Summary of significant parameters in the development of the room and the AHU
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"9184",leadTitle:null,fullTitle:"Biorefinery Concepts, Energy and Products",title:"Biorefinery Concepts, Energy and Products",subtitle:null,reviewType:"peer-reviewed",abstract:"The interest in biofuel production and application is governed by the depletion of fossil fuel resources and the threatening pollution of the atmosphere because of the extensive emissions of greenhouse gases, which the present global vegetation cannot cope with. A remedy against the greenhouse gas emissions is the use of biomass presently grown as a source for biofuels. Biofuels can be further utilized as substrates for bulk chemical products. This approach is known as the biorefinery concept as an analogue to the oil-based refineries.The present book offers some examples and new ideas for the broader applications of biofuels and the resulting raw materials for energy and chemical products as alternatives to the traditional fossil fuels.",isbn:"978-1-78985-676-7",printIsbn:"978-1-78985-675-0",pdfIsbn:"978-1-83968-821-8",doi:"10.5772/intechopen.83180",price:119,priceEur:129,priceUsd:155,slug:"biorefinery-concepts-energy-and-products",numberOfPages:140,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"b97398a8e5c5fef9494e8ef39361a7dd",bookSignature:"Venko Beschkov",publishedDate:"October 7th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/9184.jpg",numberOfDownloads:4757,numberOfWosCitations:0,numberOfCrossrefCitations:8,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:17,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:25,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 12th 2019",dateEndSecondStepPublish:"April 29th 2019",dateEndThirdStepPublish:"June 28th 2019",dateEndFourthStepPublish:"September 16th 2019",dateEndFifthStepPublish:"November 15th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"191530",title:"Prof.",name:"Venko",middleName:null,surname:"Beschkov",slug:"venko-beschkov",fullName:"Venko Beschkov",profilePictureURL:"https://mts.intechopen.com/storage/users/191530/images/system/191530.jpg",biography:"Venko Beschkov was born in 1946 in Sofia, Bulgaria. He graduated in chemistry from the Sofia University, St. Clement Ohridski, Bulgaria (1969). He received his PhD in 1978 and his DSc degree in 1996. His present interests are chemical and biochemical processes for environment protection and utilization of renewable energy sources. He participated in 36 scientific projects, as well as in 20 applied projects.\nHe has published over 200 scientific papers, 2 monographs, and 7 chapters in selected issues (encyclopedia, books). Over 1500 citations of his papers have been noted. He was Head of the Institute of Chemical Engineering at the Bulgarian Academy of Sciences for 21 years (1993/2014) and Deputy-minister of Environment in the Bulgarian Government (1991/92).",institutionString:"Bulgarian Academy of Sciences",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Bulgarian Academy of Sciences",institutionURL:null,country:{name:"Bulgaria"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"885",title:"Bioenergy",slug:"sustainable-energy-bioenergy"}],chapters:[{id:"68068",title:"Biorefinery Safety: A Case Study Focused on Bioethanol Production",doi:"10.5772/intechopen.87990",slug:"biorefinery-safety-a-case-study-focused-on-bioethanol-production",totalDownloads:770,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"With reference to the framework for energy and climate, the European Union (EU) has stated that at least a 32% share of renewable energy consumption has to be achieved within 2030. This context generates attention to the potential hazards, which are associated with flammable biofuels, such as the bioethanol. One of the main hazards, referred to such biofuel, is the formation of potentially explosive atmospheres due to its evaporation from pools in case of accidental releases. In fact, in a bioethanol production plant (biorefinery), there are several components (flanges, valves, pumps, etc.), which can become potential emission sources in case of failure. Bioethanol is a high-boiling liquid, because its boiling temperature (Tboiling = 78°C) is higher than ambient temperature. Therefore, in case of release and spreading on a certain medium, evaporation occurs because of vapor diffusion. The chapter is focused on a case study. In particular, the chapter illustrates a comparison between two predictive models aimed at estimating the bioethanol evaporation rate, which is a fundamental parameter for determining the dilution degree and classifying the workplaces, where potentially explosive atmospheres could occur. The study investigates the influence of bioethanol release temperature and therefore of its vapor pressure on evaporation rate.",signatures:"Roberto Lauri and Biancamaria Pietrangeli",downloadPdfUrl:"/chapter/pdf-download/68068",previewPdfUrl:"/chapter/pdf-preview/68068",authors:[{id:"221280",title:"Dr.",name:"Biancamaria",surname:"Pietrangeli",slug:"biancamaria-pietrangeli",fullName:"Biancamaria Pietrangeli"},{id:"224518",title:"Dr.",name:"Roberto",surname:"Lauri",slug:"roberto-lauri",fullName:"Roberto Lauri"}],corrections:null},{id:"70804",title:"Biogas as a Source of Energy and Chemicals",doi:"10.5772/intechopen.90558",slug:"biogas-as-a-source-of-energy-and-chemicals",totalDownloads:923,totalCrossrefCites:4,totalDimensionsCites:8,hasAltmetrics:0,abstract:"The global economic development in the twentieth century has led to extensive use of fossils, such as oil, natural gas, and coal as fuels and chemical feedstocks. This extensive use of fossil fuels has led to enormous emissions of carbon dioxide as final product of combustion. The high absorption rate of infra-red rays by carbon dioxide has led to the so-called “greenhouse” effect. Nowadays, the renewable energy sources based on biomass have become very important with a trend to replace oil consumption at least partially and hence to remediate the emissions of greenhouse gases in atmosphere. Biofuels could be used as alternative raw material for chemical production. One of these biofuels is biogas released at anaerobic digestion of different natural organic waste. Another feature of biogas applications is its utilization as feedstock for the production of synthetic fuels and chemicals being now produced from oil and coal. A new approach is to use biogas as a fuel in fuel cells as a very promising option for energy production from renewable sources. The present review summarizes the applications of biogas for chemicals, starting with dry reforming and Fischer-Tropsch syntheses and as a source of energy, as heat and electricity production by co-generation and fuel cells.",signatures:"Sonia Damyanova and Venko Beschkov",downloadPdfUrl:"/chapter/pdf-download/70804",previewPdfUrl:"/chapter/pdf-preview/70804",authors:[null],corrections:null},{id:"68180",title:"Integrated Soybean Biorefinery",doi:"10.5772/intechopen.88111",slug:"integrated-soybean-biorefinery",totalDownloads:686,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The concept of biorefinery is analogous to that of petroleum refineries, but it uses renewable raw materials. However, the main objective of the biorefinery is to transform renewable agricultural materials into numerous and different commercially applicable products, allowing a viable economic competitiveness to traditional petrochemical refineries. In this chapter, we present a proposal for a biorefinery integrated from soybean as raw material, demonstrating its potential in this sector. In addition, special focus was given to the high value-added products present in the soybean oil deodorizer distillate (SODD), such as tocopherol, fatty acids, and squalene, which can be applied in the food, pharmacy, and cosmetic industries. In conclusion, the use of soybean raw material as a biomass in a biorefinery presents numerous environmental and economic advantages as high value-added products are formed. It is important to highlight that in this highly evolved integrated biorefinery model, the additional benefits of operational and administrative synergies will emerge over time.",signatures:"Fernando Luiz Pellegrini Pessoa, Hugo Villardi, Ewerton Emmanuel da Silva Calixto, Erika Durão Vieira, Ana Lucia Barbosa de Souza and Bruna Aparecida Souza Machado",downloadPdfUrl:"/chapter/pdf-download/68180",previewPdfUrl:"/chapter/pdf-preview/68180",authors:[null],corrections:null},{id:"68588",title:"Integrating Whole Cell Biotransformation of Aroma Compounds into a Novel Biorefinery Concept",doi:"10.5772/intechopen.88158",slug:"integrating-whole-cell-biotransformation-of-aroma-compounds-into-a-novel-biorefinery-concept",totalDownloads:806,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The synthesis of aroma compounds that are utilized as precursors of multiple synthesis chains in the pharmaceutical industries and as ingredients in food and fragrance