controls. Only one CNV carrier had comorbid diagnosis of ADHD and ASD, and none for SCZ. Eight of the tested CNVs were significantly associated with ADHD risk: deletion of 2p16.3 (
There is still no ADHD-specific CNV identified. Although, there are still some incocistency about frequency of rare CNVs in ADHD patients [30, 34, 35, 36, 37, 38], studies of CNVs in ADHD patients show a higher burden of this structural variants compared to the control [8, 9, 30, 39, 40].
The CNVs found in patients with ADHD often coincide with ASD and SCZ chromosomal loci [41, 42, 43], which is also evident in clinical comorbidity of ADHD with this two disorders [44]. Stronger comorbidity is set for ASD [45] by common CNV-affected genes [8, 9, 30] and biological pathways [46]. Overlap of the disease-associated genes between ASD and ADHD was also observed in SNVs studies [7].
A large genome-wide CNV analysis was performed recently in 2691 patients diagnosed with different NDDs, in order to determine the pleiotropy of CNVs. For example, genes like
Interestingly, not much has been done in studying the CNVs implicated in ID/DD, since ADHD patients who have comorbid ID/DD are usually exclude from such studies [23].
A recent study of CNV involved genes obtained from 11 published studies was performed with aim to define ADHD-associated candidate genes. Among 2241 localized genes from 1532 CNVs, 26 genes were established to have highest credibility as ADHD candidate genes. This genes also share common biological topic such as transcription, mitochondrial biology, mRNA metabolism, and cytoskeleton [47].
By researching of the genome and CNV mapping, it was estimated that sequence included in CNVs contribute to the 4.8–9.5% of the genome. Additionally, it was postulated that about 100 genes can be deleted by CNVs and have no apparent phenotype [19]. Furthermore, an average mutation rate in individuals in the general population should be take into account, consequently rare variants could be false positive [48].
Therefore, the meaning of a rare unknown CNV identified in ADHD patient should be carefully interpreted.
Reaching the genetic diagnosis in ADHD patient can have many advantages for the patient as well as clinician. Molecular diagnosis can benefit in patients’ care in management and treatment (e.g. preference or avoidance of particular medications) as well as prognosis [15].
Genetic counseling is also important. The family based and twin studies of ADHD patients revealed a strong familial and genetic overlap of ADHD with ASD and ID. The individuals with monozygotic twin with ASD have an increased risk for ADHD compared to the risk observed in dizygotic twin studies. The association is higher for higher-functioning than lower-functioning ASD [23]. Siblings of ADHD probands have ninefold higher risk to ADHD compared to the siblings in controls [49]. ADHD is also strongly associated with lower IQ and ID indicating that they share heritability [23]. Additionally, family members of ADHD individuals are at elevated risk for neurodevelopmental and neuropsychiatric disorders. Knowing the genetic cause may have an impact on their management and treatment [23].
CNVs will lead to understanding how genes affect biological pathways involved in ADHD. For example, CNVs in glutameric genes were liked to cognitive and clinical impairments of ADHD [4]. In study of Thapar et al. found CNVs in ADHD patients were enriched in genes for which it was previously known to be involved in SCZ, Fragile X ID, and partly with autism [50]. More recently 26 ADHD-associated candidate genes were identified that share common biological topic such as transcription, mitochondrial biology, mRNA metabolism, and cytoskeleton [47].
Other features can be explain by CNVs. The duplications of
Moreover, knowledge of the cause of the disease assist in better understanding and felicitate the acceptance of the condition, improves genetic counseling and also refine possible future new treatments [15].
Although there are still no clear guidelines when to perform genetic testing for rare variants in ADHD patients, testing for CNVs is recommended in individuals with comorbid mild ID or ASD [23].
Technologies such as whole genome sequencing (WGS) that enable us to detect SNVs as well as structural variants in the genome in a single experiment, will facilitate the detection of even smaller CNVs, which we could not detect with CMA due to technology limitations.
Pathogenicity of rare large CNVs in NDDs and neuropsychiatric disorders is mostly defined, whereas a significance of a small nonrecurrent CNVs (<500 kb) is still ambiguous. In the study of 4417 patients referred to CMA testing 383 (8.67%) patient had at least one small, nonrecurrent CNV. Of these, 142 (3.21%) patients were carriers of pathogenic or likely pathogenic CNV, from which in 80 patients a single gene or exonic deletion of the gene was found [54].
A CNV study in adult ADHD patients did not found enrichment for large CNVs, however they did found significant increase of small CNVs [14]. Therefore, the relevance of new technologies in studying of genomic disorders will facilitate new genotype–phenotype correlation [15].
CNVs provide new opportunities for studying and management of psychiatric disorders including ADHD.
Detection of small CNVs of few kilo base in size is still difficult due to method limitations, although WGS of the ADHD patients promises their discovery. On the other hand, for the detection of large rare CNVs that occurs with frequency less than 1%, large sample size are needed [5].
Furthermore, parent-offspring trio studies of de novo CNVs and SNVs will contribute in disease etiology, since de novo aberrations in genome are more likely deleterious [28]. Identification of disease-associated genes and knowledge of their molecular functions will lead to better understanding of their disease pathology and hopefully enable better diagnostic and treatment [47].
Genetic counseling for polygenic disorders with complex genetic architecture as is ADHD is challenging, due to variable phenotypic outcomes and incomplete penetrance encountered in majority of genetic disorders. Therefore understanding the molecular etiology for clinicians is useful in patient management, in terms of improving risk predictions, screening for extra-psychiatric features, treatment, etc. [15]. New discoveries are also a starting point for identifying and assessing novel treatments in ADHD patients [23].
Though psychiatric genetics is unlikely to change the treatment of patients, it will eventually contribute to more personalized medicine [5]. Therefore the role of CNVs in clinical practice for ADHD patients remains to be seen.
My work was supported by the research program P4-0220 Comparative genomics and genomic biodiversity and research project Z3-9294 (B). Advanced genomic analyses of Slovenian children with Autistic Spectrum Disorders from the Slovenian Research Agency (ARRS).
No conflict of interest.
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