industries can be carried out using chemical processes, enzyme biocatalysis and whole cell biotransformation. Whole cell biotransformation has the potential of being more environmentally benign than chemical synthesis and more cost-effective as compared to enzyme catalysis. In a recently published study by the authors, the aroma compound Ethyl(3)hydroxybutyrate was produced by whole cell biotransformation under aerobic and anaerobic conditions. The yield of the anaerobic processes was similar to that of the aerobic processes, but additionally generated CO2 and ethanol as useful by-products. In this chapter we illustrate how the production process of Ethyl(3)hydroxybutyrate by whole cell biotransformation can be integrated into a novel biorefinery concept, based on the finding that the production of Ethyl(3)hydroxybutyrate under anaerobic conditions is efficient and environmentally friendly. CO2 may be converted to bio-methane together with H2 produced from excess regenerative power. A life cycle assessment confirmed that the anaerobic whole cell biotransformation process embedded into a biorefinery concept including bio-methane production has a lower environmental impact as compared to a concept based on the aerobic whole cell biotransformation.",signatures:"Roland Hirschmann, Waldemar Reule, Thomas Oppenländer, Frank Baganz and Volker C. Hass",downloadPdfUrl:"/chapter/pdf-download/68588",previewPdfUrl:"/chapter/pdf-preview/68588",authors:[null],corrections:null},{id:"70885",title:"Lignin Hydrothermal Liquefaction into Bifunctional Chemicals: A Concise Review",doi:"10.5772/intechopen.90860",slug:"lignin-hydrothermal-liquefaction-into-bifunctional-chemicals-a-concise-review",totalDownloads:846,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Lignin, the second largest biomass after cellulose is underutilized. Yet, it remains the only natural source of aromatic, and phenolic compounds. It is imperative to, amidst the expanding interest on biomass conversion, to accord the necessary attention towards lignin degradation into value added chemicals. Specifically, its phenyl, guaiacyl, and syringyl derivatives. Understanding lignin degradation chemistry, goes a long way in its selective valorization into fuels and chemicals via thermochemical routes such as hydrothermal liquefaction (HTL). Therefore, development of technologies targeting value addition of products and by-products from lignin, would undoubtedly give way to emerging markets in the industry. Previous review papers focused on the general HTL of biomass, food waste, algae, and their model compounds. However, review on HTL of lignin is scarcely available. This paper presents the detailed literature analyses of the current trend in lignin degradation via HTL. Effect of HTL conditions including temperature, heating rate and catalyst has been reviewed. In-depth discussion on use of ionic liquids as catalyst for HTL of lignin has also been compiled. Other lignin degradation techniques such as pyrolysis and hydrolysis were also discussed. This is aimed at bringing together an up-to-date information on lignin degradation into selected chemical intermediates.",signatures:"Yahaya Alhassan, Ursel Hornung and Idris M. Bugaje",downloadPdfUrl:"/chapter/pdf-download/70885",previewPdfUrl:"/chapter/pdf-preview/70885",authors:[null],corrections:null},{id:"72722",title:"Biodiesel Production as a Renewable Resource for the Potential Displacement of the Petroleum Diesel",doi:"10.5772/intechopen.93013",slug:"biodiesel-production-as-a-renewable-resource-for-the-potential-displacement-of-the-petroleum-diesel",totalDownloads:726,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In the quest to comply with the Intergovernmental Panel on Climate Change (IPCC) on reducing the global temperature to 1.5–2.0°C as a measure to minimize the climate change caused by the emission of greenhouse gases from the combustion of fossil fuels, and the need for replacement of these fossil fuels, which are also generally believed to be depleting, biodiesel is being studied as a potential replacement for the conventional petroleum diesel. This fuel among other desired properties is renewable, biodegradable, sustainable, and emits less particles. It also contains no amount of sulfur, in addition to possessing most of the good characteristics of petroleum diesel. At the moment, more than 95% of biodiesel produced globally is obtained from vegetable oil feedstocks, which are usually very expensive and thus, without tax waiver and subsidy, makes biodiesel non-competitive with the petroleum diesel. Based on this, non-edible feedstocks are being investigated. Although, their oil yield is low, studies are carried out to ensure efficient extraction. The economics of the process is considered to determine the most economic variables that impact the profitability of biodiesel production. This chapter deals with the biodiesel classification, feedstocks, lipid/oil extraction, biodiesel production methods and the economic aspect of the process.",signatures:"Ifeanyichukwu Edeh",downloadPdfUrl:"/chapter/pdf-download/72722",previewPdfUrl:"/chapter/pdf-preview/72722",authors:[null],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6784",title:"Biofuels",subtitle:"State of Development",isOpenForSubmission:!1,hash:"9a31143f106bba91ce8430f49d3339af",slug:"biofuels-state-of-development",bookSignature:"Krzysztof Biernat",coverURL:"https://cdn.intechopen.com/books/images_new/6784.jpg",editedByType:"Edited by",editors:[{id:"155009",title:"Prof.",name:"Krzysztof",surname:"Biernat",slug:"krzysztof-biernat",fullName:"Krzysztof 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2019",bookSignature:"Muhammad Sarwar Khan and Kauser Abdulla Malik",coverURL:"https://cdn.intechopen.com/books/images_new/6976.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"212511",title:"Prof.",name:"Muhammad Sarwar",middleName:null,surname:"Khan",slug:"muhammad-sarwar-khan",fullName:"Muhammad Sarwar Khan"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"211046",title:"Dr.",name:"Ghulam",middleName:null,surname:"Mustafa",fullName:"Ghulam Mustafa",slug:"ghulam-mustafa",email:"drmustafa8@gmail.com",position:null,institution:{name:"University of Agriculture Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"212508",title:"Dr.",name:"Faiz",middleName:null,surname:"Ahmad",fullName:"Faiz Ahmad",slug:"faiz-ahmad",email:"faizahmad1980@gmail.com",position:null,institution:null},{id:"212511",title:"Prof.",name:"Muhammad Sarwar",middleName:null,surname:"Khan",fullName:"Muhammad Sarwar 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"19191",title:"Air-Conditioning PID Control System with Adjustable Reset to Offset Thermal Loads Upsets",doi:"10.5772/18818",slug:"air-conditioning-pid-control-system-with-adjustable-reset-to-offset-thermal-loads-upsets",body:'The heating, ventilating, and air-conditioning (HVAC) systems have huge different characteristics in control engineering from chemical and steel processes. One of the characteristics is that the equilibrium point (or the operating point) usually varies with disturbances such as outdoor temperature (or weather conditions) and thermal loads. The variations of the operating point intend to vary parameters of a plant model. Thus, the HVAC control systems are extremely difficult to obtain an exact mathematical model (Kasahara 2000). Proportional-plus-integral (PI) controllers have been by far the most common control strategy as the complexity of the control problem increased (Åström 1995).
Today, a variable air volume (VAV) system has been universally accepted as means of achieving energy efficient and comfortable building environment. While the VAV control strategies provide a high quality environment for building occupants, the VAV system analysis rarely receives the attention it deserves. As a result, basic control strategies for the VAV system have remained unchanged up to now (Hartman 2003).
In addition, applying the model predictive control method to the HVAC systems, the control performance has been highly improved by pursuing the deviation from the operating point (Taira 2004). According to this report, recognizing the deviation from the operating point and calculating the optimal control inputs about the newly obtained operating point on next sampling time, the control system gives better responses than the traditional feedback control system.
Motivated by these considerations in these reports, we consider the room temperature and humidity controls using the adjustable resets which compensate for thermal loads upsets. One of the primary objectives of the HVAC systems is to maintain the room air temperature and humidity at the setpoint values to a high quality environment for building occupants. The room temperature and humidity control systems may be represented in the same block-diagram form as single-variable, single-loop feedback control systems because this interaction is weak relative to the desired control performance.
In some applications, disturbances can be estimated in advance before they entered the plant. Particularly, in the HVAC systems, it is possible that the outdoor thermometer detects sudden weather changes and the occupant roughly anticipates thermal loads upsets. Using this information, disturbances can be offset by the compensation of the reset, which is the exactly same function as an integral (I) control action. In the previous paper, the compensation method of the reset for PID controllers was proposed and the control system for room air temperature was often effective in reducing thermal loads upsets (Yamakawa 2010).
In this paper, of special interest to us is how to tune PID parameters more effective for the room temperature and humidity control. And the control performances for compensation of the adjustable reset are compared with the traditional method of the fixed reset. Namely, obtaining the approximate operating point using outdoor temperature and thermal loads profiles and adjusting the reset, the stabilization of the control system will be improved. The validation simulations will be demonstrated in terms of three performance indices such as the integral values of the squared errors, total control input, and PID control input.
In this paper, we consider only the cooling mode of operation in summer and therefore refer to this system as a room air cooling system. The definition of variables in Equations is described in NOMENCLATURE.
To explore the application of PID controllers to the room temperature and humidity control system, we consider a single-zone cooling system, as shown in Figure 1. It is due to the fact that cooling and heating modes are found to perform nearly the same under most circumstances. The controlled room (the controlled plant) measures 10 m by 10 m by 2.7 m and is furnished with an air-handling unit (AHU) consisting of the cooling coil and the humidifier to control room air temperature and humidity. In general, since the responses of the AHU are faster than those of the controlled room, the dynamics of the AHU may be neglected for all practical purposes. Thus, as will be seen later, this rough assumption may be fairly validated. The model, however, possesses the important elements (the controlled room and the AHU) to analyze the air-conditioning system.
With this system, the room air temperature (
Overall structure of a single-zone cooling system.
Simplifying this thermal system to be a single-zone space enclosed by an envelope exposed to certain outdoor conditions is of significant interest to treat the fundamental issues in control system design (Zhang 1992, Matsuba 1998, Yamakawa 2009). This simplified thermal system (the room temperature model) can be obtained by applying the principle of energy balance,
where
The physical interpretation of Equation 1 is that the rate of change of energy in the room is equal to the difference between the energy supplied to and removed from the room. The first term on the right-hand side is the heat loss which is controlled by the supply air flowrate. The second term is the heat gain through the room envelope, including the warm air infiltration due to the indoor-outdoor temperature differential. The third term is the thermal loads from the internal heat generation and the infiltration. In this simplified model, any other uncontrolled inputs (e.g., ambient weather conditions, solar radiation and inter-zonal airflow, etc) are not considered.
It should be noted that all variables such as
These plant parameters have been obtained by experimental results (National Institute for Environment Studies in Tsukuba, Yamakawa 2009). The room dynamics can be approximated by a first-order lag plus deadtime system from the experimental data (Åström 1995, Ozawa 2003). Thus, the plant dynamics including the AHU and the sensor can be represented by,
Comparing to Equation 1, the plant gain (
Therefore,
where
To get some insight into the relations between Equation 1 and Equation 2, we will describe a bilinear system in detail (Yamakawa 2009). Introducing small variations about the operating points and normalizing the variables, Equation 1 has been transformed to a bilinear system with time delayed feedback. A parametric analysis of the stability region has been presented.
The important conclusion is that the stability analysis demonstrated the validity of PID controllers and there was no significant advantage in analyzing a bilinear system for VAV systems. It was fortunate that the linear system like a first-order lag plus a deadtime system derived in Equation 2 often satisfactorily approximated to the bilinear system derived in Equation 1. The linear system is an imaginary system, but it does represent it closely enough for some particular purpose involved in our analysis.
Certainly the linear model derived in Equation 2 can be used to tune the PID controller and the physical model derived in Equation 1 can be used for numerical simulations. Over the range upon which this control analysis is focused, the relations between Equation 1 and Equation 2 are determined to be sufficiently close.
The room humidity model can be derived by applying the principle of mass balance,
where
Equation 5 states that the rate of change of moisture in the room is equal to the difference between the moisture removed from and added to the room. The first term expresses a dehumidifying effect by the supply air flowrate. The second term is the moisture due to the occupants in the room. The absolute humidity
In the same way as the room temperature model, the humidity model can be approximated by a first-order lag plus deadtime system as shown in Equation 2. Thus, the plant dynamics concerned with the room humidity model can be represented by,
The gain constant
Thus,
where
Block diagram for AHU.
The room humidity can be determined by regulating the moisture of the supply air to the room. This implies that the room humidity can be indirectly controlled. Similarly the first-order lag plus a deadtime model by Equation 6 can be used to tune the PID controller and the physical model by Equation 5 can be used in numerical simulations. It does not mean that Equation 5 and 6 are mathematically equivalent.
Figure 2 shows the simple block diagram for the AHU that conditions supply air for the room. Air brought back to the AHU from the room is called return air. The portion of the return air discharged to the outdoor air is exhaust air, and a large part of the return air reused is recirculated air. Air brought in intentionally from the outdoor air is outdoor air. The outdoor air and the recirculated air are mixed to form mixed air, which is then conditioned and delivered to the room as supply air.
The AHU consists of a cooling coil, a humidifier, and a fan to control supply air temperature (
where
The humidifier is the most important actuator to control the room relative humidity (
where
Considering the steady-state of the dynamics of the humidifier, the supply air temperature
As can be seen in Equation 11, the supply air temperature (
The air flowrate from the outdoor air is considered 25% of the total supply air flowrate. This ratio will be held constant in this study. Note that the pressure losses and heat gains occurring in the duct have negligible effects on the physical properties of air for simplification. The absolute humidity of mixed air entering the cooling coil can be described by,
where
370.44 [kJ/K] | |
270 [m3] | |
1.3 [kJ/kg K] | |
1.006 [kg/m3] | |
9.69 [kJ/min K] | |
0.1932 [kJ/min K] | |
121.72 [kJ/min] | |
16.66 [m3/min] | |
0.00 [m3/min] | |
0.33 [m3/min] | |
0.00 [m3/min] | |
13.1 [C] |
Summary of significant parameters in the development of the room and the AHU
In this section, the conversion from the absolute humidity to the relative humidity is briefly explained. The relative humidity is derived from the air temperature and the absolute humidity of the air (ASHRAE 1989; Wexler and Hyland 1983).
First, the air temperature must be converted to the absolute temperature as,
where
Second, to evaluate the supply air temperature
where
Overall of the temperature-humidity control system.
Finally, the relative humidity
Figure 3 shows a block diagram of the room temperature and humidity control systems using adjustable resets which compensate for thermal loads upsets. In this figure, signals appear as lines and functional relations as blocks. The primary controlled plant is the room. The cooling coil, the humidifier and the damper are defined as the secondary controlled plants (to produce appropriate actuating signals). The following control loops are existed in our room temperature and humidity control system:
Room air temperature control system
Room air humidity control system
The control outputs of interests are room air temperature (
Taking the PID control algorithm into account, one of control inputs, related to the room air temperature (
where
where
Equation 17 can be given in a discrete-time system when control input and error signal are respectively assumed to be
This is called the position algorithm because
From Equation 1, the operating point at its steady-state can be written:
The reset (
In Equation 21, the supply air temperature (
the maximum (75%), the medium (50%), and the minimum (25%),
where 100 % means the maximum supply air flowrate 16.66 [m3/min].At any given point of operation, the reset (
To control the room air relative humidity, another one of control inputs that vary according to the control actions is the rate of moist air produced in the humidifier
where
where
Since the supply air temperature (
The reset
Second, substituting Equation 24 into Equation 9, 11 and 12, Equation 24 can be rewritten by,
However, as will be seen in Equation 25, the first term is small in comparison to the second term and
Table 2 provides PID parameters tuned by the traditional ultimate sensitivity method (Ziegler and Nichols 1942) and the empirical modified PID method.
The ultimate sensitivity method is simple and intuitive. It has been still widely used, either in its original form or in some modification. Since it only gives “ball-park” values, it is necessary to make manual tuning to obtain the desired performance. Our empirical modified PID controller can help improve the time response of a control system because thermal loads and operating conditions are changing continuously in HVAC systems.
In modified PID parameters for room air temperature control, the proportional gain (
To illustrate the control performance of the room temperature and humidity control systems, several simulation runs are made. Representative outdoor temperature and thermal loads profiles for one-day (between 08:00 in the morning and 08:00 in the next morning) are assumed as shown in Figure 4. These profiles are based on the experimental data obtained from the National Institute for Environmental Studies in Tsukuba, Japan. In the right hand side of Figure 4, the dashed line depicts the artificial estimated value of the thermal load. At the start-up (at 08:00 in the morning), the feedback control system takes over and controls the room air temperature and relative humidity. These simulation runs are carried out under the same conditions mentioned above. Figure 5 depicts the adjustable reset (
The following control configurations are used in our room temperature and humidity control. These abbreviations are common throughout the remainder of this paper.
(a) Temp. control | ||||
Conventional PID | 11.65 | 2.55 (4.57) | 13.26 (1.16) | |
Modified PID | 8.73 | 0.8 (10.9) | 10 (1.15) | |
(b) Humidity control | ||||
1.22 | 0.26 (4.65) | 1.41 (1.16) |
PID parameters. (
Outdoor temperature and thermal loads profiles.
Reset of supply air flowrate.
Number of control outputs of interest, Room temperature and humidity control. This refers to the room air temperature and relative humidity control.
Setpoints of control outputs
Regarding the room air temperature
Fixed setpoint, The setpoint
Variable setpoint, The setpoint
Regarding the room air relative humidity
The setpoint
Control strategies for the reset
Conventional PID control, This refers to conventional PID control with the fixed reset (
Modified PID control, This refers to modified PID control with the adjustable reset (Figure 5).
Performance indices, The control performance should be evaluated by defining three performance indices.
ISE (the integral of squared error), ISE =
ICI (the integral of control input), ICI =
IPID (the integral of control input produced in PID controller only), IPID =
Simulation results of conventional PID.
Room temperature and humidity control
Typical daily simulation results show that the conventional PID and the suitably modified PID controllers can maintain the room air temperature and relative humidity close their respective setpoints irrespective of variable thermal loads. The method of determining PID parameters for the modified controller is practical for room temperature and humidity control systems.
Figure 6 and 7 show the responses to the fixed setpoint of the room air temperature for the cases of the conventional PID and the modified PID controls, respectively.
In Figure 6, there are sudden changes in
When looking over results of Figures 6 and 7, it should be noted that the responses (
Simulation results of Modified PID.
Conventional PID | Modified PID | |
ISE | 3.09 | 7.95 |
ICI | 2.08104 | 2.08104 |
IPID | 8742 | 2734 |
Comparison of control performance indices to fixed setpoint.
Because the reset for the modified PID control can be adjusted very often, it becomes difficult to maintain
Variable setpoint profile.
Table 3 shows that the results of the validation simulations in terms of three performance indices. For the ISE (tracking accuracy), it is evident that the sharply change of the reset aggravates the tracking accuracy of
As a matter of fact, the merit of the modified PID control becomes obvious when the maximum capacity of the controller is limited.
Figure 8 depicts the setpoint profile ((
It can be seen from Figure 10 that suitably tuned modified controller can maintain the room air temperature and humidity close to their respective setpoints suppressing such huntings. The effectiveness of the modified PID control can be confirmed. By comparing these responses with those of Figure 6 and 7, it is clear that the humidifier is turned on very often and the hunting of the room air temperature may occur simultaneously.
Fig. 9 and 10 demonstrate locally rapid oscillation of the humidifier when the indoor relative humidity
Simulation results of conventional PID.
Conventional PID | Modified PID | |
ISE | 5.98 | 8.83 |
ICI | 1.92104 | 1.92104 |
IPID | 4276 | 3005 |
Comparison of control performance indices to variable setpoint.
Table 4 represents the control performance indices obtained by typical daily simulation results. A comparison with Table 3 shows that there is very little difference in performance between the fixed setpoint and the variable setpoint. For the ISE, the ISE for the modified PID is larger than that for the conventional PID. This means that the I action is effective for not only elimination of offset (steady-state error) but also disturbance attenuation. Tracking accuracy and disturbance attenuation will be enhanced by selecting high integral gain.
For the ICI, it is striking that the ICI values are exactly the same for two control strategies. For the IPID, the modified PID control gives slightly better results than the conventional PID control. It is concluded that the modified PID control should be also incorporated by limiting the maximum control input available to the controller.
Simulation results of Modified PID.
In this paper, the room temperature and humidity control systems with the conventioanl PID control using fixed reset or the modified PID control using adjustable resets which compensate for thermal loads upset are examined. The simulation results for one-day operation based on practical outdoor temperature and thermal loads profiles provide satisfactory control characteristics. The results of validation simulations are demonstrated in terms of three performance indicies (as three integrals of squared error (ISE), control input (ICI), and control input in PID controller only (IPID)).
The results obtained in this study are summarized in the following:
The room air temperature and humidity illustrate instabilities locally due to humidifier working.
By changing the setpoint of the room air temperature on the basis of the outdoor temperatures profile, the control performance can be remarkably improved.
In daily operation, when the reset is adjusted at every hour, the sharply change of the reset aggravate the response of the room air temperature. The response can be improved by proper selection of the computational period.
The proposed control strategy for the adjustable reset cannot be effective for energy-savings, but has a possibility in case that there exists a limitation of the maximum control input available to the controller.
Finally, the results given in this paper were motivated by the desire to obtain satisfactory performance with adjustable reset better than that with fixed reset. Consequently, it is concluded that there is little inherent advantages in designing the modified PID controller with adjustable reset. However, since this modified PID control lightens the total amount of control input produced in the controller, it can be good candidates for the next HVAC controllers.
The work reported here is being continued to validate several conclusions obtained by experimental results.
h= rate of moist air produced in humidifier (kg/min)
qL= thermal load from internal heat generation (kJ/min)
qB= fan load (59.43 kJ/min)
qd= load by humidifier ( (190.1 – 1.805θc)h kJ/min)
p= evaporation rate of a occupant (0.00133 kg/min)
P= total pressure of mixed air (101.3 kPa)
pw= partial pressure of water vapor at the inlet of air-handling unit (kPa)
pws= partial pressure of saturated vapor at temperature θc (kPa)
h0= reset of rate of moist air produced in humidifier (kg/min)
n= number of occupants in the room (-)
KP= plant gain of room temperature dynamics
TP= time constant of room temperature dynamics
LP= deadtime of room temperature dynamics
KPh= plant gain of room humidity dynamics
TPh= time constant of room humidity dynamics
LPh= deadtime of room humidity dynamics
This research was partially supported by the National Institute for Environment Studies in Tsukuba. The authors would like to acknowledge staffs of Controls Group for their contribution to this study.
Cyclodextrins (CDs) are natural compounds, obtained by the enzymatic modification of starch [1], that consist of at least six glucopyranose units linked by α-1,4 glycosidic bond. They have a truncated cone shape delimiting a relatively hydrophobic cavity and two polar rims bearing primary hydroxyl groups (the narrow rim) and secondary hydroxyl groups (the broader rim) [2]. The main feature of CDs is the formation of noncovalent complexes through host-guest interaction, which is, in fact, a summation of several noncovalent steps and overall represents an entropically driven process [3]. The host-guest interactions are determined by different factors, such as size, shape, charge, or polarity of the molecular actors involved [4]. This type of complexation has been extensively documented since the discovery of CDs, especially for low-molecular-weight compounds, by using a variety of physicochemical methods depending on the properties of the guest molecules [5, 6, 7]. These methods refer to nuclear magnetic resonance (NMR), UV-Vis, and fluorescence spectroscopies, as well as calorimetric methods. Although these molecules were reported at the end of the 19th century, the explosion of their applications started in the eighth decade of the 20th century [8]. CDs can be involved in the formation of noncovalent interactions with polymers, giving rise to special types of assemblies known as rotaxanes or pseudorotaxanes [9, 10].
The other feature of CDs is the presence of numerous primary and secondary hydroxyl groups that allow a facile derivatization in order to obtain new molecules that can be used as building blocks for large assemblies. Owing to the difference in reactivity of the primary and secondary groups, it is possible to control the functionalization, which ensures a selectivity of this process. The easiest way to synthesize monoderivatives is by obtaining monotosylated CD, especially for β-CD. This synthesis was studied in detail. A few syntheses are available in order to obtain pure CDs monotosylated at the primary hydroxyl rim that can be used further as bricks for preparing other derivatives. Monotosylated CD can be easily obtained in aqueous alkaline solution in good yields [11]. This derivative will be easily transformed further into amines [12] or thiols [13] that can be modified through maleimides or iodoacetamides [14]. There are also strategies describing the functionalization of primary and secondary rims that can allow obtaining of large supramolecular assemblies. It can be taken into account that the functionalization of the secondary rim is more difficult than the modification of the primary rim, as the hydroxyls that mark the larger rim require a strong base to become activated. In the review of Liu
In this review, we will focus on the two main features of CDs: to generate large supramolecular assemblies through host-guest interactions and to use functionalization in order to improve the properties of polymeric systems by the incorporation of host CD units. The polymeric systems taken into discussion refer to polyrotaxanes and pseudorotaxanes, the particular cases of sliding gels, the pluronic gels, and the functionalization of various synthetic and natural polymers with CD units. An important part will be focused on noncovalent and covalent hydrogels containing CD units.
Rotaxanes are supramolecular structures consisting of at least one ring threaded through an axial molecule, with the particularity that the dissociation of this assembly is hindered by bulky groups at the ends of the axial molecule [17]. CDs may play the role of a ring that is lined up on a polymer chain. The general procedures for the synthesis of polyrotaxanes involve two pathways: the threading followed by rotaxination and the slippage of CD over a bulky group (Figure 1). These methods are used for the preparation of CD-based pseudorotaxanes and rotaxanes in aqueous media [18]. The formation of pseudorotaxanes is dependent on the relation between the sizes of the CD cavity and polymeric chain. Thus, α-CD will generate polyrotaxanes and pseudopolyrotaxanes with polyethylene glycols and polyamines [19, 20], while β-CD with polypropylene glycols [21] and γ-CD with polyvinyl alcohol [22], which often leads to gel systems. The endcapping of polyethylene glycols with bulky substituents, such as bis(3,5-dinitrobenzoyl) and bis(2,4-dinitrobenzoyl), will favor the formation of polyrotaxanes with γ-CD [23].
Schematic representation of CDs and pseudopolyrotaxanes.
Many water-soluble polymers act as nonionic surfactants by self-association in micelles that are sensitive to temperature and the presence of other molecules. CDs can form inclusion complexes with nonionic surfactants from the Triton X or pluronic classes. In the case of Triton X, α-CD can complex the polyethylene chain, while β-CD complexes the nonpolar head (the iso-octylphenyl and phenyl groups) [24]. CDs can also modify the critical micelle concentration or are able to disrupt the micelles due to the complexation of polymers or surfactants [25]. As an example, the Triton X-100 nonionic surfactant, consisting of a short chain of polyethylene glycol and an aromatic nonpolar head, is able to form micelles at concentrations higher than 2.2 mM [26]. CDs can form inclusion complexes with this molecule with different geometries and stoichiometries depending on the CD size. Using isothermal titration calorimetry (ITC) measurements, it was possible to evaluate the binding constants for β-CD and γ-CD by assuming a stoichiometry of 1:1 and 1:2 for β-CD and of 1:1 for γ-CD, both involving the complexation of the nonpolar surfactant head. Conversely, in the case of α-CD, the complexation was supposed to be through the formation of pseudorotaxane by the inclusion of the polyethylene chain, assuming 1:5 stoichiometry, although the ITC data were not conclusive [27]. The interaction of β-CD with Triton X-114 led to the formation of larger aggregates involving hydrogen bonds with β-CD. This has been studied as a function of β-CD concentration and temperature, and it was observed that, at higher β-CD concentration, a transition from micelle to vesicle occurred. This effect is different from the more common effect of CDs on surfactant aggregation [28].
The effects of various CDs on the micellization and gelation of pluronics have also been reported. For such systems, changes in micellar concentration, in gelation, as well as changes of the hydration layer around the polymer chains during phase transition, when CDs are placed among polymeric chains, can be the result of pseudorotaxane formation [29, 30, 31, 32, 33]. Being water soluble, CDs will be more probable to target the region of the micelles placed at the water interface. Two studies involving EPR and fluorescence spectroscopies along with rheological and tube inversion methods explore the effect of 2-hydroxypropyl-β-CD on the micelle-to-gel phase transition of pluronic F127 [34, 35]. It was revealed that the spectral parameters of molecular probes (commercially available spin probes, spin-labeled CDs, CDs labeled with fluorophores, or dual molecular probes) deviate from the linear dependence with temperature (Figure 2), thus indicating that the macroscopically observed phase transformation is related to changes at the nanoscale level. The results also led to the conclusion that the presence of CDs at the used concentrations does not induce micellar rupture but determines an increase in the micellar water content, which suggests an increase of the micellar size and excludes the formation of pseudopolyrotaxanes.
Representation of the micelle-to-gel transition in F127/HPB systems (A), variation of hyperfine splitting constant with temperature (B) and variation of EPR spectra of spin probe with temperature (C) in F127 system [
Rotaxanes and pseudorotaxanes generate networks that lead to the formation of hydrogels. A particular case refers to the formation of supramolecular networks named sliding gels that are characterized by mobile or sliding crossing points. A classical sliding network results from the intermolecular crosslinking of α-CD/polyethylene glycol pseudorotaxanes (Figure 3) [36, 37, 38]. The crossing points are, thus, mobile, and this will determine a mobility of the overall network. These gels are formed by linking CD units that belong to different chains.
Schematic representation of the supramolecular network of a sliding gel.
The properties of these sliding gels can be described by topological parameters such as the complexation degree (number of CD units on a polymer chain), the crosslinker fraction (defined as the ratio of the mole number of crosslinker on the mole number of CDs), and the interactions between the swelling solvent and the constitutive parts of the network [39]. In many cases, the sliding motion depends on the swelling solvent, as well as on other factors such as the pH. For instance, in the case of pseudorotaxanes formed between a triblock copolymer consisting of polyethylene amine/polyethylene glycol/polyethylene amine, and α-CD, with crossing points obtained in the presence of 1,10-carbonyldiimidazole, the gel properties are dependent on the pH value [40].
This section aims to summarize new research that has emerged in the past few years on materials composed of synthetic or natural polymers to which CD derivatives have been chemically attached. The polymers discussed here were chosen considering the extensive investigations and applications in pharmaceutics and biomedicine as drug excipients, biocompatible alternative materials in tissue engineering, contrast enhancers, molecular recognition models, etc. To achieve novel and/or enhanced properties of these classes of compounds, the functionalization with different CD units is employed. To covalently attach CDs onto polymer chains, multiple types of crosslinking agents (citric acid, epichlorohydrin, aldehydes, carbodiimides, and amines) can be used. In recent years, polymers functionalized with CD units have been studied for the development of a variety of polymeric networks [41, 42]. Moreover, the polymeric material based on CD units can be modulated in such a way to form nano/micro/macroparticles, gels, micelles, coating films, or fibers [43, 44, 45]. Many studies in this regard are performed using chitosan, mostly due to its remarkable biological properties, including antimicrobial activity, nontoxicity, biocompatibility, and biodegradability, and at the same time to the possibility to functionalize it [46, 47].
For instance, Campos
Not only natural polymers were grafted with CD derivatives, but also synthetic ones. In this regard, the polyacrylic acid was modified by attaching a CD derivative (2-aminoethyl)amino-deoxy-β-CD) [54]. The study targeted to obtain the self-assembly of β-CD and adamantyl moieties covalently linked to polyacrylate networks for application in controlled complexation and release of ethyl orange, methyl orange, and methyl red. Another study developed a multistimulus responsive supramolecular hydrogel based on host-guest and electrostatic interactions between β-CD dimer and methoxy-azobenzene molecules grafted on polyacrylic acid [55]. The obtained materials showed thermo-, photo-, and pH-responsive behavior determining a reversible sol-gel transition.
Chabalala
Polymers containing CDs have the ability to form supramolecular hydrogels mostly due to host-guest complexation or by the inclusion of linear polymeric chains into host cavities [58]. The latter leads to the formation of pseudorotaxanes. Literature data show that, unlike β-CD, α and γ-CD are able to generate interactions favorable to the obtaining pseudorotaxanes [59]. However, in particular cases, pseudorotaxanes were prepared using β-CD and polylactic acid or polypropylene glycol [60, 61].
Several studies regarding host-guest interactions in hydrogel systems are reported in the literature [60, 62, 63]. By appending host and guest units to the polymer chains, one can modify and control their behavior in solutions and obtain gel systems. This strategy ensures conditions for the creation of topological crosslinks based on host-guest interactions, which have the advantage of being reversible and movable. Host and guest units can be grafted on the chains of numerous polymers (hyaluronic acid [64, 65], carboxymethyl cellulose [66, 67], sodium alginate [42, 68], polyacrylic acid [55, 69, 70], polyvinyl alcohol [71, 72], polymethyl vinyl ether-alt-maleic acid [73, 74], poly-N-isopropylacrylamide [75], and polyethylene glycol [76]). These supramolecular gels find use in the medical field for drug delivery, tissue culture, and medical treatments [77, 78]. Depending on the desired application, hydrogels formed by host-guest interactions can be generated in several ways. Therefore, CD having the role of guest molecules can be grafted separately on polymer chains and mixed with polymers bearing guest grafts to form supramolecular assemblies [41, 60].
The formation of alginate gels in the presence of divalent cations was monitored by EPR spectroscopy considering the changes in the dynamics of spin-labeled alginate chain [79]. In a recent study, we showed that the functionalization of alginate with CD (as host) or adamantane (as guest) influences the properties of ionotropic generated gel in the presence of Ca2+ ions [42]. As a consequence, polymer functionalization and subsequent interactions between the appended host and guest units change the morphology of the resulting xerogels (Figure 4).
Schematic representation of ionotropic gelation of functionalized alginates. SEM images of alginate xerogels: (a) nonfunctionalized alginate and (b) alginate functionalized with CD and adamantane units [
In fact, the derivatization, together with the host-guest interactions, has an impact on the rheological properties, i.e., the hydrogels made from a mixture of adamantane-functionalized and CD-functionalized alginates presented higher storage and elastic moduli values (Figure 5a). Appending the paramagnetic moieties to these functionalized alginates allows evidencing the changes at the molecular level of the dynamic of the overall motion (Figure 5b). All these findings led to the conclusion that the presence of host-guest interactions can modulate the features of alginate hydrogels.
(a) Viscoelastic properties and (b) EPR spectra of alginate hydrogels functionalized with β-CD or adamantane units [
The polymerization of the inclusion complex is another technique that can be used to obtain CD-based hydrogels. Ikura
In aqueous media, host-capped polymers can be mixed with guest-grafted chains to obtain hydrogels. Ioniță
Another method to obtain hydrogels is the mixing of end-capped guest crosslinkers with certain host-grafted polymers [41, 60]. A recent study has shown that the multivalence effect within a polyethylene glycol-adamantane/β-CD-alginate system can be quantified to create hydrogel-like cell matrices [82]. The complexation of CD functionalized alginate with adamantyl end groups on polyethylene glycol chains changed the valence of the system. Thus, a correlation could be observed between the multivalence generated by the variation in the number of polyethylene glycol arms and the strength of binding affinities inside the hydrogel.
A particular type of gel is formed between guest-grafted polymers that are capable of forming multilayer vesicles and small host molecules grafted on different polymeric chains. A good example is the gel formed by thiolated monolith polymers, in which β-CD vesicles were introduced in order to formulate a hydrogel with pH-responsive properties [83].
Polymeric gel formation can be described using rheological, viscosity, and dynamic light scattering measurements. These methods provide global information on such systems. Spectroscopic methods, such as fluorescence, IR, or UV-Vis spectroscopy, are often used to describe changes in the organization of macromolecules that are usually governed by noncovalent interactions [84]. In the particular case of gel formation, electron microscopy techniques are used to evidence the gel fibers. An interesting, powerful, but still rarely used approach in studying gels involves EPR spectroscopy [34, 79, 81, 84, 85]. The EPR spectroscopy is suitable to study polymer systems and gels as the method can provide insights into local, static, and dynamic properties of these systems. This method can evidence nanoscale inhomogeneities in polymers systems [86, 87].
By using spin-labeled CDs, it was possible to monitor the gel formation process, while the diffusion of various spin probes can evidence the nonuniform properties of covalent gels [81, 88, 89]. Other EPR studies explored the self-assembly of pluronic F127 leading to gel phase as a function of temperature and concentration of CD [34, 35] or the formation of supramolecular gels resulted by the assembly of low-molecular-weight gelators [85].
Over the past four years, data from the literature indicate some comprehensive reviews of CD-based polymer applications [63, 90, 91, 92, 93]. The most common applications of these materials are in the field of drug delivery [60, 94, 95], biomedical engineering [90, 96, 97], food industry [93, 98, 99], responsive adhesives [100, 101], coatings [102, 103], sensors [104, 105], and environmental remediation [106, 107].
Table 1 exemplifies some of the most recent applications reported in the literature on polymers functionalized with CD units.
Material | Applications | Ref. |
---|---|---|
β-CD-chitosan nanoparticles | Carrier for carvacrol and linalool | [48] |
β-CD-chitosan/graphene oxide hydrogel | Removal of methylene blue | [49] |
β-CD-chitosan/alginate complex | Encapsulation and release of piroxicam | [50] |
β-CD-alginate hydrogels | Paclitaxel drug release | [51] |
β-CD-alginate gel beads | Release of methyl orange | [52] |
β-CD-alginate | Matrix for | [53] |
β-CD-polyacrylonitrile nanofiber | Adsorption of bromophenol blue and atrazine from aqueous systems | [56] |
β-CD polymer-tetrafluoroterephthalonitrile | Removal of malachite green | [108] |
β-CD polymer-tetrafluoroterephthalonitrile | Agent for monitoring endocrine disrupting chemicals from water | [109] |
β-CD based polymeric adsorbent | Pollutants removal (rhodamine B, Congo red and cadmium ions) from wastewater | [110] |
2-hydroxypropyl-β-CD-polyacrylic acid | Removal of ibuprofen | [111] |
β-CD-activated charcoal-Na alginate magnetic beads | Removal of methyl violet, brilliant green, norfloxacin, ciprofloxacin and copper ions from aqueous systems | [112] |
β-CD-carboxymethyl chitosan | Sensor for direct determination of manganese | [113] |
β-CD-alginate-graphene oxide hydrogel | Injectable hydrogel for soft tissue engineering | [114] |
β-CD-epichlorohydrin-carboxymethyl chitosan | Bioactive enhancement of cyanidin-3-glucoside | [115] |
β-CD-polyurethane/chitosan | Gentamicin sulphate drug release | [116] |
β-CD-Fe3O4-chitosan nanoparticles | Support for lipase immobilization | [117] |
β-CD-chitosan beads | Support for keratinase immobilization | [118] |
Applications of polymers functionalized with β-cyclodextrin.
The general lines of polymer functionalization with cyclodextrins and resulting changes of their properties have been reviewed in this chapter. These can be applied for generating and studying other polymer-cyclodextrin systems. The EPR spectroscopy can be used as a method for proving changes at nanoscale level in such systems due to host-guest interactions occurring in polymer systems. The EPR data can be linked with other experimental data provided by classical methods used to characterize polymers in solution and in gel states, like rheology, electron microscopy techniques, etc.
The chapter was supported by the Romanian National Authority for Scientific Research, CNCS-UEFISCDI, project code PN-III-P1-1.1-PD-2021-0169 and contract number PD 106 and Romanian Academy within the research programs “
The authors declare no conflict of interest.
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We describe the marker-less technologies in the area of AR, indoor marker-less AR, outdoor marker-less AR, real-time solutions to the tracking problem, real-time registration, cultural heritage in AR, 3D remonstration techniques, as well as presenting the problems in each research.",book:{id:"7699",slug:"advanced-methods-and-new-materials-for-cultural-heritage-preservation",title:"Advanced Methods and New Materials for Cultural Heritage Preservation",fullTitle:"Advanced Methods and New Materials for Cultural Heritage Preservation"},signatures:"Hoshang Kolivand, Abdennour El Rhalibi, Mostafa Tajdini, Sarmad Abdulazeez\nand Pisit Praiwattana",authors:[{id:"151219",title:"Prof.",name:"Abdennour",middleName:null,surname:"El Rhalibi",slug:"abdennour-el-rhalibi",fullName:"Abdennour El Rhalibi"},{id:"225824",title:"Dr.",name:"Hoshang",middleName:null,surname:"Kolivand",slug:"hoshang-kolivand",fullName:"Hoshang Kolivand"},{id:"256916",title:"Dr.",name:"Sarmad",middleName:null,surname:"Abdulazeez",slug:"sarmad-abdulazeez",fullName:"Sarmad Abdulazeez"},{id:"256917",title:"Dr.",name:"Pisit",middleName:null,surname:"Praiwattana",slug:"pisit-praiwattana",fullName:"Pisit Praiwattana"},{id:"289071",title:"Dr.",name:"Mostafa",middleName:null,surname:"Tajdini",slug:"mostafa-tajdini",fullName:"Mostafa Tajdini"}]},{id:"36570",doi:"10.5772/45619",title:"Archaeological Geophysics - From Basics to New Perspectives",slug:"archaeological-geophysics-from-basics-to-new-perspectives",totalDownloads:6627,totalCrossrefCites:4,totalDimensionsCites:8,abstract:null,book:{id:"1999",slug:"archaeology-new-approaches-in-theory-and-techniques",title:"Archaeology",fullTitle:"Archaeology, New Approaches in Theory and Techniques"},signatures:"Roger Sala, Ekhine Garcia and Robert Tamba",authors:[{id:"131865",title:"Dr.",name:"Roger",middleName:null,surname:"Sala",slug:"roger-sala",fullName:"Roger Sala"}]},{id:"36574",doi:"10.5772/37679",title:"The Study of Shell Object Manufacturing Techniques from the Perspective of Experimental Archaeology and Work Traces",slug:"the-study-of-shell-object-manufacturing-techniques-from-the-perspective-of-experimental-archaeology-",totalDownloads:3127,totalCrossrefCites:1,totalDimensionsCites:6,abstract:null,book:{id:"1999",slug:"archaeology-new-approaches-in-theory-and-techniques",title:"Archaeology",fullTitle:"Archaeology, New Approaches in Theory and Techniques"},signatures:"Adrián Velázquez-Castro",authors:[{id:"113840",title:"Dr.",name:"Adrian",middleName:null,surname:"Velazquez",slug:"adrian-velazquez",fullName:"Adrian Velazquez"}]},{id:"70612",doi:"10.5772/intechopen.89154",title:"The Technological Diversity of Lithic Industries in Eastern South America during the Late Pleistocene-Holocene Transition",slug:"the-technological-diversity-of-lithic-industries-in-eastern-south-america-during-the-late-pleistocen",totalDownloads:690,totalCrossrefCites:1,totalDimensionsCites:4,abstract:"Brazilian archaeological literature has insisted for decades upon associating hunter-gatherer sites dated to the Pleistocene–Holocene transition either to the Itaparica tradition, if located in central or northeastern Brazil, or to the Umbu tradition and Humaitá tradition, if located in southern Brazil, Uruguay, or any other adjacent part of Paraguay and Argentina. These associations have been based almost entirely on the presence or absence of lesmas and “projectile points,” regardless of their morphological and technological features. In the Uruguayan archaeological literature, three other cultures are recognised: Fell industry, Catalanense industry, and Tigre tradition, all in the Uruguayan region. However, the last 10 years of systematic studies on the lithic assemblages from these sites have shown that Paleoindian societies from Eastern South America are more culturally diverse than expected and that previously defined archaeological cultures present several issues in their definition, suggesting that many of these “traditions” are not valid and should no longer be used. Instead, new lithic industries and archaeological cultures should be defined only when cultural patterns are observable through systematic analyses.",book:{id:"9251",slug:"pleistocene-archaeology-migration-technology-and-adaptation",title:"Pleistocene Archaeology",fullTitle:"Pleistocene Archaeology - Migration, Technology, and Adaptation"},signatures:"João Carlos Moreno De Sousa",authors:[{id:"303361",title:"Dr.",name:"João Carlos",middleName:null,surname:"Moreno De Sousa",slug:"joao-carlos-moreno-de-sousa",fullName:"João Carlos Moreno De Sousa"}]}],mostDownloadedChaptersLast30Days:[{id:"36570",title:"Archaeological Geophysics - From Basics to New Perspectives",slug:"archaeological-geophysics-from-basics-to-new-perspectives",totalDownloads:6628,totalCrossrefCites:4,totalDimensionsCites:8,abstract:null,book:{id:"1999",slug:"archaeology-new-approaches-in-theory-and-techniques",title:"Archaeology",fullTitle:"Archaeology, New Approaches in Theory and Techniques"},signatures:"Roger Sala, Ekhine Garcia and Robert Tamba",authors:[{id:"131865",title:"Dr.",name:"Roger",middleName:null,surname:"Sala",slug:"roger-sala",fullName:"Roger Sala"}]},{id:"36576",title:"Homage to Marcel Proust - Aspects of Dissemination and Didactic in a Museum and a Science Centre: Science Communication Visions for the Third Generation Museums",slug:"generations-of-ancient-history-dissemination-towards-the-public-at-the-university-museum-in-trondhei",totalDownloads:2669,totalCrossrefCites:1,totalDimensionsCites:1,abstract:null,book:{id:"1999",slug:"archaeology-new-approaches-in-theory-and-techniques",title:"Archaeology",fullTitle:"Archaeology, New Approaches in Theory and Techniques"},signatures:"Kistian Overskaug",authors:[{id:"117119",title:"Dr.",name:"Kristian",middleName:null,surname:"Overskaug",slug:"kristian-overskaug",fullName:"Kristian Overskaug"}]},{id:"63772",title:"Cultural Heritage in Marker-Less Augmented Reality: A Survey",slug:"cultural-heritage-in-marker-less-augmented-reality-a-survey",totalDownloads:1644,totalCrossrefCites:6,totalDimensionsCites:9,abstract:"Augmented reality (AR) is considered as one of the most significant technologies in the field of computer graphics and is utilised in many applications. In this chapter, we have presented a brief comprehensive survey of cultural heritage using augmented reality systems. This survey describes the main objectives and characteristics of marker-less augmented reality systems through presenting up-to-date research results in this area. We describe the marker-less technologies in the area of AR, indoor marker-less AR, outdoor marker-less AR, real-time solutions to the tracking problem, real-time registration, cultural heritage in AR, 3D remonstration techniques, as well as presenting the problems in each research.",book:{id:"7699",slug:"advanced-methods-and-new-materials-for-cultural-heritage-preservation",title:"Advanced Methods and New Materials for Cultural Heritage Preservation",fullTitle:"Advanced Methods and New Materials for Cultural Heritage Preservation"},signatures:"Hoshang Kolivand, Abdennour El Rhalibi, Mostafa Tajdini, Sarmad Abdulazeez\nand Pisit Praiwattana",authors:[{id:"151219",title:"Prof.",name:"Abdennour",middleName:null,surname:"El Rhalibi",slug:"abdennour-el-rhalibi",fullName:"Abdennour El Rhalibi"},{id:"225824",title:"Dr.",name:"Hoshang",middleName:null,surname:"Kolivand",slug:"hoshang-kolivand",fullName:"Hoshang Kolivand"},{id:"256916",title:"Dr.",name:"Sarmad",middleName:null,surname:"Abdulazeez",slug:"sarmad-abdulazeez",fullName:"Sarmad Abdulazeez"},{id:"256917",title:"Dr.",name:"Pisit",middleName:null,surname:"Praiwattana",slug:"pisit-praiwattana",fullName:"Pisit Praiwattana"},{id:"289071",title:"Dr.",name:"Mostafa",middleName:null,surname:"Tajdini",slug:"mostafa-tajdini",fullName:"Mostafa Tajdini"}]},{id:"73769",title:"Human Evolution in the Center of the Old World: An Updated Review of the South Asian Paleolithic",slug:"human-evolution-in-the-center-of-the-old-world-an-updated-review-of-the-south-asian-paleolithic",totalDownloads:883,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"The Indian Subcontinent was an important geographic region for faunal and hominin evolution in Asia. While the Oldowan as the earliest technocomplex continues to be elusive, the oldest Acheulean is dated to ~1.5 Ma and the early Middle Paleolithic is ~385 ka (from the same site). New Late Pleistocene dates have been reported for the Middle Paleolithic which continues up to 38 Ka in southern India. The Upper Paleolithic remains ambiguous and requires critically multidisciplinary investigations. The microlithic evidence appears to spread rapidly across the subcontinent soon after its emergence at ~48 Ka (though its origin is debated) and continues into the Iron Age. The timeline of the initial arrival of Homo sapiens continues to be debated based on the archaeology (advanced Middle Paleolithic vs. microlithic) and genetic studies on indigenous groups. Other issues that need consideration are: interactions between archaics and arriving moderns, the marginal occurrence of symbolic behavior, the absolute dating of rock art and the potential role of hominins in specific animal extinctions and ecological marginalization. The region does not appear to have been a corridor for dispersals towards Southeast Asia (although gene flow may have occurred). Instead, once various prehistoric technologies appeared in the Subcontinent, they possibly followed complex trajectories within relative isolation.",book:{id:"9251",slug:"pleistocene-archaeology-migration-technology-and-adaptation",title:"Pleistocene Archaeology",fullTitle:"Pleistocene Archaeology - Migration, Technology, and Adaptation"},signatures:"Parth R. Chauhan",authors:[{id:"307040",title:"Dr.",name:"Parth",middleName:null,surname:"Chauhan",slug:"parth-chauhan",fullName:"Parth Chauhan"}]},{id:"73386",title:"Island Migration, Resource Use, and Lithic Technology by Anatomically Modern Humans in Wallacea",slug:"island-migration-resource-use-and-lithic-technology-by-anatomically-modern-humans-in-wallacea",totalDownloads:742,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Island migration and adaptation including both marine and terrestrial resource use and technological development by anatomically modern humans (AMH) are among the most significant issues for Pleistocene archaeology in Southeast Asia and Oceania, and directly related to the behavioral and technological advancements by AMH. This paper discusses such cases in the Wallacean islands, located between the past Sundaland and the Sahul continent during the Pleistocene. The Pleistocene open sea gaps between the Wallacean islands and both landmasses are very likely the major factor for the relative scarcity of animal species originating from Asia and Oceania and the high diversity of endemic species in Wallacea. They were also a barrier for hominin migration into the Wallacean islands and Sahul continent. We summarize three recent excavation results on the Talaud Islands, Sulawesi Island and Mindoro Island in Wallacea region and discuss the evidence and timeline for migrations of early modern humans into the Wallacean islands and their adaptation to island environments during the Pleistocene.",book:{id:"9251",slug:"pleistocene-archaeology-migration-technology-and-adaptation",title:"Pleistocene Archaeology",fullTitle:"Pleistocene Archaeology - Migration, Technology, and Adaptation"},signatures:"Rintaro Ono, Alfred Pawlik and Riczar Fuentes",authors:[{id:"177123",title:"Dr.",name:"Rintaro",middleName:null,surname:"Ono",slug:"rintaro-ono",fullName:"Rintaro Ono"},{id:"300616",title:"Dr.",name:"Alfred",middleName:null,surname:"Pawlik",slug:"alfred-pawlik",fullName:"Alfred Pawlik"},{id:"330591",title:"Dr.",name:"Riczar",middleName:null,surname:"Fuentes",slug:"riczar-fuentes",fullName:"Riczar Fuentes"}]}],onlineFirstChaptersFilter:{topicId:"263",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"7",title:"Bioinformatics and Medical Informatics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",isOpenForSubmission:!0,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},{id:"8",title:"Bioinspired Technology and Biomechanics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",isOpenForSubmission:!0,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",isOpenForSubmission:!0,editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",biography:"Dr. Luis Villarreal is a research professor from the Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana, Baja California, México. Dr. Villarreal is the editor in chief and founder of the Revista de Ciencias Tecnológicas (RECIT) (https://recit.uabc.mx/) and is a member of several editorial and reviewer boards for numerous international journals. He has published more than thirty international papers and reviewed more than ninety-two manuscripts. His research interests include biomaterials, nanomaterials, bioengineering, biosensors, drug delivery systems, and tissue engineering.",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:23,paginationItems:[{id:"82392",title:"Nanomaterials as Novel Biomarkers for Cancer Nanotheranostics: State of the Art",doi:"10.5772/intechopen.105700",signatures:"Hao Yu, Zhihai Han, Cunrong Chen and Leisheng Zhang",slug:"nanomaterials-as-novel-biomarkers-for-cancer-nanotheranostics-state-of-the-art",totalDownloads:21,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11405.jpg",subseries:{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering"}}},{id:"82184",title:"Biological Sensing Using Infrared SPR Devices Based on ZnO",doi:"10.5772/intechopen.104562",signatures:"Hiroaki Matsui",slug:"biological-sensing-using-infrared-spr-devices-based-on-zno",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hiroaki",surname:"Matsui"}],book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"82122",title:"Recent Advances in Biosensing in Tissue Engineering and Regenerative Medicine",doi:"10.5772/intechopen.104922",signatures:"Alma T. 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He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. 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Animals need to receive a properly balanced diet. One of the new challenges we are now faced with is sustainable animal diets (STAND) that involve the 3 P’s (People, Planet, and Profitability). We must develop animal feed that does not compete with human food, use antibiotics, and explore new growth promoters options, such as plant extracts or compounds that promote feed efficiency (e.g., monensin, oils, enzymes, probiotics). 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